KR20050014253A - Pharmaceutical composition containing Bando Deep Ocean Water or the concentrate thereof having scavenger effect of stress - Google Patents

Abstract

PURPOSE: A health supplementary beverage composition for reducing stress containing a concentrate of ground water is provided. The concentrate of ground water is obtained by concentrating ground water by itself or after the demineralization and non-toxic and can be used as a health supplementary beverage for reducing stress. CONSTITUTION: The health supplementary beverage composition contains 0.01 to 80% by weight of a concentrate of ground water, which is pumped out of the ground of 700 to 1,000m. The ground water is concentrated by itself or after the demineralization and contains inorganic components selected from Na, Ca, Mg, K, Zn and the like and metal ions selected from Fe, Mn, St and the like in large quantities. The composition has a daily dose level of 0.01 to 10g per body weight. The hair growing agent composition is a tablet, capsule, solution, dispersion or syrup.

Description

Pharmaceutical composition containing Bando Deep Ocean Water or the concentrates having scavenger effect of stress}

The present invention relates to a pharmaceutical composition for stress relief, containing a concentrate obtained as it is or concentrated in the deep peninsula deep water or desalted.

Stress, in short, refers to our body's response to changes in our surroundings that require adaptation, usually in the form of physical, mental, and emotional responses. This stress can be either positive or negative as part of your life. If stress can be used in a good way, it can be a motivating factor to get the most out of our capabilities. However, excessive stress that is difficult to handle or prolonged exposure to stress can be a factor in physical and mental illness.

In particular, modern people suffer from various stresses, and if excessive stress persists beyond the body's ability to adapt, it causes problems with the mental and body homeostasis, causing various physical and mental symptoms. For example, physical symptoms include fatigue, headache, insomnia, myalgia, heart palpitations, chest pain, abdominal pain, nausea, coldness of the hands and feet, hot flashes, and mental symptoms include concentration, memory loss, indecision, emptiness, Anxiety, nervousness, restlessness, congestion, anger blasts, and violent behavior. In addition, stress is associated with heart disease, cancer, lung disease, accidents, cirrhosis, suicide and other causes of death. Many of these known diseases are related to the production of free radicals in the human body by internal and external stresses and various causes. There are mainly free radical species (ROS) and free radical species (RNOS), which are associated with or are caused by various diseases in the human body.

As such, in recent years, it has been found that stress is the cause of all illnesses, and the need for stress relief is emphasized.

Accordingly, various methods for relieving and overcoming stress are also known. First, there are general mind care and health care related topics such as having a positive mind and attitude, learning and training how to relax, and exercising regularly. In this case, each person's determination and continuous efforts are required. In addition, when problems arise due to stress, counseling is usually provided by a psychiatrist or psychotherapist. This case only helps the patient himself to face and cope with his own internal problems.

Drinking tea in general can protect the body's immune capacity, which can be damaged by stress, and also has been shown to be effective against inflammation such as gastritis, gastric ulcer and duodenal ulcer.

In addition, it can help to relieve stress as a stress-relieving beverage using rose extract (Korea Patent Registration No. 10-02-89555-0000), a method of preparing a stress relief drink containing kelp and fucoidan (Korean Patent Registration No. 10-03 -56747-0000), functional stress relief drink using the chrysanthemum extract (Korean Patent Registration No. 10-02-78203-000), functional beverage composition (Korean Patent Registration No. 10-02-07605-0000) and the like.

However, studies on stress releasing agents still need more research.

In addition to sodium chloride, seawater contains a large amount of magnesium, calcium, potassium, silicon, and the like, and this is known to contain a balanced amount of trace elements, which are essential nutrients for the human body.

Seawater is called deep seawater, which is distinguished from surface water, and deep sea water refers to seawater 200 meters or less from the surface of seawater. It contains a lot of inorganic nutrients such as nitrogen, phosphorus, and silicic acid needed for plant growth because photosynthesis does not occur. In addition, since it is not polluted by air or chemicals, and is not polluted by solar or general bacteria, it has a small number of marine bacteria, so it has excellent physical cleanliness, and it contains a balance of essential trace elements and various minerals. , Potassium, sodium), zinc, selenium, manganese, etc., and also excellent immune function against various diseases caused by stress or constitution, and is known to be very clean than surface water or ground water used as drinking water. In the current state of serious marine pollution, surface water is not suitable for food and beverage, but since deep sea water does not contain much viable bacteria and contains no pathogenic organisms, it is extremely safe when selected as a beverage. (Japanese Patent Publication No. 7-34728).

