KR20040096423A - 유방암 예후 진단방법 - Google Patents

유방암 예후 진단방법 Download PDF

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KR20040096423A
KR20040096423A KR1020040028520A KR20040028520A KR20040096423A KR 20040096423 A KR20040096423 A KR 20040096423A KR 1020040028520 A KR1020040028520 A KR 1020040028520A KR 20040028520 A KR20040028520 A KR 20040028520A KR 20040096423 A KR20040096423 A KR 20040096423A
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왕이신
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베리덱스 엘엘씨
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Abstract

본 발명은 유전자 군의 발현을 분석함으로써 실행되는, 유방암(breast cancer)의 예후(prognosis)를 제공하는 방법에 관한 것이다. 마이크로어레이(microarray)와 같은 다양한 매체에서의 유전자 발현 프로파일(profile)과 함께 이들을 함유하는 키트가 포함된다.

Description

유방암 예후 진단방법{BREAST CANCER PROGNOSTICS}
본 발명은 생물 샘플의 유전자 발현 프로파일에 기초하여 유방암을 예후 진단하는 방법에 관한 것이다.
유방암에서는, 주로 배출 겨드랑이 림프절에서의 전이의 유무에 의해 예후를 결정한다. 그러나, 국부적이거나 지엽적인 치료를 받은지 10년 후에, 음성(negative) 림프절을 갖는 유방암 여성의 약 ⅓에서 유방암이 재발하고,양성(positive) 림프절을 갖는 환자의 약 ⅓에서 유방암이 나타나지 않는다. 뿐만 아니라, 경각심이 증가하고 검진 양식이 광범위하게 사용됨으로 인해, 초기 단계에서 유방암이 진단되는 비율이 높아지고 있다. 이들 환자에게 전신 요법을 일반적으로 시행하게 되면 종종 과잉 진료가 이루어지게 된다. St Gallen 및 NIH 컨센서스에 따르면, 제 I 단계 및 제 II 단계 환자의 70 내지 80%가 보조 치료 없이도 원거리 전이가 일어나지 않고, 부작용으로 고생할 수도 있다. 이러한 데이터는 불필요한 치료를 받는 환자의 수를 상당히 감소시킬 수 있는 더욱 민감하고 특이적인 예후 분석법의 필요성을 강조한다.
몇몇 연구에서는, 종양 크기 또는 림프 또는 혈관 침범이 상당한 예후 가치를 갖는 것으로 밝혀졌다. 정량적인 병리학적 특징, 즉 핵 형태, DNA 함량 및 증식 활성이 미세 전이될 가능성이 높은 종양을 추가로 구별해낼 수 있다. 환자의 결과에 영향을 끼치는 공지 분자의 유전자 변화는 Her2/NEU 과발현, DNA 증폭, p53 돌연변이, ER/PR 상태, uPA 및 PAI 발현을 포함한다. 전이 캐스케이드(cascade)가 많은 단계를 포함하는 복잡한 과정이기 때문에, 종양 과정에 기여하는 단일 인자들은 예측 평가시 한계점을 갖는다. 본 발명의 유전자 발현 프로파일은 증가된 예후 효력을 제공할 것이다.
본 발명은 유방암을 갖는 것으로 진단되거나 유방암 치료를 받은 환자에서 유방암이 재발되거나 전이될 가능성을 평가하는 방법을 제공한다. 본 방법은 유전자 발현 프로파일의 분석을 포함한다.
본 발명의 한 양태에서, 유전자 발현 프로파일은 56개의 유전자를 포함한다. 본 발명의 다른 양태에서, 이 프로파일은 각각 45개 이상, 26개, 13개 및 6개의 유전자를 포함한다.
본 방법을 실행하는데 이용되는 물품도 또한 본 발명의 양태이다. 이들 물품은 컴퓨터 판독가능한 매체와 같은 기계-판독가능한 매체에 고정된 유전자 발현 프로파일 또는 이들의 표현물(畵像; representation)을 포함한다.
유전자 발현 프로파일을 확인하는데 사용되는 물품은 또한 유전자 발현의 유무 또는 발현 정도를 포착 및/또는 표시하는 기판 또는 표면(예: 마이크로어레이)도 포함할 수 있다.
본 발명의 또다른 양태에서, 키트는 유방암 재발 또는 전이를 예후 진단하는 유전자 발현 분석을 수행하기 위한 시약을 포함한다.
도 1은 실시예에 기재되어 있는 트레이닝 세트로서의 환자 데이터로부터 구축된 표준 카플란-마이어 플롯(Kaplan-Meier Plot)이다.
도 2는 실시예에 기재되어 있는 시험 세트로서의 환자 데이터로부터 구축된 표준 카플란-마이어 플롯이다.
도 3은 56개의 유전자 발현 프로파일을 사용하여 환자 54명의 환자 데이터(조합된 트레이닝 및 시험 데이터)로부터 구축된 표준 카플란-마이어 플롯이다.
조직 샘플에서의 특정 핵산 서열의 유무는 진단 또는 예후 가치를 거의 갖지 않는 것으로 밝혀져 왔다. 반면, 다양한 단백질, 펩티드 또는 mRNA의 발현에 대한 정보는 점점 중요한 것으로 간주되고 있다. 게놈 내에서 자동적으로 단백질, 펩티드 또는 mRNA를 발현할 가능성이 있는 핵산 서열(예: "유전자"로 일컬어지는 서열)의 존재만으로는 단백질, 펩티드 또는 mRNA가 소정 세포에서 발현되는지의 여부를 결정짓지는 못한다. 단백질, 펩티드 또는 mRNA를 발현할 수 있는 소정 유전자가그렇게 하는지의 여부 및 이러한 발현이 일어나는 경우 그의 정도는 여러 복잡한 인자에 의해 결정된다. 이들 인자를 이해 및 평가함에 있어서의 어려움과는 관계없이, 유전자 발현의 분석은 종양 발생, 전이, 세포자멸사 및 다른 임상적으로 관련된 현상과 같은 중요한 사건의 발생에 대한 유용한 정보를 제공할 수 있다. 유전자의 활성 또는 불활성 정도에 대한 상대적인 지표를 유전자 발현 프로파일에서 찾을 수 있다. 본 발명의 유전자 발현 프로파일을 사용하여 유방암 환자를 예후 및 치료할 수 있다.
샘플 준비에는 환자 샘플 수집이 필요하다. 본 발명의 방법에 이용되는 환자 샘플은 유방 또는 림프절 샘플 또는 수술 마진(surgical margin)로부터 채취한 상피세포와 같은 질병에 걸린 세포를 함유하는 것으로 의심되는 샘플이다. 의심 샘플을 수득하는 한 가지 유용한 기법은 레이저 포획 마이크로다이섹션(Laser Capture Microdisection; LCM)이다. LCM 기법은 세포 유형의 불균질성으로 인해 야기되는 변화를 최소화시키면서 연구할 세포를 선택하는 방법을 제공한다. 결과적으로, 정상 세포와 암세포 사이의 유전자 발현의 온건하거나 작은 변화를 쉽게 검출할 수 있다. 바람직한 방법에서, 샘플은 말초 혈액으로부터 추출된 순환 상피 세포를 포함한다. 이들은 여러 방법에 따라 수득될 수 있으나, 가장 바람직한 방법은 이뮤니베스트 코포레이션(Immunivest Corp)에게 양도된 미국 특허 제 6,136,182 호(본원에 참고로 인용한다)에 기재되어 있는 자기 분리 기법이다. 관심있는 세포를 함유하는 샘플을 수득한 후에는, RNA를 추출 및 증폭시키고, 적절한 포트폴리오(portfolio)의 유전자에 대해 바람직하게는 마이크로어레이를 통하여 유전자 발현 프로파일을 수득한다.
유전자 발현 프로파일을 확립하는 바람직한 방법은 단백질 또는 펩티드를 코딩할 수 있는 유전자에 의해 생성되는 RNA의 양을 결정함을 포함한다. 이는 역전사효소 PCR(RT-PCR), 반복 RT-PCR, 실시간 RT-PCR, 차동 디스플레이 RT-PCR, 노던 블롯(Northern Blot) 분석 및 다른 관련 시험에 의해 달성된다. 개별적인 PCR 반응을 이용하여 이들 기법을 수행할 수도 있지만, 상보적인 DNA(cDNA) 또는 mRNA로부터 생성되는 상보적인 RNA(cRNA)를 증폭시키고 마이크로어레이를 통해 이를 분석하는 것이 가장 좋다. 다수의 상이한 어레이 형상 및 이들의 제조 방법은 당해 분야의 숙련자에게 공지되어 있고, 미국 특허 제 5,445,934 호, 제 5,532,128 호, 제 5,556,752 호, 제 5,242,974 호, 제 5,384,261 호, 제 5,405,783 호, 제 5,412,087 호, 제 5,424,186 호, 제 5,429,807 호, 제 5,436,327 호, 제 5,472,672 호, 제 5,527,681 호, 제 5,529,756 호, 제 5,545,531 호, 제 5,554,501 호, 제 5,561,071 호, 제 5,571,639 호, 제 5,593,839 호, 제 5,599,695 호, 제 5,624,711 호, 제 5,658,734 호 및 제 5,700,637 호와 같은 미국 특허(이들은 본원에 참고로 인용한다)에 기재되어 있다.
마이크로어레이 기법에 의해 수천개의 유전자의 정상상태 mRNA 수준을 측정할 수 있는 동시에, 이로 인해 제어되지 않은 세포 증식의 개시, 정지 또는 조정과 같은 효과를 확인하기 위한 강력한 수단을 제공할 수 있다. 두 가지 마이크로어레이 기법이 현재 널리 이용되고 있다. 첫번째는 cDNA 어레이이고, 두번째는 올리고뉴클레오티드 어레이이다. 이들 칩에는 구성상 차이가 있지만, 본질적으로 모든다운스트림(downstream) 데이터 분석 및 결과는 동일하다. 이들 분석의 결과는 전형적으로 마이크로어레이의 공지 위치에서 핵산 서열에 하이브리드를 형성하는 샘플로부터의 cDNA 서열을 검출하는데 사용되는 라벨링된 프로브로부터 수신되는 신호의 강도 측정치이다. 전형적으로, 신호의 강도는 샘플 세포에 발현된 cDNA, 따라서 mRNA의 양에 비례한다. 다수의 이들 기법이 이용가능하고 유용하다. 유전자 발현을 결정하는데 바람직한 방법은 린슬리(Linsley) 등의 미국 특허 제 6,271,002 호, 프렌드(Friend) 등의 미국 특허 제 6,218,122 호, 펙(Peck) 등의 미국 특허 제 6,218,114 호; 및 왕(Wang) 등의 미국 특허 제 6,004,755 호(이들은 각각 본원에 참고로 인용한다)에서 찾아볼 수 있다.
이러한 강도를 비교함으로써 발현 수준의 분석을 수행한다. 시험 샘플에서의 유전자 발현 강도 대 대조용 샘플에서의 유전자 발현 강도의 비 매트릭스를 제작함으로써 가장 우수하게 이를 수행할 수 있다. 예를 들어, 질병에 걸린 조직으로부터의 유전자 발현 강도를 동일한 유형의 정상 조직으로부터 발생되는 발현 강도와 비교할 수 있다(예를 들어, 질병에 걸린 유방 조직 샘플 대 정상 유방 조직 샘플). 이들 발현 강도의 비는 시험 샘플과 대조용 샘플의 유전자 발현의 배수-변화(fold-change)를 나타낸다.
유전자 발현 프로파일은 또한 여러 방식으로 표시될 수 있다. 가장 통상적인 방법은 손대지 않은 형광 강도 또는 비 매트릭스를 막대 그래프(graphical dendogram)(여기에서, 행은 시험 샘플을 나타내고, 열은 유전자를 나타냄)내로 배열하는 것이다. 유사한 발현 프로파일을 갖는 유전자가 서로 근접하도록 데이터를배열한다. 각 유전자에 대한 발현 비는 색깔로 가시화시킨다. 예를 들어, 1보다 작은 비(하향-변동률을 나타냄)는 스펙트럼의 청색 부분에 나타날 수 있는 반면, 1보다 큰 비(상향-변동률을 나타냄)는 스펙트럼의 적색 부분에 나타날 수 있다. 실리콘 제네틱스, 인코포레이티드(Silicon Genetics, Inc.)의 "GENESPRINT" 및 팔텍, 인코포레이티드(Partek, Inc.)의 "DISCOVERY"와 "INFER"을 비롯한 시판중인 컴퓨터 소프트웨어 프로그램을 사용하여 이러한 데이터를 표시할 수 있다.
본 발명의 방법에 사용되는 조정된 유전자는 실시예에 기재되어 있다. 차별적으로 발현되는 유전자는 재발되지 않은 환자에 대해 유방암이 재발된 환자에서 상향-변동 또는 하향-변동된다. 상향-변동 및 하향-변동은 몇몇 기준선에 대한 유전자의 발현 양에서 검출가능한 차이(이를 측정하는데 사용되는 시스템의 노이즈보다 높은)가 발견됨을 의미하는 상대적인 용어이다. 이 경우, 기준선은 재발되지 않은 환자의 측정된 유전자 발현이다. 질병에 걸린 세포(재발된 환자에서 채취됨)의 관심 있는 유전자는, 동일한 측정 방법을 이용하여 기준선 수준에 대해 상향-변동 또는 하향-변동된다. 이와 관련하여 "질병에 걸린"이란 제어되지 않은 세포 증식과 함께 발생되는 신체 기능의 적절한 작동을 방해하거나 교란하는, 또는 상기 신체 기능의 적절한 작동을 방해할 가능성이 있는 신체 상태의 변화를 일컫는다. 어떤 사람의 유전자형 또는 표현형의 몇몇 양상이 질병의 존재와 일치할 때 이 사람은 질병에 걸린 것으로 진단된다. 그러나, 진단하거나 예후 진단하는 작업은 재발 또는 전이 가능성의 측정과 같은 질병/상태의 결정 및 치료 모니터링을 포함한다. 치료 모니터링의 경우, 유전자 발현 프로파일이 정상 조직과 더욱 일치되는패턴으로 변화했는지 또는 변화하고 있는지의 여부를 결정하기 위해 유전자 발현을 시간의 흐름에 따라 비교함으로써, 소정 치료 과정의 효과와 관련하여 임상적인 결정을 내린다.
바람직하게는, 하이브리드 형성된 마이크로어레이 프로브의 강도 측정치의 배수 변화에 기초하여 상향-변동과 하향-변동 수준을 구별한다. 이렇게 구별하거나 또는 0.05 미만의 p-값을 만드는 데에는 2.0배 차이가 바람직하다. 즉, 유전자가 정상적인/재발되지 않은 세포에 대해 질병에 걸린/재발된 세포에서 차별적으로 발현된다고 결정되기 전에, 질병에 걸린 세포는 정상 세포보다 2배 이상 더 크거나 2배 이상 더 작은 강도를 나타내는 것으로 밝혀졌다. 배수 차이가 클수록 유전자를 진단 또는 예후 수단으로 사용하는 것이 더욱 바람직하다. 본 발명의 유전자 발현 프로파일을 위해 선택된 유전자는 임상 실험실 장치를 사용한 바탕치를 초과하는 양만큼 정상적이거나 조정되지 않은 유전자의 신호로부터 구별될 수 있는 신호를 발생시키는 발현 수준을 갖는다.
통계치를 사용하여, 조정된 유전자를 조정되지 않은 유전자 및 노이즈로부터 신뢰성있게 구별할 수 있다. 통계 시험에서는 다양한 샘플 군 사이에서 가장 크게 상이한 유전자를 찾아낸다. 스튜던츠(Student's) t-시험이 두 군간의 유의한 차이를 발견하는데 사용될 수 있는 강력한 통계 시험의 일례이다. p-값이 낮을수록, 상이한 군 사이에서 유전자가 차이를 나타내는 증거가 더욱 신빙성을 갖게 된다. 그럼에도 불구하고, 마이크로어레이가 한 번에 하나보다 많은 유전자를 측정하기 때문에 수천가지의 통계 시험중 10가지가 한꺼번에 요청될 수 있다. 이 때문에,작은 p-값을 우연히 발견할 가능성은 낮으며, 시닥(Sidak) 보정 및 무작위화/순열 실험을 이용하여 이를 조정할 수 있다. t-시험에 의해 0.05보다 작은 p-값은 유전자가 상당히 상이하다는 증거이다. 더욱 신빙성있는 증거는 시닥 보정을 수행한 후에 0.05보다 작은 p-값이다. 각 군의 다수의 샘플에 있어서, 무작위화/순열 시험 후 0.05보다 작은 p-값은 유의한 차이의 가장 신빙성 있는 증거이다.
조정되지 않은 유전자의 신호 또는 노이즈보다 큰 신호를 발생시키는 유전자를 선택하는데 이용될 수 있는 다른 매개변수는 절대 신호 차이의 측정치를 이용하는 것이다. 바람직하게는, 조정된 유전자 발현에 의해 발생된 신호는 정상적인 유전자 또는 조정되지 않은 유전자의 신호와 20% 이상 상이하다(절대 기준). 이러한 유전자가 정상적인 유전자 또는 조정되지 않은 유전자의 신호와 30% 이상 상이한 발현 패턴을 생성시키는 것이 더더욱 바람직하다.
각 군의 유전자 세트에 대해 수득된 정보가 진단, 예후 또는 치료 선택과 같은 임상적으로 관련된 판단을 내리는 견실한 기준을 제공하도록 유전자를 군으로 묶을 수 있다. 이들 유전자 세트는 본 발명의 포트폴리오를 구성한다. 이 경우, 포트폴리오에 의해 지지되는 판단은 유방암을 포함한다. 대부분의 진단 마커에서와 같이, 올바른 의학적 판단을 내리기에 충분한 최소 갯수의 마커를 사용하는 것이 종종 바람직하다. 이로 인해, 치료에 관련된 다른 분석의 지연을 방지할 뿐만 아니라 시간과 자원의 부적절한 사용을 방지한다.
바람직하게는, 포트폴리오의 유전자의 조합이 개별적인 유전자 또는 무작위적으로 선택된 유전자의 조합에 비해 개선된 민감도 및 특이성을 나타내도록 포트폴리오를 수립한다. 본 발명에서는, 포트폴리오의 민감도가 정상적인 상태에 비해 질병에 걸린 상태의 유전자 발현에 의해 나타나는 배수 차이에 반영될 수 있다. 특이성은 관심있는 질병과 유전자 발현 신호의 상관관계의 통계적인 측정치에 반영될 수 있다. 예를 들어, 표준 편차를 이러한 측정에 사용할 수 있다. 포트폴리오에 포함시키기 위하여 유전자 군을 고려할 때에는, 발현 측정치의 작은 표준 편차가 보다 큰 특이성과 관련된다. 상관 계수와 같은 다른 변화 측정치를 이를 위해 사용할 수 있다.
유전자 발현 포트폴리오를 수립하는 바람직한 방법은 스톡(stock) 포트폴리오를 수립하는데 널리 사용되는 평균 평방 편차 연산과 같은 최적화 연산을 사용하는 것이다. 이 방법은 2003년 3월 21일자로 팀 잿코(Tim Jatkoe) 등이 출원한 미국 특허출원 10/394087 호(발명의 명칭: "마커의 선택")(본원에 참고로 인용한다)에 상세하게 기재되어 있다. 구체적으로, 이 방법은 회답의 가변성을 최소화하면서 이를 사용하기 위해 수용하는 회답(예컨대, 발생되는 신호)을 최적화하는 입력치 세트(재정 용도의 스톡, 여기에서는 강도로 측정되는 발현)의 수립을 필요로 한다. 이를 수행하는데 많은 시판중인 소프트웨어 프로그램을 이용할 수 있다. 본 명세서에서 "와그너 소프트웨어(Wagner Software)"라고 불리는 "와그너 어쏘시에이츠 평균-평방 편차 최적화 응용"이 바람직하다. 이 소프트웨어는 "와그너 어쏘시에이츠 평균-평방 편차 최적화 라이브러리"로부터의 기능을 이용하여 유효 영역(efficient frontier) 및 최적 포트폴리오를 결정한다.
이러한 유형의 소프트웨어를 사용하려면, 회수 스톡 방식의 입력치로서 취급될 수 있도록 마이크로어레이 데이터(즉, 강도 측정치)를 변형시켜야 하고, 이 소프트웨어를 원래의 재정 분석 용도로 사용할 때에는 위험 측정치를 사용한다.
포트폴리오 선택 및 미지 유전자의 특징 결정 과정은 다음과 같이 요약된다:
1. 기준선 부류를 선택한다.
2. 기준선 부류 샘플에 있어서 각 유전자의 평균 및 표준 편차를 계산한다.
3. 각 유전자에 대해 계산한다(X*표준 편차+평균). 이는 다른 모든 샘플을 비교하는 기준선 판독치이다. X는 설득력 변수로서, 큰 X 값은 작은 것보다 더욱 설득력있다.
4. 단계 3에서 계산된 기준선 판독치에 대한 각 실험 샘플의 비를 계산한다.
5. 1보다 작은 비가 음성이도록 비를 변형시킨다(예컨대, Log10을 사용함). (이제, 하향-변동된 유전자는 MV 최적화에 필요한 음의 값을 갖는다.)
6. 소프트웨어 용도에 통상적으로 사용되는 자산 회수분 대신 이들 변형된 비를 입력치로서 사용한다.
7. 소프트웨어는 유효 영역을 플롯팅하고 유효 영역을 따라 임의의 시점에서 최적화된 포트폴리오를 답변하게 된다.
8. 유효 영역에서 목적하는 답변 또는 평방 편차를 선택한다.
9. 각 유전자의 강도값을 포트폴리오 선택 연산에 의해 생성된 중량으로 곱한 값을 더함으로써, 각 샘플에 대한 포트폴리오 값을 계산한다.
10. Y와 기준선 포트폴리오 값의 표준 변차의 곱에 기준선 군의 평균 포트폴리오값을 더함으로써, 한계 값을 계산한다. 이 한계 값보다 큰 값은 실험 부류로 분류될 것이다.
11. 임의적으로는, 최선의 예측 정확도가 얻어질 때까지 이 과정을 반복할 수 있다.
다르게는, 발현이 몇몇 차별화 최소 수준을 나타내는 유전자를 확인함으로써, 유전자를 먼저 예비-선택할 수 있다. 이 다른 방법에서의 예비-선택은 바람직하게는 하기 수학식 1에 의해 주어지는 역치에 기초한다:
상기 식에서,
μ l 은 질환 또는 질병을 갖는 것으로 알려진 서브세트(subset)의 평균이고,
μ n 은 정상 샘플의 서브세트의 평균이며,
σ l +σ n 은 합해진 표준 편차를 나타낸다.
하기 수학식 2와 같은 관계에 따라 데이터를 예비-선택함으로써, 신호 대 노이즈 컷오프(cutoff)를 사용할 수도 있다:
이는, 차별적인 조정에 기초하여 예비-선택된 유전자가 임상적으로 유의한 방식으로 차별화되도록 한다. 즉, 장치의 노이즈 수준보다 높으면 진단 매개변수의 측정 과제에 적절하다. 이러한 기준에 따라 예비-선택된 각 마커에 대해, 매트릭스(여기에서, 행은 샘플을 나타내고, 열은 마커를 나타냄)를 수립하며, 각 원소는 하기 수학식 3의 관계에 따른 마커의 발현에 대해 정규화된 강도 측정치이다:
상기 식에서, I는 강도 측정치이다.
최적 포트폴리오를 규정하기 위하여 추가적인 한계 조건을 설정할 수도 있다. 예를 들어, 포트폴리오 크기를 고정된 범위 또는 수의 마커로 한정시킬 수 있다. 데이터 예비-선택 기준을 더욱 엄격하게 함으로써(예를 들어,대신), 또는 포트폴리오 크기를 제한하는 것과 같은 프로그래밍 특징을 이용함으로써 이를 수행할 수 있다. 예를 들어, 유효 영역이 가장 최적인 10개 유전자 가운데에서만 선택되도록 한계 조건을 설정할 수 있다. 또한, 유효 영역을 결정하기 위해 예비-선택된 유전자를 모두 사용한 다음 선택된 유전자의 수를 한정(예컨대, 10개 이하)할 수도 있다.
포트폴리오를 선택하는 과정은 또한 발견 규칙의 적용을 포함할 수 있다. 바람직하게는, 이러한 규칙은 생물학 및 임상 결과를 산출하기 위해 이용되는 기법의 이해에 기초하여 공식화된다. 더욱 바람직하게는, 이들 규칙을 최적화 방법의결과에 적용시킨다. 예를 들어, 포트폴리오 선택의 평균 평방 편차 방법을 유방암 환자에서 차별적으로 발현되는 다수의 유전자에 대한 마이크로어레이 데이터에 적용할 수 있다. 이 방법으로부터의 결과는 질병에 걸린 조직뿐만 아니라 말초 혈액에서 발현되는 몇몇 유전자를 포함할 수 있는 최적화된 유전자 세트일 수 있다. 시험 방법에 사용되는 샘플이 말초 혈액으로부터 수득되고 유방암의 경우에 차별적으로 발현되는 특정 유전자가 말초 혈액에서도 차별적으로 발현될 수 있다면, 말초 혈액에서 차별적으로 발현되는 것을 제외한 유효 영역으로부터 포트폴리오를 선택하는 발견 규칙을 적용할 수 있다. 물론, 예컨대 데이터 예비-선택동안 규칙을 적용함으로써 유효 영역 형성 전에 이 규칙을 적용할 수 있다.
해당 생물학에 반드시 관련되지 않은 다른 발견 규칙을 적용할 수 있다. 예를 들어, 포트폴리오의 소정 비율만이 특정 유전자 또는 유전자들을 대표할 수 있는 규칙을 적용할 수 있다. 와그너 소프트웨어와 같은 시판중인 소프트웨어는 이러한 유형의 발견 규칙을 용이하게 수용한다. 이는, 예컨대 정확도 및 정밀도 외의 인자(예: 예정된 인가료)가 하나 이상의 유전자를 바람직하게 포함함에 영향력을 가질 때, 유용할 수 있다.
본 발명의 한 방법은 예후에 기여하는 다양한 유전자(또는 포트폴리오)에 대한 유전자 발현 프로파일을 비교함을 포함한다. 포트폴리오를 구성하는 유전자 각각의 유전자 발현 프로파일은 컴퓨터 판독가능한 매체와 같은 매체에 고정된다. 이는 여러 형태를 취할 수 있다. 예를 들어, 질병/재발을 표시하는 신호의 범위(예컨대, 강도 측정치)를 입력한 표를 구축할 수 있다. 그 다음, 실제 환자 데이터를 표에 기재된 값과 비교하여 환자 샘플이 정상인지 질병에 걸렸는지의 여부를 결정할 수 있다. 더욱 복잡한 실시태양에서는, 발현 신호(예컨대, 형광 강도)의 패턴을 디지털 방식으로 또는 도식으로 기록한다. 이어, 환자 샘플과 함께 사용되는 유전자 포트폴리오로부터의 유전자 발현 패턴을 발현 패턴과 비교한다. 패턴 비교 소프트웨어를 사용하여 환자 샘플이 질병의 재발을 나타내는 패턴을 갖는지의 여부를 결정할 수 있다. 물론, 이렇게 비교함으로써 환자가 질병 재발을 겪을 가능성이 있는지의 여부를 결정할 수도 있다. 샘플의 발현 프로파일을 대조용 세포의 포트폴리오와 비교한다. 샘플 발현 패턴이 유방암 재발의 발현 패턴(대항하는 의학적 고려사항의 부재하에)과 일치한다면, 재발 환자를 치료하는 것처럼 환자를 치료한다. 샘플 발현 패턴이 정상/대조용 세포로부터의 발현 패턴과 일치한다면, 환자는 유방암에 대해 음성으로 진단된다.
다수의 널리 공지된 패턴 인식 방법을 이용할 수 있다. 하기 참조문헌은 몇몇 예를 제공한다:
가중 결정:
골럽(Golub, TR.), 슬로님(Slonim, DK.), 타마야(Tamaya, P.), 후어드(Huard, C.), 가젠빅(Gaasenbeek, M.), 메시로프(Mesirov, JP.), 칼러(Coller, H.), 로(Loh, L.), 다우닝(Downing, JR.), 칼리귀리(Caligiuri, MA.), 블룸필드(Bloomfield, CD.), 랜더(Lander, ES.)Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286:531-537, 1999
지지체 벡터 머신:
수(Su, AI.), 웰쉬(Welsh, JB.), 사피노소(Sapinoso, LM.), 케른(Kern, SG.), 디미트로프(Dimitrov, P.), 랩(Lapp, H.), 슐츠(Schultz, PG.), 포웰(Powell, SM.), 모스칼룩(Moskaluk, CA.), 프리어슨, 쥬니어(Frierson, HF, Jr.), 햄프턴(Hampton, GM.)Molecular classification of human carcinomas by use of gene expression signatures. Cancer Research 61:7388-93, 2001
라마스와미(Ramaswamy, S.), 타마요(Tamayo, P.), 리프킨(Rifkin, R.), 무커지(Mukherjee, S.), 에앙(Yeang, CH.), 앤젤로(Angelo, M.), 래드(Ladd, C.), 라이히(Reich, M.), 라투리프(Latulippe, E.), 메시로프(Mesirov, JP.), 포지오(Poggio, T.), 제랄드(Gerald, W.), 로다(Loda, M.), 랜더(Lander, ES.), 굴드(Gould, TR.)Multiclass cancer diagnosis using tumor gene expression signatures. Proceedings of the National Academy of Sciences of the USA 98:15149-15154, 2001
K-가장 근접한 유사체:
라마스와미(Ramaswamy, S.), 타마요(Tamayo, P.), 리프킨(Rifkin R.), 무커지(Mukherjee, S.), 에앙(Yeang, CH.), 앤젤로(Angelo, M.), 래드(Ladd, C.), 라이히(Reich, M.), 라투리프(Latulippe, E.), 메시로프(Mesirov, JP.), 포지오(Poggio, T.), 제랄드(Gerald, W.), 로다(Loda, M.), 랜더(Lander, ES.), 굴드(Gould, TR.)Multiclass cancer diagnosis using tumor gene expression signatures. Proceedings of the National Academy of Sciences of the USA98:15149-15154, 2001
상관 계수:
반 비어(van't Veer LJ), 다이(Dai H), 반 드 비즈버(van de Vijver MJ), 헤(He YD), 하트(Hart AA), 마오(Mao M), 피터스(Peterse HL), 반 데어 코이(van der Kooy K), 마튼(Marton MJ), 위트빈(Witteveen AT), 쉬라이버(Schreiber GJ), 커크호벤(Kerkhoven RM), 로버츠(Roberts C), 린슬리(Linsley PS), 버나즈(Bernards R), 프렌드(Friend SH). Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002년 1월 31일; 415(6871):530-6.
암 진단, 예후 또는 치료 모니터링에 유용한 다른 비-유전자적 진단 방법과함께 본 발명의 유전자 발현 프로파일을 사용할 수도 있다. 예컨대, 몇몇 상황에서는, 상기 기재된 유전자 발현에 기초한 방법의 진단 효력을 혈청 단백질 마커와 같은 종래의 마커로부터의 데이터와 조합하는 것이 유리하다. 에스트로겐 수용체(ER)와 같은 분석물을 포함하는 다양한 마커가 존재하는데, ER+ 결과는 재발 또는 전이 가능성이 더 큼을 나타낸다. 미국 특허 제 5,693,465 호(본원에 참고로 인용한다)에 기재되어 있는 바와 같이, 에스트로겐 조절되는 유전자 서열 pLIV1에 의해 생산되는 단백질(또는 펩티드)과 같은 다른 마커를 이러한 용도로 사용할 수 있다. 이러한 한 방법에서는, 치료된 환자로부터 혈액을 주기적으로 채취한 다음 하나 이상의 혈청 마커에 대해 효소 면역분석을 실시한다. 마커(들)의 농도가 암 재발 또는 치료 실패를 암시하는 경우에는, 유전자 발현 분석을 실시할 수 있는 샘플 공급원을 채취한다. 의심스러운 덩어리가 존재하는 경우에는, 미세 바늘로 흡입한 다음 이 덩어리로부터 채취한 세포의 유전자 발현 프로파일을 상기 기재된 바와 같이 분석한다. 다르게는, 종양이 이미 제거된 조직에 인접한 구역으로부터 조직 샘플을 채취할 수도 있다. 다른 시험에서 분명하지 않은 결과가 나올 경우에 이 방법이 특히 유용할 수 있다.
본 발명의 물품은 질병을 치료, 진단, 예후 및 그외 평가에 유용한 유전자 발현 프로파일의 표현물을 포함한다. 이들 프로파일 표현물을 기계에 의해 자동적으로 판독될 수 있는 매체, 예컨대 컴퓨터 판독가능한 매체(자기, 광학 등)로 만든다. 물품은 또한 이러한 매체에서 유전자 발현 프로파일을 평가하기 위한 지침서도 포함할 수 있다. 예를 들어, 물품은 상기한 유전자 포트폴리오의 유전자 발현 프로파일을 비교하기 위한 컴퓨터 지침서를 갖는 CD ROM을 포함할 수 있다. 상기 물품은 또한 환자 샘플로부터의 유전자 발현 데이터와 비교할 수 있도록 디지털 방식으로 기록된 유전자 발현 프로파일을 가질 수 있다. 다르게는, 다양한 표시 포맷으로 프로파일을 기록할 수 있다. 그래프 기록이 이러한 포맷중 하나이다. 상기한 팔텍 인코포레이티드의 "DISCOVERY" 및 "INFER" 소프트웨어에 포함된 것과 같은 클러스터 연산은 이러한 데이터를 가시화시키는데 가장 우수하게 작동할 수 있다.
본 발명에 따른 상이한 유형의 물품은 유전자 발현 프로파일을 시현시키는데 사용되는 매체 또는 포맷화된 분석법이다. 이들은 예를 들어 매트릭스(여기에 관심있는 유전자를 표시하는 서열이 결합하여 이들의 존재에 대한 판독가능한 결정요소를 만들어냄)에 서열 상보물 또는 프로브가 고정되어 있는 마이크로어레이를 포함할 수 있다. 다르게는, 본 발명의 물품은 하이브리드 형성, 증폭 및 유방암을 검출하기 위해 해당 유전자의 발현 수준을 나타내는 신호 발생을 수행하기 위한 시약 키트로 만들어질 수 있다.
본 발명에 따라 제조된 키트는 유전자 발현 프로파일을 결정하기 위한 포맷화된 분석법을 포함한다. 이들은 시약 및 지침서와 같은, 분석을 수행하는데 필요한 재료를 모두 또는 일부 포함할 수 있다.
하기 비제한적인 실시예에 의해 본 발명을 추가로 예시한다.
실시예
본 발명에 따라 분석되는 유전자는 전형적으로 단백질 또는 펩티드의 생산을 코딩하는 완전한 길이의 핵산 서열에 관련되어 있다. 당해 분야의 숙련자는 분석 관점으로 보아 완전한 길이의 서열을 확인할 필요가 없음을 알 것이다. 즉, 프로브가 상응하는 유전자의 유전자 발현을 평가하도록 디자인될 수 있는 널리 공지된 원칙에 따라 서열 또는 EST의 일부를 선택할 수 있다.
실시예 1 - 샘플 취급 및 LCM
유방암 수술을 받은 환자로부터 신선한 냉동 조직 샘플을 수집하였다. 사용된 샘플은 149명의 제 I 단계 및 제 II 단계(표준 임상 진단학 및 병리학에 따른 단계) 환자의 샘플이었다. 환자의 임상 결과는 공지되어 있었다. 환자중 74명은 7년이 넘게 질병이 없는 상태인 반면, 75명의 환자는 4년 내에 원거리 전이되었다.103명의 환자는 림프절 음성인 반면 46명은 림프절 양성이었다.
수획하는 20 내지 30분 내에 액체 질소에서 조직을 급속 냉각시킨 다음 -80℃에서 저장하였다. 레이저 포획을 위하여, 샘플을 절단하고(6㎛), 한 조각은 유리 슬라이드 위에 장착하고 두번째 조각은 필름(P.A.L.M.) 위에 놓았으며, 이 필름을 유리 슬라이드(마이크로 슬라이즈 컬러프로스트, VWR 사이언티픽(Scientific), 펜실바니아 메디아) 위에 고정시켰다. 유리 슬라이드 위에 장착한 조각을 차가운 아세톤 중에서 고정시키고 메이여의 하에마톡실린(Mayers' Haematoxylin)(시그마(Sigma), 미주리주 세인트 루이스)으로 염색하였다. 병리학자들이 진단하고 등급을 매기기 위해 샘플을 분석하였다. 종양의 단계를 조회하기 위하여 첨부된 외과 병리학 및 임상 보고서로부터 임상 단계를 추정하였다. 필름에 장착된 조각을 100% 에탄올 중에서 5분간 고착시킨 다음, 에오신/100% 에탄올(탈수 에탄올 100ml중 에오신 100μg) 중에서 1분동안 역염색시키고, 100% 에탄올 중에 1회 신속하게 침지시켜 유리 염색약을 제거한 다음 10분간 공기 건조시켰다.
LCM에 사용하기 전에, RN아제를 제거하고 조직 샘플의 필름으로의 부착을 향상시키기 위해 막(LPC-MEMBRANE PEN FOIL 1.35㎛ No 8100, P.A.L.M. 게엠베하 마이크로레이저 테크놀로지(P.A.L.M. GmbH Mikrolaser Technologie), 독일 베른리트) 및 슬라이드를 예비 처리하였다. 간략하게, 슬라이드를 DEP H2O에서 세척하고, 필름을 RN아제 어웨이(RNase AWAY)(몰레큘라 바이오프로덕츠, 인코포레이티드(Molecular Bioproducts, Inc.), 캘리포니아주 샌디에고)에서 세척한 다음 DEP H2O에서 세정하였다. 필름을 유리 슬라이드 위에 부착한 다음, 슬라이드를 +120℃에서 8시간동안 소성시키고, TI-SAD(다이아그노스틱 프로덕츠 코포레이션(Diagnostic Products Corporation), 캘리포니아주 로스앤젤레스, DEP H2O중 1:50, 탈지면을 통해 여과시킴)로 처리한 후, +37℃에서 30분간 배양하였다. 사용 직전에, RN아제 저해제 용액(Rnasin Inhibitor 2500U=33U/㎕ N211A, 프로메가 게엠베하(Promega GmbH), 독일 만하임; NaCl 0.15몰, Tris pH 8.0 10밀리몰, 디티오트레이톨 0.25밀리몰을 함유하는 냉동 용액 400㎕중 0.5㎕) 10㎕ 분취량을, 조직 샘플이 장착될 필름에 펴 발랐다.
필름에 장착된 조직 조각을 LCM에 사용하였다. 자이스 악시오버트(Zeiss Axiovert) 135 현미경(칼 자이스 예나 게엠베하(Carl Zeiss Jena GmbH), 독일 예나)내로 연결된 PALM 로봇-마이크로빔 기법(P.A.L.M. 마이크로레이저 테크놀로지, 칼 자이스, 인코포레이티드(Carl Zeiss, Inc.), 뉴욕주 쏜우드)을 사용하여 약 2000개의 상피 세포/샘플을 포획하였다. 정상 점막내의 주위 간질(stroma) 및 암 샘플에 우연히 개입된 간질 성분이 포함되었다. 포획된 세포를 100% 에탄올 중에서 관에 넣고 -80℃에서 보존하였다.
실시예 2 - RNA 추출 및 증폭
자이모-스핀 칼럼(Zymo-Spin Column)(자이모 리써치(Zymo Research), 캘리포니아주 92867 오렌지)을 사용하여 LCM 포획된 샘플로부터 총 RNA를 추출하였다.총 RNA중 약 2ng을 물 10㎕에 재현탁시키고, T7 RNA 폴리머라제에 기초한 증폭을 2회 수행하여 증폭된 RNA 약 50㎍을 수득하였다.
실시예 3 - cDNA 마이크로어레이 하이브리드 형성 및 정량
약 23,000개의 인간 cDNA 클론으로 이루어진 cDNA 마이크로어레이 세트를 사용하여, 아피메트릭스, 인코포레이티드(Affymetrix, Inc.)에서 수득 및 구입한 인간의 U133a 칩을 사용함으로써 샘플을 시험하였다. 상기에서 개략적으로 기재된 바와 같이 총 RNA를 수득 및 준비하고, 칩에 적용하여 제조업체의 프로토콜에 따라 아질렌트 바이오애널라이저(Agilent BioAnalyzer)에 의해 분석하였다. 149개의 샘플이 모두 품질 제어 기준을 통과하였고, 마커 선택에 데이터를 이용하였다.
103명의 림프절 음성 환자를 분석함으로써 마커를 선택하였다. 원거리 전이 및 생존을 식별할 수 있는 유전자를 콕스(Cox) 정비례 위험 모델을 이용하여 확인하였다. 아피메트릭스, 인코포레이티드로부터 구입할 수 있는 MAS 버젼 5.0 소프트웨어("MAS 5.0")를 사용하여 칩 강도 데이터를 분석하였다. 통제되지 않은 분석을 먼저 수행한 다음 통제되는 분석을 수행하였다.
기재된 바와 같이 수득된 칩 강도 데이터는 PARTEK 버젼 5.1 소프트웨어로서 시판중인 통제되지 않은 클러스터 소프트웨어용 입력치이다. 이 통제되지 않은 클러스터 연산은 에스트로겐 수용체를 포함하는 다수의 유전자가 상당히 낮게 발현된 환자 22명의 군을 확인하였다. ER/PR은 유방암에서 불량한 결과를 나타내는 것으로 알려진 예후 인자이며, 따라서 환자 22명의 이 군을, 예후 표시자로서 독립적인값을 갖는 추가적인 인자(유전자 마커)를 확인하기 위한 후속 분석에서 제외시켰다. 연령 및 종양 크기 등의 잘-특성화된 예후 표시자의 잠재적인 효과를 배제하기 위하여 나머지 81명의 환자를 추가로 추려내었다. 이에 따라, 55세보다 연령이 많거나 종양이 5cm보다 큰 27명의 환자를 제외시켰다.