The characteristics of deep ocean water are eutrophic (mineral) which is rich in nutrients decomposed by bacteria and contains a large amount of minerals such as calcium and magnesium because there is no phytoplankton consuming nutrients in the deep sea where sunlight does not reach. ), Less than 200 meters from the surface seawater, low concentration of organic matter, no contamination by E. coli or common bacteria, and less cleanliness, less likely to be polluted by chemicals from land or air, Its stability is low and its water temperature is low, and since deep sea water is water that has been formed for thousands of years, its properties are stable, and it is matured due to the action of various enzymes. Of the metal ions dissolved in the balance It is known that for having properties such as excellent scavenging effect on free radicals.

This deep sea water is obtained by heating and concentrating the seawater, cooling the concentrate, and then removing the crystals obtained from the concentrate, and continuing this until the volume of the concentrate is concentrated to less than 1/1000 of the original volume. The enhancer and its manufacturing method are described, and a healthy drink effective for the prevention of modern diseases such as diabetes, allergic disease, myocardial infarction, etc. is disclosed by adding a part of the solution to the beverage (Japanese Patent Publication No. 2580428).

In addition, an electrolyte such as sodium chloride is added to the deep sea water and subjected to electrolysis in an electrolysis device. The strongly acidic oxidized water obtained from the anode side (the redox potential is above 1000 mV at pH 2.4 to 2.7 or less) and the alkali reduced water obtained from the cathode side are known The use of strongly acidic oxidized water has been used for disinfection sterilization of medical instruments and sterilization of foods due to its oxidizing power and acidic sterilization. For alkaline reduced water, abnormal fermentation in the stomach, chronic diarrhea, indigestion, antacid and It is known to be effective against gastrointestinal diseases such as excessive stomach acid (see Japanese Patent Laid-Open No. 2001-198575).

In addition, focusing on the minerals contained in deep sea water, essential minerals such as metals and urea, such as copper and zinc, in addition to calcium and magnesium, which are known as minerals, have been identified. It has been known to develop vitamin nutrients in seawater with reduced sodium chloride content (Japanese Patent Laid-Open No. 60-255729), and since the number of viable bacteria is smaller than the surface water, this deep water is added to the beverage as natural mineral water. It has also been developed as a mineral beverage (Japanese Patent Laid-Open No. 5-219921).

In addition, beverages in which bitter juices and mines are obtained by taking seawater into fresh water dewatered using a reverse osmosis apparatus are known (Japanese Patent Laid-Open No. 10-150960). .

However, the above-mentioned manufacturing processes have a problem that mineral concentrates and minerals are rarely contained or water-free may be produced because they undergo an evaporative concentration step such as reverse osmosis or electrolysis. In addition, research has been conducted on mineral water beverages in which mineral components obtained from deep water obtained by desalting are added (Japanese Patent Laid-Open No. 2001-190256).

Such deep water is developed as a gel preparation for skin treatment such as atopic dermatitis (Japanese Patent Laid-Open Publication No. Hei 9-110702), or blended into food processed products such as tofu, and quasi-drug products (Japanese Patent Laid-Open Publication No. Hei 9-28269). Based on this deep seawater, it is developed as a health beverage by adding raw liquid juice, sugar raw materials, side materials, and drinking water (Japanese Patent Publication No. 5-219921), or during the manufacturing process used during the bread making process. A manufacturing method using deep water as a water or liquid to be used has been studied (Japanese Patent Laid-Open No. 2000-333592).

However, the deep sea water used in the above-mentioned prior art uses deep water collected from Fujiyama Bay, etc., near Japan.

In addition, domestic research using deep sea water is limited to the manufacturing method of food using deep sea water layer, the food and drinking water production method containing deep sea water, and the study on the composition showing the stress relief effect using deep sea water. Was not.