콕스 정비례 위험 모델을 유전자 선택에 사용하였다. 총 31 싸이클의 매 싸이클에서, 트레이닝 세트의 환자 31명 각각을 유지시키고, 환자 생존 시간과 유전자 발현의 제휴 강도를 평가하기 위하여 단일변량 콕스 모델 회귀에 나머지 26명의 환자를 이용하였다. 상응하는 평가된 표준화된 매개변수 추정치 및 콕스 모델 회귀로부터 회송된 P 값에 의해 이러한 제휴의 강도를 평가하였다. 하나씩 제외시키는(leave-one-out) 유전자 선택의 각 싸이클로부터 최상 유전자를 선택하기 위한 역치로서 0.01의 P 값을 사용하였다. 하나씩 제외시키는 총 31회의 유전자 선택 싸이클에서 28회 이상 나타난 유전자를 선택하기 위하여, 각 싸이클로부터 선택된 최상 유전자를 비교하였다. 총 56개의 유전자가 선택되었다. 서열 식별 번호 1 내지 26 및 서열 식별 번호 56의 유전자의 유전자 발현은 2배 이상 상향-변동되었고, 서열 식별 번호 27 내지 55의 유전자의 유전자 발현은 2배 이상 하향-변동되었다.
다중-유전자 예측자(predictor)의 구축 : 예측 지수는 유전자 56개의 발현 값(log 10에 기초함)과 이들의 상응하는 콕스 모델 매개변수 추정치의 곱의 합으로서 정의된다. 콕스 모델로부터의 매개변수 추정치는 유전자 발현 값이 증가할 때 환자의 위험 비를 측정한다. 따라서, 이 지수를 사용한 등급이 높은 환자는 생존 결과가 불량하다. 이 예측 지수를 트레이닝 세트에 적용하여 예측 정확도의 어림값을 수득하였다(도 1).
예측자의 교차-확인 및 평가 : 대부분의 분류 방법은 이들의 수립에 사용된 실시예에서 잘 작동하므로, 독립적인 데이터 세트에 대해 예측자의 성능을 결정하여야 한다. 예측 정확도를 평가하기 위해 환자 23명의 시험 세트를 이용하였다. 90% 민감도를 갖는 ROC 곡선을 사용하여 분류 컷오프를 결정한다. 선택된 컷오프에 기초하여, 시험 세트의 재발 및 생존 환자에 대한 정확한 예측 수치가 표 1에 요약되어 있다. 예측된 재발 환자 및 생존 환자에 대해 카플란-마이어 곡선을 구축하였다(도 2).
전반적인 예측 : 제 I 단계 및 제 II 단계 유방암 환자 54명의 유전자 발현 프로파일에 의해 이들 환자에서 차별적인 발현을 나타내는 유전자 56개를 확인하였다. 환자중 36명은 7년 넘게 질환이 없는 상태인 반면, 환자 27명은 4년 내에 원거리 전이를 나타내었다. 56개-유전자 예측자를 사용하여, 27명의 재발 환자중 22명, 질병이 없는 환자 36명중 27명을 올바르게 확인하였다. 이러한 결과는 82%의 민감도 및 75%의 특이성을 나타낸다. 양성 예측값은 71%이고, 음성 예측값은 84%이다(표 2). 예측된 원거리 전위 환자 및 생존 환자에 기초하여 카플란-마이어 곡선을 구축하였다(도 3).
70개-유전자 예측자를 구축하여 제 I 단계 및 제 II 단계 림프절 음성 유방암에서 환자 결과를 예측한 독립적인 연구가 이미 개시되어 있다(반 비어 등,Nature415, 530-535; 비즈버 등,NEJM347, 1999-2009). 반 비어 등의 연구에 이용된 유전자 70개와 본 명세서의 56개 유전자 예측자 사이에는 1개의 유전자만 겹칠 뿐이다.
실시예 4 - 추가적인 포트폴리오
56개 유전자 포트폴리오를 상이하게 처리하여, 분석을 위한 유전자 발현 신호 수가 보다 적은 임상적으로 유의한 이점을 제공하는 다른 포트폴리오를 만들었다.
a. 1차 처리시에는, 스피어맨(Spearman) 등급 상호관계 및 피어슨(Pearson's) 상호관계에 의해 유전자 56개 사이의 상관 계수를 계산하였다.상관 컷오프로서 0.7을 사용하여, 조정된 유전자 45개의 포트폴리오를 작성하였다. 유전자는 표 4에 기재되어 있다.
b. 2차 처리시에는, 트레이닝 또는 시험 데이터 세트를 사용하여 56개의 유전자를 t-시험하였다. 트레이닝 데이터 및 시험 데이터 둘 다에서 상당한 p 값(< 0.05)을 표시하는 유전자를 포트폴리오로서 선택하였다. 이렇게 하여, 조정된 유전자 26개의 포트폴리오를 작성하였다. 유전자는 표 5에 기재되어 있다.
c. 포트폴리오에 있는 유전자의 공지된 생물학적 기능에 기초하여 (b) 및 표 5의 26개 유전자 포트폴리오를 평가하였다. 전이 경로에 대해 생물학적 관계를 갖는 것을 선택하였다. 이렇게 하여, 조정된 유전자 13개의 포트폴리오를 수립하였다. 유전자는 표 6에 기재되어 있다.
d. 56개 유전자 포트폴리오로부터 가장 우수한 분류 성능을 나타내는 두 유전자 쌍을 선택하였다. 연속해서, 포트폴리오에 하나의 추가적인 유전자를 첨가하고, 이 신호의 첨가가 두 유전자 조합의 트레이닝 세트 및 시험 세트 둘 다에서 전체적인 분류 정확도를 개선시키는지의 여부를 결정하기 위해 시험하였다. 더 이상 개선되지 않을 때까지 이 절차를 반복하였다. 조정된 유전자 6개의 포트폴리오를 확립하였다. 유전자는 표 7에 기재되어 있다.
표 4 내지 표 7에 기재되어 있는 포트폴리오 각각의 민감도 및 특이성은 상기 기재된 샘플의 공지 결과 대 예측된 결과에 기초하여 결정하였다. 이들 값은 표 8 내지 표 11에 기재되어 있다.
본 발명의 방법에 따르면, 유방암을 갖는 것으로 진단되거나 유방암 치료를 받은 환자에서 유방암이 전이 또는 재발될지의 여부를 보다 정확하게 예후할 수 있다.
SEQUENCE LISTING <110> Wang, Yixin <120> Breast Cancer Prognostics <130> CDS 5007 <160> 56 <170> PatentIn version 3.1 <210> 1 <211> 533 <212> DNA <213> Human <400> 1 aaaggcccat taacttaatt taaatgttcc catccttatg aatttactca ctaaggaaaa 60 ctataagctc agattttaca aacaaaagca acttacaagg tattattgct ggtcctttat 120 cccttctctt taatgcaatc tcaaaggttt tttggctatt agttttcata attttcttat 180 gttgcacaca aaaacaagat tcctctctaa aacgtagagg atggggaaaa tgcagatgct 240 gtttttccaa ctaaaaatgt ttacaaaaga acagactgtc tgaacaaaca aaaaaacccc 300 accccgttaa gctgggtagg accaatcagg ccttataagt gaaaaaaaag ccttctatcg 360 agcataatga aacagaacat gtactgcttg tgtttgaacc ttactcttat ttaaccaaaa 420 atttcccctt tctcataatt ttcctagtat tatgtaaggt tatgcctagt tctagattct 480 gaaagacctg cattttaatg cttgcacaac ccatttaaaa tctacaaaag ctg 533 <210> 2 <211> 1450 <212> DNA <213> Human <400> 2 cgtcggcggc cgcggccggg gacggtgtga gagcggtaag atggcggcgg cggcggtggt 60 ggagttccag agagcccagt ctctactcag caccgaccgg gaggcctcca tcgacatcct 120 ccactccatc gtgaagcgtg acattcagga aaacgatgaa gaggcagtgc aagtcaaaga 180 gcagagcatc ctggaactgg gatctctcct ggcaaagact ggacaagctg cagagcttgg 240 aggactcctg aagtatgtac gacccttctt gaattccatc agcaaggcta aagcagctcg 300 cctggtccga tctcttcttg atctgtttct tgatatggaa gcagctacag ggcaggaggt 360 cgagctgtgt ttagagtcca tcgaatgggc caagtcagag aaaagaactt tcttacgcca 420 agctttggag gcaagactgg tgtctttgta ctttgatacc aagaggtacc aggaagcatt 480 gcatttgggt tctcagctgc tgcgggagtt gaaaaagatg gacgacaaag ctcttttggt 540 ggaagtacag cttttagaaa gcaaaacata ccatgccctg agcaacctgc cgaaagcccg 600 agctgcctta acttctgctc gaaccacagc aaatgccatc tactgccccc ctaaattgca 660 ggccaccttg gacatgcagt cgggtattat ccatgcagca gaagagaagg actggaaaac 720 tgcgtactca tacttctatg aggcatttga gggttatgac tccatcgaca gccccaaggc 780 catcacatct ctgaagtaca tgttgctgtg caaaatcatg ctcaacaccc cagaagatgt 840 ccaggctttg gtgagcggga agcttgcact tcggtatgca gggaggcaga cagaagcatt 900 aaaatgcgtg gctcaggcta gcaagaacag atcactggca gattttgaaa aggctctgac 960 agattaccgg gcagagctcc gggatgaccc aatcatcagc acacacttgg ccaagttgta 1020 tgataactta ctagaacaga atctgatccg agtcattgag cctttttcca gagtacagat 1080 tgaacacata tctagtctca tcaaactctc caaggccgac gtggaaagga aattatcaca 1140 gatgattctt gacaagaaat ttcatgggat tttggaccag ggggagggtg tcctgattat 1200 tttcgatgaa cccccagtag ataaaactta cgaagctgct ctggaaacaa ttcagaacat 1260 gagcaaagta gtggattccc tctacaacaa agccaagaaa ctgacataga gttggatctg 1320 tagcggtcct ttggagagtg tgtgtggcgg gagagtgaaa ccttggggga aaatgctagg 1380 agattctttt ttctttttgt tctacttttc gctcggaaag tttttaaatc ctcatttggt 1440 gcatctgtat 1450 <210> 3 <211> 1633 <212> DNA <213> Human <400> 3 ctcaagatga gtaaaaagcc cccaaatcgc cctggaatca cttttgagat tggtgctcgt 60 ttggaggcac tggactactt acaaaaatgg tatccatcac gaattgaaaa aattgactat 120 gaggagggca agatgttggt ccattttgag cgctggagtc atcgttatga tgagtggatt 180 tactgggata gcaatagatt gcgacccctt gagagaccag cactaagaaa agaagggcta 240 aaagatgagg aagatttctt tgattttaaa gctggagaag aagttctggc tcgttggaca 300 gactgtcgct attaccctgc caagattgaa gcaattaaca aagaaggaac atttacagtt 360 cagttttatg atggagtaat tcgttgttta aaaagaatgc acattaaagc catgcccgag 420 gatgctaagg ggcaggattg gatagcttta gtcaaagcag ctgctgcagc tgcagccaag 480 aacaaaacag ggagtaaacc tcgaaccagc gctaacagca ataaagataa ggataaagat 540 gagagaaagt ggtttaaagt accttcaaag aaggaggaaa cttcaacttg tatagccaca 600 ccagacgtag agaagaagga agatctgcct acatctagtg aaacatttgg acttcatgta 660 gagaacgttc caaagatggt ctttccacag ccagagagca cattatcaaa caagaggaaa 720 aataatcaag gcaactcgtt tcaggcaaag agagctcgac ttaacaagat tactggaaga 780 gaccagctgt gtattttata gctaatatag aatactggaa ggttgtaact ttattggttt 840 gttggcatcc aaagctgttg gggttgatgg tgctgaaaaa aaggaagact acaatgaaac 900 agctccaatg ctggagcagg cgatttcacc taaacctcaa agtcagaaaa aaaatgaagc 960 tgacattagc agttctgcca acactcagaa acctgcactg ttatcctcaa ctttgtcttc 1020 agggaaggct cgcagcaaga aatgcaaaca tgaatctgga gattcttctg ggtgtataaa 1080 accccctaaa tcaccacttt ccccagaatt aatacaagtc gaggatttga cgcttgtatc 1140 tcagctttct tcttcagtga taaataaaac tatgcctgat gttgcacatt tgccacttga 1200 gaagctggga ccctgtctcc ctcttgactt aagtcgtggt tcagaagtta cagcaccggt 1260 agcctcagat tcctcttacc gtaatgaatg tcccagggca gaaaaagagg atacacagat 1320 gcttccaaat ccttcttcca aagcaatagc tgatggaaga ggagctccag cagcagcagg 1380 aatatcgaaa acagaaaaaa aagtgaaatt ggaagacaaa agctcaacag catttggtat 1440 caggagttgg gatttctcag cactgctaat gaagatcccc tcttatagtc caataagctt 1500 atcaggactt ccagagtcat gacatgaaca gtttaattga acccatccac tctgggcagg 1560 taagagaaaa gaaaaagata aggaaagaag agagaagaga gacaaagatc actacagacc 1620 aaaacagaag aag 1633 <210> 4 <211> 2666 <212> DNA <213> Human <400> 4 ggcacgaggg tcacctggga agagtctgca gagcctttgc ccgccagcgc cttcgctctt 60 tggctccctg agttaatccg gttgtttgcg atcgccgcgg ccggggctgc gaaccgaagg 120 gctcgctccg cgccgcctgg gtctctacct catccgtagg tgtggccctg atggtgtggc 180 aggctctgga ctcctaaagc tctggagcga atttaagatt ttattcatgt gcatggcata 240 gaagatgaat tcttccactt ccaccatgag tgaagagcct gacgctctat cggtagttaa 300 ccagttacgg gatctagcag cagatccgtt aaacagaaga gccatcgtcc aggatcaggg 360 atgtctgcct ggccttattt tatttatgga ccatcccaac cctccagtcg tccactccgc 420 tttgcttgct cttcgatact tggcagaatg ccgtgcaaac agagaaaaga tgaaaggaga 480 actgggtatg atgttgagct tacaaaatgt tatacagaaa actacaactc caggagaaac 540 aaaacttctg gcctctgaaa tctatgacat tcttcagtcc tccaatatgg cagatggtga 600 tagttttaat gagatgaatt cacgtcgaag gaaagctcaa ttttttctgg gaactacaaa 660 caaacgtgcc aaaacagtgg ttttgcatat agatggcctt gatgatacgt ctcggagaaa 720 tctatgtgaa gaggctttgt taaaaattaa aggtgttatt agctttactt ttcaaatggc 780 tgttcaaagg tgtgtggtgc gaatccgttc agatttgaaa gctgaggctt tggcatcagc 840 aatagcatca accaaggtta tgaaagctca gcaagttgtg aaaagtgaaa gtggagaaga 900 gatgttggtc ccattccaag atactcctgt ggaagttgaa cagaacacag agctacctga 960 ctacctgcct gaggatgaga gtcccacaaa ggaacaggac aaagcggtgt cccgggtcgg 1020 ctcacaccca gaaggtggag ctagctggct tagcacagct gcaaactttt tatccagatc 1080 attttattgg tgacttcact tttgggctca aggactgtgt gaaccaacaa ggggccagtt 1140 ttccattgtt gtggtgaact gtcaagtgca atttgcaata agttatcatg aaaagttttt 1200 agattacacg atcgcatatg ctgcatttca cattttattg gacattttac cccactgagt 1260 ggtaaaaagg acagaggcta cagatggagt tgctttgttt atgaaagtat tttggtttgt 1320 tttctttcat ttaattgcct catatttaaa aaccatgggt ccactgttaa aaccacatgt 1380 gtatgtgcag ctttacattt tattttacgt gaagcatgtg attaggaaaa ctcattttct 1440 tttcaagcct caggacctac ctgaagagaa gttttcttgt agctcaagtt gtgcatgaat 1500 tactgaatat tttactgtgc ttttcttcat gaagggtaca tgctttgtac tcttcactga 1560 aagctgaaaa catttcttgt taccctcttt tgtgcctttt tattttgcca accgtgttta 1620 tagaaaggac attactaatg acattttgca gattaaaaac attcatttga acacagtagt 1680 cccctagaaa aacaactcta caaaaatttt gcagccttat tcattataat tttgataaaa 1740 ttaacacaaa atcagtcaag aaggaaacat gtatattagt gaagtgtttt tggagactgt 1800 ttgaatgtga ccaaatgtgg ttctagttga cttcttttca ctttggctta tatcaattct 1860 tgagagttaa tgtgatcatg atattgcaaa caactataaa tggtctctag gccttacttt 1920 gtgattatac gttatctccg gctagaaaaa aataatggta gtaaagaaac tgacaaactg 1980 aaaataagaa aacaaaaatc aaatgcctat aataccataa tgccagtttg gtatagagtc 2040 caactttaaa acatgaattg ctcgacagag ttctattcag taggtgtttc tttgtattgt 2100 cttttgtgaa tttattatga aaatgctgcg ttgtgttgaa tgaaaaagac ccaaattact 2160 gcttatgaag aaataaagcc agcattgatc acttaatcct gtttctcatg tccagccaga 2220 aaaaagaact tcagtgaagg taagataaat aaatacatac acatatgttt ttttggtaga 2280 taagtgctaa ttacatatat gtaatgcttt attaaatttc tgaaatattt ggtaactaaa 2340 attttctttt tggaaattaa taaatccaga tacatattaa tgttgatatg agtaaaaaca 2400 aataggaaga aattgaaatt tcttttcatc aacatgtaga gctgctattt tactatttgg 2460 agaatatgat gtgaaaattg gacctcaaag ggtttccttg tgttttcatt gtaaaatacc 2520 atcatcagtg agagtcttga gttcactaac attgtcacct tctggagaga gagttaatgg 2580 ggggcattga ggatgatatt tttttacatg tgtttggttt ctgattcaag tgacacgcac 2640 aaactgaaaa aaaaaaaaaa aaaaaa 2666 <210> 5 <211> 2445 <212> DNA <213> Human <400> 5 tcctgtgcgt ccccaggtca ccgctcgccc tagttcccag gctttggcct ccggtgggcg 60 agaatcgcgg agcctgcggg gctgggcgcc gaagagccgg gccggcaccc aagcgggcgc 120 ggggctgtgc gggccaggcg gaggctcaag cggggatccc cgagcacgac ccccggagcc 180 gacggcgctg gggcccaagg ggccggccgg gcggtgacga cggcggaggc gaaggggcgg 240 cgggacccgg gcccggcccg tgtgcgtcct cgacggcccg gccccggctc cgcaggacgg 300 tgagccccag ggagacggat ctgggctccg ggagggacgc cccgtctgga tttgtcccgt 360 aggcccggcc cgggcccctc tggagcagaa cggccttggt gaggtggaca ggaagggacc 420 tcgcgagcag acgcgcgccc gcgacagcaa tcccgccccg gcctgtcggg agcggtgggg 480 cagaggctgc ggagccccag gaggatctgc ctccgctttc acagtcctcc agatttttcc 540 aagagcagca gaaaatgaat aaatccctgg ggccagtgtc attcaaggac gtggctgtgg 600 acttcaccca ggaggaatgg cagcagctgg atcctgagca gaagataact tacagggatg 660 tgatgctgga gaactacagc aatctagttt ctgtggggta tcacattatc aaaccggatg 720 ttatcagcaa gttggagcaa ggagaagagc catggatagt agaaggagaa ttcctacttc 780 agagctatcc agatgaagtc tggcaaactg atgacctaat agagagaatc caggaagagg 840 aaaataaacc ttcaaggcaa actgtgttca ttgagaccct gattgaagag agaggtaatg 900 ttcctggtaa aacttttgat gtagaaacga accctgttcc ttcaagaaaa atagcctata 960 aaaatagcct ctgtgactca tgtgaaaagt gtttaacgtc tgtttcagaa tatattagta 1020 gtgatggaag ctatgcaaga atgaaagctg atgaatgtag tggatgtggg aaatcactcc 1080 tccatattaa gcttgagaaa actcatccag gagatcaagc ttatgaattt aatcaaaatg 1140 gggaacctta tactctaaat gaagaaagtc tttatcagaa aattcgtatt ttggagaaac 1200 cttttgaata tattgaatgc cagaaagcct tccaaaagga cactgttttt gttaatcaca 1260 tggaagaaaa gccctataag tggaatggat ctgaaatagc ctttctccag atgtcggacc 1320 tcactgtaca tcagacatct catatggaaa tgaagcccta tgaatgcagt gaatgtggga 1380 aatccttctg taaaaagtca aaatttatta tacatcagag gactcacaca ggagagaaac 1440 cttacgaatg taatcagtgt gggaaatcct tctgccagaa gggaaccctt actgtgcatc 1500 agagaacaca cacaggggag aagccctatg aatgtaatga atgtgggaag aacttttacc 1560 agaagttaca cctcattcag catcagagaa ctcactcagg agagaagccc tatgaatgta 1620 gttattgtgg aaaatccttt tgccagaaga cacacctcac acaacatcag agaacacatt 1680 caggagagag accttatgtt tgtcatgact gtgggaaaac cttctcgcag aagtcagcac 1740 ttaatgacca tcagaaaatt cacacaggtg tgaaactcta caagtgtagt gaatgtggga 1800 aatgcttctg ccgcaagtct actctcacga cccacctgag gacccacaca ggagagaaac 1860 cgtatgaatg taatgagtgt ggaaaattct tctctcggtt gtcatatctc actgtacatt 1920 atagaactca ttcaggagag aaaccctatg agtgtactga atgtggaaaa aaattctacc 1980 acaaatcagc attcaacagc catcagagaa ttcataggag aggcaatatg aatgtaatag 2040 atgtgggaag gcttctctga agtcagacct cattttatat cagagaaccc tttcagtata 2100 gtgaatcaga aactcctgcc tgaagtcaaa caccttgtac atcagagagt tcacacaggt 2160 tagtgtggac atccccttgt gtgttggact cataatctga agactcacag aatggaaacc 2220 atgattataa caagaccaca tggtataaca atactagact atagacaagt aaaaatttat 2280 aaatattaag aatgtatata catgtcacca tggattggaa ctgttttgca tatcagggaa 2340 atcatagcca aggggaaatc tatcagtata aggaatgtgg aagacataat cctttggaaa 2400 ctgttaatac taaaagatat gtttctgata caatagcaaa cttga 2445 <210> 6 <211> 701 <212> DNA <213> Human <400> 6 taacggtccc catcttcttg gatcgcttaa cagctggccg gcggttcaca aagtgagtct 60 gctgtgctgt gtgacctgtg cgcggtctgt ggccggacct aaagatagac cgcaatggct 120 gaaaatggtg ataatgaaaa gatggctgcc ctggaggcca aaaatctgtc atcaaattga 180 gtattatttg gcgacttcaa tttgccacgg gacaagtttc taaaggaaca gataaaactg 240 gatgaaggct gggtaccttt ggagataatg ataaaattca acaggttgaa ccgtctaaca 300 acagacttta atgtaattgt ggaagcattg agcaaatcca aggcagaact catggaaatc 360 agtgaagata aaactaaaat cagaaggtct ccaagcaaac ccctacctga agtgactgat 420 gagtataaaa atgatgtaaa aaacagatct gttatattaa aggcttccca actgatgcaa 480 ctcttgatga cataaaagaa tggttagaag ataaaggtca agtactaaat attcagatga 540 gaagaacatt gcataaagca tttaagggat caatttttgt agtgttgata gcattgaatc 600 tgtaagaaat ttgtagagac ccctggcaga aagtacaaga aacagacctt gctattactt 660 tcaaggacga ttactttgcc aaaaaaaatt gacgatgaaa a 701 <210> 7 <211> 3364 <212> DNA <213> Human <400> 7 gattgttgcc gtgcgctgga gccgagtttc gctctgctgc ccaggctgga gtacagtgat 60 gtgatctcct gacgtcaagt gatccattcg cctcggcctc ccaaagttct gggattacaa 120 gtaatacaaa atacagttaa taaaatgtca acctcctgga gtgatcggtt acagaatgca 180 gcagatatgc ctgctaacat ggataagcat gccctgaaaa agtatcgtcg agaagcctat 240 catcgggtgt ttgtgaaccg aagtttagca atggaaaaga taaagtgttt tggttttgat 300 atggattata cccttgctgt gtacaagtcc ccagagtatg agtcccttgg ttttgagctt 360 actgtggaga gattagtttc tattggctat ccccaggagt tgctcagctt tgcttatgat 420 tctacattcc ctaccagggg acttgtcttt gacacactgt atggaaatct tttgaaagtc 480 gatgcctatg gaaacctctt ggtctgtgca catggattta actttataag gggaccagaa 540 actagagaac agtatccaaa taaatttatc cagcgagatg atactgaaag attttacatt 600 ctgaacacac tattcaacct accagagacc tacctgttgg cctgcctagt agattttttt 660 actaattgtc ccagatatac cagttgtgaa acaggattta aagatgggga cctcttcatg 720 tcctaccgga gtatgttcca ggatgtaaga gatgctgttg actgggttca ttacaagggc 780 tcccttaagg aaaagacagt tgaaaatctt gagaagtatg tagtcaaaga tggaaaactg 840 cctttgcttc tgagccggat gaaggaagta gggaaagtat ttcttgctac caacagtgac 900 tataaatata cagataaaat tatgacttac ctgtttgact tcccacatgg ccccaagcct 960 gggagctccc atcgaccatg gcagtcctac tttgacttga tcttggtgga tgcacggaaa 1020 ccactctttt ttggagaagg cacagtactg cgtcaggtgg atactaaaac tggcaagctg 1080 aaaattggta cctacacagg gcccctacag catggtatcg tctactcagg aggttcttct 1140 gatacgatct gtgacctgtt gggagccaag ggaaaagaca ttttgtatat tggagatcac 1200 atttttgggg acattttaaa atcaaagaaa cggcaagggt ggcgaacttt tttggtgatt 1260 cctgaactcg cacaggagct acatgtctgg actgacaaga gttcactttt cgaagaactt 1320 cagagcttgg atattttctt ggctgaactc tacaagcatc ttgacagcag tagcaatgag 1380 cgtccagaca tcagttccat ccagagacgt attaagaaag taactcatga catggacatg 1440 tgctatggga tgatgggaag cctgtttcgc agtggctccc ggcagaccct ttttgccagt 1500 caagtgatgc gttatgctga cctctatgca gcatctttca tcaacctgct gtattaccct 1560 ttcagctacc tcttcagggc tgcccatgtc ttgatgcctc atgaatcaac ggtggagcac 1620 acacacgtag atatcaatga gatggagtct cctcttgcca cccggaaccg cacatcagtg 1680 gatttcaaag acactgacta caagcggcac cagctgacac ggtcaattag tgagattaaa 1740 cctcccaacc tcttcccact ggccccccag gaaattacac actgccatga cgaagatgat 1800 gatgaagagg aggaggagga ggaagaataa ggaggaaaac caaaacccca agcacccatt 1860 aaacaagtcc tggcaggact cacaggaaca aacgaggtcc ctgttagggt tctactcggg 1920 ggagggaggg ggctccatga aaggtacgtc tgaaaagttt ctgaagattt tattatcata 1980 gatacttgtt ttggttttgt gtatctgtac tctctgcaga tggtccaaaa ttgtaatgga 2040 gtctgtatta gaagaaaata agggtaaaat caggctgaac tgcatgtata tggctccact 2100 gtggcttgtg acacttttaa aatcatccgt atgtcagtgt atctggatac acgaggaaaa 2160 ggaaagagtc tcagagtgga acaaagagtg ggaagaggtg atctgtaatg ttacaaattg 2220 tgctattact ccaaggtcca acttttccag tgcattacat ggtattgtat atcagtggag 2280 aaatgtatta tttccatgat caaatgtagt ctctgttaag gtcaagtttt cttttataag 2340 cctttaattc atcctcagtg actctggcaa ggctgcttct ctatcactgg ctttgcacag 2400 aagtatgctc tacttgcgtt gctttagggc aggattctat tttgagggaa aagacagtat 2460 ccttattacc ttttgtttgt ttaatagcac aaatgcttat ttgttatcca aaaacaacct 2520 ccttcttatc tgtgataaat ctatagaaag aatttagctg caagtggaca aaggaacaag 2580 cccccagaaa agaaagggaa gaactgcctt cttatactac agaacatgca ttagtgtggg 2640 ctatatagct gtggctcatg ctacccaatt ccagatttct ttgtcctcta agagttgatt 2700 gctgtatatt aaaattgaac atcagaggat gggaagaggg ctctgtaagc cagaacctta 2760 ctaaagtaga gggcacaatc agtgtgaata aattcacttc agaatctcaa gtcaaggcca 2820 ggcacggcgg ctcacgcctg taatcccagc actttgggag gccgagacag gcggatcacc 2880 tgaggtcggg agttcgagac cagccttacc aacatggaga aaccccatct ctactaaaaa 2940 tacaaaatta cctgggcgtg gtggtgcatg cctgtaatcc catcatctac tcaggaggct 3000 gaggcaggag aattgcttga acccaggagg cggaggttgc agtgagccag gattgtgcca 3060 ttgcactcca gcctgggcaa caagaacaaa actccatctc aaaaaataaa aatcccaatc 3120 ccaagtcgaa atcacctctt gttttaaaca agaatgaatc attactgtgt atgttagggt 3180 attaaaactg tttcaccagt acagtgaaag ttgtttcaac attttaaaca aacagtggtt 3240 atagactctt tctttaacca ttgtatattt tcttccattc ttgtcattgg tcaatagggg 3300 agggtagatt agctgctcca gaattcaata aagtgtaata tttctaaaaa aaaaaaaaaa 3360 aaaa 3364 <210> 8 <211> 3825 <212> DNA <213> Human <400> 8 aagacaactt gagctgaaag cgaaaaacta tgctgaccag attagcagac ttgaagaaag 60 agaagcagaa ctgaagaagg aatataatgc attacatcaa agacacactg agatgatcca 120 taattatatg gaacatttag aaagaacaaa acttcatcag ctctcaggga gtgatcaact 180 agaatccaca gctcatagta gaattagaaa agaacgccct atatcattag gaattttccc 240 attacctgct ggagatggat tgcttacacc tgatgctcag aaaggaggag agacccctgg 300 atctgagcaa tggaaatttc aggaattaag tcaaccacgt tctcatacca gcctgaagga 360 tgagctttct gatgttagcc aaggcggatc taaagctacc actccagcat caacagctaa 420 ttcagatgtg gcaacaattc ctactgatac tcccttaaag gaagaaaacg aaggatttgt 480 gaaggttaca gatgcgccaa ataaatcaga gataagcaaa cacattgaag tacaggtagc 540 ccaggaaact agaaatgtat ctactggctc tgctgaaaat gaagaaaagt cagaagttca 600 agcaatcatc gaatctactc ctgagctgga tatggacaaa gatctcagtg gatataaagg 660 ttcaagcact cccaccaaag gcatagagaa caaagctttt gatcgcaata cagaatctct 720 ctttgaagaa ctgtcttcag ctggctcagg cctaatagga gatgtggatg aaggagcaga 780 tttactagga atgggtcggg aagttgagaa tcttatatta gaaaatacac aactgttgga 840 aaccaaaaat gctttgaaca tagtgaagaa tgatttgata gcaaaagtgg atgaactgac 900 ctgtgagaaa gatgtgctgc aaggggaatt ggaggctgtg aagcaagcca aactgaaact 960 agaggaaaag aacagagaat tggaggaaga gcttaggaaa gctcgggcag aagctgaaga 1020 tgcaaggcaa aaagcaaaag atgacgatga tagtgatatt cccacagccc agaggaaacg 1080 gtttactaga gtagaaatgg cccgtgttct catggagcga aaccagtata aagagagatt 1140 gatggagctt caggaagctg ttcgatggac agagatgatt cgggcatcac gagaaaatcc 1200 agccatgcag gaaaaaaaaa ggtcaagcat ttggcagttt ttcagccgac ttttcagctc 1260 ctcaagtaac acgactaaga agcctgaacc acctgttaat ctgaagtaca atgcacccac 1320 gtctcatgtt actccgtccg tcaagaaaag aagcagcacc ttatctcagc tccctgggga 1380 taagtccaaa gcctttgatt tccttagtga agaaactgaa gctagtttag cctcacgcag 1440 agaacaaaag agagagcagt atcgtcaggt aaaagcacat gttcagaagg aagacggtag 1500 agtgcaggct tttggctgga gtctgcctca gaagtacaaa caggtaacca atggtcaagg 1560 tgaaaataag atgaaaaatt tacctgtgcc tgtctatctc agacctctgg atgaaaaaga 1620 tacatcaatg aagctgtggt gtgctgttgg agtcaattta tctggtggga agaccagaga 1680 tggtggttct gttgttggag caagtgtatt ttacaaggat gttgctggtt tggatacaga 1740 aggcagtaaa cagcgaagtg cctctcagag tagtttagat aagttagatc aggaacttaa 1800 ggaacagcag aaggagttaa aaaatcaaga agaattatcc agtctagttt ggatctgtac 1860 cagcactcat tcggctacaa aagttcttat tattgatgct gttcaacctg gcaacatcct 1920 agacagtttc actgtttgca actctcatgt tctgtgcatt gcaagtgtgc caggtgcacg 1980 agaaacagac taccctgcag gagaagatct ttcagaatct ggtcaggtag acaaagcatc 2040 tttatgtgga agtatgacaa gcaacagctc agcagagaca gacagcctgt taggaggcat 2100 cacagtggtt ggttgttctg cagaaggtgt gacgggagct gccacttccc ctagtacaaa 2160 tggtgcttct ccagtgatgg ataaaccacc agaaatggaa gcagaaaata gtgaggttga 2220 tgaaaatgtt ccaacagcag aagaagcaac tgaagctaca gaagggaatg cggggtcagc 2280 tgaagacaca gtggacatct cccaaactgg cgtctacaca gagcatgtct ttacagatcc 2340 tttgggagtt cagatcccag aagacctctc cccagtgtat cagtcgagca atgactcaga 2400 tgcatataaa gatcaaatat cagtactgcc aaatgaacaa gacttggtga gagaagaagc 2460 ccagaaaatg agtagtcttt taccaactat gtggcttgga gctcaaaatg gctgtttgta 2520 tgtccattca tctgtagccc agtggaggaa atgtctccat tccattaaac ttaaagattc 2580 gattctcagt attgtacacg tgaagggaat cgtgttagta gccctggctg acggcaccct 2640 tgcaatcttt cacagaggag tggatgggca gtgggatttg tcaaactatc acctcttaga 2700 ccttggacgg cctcatcatt ccatccgttg catgactgtg gtacatgaca aagtctggtg 2760 tggctatagg aacaaaatct atgtggtgca gccaaaggcc atgaaaatag agaaatcttt 2820 tgatgcacat cccaggaagg agagccaagt gcgacagctt gcgtgggtgg gggatggcgt 2880 gtgggtctcc attcgcttgg attctacgct ccgtctctat catgcacaca cttatcaaca 2940 tctacaggat gtggacattg agccttatgt aagcaaaatg ttaggtactg gaaaactggg 3000 cttctctttt gtgagaatta cagctcttat ggtgtcttgt aatcgtttgt gggtggggac 3060 aggaaatggt gtcattatct ccatcccatt gacagaaaca aataaaacct caggtgtacc 3120 aggaaatcgt cctggaagtg taatccgtgt atatggtgat gaaaacagtg ataaagtgac 3180 tccagggaca tttataccct attgttcaat ggcacatgca cagctttgct tccatgggca 3240 ccgggatgct gtgaaattct ttgtggcagt cccaggtcaa gtcatcagcc cacaaagtag 3300 cagtagtggc acggatctga cgggtgacaa agcagggcca tctgcacagg agcctggtag 3360 tcagacgccc ttgaagtcta tgcttgtcat cagtggagga gagggctaca tcgacttccg 3420 aatgggtgat gaaggtggag aatcagaact tcttggagag gatcttccac ttgaaccttc 3480 tgtcaccaaa gcagaaagga gtcacttgat agtgtggcaa gtgatgtatg gcaatgagtg 3540 agcccatggg aaacaggtgg agatggggaa gccgtctctt ctgcatggtt tattttccct 3600 ctatcctttt atttaatgct cttttgtgag ataagtttca ccacataatg tgtgagcatt 3660 ttttcctgtt aactttatat tacaaaatcc gttctaccat aacaatacag aggaactagc 3720 tgtgttactg caccagtgtt ataggtaact tcagtatatt atgaacaaat caaagaatgt 3780 ttacttcctg caaactggtg aattatagaa agcaatccag atgtg 3825 <210> 9 <211> 471 <212> DNA <213> Human <220> <221> misc_feature <222> (468)..(468) <223> any kind of base <400> 9 tttggtttgt ttgtttttta aagacagggt cttgctctgt cacctaggct ggagtgcagt 60 ggcatgatct tggctcactg caacctccac ctcctggact caagcaatcc tcccacctca 120 gcctcccaag tagctgggac taaaagtgcg gacccggcta atttttgtat tttttgtaga 180 gatggggtct ccctatgttg cccaggctgg tctcgaatgc ccgggctcaa gtgatctgcc 240 cgccttggct tcccaaagtg ctgcgattac aggcatgagg cactgtgcct ggccttcgtg 300 gaaatcctaa aaagcaacac cacatagtgc tgggctgtat ccaggccagt gggcaccttc 360 cgtgctggta atgaacagcc acaaaacttc tggaaaacca catggaagtt tctattttat 420 gtgaaatgtc gaactcacac accacttgcc cagtggtcct gaggagtnca c 471 <210> 10 <211> 565 <212> DNA <213> Human <220> <221> misc_feature <222> (476)..(476) <223> any kind of base <220> <221> misc_feature <222> (482)..(482) <223> any kind of base <400> 10 ggcaccatac tgttttattt aaacctgcaa acaatataaa gaggtaagga cttctgacgc 60 caaaccatgc aagtaataac aaaggaacag agaaaaatat taataacaaa aagaaaatca 120 ttaaaaataa aaaaacaaag tacttcacat ttcacagcag tgctttggca gtactggcaa 180 gcatttctgg tcaactgctt ccaacagcag gaatatgaag aaacccccag atcttagcaa 240 aagtgtaaca acattttctc cctgacagct tacattccaa gtcattccat accataccgc 300 tccactccac agttttataa acctgatctt aagatgtaac taggtactat gtgtgctcac 360 aataaaaact aactaaaaac aaatcagagg gtagcagaca agtaaacaaa gtttccagta 420 aggcatcagg agatcactgc tggtgggccc ctcactttac cagcttaaag aagttntgat 480 tnttatttct cagcaaactc aatattcaga agctttacca gcagactcaa gtcaaaggtt 540 ttaaatacag tttacctcat ttttt 565 <210> 11 <211> 3615 <212> DNA <213> Human <400> 11 ggactgtgtg tgtctggctg tagcagacgc gaggcggcga cgaggcgccg gggacccgcg 60 cgaggggcgg ccgggaggcg gcggcggcgg ccgccagaag tagcagcagg accggcggcg 120 gcgacggcag ccctgaaatg cattttcctc tccagcggcc atgttaacca ggaaaccttc 180 ggccgccgct cccgccgcct acccgaccgg ccgaggtggg gacagcgccg ttcgtcagct 240 tcaggcttcc ccggggctcg gtgcagggcc cacccggagc ggagtgggga ctggcccgcc 300 ctcccccatc gccctgccgc ctctccgggc cagcaacgct gccgccgcag cccacacgat 360 tggcggcagt aagcacacaa tgaatgatca cctgcatgtc ggcagccacg ctcacggaca 420 gatccaggtt caacagttgt ttgaggataa cagtaacaag cggacagtgc tcacgacaca 480 accaaatggg cttacaacag tgggcaaaac gggcttgcca gtggtgccag agcggcagct 540 ggacagcatt catagacggc aggggagctc cacctctcta aagtccatgg aaggcatggg 600 gaaggtgaaa gccaccccca tgacacctga acaagcaatg aagcaataca tgcaaaaact 660 cacagccttc gaacaccatg agattttcag ctaccctgaa atatatttct tgggtctaaa 720 tgctaagaag cgccagggca tgacaggtgg gcccaacaat ggtggctatg atgatgacca 780 gggatcatat gtgcaggtgc cccacgatca cgtggcttac aggtatgagg tcctcaaggt 840 cattgggaag gggagctttg ggcaggtggt caaggcctac gatcacaaag tccaccagca 900 cgtggcccta aagatggtgc ggaatgagaa gcgcttccac cggcaagcag cggaggagat 960 ccgaatcctg gaacacctgc ggaagcagga caaggataac acaatgaatg tcatccatat 1020 gctggagaat ttcaccttcc gcaaccacat ctgcatgacg tttgagctgc tgagcatgaa 1080 cctctatgag ctcatcaaga agaataaatt ccagggcttc agtctgcctt tggttcgcaa 1140 gtttgcccac tcgattctgc agtgcttgga tgctttgcac aaaaacagaa taattcactg 1200 tgaccttaag cccgagaaca ttttgttaaa gcagcagggt agaagcggta ttaaagtaat 1260 tgattttggc tccagttgtt acgagcatca gcgtgtctac acgtacatcc agtcgcgttt 1320 ttaccgggct ccagaagtga tccttggggc caggtatggc atgcccattg atatgtggag 1380 cctgggctgc attttagcag agctcctgac gggttacccc ctcttgcctg gggaagatga 1440 aggggaccag ctggcctgta tgattgaact gttgggcatg ccctcacaga aactgctgga 1500 tgcatccaaa cgagccaaaa attttgtgag ctccaagggt tatccccgtt actgcactgt 1560 cacgactctc tcagatggct ctgtggtcct aaacggaggc cgttcccgga gggggaaact 1620 gaggggccca ccggagagca gagagtgggg gaacgcgctg aaggggtgtg atgatcccct 1680 tttccttgac ttcttaaaac agtgtttaga gtgggatcct gcagtgcgca tgaccccagg 1740 ccaggctttg cggcacccct ggctgaggag gcggttgcca aagcctccca ccggggagaa 1800 aacgtcagtg aaaaggataa ctgagagcac cggtgctatc acatctatat ccaagttacc 1860 tccaccttct agctcagctt ccaaactgag gactaatttg gcgcagatga cagatgccaa 1920 tgggaatatt cagcagagga cagtgttgcc aaaacttgtt agctgagctc acgtcccctg 1980 atgctggtaa cctgaaagat acgacattgc tgagccttac tgggttgaaa aggagtagct 2040 cagacctgtt tttatttgct caataactct actcatttgt atcttttcag cacttaattt 2100 taatgtaaga aagttgttca ttttgttttt ataaaataca tgaggacaat gctttaagtt 2160 tttatacttt cagaaacttt ttgtgttcta aaagtacaat gagccttact gtatttagtg 2220 tggcagaata ataacatcag tggcaggcca ctgattactt catgactgcc acgcatttac 2280 agattggtgt caaagacatt cactatgttt ttatggttca tgttatatcc tccccagggt 2340 gacagcccct taaggccctc cttttccctc catgctccag gtccatgcac aggtgtagca 2400 tgtcctgctt ccgtttttca taaattaatc tgggtgttgg gggtagtggg aggagaacgg 2460 tcagaatcaa agtgacattc taagaaaaac tgtaccttag agattttcct ctagtgctca 2520 aacaaataca aaataagatc cccaaggttt aaactgccca gttagcattc tgacattcta 2580 aaagccggca aagcagcttt tagtggataa atgggaatgg aaacgtgtgt gttcctccaa 2640 attttctagt atgatcggtg agctgttttg taaagaagcc tcatattaca gagttgcttt 2700 tgcacctaaa tttagaattg tattccatga actgttcctc ccttttctct gcttttctcc 2760 tctctgttcc tcttttaata ccacacgtct gttgcttgca tttagtttgt cttcttcctt 2820 cagctgtgta tcccagactg ttaatacaga aaagagacat ttcagctgtg attatgacca 2880 ttgtttcata ttccaattaa aaaaagaaca gcagcctagc tacttaaggt ggggatttca 2940 tagttccaaa gaagatttag cagattagag tgagttcaca cttttcaggt gccactgtaa 3000 ggttctctca gcctgggaaa ctatcaactc tttctttaaa aagaaagagg gttgaaaatc 3060 ctctggacga acagaagtca ctttggctgt tcagtaaggc caatgttaac aacacgttta 3120 gaggaggaaa agttcaacct caagttaaat ggtttgactt attcttcgta tcattagaag 3180 aaccccagag atagcattcc tctattttat tttactttct tttggattgc actgattgtt 3240 tttgtgggaa tgacacttta tctggcaaag taactgagag tttggtaaaa gaatattttc 3300 ttctctgaat aataattatt ttcacagtga aaatttcagt attttatcac taatgtatga 3360 gcaatgatct atatcaattt caaggcacgt gaaaaaaatt ttttagtatg tgcaatttaa 3420 tatagaaaga tttctgcctg tttggacaat aggttttggg tagtacagat taggataagt 3480 aagcttatat atgcacagag attattgtat tacctgtaaa ttgatttaca agtacttaaa 3540 agcgtggtcc ccagtgaggc caagaaagtt tccggttaag ttctttaata ataatcctac 3600 agtttatctt aagaa 3615 <210> 12 <211> 4908 <212> DNA <213> Human <400> 12 acctgcgtgc agtcggtcct ccaggccacg cagcgcccga gagtaccagg gagactccgg 60 cccctgtcgg cgccaagccc ctccgcccct cacagcgccc aggtccgcgg ccgggccttg 120 attttttggc ggggaccgtc atggcgtcgc agccaaattc gtctgcgaag aagaaagagg 180 agaaggggaa gaacatccag gtggtggtga gatgcagacc atttaatttg