The deep sea water also has four major minerals (magnesium, calcium, potassium, sodium), zinc, selenium, manganese, etc., and also has excellent immunity against various diseases caused by stress or constitution. It is known that this balance is included and has properties such as an excellent scavenging effect on active oxygen by the action of dissolved metal ions. In addition, calcium is generally known to help relieve stress by stabilizing nerves.

Free radicals are chemicals that kill, dissolve, and sterilize fungi, viruses, and foreign substances when they enter the body. However, when this free radical is excessively increased in the body, it has a double side attacking the tissues of the body. Therefore, there is an antioxidant wall (antioxidative defense mechanism) in our body to remove harmful free radicals produced in the body. In other words, enzymes such as SOD (superoxide dismutase) and various antioxidants exist in the human body to protect the body from attack of free radicals. More specifically, in the cell, free radicals are removed by glutathione peroxidase, made of selenium and glutathione, and superoxide dismutase and catalase enzymes called SODs that require zinc, copper, and manganese. Normally, 2-5% of the oxygen we breathe is converted into free radicals. The problem is the excess of free radicals produced to exceed the antioxidant wall in the body. This can be caused by: 1) stress 2) ultraviolet radiation 3) radiation 4) chemicals (pesticides, pesticides, medicines, nitrogen compounds) 5) intense exercise (hard physical labor), overeating, drinking and smoking 6) pollution. In the environment of excessive stress in modern times, the balance between the generation and removal of free radicals in the living body is broken, so it is very important to relieve stress or to disperse the minerals necessary for the production of antioxidants or antioxidants from the outside. On the other hand, it is also important to eat ingredients such as calcium to stabilize the nerves to help relieve stress. Therefore, this study investigated the effects of stress relief and defense by using the deep peninsula, which is a marine deep water that can be collected from Korea's waters, and found that various components, especially the four major minerals (magnesium, calcium, potassium, sodium), zinc, The present invention was completed by checking the effects of stress relief of selenium, manganese and the like.

It is an object of the present invention to provide a pharmaceutical composition having a stress relieving effect containing a concentrate obtained as it is or concentrated as a deep sea water of the peninsula deep water or desalted water.

In order to achieve the above object, the present invention provides a pharmaceutical composition for stress relief containing a concentrate obtained as it is or concentrated in the deep water of the peninsula itself or desalted.

The above peninsula deep water means deep sea water taken from 700 to 1000 m underground near the west coast including Gyeonggi-do, Korea, which has anti-cancer activity such as selenium (Se) and zinc as well as sodium, calcium, magnesium and potassium. It is characterized by containing a large amount of inorganic ions and metal ions such as iron, manganese and stronium.

In another aspect, the present invention provides a manufacturing process for treating the deep water for the use of the mineral component contained in the deep water of the peninsula deep water, such as antimicrobial agents or fungicides, specifically, the extracted deep water of the peninsula is cationic or anionic ion exchange resin Sodium chloride crystals produced from the concentrate obtained by desalting treatment, evaporating deep water into natural drying, or removing some moisture through natural drying and concentrating the remaining concentrated deep water through heating, Evaporation concentration process to separate, or electrolysis method to decompose sodium chloride component through two-stage electrolysis device, drying process such as natural drying, hot air drying, freeze drying, etc. Desalted and dried deep water powder can be prepared.

Cation exchange resins or anion exchange resins may be used for the desalination fixation through the ion exchange resin, and preferred cationic exchange resins are AG 50W-x8, Amberlite IR-120, Doex 50W-x8. Strongly acidic cation exchange resins such as these; Weakly acidic cation exchange resins such as Amberlite IRC-50, Bio-Rex 70, Duoolite-436 and the like; Weakly basic cation exchange resins such as Amberlite IRA-67, Doex 3-x4A, and the like; Strongly basic cation exchange resins such as AG 2x8, Amberlite IRA-400, Doex 2-x8 series and the like; Or exchange resins composed of improved fibrous celluloses such as cation exchange resins such as CM-cellulose, SE-cellulose, and anion exchange resins such as DEAE cellulose; Or made of crosslinked dextran, eg, G-25 and G-50 beaded cation Sephadex-type resins, eg agarose, eg Sepharose CL and Biogel A Sepharose-type resins Or improved bead type ion exchange resins such as Fractogels or Toyopearl resins are preferred, and more preferred exchange resins are preferably Toyopearl DEAE type exchange resins, which are weakly basic anion exchange resins, and even more preferred. The exchange resin is TOYOpearl DEAE-650C type exchange resin.