gcagagcgga 240 aagctagcgc ccattcaata gtagaatgtg atcctgtacg aaaagaagtt agtgtacgaa 300 ctggaggatt ggctgacaag agctcaagga aaacatacac ttttgatatg gtgtttggag 360 catctactaa acagattgat gtttaccgaa gtgttgtttg tccaattctg gatgaagtta 420 ttatgggcta taattgcact atctttgcgt atggccaaac tggcactgga aaaactttta 480 caatggaagg tgaaaggtca cctaatgaag agtatacctg ggaagaggat cccttggctg 540 gtataattcc acgtaccctt catcaaattt ttgagaaact tactgataat ggtactgaat 600 tttcagtcaa agtgtctctg ttggagatct ataatgaaga gctttttgat cttcttaatc 660 catcatctga tgtttctgag agactacaga tgtttgatga tccccgtaac aagagaggag 720 tgataattaa aggtttagaa gaaattacag tacacaacaa ggatgaagtc tatcaaattt 780 tagaaaaggg ggcagcaaaa aggacaactg cagctactct gatgaatgca tactctagtc 840 gttcccactc agttttctct gttacaatac atatgaaaga aactacgatt gatggagaag 900 agcttgttaa aatcggaaag ttgaacttgg ttgatcttgc aggaagtgaa aacattggcc 960 gttctggagc tgttgataag agagctcggg aagctggaaa tataaatcaa tccctgttga 1020 ctttgggaag ggtcattact gcccttgtag aaagaacacc tcatgttcct tatcgagaat 1080 ctaaactaac tagaatcctc caggattctc ttggagggcg tacaagaaca tctataattg 1140 caacaatttc tcctgcatct ctcaatcttg aggaaactct gagtacattg gaatatgctc 1200 atagagcaaa gaacatattg aataagcctg aagtgaatca gaaactcacc aaaaaagctc 1260 ttattaagga gtatacggag gagatagaac gtttaaaacg agatcttgct gcagcccgtg 1320 agaaaaatgg agtgtatatt tctgaagaaa attttagagt catgagtgga aaattaactg 1380 ttcaagaaga gcagattgta gaattgattg aaaaaattgg tgctgttgag gaggagctga 1440 atagggttac agagttgttt atggataata aaaatgaact tgaccagtgt aaatctgacc 1500 tgcaaaataa aacacaagaa cttgaaacca ctcaaaaaca tttgcaagaa actaaattac 1560 aacttgttaa agaagaatat atcacatcag ctttggaaag tactgaggag aaacttcatg 1620 atgctgccag caagctgctt aacacagttg aagaaactac aaaagatgta tctggtctcc 1680 attccaaact ggatcgtaag aaggcagttg accaacacaa tgcagaagct caggatattt 1740 ttggcaaaaa cctgaatagt ctgtttaata atatggaaga attaattaag gatggcagct 1800 caaagcaaaa ggccatgcta gaagtacata agaccttatt tggtaatctg ctgtcttcca 1860 gtgtctctgc attagatacc attactacag tagcacttgg atctctcaca tctattccag 1920 aaaatgtgtc tactcatgtt tctcagattt ttaatatgat actaaaagaa caatcattag 1980 cagcagaaag taaaactgta ctacaggaat tgattaatgt actcaagact gatcttctaa 2040 gttcactgga aatgatttta tccccaactg tggtgtctat actgaaaatc aatagtcaac 2100 taaagcatat tttcaagact tcattgacag tggccgataa gatagaagat caaaaaaagg 2160 aactagatgg ctttctcagt atactgtgta acaatctaca tgaactacaa gaaaatacca 2220 tttgttcctt ggttgagtca caaaagcaat gtggaaacct aactgaagac ctgaagacaa 2280 taaagcagac ccattcccag gaactttgca agttaatgaa tctttggaca gagagattct 2340 gtgctttgga ggaaaagtgt gaaaatatac agaaaccact tagtagtgtc caggaaaata 2400 tacagcagaa atctaaggat atagtcaaca aaatgacttt tcacagtcaa aaattttgtg 2460 ctgattctga tggcttctca caggaactca gaaattttaa ccaagaaggt acaaaattgg 2520 ttgaagaatc tgtgaaacac tctgataaac tcaatggcaa cctggaaaaa atatctcaag 2580 agactgaaca gagatgtgaa tctctgaaca caagaacagt ttatttttct gaacagtggg 2640 tatcttcctt aaatgaaagg gaacaggaac ttcacaactt attggaggtt gtaagccaat 2700 gttgtgaggc ttcaagttca gacatcactg agaaatcaga tggacgtaag gcagctcatg 2760 agaaacagca taacattttt cttgatcaga tgactattga tgaagataaa ttgatagcac 2820 aaaatctaga acttaatgaa accataaaaa ttggtttgac taagcttaat tgctttctgg 2880 aacaggatct gaaactggat atcccaacag gtacgacacc acagaggaaa agttatttat 2940 acccatcaac actggtaaga actgaaccac gtgaacatct ccttgatcag ctgaaaagga 3000 aacagcctga gctgttaatg atgctaaact gttcagaaaa caacaaagaa gagacaattc 3060 cggatgtgga tgtagaagag gcagttctgg ggcagtatac tgaagaacct ctaagtcaag 3120 agccatctgt agatgctggt gtggattgtt catcaattgg cggggttcca tttttccagc 3180 ataaaaaatc acatggaaaa gacaaagaaa acagaggcat taacacactg gagaggtcta 3240 aagtggaaga aactacagag cacttggtta caaagagcag attacctctg cgagcccaga 3300 tcaaccttta attcacttgg gggttggcaa ttttattttt aaagaaaact taaaaataaa 3360 acctgaaacc ccagaacttg agccttgtgt atagatttta aaagaatata tatatcagcc 3420 gggcgcggtg gctcatgcct gtaatcccag cactttggga ggctgaggcg ggtggattgc 3480 ttgagcccag gagtttgaga ccagcctggc caacgtggca aaacctcgtc tctgttaaaa 3540 attagccggg cgtggtggca cactcctgta atcccagcta ctggggaggc tgaggcacga 3600 gaatcacttg aacccaggaa gcggggttgc agtgagccaa aggtacacca ctacactcca 3660 gcctgggcaa cagagcaaga ctcggtctca aaaacaaaat ttaaaaaaga tataaggcag 3720 tactgtaaat tcagttgaat tttgatatct acccattttt ctgtcatccc tatagttcac 3780 tttgtattaa attgggtttc atttgggatt tgcaatgtaa atacgtattt ctagttttca 3840 tataaagtag ttcttttata acaaatgaaa agtatttttc ttgtatatta ttaagtaatg 3900 aatatataag aactgtactc ttctcagctt gagcttaaca taggtaaata tcaccaacat 3960 ctgtccttag aaaggaccat ctcatgtttt ttttcttgct atgacttgtg tattttcttg 4020 catcctccct agacttccct atttcgcttt ctcctcggct cactttctcc ctttttattt 4080 ttcaccaaac catttgtaga gctacaaaac ctatcctttc ttattttcag tagtcagaat 4140 tttatctaga aatcttttaa caccttttta gtggttattt ctaaaatcac tgtcaacaat 4200 aaatctaacc ctagttgtat ccctccttta agtatttaaa acttgttgcc ccaaatgtga 4260 aagcatttaa ttcctttaag aggcctaact cattcaccct gacagagttc acaaaaagcc 4320 cactttagag tatacattgc tattatggga gaccacccag acatctgact aatggctctg 4380 tgccacactc caagacctgt gccttttaga gaagctcaca atgatttaag gactgtttga 4440 aacttccaat tatgtctata atttatattc ttttgtttac atgatgaaac tttttgttgt 4500 tgcttgtttg tatataatac aatgtgtaca tgtatctttt tctcgattca aatcttaacc 4560 cttaggactc tggtattttt gatctggcaa ccatatttct ggaagttgag atgtttcagc 4620 ttgaagaacc aaaacagaag gaatatgtac aaagaataaa ttttctgctc acgatgagtt 4680 tagtgtgtaa agtttagaga catctgactt tgatagctaa attaaaccaa accctattga 4740 agaattgaat atatgctact tcaagaaact aaattgatct cgtagaatta tcttaataaa 4800 ataatggcta taatttctct gcaaaatcag atgtcagcat aagcgatgga taatacctaa 4860 taaactgccc tcagtaaatc catggttaat aaatgtggtt tctacatt 4908 <210> 13 <211> 3302 <212> DNA <213> Human <400> 13 ggcacgaggc ggcagtctct tcgcggcgtc caccacttag acgcaagttg ctgaagccgg 60 ccggggagaa ggtgttgttg ccggagctga gaccgggcgg ccacagtccg cagggatgaa 120 cctcgagttg ctggagtcct ttgggcagaa ctatccagag gaagctgatg gaactttgga 180 ttgtatcagc atggctttga cttgcacctt taacaggtgg ggcacactgc ttgcagttgg 240 ctgtaatgat ggccgaattg tcatctggga tttcttgaca agaggcattg ctaaaataat 300 tagtgcacac atccatccag tgtgttcttt atgctggagc cgagatggtc ataaactcgt 360 gagtgcttcc actgataaca tagtgtcaca gtgggatgtt ctttcaggcg actgtgacca 420 gaggtttcga ttcccttcac ccatcttaaa agtccaatat catccacgag atcagaacaa 480 ggttctcgtg tgtcccatga aatctgctcc tgtcatgttg accctttcag attccaaaca 540 tgttgttctg ccggtggacg atgactccga tttgaacgtt gtggcatctt ttgataggcg 600 aggggaatat atttatacgg gaaacgcaaa aggcaagatt ttggtcctaa aaacagattc 660 tcaggatctt gttgcttcct tcagagtgac aactggaaca agcaatacca cagccattaa 720 gtcaattgag tttgcccgga aggggagttg ctttttaatt aacacggcag atcgaataat 780 cagagtttat gatggcagag aaatcttaac atgtggaaga gatggagagc ctgaacctat 840 gcaggaattg caggatttgg tgaataggac cccatggaag aaatgttgtt tctctgggga 900 tggggaatac atcgtggcag gttctgcccg gcagcatgcc ctgtacatct gggagaagag 960 cattggcaac ctggtgaaga ttctccatgg gacgagagga gaactcctct tggatgtagc 1020 ttggcatcct gttcgaccca tcatagcatc catttccagt ggagtggtat ctatctgggc 1080 acagaatcaa gtagaaaact ggagtgcatt tgcaccagac ttcaaagaat tggatgaaaa 1140 tgtagaatac gaagaaaggg aatcagggtt tgatattgaa gatgaagata agagtgagcc 1200 tgagcagaca ggggctgatg ctgcagaaga tgaggaagtg gatgtcacca gcgtggaccc 1260 tattgctgcc ttctgtagca gtgatgaaga gctggaagat tcaaaggctc tattgtattt 1320 acccattgcc cctgaggtag aagacccaga agaaaatcct tacggccccc caccggatgc 1380 agtccaaacc tccttgatgg atgaaggggc tagttcagag aagaagaggc agtcctcagc 1440 agatgggtcc cagccaccta agaagaaacc caaaacaacc aatatagaac ttcaaggagt 1500 accaaatgat gaagtccatc cactactggg tgtgaagggg gatggcaaat ccaagaagaa 1560 gcaagcaggc cggcctaaag gatcaaaagg taaagagaaa gattctccat ttaaaccgaa 1620 actctacaaa ggggacagag gtttacctct ggaaggatca gcgaagggta aagtgcaggc 1680 ggaactcagc cagcccttga cagcaggagg agcaatctca gaactgttat gaagaccttc 1740 gaagttcttc attctttctc actttgccat catgtggcct ctggacactg tggtcagtca 1800 tttgaaaatt gactttaatt taaaacaaag gcctgtgctc cacccaggag gtgggaggtg 1860 aattttatgt ttaaatgaag aagtgaatta tggaagaagg tatacgacct tcccttcctt 1920 ttcaagcata agtccaaata gactctcagg aatgaagatt tgtgaagaca tcagatagga 1980 attttggact catttaaact ttgatgctta gttatgttgc tggagaaaag atacttatgt 2040 tttgctcatc taacttcatt gtacccagcg tcattttgac atgtcatttc ctatctccca 2100 tttgccttcg gtcctcaatg catgtctttg agtgacttct tatctgaaat tttgctactg 2160 gtatcctagg aaagcttttg ttggatactc tcattttaaa cttctcctct ccccagatac 2220 ctcctatatt tccatattgt gtgcaaagga tgggcagaaa agaaagtgct tgaaagattt 2280 caaattttca gaaagggaac aacgaaggcc ctctcttcct ctcataccac gttttgctca 2340 agaagctggg ctgtaacaat tcagggtttt cccttgtttt cctctcattg catgtttccc 2400 tccaatattg gttcattgtc atcaatcatg gtttttgaag atagctagtt ttatccatct 2460 ccagcaaaga atcatcaata gtttatattg ctttacctgt gctggcttcc agagatggaa 2520 acaaacccag gtgtctctca acaagctact tttttactgg ggtgggggaa tctatgcaag 2580 gagtaaagta aaaccatcca gaatcaaagc agcaaccaca tagttcaaat caaagatcaa 2640 ggtgaatttt ttgtatcact gcctgtggaa atctatcctc atcagtcatt gcatttttcc 2700 ctgcctatac ctgtgctcct ttttcttact gtgttttcag tcacttcctt tctgtgaaag 2760 gttgcttagc tttttttttg acatttgttg ttctttatat aaaaataaca gattggatag 2820 atgtgtacat ttggtgtttg aaattctctg aaaatcccat taggaaacca ggtgtgaaaa 2880 gggctcagta gcttctctga gtggcgtttt tagctgactg gaagtgctta atctggatcg 2940 tctttttttt tttttttttt ttcaatattt taaaaggaga atttaaatac tgtgcttact 3000 gtgaaatata tcagttggtg agccgggcgt ggtgggtcac gcctgtaatc ccagcacttt 3060 gggaggccaa ggcgggtgga tcacccgagg tcaggagttc aagaccagcc tggccaacgt 3120 ggtgaaagcc tgtatctatt aaaagacaaa aattagctgg gcgtggtggt acatgcctgt 3180 aatcccagct acactggagg ctgagtcagg agaatcactt gaacgtggga ggcagaggtt 3240 gcagtgagtg gagatcgcac cactgccctc cagcctaggt gacagaatga gactctatct 3300 ca 3302 <210> 14 <211> 1999 <212> DNA <213> Human <400> 14 acgcgctctt agaccatggc gacccaggcg aagcgtccac gggtggcggg gcccgtggac 60 ggcggcgacc tggatcctgt ggcctgcttc ctgagctggt gccggcgggt ggggctggag 120 ctgagtccca aggtggcggt cagccggcag ggcacggtgg ccggctacgg catggtggcc 180 cgggagagcg tgcaggccgg agagctgctg ttcgtggtgc cgcgggccgc gctcctgtcg 240 cagcacacct gctccatcgg cggcctgctg gagcgagagc gagttgcgct gcagggccag 300 tcgggctggg tgccactgct gctggcgctg ctccacgagc tgcaggcccc ggcctcacgc 360 tggaggccct actttgcgct ctggcccgag ctgggccgct tggagcaccc gatgttctgg 420 ccagaggagg agcgccggtg cctgctccag ggcacaggcg tacctgaggc cgtggagaag 480 gatttggcca acatccgcag cgagtaccag tccatcgtgc tgcccttcat ggaagcccac 540 cccgatctct tcagcctcag ggttcgctcc ctagaactct accaccagct ggtggccctt 600 gtgatggcct atagctttca ggtaccactg gaggaagaag aggatgaaaa ggagcccaac 660 tcccccgtga tggtgcctgc tgcagacata ctaaaccact tagccaatca caacgccaat 720 ctagaatact ctgcgaattg tcttcggatg gtagccactc agcccattcc taaaggccat 780 gagattttca acacttatgg gcaaatggct aactggcaac tgattcatat gtacggtttt 840 gttgaaccat atcctgacaa cacagatgac acagctgaca ttcagatggt gacagttcgt 900 gaggcagcat tacagggaac aaaaactgaa gctgaaaggc acctagtgta cgagcgctgg 960 gatttcctat gcaaactgga gatggtaggg gaagagggag cctttgtgat agggagggag 1020 gaggtgctga ctgaagagga gctgaccacc acactaaagg tactgtgcat gcctgctgag 1080 gagttcagag agcttaaaga ccaggatgga gggggagatg ataaaaggga agagggcagc 1140 ctgacgatca caaatattcc caagctcaaa gcatcgtgga gacagctgct tcaaaacagt 1200 gttctactga ctttgcagac ctatgccaca gacttaaaaa ctgaccaagg tttactcagt 1260 aataaggaag tctatgcgaa actcagctgg agggaacagc aagccttaca ggttcgctat 1320 ggtcagaaga tgatcttaca tcagttgttg gaactgacaa gttagcagtt tccctgttcc 1380 ctgaaggaac agcaataaga actttattct aagctaatac tcattgatgt ttgaaaaaga 1440 ggaaaatttg gatctttctt ttgcttacta aacaccaaga ggaaaagtag caaagttggt 1500 gtgctaggat taactcaggt aagggtgatg tgttttagga ttgagaacag cagacttggg 1560 aatcactgct aattgttact taaagcatgt tacagctgtt ttgttctcag ttttaaccaa 1620 agccagtgga catacggtag taataactaa gtcttgttgt gtttcagcat ttaataatag 1680 actttggagg tagacccctg gtttaaatct aagtctagtt tgaggaagtc acttaacctt 1740 tattgaaaag actctggatt taataagctg tgtaactggt actcgatagt tacccaaagt 1800 tcagtctaga tggcacaaac cacctctcag ggaataaacc ctaagacatc actcaaggag 1860 gacttcaatt atttaatttt gaactgtttt gtcctctctg gccataaaac ttgacagtca 1920 tgaaaggtaa ggcaaatttt aagtgggtta agtttttaaa tacgtatcta ctcattttct 1980 ttaaaaaaaa aaaaaaaaa 1999 <210> 15 <211> 1503 <212> DNA <213> Human <400> 15 ggggctccac tttctttccc tctccgtttt ggtgggctgg ttggagatga aatccactga 60 ggagggaagt ccagcaccct gtgtgccagt cctgaactgg cccatctgta gaccccctga 120 aaatcatatg ggcttggatt tggatattct caacagaaag ggttaaaggc tgatggtacc 180 taaagcctgg tacttgaatt ttgatcaaga taagctgcct taagttctct tcattacaca 240 aatgatccta gataattgat agatcctgtg gttcaactgg atttctagat agaagctgga 300 ttcatgtgat gccagaggag taaaatttca agagactgaa accagatctg agtttcgctg 360 ttccagtctg gacctctttg gagctgtaaa tcctggatat actgtagatg agtactgcgt 420 ttttctttta tggactctct tcagcttctg gagacctcac tatcctatta tgtctttgtg 480 tgaagacatg ctgctttgta attatcgaaa gtgtcgcatc aaactctctg gctatgcatg 540 ggtcactgcc tgctctcaca tcttctgtga tcagcatggc agtggtgagt ttagtcgctc 600 accagctatc tgtcctgcct gcaacagtac cctttctgga aagctagata ttgtccgcac 660 agaactcagt ccatcagagg aatataaagc tatggtattg gcaggactgc gaccagagat 720 cgtgttggac attagctccc gagcgctggc cttctggaca tatcaggtac atcaggaacg 780 tctctatcaa gaatacaatt tcagcaaggc tgagggccat ctgaaacaga tggagaagat 840 atatactcag caaatacaaa gcaaggatgt agaattgacc tctatgaaag gggaggttac 900 ctccatgaag aaagtactag aagaatacaa gaaaaagttc agtgacatct ctgagaaact 960 tatggagcgc aatcgtcagt atcaaaagct ccaaggcctc tatgatagcc ttaggctacg 1020 aaacatcact attgctaacc atgaaggcac ccttgaacca tccatgattg cacagtctgg 1080 tgttcttggc ttcccattag gtaacaactc caagtttcct ttggataata cacctgttcg 1140 aaatcggggc gatggagatg gagattttca gttcagacca ttttttgcgg gttctcccac 1200 agcacctgaa cccagcaaca gcttttttag ttttgtctct ccaagtcgtg aattagagca 1260 gcagcaagtt tctagcaggg ccttcaaagt aaaaagaatt tgagccacgc atagtgtcac 1320 gcacctgtga tcccagctac ttaggaggtt gaggctggga ggatcacttg agcccaggag 1380 tctgaggctt tagtgatcta agatcatgcc actgcactcc agcctgggca acagagtgag 1440 accctgtttc taaaaaaaaa taaagataat ttagctaact tcaaaaaaaa aaaaaaaaaa 1500 aac 1503 <210> 16 <211> 5776 <212> DNA <213> Human <400> 16 gctcacccag gaaaaatatg caatcgtccc attgatatac aggccactac aatggatgga 60 gttaacctca gcaccgaggt tgtctacaaa aaaggccagg attataggtt tgcttgctac 120 gaccggggca gagcctgccg gagctaccgt gtacggttcc tctgtgggaa gcctgtgagg 180 cccaaactca cagtcaccat tgacaccaat gtgaacagca ccattctgaa cttggaggat 240 aatgtacagt catggaaacc tggagatacc ctggtcattg ccagtactga ttactccatg 300 taccaggcag aagagttcca ggtgcttccc tgcagatcct gcgcccccaa ccaggtcaaa 360 gtggcaggga aaccaatgta cctgcacatc ggggaggaga tagacggcgt ggacatgcgg 420 gcggaggttg ggcttctgag ccggaacatc atagtgatgg gggagatgga ggacaaatgc 480 tacccctaca gaaaccacat ctgcaatttc tttgacttcg atacctttgg gggccacatc 540 aagtttgctc tgggatttaa ggcagcacac ttggagggca cggagctgaa gcatatggga 600 cagcagctgg tgggtcagta cccgattcac ttccacctgg ccggtgatgt agacgaaagg 660 ggaggttatg acccacccac atacatcagg gacctctcca tccatcatac attctctcgc 720 tgcgtcacag tccatggctc caatggcttg ttgatcaagg acgttgtggg ctataactct 780 ttgggccact gcttcttcac ggaagatggg ccggaggaac gcaacacttt tgaccactgt 840 cttggcctcc ttgtcaagtc tggaaccctc ctcccctcgg accgtgacag caagatgtgc 900 aagatgatca cagaggactc ctacccaggg tacatcccca agcccaggca agactgcaat 960 gctgtgtcca ccttctggat ggccaatccc aacaacaacc tcatcaactg tgccgctgca 1020 ggatctgagg aaactggatt ttggtttatt tttcaccacg taccaacggg cccctccgtg 1080 ggaatgtact ccccaggtta ttcagagcac attccactgg gaaaattcta taacaaccga 1140 gcacattcca actaccgggc tggcatgatc atagacaacg gagtcaaaac caccgaggcc 1200 tctgccaagg acaagcggcc gttcctctca atcatctctg ccagatacag ccctcaccag 1260 gacgccgacc cgctgaagcc ccgggagccg gccatcatca gacacttcat tgcctacaag 1320 aaccaggacc acggggcctg gctgcgcggc ggggatgtgt ggctggacag ctgccggttt 1380 gctgacaatg gcattggcct gaccctggcc agtggtggaa ccttcccgta tgacgacggc 1440 tccaagcaag agataaagaa cagcttgttt gttggcgaga gtggcaacgt ggggacggaa 1500 atgatggaca ataggatctg gggccctggc ggcttggacc atagcggaag gaccctccct 1560 ataggccaga attttccaat tagaggaatt cagttatatg atggccccat caacatccaa 1620 aactgcactt tccgaaagtt tgtggccctg gagggccggc acaccagcgc cctggccttc 1680 cgcctgaata atgcctggca gagctgcccc cataacaacg tgaccggcat tgcctttgag 1740 gacgttccga ttacttccag agtgttcttc ggagagcctg ggccctggtt caaccagctg 1800 gacatggatg gggataagac atctgtgttc catgacgtcg acggctccgt gtccgagtac 1860 cctggctcct acctcacgaa gaatgacaac tggctggtcc ggcacccaga ctgcatcaat 1920 gttcccgact ggagaggggc catttgcagt gggtgctatg cacagatgta cattcaagcc 1980 tacaagacca gtaacctgcg aatgaagatc atcaagaatg acttccccag ccaccctctt 2040 tacctggagg gggcgctcac caggagcacc cattaccagc aataccaacc ggttgtcacc 2100 ctgcagaagg gctacaccat ccactgggac cagacggccc ccgccgaact cgccatctgg 2160 ctcatcaact tcaacaaggg cgactggatc cgagtggggc tctgctaccc gcgaggcacc 2220 acattctcca tcctctcgga tgttcacaat cgcctgctga agcaaacgtc caagacgggc 2280 gtcttcgtga ggaccttgca gatggacaaa gtggagcaga gctaccctgg caggagccac 2340 tactactggg acgaggactc agggctgttg ttcctgaagc tgaaagctca gaacgagaga 2400 gagaagtttg ctttctgctc catgaaaggc tgtgagagga taaagattaa agctctgatt 2460 ccaaagaacg caggcgtcag tgactgcaca gccacagctt accccaagtt caccgagagg 2520 gctgtcgtag acgtgccgat gcccaagaag ctctttggtt ctcagctgaa aacaaaggac 2580 catttcttgg aggtgaagat ggagagttcc aagcagcact tcttccacct ctggaacgac 2640 ttcgcttaca ttgaagtgga tgggaagaag taccccagtt cggaggatgg catccaggtg 2700 gtggtgattg acgggaacca agggcgcgtg gtgagccaca cgagcttcag gaactccatt 2760 ctgcaaggca taccatggca gcttttcaac tatgtggcga ccatccctga caattccata 2820 gtgcttatgg catcaaaggg aagatacgtc tccagaggcc catggaccag agtgctggaa 2880 aagcttgggg cagacagggg tctcaagttg aaagagcaaa tggcattcgt tggcttcaaa 2940 ggcagcttcc ggcccatctg ggtgacactg gacactgagg atcacaaagc caaaatcttc 3000 caagttgtgc ccatccctgt ggtgaagaag aagaagttgt gaggacagct gccgcccggt 3060 gccacctcgt ggtagactat gacggtgact cttggcagca gaccagtggg ggatggctgg 3120 gtcccccagc ccctgccagc agctgcctgg gaaggccgtg tttcagccct gatgggccaa 3180 gggaaggcta tcagagaccc tggtgctgcc acctgcccct actcaagtgt ctacctggag 3240 cccctggggc ggtgctggcc aatgctggaa acattcactt tcctgcagcc tcttgggtgc 3300 ttctctccta tctgtgcctc ttcagtgggg gtttggggac catatcagga gacctgggtt 3360 gtgctgacag caaagatcca ctctggcagg agccctgacc cagctaggag gtagtctgga 3420 gggctggtca ttcacagatc cccatggtct tcagcagaca agtgagggtg gtaaatgtag 3480 gagaaagagc cttggcctta aggaaatctt tactcctgta agcaagagcc aacctcacag 3540 gattaggagc tggggtagaa ctggctatcc ttggggaaga ggcaagccct gcctctggcc 3600 gtgtccacct ttcaggagac tttgagtggc aggtttggac ttggactaga tgactctcaa 3660 aggccctttt agttctgaga ttccagaaat ctgctgcatt tcacatggta cctggaaccc 3720 aacagttcat ggatatccac tgatatccat gatgctgggt gccccagcgc acacgggatg 3780 gagaggtgag aactaatgcc tagcttgagg ggtctgcagt ccagtagggc aggcagtcag 3840 gtccatgtgc actgcaatgc caggtggaga aatcacagag aggtaaaatg gaggccagtg 3900 ccatttcaga ggggaggctc aggaaggctt cttgcttaca ggaatgaagg ctgggggcat 3960 tttgctgggg ggagatgagg cagcctctgg aatggctcag ggattcagcc ctccctgccg 4020 ctgcctgctg aagctggtga ctacggggtc gccctttgct cacgtctctc tggcccactc 4080 atgatggaga agtgtggtca gaggggagca atgggctttg ctgcttatga gcacagagga 4140 attcagtccc caggcagccc tgcctctgac tccaagaggg tgaagtccac agaagtgagc 4200 tcctgcctta gggcctcatt tgctcttcat ccagggaact gagcacaggg ggcctccagg 4260 agaccctaga tgtgctcgta ctccctcggc ctgggatttc agagctggaa atatagaaaa 4320 tatctagccc aaagccttca ttttaacaga tggggaaagt gagcccccaa gatgggaaag 4380 aaccacacag ctaagggagg gcctggggag ccccacccta gcccttgctg ccacaccaca 4440 ttgcctcaac aaccggcccc agagtgccca ggcactcctg aggtagcttc tggaaatggg 4500 gacaagtccc ctcgaaggaa aggaaatgac tagagtagaa tgacagctag cagatctctt 4560 ccctcctgct cccagcgcac acaaacccgc cctccccttg gtgttggcgg tccctgtggc 4620 cttcactttg ttcactacct gtcagcccag cctgggtgca cagtagctgc aactccccat 4680 tggtgctacc tggctctcct gtctctgcag ctctacaggt gaggcccagc agagggagta 4740 gggctcgcca tgtttctggt gagccaattt ggctgatctt gggtgtctga acagctattg 4800 ggtccacccc agtccctttc agctgctgct taatgccctg ctctctccct ggcccacctt 4860 atagagagcc caaagagctc ctgtaagagg gagaactcta tctgtggttt ataatcttgc 4920 acgaggcacc agagtctccc tgggtcttgt gatgaactac atttatcccc tttcctgccc 4980 caaccacaaa ctctttcctt caaagagggc ctgcctggct ccctccaccc aactgcaccc 5040 atgagactcg gtccaagagt ccattcccca ggtgggagcc aactgtcagg gaggtctttc 5100 ccaccaaaca tctttcagct gctgggaggt gaccataggg ctctgctttt aaagatatgg 5160 ctgcttcaaa ggccagagtc acaggaagga cttcttccag ggagattagt ggtgatggag 5220 aggagagtta aaatgacctc atgtccttct tgtccacggt tttgttgagt tttcactctt 5280 ctaatgcaag ggtctcacac tgtgaaccac ttaggatgtg atcactttca ggtggccagg 5340 aatgttgaat gtctttggct cagttcattt aaaaaagata tctatttgaa agttctcaga 5400 gttgtacata tgtttcacag tacaggatct gtacataaaa gtttctttcc taaaccattc 5460 accaagagcc aatatctagg cattttcttg gtagcacaaa ttttcttatt gcttagaaaa 5520 ttgtcctcct tgttatttct gtttgtaaga cttaagtgag ttaggtcttt aaggaaagca 5580 acgctcctct gaaatgcttg tcttttttct gttgccgaaa tagctggtcc tttttcggga 5640 gttagatgta tagagtgttt gtatgtaaac atttcttgta ggcatcacca tgaacaaaga 5700 tatattttct atttatttat tatatgtgca cttcaagaag tcactgtcag agaaataaag 5760 aattgtctta aatgtc 5776 <210> 17 <211> 2695 <212> DNA <213> Human <400> 17 gcgggcttta gcgccttttc tggcggcggt agatttgaag cgcttcaaag gaccggaccc 60 agagaagagg aaaactctac cggtgcagga gcacagggat cagttgtcct tgtttttttt 120 tggtcttttc ttcatttgaa gattaagtat tggagccatg ggaataaagg ttcaacgtcc 180 tcgatgtttt tttgacattg ccattaacaa tcaacctgct ggaagagttg tctttgaatt 240 attttctgat gtgtgcccca aaacatgcga gaactttcgt tgtctttgta caggtgaaaa 300 ggggaccggg aaatcaactc agaaaccatt acattataag agttgtctct ttcacagagt 360 tgtcaaggat tttatggttc aaggtggtga cttcagtgaa ggaaatggac gaggagggga 420 atctatctat ggaggatttt ttgaagacga gagtttcgct gttaaacaca acaaagaatt 480 tctcttgtca atggccaaca gagggaagga tacaaatggt tcacagttct tcataacaac 540 gaaaccaact cctcatttag atgggcatca tgttgttttt ggacaagtaa tctctggtca 600 agaagttgta agagagattg aaaaccagaa aacagatgca gctagcaaac cgtttgcgga 660 ggtacggata ctcagttgtg gagagctgat tcccaaatct aaagttaaga aagaagaaaa 720 gaaaaggcat aaatcatcat catcttcctc ctcctcatct agtgactcag atagctcaag 780 tgattctcag tcctcttctg attcctctga ttccgaaagt gctactgaag agaaatcaaa 840 gaaaagaaaa aagaaacatc ggaaaaattc ccgaaaacac aagaaagaaa agaaaaagcg 900 aaagaaaagc aagaagagtg catctagtga gagtgaagct gaaaatcttg aagcacaacc 960 ccagtctact gtccgtccag aagagatccc tcctatacct gaaaatagat tcctaatgag 1020 aaaaagtcct cctaaagctg atgagaagga aaggaaaaac agagagagag aaagggaaag 1080 agagtgtaat ccacctaact cccagcctgc ttcataccag agacgacttt tagttactag 1140 atctggcagg aaaattaaag gaagaggacc aaggcgttat cgaactcctt ccagatccag 1200 atcaagggat cgtttcagac gtagtgagac tcctccacat tggaggcaag agatgcagag 1260 agctcaaaga atgagggtat caagtggtga aagatggatc aagggggata agagtgagtt 1320 gaatgaaata aaagaaaatc agagaagtcc agttagagta aaagagagaa aaataacaga 1380 tcacaggaat gtatctgaga gtccaaacag aaaaaatgaa aaggagaaga aagttaaaga 1440 ccataaatct aacagcaaag agagagacat cagaagaaat tcagaaaaag atgacaagta 1500 taaaaacaaa gtgaagaaaa gggccaaatc taaaagtagg agtaagagca aagagaaatc 1560 aaagagtaaa gaaagagatt caaaacataa tagaaatgaa gaaaagagga tgaggtcaag 1620 gagtaaagga agggatcatg aaaatgttaa agaaaaagaa aagcagtctg attctaaagg 1680 aaaagatcag gaaaggagta gaagtaaaga gaagtctaaa cagttagaat caaagagtaa 1740 tgagcatgat cacagtaaaa gtaaggaaaa ggatagacgc gcacaatcca ggagtagaga 1800 atgtgatata actaaaggta aacacagtta taatagcaga acaagagaac gaagcagaag 1860 tagggacaga agcagaagag tgcgatcaag aacccatgac agagatcgca gcagaagcaa 1920 ggagtaccat agatacagag aacaggaata caggagaaga ggacggtcac gaagccgaga 1980 gagaagaaca ccaccaggaa gatcaagaag taaagatagg aggagaagga ggagagactc 2040 acggagctca gagagagaag aaagtcaaag cagaaacaaa gacaaataca gaaaccaaga 2100 gagtaagagc tcacacagaa aagaaaattc tgagagtgag aaaagaatgt actctaaaag 2160 tcgtgatcat aatagctcaa ataacagcag ggaaaaaaag gctgatagag atcaaagtcc 2220 cttctcaaaa ataaaacaaa gcagtcagga cgatgaatta aagtcctcca tgttgaaaaa 2280 taaggaggat gagaagatca gatcctcagt ggaaaaagaa aaccaaaaat caaaaggtca 2340 agaaaatgac catgtacatg aaaaaaataa aaaatttgat catgaatcaa gccctggaac 2400 agatgaagac aaaagcggat gagtgagtta tataaactta cttccattct gtttcggatt 2460 ttaagtttga gagacttgct aatgaatctc ctttatgttg ttttcctttt cattgttttt 2520 ggattgtttt atgtttgtcc ttttttttct taatgtggat ttcattgagt tgattttttg 2580 ataatctgca atctggataa tttgtactgc taaagtttta ataaactcga catgagaaaa 2640 acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2695 <210> 18 <211> 1635 <212> DNA <213> Human <400> 18 ggcacgagcg cggcgttcac gggaattgtt cgctttagtg ccggcgccat ggggtcggag 60 ctgatcgggc gcctagcccc gcgcctgggc ctcgccgagc ccgacatgct gaggaaagca 120 gaggagtact tgcgcctgtc ccgggtgaag tgtgtcggcc tctccgcacg caccacggag 180 accagcagtg cagtcatgtg cctggacctt gcagcttcct ggatgaagtg ccccttggac 240 agggcttatt taattaaact ttctggtttg aacaaggaga catatcagag ctgtcttaaa 300 tcttttgagt gtttactggg cctgaattca aatattggaa taagagacct agctgtacag 360 tttagctgta tagaagcagt gaacatggct tcaaagatac taaaaagcta tgagtccagt 420 cttccccaga cacagcaagt ggatcttgac ttatccaggc cacttttcac ttctgctgca 480 ctgctttcag catgcaagat tctaaagctg aaagtggata aaaacaaaat ggtagccaca 540 tccggtgtaa aaaaagctat atttgatcga ctgtgtaaac aactagagaa gattggacag 600 caggtcgaca gagaacctgg agatgtagct actccaccac ggaagagaaa gaagatagtg 660 gttgaagccc cagcaaagga aatggagaag gtagaggaga tgccacataa accacagaaa 720 gatgaagatc tgacacagga ttatgaagaa tggaaaagaa aaattttgga aaatgctgcc 780 agtgctcaaa aggctacagc agagtgattt cagcttccaa actggtatac attccaaact 840 gatagtacat tgccatctcc aggaagactt gacggctttg ggattttgtt taaactttta 900 taataaggat cctaagactg ttgcctttaa atagcaaagc agcctacctg gaggctaagt 960 ctgggcagtg ggctggcccc tggtgtgagc attagaccag ccacagtgcc tgattggtat 1020 agccttatgt gctttcctac aaaatggaat tggaggccgg gcgcagtggc tcacgcctgt 1080 aatcccagca ctttgggagg ccaaggtggg tggatcacct gaggtcagga gctcgagacc 1140 agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaatta gccaggtgtg 1200 atggtgcatg cctgtaatcc cagctcctca gtaggctgag acaggagcat cacttgaacg 1260 tgggaggcag aggttgcagt gagccgagat tgcaccaccg cactccagcc tgggtgacag 1320 agcgagactt atctcataaa taaatagata gatactccag cctgggtgac agagcgagac 1380 ttatagatag atagatagat agatggatag atagatagat agatagatag atagataaac 1440 ggaattggag ccattttgct ttaagtgaat ggcagtccct tgtcttattc agaatataaa 1500 attcagtctg aatggcatct tacagatttt acttcaattt ttgtgtacgg tattttttat 1560 ttgactaaat caatatattg tacagcctaa gttaataaat gttatttata tatgcaaaaa 1620 aaaaaaaaaa aaaaa 1635 <210> 19 <211> 3165 <212> DNA <213> Human <400> 19 ggggatttgg ctagaaggct gggccggcag cggttgtgag gagttagctc gcggcattgc 60 aggctctgag aggaggggac ccggttcccg ggtgagtgtc caggcatgcc agcggaacgg 120 cccgcgggca gcggcggctc ggaggctcca gcaatggttg aacaactgga cactgctgtg 180 attaccccgg ccatgctaga agaggaagaa cagcttgaag ctgctggact agagagagag 240 cggaagatgc tggaaaaggc tcgcatgtct tgggatagag agtcgacaga aattcggtac 300 cgtagacttc aacatttgct tgaaaaaagc aatatatact ccaaattttt attgacgaaa 360 atggaacagc aacaattaga ggaacagaag aagaaagaaa aattggagag aaaaaaggag 420 tctttaaaag ttaaaaaggg taaaaattca attgatgcaa gtgaagagaa gccagttatg 480 aggaaaaaaa gaggaagaga agatgaatca tacaatattt cagaggtcat gtcaaaagag 540 gaaattttgt ctgtggctaa aaaaaataaa aaggagaatg aggatgaaaa ctcctcctct 600 actaatctct gtgtggaaga tcttcagaaa aataaagatt cgaatagtat aattaaagat 660 agattgtctg aaacggttag gcagaatact aaattctttt ttgacccagt ccggaagtgt 720 aatggtcagc cagtaccttt tcaacaacca aagcacttca ctggaggagt gatgcgatgg 780 taccaagtag aaggcatgga atggcttagg atgctttggg aaaatggaat taatggcatt 840 ttagcagatg aaatgggatt gggtaagaca gttcagtgca ttgctactat tgcattgatg 900 attcagagag gagtaccagg accttttctt gtctgtggcc ctttgtctac acttcctaac 960 tggatggctg aattcaaaag atttacacca gatatcccta caatgttata tcatggaacc 1020 caggaggaac gtcaaaaatt ggtaagaaat atttacaaac ggaaagggac tttgcagatt 1080 catcctgtgg taatcacgtc atttgaaata gccatgagag accgaaatgc gttacagcat 1140 tgctattgga aatacttaat agtagatgaa ggacacagga ttaagaatat gaagtgccgt 1200 ctaatcaggg agttaaaacg attcaatgct gataacaaac ttcttttgac tggtactccc 1260 ttgcaaaaca atttatcaga actttggtca ttgctaaact ttttgttgcc agatgtattt 1320 gatgacttga aaagctttga gtcttggttt gacatcacta gtctttctga aactgctgaa 1380 gatattattg ctaaagaaag agaacagaat gtattgcata tgctgcacca gattttaaca 1440 cctttcttat tgagaagact gaagtctgat gttgctcttg aagttcctcc taaacgagaa 1500 gtagtcgttt atgctccact ttcaaagaag caggagatct tttatacagc cattgtgaac 1560 cgtacaattg caaacatgtt tggatccagt gagaaagaaa caattgagtt aagtcctact 1620 ggtcgaccaa aacgacgaac tagaaaatca ataaattaca gcaaaataga tgatttccct 1680 aatgaattgg aaaaactgat cagtcaaata cagccagagg tggaccgaga aagagctgtt 1740 gtggaagtga atatccctgt agaatctgaa gttaatctga agctgcagaa tataatgatg 1800 ctacttcgta aatgttgtaa tcatccatat ttgattgaat atcctataga ccctgttaca 1860 caagaattta agatcgatga agaattggta acaaattctg ggaagttctt gattttggat 1920 cgaatgctgc cagaactaaa aaaaagaggt cacaaggtgc tgcttttttc acaaatgaca 1980 agcatgttgg acattttgat ggattactgc catctcagag atttcaactt cagcaggctt 2040 gatgggtcca tgtcttactc agagagagaa aaaaacatgc acagcttcaa cacggatcca 2100 gaggtgttta tcttcttagt gagtacacga gctggtggcc tgggcattaa tctgactgca 2160 gcagatacag ttatcattta tgatagtgat tggaaccccc agtcggatct tcaggcccag 2220 gatagatgtc atagaattgg tcagacaaag ccagttgttg tttatcgcct tgttacagca 2280 aatactatcg atcagaaaat tgtggaaaga gcagctgcta aaaggaaact ggaaaagttg 2340 atcatccata aaaatcattt caaaggtggt cagtctggat taaatctgtc taagaatttc 2400 ttagatccta aggaattaat ggaattatta aaatctagag attatgaaag ggaaataaaa 2460 ggatcaagag agaaggtcat tagtgataaa gatctagagt tgttgttaga tcgaagtgat 2520 cttattgatc aaatgaatgc