In addition, the electrolysis device used in the desalination method using the electrolysis method is not limited to this, as long as it is used to electrolyze water. It is preferable to decompose during the period, and to continuously feed water through tap water. As the electrolytic apparatus, a cathode is a ferrite electrode, a platinum-plated titanium electrode, a titanium platinum sintered electrode, and the like. A cathode is a stainless steel electrode, a platinum-plated titanium electrode, a titanium platinum sintered electrode, or the like. The electrolysis device of is preferable.

The concentrate of the peninsula deep water after the above process contains abundant mineral components. Therefore, the concentrate of the peninsula deep water of the present invention has the characteristics of excellent scavenging effect on stress against active oxygen, stress relief and defense effect by the action of dissolved metal ions.

The present invention provides a stress relief pharmaceutical composition containing a peninsula deep water as an active ingredient.

The deep peninsula of the present invention can be used as it is or the desalted water as it is, or a concentrate obtained by concentrating itself or desalted water can be used, and the concentrate can be used in the form of a concentrate or dried to form a powder. Can be used. Preferably, a concentrated powder is used to dry the concentrate of the deep peninsula water obtained by desalting and concentrating.

The pharmaceutical composition for the stress relief effect has a weight ratio of 0.01 to 80%, preferably 1 to 50% by weight of the concentrated peninsula itself or desalted as it is or concentrated relative to the total weight of the composition. To provide a composition.

A pharmaceutical composition having a stress releasing effect of the present invention may further include suitable carriers, excipients and diluents which are commonly used in the manufacture of pharmaceutical compositions.

Carriers, excipients and diluents that may be included in the pharmaceutical composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium Silicates, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

Formulation of the pharmaceutical composition having a stress relief effect of the present invention is a warning agent, granules, lotions, liniments, limonades (limonades), fragrances, powders, syrups, eye ointments, solutions, extracts, Elixiers, ointments, lactose, liquid extracts, emulsions, suspensions, eye drops, tablets, suppositories, injections, spirits, acupuncture, premises, pasta, cataplasma, capsules Agents, troches, tinctures, or pills are preferred, but are not limited to the above formulations, and may be used in the form of oral dosage forms, external preparations, suppositories, and sterile injectable solutions.

In addition, the composition having a stress releasing effect of the present invention may include other components that can be used in the stress releasing agent within a range that does not impair the effects of the composition having a stress releasing effect of the present invention.

The pharmaceutical composition of the present invention may be administered parenterally or orally according to the desired method, and the amount of 0.01 to 10 g, preferably 1 to 5 g per 1 kg of body weight as an active ingredient per day is divided into 1 to several times. You can drink it. The drinking dose level for a particular person may vary depending on the person's weight, age, sex, health condition, diet, drinking method, excretion rate, and severity of symptoms, the drinking dose limiting the scope of the invention in any aspect. It is not.

In addition, the present invention uses a semi-depth layer water itself or desalted water showing a stress relief effect as it is, or contains a concentrate obtained by concentrating itself or desalted water, and includes a food supplement which is food acceptable. Provide dietary supplements.

The composition of the present invention may be added to food or beverages for the purpose of stress relief. At this time, the amount of the composition in the food or beverage, in general, the health food composition of the present invention can be added to 0.01 to 15% by weight of the total food weight, the health beverage composition is 0.02 to 10 g, preferably based on 100 ml Preferably at a ratio of 0.3 to 1 g.

The health beverage composition of the present invention has no particular limitation on the liquid component except for containing the composition as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, like ordinary drinks. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of said natural carbohydrates is generally about 1-20 g, preferably about 5-12 g per 100 ml of the composition of the present invention.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof. , Organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. The compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected from the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

Hereinafter, the present invention will be described in detail by Examples and Experimental Examples.

However, the following Examples and Experimental Examples are only illustrative of the present invention, and the content of the present invention is not limited to the following Examples and Experimental Examples.