ttcaggacca attaaagaga agatggggat attcaagata 2580 ttagaaaatt ctgaagattc cagtcctgaa tgtttgtttt aaagtggagc tcaagaatag 2640 cttttaaaag ttcttattta catctagtga tttccctgta ttgggtttga aatactgatt 2700 gtccacttca ccttttttat tatatcagtt gacatgtaac tagtaccatg cgtacttaaa 2760 tagatggtaa ttttctgagc cttaccaaga acaaagaagt atccatatta agtttagatt 2820 ttcagttaat ttttgagact gagtagtatt cttggataca ggctgatgtg tacttaacca 2880 cttccagatt tatacagtct tcctgtggaa gtttagtaaa tgtctttttc cctcctttct 2940 tctagtaatg cagttcatgg gctttaggta cttcagttat gaagtaggct tttcatgggg 3000 agagattggg attatgctct ctgttgttta agaaactgtt tgattttaga gtctatttct 3060 atgagatagt ttaccaaata aatgttcctt ataagatgaa aaaaaaaaaa aaaaaaaaaa 3120 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 3165 <210> 20 <211> 526 <212> DNA <213> Human <400> 20 tggttcctgc cgtccggact ctttttcctc tactgagatt catctgtgtg aaatatgagt 60 tggcgaggaa gatcgaccta ttattggcct agaccaaggc gctatgtaca gcctcctgaa 120 atgattgggc ctatgcggcc cgagcagttc agtgatgaag tggaaccagc aacacctgaa 180 gaaggggaac cagcaactca acgtcaggat cctgcagctg ctcaggaggg agaggatgag 240 ggagcatctg caggtcaagg gccgaagcct gaagctcata gccaggaaca gggtcaccca 300 cagactgggt gtgagtgtga agatggtcct gatgggcagg agatggaccc gccaaatcca 360 gaggaggtga aaacgcctga agaaggtgaa aagcaatcac agtgttaaaa gaaggcacgt 420 tgaaatgatg caggctgctc ctatgttgga aatttgttca ttaaaattct cccaataaag 480 ctttacagcc ttctgcaaag aaaaaaaaaa aaaaaaaaaa aaaaaa 526 <210> 21 <211> 4834 <212> DNA <213> Human <400> 21 cgaggtcaga ggggaggagg actctggagc tgacagcgcg cacttcaccc gcagttgttc 60 tagcgactgc gaagatagct cgctgagctg gaaccccaca gatcaccaac aaaaatgaag 120 gcggcagatg agcctgccta cctgacagtg ggaaccgatg tcagtgccaa gtaccgaggt 180 gccttctgtg aggcaaagat taagactgtg aaaaggctgg tgaaagttaa ggtactcctg 240 aaacaggata ataccacaca attggtacaa gatgaccaag taaagggtcc tttaagagtt 300 ggagctattg ttgaaacaag gacatctgat ggatcttttc aggaagctat tatcagcaag 360 ttgacagatg ctagttggta taccgtggtg tttgatgatg gtgatgagcg aacattgaga 420 cgtacctcac tttgtctgaa aggagagaga cattttgcag agagtgagac acttgaccag 480 cttccattaa caaatccaga gcattttgga actccagtaa ttgcaaagaa gacgaacaga 540 ggaaggagat cttctcttcc tgttactgaa gatgaaaagg aagaagaaag cagtgaagag 600 gaagatgaag acaagcgccg tctcaatgat gaattactag gaaaagttgt aagtgtggtg 660 tctgcaacgg agaggactga atggtatcct gctttggtaa tatctcccag ctgtaatgat 720 gacatcacag tgaaaaagga tcagtgttta gttcgatcat ttattgattc taaattttac 780 tctatagcaa gaaaggacat taaggaagta gacattctca atctaccgga atctgagctc 840 tccactaaac cagggcttca gaaagcaagc atcttcttaa aaactagagt tgttcctgat 900 aattggaaaa tggatataag tgaaatcctt gagtcatcca gtagtgatga tgaagatggc 960 ccagctgaag aaaatgatga agagaaggaa aaggaggcca aaaagacaga agaagaggtg 1020 cctgaggaag aacttgatcc tgaagagagg gacaacttcc tccagcagct ttataagttt 1080 atggaagaca gaggtactcc aatcaacaaa ccacctgttt tgggctataa agatctcaat 1140 ctcttcaaac tcttcagact ggtttatcat cagggtggat gtgacaatat tgatagtggt 1200 gctgtatgga agcaaattta tatggacctt ggcattccta ttttgaattc agctgcttcc 1260 tacaatgtaa aaactgctta tagaaagtat ctctatggtt ttgaggagta ctgccgttcg 1320 gcaaatattc agttcagaac tgttcatcac catgaaccaa aagtaaaaga ggaaaaaaaa 1380 gacttagaag aatcaatgga agaggctctc aaattagatc aagaaatgcc tttaacagaa 1440 gtgaagagtg aacctgagga aaatatcgat tcaaacagtg aaagtgaaag agaagagata 1500 gaattaaaat ctccgagggg acgaaggaga attgctcgag atgtaaattc tattaaaaag 1560 gaaattgaag aagagaaaac agaagacaaa ttaaaagata atgatacaga aaataaggat 1620 gtagatgatg actatgaaac tgcagagaaa aaagaaaatg agctactact ggggagaaaa 1680 aatacaccaa agcaaaaaga gaagaaaatt aaaaaacagg aggattctga caaagactca 1740 gatgaagagg aagagaaaag ccaagagagg gaagaaactg aaagcaaatg tgactctgaa 1800 ggagaggaag atgaggaaga catggaaccc tgcctaacag gaaccaaagt gaaagtaaaa 1860 tatggacgag ggaagactca gaaaatttat gaagccagta ttaaaagcac tgaaattgat 1920 gacggagaag ttttatattt ggtacattac tatggatgga atgtcaggta tgatgagtgg 1980 gtgaaggctg acaggataat ctggcctttg gacaaaggtg gaccaaagaa aaaacagaag 2040 aaaaaagcta aaaataaaga agatagtgaa gtggacgaaa agagagatga ggagaggcag 2100 aagtcaaaac ggggacgacc tcctttaaaa tcaaccctct catcaaacat gccgtatggc 2160 ttatctaaga cagcaaacag tgaaggaaaa tcagactctt gttcatctga tagtgaaaca 2220 gaagatgctt tagaaaagaa tttaataaat gaagaacttt ctcttaaaga tgaactagaa 2280 aaaaatgaaa atttgaatga tgataagcta gatgaagaaa atccaaagat ttctgcacat 2340 atattaaaag aaaatgatag gactcaaatg cagcctttag aaaccctgaa gttagaagtt 2400 ggagagaatg aacaaatagt acagattttt gggaacaaaa tggaaaaaac agaagaagtt 2460 aagaaagaag ccgaaaaatc tccaaaagga aagggaagac gaagcaagac aaaagatctt 2520 tctttagaaa ttataaagat ttcatcattt ggccagaatg aagcaggaag tgaacctcat 2580 atagaagctc atagtcttga attgtcttca ttagacaata aaaacttttc ttctgctaca 2640 gaagatgaaa ttgaccaatg tgtgaaagaa aagaagttga aacggaaaat actaggacaa 2700 tcatcgccag agaaaaaaat aagaattgag aatggaatgg aaatgacaaa tactgtatct 2760 caagaaagga ccagtgattg tattggatct gagggaatga aaaacttaaa ttttgaacag 2820 cactttgaaa gagaaaatga aggaatgcca tcattgatag cagagtcaaa ccaatgcatc 2880 caacaactga ctagtgaaag atttgatagt ccagctgaag aaactgtaaa tattccacta 2940 aaagaagatg aggatgcaat gcctctgatc gggcctgaaa ccttggtttg ccatgaagta 3000 gatttggatg atttggatga aaaggataag accagcattg aggatgtagc agttgaaagc 3060 tctgagtcta actctcttgt ttctattcca cctgccctac ctcctgtagt ccaacataac 3120 ttttcagtag cttcaccact tactcttagt caagatgagt ctcgaagcgt aaaaagtgag 3180 agtgatataa cgattgaagt tgatagtatt gctgaagaat ctcaagaagg tctctgtgag 3240 agggaatcgg caaatggatt tgaaactaat gttgcctctg gtacctgtag tataattgta 3300 caagagagag agagcagaga gaagggtcag aagaggccaa gtgatggaaa tagtggatta 3360 atggcaaaaa agcaaaagcg taccccaaag cgaacaagtg ctgcagccaa aaatgaaaag 3420 aatggaacag gacaaagcag tgatagtgaa gatcttcctg tcctagacaa ttcaagtaaa 3480 tgtaccccag taaagcatct taatgtatct aagccacaga aacttgcacg atctcctgca 3540 agaatatccc cgcacatcaa agatggagag aaagataaac acagagaaaa acatccgaat 3600 tcatccccta ggacatataa atggagcttt cagctcaatg aattagataa tatgaacagt 3660 acagagagaa tctcatttct ccaagaaaaa ctacaggaaa tcagaaaata ttatatgtct 3720 ttgaagtctg aagttgcaac catagacagg aggagaaaaa gattaaaaaa gaaagacagg 3780 gaagtgtctc atgcgggagc ctccatgtca tctgcttcat cagacactgg aatgagtccc 3840 tcatcatcgt ctcccccaca aaatgtactt gctgtagaat gtaggtgata aacattttct 3900 ctaccttccc agcagtttgc tgccatggac ataaatcccc aaaccctgaa ttacaaccac 3960 agaaagcact caactggttt gacattgcta agtatatcct gtatactttt ccaggctgga 4020 ttgtatctat gcccctctct cttctttttt cttgttgcaa aaaataagct gattaataag 4080 tgaaggttaa gcagcctgcc atatttgtca taatttttcc tctttacttt tgtttttcgt 4140 ttgttgtgat atagaacaaa gggcacttag caaatttgaa tttgtataat aaagctttca 4200 ggtgttacag aaatcgtaga caagcaagtg cacatgataa acaatcaaaa tattacccag 4260 ctgaatagtt actgctgcac tttcactaag atgtatttga acacttggtg agtagggggt 4320 ttatgttgtg ttttttttca ttatcgtttt ttttattttt gtgaagcact tgctatttag 4380 aactgccaaa gtatatgttc agcagtgtgc ccaggattga aggtgtaaat gggacaaaat 4440 aaattgtgaa aggaagtgta gttgactgaa aactacagtt gtaataagtc ttccactttt 4500 tataggattt ttgagcacac aattatgcaa atattttaat gtttattaat gtttacagtg 4560 gaattgtgaa taagttttca gtggactatc ttatcccttg acaaaaatat tttgtctttt 4620 ttctatgtaa tttcagagtt tttattttgt tacaaaaaga caaaaatgaa atatataaca 4680 acaatgaagt tatttaacaa gatttctaaa gctgaaattt ttgtgtaaaa taaggtatta 4740 tcttgcaact tgttaaatat atttattcag acattggatg ttgtattttt atgtattttt 4800 taaaatatta ataaaattta aaaaaaaaaa aaaa 4834 <210> 22 <211> 1713 <212> DNA <213> Human <400> 22 ggggggtgtg agccacgggc tgccgggggc ctggggctcg gcgtcggtcc ccgggggatg 60 tggagagctg gcagcatgtc ggccgagctg ggagtcgggt gcgcattgcg ggcggtgaac 120 gagcgcgtgc agcaggctgt ggcgcggcgg ccgcgggatc tcccagccat ccagccccgg 180 ctagtggcgg tcagcaaaac caaacctgca gacatggtga tcgaggccta tggacatggg 240 cagcgcactt ttggcgagaa ctacgttcag gaactgctag aaaaagcatc aaatcccaaa 300 attctgtctt tgtgtcctga gatcaaatgg cacttcattg gccacctaca gaaacaaaat 360 gtcaacaaat tgatggctgt ccccaatctc ttcatgctgg aaacagtgga ttctgtgaag 420 ttggcagaca aagtgaacag ttcctggcag agaaaaggtt ctcctgaaag gttaaaggtt 480 atggtccaga ttaacaccag cggagaagag agtaaacatg gccttccacc ttcagagacc 540 atagccatcg tggagcacat aaacgccaag tgtcctaacc tggagtttgt ggggctgatg 600 accataggaa gctttgggca tgatcttagt caaggaccaa atccagactt ccagctgtta 660 ttgtccctcc gggaggagct gtgtaaaaag ctgaacatcc ctgctgacca ggttgagctg 720 agcatgggca tgtccgcgga tttccagcat gcggttgaag taggatctac aaatgtccga 780 ataggaagca cgatttttgg agagcgggat tactcaaaga aacccacccc ggacaagtgc 840 gcagcagacg tgaaggcccc gctggaggtg gcacaggagc actgagccag ggaatactga 900 gagcactaac tatgcactaa cctagatttt catttcgata ttccctgtgt cccagcgcag 960 tcctgctctc ctgtgacctg tggagagcac taatgatcac gtgtgttgat ggaaaccatc 1020 tgtgcttagt ctctgacata ggaagcttgc ttcaggcaat ggctttggat tgagtttgag 1080 aaattcaaac atttctgcag aacagatacc aaatcaatag ctaggaatca tgttcaatat 1140 tgaattctgc ccaggagcat gaactgatcc atgaatgcct tttccaggtt aaaatttggt 1200 cactgatgcc tataatcgtg gaagtcagag ggattcccct ttttcatctc attttaatag 1260 gaaaattcct tatggttaac atctccctac aaactcctac tacgtcgtct aaattgctgc 1320 tctggaataa ggtgatttct gcccccagat tcttccctag ccggtagata cgtgaagata 1380 ttcccaactg tggaatggca gtgtaggtag cttcaggaaa tggctcaggt taattctcaa 1440 aacacaaatt gttgctggcc aggcatggtg actcatgcct gtaatcccag caatttggga 1500 gacagaggcg gaaggatcac ctgagcctag gagttcaaga ccagcctcag caacagcagg 1560 agccccaccc cccgtctcta caaaaatatt taaaaattaa ctgggcatgg tggctgaggt 1620 ggaagaatgg aagaatcact tgagcccagg agtttgaggc tgcagtgagc tatgattgca 1680 ccactgtact cctgccttaa aaaaaaaaaa aaa 1713 <210> 23 <211> 4344 <212> DNA <213> Human <400> 23 gggatctgct agaagttggt cttccgccag gactagagtt tcctcgcggt aacagcctcc 60 gtggcctccg gaggaccatg tcattagact ttggcagtgt ggcactacca gtgcaaaatg 120 aagatgaaga gtatgacgaa gaggactatg aaagagagaa agagttgcag cagttactca 180 cagaccttcc ccatgacatg ctggatgacg acctctcctc tccagagctc cagtattcgg 240 actgcagcga ggatggcaca gacggacaac cacatcatcc tgagcaattg gagatgagct 300 ggaatgagca aatgctgccc aaatctcaaa gtgtaaatgg tcccagttgt caaggtttgg 360 aaccgtataa taaagtgaca tataaacctt atcagtcttc tgcccagaat aatggctcac 420 cagcccagga gataacagga agtgacacat tcgaaggcct gcaacaacaa tttttaggag 480 ctaatgagaa ctctgcagaa aatatgcaga ttattcaact tcaggttctt aacaaagcaa 540 aagagagaca actggagaac ttaattgaaa agttaaatga aagtgaacgt caaattcgat 600 atctgaatca ccagcttgta ataataaaag atgaaaagga tggtttgact ctcagccttc 660 gagaatcaca gaaactcttt cagaatggaa aagaaagaga gatacagctt gaagctcaaa 720 taaaagcact ggagactcag atacaagcat taaaagtcaa tgaagaacag atgatcaaga 780 agtccagaac aactgaaatg gctctggaaa gcttgaagca gcagctggtg gaccttcatc 840 attctgaatc acttcaacga gctagagaac agcatgagag cattgttatg ggcctcacaa 900 agaagtacga agagcaagta ttgtccttac aaaagaattt ggatgccaca gtcaccgcac 960 ttaaagaaca ggaagacatt tgctctcgtc tgaaagatca cgtgaaacaa ctggaaagga 1020 atcaagaagc aatcaagtta gaaaagactg agatcattaa taagttgaca agaagtctag 1080 aggagagtca aaagcagtgt gcccacttgt tgcagtccgg gtcagtacaa gaggtggctc 1140 agctacagtt ccagctgcag caagcacaga aggcacatgc tatgagtgca aacatgaaca 1200 aggctttgca agaagaatta acagaactaa aagatgaaat ttctctctat gaatctgctg 1260 caaaactagg aatacatcca agtgactcag aaggagaatt aaatatagaa ctcactgaat 1320 cgtatgtgga tttgggtatt aaaaaggtca actggaaaaa atccaaagtt accagcattg 1380 tacaagaaga agacccaaat gaagagcttt caaaagatga gttcattctg aagttaaagg 1440 cagaagtaca gcgtttgctg ggtagcaact caatgaagcg tcatctggtg tctcagttac 1500 aaaatgacct caaagactgt cataagaaaa ttgaagatct ccaccaagtg aagaaggatg 1560 aaaaaagcat tgaggttgag actaaaacag atacctcaga aaaaccaaag aatcaattat 1620 ggcctgagtc ttctacttct gatgttgtca gagatgatat tctgctgctt aaaaatgaaa 1680 ttcaagtttt acaacaacaa aatcaggaac ttaaagaaac tgaaggaaaa ctgagaaata 1740 caaatcaaga cttatgtaat caaatgagac aaatggtaca agattttgac catgacaaac 1800 aagaagctgt ggataggtgt gaaaggactt atcagcagca ccatgaagcc atgaaaactc 1860 aaatacgtga aagcctatta gcaaagcatg ctttggagaa gcagcagctc tttgaggctt 1920 atgagagaac tcatttgcaa ctgaggtctg agttggataa gttgaataag gaggtgactg 1980 ctgtgcagga atgttaccta gaagtgtgca gagagaagga taatctagaa ttgactctca 2040 ggaagaccac tgaaaaggag caacagactc aggagaagat caaagaaaaa ctcattcaac 2100 agcttgaaaa ggagtggcag tctaagctgg atcaaactat aaaggcaatg aaaaagaaga 2160 ccttagattg tggcagccaa actgaccaag taaccaccag tgatgttatt tccaagaaag 2220 agatggcaat tatgatagaa gagcagaagt gcacaatcca gcaaaactta gaacaagaga 2280 aggacatagc catcaagggg gctatgaaga aactcgaaat tgaattggaa ctcaaacatt 2340 gtgaaaatat taccaaacag gtagaaatag ctgtgcaaaa tgctcatcag cgatggctgg 2400 gagaactacc agagctggca gagtatcaag cacttgtgaa ggcagaacag aaaaagtggg 2460 aagaacagca tgaggtctct gtgaacaaaa ggatatcatt tgctgtttct gaagctaaag 2520 agaaatggaa gagtgagctt gaaaatatga ggaaaaatat acttcctgga aaggaattgg 2580 aagagaagat tcattctctt cagaaggaac ttgagttaaa gaacgaagaa gtccctgtgg 2640 tcatcagggc tgagttagct aaggctcgga gtgaatggaa caaagaaaag caagaagaaa 2700 tccacagaat ccaagaacaa aatgagcaag attaccggca atttttagat gatcaccgaa 2760 ataaaattaa tgaggtgctt gcggcagcta aagaagactt tatgaaacaa aaaactgaac 2820 tacttcttca gaaggagaca gaattacaaa cttgtctaga ccagagtcgt agagaatgga 2880 ctatgcagga agccaagcgg atccaactgg aaatctatca gtatgaggaa gacatcctga 2940 ctgtacttgg ggttctttta agtgataccc aaaaggagca catcagtgat tctgaggaca 3000 agcagctttt ggaaatcatg tcgacttgtt cttcaaaatg gatgtctgtg caatattttg 3060 aaaaactaaa gggctgcata cagaaagcat ttcaagatac acttcctctg cttgtagaaa 3120 acgctgaccc agaatggaaa aagagaaata tggccgagct ctctaaggat tctgccagcc 3180 agggcactgg ccaaggagac cctggacctg ctgctggaca ccatgctcag cccttggcct 3240 tacaagcaac agaagcagaa gctgataaga aaaaggtcct tgaaattaag gatttatgct 3300 gtggacactg cttccaagaa cttgaaaagg caaagcagga atgtcaagat ctgaaaggaa 3360 aactggagaa atgctgtagg catcttcagc atttagaaag gaagcacaaa gctgtagtgg 3420 aaaaaattgg agaagagaat aataaagttg ttgaagaatt aatagaagaa aacaacgaca 3480 tgaagaataa attggaagaa ttgcaaacac tttgtaaaac accaccaagg tcattgtcag 3540 caggggccat tgaaaatgct tgcctgccat gcagtggggg agccttggaa gaacttcgtg 3600 ggcagtacat taaagctgta aaaaaaatta aatgtgacat gcttcgttat attcaggaga 3660 gtaaggaacg agctgcagaa atggtaaaag cagaggtact gcgagaacgt caagaaaccg 3720 cccgaaagat gcgcaaatat tatttgattt gcctccaaca gattttgcag gatgatggaa 3780 aagaaggggc tgagaaaaag attatgaatg ctgctagcaa acttgctaca atggcaaaat 3840 tactggaaac acctatttct agtaagtccc aaagcaaaac tacacagtca ggtatgtcaa 3900 agtgagtcgc caaatggttt ttctatcttt tcttctttag ctatttaata ttttcagtat 3960 gaagaaggca gggaaggtaa ggagtgagag ttaatttgtg aagttttgta tgttttactt 4020 aaactagaag tttacgcaaa aagagtacac agtttccaat ttaagtaggc agactgagca 4080 tgcccatcag tttcctattg ctgcttccat ccctcgaaat gatagaaaag attttaaaca 4140 gcaaataaag aatgagaaaa agaagaaatt ataagtgggt tttaaaaagt tgcagtgggc 4200 caggcatcat ggctcacacc tgtaatccca gcactttggg aggctgaggt gggaggatcc 4260 cttgatccca ggaatttgag gttgcagtaa gctatgattg tgccactgta ctccagcctg 4320 ggtgacagag tgaggccctg tctc 4344 <210> 24 <211> 552 <212> DNA <213> Human <400> 24 ctcatatttc acacagatga gttggcgagg aagatcgacc tattattggt ctaggccaat 60 aataggtcga tcttcctcgc caactcatat ttcacacaga tgaatctcag tagaggaaaa 120 tcgacctatt attggcctag accaaggcgc tatgtacagc ctcctgaagt gattgggcct 180 atgcggcccg agcagttcag tgatgaagtg gaaccagcaa cacctgaaga aggggaacca 240 gcaactcaac gtcaggatcc tgcagctgct caggagggag aggatgaggg agcatctgca 300 ggtcaagggc cgaagcctga agctgatagc caggaacagg gtcacccaca gactgggtgt 360 gagtgtgaag atggtcctga tgggcaggag atggacccgc caaatccaga ggaggtgaaa 420 acgcctgaag aaggtgaaaa gcaatcacag tgttaaaaga aggcacgttg aaatgatgca 480 ggctgctcct atgttggaaa tttgttcatt aaaattctcc caataaagct ttacagcctt 540 ctgcaaagaa aa 552 <210> 25 <211> 2899 <212> DNA <213> Human <400> 25 aaaaaaaaaa gtacgcggac aagatggcgg cggcagcagt cgacagcgcg atggaggtgg 60 tgccggcgct ggcggaggag gccgcgccgg aggtagcggg cctcagctgc ctcgtcaacc 120 tgccgggtga ggtgctggag tacatcctgt gctgcggctc gctgacggcc gccgacatcg 180 gccgtgtctc cagcacctgc cggcggctgc gcgagctgtg ccagagcagc gggaaggtgt 240 ggaaggagca gttccgggtg aggtggcctt cccttatgaa acactacagc cccaccgact 300 acgtcaattg gttggaagag tataaagttc ggcaaaaagc tgggttagaa gcgcggaaga 360 ttgtagcctc gttctcaaag aggttctttt cagagcacgt tccttgtaat ggcttcagtg 420 acattgagaa ccttgaagga ccagagattt tttttgagga tgaactggtg tgtatcctaa 480 atatggaagg aagaaaagct ttgacctgga aatactacgc aaaaaaaatt ctttactacc 540 tgcggcaaca gaagatctta aataatctta aggcctttct tcagcagcca gatgactatg 600 agtcgtatct tgaaggtgct gtatatattg accagtactg caatcctctc tccgacatca 660 gcctcaaaga catccaggcc caaattgaca gcatcgtgga gcttgtttgc aaaacccttc 720 ggggcataaa cagtcgccac cccagcttgg ccttcaaggc aggtgaatca tccatgataa 780 tggaaataga actccagagc caggtgctgg atgccatgaa ctatgtcctt tacgaccaac 840 tgaagttcaa ggggaatcga atggattact ataatgccct caacttatat atgcatcagg 900 ttttgattcg cagaacagga atcccaatca gcatgtctct gctctatttg acaattgctc 960 ggcagttggg agtcccactg gagcctgtca acttcccaag tcacttctta ttaaggtggt 1020 gccaaggcgc agaaggggcg accctggaca tctttgacta catctacata gatgcttttg 1080 ggaaaggcaa gcagctgaca gtgaaagaat gcgagtactt gatcggccag cacgtgactg 1140 cagcactgta tggggtggtc aatgtcaaga aggtgttaca gagaatggtg ggaaacctgt 1200 taagcctggg gaagcgggaa ggcatcgacc agtcatacca gctcctgaga gactcgctgg 1260 atctctatct ggcaatgtac ccggaccagg tgcagcttct cctcctccaa gccaggcttt 1320 acttccacct gggaatctgg ccagagaagg tgcttgacat cctccagcac atccaaaccc 1380 tagacccggg gcagcacggg gcggtgggct acctggtgca gcacactcta gagcacattg 1440 agcgcaaaaa ggaggaggtg ggcgtagagg tgaagctgcg ctccgatgag aagcacagag 1500 atgtctgcta ctccatcggg ctcattatga agcataagag gtatggctat aactgtgtga 1560 tctacggctg ggaccccacc tgcatgatgg gacacgagtg gatccggaac atgaacgtcc 1620 acagcctgcc gcacggccac caccagcctt tctataacgt gctggtggag gacggctcct 1680 gtcgatacgc agcccaagaa aacttggaat ataacgtgga gcctcaagaa atctcacacc 1740 ctgacgtggg acgctatttc tcagagttta ctggcactca ctacatccca aacgcagagc 1800 tggagatccg gtatccagaa gatctggagt ttgtctatga aacggtgcag aatatttaca 1860 gtgcaaagaa agagaacata gatgagtaaa gtctagagag gacattgcac ctttgctgct 1920 gctgctatct tccaagagaa cgagactccg gaagaagacg tctccacgga gccctcggga 1980 cctgctgcac caggaaagcc actccaccag tagtgctggt tgcctcctac taagtttaaa 2040 taccgtgtgc tcttccccag ctgcaaagac aatgttgctc tccgcctaca ctagtgaatt 2100 aatctgaaag gcactgtgtc agtggcatgg cttgtatgct tgtcctgtgg tgacagtttg 2160 tgacattctg tcttcatgag gtctcacagt cgacgctcct gtaatcattc tttgtattca 2220 ctccattccc ctgtctgtct gcatttgtct cagaacattt ccttggctgg acagatgggg 2280 ttatgcattt gcaataattt ccttctgatt tctctgtgga acgtgttcgg tcccgagtga 2340 ggactgtgtg tctttttacc ctgaagttag ttgcatattc agaggtaaag ttgtgtgcta 2400 tcttggcagc atcttagaga tggagacatt aacaagctaa tggtaattag aatcatttga 2460 atttattttt ttctaatatg tgaaacacag atttcaagtg ttttatcttt ttttttttaa 2520 atttaaatgg gaatataaca cagttttccc ttccatattc ctctcttgag tttatgcaca 2580 tctctataaa tcattagttt tctattttat tacataaaat tcttttagaa aatgcaaata 2640 gtgaactttg tgaatggatt tttccatact catctacaat tcctccattt taaatgacta 2700 cttttatttt ttaatttaaa aaatctactt cagtatcatg agtaggtctt acatcagtga 2760 tgggttcttt ttgtagtgag acatacaaat ctgatgttaa tgtttgctct tagaagtcat 2820 actccatggt cttcaaagac caaaaaaatg aggttttgct tttgtaatca ggaaaaaaaa 2880 aaattaatga accttaaag 2899 <210> 26 <211> 2289 <212> DNA <213> Human <400> 26 ttgtaccctt aaaattattt tttcctatgc agaattgact ttgattaaaa aatgtttttg 60 atgactattt tcctgattcg tcagtatatc taattgtgtt catattactc atgaaaaatc 120 ttgtctatga gggacgtatt tttagtaaca tttttatagc atataagaac ttttacagca 180 aaaacaggaa tcattaagtg tgtgtgcttt tatcataact tctcttttaa tggaacttaa 240 aatcttaact cgtgtttttg cagcactttt tttgcacatg gtaggttctt aatatttgaa 300 tggaattcag tgtgactgtt ctttgtgttc tcaaaagtct gatctttgta acaatttgtc 360 tttcacttga gacttttttt ttctttgcat atgtgcacgt ctcactcttg gttttcctta 420 atctttttta actaaacaca tctatgactc atatttccct atttatgaat aggagcaatt 480 taaaatttcc caacatggtg gtatgtgatg taacataacc aaaggctaca tgtttaccct 540 tgtttaatta cccttcattt gtggaaagat gacgtatgta tttatgatgt aaatgtcttt 600 cagaatgacc tttgggacta agcttttttt ttttttttcc caccaaaaaa tggtcatgac 660 ctaggaagcc ttgttagtaa aatttaaaaa ggaaaagttg gctgggcatg gtggctcatg 720 cctgtaatct caacactctg ggaggccgag gtgggtgtat caattgaggt cagagttcga 780 gaccagcctg ggtaacatgg tgaaaccccg tctctactaa aaatacaaaa attagctggg 840 catggtggcc tgtgcctgtg atcccagcta ctcgggaagc agagacatga gaattgcttg 900 aacctaggag gtggaggttg cagtgagtgg agattgtgcc actgcacgcc aacctgggtg 960 acagagcgag acttcatctc aaaaataaaa taaaataaaa ataaacagga aaaatctggt 1020 caaatgcccc ttgttcttct tcaacagata catagtgagt tgtgtaaaaa aggagttgga 1080 aaaggaatat gtagattcaa agtgacttaa agaatagaaa aaaaatttgt tttaaaaaat 1140 ggccaagact aaatcatagt gtctagggag gtacacctga ataataaaac tataaagaaa 1200 tacaaaatat ggttactact aagaatagtc tgttgccagt agtacacaga atgagcactc 1260 aaattataac agaagcattt tggtattcat aaatgttctt tttttaaaaa agaacacaat 1320 cgaaattata ggctgtaagt actgatttta attgtagtga atgtgaaagt gttgttaatg 1380 aaaatataaa gaatatttgt taaagtgtgg acctagccag gaatactagg tagaaaaggt 1440 aactctttaa aaacattttt ttaattgtga agttaattta ttgtcacttt gtttgatatt 1500 tattattaga gtccctaggt taattctgtt tttattgctt ttcagaataa ttaagaccta 1560 aatcttctgc cgaattctgt ttggtttcct tatttctttt gccatgttct ttcattccac 1620 aaatgttatt gagcacttcc agtgtaccaa gccttgtgtt tactgctttg atgataaatg 1680 caataaggta atgctgcttt taaggatcct tcaggatagg ctcttgtagc agtaaggact 1740 tagtattttt gctatagaag tgtatggaga gctatctatg gtgcaataac tgtggaaata 1800 cagtttttat tctatttggt tcccatatac attgagtcct cctttggtgg gaatttgatc 1860 aggttggtct cagttgaatc ctggctgcat atgcctcagt aaggaagaag gcctagggga 1920 ctgtggaaag cctggtggtg gtcctggaag gcttgagaat acctggagct ggaagctcct 1980 tgctcattgg tgaccttttt catatgcagc agagctcttg gcattcctag catactacct 2040 tgaaaggact gtgtcttgcc tcctagaaat tctggacttg gtagaatcat ttgtttatgt 2100 tattttaaaa agaaaaaaaa ctctgaaatg tactttttgg aagaaaaatg aacttgtttt 2160 tggacttttc tgtgtgttgt ttctttaatt gaaaattctg tctggagatt gattttcaac 2220 ccccttcctt tccctctagt tttaaattgt aacattgctt tccaagcatt tcaaaaaaaa 2280 aaaaaaaaa 2289 <210> 27 <211> 1694 <212> DNA <213> Human <400> 27 atgccatggc tagtccaggg aaagataact atagaatgaa aagttataag aataaagccc 60 taaatcctca agagatgcgt agacgaagag aagaagaagg aatacagctt agaaaacaaa 120 aaagagaaga acagttgttc aaacgcagaa atgtctattt gcccagaaat gatgaatcta 180 tgcttgaaag tcctatacag gattcagata ttagttccac tgtacccatt ccagaggaag 240 gagttgttac tacagatatg gttcaaatga ttttttctaa taatgctgat caacagctaa 300 cagcaacaca gaaatttaga aagctgcttt ctaaagaacc taatccacca atagatcaag 360 ttatacagaa accaggagtt gtacagagat ttgtgaaatt tcttgaaaga aatgaaaatt 420 gcactttaca atttgaagct gcatgggcat taacaaatat agcatctgga acttttctgc 480 ataccaaggt agtgattgaa actggggctg ttccgatttt tatcaaactt cttaattctg 540 aacatgaaga tgttcaggaa caggctgttt gggcacttgg taatattgct ggtgacaatg 600 cagaatgcag agattttgtt ttgaattgtg aaatacttcc acctctttta gagttattaa 660 caaattcaaa cagactcaca acaacaagaa atgccgtgtg ggccctctca aatttatgta 720 gaggcaaaaa ccctcctcca aactttagta aggtttcacc ttgcttaaat gtcctgtcac 780 gactgttgtt tagcagtgac ccagatgtgt tagcagacgt gtgttgggcc ctttcttatc 840 tttccgatgg acccaatgat aaaattcaag cagtcattga ttctggagtc tgtcgaagat 900 tggtggaact tttgatgcac aatgattata aagttgtatc acctgcatta agggcagttg 960 gtaatattgt gactggtgat gatattcaaa cacaggtaat tttgaattgt tctgcattac 1020 cctgtctctt acatttattg agtagcccaa aggagtcaat tagaaaagaa gcctgctgga 1080 ctgtttctaa catcactgct ggaaatagag ctcagattca ggctgttata gatgcaaata 1140 tttttcctgt tttgattgag attcttcaga aagcagagtt tcgtaccaga aaagaagcag 1200 cttgggctat aactaatgca acatcaggag gtactccaga gcaaataagg tatttggtag 1260 ctttaggctg cattaaacca ctttgtgatc ttttgactgt tatggactcc aaaatagtcc 1320 aagtggcttt aaatggactt gaaaatattt tacgtcttgg agaacaagaa tctaagcaga 1380 atggaatagg cattaatcca tactgtgctc tcattgaaga agcatatggt ctggataaaa 1440 ttgagttttt gcaaagccat gaaaatcagg aaatttacca gaaggcattt gatctgattg 1500 aacattactt tggtgtagaa gaagatgacc ccagcattgt acctcaggtg gatgaaaacc 1560 aacaacagtt tatatttcag cagcaggaag caccaatgga tggatttcaa ctttaactta 1620 ctggaggaaa aaaaatttat ggctaaaaag ggtagcttca ggtaactcct ctttgttgcc 1680 aatgtaagga actg 1694 <210> 28 <211> 4756 <212> DNA <213> Human <400> 28 gcgacgctca cgaacgatca gagctgcggg cgacgcaacg aagcccggag gccgcaggct 60 gcgcgctccc tcgcagcagc cgggcgggca aaagccccca gtcctcggcc cccgcgcaag 120 cgacgccggg aaatgcccac atccgggaaa cctgcagcgg agtgcggcgg cggcgacact 180 gagtggaagg caaaatggcg gcggcggcgg cggtggcctg gtgttaaggg gagagccagg 240 tccttacgac ccctgggacg ggccgcgctg gcccgcggca gcccccccgt tcgtctcccc 300 gctctgcccc accagggata cttggggttg ctgggacgga ctctggccgc ctcagcgtcc 360 gccctcaggc ccgtggccgc tgtccaggag ctctgctctc ccctccagag ttaattattt 420 atattgtaaa gaattttaac agtcctgggg acttccttga aggatcattt tcacttttgc 480 tcagaagaaa gctctggatc tatcaaataa agaagtcctt cgtgtgggct acatatatag 540 atgttttcat gaagaggagt gaaaagccag aaggatatag acaaatgagg cctaagacct 600 ttcctgccag taactatact gtcagtagcc ggcaaatgtt acaagaaatt cgggaatccc 660 ttaggaattt atctaaacca tctgatgctg ctaaggctga gcataacatg agtaaaatgt 720 caaccgaaga tcctcgacaa gtcagaaatc cacccaaatt tgggacgcat cataaagcct 780 tgcaggaaat tcgaaactct ctgcttccat ttgcaaatga aacaaattct tctcggagta 840 cttcagaagt taatccacaa atgcttcaag acttgcaagc tgctggattt gatgaggata 900 tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca 960 ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac 1020 ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct 1080 ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg 1140 tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat 1200 ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac 1260 caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc 1320 caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt 1380 ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag 1440 agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga 1500 gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat 1560 ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga 1620 tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc 1680 tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt 1740 cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata 1800 acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt 1860 ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca 1920 taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta 1980 attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg 2040 tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt 2100 cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt 2160 caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac 2220 cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta 2280 agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg 2340 aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta 2400 ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag 2460 catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc 2520 tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc 2580 aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg 2640 ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg 2700 aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa 2760 agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg 2820 ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt 2880 tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg 2940 gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa 3000 gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc 3060 gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg 3120 attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg 3180 aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag 3240 ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg 3300 cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg 3360 ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa 3420 cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca 3480 gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca 3540 agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg 3600 acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa 3660 attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa 3720 atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat 3780 ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg 3840 aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca 3900 caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt 3960 aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt 4020 atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat 4080 tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa 4140 aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa 4200 agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata 4260 tgctaaataa ttttaaaata caagagtttt tgaaattttt ttgaaagaca gttttagttt 4320 tatcttgctt taaccaaata tgaaacatac cccctatttt acagagctct tttttcccct 4380 cataaccttg tttttggtag aaaataagct agagaaatta agccatcgtg ttggtgagtg 4440 ttcctaggct aatgataatc tgtataattc acatcctgaa actaaggaat acagggttga 4500 aaaaatatta atatgtttgt cagaaggaaa aataatgcat ttattttccc ccccaccccc 4560 cgccccatgg aatatttaat ctatttaatc ttcttgcatt tatttctcaa gaattactgg 4620 ctttaaaaga agccaaagca ctactagctt tttttccata ttggtatttt tgatgctgct 4680 tccaatttta aaagggaaca aagctgccat aaatcgaaat gttcaatact aaaagctaaa 4740 atatttctca ccatcg 4756 <210> 29 <211> 2306 <212> DNA <213> Human <400> 29 ggaggcagga gaatcgcttg aaccctggag gcagaggttg cagtaagccg agatcgcgcc 60 acagcactcc agtctgggcg acaaagcgag actccgtctc aaaaaacaaa aacaaaaaca 120 aaaaacaaac aaaaaaccat aaattcacag ttcagtggca attttaaatg gaaagacacg 180 ccttattcac tatgatgctt ttattgctaa ttcattcagt gaagaggaat tatgcaaggt 240 ttaaaatggc ttgcctgtcc tggtatatcc aaaactctta attcagaaga ttcatctatt 300 tctccaagag aagaagctcg tggtggggct ggaggaggtt caggctcaag atcaaagtcc 360 aatttggtta ctgtagaatc gcttatagaa gataaagtaa ctcaccaaaa cagtaataga 420 aagtctgtat tttaaacagc tttaaaatta aagcaaacaa tttacttttt aagtaaacag 480 aacactactt tcaaaatact acttgggaaa aaagcaagac tcagtacacc tgctataatc 540 agtacgtaag aatgtcccaa taactttgta taagagatgc ttaaaatctc agacacatac 600 ctagctggag gtgctagttg agggatgcgt acatcaacca ctggcactgt agtaggcaca 660 ggagcttgag ggctgaaggt gccagaatga tttactgtag gaatagctct tcttactagc 720 cttccccaag tggcaatatt aatattcatt tgaggagctc tgagaaatgt tttgccttgt 780 tgctttgaaa aaattttctt ttgtctttga agttttggtc ttctttcaat aactggatta 840 aaaaaggtaa cctctgcaaa taaagtaccc tgtggttcca aatagagaca catgccatgc 900 cgttggttgt ctaaaaaatc ttctaacctc agaaaatttt acagcacaca gagaccgcca 960 atcacgccaa taaactgaaa tttccagttc acgtgacctg tccagttcca gtgtaaactt 1020 ctggtcccat gactgattgg aaatgggttt ccagctagtt tggccaacca cagtattatc 1080 gagcttcaaa acagcacaga catcattgga caagtcatcg gtttttagaa gatttcgact 1140 acttccgctt ttacttttac tcgttctgct catgaaagat gatctggttt cacttggact 1200 ccaaccaggc agtgcaactg atgttgcttt tgaccgtcca gggacattct ctaggatatc 1260 ttggcagccc ataagacgaa cttccaaagt acctgttagt gctgctggtt tggatagtgt 1320 actatattga ttttgcgtag atatcatact ttgacgtgga cttagtgttg gtgatgcagc 1380 aacaagtgaa agttcttcaa taataatcct gcttttggga tgattcttgg ggacttcgtt 1440 taatctttgc tctaatgaat actttaaaag gtccaacttc tgacttgatt cattaaatct 1500 tgcttgagct tctgaaagtg cttttctgtc tgttactttt cctgagccaa gtaatttcat 1560 tacattcttt gcaccttctg ctactgcaaa ctctatccta aaatgatgcc ttaattcttc 1620 catccgaagt tcaagaggac ttatcacagg ttttgcatta tcaaaagcca attcattagt 1680 ctggactgcc tgaagaatct gcattcgtat gacttctatt tttgtcttgc tgtcctggag 1740 cagttgctga gctgtaccat ggagtttccg atcctttgaa gatccatttg aatacatctg 1800 tatcatattc tctgcacctt gttttacttt aagttctata tccaattgtt tttgtagggc 1860 cttcaatcta ttggtgctag tagaacaacg agggtcatta tttggagtat ctggagtcct 1920 tgggcaatct gtaatatctt ctggatctga tacaacaata tgtgcattta attcctgcag 1980 cttgtgatgt agttcttcta atttttattt gattttttca aaatgttgtc tacataagcc 2040 aaactttttt tatctgttgt gactttcctc agattttcag ctccttcttt gattttcagt 2100 tctttcctta tttctctctt aattcgatcc ttgatatcat ccaatttctg ctgcaccatt 2160 gtatctgaaa agtctaattt ttgaacagca ctcacattct cagaaaacgg aagacttcgg 2220 gaatccccct gcagttccgt gagcagaatc tccccccgtt cggggttgga cgccattgcg 2280 ctccggtatg gactccgcac ctggac 2306 <210> 30 <211> 1842 <212> DNA <213> Human <400> 30 ccacagtggc gccggcagag caggagtggc tggaggagct gtggttggag caggaggtgg 60 cacggcaggg ctggagggct ccctatgagt ggcggagacg gcccaggagg cgctggagca 120 acagctccca caccgcacca agcggtggct gcaggagctc gcccatcgcc cctgcgctgc 180 tcggaccgcg gccacagccg gactggcggg tacggcggcg acagacggat tggccgagag 240 tcccagtccg cagagtagcc ccggcctcga ggcggtggcg tcccggtcct ctccgtccag 300 gagccaggac aggtgtcgcg cggcggggct ccagggaccg cgcctgaggc cggctgcccg 360 cccgtcccgc cccgccccgc cgcccgccgc ccgccgagcc cagcctcctt gccgtcgggg 420 cgtccccagg ccctgggtcg gccgcggagc cgatgcgcgc ccgctgagcg ccccagctga 480 gcgcccccgg cctgccatga ccgcgctccc cggcccgctc tggctcctgg gcctggcgct 540 atgcgcgctg ggcgggggcg gccccggcct gcgacccccg cccggctgtc cccagcgacg 600 tctgggcgcg cgcgagcgcc gggacgtgca gcgcgagatc ctggcggtgc tcgggctgcc 660 tgggcggccc cggccccgcg cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct 720 cttcatgctg gacctgtacc acgccatggc cggcgacgac gacgaggacg gcgcgcccgc 780 ggagcggcgc ctgggccgcg ccgacctggt catgagcttc gttaacatgg tggagcgaga 840 ccgtgccctg ggccaccagg agccccattg gaaggagttc cgctttgacc tgacccagat 900 cccggctggg gaggcggtca cagctgcgga gttccggatt tacaaggtgc ccagcatcca 960 cctgctcaac aggaccctcc acgtcagcat gttccaggtg gtccaggagc agtccaacag 1020 ggagtctgac ttgttctttt tggatcttca gacgctccga gctggagacg agggctggct 1080 ggtgctggat gtcacagcag ccagtgactg ctggttgctg aagcgtcaca aggacctggg 1140 actccgcctc tatgtggaga ctgaggacgg gcacagcgtg gatcctggcc tggccggcct 1200 gctgggtcaa cgggccccac gctcccaaca gcctttcgtg gtcactttct tcagggccag 1260 tccgagtccc atccgcaccc ctcgggcagt gaggccactg aggaggaggc agccgaagaa 1320 aagcaacgag ctgccgcagg ccaaccgact cccagggatc tttgatgacg tccacggctc 1380 ccacggccgg caggtctgcc gtcggcacga gctctacgtc agcttccagg acctcggctg 1440 gctggactgg gtcatcgctc cccaaggcta ctcggcctat tactgtgagg gggagtgctc 1500 cttcccactg gactcctgca tgaatgccac caaccacgcc atcctgcagt ccctggtgca 1560 cctgatgaag ccaaacgcag tccccaaggc gtgctgtgca cccaccaagc tgagcgccac 1620 ctctgtgctc tactatgaca gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt 1680 ggtcaaggcc tgcggctgcc actgagtcag cccgcccagc cctactgcag ccacccttct 1740 catctggatc gggccctgca gaggcagaaa acccttaaat gctgtcacag ctcaagcagg 1800 agtgtcaggg gccctcactc tctgtgccta cttcctgtca gg 1842 <210> 31 <211> 2524 <212> DNA <213> Human <400> 31 attggctgaa ggcacttccg ttgagcatct agacgtttcc ttggctcttc tggcgccaaa 60 atgtcgttcg tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg 120 gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta 180 gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag 240 atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc 300 actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga 360 ggtgaggctt tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct 420 gatggaaagt gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa 480 ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc 540 acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt 600 ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca 660 gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt 720 ggaaatgctg ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc 780 aaaatgaatg gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc 840 ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat 900 gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc 960 cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag 1020 agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc 1080 aggatgtact tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt 1140 aaatccacaa caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc 1200 caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg 1260 agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct 1320 agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg 1380 gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag 1440 aagagaggac ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa 1500 atggtggaag atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc 1560 attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt 1620 ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg 1680 gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc 1740 taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca 1800 ccgctctttg accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa 1860 gatggtccca aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag 1920 atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc 1980 cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta 2040 gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc 2100 gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag 2160 cagagtgaag tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc 2220 tataaagcct tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc 2280 ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta aatatggtta 2340 tttatgcact gtgggatgtg ttcttctttc tctgtattcc gatacaaagt gttgtatcaa 2400 agtgtgatat acaaagtgta ccaacataag tgttggtagc acttaagact tatacttgcc 2460 ttctgatagt attcctttat acacagtgga ttgattataa ataaatagat gtgtcttaac 2520 ataa 2524 <210> 32 <211> 158980 <212> DNA <213> Human <400> 32 gatcagtcta aagagaattg gcaatatcta cacctgtaaa gtgtaaaatt aggaaaacaa 60 ctcaaaattg ttataaatgt acaataaata ctgctcattc aataacggct aacaacagac 120 tcattgttga aactgcaagt gttgaggatt ttagtaactt gattatgtaa atgagataaa 180 gccttgttta tagatataca aatttaacag gtaattatta atgttttgtt gtatatatga 240 gtgtgctcct gtgtgatgta aaaacagaga catgtttgag aaactatgaa taccttgtac 300 aaacaattta gttgctttat cttagaattt tttgttttac tgtgccttct ttcggctcaa 360 aaggaattat tgcctaagtc agtgattatc tgggcaacag aattaatgtt ctagctacag 420 cattgcacta tttcacagga tctattgatt actttttaaa aatttttctc atctgtcctg 480 ttctcattat tctactatta ttattttagt ttgggcctta tttaacaatt aactaaataa 540 ttacatttgc ccccaaatgg tatccctgcc atctatattc tctctctctc cctctccact 600 catcacctgt ctaccaatat atttattgtc tactactttc catgttcctc attaatttct 660 ggtattagta aactgatacc aaatgttgcc tcccttaaga aactgacagc ctagtccggt 720 ttactactgt tccgtagaac cttgcatctt tcttctttaa aaatctttaa cacctttcag 780 tggcttttag aaaagggttc acatttttca gagcttttga cactctttac cttttgacac 840 aatatattat tattatttgg gggaacagca ggaaccaggg atgattaatt tcctacaatg 900 tgcagggcag ttctatataa caaaattatt tgtcccacat tttacatgac tttcaaatgc 960 cccacaaaat gttcaaagac atgagaatct catctgaact cagagctcaa ctctgttttt 1020 ttataatgta caaagctttg attttattta ttttttggaa aagctttgat tttatttatt 1080 ttttggaatc attttaatat gcactgattt tgatgctaat ttcaacccac ctaattcctt 1140 gcccaactga tagatccatc ttctattttt aaactttagg aagtagaata ggtcagtgaa 1200 gagcattgtg ataaaaaccc agggtattcc cacactgttg ccctctgaac aattttttag 1260 gatgtgagtg tgtgtgtgtg tttgtgcatg tgtgtgtgtg aaggcgactt tcgcttggat 1320 aggatgccac tccataaaac agttagagaa taaaataaaa agagtacagt tggagtcctg 1380 ttcttgctct gcttaccccc attatcttgt gacacacagt acctgttcca aatccccact 1440 cagaattctt aacccagtat ctcaggagta aattctggca ctaaaggggt tctttccttc 1500 tgaggagcta agaaaaacag atggagaaaa tctgacctca agcagatgtg tctctgcccc 1560 tcattctcca aattcttggg agagtgttac tcagtcttac tgcacagtga cattatcaat 1620 ggaactttaa gaaatactaa tgcctaggtc tcattctaat ggcttctgat ttaattgctt 1680 tagggtatgc cctggtgatt ctgaaatggt tctctcacaa cctaggacta gggacttata 1740 atctaaggtg tatgtcctcc aaatgctgat tctacatagg gcagtaaaga gtggaaagtg 1800 aagacttgac ctgtgatttt ggtggtgggg aagagaaagg ctattttggt atttctggct 1860 ctttatctta agagtcatca atcctctact tgcactgtca gacacattgg gctgacacat 1920 tcgaaaatac acattgcctg accgtgtggc tgatactcct agagaagcgg tttctaaatt 1980 ttatagccca ttggaatcac ttggacatct ttaacaaaca ctgatacccg gctcctactc 2040 ctagacatgc cgatttaatt tctatggagt ggcacctggc tttaggattt ttaaaaagtt 2100 gtgcagcttg ttctaatgag cagcaaagat tgggacccag tcccagtgaa aaaaagctcg 2160 tagaacaata caacaggaca tttaaggagc acagccattt caaaacaata ttctgttaaa 2220 aattatagat gtccatatag ctgaaatagt aagacagatt gtgaatttaa aactagggaa 2280 gatatttgaa agattaaaaa aaggagtgga tagccaaatt cataccatat acacatatga 2340 aggtttccag gtcagaagac caacaaagaa tctaaagtaa gacagacatt aggtttttca 2400 acagtaaata ctatatgcaa gaagatgaca aagggatatt ttataagttc tgaaggaaaa 2460 taatttaaaa tatagaattt cccatcaagc caaacagtct tcaaatatgt cagcataagg 2520 aaaggttttg gaagcataga aagtcccaag aggtttgcca tgcagaaact cacatagaca 2580 acagttttgg ataaagtcag aggaaagaaa aatccaagag atgctgcaaa agatatctgt 2640 ataaaaggtg attgaatata ttggcaaagt ttgttcttgt cttggccatt tatttaaagt 2700 caaataaaaa gaggaaaaat attcataata atccacaatt aaaagtctgg aaaaaaaaag 2760 tcatggggat ttttgtggag aactaaggaa cttaagaatt ggccaatttc ttgccttaat 2820 agggagtaac ttttttttta ggagacagca ttaaaaagaa atagaaaagg taaacataaa 2880 caaaaaataa gttaaggttg gagaaacatg tccaagtata ccagtaataa tgattaatgt 2940 aagtagacta gattcaccaa tgtaaagtcc aatattgaaa aactgagtat taaaaaaagc 3000 cagatacata ttgtttaaaa agtatgtgga cttcacttgt gcccaacatg gagcaacaga 3060 aaccagattt acccttatat ctgaaacaac tgagaaactg ggtaaatata ggaaagaaca 3120 gctttcaagg cattggcatc aagcaacaca gaaccgtgat ccctggcaga cagcaaacaa 3180 atgaggtgag ccctctgatt ttactcaaga gaatttccag gccatcagaa ggggaaaccc 3240 aagtggagac cagtggactc cctgagtgaa ggagatgaag ctaagaatac aggaagaaga 3300 atgcagctaa ggttaacatg gcaactcaag caccaaagga gagagagcca cacagagata 3360 aaactctgga caactacaga aaaattgccc tttaatattc agcaaattac tgatcagtgc 3420 atgtatttga aggaaaaaac ctcaatcata attgagggat caattatcaa ctacccaaaa 3480 tgattaaagg aaacaggact cagcactcac ccagaatggg ggaaagtgct tgttccccac 3540 gaggcagact ggtaaaccat acaattcaca gggctttggg taagggatct tgtcttggca 3600 gtggggagta attaacccta gaccaaacat ggtgctgttc ttgcttaata agtcttaaaa 3660 gcaggacacc aaatggtcaa actgtttcaa gtaacttaac tgcatttcaa aaaaactcat 3720 gatactttta gaatacaaaa tattcaacat ccaacaaggt agaattaacg attcctggct 3780 tctaatagca tgaacccagg aggcagagct tgcagtgagc agagattgcg ccactgcact 3840 ccagcctgga caacagagtg agactccatc tcaaaaaaaa aaaaaaaatc agttcatcaa 3900 aattgatcaa tcaatcagaa ctgataaacc aatcagaatg gataaagatg tagtaattac 3960 cagacaagaa cattaaaata cttaaactct acatgctaaa aatagcagaa gaaagattga 4020 acattatatt aagagaactg gaaaatataa gagaaccaaa tagaactttt agggatgaaa 4080 actacagtgt cagagatgaa aaacacacaa agtagtatta acagcagacc aagcactgaa 4140 gaaaaaacca aaagtttagt gaatttatag gcttagcaat ataaattatc caaaatgaaa 4200 gaagtagaaa aaaagattta aaaagaaaat gaaccgtgtg ttagttagct ctgagacaat 4260 ttcaagtttc ctaatgcaca tgtaattgta gtctctgaag gagcaggagc agagaaatgg 4320 ttgaagaaac aatggcctaa aattttccaa atctaatgaa agctgcaaac ccacaagttc 4380 aaaggaaagc aatgaactcg aagtataaga gacataaacc tggccgggca cagtggctca 4440 cacctgtaat cccagcactt tgggaggctg aggggggtgg atcatttgag gtcaggagtt 4500 cgagaccagc ctcacaaaca tggtgaaact ttgtctctac taaaatacaa aaattagctg 4560 gacctggtgg cggtcacctg taatcccagc tactcgggac gctgaggcag gagaatcgct 4620 tgaacccggg aggcggaggt tgcagtgagc caagatcttg ccactgcact ccagcctggg 4680 tgacagagtg agactctatc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaggcctaa 4740 acctacatat aattaacttg cttaaagtaa gtgataaaga gaaaatctta aaagaaatca 4800 gagcaaaaaa aagatatcac aactgagaaa caaagataag gatgctagga gactttgcac 4860 tggcaaatct gagaggatag tagagcagca tcattaaaga attatgggaa aaagaaacgt 4920 gtgcaccagg tgttctatga ttagcaaaaa tatatttcaa aaataatgtg aaaatacaga 4980 tttttcagat tatctagtca caagaatgaa gaaaaccaca aataacactg taggtacata 5040 taaaataatt tttcttctca tcagtatctc ttcaaaagat aattgatggt ttgaaaagtt 5100 ataccatgct tttgggggat ttataacata gccataatta aaatgcatgt catcaattgc 5160 ataaaggtag agagggaaca catggaaata taagagcata agagtgttat atgtgaagtg 5220 gtaaaatatt gctggaagta ggctctaata agatagaaaa aggctcagct aaaacataat 5280 aacaatcaaa ggttggatat aatgtcgact aagaaaagta ggtgtaggta tgttaggacc 5340 agataaaata acattgaatc attagagata aagaggagca caccataatg atataggctt 5400 ttaaaacatg cttatactta atacaagagt ttccaattat atgaagcaaa agtccgcaaa 5460 agtccattaa aatgctatag aaataaactg ataaatccaa catcaaaatg agaaatttta 5520 acacacccct ttaattttta gttggtcaaa gtgaagaaaa taaaagccag tatataaaag 5580 agatgaaaat aaaatcaaca aagatgactt aatcaacaca cgtagaattc tgcataccac 5640 aattgcagaa tacacattgt tctattgaag acacagaaag catataatag gcccttaaaa 5700 agccatgctc tttcacaaga caattaagtt aaaagttggt aacaaaaaca ataaattact 5760 agaaattaag aacatttcaa gaattttcta agcttgtagc ttcggtgcaa ataaagcata 5820 ttttgtttga aattttataa acagtgtttc accattttgg caaatgacat cacaatgtca 5880 cattaactat gttaacagtg catgaattag ggtgaggcaa gtgaggcaac caaggtgcaa 5940 aattcaagga atcaaccacc cgtggaatca tgtaaatacc tgtttacgta tttttgtccc 6000 aggagcttcc taggtttacc ccagttctgg ccctggtatt tgagtcatct caacaagtca 6060 cttgtgttgg tctacacttg tagctgttgc atataaatat gctaaatagg agattcgtgg 6120 ctcattttta acagatttag aacaccatta aattaacagt gaaacagcaa agtcagggat 6180 gctattacat ctcactagta aaggtaactt taaaaatatt tcatattttt taacctacgt 6240 atttttgatt tattctggaa tccattgata aattaatctg ctgtgaaaag agcagagtga 6300 aattatttat ataatttgga gttggcaatc tttttcaaac taactcagat aaatgtcctg 6360 caggataatt ttacaatttc tctacagatt cttattttat agttgggctg tttgtatatt 6420 ttatatttgc tcttaatcca tcctttcttc cccatcttca atagatatac ttcaagattt 6480 cagcaccaaa gcctaatata tgctttgaca agtagcaggc tttccagaga tgagatatgc 6540 cttctgtcat gatatgttac tgtctcattc catgcagtga cataaggaaa tattttgact 6600 ttataaagct cagctcattt gtgagggtat tatatttcat tttccgcccc tatgtcactt 6660 tgtcatttgt cttgacttat cacccctact tcaattaagg ttatgtccca ctttctttta 6720 tcacagaagt aatactagtc tgttttactt attgcatcaa ttctttttat tgctgctgta 6780 acaaatattc acaaacttgg cttgaaagag caaacattta tgacctgata gttctacagt 6840 tgagaagtct gacacaggtc tcactgggct aaaatcaagg ttttgacagg acaatgttcc 6900 tttctagagg ctctagggat gaatctgttt cctggtgttt cctctagagg ctgccagcat 6960 gccttaatgc gtggcctcct ccatccacaa agccagcaaa ggtaagcggt gcccttctct 7020 catctgcagc actctcacct ggcttctctc tccgcatttc tttctctggc tctgggtctc 7080 tcttccactt ttaatgatcc tcgtgattac atggggccca cccagacaat ccagaaaaat 7140 ctttcttttt aaggtcagcc aattaacaat cttaattcta cctgtgcaac cttaaattct 7200 ctttggcagg taacataata tattcacatg ttccaaggat tcagatgtgg atattttttg 7260 gtaggggcat tattctgcct gtaatatatt ttttcgaaca ccagttgttg ttctagtgtt 7320 catgcccatg tttgttgttt cattttccta ggcttctaca aaatgagttc acctcacttg 7380 tcacaaattg tatcttattc atttcctgta ggcacatgca tttgaaactt ttatacatct 7440 tctggtgtat acaagtcctt acatgatgaa atgtaaatta ttttaaatta ttttcctatt 7500 atggctctaa aattgtatgg ttggggcatc ctccctccct cctttccccc cttccttgct 7560 tcctcctttg aaattatgtg tgttggtagg ttgcattaat catcagtttt atttcagggt 7620 cataaaagga gtgtaacaaa ataagtataa taaaaaagga atgttggata tgttatgact 7680 gagaggcacc ttagcagaag ccaaaagttg actccttgga ctataagaga agcctcttca 7740 aggaaaattg tagtgctctg tccataaaga actgtgcaaa cactacctac ccccacctcg 7800 aaatactttg gatattcagg cagagccaga gctactgtca gtggaaatat tgaccttagt 7860 atgtcattta attacctgag ctctatcaag aaccttgtag acctgtgagc agaatatgaa 7920 atagagctta cctcctatag tttgataaga gctccacaga gccacagtgg aaaattaagc 7980 aaattcctag acaatttcaa taaaaatggt ctatttttaa agttattcta aataaaaatt 8040 aaaaatttgt gttaacctta ttttggttac taaatgataa tgaacatacc ttttcaaaat 8100 taaaataaag tttacattct tcttgtgggg acacttttaa tttctgctta gatgatttat 8160 aatggaattc atcaccaaaa gataatttaa ttatatgacg gtagtttaca tataaattag 8220 aaagttttag gctgggcaca gtggctcatg cctgtaatcc cagctctttg ggaggccaag 8280 gtgggtggat catttgaggt caggagtttg agatcagcct ggccaacatg atgaaacccc 8340 gcctctacta aaaatacaaa aattagccgg gtgtggtggc atgtgcctgt agtcccagct 8400 acttgaaggg aggctgaggc aggagaatca cttgagcaca ggaggtggag gctgcagtga 8460 gccgaaatca caccactacg ctccaacctg ggtgacaggg ggagactctt tctcaaaaaa 8520 aaaaaaaaga aagttttagg tttaaatttt tttttttctt cttggtgaga cggagtctct 8580 ctctaacgcc caggctggag tgcagtggca cgatctcggc tcactgcaag ctccgcctcc 8640 cgggttcacg ccattctcct gcctcagcct cccaagcagc tgggactaca ggcgccggcc 8700 accactccca gctaattttt tgtactttta gtagagaggg ggtttcaccg tgttaccatg 8760 gtctcgatct cctgacttcg tgatccacct gccttggcct ccgaaagtgc tgggattaca 8820 ggcgtgagcc accacgcctg gccttaattt tttttttaat tctttacatt ttccaatgga 8880 gtaattatat ccctgagtta caagtcaaat gcgagcctcc atcagatttc ttggctccct 8940 tcctaaagac aatagagcaa ctcattactc tgcttcagaa tctttctccc aacctttagg 9000 cttctctagc tatgtagtga tgggaggaaa ggtggtggta gggtggggtt gggcacaaat 9060 tcctattcct ttcatgactg ttttacagtt gcttccttgt agggacatgc cacagaaaga 9120 agacactaca ggatccagaa atacttaaat aagataattt gtggaaatct tatcccttaa 9180 atatcttcag ggagaagtat ccttagcaac ttcttctttc tataggcaaa tcatggctgg 9240 gtaggtggtg gtcttctgct tccaagaaac cggcaatcaa caactcaagt tgcctcactt 9300 ctcatataca agtcccagca agagcctaga tgaattcact aatgcacttc atcctcctgc 9360 cctcttcctg gttcaggcaa taataatcat agatcgccat tgtcaattct tttttgttag 9420 acatgatgct ttttaacatt atttcatcta atgctcacag aatctctatg tggttagaaa 9480 tactattact ttacaaatga aagaacgcaa aataattgag ggatgtagat aactctctcg 9540 agataatgca gtaaacaaag ggtgatatca ttttgctgtg tccccaccca aatctcatct 9600 tgaattgtag ctcccataat tccacgtgtt gtaggaggga cctggtagga gataattaga 9660 tcctgggggt ggtttcccct atactgttct tgtggtagtg aataagtctt aggagacctg 9720 attgttttat aggggttttc ctcttttgct tggctctcat tttctctctt gtctgctgcc 9780 atgtaagatg tgcctttcac ctttggccat gattgtgagg tctttccagc catgtggaac 9840 tgtgcatcca ttaagcctct ttttctttat aaattaccct gtctcgggta tgcctttatc 9900 agcaatgtga aaatggacta atataaatgg cagggcccat aaatgaactc tattctgttt 9960 aacaccagtg tgtatcgttc attcattcaa caaaacaatt cagttactta atatgtgcca 10020 agcagtgagt taggtattga aaaagcaatg attaaaaaga cagaaggtac ctttctcctg 10080 ggaggttaaa ttttactgaa ggaaatagag ggaaccaagg aaataaaatt aagtagttac 10140 aatatgtaat aattttgatg aagaaatcac atagggatcc ccaggagggc agaaaggtat 10200 ttcaagcaga aagttcaaga aaggtctctc tgagtaatga ccatttaagc taagtcttta 10260 ggaagacaaa gggtgtggcc tggaaaggct ggtgggggca gaaagagcat tccagagatg 10320 cacaccagcc agtgcagagg atgactcaca cgcagtttgg tgaagactga aggggtcata 10380 aaagtaaagc attttttgga gtgtaatttg gcaatagcca tccacatttt aagtacattt 10440 aaattttctt tgggtgcagc aatttctttt cttgtgggct ttaaaataag tgttgcatat 10500 gtgaactaag ccacacaatc aggtagacat tacactttcc taagggacag agagacatgg 10560 gatctcaggt ttttcttgct gttttctttt tttaatgttt tcttcctctt cttattttaa 10620 tcttctgggc tataagttat aatgctcctt ttagactttt tttttcctac cctgcaggca 10680 gtcacctgat agagaggttt cctggaatag taataggaaa ataatgcaca gcaaagctga 10740 cacaccacat gccgagctgt actgaaggca caatcataac ttttaataac gaaagtttct 10800 tttggtaaaa taatatcttt ccagctgtcc taacagatac taatgtgaaa tgctcccttg 10860 ggacaggacg gtggagagaa gtcacccccg ttccagaggg gcatgccctt ggctcagaac 10920 ctcagagcac taacataatg tagtactaag attgcagtga caccagtaaa acctgctctg 10980 taggactgca acaggctaca ttttttttat ttgtgctttt gttttcctgt aaatcacttt 11040 tgagtttctg tttctcaagt ctggaagcag caggtgtgta attttggcag aacttttccc 11100 agccattatc tagtggttta ttgtttattt agagtgtggg ggtgagttat aataaagaga 11160 ttggccctgt gggttaagac tgggcacatt tctatttaca gtcctaccag gtcttcacat 11220 tctaggcaaa atgaaaggct aagccagtta tccagatagt tcaggccaaa aggtaaacac 11280 aaagagagga tgatttagtg ctgtcccacc tccggcttac gcttctgagg taacaaccac 11340 agggttctgc tttggtttgg caatggaaat ctgagttctc ctagctgtga cttgtgttag 11400 gaacgtagac tctgtccagc tcagtaggct gtgacataga aaatacatga agttaacttg 11460 ggcatagaga tagacatgat ccaattcccg gttcaaaact tatcccctat tgccttgttt 11520 cttttccttt tatatgctct tacatctcta gtgaagtttg ccatcagtat atttagttgt 11580 attaaaaatt ctccaggttc agttaatgcg gtcattttgg gtagactgtg acatacattt 11640 gcatggattt ggtctccctc cctccctccc tcccttcttg ccccgcttca ttgctctctt 11700 atttcttttc ttcctttctt actcccttcc ctcatcactt ccttcctttc ttccacattt 11760 atttaatgtc tataaccaga acccatgcta catatttgag aaacaaagtc aaacaaagca 11820 tacatttatt ttctaataaa ctaacagtgt agttgttggg gaaaaagaaa agtaaatgaa 11880 aaattataat attttggtta aaatatacat tggaagctgc tggaaaagaa ttcatgaaca 11940 caacttagtt gtttttagtt ttacaggaag tgaacctgat atacaattat tggtggtcta 12000 gaaatacaga tgaactggat aaaataattt tgaaaaagag gtttaatctt tctcactgaa 12060 aatccattac agtatggaac atatttattt cttctttgaa ttatatacat ttcctaacac 12120 ataatagatg cttaattaaa atgtttgaaa gaaaggagat gtaaatgtca caattttaaa 12180 aagtaatgat ttggctgggc atagtggctc gtgcctgtaa tctcagcact ttgggaggct 12240 gagatgcaag gatcgcttga gcccaggaat ttgggaccag cctgggcaac aaagtgagac 12300 ctcgtgtcta caaaaataaa agaataaaaa taaaaagtac ccaggcacag tggcccattc 12360 ctgtagtccc aggtactcag gaaactgagg caggaggatt gctctagcct cggaattgga 12420 ggctgtggta agctatgatc atgccactgc aatccagcct gggtgacaga gcaaggccca 12480 atctttaaaa aaaaaaaaaa aaagaacaga aaaaaaaaga aatgattctt ttttgtagag 12540 agtatttaga aaacatttta tgccatgctt ttctgtatta gtgaggaaaa aactgaatat 12600 aatttacctt ttctttgaga actcaatcat cagtatgaac aatgattact taagtgaact 12660 ttaggtgttc aggcagagga agatgtaggg tatagggcca gtgggtagca acacgagcaa 12720 gtgcatcaca tattctttat tgaaatgatc tcatttgctg aatgcttgct tctagtttat 12780 ttttattgga tagtttcctt tctcacatat gtggaagaaa accaatgtat tgcttggccc 12840 ctagggaagt gtaatgtggc tattctttcc caatgtaaat catggaataa aaatccacag 12900 ccttctctca aattattttc ttaccctcca gaaaaattcc tttctctcct tgtcatttga 12960 tttctcaata acattcagat cattatctct ttttccaacc tgtcactatt aacatatcaa 13020 cttcaatata ttttctatat atttacacta tcatttattg aacaaatatt tattgaacac 13080 ctgctatgta tcagacattg ttctaagagt tgaaggtgca tcattaagca aaagtcagaa 13140 tccctaactt cacagagttt acaatacagt acatgtaact gaagtgtctc tctcactatc 13200 aagaatttgt gttcgtgtaa ttgggagggt tctttttctc tttctctttc tctctttctc 13260 gtttccttct tttcctttct ttctttcttt ctttgttttt ctttgtttct ctcttttttt 13320 ttttttgatg gagttttgct cttgttgccc aggctggagt gcaatggcac catcttggct 13380 cactgcaacc tccaccttcc aggttcaagt gattctcctg cctcagcctc ctgagtagct 13440 gggattacag gtgcctgcca ccatgcgcag ctaacttttg tatttttagt agagacatgg 13500 tttcaccatg ttggtcaggc tggtcttgaa ttcctgacct caggcgatcc gcctgccttg 13560 gcctccgaaa atgctgggat tacaggcgtg agccaccgtg cccggcccca gggctttttc 13620 aaagtgtatt tcataataac aagaatgcct attcattaaa ggttttataa gattttacag 13680 ttgacaatgc tcttttagag aatacattct cattggaatt tcacagtaac ttttaagata 13740 cataggatag gcgttattat tgtttttttg tactgtgcag atgcagaact tgggtttaga 13800 cagagtaaat tacttctcaa gatcccagag gtgtaagtag caaatacttg agtttagaat 13860 atttaaaaat tccaaaactg ccttagtact tttaaatttg gaaaatattt ttatatttat 13920 tattttattt gttcttcaaa atgatctgtg tggtaattac tgattcctct ctaatcttcg 13980 tgcccgatga tgtggaattg ttgcattatc tgcccagatt tatctagctg gtaatggtag 14040 aactgaaaat ccaactatgt tcattgaaaa aatcaactgt ggaagctgaa cacaaatatt 14100 ttctttaatc tttctatatt cttataggca aatggaattt taaaaattta ttataaatat 14160 aatagagatt tttaaatgct ttataaatta atttcccatg aagttaattt ttctcataac 14220 attatatatt ctaaataaca cccaggtata cagtttgaac aatgaagtga cagtggcagg 14280 cagtaaaatc ataaaacaat tacctgacac attctgcttt tcagagtatt ttctacaatt 14340 ttcttaagtc aacctgtcat tcagacaagg tttaaaaaag tacatttcag cttccaaaat 14400 aaggttaaaa caactagaaa aacaaaacaa aacagagctc tagcacccct ccttgtatgt 14460 ataatacata tcttgtaaat acagagctgg aaatgtacat tatttttgac agatagagct 14520 ttcaatagtg agggttttat tacataaaag acagcaggaa tggtatatgc aaaagccgtt 14580 aaggtctccc ttttcttctt aaactcagca gtttgtgatt attactattt ggcaagcagg 14640 agtaaattgg accacaattt caacagcctc atagaagtat tccaggagac agtgttgata 14700 aatgagtcct agaatgccat ataattttcc tgcagtttca ttgtttgatg acttactttt 14760 catggataca ctctgccctc aggtttcatg tcctgctgcc aaatgtgaaa gctgtttgtc 14820 agaaatcaat gggttcaagt ggcccatcaa aagcttctgc ctttttgttg ataggaaaca 14880 ctttgtatag gaatctgctt tctggagaac tcattgctat cccttttgta tatacctgaa 14940 ccttgtcctg gctattatta tggtttcctt tgccagggga ttccccagtg aagggtgctc 15000 tgcctagtac tgcttgggtt actctcaaga tgacaacccc tccaatacag caatgactgc 15060 aaagctccta aggacaatag gattcagagt gtcttcttcc accaaaagct gagctaaata 15120 tagcctaaat atagcttttt gtattttgtt ctagggggtc attgatgtat ttacaataag 15180 ggatagatag gaaattttca tatattgtga atctattatg tagcaggcac tgaggtgctt 15240 tccacatgct atcttcttaa attgtcatac gaaaactctc tataaattat gtattatccc 15300 cattttacag atgagcaatc tgctactcaa gaaagatagt atttgctgaa aggcaaataa 15360 cagaggtggg atttcaaatt cagttttatc ttactcccaa gatcatgctc tttctactta 15420 gcatttggtt aaccgggttt aatttgcact aagaccaaat gacagcaaaa gaatttctct 15480 tctgataggc aaactgacaa atcaaatcta tgcttttgaa aagtctgtta cttcccatga 15540 ctctgttttt tgtttgtttt ctattggtga gaatagagta catccagtca aaagtaagtc 15600 tggttaaggt gggattttga aagttgggtg gaagttaagt gtctgactag ttctgtccac 15660 tctttgtccc aaatctccat tgtgataggt aggatctcct cagtccaggt gtctgtatgt 15720 gacaataggt tagaaagatt cttgtacttg aggctttatg aagttgacca aaagacatta 15780 agaatgacta agtgggccag gtgtggtggc tcacacctgt aatcctggta ctttcagagg 15840 tcaaggtagg cggatcgctt gaggctagga gtttgagacc agcctggcca acatgaagaa 15900 atcctttctc tactaaaaaa tacaaaaatt agtcaggcgt ggtggcacat acctgtattc 15960 ccagctactc gggaggctga ggcatgagaa tcacttgaac ccgggaggtg gaggttgcag 16020 tgagctgaga ttgcaccaca gcactccaat ctgggtaaaa gagtgaggct ccatctaaaa 16080 aaaaaaaaag aacgactaac tgcacttagg aatggggact acattcattt tttctgtata 16140 gatactggag gtcttactag ggggttgtgg gattagtttc catatgtaat tgttctaaat 16200 gctttgcaac ctcacagttt tgagtctttt gatccctttg gtggtttatc caggctttac 16260 tacctggaac tgctgatact tggttccaga actcttatta gcaagatctt ggttagtcct 16320 tgcatctaca aatagctcaa gttcacctta agtagaaagc ttatcaatag atttctgtgg 16380 agactgcgga tccctccaat acacttgttg cttgatttat ttactagctc tcctctcttc 16440 ttggctttat ctcttactgt ttaagtagga gtttgttttc tcttttgttt gttttatttt 16500 tggttaaagc agcagagaac ccagctcaaa ttggcttaaa aagtgaaagt gattaaagtt 16560 ttcgtggtat tgtgggcttc agcttttgat cagtgaagaa tctggctcta tttctctgct 16620 attcttttgg ctctggtttt gcagttgtag ctttgcccta agtctggctt gtcctatggt 16680 tataaaacgg ctgccagcaa cttctgaagt gacccgtttc tccattcagg tttatagaaa 16740 agaaagagag aattgcttct caagccattg aattgaagtt ctaaattttt ctctgaagga 16800 atcaatcatg gatgcttggg gtaaatgaga ttaacctgat ttattctaat caaggtgcac 16860 ccctggaaga ggtcaactct tccaacaaat gcacggtttc tatacaatga agagtgacaa 16920 agacttgttt ggaggtaatc aaaatgccca ccacatttca ctgaacctaa atattaaatt 16980 tgtctttact tttttgttgt ctgttttaca actagcaatg gagcagagaa agttggagga 17040 aggttattgg gatctttttg aagagcaaat cacattctca ttggtaacca tgatgaaaac 17100 atattttctt ccttgtgtgg gtctgagaca gtgtcataaa ctgctttcag caatagttag 17160 tatggtctaa ccgagtggtt ctcaatcagt tctaatcagt ggctccttct cccaggccag 17220 cagcatcagc atctcctgga aatgtttaga aatgcaaata ttgaaacaga aactctgggg 17280 atggggcaaa tctgagtttt aatgaacact gccattgatt ctgatcatgc tgaagtttag 17340 aaaccactgg tttgatgctt atttgcacta ttatactgtg gtttacatat gggcttgaca 17400 ggtccattta ctttcattta cttgctattt gagattttgt ctggccagac aactgagcct 17460 cagataaatt attttcttac taaattctgg taaataccaa taaaaccttg aatacaacca 17520 acataggaca gtcagttctg ctataatgat ttttaaaatg ggaatttgtt tcaatgcaat 17580 taatatattg ggaaacaaat ttagcataag gcaaattttg catttatttg tgcactactt 17640 catctgctag accaactagg tgaatgtagg aaccatacac agctgagctg agtctcatag 17700 gaacacataa aacacacaca cacctctcaa ggacaatcag tggcccagac ccatgcacat 17760 ctactattac aacttcttgt ccatttccac cacttcactg ttattaatac aagctgcaag 17820 