Example 1 Desalination of Deep Peninsula Water

20 kg of deep peninsula water taken from 800 m underground area near Gyeonggi-do, Korea was added to each of the positive and negative cathode supply tanks of the two tanks, and the direct current of 0.1 to 3.0 A was allowed to flow for 60 minutes. After completion, 8 kg of a desalted peninsula deep water solution was obtained on the cathode side.

Example 2 Preparation Example 1 of Peninsula Deep Water Concentrate Powder

20 kg of deep peninsula water taken from 800 m underground area near Gyeonggi-do, Korea was added to each of the positive and negative cathode supply tanks of the two tanks, and the direct current of 0.1 to 3.0 A was allowed to flow for 60 minutes. After the completion, the solution obtained on the negative electrode side was collected and heated at 80 to 120 ° C. for 24 hours, and the resulting concentrate was left to dry at room temperature for 2 days to obtain 200 mg of mineral powder.

Example 3 Preparation Example 2 of Peninsula Deep Water Concentrate Powder

20 kg of deep peninsula water taken from 800 m underground area of Gyeonggi-do, Korea was continuously added to 160 ml of Toyo pearl ^R (Tosoh, Japan) DEAE-650C ion exchange resin, equilibrated with demineralized distilled water. In addition, the eluate obtained by eluting at a rate of 2 ml / hour by a stepwise elution method in which 500 ml of 0 M, 0.1 M, 0.2 M, 0.3 M, and 3 M sodium chloride solution was flowed was added to the dialysis membrane (average flat thickness). Dialysis was repeated three times with demineralized distilled water for 4 hours with 32 mm, 100 ml / ft benzoylated dialysis tubing, Sigma, USA), followed by freeze drying with a lyophilizer (three-way cold-heated SFDSM24L, Korea) to 150 mg of mineral. A powder was obtained.

Example 4 Characterization of Deep Peninsula Water and Its Component Analysis

The peninsula deep water of Example 1 and the conventional deep sea water of Japan (see Japanese Patent Laid-Open No. 2002-4598) had a difference in characteristics as shown in Table 1, and thus the mineral powder obtained in Example 1 As a result of testing the component analysis according to the method described in APHA (1998 revised edition) at the Korea Chemical Testing Institute, the component analysis results shown in Table 2 were obtained.

Characteristics Deep Peninsula (Korea) Deep sea water (from Japan) Intake Depth Depth 800 m Depth 200 m Average temperature 13.1 ℃ Above 20 ℃ Hardness More than 8500 mg / ℓ - Average pH 7.87

Component Content Deep Peninsula (Korea) Deep sea water (from Japan) Calcium (Ca) > 2800 mg / ℓ 1.00% Magnesium (Mg) > 400 mg / ℓ 0.133% Sodium (Na) > 3000 mg / ℓ 426 mg / ℓ Stronium (Sr) > 80 mg / ℓ 426 mg / ℓ Iron (Fe) > 0.24 mg / ℓ 0.281 μg / ℓ Manganese (Mn) > 1.7 mg / ℓ 0.153 μg / ℓ Zinc (Zn) > 0.05 mg / ℓ 0.71 μg / ℓ

As shown in Table 1 and Table 2, the deep peninsula water taken from Korea and the deep sea water taken from the waters of Japan have different characteristics in water intake depth, temperature, hardness, and pH. Looking at the depth of the peninsula, the depth of the peninsula is present in an incomparable amount of less than 100 times, and more than 10000 times. It was confirmed that the phases of the ingredients were different.

Example 5 Preparation of Stress Relief Beverage

The peninsula deep water concentrate of Example 3 prepared as described above was mixed with 0.1 parts by weight and 0.5 parts by weight of an appropriate amount of some food ingredients, 1000 g of citric acid, 100 g of oligosaccharide, 2 g of plum concentrate, and 1 g of taurine, followed by mixing. Purified water was added to prepare a stress relief drink.

Experimental Example 1. Clinical Trial

As a result of taking the above-mentioned stress relief drink as a tide to a test subject (Kim Hana, 32 years old, living in Gangnam-gu, Seoul) who voluntarily tested, the feeling of stress was alleviated compared to before taking, and the energy deterioration due to stress was reduced. The frequency was also significantly reduced.

The pharmaceutical composition of the present invention can be administered in the following formulations, and the following formulation examples are merely illustrative of the present invention, whereby the content of the present invention is not limited.