tcttccacaa actaacttca ggtggttttc aagataaagt gccatattgc ttgcagtatt 17880 tatgtatttt ttaatcattt aatgaatgta aaactatgct accatttatt agctgcttct 17940 ttttaaaaat gttccactga caaatgtttt gagtattatg ccccgaggcc tatgattttt 18000 attgtgttct tttgcattgc acagagaatt ttagcaatcc ctatgttgca ctaaagcaga 18060 attgagacta atttgagcaa aacttagcaa cttataactg ttacaatcct tatttcaggg 18120 caaacttttc attttataat cataattatt ttgtttcctc ttgagtagca cacacacaca 18180 cacacacaaa tctaaggtgt tcactatcac agaataatag cctttaaaat gtttaccagt 18240 tttcatattg atatattttg tttgactctg tcattccggg ctttaagtac taaaatatat 18300 tagtcttttt cagaaaacat tccaagaaaa aagttgaatt cctacctagt ttcctctctc 18360 tttgataacc tattgtcata gtaatataca aatacctgaa aattgcccag attattcttt 18420 tcttcttgga acacagattt gttgataagt gccaaaggat tttttacaaa aacatgagaa 18480 gtttgacatc acagtaagat ttaaaaggaa aggctgttta ttgttattat catcattgct 18540 actactattt ccgttagtat atatttcttt gtcttatttg tccttttcca aaagattttt 18600 gttcttatat ttttaattag ctctttaaag aaatcaagaa ctgcttgttg attatagaca 18660 tccttattgt ataaagaggg agaagttctt tggtaattag ctgtgtatag gttctgttca 18720 aacaattggc tcaagtgagg ttgtacagaa agaactcttg tattttctta tttttcagta 18780 tattctccac tccatcacac ctctttttcc aaagatgcag tgcaaagaaa gtataatctc 18840 tggagtaatt aaagctcagt gaggaaatga tatcacctga tggccctatg aagcattcag 18900 caataaaagg tgagttgccc aaaatgcatt taccctgaac aggaatacaa tgaaactacc 18960 aagttttatc tttataatga ttcgtggctt attattttgt tgtttgtata tgttctgttt 19020 cccacatcag tgttgtctta cattattatc tgtcttaact tagactctgt tttctaaatt 19080 gctctgtgca attaaatgct ttgtgatcat aataaaaagc atcatgataa cttttagact 19140 agaggtttcc atacaaagct gtatcccatg gagagcagct actggcactg aacaatggct 19200 agagatactc tacataggga aggggctgac aattattcag tttaaatcaa tcacttgtgc 19260 atatatctcg atagaacact aggctagttc gttgtgtgtg tgtgtgtgcg tgtgtgtgtg 19320 tgcatgtgtg tgtgtgtgta tgtatgtaat tcactgctta ctctataaca gagagaatat 19380 caattaaatt gggccatata ggaagatcaa ttaatatatt tgttaattga ggaacttttg 19440 atggccttgt tgatccccta tggtttgatc tttaaatctg tagtgtttat tagactcact 19500 acagactctc tgtaaatcgt aagacattta catctataaa tgcattttaa aacatcaaat 19560 tttaaatttt gcagcactaa aatgtgtcag acaatattct caattaactt gcattaatat 19620 ttgcttagtg tctgataaaa tgtgtagtgt aggacaaaat gtcctacata atcaacaaaa 19680 cactcttcca aaattaaaca taatatttgt taagatggtc actgtttttt taaaaaaaga 19740 gcactactac acagatcaag ccaatgagcc ccagtcagtt gacagaagta catatttggg 19800 actccttctc taaatttttt ataaaaatac ctgaagaaga tgaatagtca tttgctttct 19860 tattttaaaa gatctgtccc cccaactaac tttttaatct tctacttgtt accaaatacg 19920 ataaaaagga gagggggaaa aaagcagaca ccagtttcat tcgtgaatgt aaactttggt 19980 tttttggttt tcttttcttt ttttttttga gacagggtct cactctgtca cctaagccgg 20040 agtgcagtgg aacgatctca gctcactcac tgcaacctcc acctcccagc tcaagccatc 20100 ctcttacctc aacctcccaa gtaattggga ttacaggcgc agccaccacg cctggctttt 20160 tttagtagag agagggtcca tgttgcccaa gctgacctct aactcctggg ctcaggtgat 20220 ccacccacct cagcctcccg aagtgctggg attacacatt gcacctggct gaacttctga 20280 aatgaatgaa gtgctcctaa atgaatgaac atcttgaatg gcaaattaag tttcaagtga 20340 catataagcc aacaagtatt tctaaatttc taaaataaat ttccaaattc gaagtcattc 20400 tttcttttct ttcttttttt ttttttgttg ttgttgtttg tttgtttttt tgtgtgtgtg 20460 tttttgccgg tctgttttta atcgtggcag cgcctcacac acacattcag ggttcagatc 20520 ttgttcaaag ctgcgatgtc gacactctgc acatgctcct caaacttggt gatctcctcc 20580 tccagcaagt ctgtccccac tttgtcgtcc tccaccacac actgaatctg catcttccgg 20640 ataccatagc ccacggacgc cagcttggag gccccgctca ctagcccatc cagctggata 20700 gagcgcacac atgcctccag ctgggtcatg tccgtcttat tgtcccaagg cttgatgtcc 20760 agcaggatgg aggacttggc caccagcgag ggattcttgg ccttcttggc gtacagccgc 20820 agccgctcct cccgcagccg ccttgcctcc ttgtcttcct ccttattgtc gctgccaaca 20880 gatcaatgtc atcgtcctcg ttatcctctg cttcttggcc ggggtcgtag taaggggggc 20940 gaggggaggg gcgctccact tggcgcatgg gagacacgtg ctgtgtctgc gggactgtgg 21000 accatggcca ggcgagctct tctctcttct ccggcatgtt cagccaggcc tccaggttgg 21060 agaccgcctg ctgcagctcc tgcaccacgc cgcgcaggct ctggttctcc acttccaggc 21120 tggcgatctg gaggacgagc tcgctgtggt cttccctggg gccgagctct ggcgggaggc 21180 gctggccaca ggcccattca tctgcttgta gaatttcctt tctgtatctt catatttgaa 21240 tttgtcgagc cagatcttct catgtgctag gaattttgta gccatttttc tgacgcctgc 21300 caagaatgcg gctaccagaa atgaggaatc ggtagacgca ggacgcctaa gggcgaagtt 21360 gctctttcat aatgtacaaa acccttaagt cttcaacaga aagcaccttt tttatttaaa 21420 agaaaatcct gcagtttgca aataaaagtt tgtatttcag agagttggtg aggaaataat 21480 ccattaaaga ctgcctttat aaacataaac tgctgggaat aaagtaagat ttttaaaaga 21540 caatgaaaac attctgacat ctcaacagga gttagcctga tgaatccatc tcataccaga 21600 agtctttgtt ttctatttct ggctccttca ggagctcaag gttttacctt ggacaggtca 21660 tttcatctgt cagagccttg tttctcttac atcaaaggaa gaggcttgtc tgtaaaatct 21720 ttaaagttct tctttttctc aaatataaaa ttatcattca gatactcttg gtataatatt 21780 taaaaattat ttaaatattt aaagaaaaat gttttgaata tttttctata tactgagctg 21840 ctatgttgag aaatcccaga ggtattattt cagtgtacta ttgctctgat gaccagctac 21900 cactggagag gggtactatt tcttccttaa aacttgtata ttcccctcaa atactgatgg 21960 aggaaagagt acatgaatct ttatagtaaa agatagacaa ttagatataa ttgatcttaa 22020 tagatctgta gataatatgg accattatct acatatcatt tgttaaatta atgccttcta 22080 gcactcagct aaactaattg tatcgtgtgt gtgtatttct taagcaaagt ttgtttcata 22140 gatcagtgcc cctgggctag acaggaaaat gtcaaagctc ttaaaccagt ccaccaaagt 22200 atgtcaacta aaagcctcag aactagtagt atttctcgtt aggttttcag ttgcagggta 22260 gagaaagaaa gcaaaatcac aaggcaggta tttttctaca gcagtttgat ttagcaaatg 22320 ttgaacaaat aaaccattaa ctaaataaaa tattgcatat atatatatat atatatatat 22380 gtatattgtg tttattttca tgttgtctga catcctgaca actaaaggga aaataatata 22440 gaagtatttc tacattattt tgtgtctctg agtttgtgtc tctgagtttc ctgggcaaac 22500 tttgtgtctc tgagtttcct gggcctgaaa taattggcag ggtgaatctg aaatgcagac 22560 acagaaagtc acccttggtt tgatgccctt ttttttttcc ttttcatgtt tatattttgg 22620 tgcatttccc cccgatatca aatattacct tggtactaaa aaaatcaaga agggaaaatg 22680 caggcaggag aacgaggaga atcaccttgt tacttctctc ccatatatga ttgggctcat 22740 gtgattggtg cattagactt tgtagtgtca tttcactcct ttctctgtag acatcaatac 22800 taacaaatga actgcaaaat cctaaagtgt gaggataaac accaattatt tatgtatgca 22860 catcatttgt atggatttct aactattgat cttcaggtaa atgtctagac agaagtagat 22920 ttaaatgtat aggtagttgt gctatatttt tacatttata gtaattaaca tctagaaaag 22980 caagaaggaa gagacaaaat atcagttatt attttgccta cttgcctctg caaaaaagaa 23040 gaaataaaag gattgccttc tatctacctg agacagacat ttaaactata gtgaattcag 23100 aatctttagg cattctcctc aaagtttcct tcagtgaaaa ttgatttgaa tcaaaaattt 23160 atgttaaaaa aaatggcagg gccaatgttc ctagcagagt tatctgaatg atttgctagg 23220 tcaagcaatc ggtcaactat tttcctctag atcataggat tagcatatca ggccagatac 23280 ttatcctgtg caatgttgag cacagttatt tttggaatct aagagatcat atgatttgac 23340 actcctaaag gagaccttct aagactttac ttccaaaaaa ctgactggat attatagtaa 23400 aatataattc ctatactaaa atacagctgt aaaaaccaaa atgcagcttg aatacattta 23460 gagggagtct tcagtgcttt gtccattaga taaaaagatt gcaaattaaa agtactcaaa 23520 aattgcagtt gacattcaga aactcattag cttctttctt tcccaaaatc accatagcaa 23580 ttagtctaca ctttaattgg tcaaaattat tcatcattaa aacactgatt tctaaaagac 23640 catttttttt cccctctgtc ttggacttaa attttttagg aatttaaatc ttctttctct 23700 accagtttct gaaatgatta agcacatttg cattttatct gtctagagaa gatattcctt 23760 cccttgaact ctctcattct ggcctcttct gcttggtcaa ctgtctgtgg aaattctgtg 23820 ctgatcatct atagattaca tgctaatcta tatttcctaa gaaaaatagg aaaaatatgt 23880 acacagggtt cagtttacat ttagaaatct caggatcttc tgtcaattct tacccaattt 23940 tcatgataat ccctacattt ttttcttaat ttaacttatc cagtttaaga tgttgcttcc 24000 ttattaaaat atttatcacc ttaaaattgt ccactacaat ttaatatata gaagctttta 24060 tattccttcc ttccttcctt cacatgtcca gtcaattagt catttattca ttcagtatct 24120 tccagtgcca gcactgtgct agaaacatgg aatgaaaaga ggaaagaggt gtgttctatg 24180 atctaaaaat gttcctaaag gtcaggtaaa caaataagtg catttaaatg ttaagagaac 24240 aaagacaaga gaatatgcag gacatgccgg aggcccaatg gaaggtagga attttcccat 24300 ctgggaggca ggtggtgaac cagaaggttt ataggtgaag acgatgcttg aactgtgttc 24360 acaggtgctt tttgccagat agtctaacag attaaggtgc tctccctata gagggagaac 24420 cagagggctg gaaactgaag gatgaattca gggaaaatga caagtagtgc agtctggcta 24480 aagcagaaag gcatatcagt ggggcaggga ccagttaatg gataataaca agacagagag 24540 tttggatttc aaaccacaaa atatggtcaa gggaaaaatc agcagagtta agccagaaca 24600 ataatatgat atatattttt tcatttagac agaatgcact ggatatttaa agaaatagaa 24660 ataaaacatt tcagaatcta gcttttgctt ctcattgaca aagtctttac taagatggaa 24720 taaaaatgga agcatggaac agagagagag aagttgtatt tcttcatggg atgacaagaa 24780 gggtagatga ggctcgccca agtacagtga tgtttacacc taattgatca caaccagtta 24840 cagatttctt agttctttct ctactcccat tgcttcactt gactagactt agaaatgaaa 24900 aaaagaaaag aaaaagggtg gattatagag cttaagatct gtgctttggt ccccatattt 24960 ccaatccttg tcaccaatgc ttggtaaata tgtgggtata taaaaaatta tatttaatta 25020 attaattaac tatttttttg agatggaatt tcgctctcat tgcccaggct agagtgcagt 25080 agtgcgatct cagctcactg caacctccac ctcccgggtt caagtgattc tcctgcctca 25140 gccttccaag tagctgggat tacaggcatc cgccaccatg cccagctaag tttttgtatt 25200 tttagtagag acggggcttc accatgttgc ccaggctggt cttgaacttc tgacctcagg 25260 tgatacaccc gcctcagcct cccaatgtgc tgggattaca ggtgtgagcc acaatgcccg 25320 gcccttaatt atgttttttt aaagctatat gacagtaacc aaaactatat gattgaggaa 25380 atatttgtag aaatgatata tatgacaaca gtagcaaaaa ggacaagggt aaataaacag 25440 aagtcatatt tttcaaaatt cttgcacttt attagaagta ttataaaatt aattgtaagt 25500 agattgtggt acttaataat gaatgttgta aaccctacag catacactaa aaataatgta 25560 aaaatgtata tttaaaaagc caatagagga attcaaagga atattttata acaacatcag 25620 ttaaccttaa agaagacaga aaataaggaa gacaggaaca aaaatacagg tgagacaaac 25680 agaaaagaca tagcaagtta tagttgggtc ttgattttca aaatctgggc taagaatttc 25740 catcttttaa tggggagaag taatctattt ataacaaata taattgtcaa ttaagttggg 25800 cttaagtcct attaaaatat atagattttt agcctggata aaaatgtatg gccccattat 25860 atcctgtcca taagagaaaa actttttgtt aagaaaatac agattgattg aagcaaaata 25920 atggaaaaaa ttataccatg cattcaataa acataggcaa tatggagtgc ctatattaat 25980 accagaaaaa aatagacttc aatgtaaaga gtattatcag atatgaagaa gaatattaca 26040 taataataaa ctgctgattc attaaggaaa tataacaatt atatatgtgg gaaggtggag 26100 caagatggca gaatagaagg ctctaccgat tgtccccact accctgcaag gacaccaaat 26160 taacacctat ctacacagaa aaaaatatct tcagaagaat caaaaatcag gtgagcaact 26220 cagtacctgg ttttaacttt attgctgaat gaggcactga agaaatagaa aaaaacagtc 26280 ctgaatccca atgccttcct ccctacccac agaaactgag tgtggtgtgg aaagcatctc 26340 tcagtgctga gggaggagaa tacagcaatt atgaggcatt gaactcagta ctgttctttt 26400 agagcagaaa ggaaaatcac atcaaactta gctgatgtcc acccacaaag ggagcattta 26460 aaccagcccc agccagaggg gaattgctga tcccaacagc tgaaacttga gttcctgcaa 26520 acctccacac cgagggatac aatactctat gtctccaagt aaacttgaaa ggcagtctag 26580 gccataagga ctgcaacttt taggcaagtc ctagtgctgg actaggccta gaatagtgga 26640 ctgggctggt gcagtacata ctgagacacc agctggggca gggctgcaca gggtagaggt 26700 aatgctagca ctccctgagc cagacaccac cacctctccc ttaagcctag gctgcacaag 26760 tctctccaaa agagacccct ttcttccact tgaaggagag gagaggacag aatggggagg 26820 actttgtctt gcaacttagg tattagctca gccacagcag gatagagcaa tggtcagagt 26880 caagaagccc ttgttctagg ccctaggtcc cagacatttc tagacatacc ttgggccaga 26940 agggaaccca ctgccttaaa ggaaaggacc cagtcctggt agcattcatt acttgctaac 27000 tgaagagtct ttgggccagg aatgaccatt agtgatacac aggtgctatg tcttgggcct 27060 tgggtgagtc tctgagactt tctgacttca ggtgaaactc atcatcttac tagcttggat 27120 ggctatgggt caaaactccc tctgcttgag aaaagcagag ggaaaagtaa agtcttgcac 27180 cttaggtaca agcactgcca ctggggggta gagcaccaag tggtctcttg gggtccctga 27240 ttctagcact tgactcttgg atggcatttc tgcacctgcc ctgggccaca gaggtgctca 27300 ctgccctgaa ggataagtcc caggcaaggc agcattcacc acaagctgac ttagagccct 27360 tgggttttaa gggaatattg gagatagtct ggcagtactc cttgtggcct ggggtggtgg 27420 tggcaatggg gtgaagctcc tctacctttg gaaaggggag gaaagtgtgg gaaggactgc 27480 atcttgtggt ttgagtgcca gctcagccac agtacaatag aacaccagaa gacttctaag 27540 atttttgact ctagtctctg aactaccaga ctgtagctct ggacccacgt ggggcctggg 27600 ggaccttgcc accctgaaga aaaggacaca ggcctggttg gctttgccac tggctgattg 27660 ggtagcccca gggccttgag tgaacatagg cagtagccag ggagtgacta cagcaggcct 27720 tgggcgaggc ccggtgctgc gctaacttta gatctgaccc agtgcagtca tagtagtggt 27780 ggacacagag gtgcttgtgt tactccaaat ttaggtgact tggaacagag agactttgtt 27840 catttggaag aaattaagga aagagaacaa gagtctctgc ctggtaatcc agagaatgct 27900 cctggatctt atccaagacc atcaaggcag tacttctatg agtctgcaag aaccacagtg 27960 ttactgggct tgaagtgccc ctaaatcaga cacagcttag atcataacac ctaagccctt 28020 tgaaatatct ggaaagcctt ctgaagaagg acaggtacaa atatgcccag acagtgaaga 28080 ctacaataaa tactgagttc ttcaatgccc agacaccaaa gaacatctga cagcatcaac 28140 actatccagg aaaatatgac ctcaccaaat gaactaaata aagcaccagg gaccaatcct 28200 ggagaaacag agctatgtga cctttcagaa acagcattca aaatagctgt atagaggaaa 28260 ttaaaaagaa attcacaata agacagagaa ggaattcaga attctatcag ataaatttaa 28320 caaagagaat gaaataatta aaaagaatca agcagaaatt ctgaagctga aaaatgcagt 28380 tggcatactg aagaatacat cagagtcttt taatagcaga tgtgatcgag cagaagaaag 28440 aattagtgag cttgaagaca gggtattcaa aaatcaacag tcagaggaga taaaagaaaa 28500 aaagaataaa aaacaatgaa gcatgcttac aggatttaga aaatagcttc aaaaggataa 28560 atctaagagt tattggcctt aaagaggagg tagacaaaga gataggggta gaaattttat 28620 tcaaaggaat aattacagag agttcccaaa cctagaaaaa tatataaata tccaagtaca 28680 caaaggttat agaacaccaa gcagatttaa tccaaagact acctcaaggc atttaataat 28740 gaaactctca aaggtcaagg ataaagaaag aaccctaaaa gcagcaagaa aaaaagaaac 28800 aaataacata tgatggagct ccaataagtc tggcagcaga cttttcagtg gaaattttcc 28860 aggagagagt ggtgtgccat atttaaagtg ctgaaggaaa aaaaacttgt accctagaat 28920 actatatctg gcgaaaatgt tcttcaaaca cgaaggagaa ataaatactt tctcagacaa 28980 acaaaacccg agggacttca tcaataccag acttgtccta caagaagtgc taaaaggagt 29040 acttcaatca aaagaagaca tcagtgatca ataagtaatc atctgaaggt ataacactca 29100 ctggtattaa taagtataca gaaaatcaga atattttaac gctgtaactg tggtgtgtaa 29160 gctactctta tcctaagtaa aaagactcaa tgaagaacca atcaaaaata ataactacgg 29220 caacttccca agacatagtc agtacaataa tatataaata gaaacaacaa aaagtttaaa 29280 agcagggtgg gcaatgaagt taaggcatag attttttatt tgttttcttc ttgcttgttt 29340 ctttgtttat gcaaacagtg gtaaattgtt atcagcttaa aataatgggt tataagatag 29400 catttgcaag cctcatggtt acctcaagcc aaaaaacata caatggagat gcaaaaaata 29460 aaaagcaaga aaccaagtca taacaccaaa gaaaatcacc ttcactaaag gaaggtggga 29520 aggaatgaaa gaaggaagac aagatcacaa aacaaccaga aaacaattaa caaaatggta 29580 ggagtaggtc cttacttatc agtaataaca ttgaatgtaa atggacttaa tgctccaatc 29640 aaaagacata gactggctga atggaagaaa caagacccat tggtcttttg cctccaagaa 29700 acacacatca cgtataaaaa catagactca aaataaaggg atggaaaaag atattccatg 29760 ttgatggaag ccataaaaaa gtaggagtca ttatacatat atcagacaaa atagatttca 29820 agaccaaaac tttgagaaga gacaaagaag atcactatat aatgatgaag gggtcaattc 29880 agcaagaaaa tataataatt taaaatatat atatgcaacc aacactggag cacccagata 29940 tataaggtaa atattagagc taaagagaga tatagaaccc atatacaata atagctggag 30000 acttcaacac cccactttca gcattggact tatcttctag acagaaattc aacaaagaaa 30060 catcagactt aatctgcact atagactaaa tgtatctagt ggatatttat agaacatgta 30120 atgcaatggc tgcagaatac acattctttt cctcagcaca tggattattc tcaaggatag 30180 accatgtgtt acatcacaaa agaagtctta aaatattaaa aaattgaaat aatatcaagc 30240 atcttctctg accataatgg aacaaaacta gaaattaata aaaagaagaa tttgggaaac 30300 tatactaata caaggaaatt aagcaatatg ctcctgaatg accagtgggt caataaagaa 30360 attaagaagg aaatttaaaa atgtcttgaa ataaattata atagaaacac aacataccat 30420 aacctatgag acacagcaaa agcagtacta agaggcaagt ttattgctat aagtgcctac 30480 atcaaaaaag aggaaaagct tcaaaaaaca atctaataat gcatcctaaa gaactagaga 30540 agcaagagca aaccaaaccc aaaattagtg gaaaaagaga aataataaag atcagagcag 30600 aaataaatga aattgaaatg aaaaaaaaat tcaaaggatc aatgaaacaa gaagttggtt 30660 ttttaaaaag ttaaacaaaa ttggcaagcc tttagtcaga ctaagaaaaa aaggagagaa 30720 gatctaaata aataaaatca gaattgaaaa agtagacatt acaactgata ctccagaaat 30780 tcaaaggatc attagtggct acaatgagca actatatgcc cataaatttg aagatttaga 30840 agaaatggac aaattcctag acacattcaa cctagcaaga ttgaaccatg aagaaatcca 30900 aaacctgaac agaccaataa caagtaatga aattaaagct gtaataaaaa ttttcccagt 30960 aaagagaagc ctcagacctg atggcttcat tactgaattc tatcaaacat ttaaagaact 31020 aataccaatt ctactcatac tcttattaat attctgaaaa atataggagg agggaccact 31080 tccaaattca ttctacaagg tcagtggtta ccctgacacc aaaatcagac aaaagcacat 31140 taaaaaaaag gaaactacag gtcaatatat ctgatgaata ttgatacaaa aatcctcaac 31200 aaaatactag caaacagaat tcaacaatac ataagaaaga tcattcatta tgtccaagtg 31260 agatttatcc ctgagatgca agaatggttc aacatatgca aaccaatcaa tatgatacat 31320 catatcaaca aatgaaggat aaaaaccata tgatcatttc aattgatgct gaaaaagcat 31380 ttaataaaat taaacatcac tgcatgataa aaactctaaa aaaaaaaact gggaatggaa 31440 ggaacatatg tcaacataat aaaagctatg tacatcagac ccacagctag tatcacactg 31500 aatggggaaa aactgaaaac ctttcttcta agatctggaa catgacaagg atgcccaatg 31560 tcaccactgt tactcaacat agtattggaa gtcctagcta gagcaatcag acaagagaaa 31620 gatataaaag gcatccaaat gggaaaggaa gaagtcaaat tattcttgtt tgaaatgata 31680 tgatcttata tttggaaaaa cctacagact ccacaagaaa actattaaaa ctgataagca 31740 aattcagtga tattgcagga tacaaaatca acaaacaaaa ataagtagca tttccatata 31800 taacagtgaa caatgtgaaa aagaaataaa aatgtaaccc catttgcaat agccacacat 31860 ataattaaat aactaggagt taattgagga agtgaaaggt ctctgaaaac tatgaaatgc 31920 tgataaaaga aatcgaagag aacacaaaaa atggaaaaat atttcacatt ggtggattag 31980 aagaattaat attgttaaaa tggccacgct atccaaatca gtctacagat taaatgcaat 32040 ccctatcaaa atactaatga cattctttac agaaatagaa aaaacaatcc taaaatttat 32100 atggaaccac agaacatgca gaatagccaa atctatccta agcaaaaaga ataaaactgg 32160 aggaatcaca ttgcctgact tcaaattatg ctatagagct atagtaatca aaacagcatg 32220 gtgctggcat aagaacagac acataaacca atggaacagg atagagaacc cagaaacaaa 32280 tccactcacc tacagtgaac tcatttttga caaaagtgtc aataacttac cctggggaaa 32340 ggaccgtgtc ttcaataaat ggtgctggga aagctagatc ttcacaggca gaaaattgaa 32400 actagacctc tatctctcac catatacaaa aatcaagtca atatggatta aacacttaaa 32460 tttaagacct caaactctga aagtactaca ggaaaacttt ggggaaaata tccaggacgt 32520 tggtctgggc aaaaatgtct tgaccaatac cccagaagca taggtaacca aagcaaaacg 32580 ggacaaatgg aatgacatca agttaaaaaa cttccacaca gctaagcata caatcaagaa 32640 agtgaagaaa caacccatgg aatgagagaa actatttgca cacttcccat ctgacaaagg 32700 attaacaacc agaatatata aggagctcaa acaactctac aggaaaaaaa tctaataatt 32760 caatttaaaa aatggtcaaa agatttgtat agacatttct caaatgaaga cataccaatg 32820 gcaaacaggc gtataaaaaa tgctcaacat cattgatcat cagagaaatg caaatcaaaa 32880 ctgcagtgag acatcatctc accccagtta aaatggcttt tatccaaaag acaggcaata 32940 acgaatgctg acgaggatgt ggagaaaagg gaacccttgt acactgttgg tgggaatgta 33000 aattaataca accactatag aggtcagttt ggaggttcct caaaaaaaaa aaaaaaaaaa 33060 atctgagctg ccatatcatc tggtaatccc actgctgagt acatagccaa aagaaaggat 33120 atcagtatac caaagatatt tacactcctg tgtttattgc agaactgttt acaataagta 33180 agatttggaa gcaacctaag tgtccaccaa caaatgaatg gataaagaaa atgtggtaca 33240 tatagacatt agagtattat tcagccataa aaagaatgag attcagtcat ttgtaacaac 33300 atggatacaa ctggagatca ttatgttaag tgaaatgaac caggcataga aagacaaaca 33360 tcacgttttc actaatttgt gggatataaa atcaaaacaa ctgaacttat taacatagag 33420 agtagaagaa tggttaccag aggctgggat gagtggtgca agcctgggaa aggaggtggg 33480 gatgaataat gggtataaaa attgtagtta gaatgaataa gacctgctat ttgatagcac 33540 aacagtgtga ctatagtcag tactaactta attgtgcatt ttaaaataaa aacagtgtaa 33600 ctgcatcatt tgtaactcaa aggataaatg cttcagggaa tggataacct attctccatg 33660 atgtgctaat ttcacgtttc atgcctgtat caaaacatct tctgtgctcc ataaatatgt 33720 acacctacta tgtacccaca acttttttaa aaaattaaaa tatatatgtg tatgtactaa 33780 taacagagct tcaaattcaa tgaaaaaaaa aacacaaaat ttgacagaac cgaaaaaaga 33840 aataggcaat tccaataatt atatcacttt tctctcatta atgtagaaca actaggcaaa 33900 ggaatcagta actgtatgga atatcagaac aaaaatatca gatactttca gttaactaac 33960 atcaacagaa tacatccaat aactgcagaa tatacattct ttttaagtga acatagaaca 34020 ttcaccaatg tagctgatgt gctaaacatg tctaaataaa ttttaaaacc ttgcagtatt 34080 gctgactata atctctaacc acaatggatg taaattagaa aaaaatacga tgtctaggaa 34140 agtctggaat atttgaaaat taaataacca actctaaata atattaatat atgggccaaa 34200 ggtgaaatca caagaaatat taaacaacat tttgaagtga atgataatga aagtacaaca 34260 tataagaatt tgagaaatgg aatggcaaat tcatttgctt tcatgaggtg gtaactaata 34320 tagaattgcc ccctttctgt aaataattag aaaactggac caaatatgta aaacagttat 34380 ttttaaagat tggcctatag ataacaaagg actattattt tcttaacaaa tgagttaagc 34440 cctaccagct agaggaaaaa caggtatgta aggatgatca cagatttctc ttcatagttc 34500 aacactaact atgtgttgtc tgcatgagac acatttttaa tataatgacc cagaaatact 34560 taaaaataaa agaatgggaa tatatgtacc atgcatttaa aaactattat gatataccaa 34620 ggaggctgca gcaccacttc tgtggtattc ctgccaaaag tatgtatctt gaatctaatc 34680 atggggaaac atcagacaac ccaaggtgag ggaaacccca caaaatgact gacctgtcct 34740 ctgcaatagt gtcaaggtta taaaagtcaa ggaaaaaccg aagagttgtt ccagatgaag 34800 aaaactaaag agaccttcaa ggggtgattc tgaactggag cttttaaata taagtcttgt 34860 tggaacaacg ggtcaaactt gaataggatt caaagaggtg gcctaaagag ttaaaagact 34920 taagtgatag tattgcatca gtgttaatct tctgattttg atggctgcat ttcattatcg 34980 tgaaagaatg ttaaatgtct ttgttcatag gaaatacaca ctaaagtagt cagggtgttg 35040 aggctttagg ttgataattt attctcagat agttcaggaa aaattctttc tgctgtttgt 35100 gcaacttttg tgtacgttgg aaaattttta tacaaaaatc aacttcaaaa ttgaccatat 35160 aaatgaatac cattgaaata tcatttaaat tatcagtagt aacattagat gctagagata 35220 gtggagtaat gccttcaaaa ttctcggggc aactgctgtt catcactgaa tcatacgcag 35280 atcacctttc aatcaagtgt gagggtaaaa cagcaacatt ttcagatata tgagaactca 35340 gagtccccat tccctctatc aaaaactgga gaatcaacct tatgcaaatg aggcaataaa 35400 aaatgcacac agtggtggag agaaacaata aaatgacagt gttctgttgg cctaagaagt 35460 taaaaagagg ggccaaaaag tagcagaatg ggagagtgtg cagagatatg tctggaaatt 35520 actattttcc aatgtagata ttttaaaata ggtgcatgca tttctttact gattatttaa 35580 aaattatatt taatatgaat ttaaagaagt gagtggggaa atgaagacgg caagtaaagc 35640 ctaatttttt taacagcaaa taaaggagaa agcagagaag gtagttaaaa aggaatctat 35700 gtttgagaga ctgtttttcc tgctaaatta agagaaataa gcatggtact gtgatctgaa 35760 ggaaagccag aaactgggtg accaaataaa atgcactaga aaagagtgct tttttactaa 35820 ggttggtaga aaggaggtga tgtaccaagt agatagaaat aatttgtagt ctagtgtgct 35880 gcagagagcc tcacttttct ttatacaaag gcatattcta agaaaaaaaa aatagggcat 35940 agatggataa agaggattgc aaagctttgc aaaaagttga aataacatcc atgcctcata 36000 gttgagggag ctaaaagagg aacacacaga agaattgccc agcagcatgg atggtcctgc 36060 tgaggaggtg aacatgaatt tttaacagca ttagccacac atttgtatag tgctttttaa 36120 agcttttatt ctaatgtttt tggcagcctg ggtgtagcta ctaaatttag atttgggatt 36180 tgcccagtct tgcaaacaag taataaccca gggtatggcg taaactaaaa agaaaaagaa 36240 gagaaactat gcaagtatgt caggcagaat tcaactggag gtcaaaattt gctgaaatag 36300 caggtagagt gggattaaag gagcaaaaag aggggattct atgaagttgt ggtccatgaa 36360 agactgagag gaggagggga agaaattcag aattgaaatt gactactcaa aaggcttgct 36420 cgtgaaaaaa actgccaata aaaaatcaag catccttgtg tacaaagaag aaaatcaaag 36480 agagatgcct agggaccttc agttgttttt aggaagttaa gctggcctag agtttcttgc 36540 tgagtatcct tgcattcgtg gggatgacat ttctgggaca aagcaaactt ccaccacatc 36600 aaactacctg tggatgataa accaactatg atgaagttgg ccttttccag gtttctacct 36660 tggcaccaat ttaacacttg catcctttct agcaaggttg ttttttattt atgtttttta 36720 tttcctctgc atctcagtga tagttgtctt ggcacacagt cccagctgca gacagctttt 36780 atttttaggt ttccctattc agaaagagta gtccctgttt aggcatttca ctgtcattct 36840 aagctttcca ctgagctaca accctgcagc tttcttcaaa ttcaagtcac tggggagggc 36900 ttttgaaatg ctcaaagaac gagacaacat tttgtacaaa ggggaaaaag caaccataaa 36960 gatattccaa aaccaagtag ataccatgaa aacgaatgga aaagagaaga cagtgacagg 37020 aaccaaaagg acaaaagaca atatgttgaa tctgtaataa gccagccaga agccccaagg 37080 acaatggtag gaacctacag atagaggtct gcacataggg aaataaattc ttacttcgtg 37140 attcccaaaa gcaccaccca agttactaga ggtgacaaaa atacttcctc ttattaaaat 37200 aaggaagtta ttttgggacc acattattag tgaactggtt agttttagag agctcttcta 37260 gaaactcatt gaggtataga ttttcaaagt agttaagtac attatttgag taaaataaca 37320 ttatgttcaa cctaacttac aaaaggaata gtataattaa acagacttgt gcctggaact 37380 gaaaatatac tcagttaagc attgccatat tttataaagg atgttagaat ccctttaccc 37440 tgtatttagt aatcctagct gtgatgcaag atagattaat agataagcca caaagtaatt 37500 gtaatcaaac ataaaggtac aatttaggaa atgggtaatg tacctatagg tgcctaatcc 37560 aatatatact tcatatgatg cccaaatatg ccacattttt ggtctgttag aggagcatga 37620 aactagtgat ggtcaggaaa tgattcagaa agcaagtcct aaggcagttg caaagctgta 37680 gaaggaaagt cctggaaagc tttaatgttt tgggcttgca aatgggtctc tttgtcctca 37740 aatgttttaa gaataatttt tcagtcataa tttgtaaaaa ccaatggcat ttttgttgaa 37800 aatattttgg cctcttgagg tggacttgca gaaaatactg caacagcact tttgtacccc 37860 cactaaccat ttcgatgaac tcagctgtat catctcctgc cctcacccac tgtttcactc 37920 ctggttactg ccctctgttc ttagcatata tgataccctg ccatggctca ttcgttctca 37980 gcaaggggac aaggaactca agaactggca gcacgagagc aagttgcctc aggccagggg 38040 tcagacccgg ctataggtct tgccttgtct cctctccact ttctctattt ctttggctct 38100 cctgacaatt tctcatagct tccctgtttg agcacacatt ttgcttttcc ccttgcattt 38160 ctattgatca tccagaagct gtttgctggg gcctttgcaa ctcccagctt gcaatattta 38220 tgtccattct cttgatacct atgtgtatcc atttccctga cattttaaaa tgtgtttctc 38280 ctcagtttta gctcttctcc tgactactac tttgccctgt ccctagatat cctgccataa 38340 ttaatgttga atgaaagaat ctaatcaacc aagactggaa attcatacag actttgaaat 38400 ggggacaaaa tcttacattt gtttctagtg tgtccccata gatttgacta tcacactttg 38460 gggcatcagt ggcattaagt gacaaattac ttctgggagt tgtaggatga ttctatgtca 38520 agctctccac tcagatccaa tgagtcacta gttcctactt atgaacaggt attaacttgc 38580 ttcatttgca aaccccagca agaattttgg tcacaagcca cagttgccat aagaactggc 38640 tttggaataa gttaggcttt ggttcctatg ccagctctcc catgtcataa ctttgatcag 38700 gatagcaata ataataatat tttttctccc aagacttacc atagagtttg gtacatagaa 38760 agtacttaac tactatgatg aggcataaaa atgtttaatt aatcaccgag atttaaactg 38820 acttttagag gaactttctt agcaggtacc tggttcccca aagtttctca tgcccatgac 38880 acgcactata accttagcaa aggttatcag gatcttctgt tgactgtgct gttctttctg 38940 cacttttggc ttcttggaaa cactgtccct cccaacagtc catgctgaga gtttccaact 39000 gggtaatcac atctgtctag tcagatgcta actttctgct ccgcagaggt atgtccctca 39060 aagttcatac ctgaggaatc atttggaaag attccttcct tcaatatctc tggctgagtc 39120 atgcatacct cctcatcaaa gacaaataga aaacaaggtc aataggaaag cggtgctcac 39180 ctatcttact gtctgtacct tttcctatta tgactagcct cataatcttt aggttagaat 39240 gacttgcact aacctgttcc tagagtccct tccttgtccc ttgtggcact tgccagttgt 39300 gattgcaact ggtggtttta agcatgttac cacttcaaaa ctccaagctt tatgaaaacc 39360 aagaagatgt atgtaccatt tgactatttt tatatctccc atttctagcc caggggttgg 39420 cattatcaca tagcagttaa gagcttgtga tctggagcca gcctgcgtgg ttcagcttaa 39480 aactcaactc catattattt atgtgaattt aggcaagtca ctgaaattac tcctacttca 39540 gtttactttc ctaaaaacag gtattttcat aatagtgttt acctcttagg agagattaaa 39600 taagtcaata tgcataagca cttaggacaa tgcttggcac agagcaagta actattaaaa 39660 taggtactta gtaaatattt gctggattag caaatgccac aataggtcca gtcatcagca 39720 ttttgcagac atcatttaat caacccgaat agtccagtgg ctctagagtc tcttaatttc 39780 ttttttcatg attttttttc atttactgcc tctcaggctt tattgcattt gtgtcaaatc 39840 cacttgtcta aacatttaaa aaagcaaaac agtgttacat agttttaaaa accattataa 39900 tttgactcta tgagtttcaa aaacttcata tacaagtgct taattgtctc attcgaggtt 39960 ttacattgct gatgaaatcc actcatttaa gaggtaggta gtaatgcagt gtgtggggtg 40020 taaagtaaaa tgctaggggt gtgtgtgtgt aggtatgttt gtttatatgt gtgcttgtgt 40080 atatttttat gtgtgtatgt taggggtagc tggctgtgcc aaaggtgaat aagatgaagt 40140 tcctgctcta tagaatcttg aaatttaata aaagagataa ccatgcaaac aactaactaa 40200 atcacaaggc acaatcctct gtgagcctgt gagtatctgc atcctgctct gggaaagtgt 40260 aataatctct ttttgtgtct acgattgtac ccgggctggc atctgagtta gatcataggc 40320 tcctaacatt tcactttatc agttcgtaca atgccccaca tctctgtgag ctaaaaaaac 40380 atgttgctat cagcacaatg tgagaagaat ggtttttttt ccccgaaggg acaaaagtag 40440 tgccataaag ctatagaata ggcaagtctc tcagtaaaat gagtttccct aaaaggattt 40500 cctaaggaac atcttaaggt atttaaataa acaaacaaat aagacaactg agtagagttt 40560 aagtctgtgc cttttcctta ttctctagtc ctggttcttt tgacgtaaag tgaaacattt 40620 ttggggttat ttatttccac ccccactctg tcataatata aagagaattc tcagagggga 40680 gactatagaa gtctgtcagc agctgactct tttctggcag gaagactatt ttataaaaaa 40740 aagaagaaat ggatttcctc tccttgtagt tcaatatttt cttcctctac acattggtta 40800 aattcctcca tcctatttcc ttgaaaatgt cagggttggg ttgccccaat ctcagacagc 40860 tctcttcatt atgattatca gtgttaatgc catgtcatta atcctcacga gtatatggag 40920 gcctcacact gaatgaatgg ggaaggtcac catggaaaca tctgtctcca tagatgactc 40980 acggcaaccc ccataactgc tgaaccacat cctgtctccc aaatgcactg gatgaagcca 41040 caaatttggc atttcctaca ggaccatatt ctttttaaaa gctattaaaa atctatgcca 41100 gggaagcatt tttcagactc atggcaataa tactctttgc aatgtgttta agtgggtgat 41160 gctatgcaat tagttgttaa caccttttaa taaatgcaca cagtaaacat tacctgtggt 41220 ttttcagctc ccggtttctt tgcagtgctg tcatctctgg agacaggcgc tggcagagag 41280 aaaagtgccc atgtagaaaa taagcaaaac acctgcattc tcacatttca gaaatgatcc 41340 tccttagggg ttagtgtggt ctatcaactt gcatcacagt gaagtggagg ggaataaaat 41400 ggtctttgct ggatttattt ttttggctgc ctcaatgaaa aaagcaagca agataactca 41460 tgtagaaaaa ttacatttga ggactgcaga cttctcactt agccttatca tggaacggca 41520 ggatatcaac atttcctaga tggaaaatta ggtctatgtt gggagatatc aggcttaagt 41580 aaaatcacat gacaactact gtgtatatcc cagtcacctc ggcacagcta cgctgagcag 41640 tctttctagg gttgctatgt tcagagttgg ctgtaactat acacaccgta agcccagttg 41700 gaaaagcaaa caagggagtg aaaaagggaa cagactattt cccaggctgt acacatttgc 41760 tgaatcttca caaaggcagg ttgtcatttc ttgtttattt cttgaatcct agatggaaac 41820 ctggaacttg agtgataata atagtagacc tttgctaact gtacatatat tagctcattt 41880 gtttctgtaa atgatcatat aatgtgggta gtattcttta cttcatttga cagattaaga 41940 gactgaggca tggaaaaatt aagtgatgtt accatggtca ccaagctctt aagtagctga 42000 ggcgggacat gaacccaggc atctggcatc cagtttattt cctttaactt taagccacat 42060 atttacctct tgtagagtca tatttattcg ttttctctcc tcttgtttcc tctcctcttt 42120 ctctccctct ctctttctta ccatttttct actactcttt cacacctgcc cccaatcttt 42180 cccctcaagc ccacacccac ttcctacttc tctcctctct cctctctctc tccctctcta 42240 ttgctggaag tgatgagccc catctgggtc caccagctgg ccccagacag gggattttgg 42300 cctctcccaa attaaatcat acttgtaaag caggaaaagc tactccctgc ttccagatct 42360 ccccttccca ctgaccctcc cttgtccctc tgtcgccttc cttcttttgc ataggcttcc 42420 agttctcttg tactcttctc ccacagtttt ctcaggaaag aatgggttgt cttaaagtca 42480 tctgatatgg tttggctctg tgtccccacc cagatctcaa cttcaattgt aatctccagg 42540 tgttgaggga gagggttgat tggatcatgg gagtggtttc ccccatgctg ttcttgtgat 42600 agtaagtgag ttctcacgag atctggtggt tttataagac agtttcccta cccttgcttg 42660 cttctctctc ctgccatgtg aagaaggttc ttgcttcccc ttgtcttctg ccatgattgt 42720 aagtttcctg aggcctcccg agccatgtgg aactgtgagt caattaaacc tcttttgttt 42780 ataaattatc agtcttaggt agtagcttta tagtagtgtg agaatggact aatgcattat 42840 catatagtaa attcagtctc ttcatttaca ttaaagttcc cactttatga acatttgctt 42900 tttaaaaaaa actttgttat tgaagtacag tttaccatat aaatggtgtc gtggactgaa 42960 ctctgtccca aaattcatat gttgatgcct taactcacta tgtgactata tttggagata 43020 gggcctttaa aaaggtaatt aaagttaatt aaggcctata gggtgggacc ttaatcgaag 43080 atgactggta cccttataag aaaaggaagt gacacaggga catgtataaa taaagaaaag 43140 gccatgtgag gacacagtga gaattgttga catgttgatc ttggaattcc agcttccaga 43200 attgtaagaa aattaatttg ttgttgaagc cacctagtct atgacatttt gttattccaa 43260 cgctagcagg ttaatacata tggggaaata cacaaaaata ctcaaatctt aagtattcag 43320 cttgatggat ttctatatat tcataaaccc atgaaatcac tgcagatcaa gaaacagaac 43380 atttccagta ccccagaaac ctccctcctg ccccttccca ctcacgttag cagtctgtgc 43440 ccgattttca gatctgcttc cctgcagaga gggttcactt aggcccttct ctctcatgtg 43500 gaagagcttt acttctgcaa gtgcccctgt gcctgggtct ggatatgaga gtcaattttg 43560 ggagtcaggg ttggcggggc cacttggcca aagagctaag gcaacatttt ccaagctgtt 43620 ttcacaagtg ataaagatga cacaataatc ttcatctgat ttctgcatct atttctcaat 43680 tgtttctgaa ctagggaggg gaaaagggta tcattatctc cttgatacct aacattttgg 43740 tggttggctg tgtttaagtt tggaattttt aaaaataacc tatttttatt ataaaacatt 43800 tcaaacattc aaaacatttc acacattcaa aaatgtatat actaatataa tgaactacca 43860 cctgatttca ataaataaag acgatttact atatttgcct ttgaaaaaca ttttaaacta 43920 ctttagtaaa taagagtttc ttctattatt cttgaaacct aaaggctctg ggtcttttga 43980 acaaataatg actctaataa tcaaataaaa atcacaacat gacacaaagc tctcacaatt 44040 aattctactt tttatctaat gcactttcca tcatgttgca taccatctgt taactaatga 44100 aatgccctaa ggctcaaatt gataaataca aaaatctccc tttctttgat atgtgattga 44160 ggattccacg ctgatttgga ttagatcttt gatgaagtag tagaggcaac tgaaagttta 44220 agcaaatttg gggttgtcct acatcactaa catcatcctc tgggcaggaa tgggtcttgg 44280 gatccattta ctttcccttc tctccaacca catatatagg aagagcacct ggtggatcac 44340 accttgatga tcaggcagct acaccaaatg gttacagaaa atatgaatag gtttgagagg 44400 ggaagagcgt cataaattct tcaaagaatt gctatatggg tttagaggtg acaaagctat 44460 tactggtgaa gagtcatcac ggaaagtcct gagttctgaa tgaaaatgct caaaaaatga 44520 gaaaactggg acttcaaaga taggcataaa caaatggaag catattacaa gtgaaccagg 44580 cagaacatca aattcaggcc agggttagtt attgttttgg aggaattatc tagggcagtg 44640 aatgtgaaca gctatgaatg attttgaaca taaagaactc attgacttca tgtgctcact 44700 ccagagatct aaatagcatg tttgaaaaac aaatggccaa gtcgggagag cgggagagcg 44760 ggagagcggg agagcgggag agcgggagag cgggagagcg ggagagcggg agagcgggag 44820 agcgggagag cgggagagcg ggagagcggg agagcgggag agcgggagag cgggagagcg 44880 ggagagcggg aactgaaagt ggtgagaacc ctacattagg ttgagaagaa acaagacata 44940 ttaagaaaca agttaaactg ttaatgggaa catgtcttga ttttcttgtg tgattccttc 45000 aattctttag aattatcaat atgaatgata aaccacatgc atccagtaat aaaaaatccc 45060 agtctacagc tgctgaggaa attcaaaacc catttgggtg tttgagtgag atacttctgc 45120 cagcattcag cagtagcttt gcaaggactt acattagggt cacatcctta gtctcaatcc 45180 agccctcata tccacctact cttaggagaa ggaggaactt acctgattgg tgggtttagg 45240 attagttaga tataatcaat gcagcccatt cctctctctt cttcttgagt ctgtgtgctg 45300 ggagaaggga tgtattgtgt gctctttacc acttgatacg accctgctac agtgtggtag 45360 gtctgccact ttctggctgt acttatggac agaagggaag gggtaaattt gttcatttca 45420 gaggtgaagt cttagcaagt tcgcactgcc agtgtctaag ccatagtctc caatcacttt 45480 tgttagtaat aaaagtgtat tttgttagta atataccttt tgtcactttt gttagtaata 45540 aaggtatatt ttgatgttat cccaaagttg aacatggagg aaagatatgt ttttcaacaa 45600 tactttcagc agtattctgc tctatttcct aaatgacagg atagaattaa aataaatttg 45660 caatgatgta ctaatataaa taaatgaagt atcagtaatg aatgtacgaa ttaagtcaga 45720 gcatgtagcc ttgaacaagc tggggaacag aatataaggt cttacataat catactaatg 45780 gctaatattt accaagtgtt tattctgtcc aattaatttt ggtaatattg tgagccccat 45840 tttttgtgag tcccaatatt gtgagatgac agccaaaaag acgtggagac tggattcata 45900 atcaagggct tgatctcaga gtgggttctt ttagaatata ctggaaattt attaagacaa 45960 atttgtctct gaacttcctt gaaaatagaa cttttgttat cagtgctaat agttctttcc 46020 tttttccttt ttatattgag atatattacc aggagaaaaa taaattatct gttaagacat 46080 cctgcaaaag tatactccaa aaagtttccc ccaatttatc ctgccagtaa ggggacataa 46140 gtgtgcacat tttaatccac cttggattaa gatttattta aattaaaatg tattttaaaa 46200 taggctattg tcacttttta tgtttaattt cagtcaggag agtctgtgga catccacagt 46260 atcaagcagc ctcagaactt tattgactta aaacaactta gatgtatatt ttgctcaaac 46320 tacataattt tttacaggct aggtgggtgc tctgtcctct atcctttctc tagaatccca 46380 cgcagaagag ctgtataggg ttttgcatgt gctattcaat gttcttttcc agaagtaaaa 46440 aatatcactt agttcacaat ccattagtca taacaagtca tctggcttca cccacttaca 46500 agttgcctag aagtgcaaat ctaccatgta ccaaaaagga agaaagctag acaacacttt 46560 gtgatcagca ctaggattgc tacatgtttt tacaagtttt atagctgaaa aatggcaact 46620 agccttcttt ggcatttaca ttacaagaga ggttatgcaa ttattttctc ttttgtgaat 46680 tgtttgtgca tgcccttttt ttgtctgaca tattaaaatg ggtatgttgg cagagtcccg 46740 tagaaaagtt ggtggaggaa tttaagttgt tctcaagtaa tcaacaaaga ttatccattt 46800 ctactccctg ccccttaccc gctgctgtct cccttatccc ttggaactaa gaagttgtat 46860 ataggaaaat attctggagg gtggtggtta cctcatcgta acacactata agcaacatgt 46920 cttagaatgg tttccatggg ggcattgatc atttagtgtt tcctaacctg tgattgattc 46980 ataagtacat caatatcaca tgtcaggcta cttcaggtac tctgtaaaag atacctattt 47040 ttccaaggtg tatttcttag gcctctctca atttgaagtg aaataattcc aatctgaacc 47100 agttaaaaaa aacaaaacag tgtgtcctca agtaaaagtt ataggggttt cctaggttta 47160 ggcatggctg gatatgtgaa gtcaaataat aacatcagaa cttactcatt taccactaag 47220 accaaactgg gaagttaaat ttgagtcttc acttcctcat ctatgtatcg gggataatta 47280 ttatttttct cctgtgcttg ttgtgaggat tctttcatta attcatgcaa aactttattt 47340 ttgaggcgga gtttcactct tgttgcccag gctggagtgc aatggtgcaa tctcggctca 47400 ctgcaacctc tgcctcccgg gttcaagtga ttctcctgct tcatgctccc aagtagctgg 47460 gattgcaggc gtatgccacc atgcccggct aatgttttgt atttagtaga gatggggttt 47520 caccatgttg gttaggatag tcggaactcc tgacctcagg tgatccacct gcctcagcct 47580 cccaaaatgc aggattacag gtgtgagcta ctgcacccag cacatgcaaa acttttaata 47640 caatgcctta catagtaata gaaatagaag ataactgcct actattgttc ttactacatc 47700 tactattact gtttattctt atgtatagat tgttcaatac actgaaatga cctaattgca 47760 tctgtcattc tgagatttga atttagctta actattatct ttagacttta ttattgacaa 47820 aaagatgaag gtgacaggta tgaaagattt gaaatatgtt tttcaaatat atcctaaacc 47880 agatttcagg aagagactag aaactggact tgccagattc cacatatctc aatgctgtgt 47940 ggaatttttt ttaaattttt ttttacaatt tgagatggag tctagctctg tcatcaggct 48000 ggagtgcaat ggtgtgatct tggctcactg caacctccgc ctccccggtt caagcaattc 48060 tcctgcctca gcctcctgag tagctgggac tacaggtgca tgccaccaca cctggctaat 48120 ttttgtattt ttagtagaga tgggtttcac catgttggcc aggatagtct aaatctcctg 48180 acttcgtgat ccgcgtgcct ctgcctccca aagtgctggg attacaggcg tgagccaccg 48240 ctcctggtct gagtgtgtgg aatttgacgc acctatgtgg taacaaaatg gatatatcca 48300 gtttatagct ggaactctga ttctgtacag aggtcaggat aataaacaaa agaagagtca 48360 tttgtttatg tcagagattt gttatgtggt attaaatata tccataatgt taggcaaaaa 48420 tggattgtgt atttttttcc tcctaaatag atcttaataa atgggctact ttaaatatta 48480 catacaaaga aatttagttt taaagaataa atttgcttga catgacaaat atcaaaggga 48540 actgaggagc agctacttct ttggccatga ttccaattct tcattcagta tgtatgcaca 48600 cctattcctc atttgtttgg gtcacttgct tcccctctgg aggaatttga gcactgagtc 48660 tgatcaaggg taatagagtc cttgacaaag ttcatggcta aggccagaga cctaagtgag 48720 gttgccattt ggaaacagaa gaaaaggggg ccaattatgg aagtggggag aatagccatc 48780 caaagaaact gagaagaatc agtaagaaca gcaggagaga gcagtttcac ccaagtcaaa 48840 gtaggagata gtgctatctt tttatttaca ttattattat tttttaattt tagagatgaa 48900 attttgtcct gttgaccagc tggagtgcag tggtgggatc atagctcact gcagctgcaa 48960 tctcctgggc tcaagcaata ctcctgctcc agtcttgcta gcagctggga atataggccc 49020 tcaccacggt gcctggttag ttttttaagt ctctttatag agaagaatga tcagcgccat 49080 gttcccagat aaatctaata gacttagtga aaataatcta tgaatttcat caattagaag 49140 ataatgacat acaatgaaag cagtttcact cttgtgatag ggcagaaatg tacaatactt 49200 tctgtctcta tgattttgcc tattctaagt agctcatgta agtggaatca tatggtatat 49260 gtattattgt gactggttta cttcatttag cataacacct tcaaggttca tccatgttgt 49320 agcatatatc aatatttctt ttttaatttt tttaaatgtt tttagagatg aggtctcact 49380 atgttgccta gggtgacctt gaatttctgg gctcaagcag tcttcccacc tcagcctccc 49440 taggagttgg gactacaggc atgtaccaca ttttgctttt ccattcatcc cactggtgaa 49500 cacttgagtt acttctatgt tttagctatt gtgaataatg ctgttgtaac atgggtatat 49560 aaatatctct tcaagattct gttttcaatt ctttggggtg tataccaaga attggaactt 49620 ctggatcata tgataattgt atttttaatt tttgaggact tgccatactg ttttccacag 49680 tggctataac attttgcatt ccagcaacag tgcagaagag tttctatgtc tccacattct 49740 tgtcaacata ttattttcta tgtttttaaa aaagttttcc tgtaatccca gcactttgag 49800 aggccgagat gggtggatca cgaggtcagg cattcaagac cagcctggcc aacatagtga 49860 aaccccgtct ctactaaaaa taaaataaaa aaaaaagctg ggcatggtgg tggggcctgt 49920 aatcctagct acttgggagt cttgggcagg agaatcactt gaacctggga ggcggaagtt 49980 gcagtgagcc cagatcatgc cactgcactg cagcccaggt aacagtgcga gactccgtct 50040 caaaaaaaaa aaaaaaaaaa aatttatagt atccttaaca ggtgtggggt gttatctcat 50100 tgtaagtttt ggcttgcatt tccctaatga ttagtgatgc tgagcacctt tcatgtgctt 50160 attggccatt tatatatctt ctttagagaa gtgtctactc atgtcttttg cccactttta 50220 aatcaaattg ttcctttttc attgttgagt tttaggagct ctctttatat tagtatctta 50280 tcagatatgt gatttgcaaa tattttattc tgtaggttgc ctttttactc tgttgatatt 50340 gtctttaaaa atgtatatta aaaattctaa ccagcttaat atattattga caaataaaag 50400 ttatatatat ttgtggtatg caacatgata ttttgatgta tgcatacagt atgaaatgat 50460 taaatcatgt taattgacat atccattgcc tcacataatt attcacaaat ttttttcctt 50520 tccataaagt ttaatttgtc tgtttttttt cttttgtagc ctgtgccctt agaatcatat 50580 ccaagaaata attgccaaat ccaatgtcat aaagcttttg ctgtatgttt tttcttaaga 50640 gttttatagc ttcttaaggt tttaaatgta gttctttgat ccatttaaat aaatttttgt 50700 atatggtgtt aggcaagggt ccaacttcat tattttgcat gtggatatcc agttttccca 50760 gcacctgttg ttgcaaagac tcttttccat attgaatggt cttagctctc ttgtgaaaat 50820 catttaccgt atatatgagg gtttatttct gaattatcta ttctattcca ttggtctatg 50880 tcttccattg gtctatatct atgtttgtga ctgtactaca ctgttttgat tactgtagct 50940 ttgtggtaag ttttaaactc aggaactgtg actcttccag atttgttcct ttttcaagat 51000 tgttctggct attcagggaa ctttgatatt ccatatgaat tttaggatga atttttctat 51060 aaagagtatc attaggattt tgataggatt gtattgaatc tgtagatcac tttgggtagt 51120 attgctatcc taaaaatgtt gtcttctact ccataaacat aggatgagtt tctatttttt 51180 tatgccttta atttcttcca gcaatatttt gtagtttttc ttgtacatgt ctttcatctc 51240 cttggttaat tcctatgtat tttattttta tttggaaata tttattaggt gcccactttg 51300 ttccccatat tatcccaggg agttattaca aaatgatgag caagacagac atgggctcat 51360 ggggcttcct catgcatgtc ttttggtatc accaatttat ctcctgtggc ctgtggcaaa 51420 tgtatggtgt aattctagtc catgagctta gtatacttat tttcaggtac tcactcagct 51480 gtacttgttt aaaaaaatgc ctgaaacttg atttgcttgt gtggatatta agagtaaatc 51540 aactattcca tacatgtaaa gtacgtttta ttctccctgt aaaactctca atgtttttct 51600 tcaaaatata ctttatgata tatatattaa ctattatttt aagatagttg ggaaaatgaa 51660 gggaccataa tttaaaagaa atggaatatt tgatacatga tgtggctgcc tgtttttatt 51720 cttgtcacct agtctcagtt tttcaggttt ttaaaaatat tataaatgca cacatgtaca 51780 cacacttaat ttcttcttaa tctgtgatct ttcaggtttc tattacatag attaattcat 51840 gtaaattttc ctagtctttt gaaattaaag aaagtcaatg acaaaaggac catcacgtgg 51900 acaaccagtg ggaatgtttc attcactctt gtaagttact tgttcccagt gcaaaagttt 51960 aaaagaaagt ctttttattt attcaaaagt tgaaggtttt tttttttttt ctcttcagca 52020 ccggaaactg tcaggaaaag cagtatatac ccctaatgac tagttcagaa ataaatgtat 52080 cattgttttt aataatttga tacagtatat aaatgttgtt ttgtaaagtt taaattctac 52140 tattaactga acaaaatata aaccaggaaa ttaacatcaa agaaataacc acattcacct 52200 gttcctctcg tctctaacat tctgcttttc ctttgctccg cagggtaacc atggtgagaa 52260 agatgttgat ggcttggatg gagaacaggt actaaaattt ctcattctat gttccgcctc 52320 tactagtttg gcatttacac atgtcatgat taatctagaa atgtaaacat gcatatttaa 52380 tgtttaaagt ttatctatgt ttgttcttat cccaaatata caagaaccct agaagtctaa 52440 ctcgaatcaa cctctcccat attacatttc tttccatctt atttttgtta aatctatcac 52500 ttagacattg ttattgtttt atatagtcaa tgcttattta gccctaccat catatgtctc 52560 caattttctg gaagagttag agaaggatta gtattcattc tttaaatgtt tggtagaatt 52620 cactgaggaa gccatcaggt ccatggtttt cttcaagaga ttttttgatt attgattcaa 52680 tcttcttacc attgattcaa tcttcttacc agttgtaagt ctattcatat tttctatttc 52740 ttcaggattt agttttgcag gttttgtgtt tctggaaatt tttccatttt ataaagacta 52800 cctagttgtt ggcatacact tgttcttagt actatcttag aatgtttttt tatttttttg 52860 agacggagtc ttgctctgtt gcccaggctg gagtgcagtg gtgtgatctt ggctcactgc 52920 aatttctgcc tcctgggttc aagcgattat tctgtctcag cctcctgaat agctgggatt 52980 gcaggcgtag gctaccatgc ccacccaatt tttgtatttt tagtagagac atggttttac 53040 catttttgcc aggttggtct caaactcttg acctcaagtg acctgcctgc cttggcctcc 53100 caaagtgcta gaattacagg catgagccac ctcacccagc ctattataat tctttttatt 53160 tatgtggact cattatttcc actttcattt ttgattttat taatttaaat ttttctcttt 53220 tttttttagt tcatctggct aaaatttcat cacttttgct aatcttgagg aatcaatttt 53280 tggttttatt gattttctct attatttctc tgttctctat tttatctttg ctctaatctt 53340 tatttccttc tttctccaag ttttgagttt agttcttctt tttctagttt cttaaggtat 53400 aaagcgaagt tgttgatttg agaccttttt tgttttttaa cgataagtgt ttacagctat 53460 agttttttcc tttagcacca cttttgctgt gtaccataag ttttcgtgtg atgtagtttc 53520 atttttcatt tgtctctaat tatattctaa tttcttttgt gatttctttg atccattggt 53580 tgttgaagac tgtgctgtat gatccttttg tagttcacaa gcctgatgat tgggttttca 53640 ttcacgtgga tgagatgcac ctccctcaaa cctggttgtt acagcatagg cacattactt 53700 gtctaacacg aaaaaaagga aaaaggagtg tgctgtgcaa tttccacaaa tttgtgaagt 53760 ttctaatttt acttgtgtta ctgagttcta atttcatcct gttgtgatca gagaagacaa 53820 tttgcataat atttatcttt tataatccat cgagaattgg tgacttaata tattgtgtct 53880 ggagttggtt cctcctggtg ggtttgtggt ctccctgact tcaagaatgg agctgcggac 53940 cttagcagtg agtgatacag ctcttaaaga tggcacggac ccaaagagtg agcagcagta 54000 atatttattg tgaagagcaa aataacaaac attccccagc acggaagggg acctgagcgg 54060 gttgccgctg ctggctgggg tgcccagctt ttattccctt atttgtcccc acccatatcc 54120 tgctgattgg tccattttac agagtgctga ttggttcact ttacagagca ctgattggtc 54180 cattttacag tgtgctgatt ggttttacaa aactctagct acagagcgct gattggtgtg 54240 tttttacaga gcattgatag gtgcatttta caaacctcta gctagctaca gagtgctgat 54300 tggtacattt ttacagagca ctgattggtg cattttacaa accccttgta agacagaaaa 54360 gtcctccaag tccccattcg acccaggaag tccagctggc ttcacctctc aatatgatat 54420 atcttgataa atattccatg tgtacttgag aagaatgtgt atgctgttga tgttgagtaa 54480 tgctctgtat gtgtctgcta gatctagttg gtttgtgttg tgttctattt cctttcttat 54540 catctgtctg attggtgtct tcattattga gaggggagta ctgaaatctt taactattat 54600 tgtagaacta tatttctccc ttcatttctg tcagcttttg cctcatatat tttgatggtc 54660 agttattaga tgcatgaatg tttatagttt ttatatcttc tttctgtatt gaacatttta 54720 atttataatg tccttcttta tgtctttttc actttttgga tttaaagtgt attttccctg 54780 atattggtat agccactgct gctctctttt ggttactatt tgcatggaat agcttatttc 54840 tttttttctt tctttttttt tttttaaata aacacatttt tttttttttt ttttgagaga 54900 cagtctccct cttgtccagt ctggaatgct gtggtgcaat ctcagctcac cgcaacctct 54960 gcctcctggg ttcaagcaat tcttatgcct cagtctccag agaagctggg actacaagtg 55020 cacaccacca cccccggcta atgttttgta ttttagtaga gacagggttt tatcatgttg 55080 cccaggctga tcttgaactc ctgacctcag gcaatctgcc caccttggcc tcccaaagtg 55140 ctgggattat aggtgtgagc cactgcaccc agccagaata gctttttcta tcattccatc 55200 tttttttttt ttttttgaga tggagttttg ctcttgttgc ccaggctgca gtgcaatggc 55260 acaatcttgg ctcactccaa cctccgcctc ccaggttcaa gtgattctcc cacctcagcc 55320 tcccgagtag ctgggattac aggcgtgcgc caccacctca gataattttt tgtattttta 55380 gtagagacag ggtttcacca tattggccag gctggtctca aactcctgaa ctcaggtgat 55440 ccacctgcct cagcctccca aagtgctggg attacaagca taagccacca tgcctggcct 55500 atcattccat cttttcactt tctatctgtt tgtatttcta aatctaaaat gagtctcttg 55560 tagacagcat ttagttggat catgtatttt taaatctatt ctgccagtat gtatctttca 55620 attggagagt ttactccaca tttatttaaa gtaattactg ataaggagga cttacttctg 55680 ccagtttgct atttgttttc tatatgcctt atactttatt atccctcagt tcctgcatta 55740 ctgtcatctt ttgtgtttag ttgatttttt gtagggaagt gtttaaattt atttctcatt 55800 tccttgtata tagtctgtag ttattttctt tatggttgtc atgaggatta catttaacat 55860 cttaaagtaa taacactgta atttaaattt aaaccagctt aactttaata ctatacaaaa 55920 agtttactct gttatagctt catccccact tatttcagtg gctgatgtca taaaattaca 55980 gctttatata ttatgcaccc caaaacataa actaataatt cttttaaata cattagcctt 56040 ttaaattata tagaaaatga aatgtgaagt taccaaccaa agttacaata ttaggttttt 56100 gagtaataat tctttaaatg tatttttctc ttaaatcatg tagaaaataa aaagtggagt 56160 tataaaccat tattacaata atacttgatt ttatgattgc acatgtattt acctttgctg 56220 agatagttat tttttcatat gtctttgaat tactgtccag tgtcttttca tttcatgcta 56280 caggcttccc ttgagcattt ctttcagggc agctctagtg gtaatgaact ccctcagttt 56340 ttttatttgg gaatatctct tttttttttt gacaagatct tggtctgtca ctcaggctgg 56400 agtgcagtgg cacaactgta acttactgca gcctcaaact cctgggctca agtgatcctc 56460 ccacttcagc ctcccaagta gccaggacta caggcatgca ccaccatgcc cagctaatct 56520 tttttaatta ttattttttg taaggatgag gtctcactgt gattcccatg ttggttttga 56580 atgcttggcc taagcaatcc tcctgcttca ggctcccaaa gtgccaggat tacaggtgtg 56640 aatcactatg cccagccatc tgggaatacg tcttaatttc ttattttaga aggacagttt 56700 ggccagagat agaatttttg gttaatagat tttttctttt tttttttttt ttgcacttgg 56760 aatatattga cccaatgcct tttggcctcc aaagtttcaa atgagaaatc tgcttatgat 56820 cttattgaaa atctcttgta tgtagtaagt ctgtctttgt tcaatcaaag gtttgattat 56880 aatgtatctc agtgtgggtc tccttgagtt catcatattt ggattttctt gaatttcttg 56940 gatgtttata ttcatgtctg tcatccagtg tcagaagttt ttcagtcatt atttctccaa 57000 atattcactc tacccctttc tctcttctcc ttctaaaact tctgcaatgt gtatgttggt 57060 ctgcttgatg atgtgctaca ggtcccttag gctctgttca cttttcttca acattttttt 57120 ctttctgttc cttagactca ataatttcca ttgtcttatc ttcaagtgtc actgattctt 57180 ttgcctctta aaacctgcct ttgaatctct ctagggaatt ttttgtttca gttatcatac 57240 ttatcatttc cagaatttat ttttggtttc tttttaggtt ttggtatctt tatatttcta 57300 ttttgttcat ttatcatttt cttgattttt ttaacatctt cctttagttt tgaaaatata 57360 tttaaggcag ttgtttcaaa gactttgtct agtggatctt ccatctgtgt tactcaggga 57420 cagttttggt tgatttattt ttgtttcctt tgagtgagcc atagtttcca tttctctgaa 57480 tgccctgtga tttttttttt tgaaaactgc atatttgaac ctaataaagt ggtaactcta 57540 gaagccagat tctcctccct ttccctgtgt ttgctgtttt ttggttacaa tttattgttt 57600 attgattttt tttttaattt gagtgtttta agctatctct gtgtcaagga tcagaatgag 57660 gtatatactt aaggtcttct caggtatttt ctgagtcagt gctttcccat gggcttgtgt 57720 ggtgataaaa gaaaaacttc agctgaatta aatttgaagg agtttaattg agcaatgagt 57780 attttgtaag ttgggcagcc cccagaagca cagctgattc acagagactc cagcacagct 57840 atgtagtgga agaagattta tagacaaaaa aggggaaatg acctacagaa attggtggtg 57900 aggtacagaa acagctggat tggttacagg ttggtgtttg ccttattgga acacagtttg 57960 aacacttagc agtctatgag tgcttggagt atggccgctg ggattgccca agacagttat 58020 tgttacaggt gcatactgtt aaattaggtt tttaatcttg tgtgactatt aagctaggtt 58080 acagttcatc cacaaggact caaatataga agtatggagt ccttctcacg ccatatttag 58140 ttttctttaa gtggtcactt tctaattttc ctcacatata ctgctgcttt tgaatgtccc 58200 agcctttaat gtctggctcc caaaaaggca aaaagaaaaa aataaagggg agagggagga 58260 ggcagtggcc cttaaaatcc cctggaagtc aattcatttg ggggtaggag ggagtagcag 58320 caatttgaga agatacaaaa caatagctgc ctgcttcttt gcacctccga gatcaaaaac 58380 aacaatcagt aatcaaagct cagatcttga tttgcaggac agagttcttt ttgtcacact 58440 gatttccaca agctgcattc aagctgctcc aggaacatgt gcattgctac ctgacaagga 58500 actgtgtgta gggtatgtgt agctcctcct gtgcaaacta aagttggcaa aagtaatagc 58560 aatacactaa acaagccttc ctttggaagg tgcaagcctt caataggatc cacagttcca 58620 aaatagttac atcagataaa ttctgtcagt acaattgtag tagggagata gattttatgt 58680 aggcagatag attttaggta gggagataga tttctggttc ttcctattct gccatcccat 58740 cttctaaaac tacacctcat gttattatca ttattactat tattattatt tatttttgag 58800 acaaagtctc gctctattgc ccaggctgga gtgcagtgat gcaatcttgg atcattacag 58860 ccttgacctc cacccacctc agcctcccaa gtagcaggga ccacaggcat gcaccactat 58920 gcctggctaa tttttatgtt tttgtagaga cagggtttca ccatgttgcc caggctggtc 58980 tcaaactcct gggctcaaca tatctgcctg acttggcctc ccaaattgct gggattacag 59040 acatgagcca ctgtggccag ccctgaattt attttttaaa tagaagattc ataaaaaaaa 59100 ttgacctcac gattataggt aactagattt tttgcaaatg aaattatctt attagaaagt 59160 atattagata taagcagtta tatttttacc cagaaccaca ggcagttctt tctattcaga 59220 gtaaagagcg atattgggta tatttccaaa ttcaaatgtc attctaaaat atatttgtat 59280 ttttatcagt gccaagtgca atggtagttt gtgcaaatta gtgctcgtag taggagtgtt 59340 ttagtactat tgaataataa cagtgtaatt tgaaaggtaa tttcattatg gcaagcttcc 59400 tgggaaaagc aagtggcctg ccttataaat ttggactcat tgttagaaat tacaagttca 59460 ttgaataatg aatacagtag tcactgggcc tttagaagtg aagttttaag ttggtgataa 59520 aaagaggtag cttcatagaa ttccttttgt acttgttttt tttttttttt ttttgtcaaa 59580 ttatcaaacc ttgctttgga tgtaagaatg agttgcgagg ggagcaaaag ggcaactgtt 59640 cttcatgcca aaagtaatca ctcatttagt tttttctaaa cattttcttt gttccagggt 59700 aaataagatt ttcaagccac tttaattata atgaatgatt gttaaaatca tactgaacaa 59760 aaaatgttat tgttattcag gattattcta ttgagtagga cactcaaaaa cttcagttaa 59820 atattaatac aagataagag cctaataaaa acagtagaac agttttatac atgttaaata 59880 gttaaaaaat acatcaatgg ttataataca tttgacaatt taccttgaaa tagtctacag 59940 tttgcttgtg aaaatgagag ttggaagaat tgcagcttgt gagttactac gtagtagtga 60000 aatgagggtt atcaaaattt gcagtctttt tgcagcctta aaaactggga catgtttgtt 60060 ttccctttga gatgcagctc cttggaagca tatgtttaca atagatacct atgtcataaa 60120 tatttaaaat ttgatccaat gcatagtctt ctccttcaat taacttcagt atccctgctg 60180 gaaatctgtg actttttcat ctacactcat agctttactg ataggaaggc tttacgaatt 60240 gcagtggtgt ttgaaaccac caaaccaccc tctagtagca ctgaaaggag caaattatgc 60300 aggatttggt gataacggtc tttgtataga gatagtgctt tctctttgat tatgttttct 60360 ctttgattgt gagaaaggtt gtttttgatc attgcactat ttggtcttca tatgctgaac 60420 aatatttcaa tttcttgtat ttctttctgc cttgttctta ttgacttcat agcacttgaa 60480 gtgatttaag atacagccat gtatttgtgc agagttgtct ctgatggtcc accatgtgga 60540 ttcctttatg cttgttgctc tggagatatc atattccctc ctttctttca aaacacttta 60600 gttcaagatg atcttcaata tcatcaatac ttaaagattt tcttttacat gcacggcttg 60660 ctggttttga acacagatgc ttggatatgt ttgagagatt aattaaaaga gtgctttttt 60720 tttgtattga aaagttcatg agttcaaaag aatggaaaaa cagaacaatg taggctaaca 60780 catgctgtgg actgaggtaa ctggtagatg gctcaggtct gagcgtgtac gtgttttgtg 60840 tactaattcc cacatggatc catctaacca tgcagttttc tgcctttatc tagtgtttct 60900 taacactagt agagatttag cagagataga aaatttgttt tatgctgaaa acattccctc 60960 gtatgtcaat catgttggaa caaattcatg ttttaaaaca agtgctatag cagaaatgac 61020 tgtgataaaa aagtttaaaa aggaataaaa acttaggtct gtcattatag taagtgttaa 61080 ttgactgaaa tctcacttta caagaccatc agattgaagt aaaaaagcac aactatgtac 61140 tgcctttaca ggaaatgcat aataacaaga gatgagcaga gatatatgcc aaatggaaac 61200 aaaataaagc aagtgtggta ttgtaaatat cagagaggct gaaatttaat gataatagca 61260 ataatcagga taaagaaaga cattatacaa taaaattact attaatgaag gagatacact 61320 gttataaact tttatgcacc aaatatagca actaagcata taaactaaaa tctatgagaa 61380 attaaaatct atttgaattt aatataatga aactttagaa taccacttta aatttcaaat 61440 atgtccagta gaaaaaaatt ttaagagatg cttttaataa aacaatatta gacaaacaca 61500 tatacaacac acatacatac atgaatatga acataaatat aatattttac agcccttaag 61560 agaaaatata gcttagtctt agattttaac atataggtaa aaaataaatt aaatattaga 61620 aaaaatctta gagtttatca aacaattgat atactatgat aaaggtttta ttttagaaat 61680 gaatggtggt tccttatcag gaagtttgtc accagaattt ttttttcatc aacttttaag 61740 ttctggggta catatgcagg atgtacaggt ttgttacata ggtaaatgtt tgccatggtg 61800 gtttgctgca cctattaacc aatcacctag gtattaaccc cagcatccat tagcttccgg 61860 atgctctccc tctccctact ccccccacag gcctcagtgt gtgttgttcc cccaccatgt 61920 gtccatgtgt tctcatcatt cagctcccac tgataagtga gaacatgcaa tgtgatcttc 61980 aacaaatctg acaaaaacaa gcaatgggga acagattcgc tatttaacaa atggtgctgg 62040 gagaactggc tagccatatg caaaaaaatt gaaactagac acctttctta caccttatac 62100 aaaaactaac tcaagatgga atgacgactt aaatgtaaca cccaaaacta taaaaacccc 62160 agaagaaaat ctagtcacca gaatttaata caaaatttaa tggtaaagag aataagcatg 62220 tggtcataat agcagatgat gaaaatgacg ttttaaaaat ttatcaggaa tttctaataa 62280 aacgaattac aaaaaacaaa aagaccattt accaaaagca cagctgaagt tttttttttc 62340 ttttgtaagt gatgaaatac taaaaatact taaaattcat tgagggtata gtttccaaat 62400 gaaaaaatag acaaaggaca tgaatgggca attcacagga cagcaaatcc aaaagggcaa 62460 caaatacata aattgatgtg caaataggcc tgatgcaggg cttatgcctg taattccagc 62520 attttgggag gctgaggtgg gcggatcact tgaggtcaag agtttgagac cagcctggcc 62580 aacatgggaa aaccccatct ctaataaaaa tccaacaatt agctagacat ggtagtgcgt 62640 gcctgtaatc ccagctacat gggaggctga agcaggagaa tcgcttgagc ccaggaggca 62700 gaggtttcag tgagccgaga tcgcaccact gcactccagc ctgggtgaca gagcgagact 62760 ctgcctctaa ataaataaat aaataaataa ataaataaat gtgcaaactc attatttata 62820 aataaataaa tagatgagtc agggaagagt gaacccggga ggcagaagtt gcagtgagct 62880 gagatcacac cactgcatac cagtctgggt gacagaatga aactccttct ctagataaat 62940 aaacaaacga ttaattaaat gatacacaaa ctcactggga gtcagaaatg tgaattaaat 63000 tgaaaatgac atattataca cctaattaga ttggccaaaa taataaaata cccatatctc 63060 cctaatattt gtggtggtgt agagaaaagt atttccaaat attgctagtg gatatgtgag 63120 gtactatatt ttttggacag aacatttagc aataaatatt aaaataaaaa atttttaaaa 63180 ccctcatata ccctttgatc cagaaatccc aaaccaggta tttaggctat agaattaaag 63240 taccagtatg tgagcataag tataaggatg tttaataact taattattgt tcatactagc 63300 aaaaaatgga ggaaaatgaa tatccattgt aatagttaac ttatggtacc tgcatataat 63360 gaattatttt gcagctatta aaacttgtca ctgtttgctg atgatatgat tgtataccta 63420 gaaaaccctg aagactcatc caaaaagctc ctagatctga taaataaatt cagtaatgtt 63480 tcaggataca aaatcaatgt acacaaatca gtagcactgc tatacaccaa caaatgacca 63540 agctgagaat caaatcaaga actcaatccc tttacaacag ctgcaaaaaa aaaaaagaaa 63600 ataaaatatt taggaatata cttaactaag caggtgaaag atctccacaa ggaaaactac 63660 aaaacactgc tgaaaaaaat cacagatgac acaaataaat ggaaacacat cccatgctca 63720 tggatgggta gaatcaatat tgtgaaaatg accatactgc caaaagcaat ctacagattt 63780 aatgtaattc catcaaaata ccatcattct tcacataact agaaaaaaca attctaaaat 63840 tcatatggag ccaaaaaaga gccttcataa ccaaagcaat attaagcaaa aagaacaaat 63900 cgggaggcat catattaccc aacttcaaac tatactacaa ggctacagtt accaaaacag 63960 catggtattg gtataatagg cacatagatc aatggaacag aatagagaac ccagaaataa 64020 agccaaatag tgagaaccaa ctgatcttcg aaaacgcata caaaaaccta aaatgaggaa 64080 aggacaccct attcaataaa tggtgctagg ttaactggca agccacatgt aggagaatga 64140 aactggatcc tcatctctca ccttatacaa aaagtcaact caagatggat caaaggctta 64200 aatctaagac ctgaaaccat aaaaatttta gaagataaca tcagaaaaac tcttctagac 64260 attggcttaa gcaaataatt catgactaaa aacccaaaag caaatgcaac aaaaccaaaa 64320 ataaacagga cttaattaaa gtgaaaagct tctacacggc aaaagaaata atcagcagaa 64380 taaatagaca acccacagag tgggagaaaa tattcacaaa ctatgcatct aacaaaagac 64440 tgataagcaa aaaagtatat ataagatttc atttttatgt tgcaaataat tgtaaaagta 64500 tatatttttg catgtatatg ccgaaaatat ggtggaatag ttactacatt ttaaaatgtt 64560 ggaacatatt aaatatgggg aggaaaaatc gaataaatgt tataaagtgg ggaggggggg 64620 aagtggaatc aagaatagag aaaaacaagc aagtgataat agaccacaaa agaaaaaaca 64680 aaatgtttgg gaggcctagg caggcacatc acttgagcca ggagtttgag accagcctgg 64740 gcaagatggc aaagccccat ctttacaaaa aatacaaaaa ttggcagggc atggtggtat 64800 gaacctgtag aacccagcta cttgggaggc tgaagtagga gtaatgcttc ttgaacccag 64860 gaagtggagg ttgcagtgag ctgagatcat gccaccgcac tccagcctag gcaacagagt 64920 gagacagtgt cttgaaacaa aaaacaaaat gtctaatata tggtggtctc atttatgcat 64980 ttatgtaaat tagtattctg ctagtcttgt gctttttaga agagaaaaat tgatatttaa 65040 caattaatag gcttaattat aaatgcatta aaagccctaa taatgaacaa ccttaatcta 65100 ccagaatgag ttccaaaaat ggacaattat atggaaaatt tgggctttaa aatggtgtat 65160 tttgttgagg ctacacttgt atcctgcaga ccagagaggg cataggcaag atgctgacct 65220 tgccttgtct aggaaatact agggatggct ggagggttgc cgatttcaaa aggaagcagc 65280 aggattatat ttaaatgagg ggtctcaaat gggtactcat gcctgtaatc ccagcacttt 65340 gggaggctga cacaggcgga tcacctgagg tcaggagttc tagactagtc aggccaacac 65400 ggtgaaactc tactaaaaat agaaaaatta gccaggcatg gtggtatgca cctgtaatcc 65460 cagcaactca ggaggctgag gcaggagaat ggcttgaacc tgggaggcgg aggttgcagt 65520 gagcttagat tgtgccactg caatccagcc tgggcgacag agtaagactc tgtttcaaaa 65580 aaaaaaaaaa aattaaatgg tggggggtct tattactctg ctttgccttc tccattgacc 65640 actggaacaa attgctttga aggttatggc aggtagccat ctctgtatag gaatatgaac 65700 aattcctacc taactgaagg tatcaatttc taaatttacc aaaaaattct gatgcccagg 65760 ttttcattcc agagattctg attgaattgg tataagaggt gtgtggctgg ttttctgaag 65820 cccagagaga