Formulation Example 1 Preparation of Injection

100 mg of peninsula deep water concentrated powder of Example 3

Sodium Metabisulfite 3.0 mg

Methylparaben 0.8 mg

Propylparaben 0.1 mg

Appropriate sterile distilled water for injection

The above ingredients are mixed and prepared in a conventional manner to have a final volume of 2 ml, and then filled into 2 ml ampoules and sterilized to prepare an injection.

Formulation Example 2 Preparation of Tablet

200 mg of peninsula deep water concentrated powder of Example 3

Lactose 100 mg

Starch 100 mg

Magnesium stearate proper amount

A tablet is prepared by mixing and tableting the above components according to a conventional tablet manufacturing method.

Formulation Example 3 Preparation of Capsule

100 mg of peninsula deep water concentrated powder of Example 3

Lactose 50 mg

Starch 50 mg

Talc 2 mg

Magnesium stearate appropriate amount

According to a conventional capsule preparation method, the above ingredients are mixed and filled into gelatin capsules to prepare capsules.

Formulation Example 4 Preparation of Liquid

1000 mg of peninsula deep water concentrated powder of Example 3

20 g of sugar

20 g of isomerized sugar

Lemon flavor

Purified water was added to adjust the total volume to 1000 ml. According to the conventional method for preparing a liquid, the above components are mixed, and then filled into a brown bottle and sterilized to prepare a liquid.

Formulation Example 5 Preparation of Healthy Food

1000 mg of peninsula deep water concentrated powder of Example 3

Vitamin mixture proper amount

70 μg of Vitamin A Acetate

Vitamin E 1.0 mg

Vitamin B ₁ 0.13 mg

Vitamin B ₂ 0.15 mg

Vitamin B ₆ 0.5 mg

0.2 μg of vitamin B ₁₂

Vitamin C 10 mg

10 μg biotin

Nicotinic Acid 1.7 mg

Folate 50 ㎍

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method. The granules may be prepared and used for preparing a health food composition according to a conventional method.

Formulation Example 6 Preparation of Healthy Drink

1000 mg of concentrated deep water of Example 3

Citric acid 1000 mg

100 g oligosaccharides

Plum concentrate 2 g

1 g of taurine

Add 900 ml of purified water

After mixing the above components according to the conventional healthy beverage production method, and then stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container sterilized sealed and stored in the refrigerator and then the present invention For the preparation of healthy beverage compositions.

Although the composition ratio is mixed composition of a relatively suitable component in a preferred embodiment, the composition ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, use purpose.

The concentrated peninsula provided by the present invention as it is or the concentrate obtained by desalting as it is or concentrated contains abundant minerals, etc., thus reducing the amount of corticosteroid secretion compared to the experimental group that did not administer this concentrate in animal experiments. It can be used as a pharmaceutical composition and health supplement for the stress relief effect, as well as showing the effect on stress relief and defense.

Claims (9)

A pharmaceutical composition for stress relief comprising deep peninsula water or desalted water. A pharmaceutical composition for stress relief comprising a concentrate obtained by concentrating the deep peninsula itself or the desalted one, respectively. The pharmaceutical composition according to claim 1 or 2, wherein the depth of the peninsula is taken at a point 700 to 1000 m underground near the west coast including Gyeonggi-do, South Korea. The pharmaceutical composition according to claim 1 or 2, wherein the pharmaceutical composition contains an inorganic component selected from sodium, calcium, magnesium, potassium, selenium, zinc and the like and a large amount of metal ions selected from iron, manganese, strontium, and the like. The pharmaceutical composition according to claim 1 or 2, comprising 0.01 to 80% by weight of the concentrate obtained as it is or concentrated from the deep water of the peninsula itself or desalted. The pharmaceutical composition according to claim 1 or 2, wherein the composition is a tablet, capsule, solution, suspension or syrup. The pharmaceutical composition according to claim 1 or 2, wherein the daily dosage of the composition is 0.01 to 10 g per kg of body weight. A dietary supplement comprising food supplements which are food acceptable as well as concentrates obtained by intact or concentrated desalination water itself or desalted water showing a stress relieving effect. The food product of claim 8, wherein the health functional food is in the form of a powder, granule, tablet, capsule or beverage.