gagagagaga gagagagaga gagagaaatt taccctctca ggtttgttca 65880 gctagaatta caattcattt caaatctatc taaaatgatt gtcattacaa atgattccac 65940 attgtgctta gtaaccagat gaaacaagag ccaacaaggg ctgcattatt taattctcat 66000 ctattagtaa actaggacaa aatagagtaa ttaagtaatt atgatatcta aggcactgaa 66060 agtagggata aaagggaatg tcatcaagtg aatatacatg aggtgagaca cacagactag 66120 tatagaataa aggaaccgcc cttgacagtg cattggaatc acctggggaa ctttaaaaaa 66180 tactgatccc cacccccacc caccactcaa attctgatgc aagttgtcct gggcatagtg 66240 attttaaaag ttacccatga gattctgtta ggtagtcaga gttgaaaacc aataacctaa 66300 aaggaaatag gatgaaaaaa agtgattcgt gtagaggttc aaagaccctt taagatgggt 66360 atcattcatt catttattta ttcagttcag gtattcagtt tagtcattct tttcattgca 66420 ttcaattaat tcaatattta tgaagtaccc actttgtatt tgtccctgaa ttagagtccc 66480 caacatcacc acttgatgga taaaatgcaa atttgttttg actaatttct ttgtgcctgg 66540 aaggcatctc ttattctgag tctggctcta ttagaaagag aggcaaattt tctcctcttt 66600 tctcttctct cttttctttt tctttctttc tttccttttc ttgtttggtt ttagtaaagt 66660 gggaagatta ggggattgag aaagaaagag cctaggaaac tttcatttgg tttctactgt 66720 gttagctacg gattcacatt tcacaggcag aatctcacaa atctgtgaca gaggcattat 66780 tcactccagt ttacaaatga ggattctgag actaaaaatg attaaggaac ttgtaataag 66840 taaagccact tattacaaaa ctaggatgta aactgcaaag ttacttcccc caacattttt 66900 tcttccagtt tctctaaagt caaaaagagt atagccacgt ccccttgcaa atcatatgtg 66960 tatgcacgta tttcaggaag ttgttctggc aatgttgttt ctttgaaatt tcttcttgta 67020 tctttaaaac tcacttgaat ttttatttca cccccatatg atgattaaaa tgcaaaaatt 67080 gggcttaatt tgccattagg aaaaaataat ctgtttctgc cttaagggat gcaactgcat 67140 tgagtttatc aatttcagaa aatcgtgttg actaaagaga actgactcaa catataaggc 67200 tcagcatcta ggaaattgct ctgctctgga ttgcaatcac tgaatttcat agatctgggg 67260 atacaaatgg taacagatct ttttctccgt gcttcttttt tttttttttt ttttaatcct 67320 tgagacggag tcttgctctg tcgcccaggc tggagtgcag tggcacgatc tcggctcact 67380 gcaagctccg cctcccggat tcactccatt ctcctgcctc agcctcctga gtagctggga 67440 ctacaggcgc ccgccagcac acctggctaa ttttttgtat ttttagtaca gacggggttt 67500 caccatgtta gccaggatgg tctcaatctc ctgacctcgt gatctgcccg cctcggcctc 67560 ccaaagttct ccatgcttct taaaccctca aatgctgcct gaattaaaaa ggcctctgca 67620 ttcactgacc agtctcactt aactcactga tgctgatctt ccccccaccc ccatatggta 67680 taatgcttat gtcatgaatc aagaatctcg aggacaaggc aggtggatca cttgaagaca 67740 ggagttcaag accagtctgg ccaacatggt gaaaccccat ctctactaaa aatacaaaaa 67800 ttagcagagc gtgatggcgc aggccgtaat cccagctact ggggaggctg aggcaggaga 67860 atcacttgaa tacaggaggc agagattgca gtgagctgag atcgcaccac tgcactccgg 67920 ctgaggaaat agagtgagac tctatctcaa aataataata ataataataa taataataat 67980 aataataaca atagtaatct caagtgactc atagtcccta ttagtaactc tcttcatcca 68040 gtgaaatttt atttttttgg tagtgattct gtgtctattt caaacactca tttggcagca 68100 ctttttattt ttggcaatta tttattcaac tcttgtaagt atctgtttac tttgcatatt 68160 ttctgctggt ataagctcta ggaaggtaga aacttagtct gtgtttctaa ctaatatatc 68220 ctccacacct agcattttgc ctggtagtat atatattggg catttagtat ttgttgaatg 68280 atcgcagcat aggactttca cagataattt actcctaaaa tatgcttttg acatgtcaag 68340 cttcactgac cttgaagaaa gcctgaagta atttttagtt taattgattt tgccttttta 68400 ttgtattgtt ctattcatga tttcatttca gttgcaaaac attctgaaaa cgttttgaga 68460 gatttgtttg aaatatagct ataagaatgg ttgtccaggg attttttttt tctttccttt 68520 tttttttttt ttttttttga tatagagtct cactctgttg cgcaggctgg agtgcagtgg 68580 tgcaatctcg gctcactgca acctccacct cctgggttca aacaattctc ctgcctaagc 68640 ctcccgagta gctgggacta ccagcatgcg ccactacgcc catctaattt ttgtgttttt 68700 tagtagagat atgaggtttc accatattga ccaggctggt ttcgaactcc tgacctcgtg 68760 atccacaggc cttagcctcc caaagtgctg ggattacagg tgtgagccac cgcgctaggc 68820 ctagggattt ttaaaaaaca aaatctcact caatattcag gattatttat atttttacaa 68880 taataaaatt taaaatacaa ataagcatca aaactcacca acatgtttag tatcgatagt 68940 ttctgtgtta ccaccaattc acaagattag gttaagaaaa tatcctttgg ttgtttcttc 69000 tgtcaagatc attttaggga catctgaagg gtaactgact ccataatatt agatttctat 69060 gcatttccat tgtcttgtat gttgttactg gtttcaagtc tattttcaaa ttactggttt 69120 ttaaatcaca ctcaatattg ccagttgaac atgtaattta aaacttattt cccctcttaa 69180 gttatataaa agataacaaa tttgcttacc tatctactgt tattagaatt ttcagccaag 69240 cgcggtggct cacgcctgta attccagcac tttgggaggc cgaggcaggt ggatcacgag 69300 gtcaggagat caagaccatc ttggctaaca cagtgaaacc ccgtctctac taaaaacaca 69360 aaaaaattag ccgggcgtgg tggcgggcgc ctgtggtccc agctactcgg gactctgagg 69420 caagagaatg gcgtgaactc gggaggcgga gcttgcagtg ggccaagatc gcgccactgc 69480 actccagcct gagggacaaa gtgagactcc gtctcaaaaa aaaaaaaaga aaagaaaaac 69540 tcatgtaatt ggggagctcg tgatattggg aattagatta gtctcaaacc tgccctgtgc 69600 atatcgagta ttgagatata tgcaactact atatttcatt catggtatta ttttacgtat 69660 attccttatc aatcacctgt caaattaggt aattttatta cacacacagg tatttatata 69720 atttttagtg acacaggaca attatatatt atttcatact atcctcacac tgacagagaa 69780 gatatttgtt gttccttaaa aaatcaaaca aacaatagaa agcagctgag aatattgaga 69840 ttcagtcttg cccaaggtca cgtatgctca cacacagcta gaaccagtca cagatctgct 69900 cttcgtctgg tgctgtctac tctgattttc aaaatagtgg ctcctgttca ctctccccta 69960 ttttaatttc agagttctgg cagaatggta agaatgtaaa gaaaatggtt cactgctacc 70020 tctggtatac actttatctt gtaagaattt atggtagatg gtgttgggga acagtgcctg 70080 catggcaatt cttgcagcat ctctgctgct gtatatcatc ccattttctt atttgccaca 70140 ttgtaaatca gctttgcaaa tagccactca tacagggaag taacacttta ggctggatag 70200 tacagtactt tccaattttg tagatgtttt aggaagctat gtctgctgaa tatgccacat 70260 ttcttatcac tgtcatctca aaaccataat taatattaac cgagaaatga tgatcaaggt 70320 aatagtctca aaactctttg gcaaataaac aatgctattg cagcacaact ttgttaggca 70380 ggatgtatat aggtaattaa tacttttagg atatctaaat agctattctg tggggctgag 70440 gaagaaaaac ttcatcagga gagtggcaat aaaaaaaaat gatgcagtac agcaagatgc 70500 cgctgaaaaa taatctttgc agaaagcaga acaggcacaa agtacatatt tggagctcct 70560 tttaagaaaa gttttaagct gatccaactg agtataaagt ggagttgcat gctcagggta 70620 aggctctgca gaaagcattg accaggtgtg tgtttatggt tttcaaagct agaactagct 70680 actgtgccag tggcttttac agcatctggt gggtaggaac cagcatgagt catccgggga 70740 gcactggact agccggggca ccccagtacc cactaaagag ctgacctagc ctcttgcctg 70800 gggctgagaa gctgcatttg gtctagatca aggtcctagg gaggaactaa gcaggtggtt 70860 tgatctgaaa tacttgaact ggcacaacgt caagtaggcc agacaggtag ggcagaggca 70920 ggcatagcaa gagcaccatg aactggtgac ttagtagatg cctggcctca gttctttttg 70980 gctaagggct gctctgttgt tctttgcctt ttctgcttcc ctgtgggata gaatttgcag 71040 atctaagagg ttcaaaaagt tgagaaaagc cctgttacct ggaaaaaata tcatattctt 71100 agttccctag gaaaagtctt ctgattctga attagaactt gttattgacc tttgtcctca 71160 ctggtaaaat cattccctgg tgttagaaaa agtgaaattt gtgctaggaa aagaggagaa 71220 tcttaaaacc acggatgcat ctgtccttaa gcagtaaaat cctaacccga gagaatccat 71280 gaaatctgca gctctcctta ctttgccctt gactctgtca gctcgtttac ttaaaaaggc 71340 aatgtggggc agactgataa gatgggttcc ccagagtata tccactgcct cttcaacctg 71400 gctgcgggtt gacggtttat ataacactaa ctctgaatat gtggaactga cagttgtcaa 71460 attagtattt atacagaatt tgctccatat gtaaaaccag tcaggctcaa gttttaaaca 71520 atggacattg gttttatact ttctgatgct ttaaatgcca tcctagtata actgaacctt 71580 accttggcat agaattatgg taggataagc gccgggctac ttttagtgca cagtcattaa 71640 gtacctctca cgagataact ttatgattat ccctcaaggg aactgtgggt aagactattc 71700 ttccttttct ctcctgtcga gttccagtca caaattctca cagagaagag gcttaactaa 71760 aatttcattt tccccgtaag ttttgtacaa ctctgttaga gcttcagcat ttggaatagg 71820 ccccaaaacc ccctttaata cattcactga ccaaaagttt ctcttctctg catttacaaa 71880 atgaacaata agctaatggt atcatttctg ccagaaactg cacaagctga aaatatacat 71940 gtttaaaaaa acattttaga tacatctgag caatattgtc accatttgta aacatcatgg 72000 aagacaatta ttctcatagc aggtctcaat gacagtgaaa tggtcagagc cagtatacct 72060 gaaagttatg aagatgtttg agaaataagg ctttagtcaa tggcacctac tgaaagattt 72120 ctgagcgtgg aagtatatac aactaagagg aattaagaaa gatcatgtaa taaaatgagg 72180 aagaaaatcc tttatcactt ccccaccaga catttttatc attttatatg tttttccctt 72240 atgtagcact tggtaaattt agaattatat atatgtaagt gagtctttga agaatgcctt 72300 atttccgcaa ataaagtagg agatccacaa gggcaagaac attgcccatt ttcctcatct 72360 tgaatccccc atatactgtg tatgatgcat ggagcctgca caagatgagt gttcaattta 72420 tttttatgaa agaataaatg aattagtgaa agaatgaatg agtctagtag ataattagag 72480 gcttagacag tcaagaaagt aagtgcaagg gtgccacaga gagtcaaaag agttgacagt 72540 gaataatatg actgaagagt ttatgctctg tgccctgatt tatagcctgt tgagtaccaa 72600 tggccctgag tgcccaggta ttgaccatga ccagcaagca ttgtgagacc tgaaggtgac 72660 tcttttctct gattgtgttg gtagcagcaa gctgttatct tactctggat tctgattacg 72720 tactatgtat acagtaattg tgtaataggc caggtgagca ttaaacaaag gctgttttca 72780 tttcttaaac ttcttgtgca attctttagc ataagagatg acaaacaatt tggcagaaag 72840 tcaaatgctt taaaaatatt ttcgggatag tcattaagat atcattgttg taattcctta 72900 aagtttatgg taacttttaa ttgtatgttc aataggaaca aatccaagct ggcctatcga 72960 actggttggt tgtgtaatta atatacataa taaagacatt aaaggaccat cttagctaat 73020 aatagcaagc ttatcttcct taagtgggct atttttttcc aaaacaattt gcaacataat 73080 ttatttaggc tagtttatgt tcaccaaatt tctttatgta ctgtctacta gaagcaattt 73140 gtcttttctt cataggctta taaatttgag ttttaaagcc aattaaagaa aaaaatcaaa 73200 tgaactcagc ctaatttatt gaactaagag cttttacaga ataaaaaata tatggaattt 73260 tatgtcttac tttgtcttta atgactttcc ttttagtacc ttagacttca atgccccatt 73320 atataatttt tagaattgag ttaatacttt aactaataca tctatattta tcttctgtat 73380 ataatagatg tgttataagc tataagctcc tctaaacaat atcaaatatg aaatgttcaa 73440 cacaaacctg tattaaagaa tttgttttta cctcttgttt ggtaaagcat taaaaaaaag 73500 tctcaatagt tttagaaaac atttattcaa ataccaggct agatgttgag gatatagtgt 73560 tgaaaatgta atcttaagtt cactgtgtat tgggaataca gataaagaag ccaaggattt 73620 cattacagtg tgataagtaa tataacagag gaattcacac aatatttaaa gatgagagca 73680 gagaatagag gcatattttt taacctaaaa attgactttg ttgtcaaaga agattttcta 73740 taggcaacta aacttaatgc atttcttgaa ggaaaagaag ataccagcca ggaggaaact 73800 cgtgtgtgtg tgtgtgtgtg tgtgtgcatg agagagagag aggtagtact ttgggtattt 73860 cgagtatgtg caaagcatgt gcaaagatat tctggcatca aatagcaatg tctcactttt 73920 aattctgtgt ggtatttagg tttagtaacc attgatgaaa agttggggga gataaacagg 73980 agacagatca tgaagaaacc tttaaaacat gctaaacaaa tggctcttta ttttaagaat 74040 aatgtggatc cactaacaaa tcttacacag aatagtcctt ttttttttag gctacatact 74100 gtccttcaat atatatataa aaataatacg gcctccttta aaaaatgttg aagtgcaaaa 74160 taatcatttt ttctaagcta aagcaattgt aatctctgat aagattttct gaattaatct 74220 atcatatgat ttgtttaatt aaagaagtct cctttctttc acctacccct tccccaaccc 74280 ttagatggga ttattatatt atttccttgc agtcactcag ttgagaataa cagatttagg 74340 atcagtgtgg aatgtggata aagaaatctc agaatgacct ggggagatct gttagcaggc 74400 tcttgggtat tgcaggtaag agtgatgtgt gcctgtgctg acatagcagt gataggaact 74460 gagagaatgg gattggtata agagatacta tggaggttgc atcagtgaga cttggtggta 74520 gattgaatgg gggatggaaa gacagaatgg ttgatgttga ctgcccagtt tcttgctcag 74580 cctattgggt agatggtgac acatatcaca gtattttgaa ggggtatgga aaagaggtag 74640 aaaagatggt gagttcagtt gggtatctat tgacttagag atagtaatgt gtaataggca 74700 tatgaagata tgggttggag ctcagaagag atgtctgcta agcaattatg aatctgaaac 74760 tcattgctga acagatagtt gaagttacag gtttggccat ggtgttccag gacagagagt 74820 tgactggaat cagaagagta taaatcaaga aactttgggg aaaattccca tatttataag 74880 gagaaagagg aagataaaac ctgaaaaaaa ctgagaaaga gcaaccatag acataggatt 74940 caaatcaaga cagcaaaatt ttggaagatg ctgcaagaag taatcacagt gtcaaaagtg 75000 actgagaggt caagtaagat gaggacctac aaatgtccat tcaatttgga gttaaaaagt 75060 ccttggcaga cagattgcct catttgtaaa aattcaggtg acattttaat aattttatta 75120 agcaaaataa tttatcttga agagatgaaa ccaagccaaa ccaaaaaata ctctgatagc 75180 ataaaagcat ttcctttaca tatttttcta aatgttacaa gacactttgg tcttttggtt 75240 gaagagaaag gagagggaga gggaacatta tatttatggc attaacatcc ttattattta 75300 agtcaattat agattttagt aaatccatat attcaacatg acaaaatgtg cccctccaat 75360 ctatttcttt ctttttcatg gcagtacttg tatttctttt tataaattta aataataatt 75420 ctgagtgtca ttttctagaa tagcattagc gattctaggt tcataatata gagattataa 75480 tgtgaaatct aacaccatat taatgctttt ggaagaaggt aagagataat ataacttaaa 75540 aaataaacaa ttatagcatc ccttatgcag agaggctata ggtttcttca aggaaattag 75600 taaatttaaa agcatcaagg aagatttatt cccagagcaa ggtttttctc tctgatgcag 75660 gttttccagt ttgatcctta aacatgggaa gaaacataca tgaagtttga atctggtgac 75720 aagacaggaa acagaaggga aatacagaga cttaccagtg ttatttaaca gtattgtgaa 75780 caacaggcca acttctattt caaagtagag cgatcacaaa agctcaaaat agccttgggc 75840 agtacaggag agcagatgaa gcactgaact ggatgccaag atgaaatcaa tgagagagaa 75900 caggtgaaaa attgtcagca agagttacat tttgggccta ggaaagaatg tgacgattcc 75960 aaagggctac ccactctctg aaacaggatt gtatgaatta tatttcctag atatatagca 76020 cctgcagtgt ggatggttag gaattttgga gaagttaaat tgattgctta tttcattgta 76080 cgtcaatgca aacatttttc aatgaataga acatatctac aattaacaga agaaagttct 76140 agaaaatgta gcactcccta agtcagtgtc ttcttggtga ataagtagat gtgttcttat 76200 atccttgatc agcaacaccc aagggacaga gacaggactg atgaagattt ctattctctc 76260 aataagttta gcagagctga ttggagtcgt ctgccgtaga acatccacag agcaacgatg 76320 tatatatatg tcagtatatc tcagatgtcc tctaattcag attgtgaggg atggaagagc 76380 ttttgtttct ttagagtcag agggcacgct agacagttat gtgcacaaaa acattccaga 76440 aatcccccat ggcgccgtgt ctggaaatag taatttcttt gcttattgat ttaaaaatgt 76500 ctcaatctgg aaaccaatta gaatttttac gtaaatattt cagtaatcta gcattgtgtg 76560 tctgattcaa gacacctttg aaaatcactg caaggctggg tgagatggct tacgcctgga 76620 atcccagcac tttgggaggc tgaggcaggc ggatcacttg agcccaggag ttccagacca 76680 gcctgggcaa catggtgaga cccccatttc tacaaaaaat acaaaaatta gctgggtatg 76740 gtggaagggg cctctggtcc caccttctcg ggaggctgag acactcaggc atctcccagg 76800 atcacttgaa cctgggatgt tgaggctgca gtgagctgtg attgtgcccc tgcactccag 76860 cctaggtgac agagcgagac actgtgttta aaaaaaaaaa aaaaaaaagc aaatggatgt 76920 ggacacatac aagatttgga aatttgattg cgggcatgac tcagggaaat atgagattaa 76980 actctgctgt ggaaaatgtt caagtcctga tatttatgtc tataccataa tttccatctt 77040 gctaaacgtg agaatttttt aaagaactat ataaaagttg cttggaaaag cagcatactt 77100 ttctagaaag atgattaacc aaatgctaac caaacgttgt caatgaggaa taagtgattg 77160 ttcacatttc tgtgatcctt tgaaacatga taggaatatt taactactcc ataaaatttg 77220 tttcccattt tatatatgtg agagttgctg gaaacaaatg aaacaccatt ataaagtatc 77280 aaattctctc cttggaatga atcgattttc caccagagcc attgaggcaa ttccttagct 77340 cctggttgtc aaaacctggc ttcagagagt gacatctttc agaagtccaa ctcctacccc 77400 tcttgttaaa aaatattcac tgactgcata ttagttagta aataaccctc cctccatctc 77460 tcactgacaa aaaatcggac tcattttcaa attctttcca aaatgtcatc tccttcctga 77520 agtcttttct gaatcttttc aaccaaatat actctgtcct tcctctgacc tcacaaacta 77580 tctcactctt aactttgtga catttatttg tttaatttgt tcatttgcca cactattttg 77640 taacttcctt gaaggcagag tttcttcttc gggtttgtat tatctatctc attagatcag 77700 tattagattg atagattgat tgatagattg atacagagct agagagacag agagataaac 77760 aggtagataa ctcatgttcg aatatcttgt ttttagtgga attaaatttt agagaagaaa 77820 agcaggcaaa cataaaagga ttttgaaaga tagaagatac tttggccaaa aacatattta 77880 tcagcagcat acaaatgtgc ttacacatgg aggcattatg gcaacccaaa tacaaactag 77940 ttcttttttt gtcaacacat ttttcactat tgtcacagta gcttgtttac catatttttc 78000 tcttgactca cttgcctcct attattgggt cctagaatga tcatgttcct gctggataga 78060 gcaagacatg tttagaagtt ttgcttatgg aaatcaaagt tgttacaatt tcaaggtcat 78120 cttatctttg cactttaaat ctactattta gttcgtctta atctttagct tttgtctact 78180 tccaacctct gaaagtaatt ttgcctttca ttttgagctc catccctgtg tagagtttca 78240 gatgtctctt ggctctccca gtcctccctc taaacaactc acaaccctgg catgatcttt 78300 agtaagattc ttcttaggtt tttttttttt tttttttttt tttttttttt attaaagggc 78360 aaggtgggta ggggaatggc atagaagaac acatttggtt gtttttcagg gtacctaagt 78420 ttatgtaatt atcatcaggt agctcttgct ctttacatgg tttgatggtc gtttctctgc 78480 caagtggtct tgaagtcttg tcagggacac ttctgcttca gcaatgattt ctataggaaa 78540 gtgaagccca taacattcaa acttgggttt tttatcttct tgattactaa ttagctctaa 78600 cttccaatat ccacaaataa aacttcagag tcaagttaaa agtctttaat tgattacttt 78660 aaatttgaag ggtatgcata cttatttcca tggaattgca agatcaaagg ggatgaaatt 78720 cctgaaagca gtactgtgtc cctcaaatcc tctgatatta actgctctta aggatatggg 78780 gaaatgggct agtttgggat ggtctgtatc atagctctta ggaaataaaa aataagaatg 78840 gaggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg 78900 gatcatgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc cacctctact 78960 aaaaaataca aaaaattagc tgggcgtggt ggcgggcgcc tgtagtccca gctactgggg 79020 aggctgaggc aggagaatgg cgtgaatccg ggaggcggag cttgcagtga gcccagatcg 79080 cgccactgca ctccagcctg ggtgacagcg agactccgtc tcaaaaaaaa aaaaaaaaaa 79140 aaaaaagaat ggaatagatg cttcaaaata cattaggacg aaggtaaatt acacatttaa 79200 aaacttagat gtgtgtgaga atgatgtttt taacaaattt taaaaggtga ataagtaaaa 79260 taaatttaat tttgaaatag ttctacattt ttttgtaaat tatttcttcc atgatgattt 79320 agagggacta tcaacaaacc agtacaaata tttcataaat aatatctgcc tgttttctaa 79380 ccaattgagt aatttgttgc acaataagcc acttcacatc tttctgcaag taaaacatta 79440 gctgtgaata gtaaagacat tacacaatga attagggcac aattaaaatt tgatttaaat 79500 atttctttag gggagggaac accacacttc cacttaatga aaagaaacat ttttagagtc 79560 cagaggtctt ttgcttcttt tacacctatt atgccctgac tgcatagggg acaggttcca 79620 gcagctcagg ctttggttct cacaaagtat gtttccctgg gtggagcagg ctggtgcttc 79680 agttgaaccc aggaaccttt ctctttggct tctttctctg accattttcc tttatgtgtt 79740 ttaggaagcc gtctcggcac ttagagtgct taatatgctc aatatgcaca tgaattccct 79800 tggcaagaat cttgtcctta acttgtttac aacactgcca acagcatgct gggtaacact 79860 gtagattctt ccaattttgc catggtaata cttgtgaggc attccttttt gaacaggact 79920 cattcccttg atgtctacag tatcaccttt cttctaagtt tgcatgtaca tggccaaatg 79980 aacaactccc tgttttccaa atagactgga gaacatgtat cagtgcctat cctctttccc 80040 tgtgtgttca tcattttggt gaattactga aagatggtgg ttctggctga aaggctaatt 80100 ttttaattta aaaatttcta atgattctac ttttaataat ttctaattaa tttctaaaaa 80160 tcaattgtat agtattaagt aaatttcact tttcagaaat gatctaaatt tgtttttgtc 80220 taaacatacc aatatcataa tttcagattc agattgattc tgtttagcaa gccatttaaa 80280 atttgcttgt agttcccggt aatagtatga gaaggcaact tcttcttatt tatttatcca 80340 aatttgcagt actattcaat tcatacagta tttactcata tcccatttta gttttggtta 80400 atttctcttt ggagaaatat gggagacaat gaaatctcac tttggaaaag aaaaagagaa 80460 actaattctt attcagtacc tattacatac caaccactgt gtcagatact ttaatctcac 80520 aactattctt tgaggttgca aaagttttgt gcatttttat acggtttaag aaataaagta 80580 tcaagaagtt aagtaactaa gttgcaaata acctaaatga ctcaaagcta atggattgag 80640 taaacttttg tacattcatg tgttacaatg caaaaaagca atgaaagatt agtaagtatg 80700 ttattatttg atatcataaa atgcctacta gatattgcca aatttaaaaa atagtacaca 80760 caaccattta tatgtatgta tatgggtgtg tatacacaca catctgtttt ttaaaaaata 80820 aagacctaca tacaacacaa gactcacaga atcacataaa ataaaaaaac cacattaaaa 80880 cagagaaaac tggtaaaagt tgctttagca cttatatcag ggtagtgagt tacagatgat 80940 tttcattctt ttgtttattc actctaaatt tctgacgatg agtatatctc agctttatat 81000 tttaaaaaag caacgtatca tttaaaaaat acgtattcca atgttacaca gttgtaaaca 81060 ttagagctca gctttgaaat ataaggttat attctttcct ctatgatcaa agatagacta 81120 ctcaggccta aagaaaaaca ctcagatact cccgtgtggg ggctggggga cagggagaga 81180 aagagagaga gggaagaaag agtcaaagac acacactcac acacacacac acgcacacac 81240 acacgggggg gcggggtgga catagagaaa agagctttca tttggctgtt cttgacgtta 81300 gaccaccttc actctaatta ctgactgtac agttgtaaaa gcccttccca attacatata 81360 aggatatttt tgagtcctac tggttgctgt tgcaaagcta taaagatctt cataattacc 81420 ttcaggcagt taaaaattta gagatccaga gaggtctagg tatagattct tttggaatag 81480 cgggccagct gaaattgtta ggtggttatt attcagtaca agggaatttg gctcttcctg 81540 tttaaatggc aaatttaacc aatgcacaga ttagaagact ccaaaccaaa tcaattgtat 81600 atagagaaga acctagaaaa aagaaaggaa tccatttaaa cagcagagga ggtatagtaa 81660 ttgggcctat agatcacagg cccaactagt aagattgtat tactaagcca aaatcatcaa 81720 taaaagaaaa taaagccagg tgactaagtt aaggtctagt atgacaatgg tcatgaatca 81780 acacaaataa tcttggcaca aaagtttcag gacaggctgt ccaaaagcag ctgagtagaa 81840 gattcaagta aggttttatg tatggtatgt tacgctgatc ttcctccctc gcttacttcc 81900 ttgctttctc tttccctcct tcttcctatt cctccctccc tcccttcctt cccttcctta 81960 acttccttct ctcattttcc ttcttttaca aaaataatct ctactgcata cattgtttga 82020 agcacttata atgatgaata agatgtgtct ctcacctaaa aagagtttac agaatatgtg 82080 tgttgaggtc ataggttaat atttgtgttt acttattata tcttgagtac tcatttgcag 82140 tgttttagtt gttcacaatc taacatatgg atttaatgct gaacatgtgg ctcctgctgt 82200 agaaagttat gggcctttgg gcagaaaccc tactcctgac cttcaaactg aaatggatgt 82260 cctaaatgat gtaatgtgta tagctaatga tgttatacag tagaactcat ttgtaatagt 82320 ggtattgaga aactgggcta atggccacat gtagacttag taatataatg agagaaattc 82380 atgatgaaac tttaagtaag aggacatgat ttttcttcca gtataactga atctttgcta 82440 ttatgagaaa tattagggtg aaatttaata gaattacaca aaacatattg aactactgtt 82500 ggaatagtat ggaatgtgat atcaaaatca tgcttcaata gaatacaagt ttaggcttga 82560 aatatattat atttcaagtt gaaattcatg acagctgaat aagggatatg gtattgcctt 82620 ttaatgagct aatttcttcc caattttaag agtgaccaaa ggtcagccct tttggattgc 82680 acagcacaca cttgtaagaa acccttataa atcatcctta tgttcaagtg caaggcaact 82740 ataacacaag cccatgtatt aaatcaaaag tgcctttcag aatatgagag agagacgcaa 82800 atgttcacag taacagtatg ctaagggctt tatgaaatag aaaattaacc ttggaagttt 82860 ctcagtggac aaggcttaga taaaataaaa aagttattcc tttggtatgc ttagaggata 82920 ccaaacaatg tagaacaatt tgtattttaa tgtggaagtt gttccgtctt gtttatttct 82980 gagtgtcagt ccttctgcct tatccccatt attttcaaaa ctgtaaacta catacagcat 83040 ggctctaatg aatcaggttg acagggattg ctaatgcatt ggaacatttc tgaatgttca 83100 gagaaatttg aatttagtaa gtgccatatc tgaaaccagt acagaacctg ggggtggata 83160 gttggtattg gtgggtggtc agaatttgac acccatcccc aaacttcaaa agggatttag 83220 agaagtattt ctaataagac tgaagttaaa aggatatgac aatgggaata ccaattggtt 83280 taatcctttt gaatggcaaa ttattattaa gaattagcta gcattaattt agtactttct 83340 atatgccagg aactgtatta atttatttat atataattta ataactgaat tacttactat 83400 gtgtaaggat tcttaaaagt attaatgggg ccaggcacgg cggctcacac ctgtaatccc 83460 agcactttgg gaggctgaga tgggtggatc acaaggtcag gggatcgaga ccatcctggc 83520 taacacagtg aaaccctgtc tctactaaaa atacaaaaaa ttagccaggc gaggtggcag 83580 gtgcctgtag tcccagctac tcgggaggct gaggcaggag aatggcatga acctgggagt 83640 tggagcttgc agtgagctga gatcgtgcca ctgcactcca gcctgggtga cagagtgaga 83700 ttctgtctca aaaaaaaaaa aaaagtatta atggtcttga cctagtattt ctatatccag 83760 gaactcatag taataattaa tgacccatat aaagaattat gcactaaaat gtttgcttca 83820 gcattattta catagcataa agtctgaaac aaatgtccaa cactgaagaa tgcttaggaa 83880 aagttacata aaggatatta tacagtcatt gaaatcatgt ttgcagtgaa tgcttaatgg 83940 gaagatgatc tccatgcaat gttaagagaa aaacaaagta gcacgcaaaa tagtatatat 84000 aaaatacttc aaaatataat aaacaataaa cattggaact tttataaaaa gacttagagg 84060 agatacagca aaatatcaat tgtggttata tctgggtaat gagaattata aataatttta 84120 gtttttaaaa tttatttctg tattttccaa gttttttaca aaaagtttac atcaagtata 84180 taatttgaaa aataagctta aacattttct gggtgaaaag aattcctggc ttctctacag 84240 gcagattccc ttcacacatc ttcctgccca actactgtgt cagtgggacc cctgctcatg 84300 tgaatatttc tttgtgccag tgtttgggtc tccaggctag agcaattttc ttctgggctt 84360 tggagcattt tgtttcctac ctcttagtaa tccaccccca acagttgact cctggttttg 84420 gcatccaccc tttcatgaag ccatcctcag gttgaggtgg ttaaaccatt ccattccacc 84480 attagttgct cactgccaca ctggctggct tcatgcttta gtgaagctag taaaacctca 84540 agggatgtat caagtatccc aaaatctact taaaaaattt tgggatgacc agggggcata 84600 tttagccatc tttagctctc agaatttcgg ctacatctct ctaccaataa tcctgtttat 84660 actgaggact ttactgataa gatgggttac aagaatgttt tcatgcaagt ccctaggact 84720 cctcggtaaa ttaagggtat gggactttgg gattaaaagt cagttgctct cagagacgtc 84780 ggagcattat agatactcaa gaagtatttg atgaaggaaa gaatactagg ggtgataaag 84840 gtagtcttta atatttttac taatcaaaag aataagtatt atttttcaga aaataggagg 84900 tgggaaagac atatggagga agcagggaaa tcattcagag gcagggaaaa ttgatggaat 84960 aagtgccgca ttttgggaca gatattcagg gttaataagg aaaattaaga gaatagtgtg 85020 atatgatatc aatggacatg cagataactg atatcagtcc tttaacaaag gaaattgcaa 85080 attgtttttt caagagtttc aaagaggtac aatttttatg gcctagacct tctgtggctg 85140 actgtcatag gtgaataatg gctgccccaa aatatcaagt ccaaatcgtt ggaatttata 85200 aacgttatct tctttgaaaa aaaggtcttt gcagatatta caaagttaag gattttgaaa 85260 tgaatagatt ctaccttgga tgacccagat gagctttaaa taccatcaaa agtgtcttca 85320 taaaatagag gccgagggag attccacgcc gacacacaga ggagacaaac agaagaggag 85380 ggtgcaatgt gaccatggag acaaaaattg gggtggcatg gccacaaaac aagaaacact 85440 cggagttgcc caaaggtgga agaggcaaga gcagatactt ccctggatcc tttggagaga 85500 ctgtagtcct actgatgcct taatttcaga ctttgggcct tcagagcagt gagggaacac 85560 attcctgttg ttttcggcta gcaaatctgt ggtaatttgt tatggcagcc ctagaaaaca 85620 cacacagtga ataaaataac tcttgtgtgg gaaaacagcc tcattctgat tggttgggga 85680 ggaaagtgat tgccaatagt gtacctgtaa gacggtagaa ggtgaaatca gctgtaaagc 85740 gtaggaaggc agtggtggta ggtgtctagg agtacggtgg ccacaatagc atctgctatt 85800 gtaagagcac tggggagtga aggtgggaga ataagagtgg aagggtcact ttcctgagtg 85860 ccctaatccc tcttttagtt gacacatcag acctagccat ccagatgaga tgacattgtt 85920 ctatttaaaa gactgggtgg gaactggagc caggatactc tgtggggtta tttatccaaa 85980 tccggggtta ttattcaaaa gtgcatggct gggcaaatag gtttatgcca tagtttatca 86040 agacggaaac caaaagaaag aaagttgcca aattaatttt tgggggcttg aagaacagtt 86100 gtttgtaaag aaatggttta aattacagat taaaaaaaaa acacacacaa aaatccgtgc 86160 tgcttcaaaa ctcaaactag actacctcca caagcattcc ttcctcaaag ccaccttgta 86220 gacaccagac ctagtaaatt tacatttgac agacaaatag gaaacttttt catgttacac 86280 aaaggcaaca ttataatcta gctgtcaggc cttagctcca ttgatgcact gagatgtggg 86340 ccagatgaag ataattcagg gaatctagct ccagcgagag tttcagggag ccctccctca 86400 gttagttgat atcccaaacg cttatcacaa aagcaagaga aacttgataa cgacctggca 86460 gtggtgacca gacttattct tcctagaaca agaaagtgat attcagagat tgacataccc 86520 ttaaaacgat caaaagggaa aagcaaggtt ttctttttag aggttcaagt catgctgagt 86580 ttggtcagat agtgtgaggg gcccagtcga gtcacttgtg agggtatata aaataaagtt 86640 gggaaacaaa ggaaacgagt gaaaagaatg aggtatttat tcactaaaag gaccaatgaa 86700 accgatcccc tctaagtgta aaaggaggag tagagattac tgtgcctgtt gtttaaaatg 86760 tgtggacaga agattatttc tagaggacac ttagtatata tttaccatgg tatgcatcaa 86820 aggcaacaga attttgttac gtcgcttacc ataaaatatt agaataaaaa atcaatattg 86880 atgtttctgt tttaaaaagt aatacatgtt cattatttaa aaaaataaac aagtgctgta 86940 ataaaagtat atagtatgga gggcgacatt ctcagagata cccacttctt ggtgtcagcc 87000 acaattaact gtttggtgta caaaatcaca gaaataaggg ctgataaatt tgtagatgct 87060 gtctaatcca attcccttat ttcatagtgg aggaagatga ggcacaaaca gggctacaag 87120 gctactgagt tactgaagat tgtccagtta gttagagaaa gatgctggtt tgctcttata 87180 ttacctacag atacagataa ttttattcac cttttttttt tctgttgagc tatcagggaa 87240 acacatccta gatattcaga accccctact aggttgacta aaacaaagca aggaaggaaa 87300 ttttaaaaat agcagagggt ctctaaagac agctgcttga ggtaagcaaa tgaacaggtg 87360 tttatgattg aattattagc ctcaataaat tgaagaaaac accatttttt tttcaaactt 87420 gaggtaaaaa cacaataaca atagagaatt tatcactctc cagaactttc tgtgttgaat 87480 acaggagtat atttttagct ttttctctag gaaaacggct tccagtttct gaatcatttt 87540 ggctaatttt tatatgcttc cgatctatcc tctgcagcac tcccgcaagc tgcttatttt 87600 gtggcaaata gtagcaaaca actttttatt tttttcagag atatccagaa tttcgccaaa 87660 tggtgatgtt ttttcctcta aaagagtcct tgtgaaaatc ccttacttct gtctaataaa 87720 tgccatattc aatatttact ttctccaggg acgattgttt cagtactatg aaaatctcag 87780 aagagcaact agagtcattt aacctactct taatctgtcc taatgccatt tctctcttaa 87840 acgtgtctcc atttttttca gaattgtatg cctcttagtt tttcaaagca gtgagtaggt 87900 tgagcagaga aagggccaat acagcatttg ttctcctcat actgctgagc atagtcatca 87960 aaatgtccta agatatgtgt atgaataatc atctaagaat atgtgtatat tctgtgttca 88020 tatagaacac atttatatac gtacatgttc tctgatacat atagggttct caatttttga 88080 ataggaaagg gacttggact ttgagatcta tagatttggg atcaaatatc aacttctact 88140 tcatggctat gtgatcttgg aaaagtcatt tagcttctga aatttagttt tctcacttac 88200 aaaatgagga taataatgac tatcttaagg tgatgttaca aggattatat atggtaatga 88260 cataaaaggt ctgtttgata aatgcttgat gtatcagtgt caacaaatgg caattattat 88320 tttctcatat aatcacatat attttcaaaa aactaaacaa tactgcctga aaatattcat 88380 catttgccct ttctgtcatc tagaaaatgc tacttctttt agatcatttg caaattgtag 88440 ctttgttcag tctttcccaa acttacactt tctcccctgc tccatatttg acagctatag 88500 ctgctctgct attatcactt tctggctcct cttgttcatg catcatttca gattggattg 88560 taacgtgctc tggaaccact tcaggtattc tgccctctgt gcaattgcct tagaatcaac 88620 ttctcccaca attagttgtc actggttaca tttttatcgg ttaaccaaaa tgcttagttg 88680 aacatagatt aggttgtcat gcctctggag agcctgcagt tcagaacttt tttactggac 88740 actttctctt gtcacttgat gctaagagga acatgtcaac agtgaaactt atctgaaagc 88800 tgaatatgaa gtaactgata gacttaggtg tcacattata tagtagacag tagtgttgct 88860 tgatagaata ttgtttgact ctatgccaaa aggcacactg ggttcactat agctgtctaa 88920 cttttcccat atcagtatgt catttagaag cttgctaaaa atgtagcaag aggccaggat 88980 tatttttagt tggaaaagct tcatttactt ctcacaaggt aaatagatct ttaataactt 89040 ctttaattta gtcttgtttt taacacatga aatgggaata aatattcagt gatttgaatg 89100 atggattctc tataacaatg aaatatttaa atgctcttac taggagcagt aatcgaccgt 89160 aacgtttctt tttgacactc acaagtattt tctgttaagt gggagtaatg tttttaaaac 89220 taaacataaa atcacaaaca tagagcattt tcaatttgaa cttttaatac ttagaagtga 89280 gcctttattc agaaggctca tagaagtatt ttccttaatt gttgcatgca taaggatctc 89340 ttctaaatta acattaattt tatgattaat tttgaaacag aaatctaatt tttactcact 89400 ggcatgaaat gtttcttgga acaggaaaga gaaatttatt tttgtttctt actaactcag 89460 tcatcattta atgccatctg atattaaata ccatattttc aacaatctaa aatgaataat 89520 ttacaaaata ttttaattat attgttatga tattaaatat ggtaggctat gtatagtaac 89580 acaagctcac caataatgaa tttgctgaga ttaactgtga aatctggttg agagatatgc 89640 ctgtggagga ttatcctccc atggtaagaa ccatgaaggt ggttcattca tttgactaaa 89700 gctttgagct catgcttatg tggtagacca cttttcctcc atttcttatc aaaaaaatgt 89760 gtagccagag gaaaacagta ttttcaaata tttcttatag tagattaaga caatagttgc 89820 tattgtttgg atgtttgttc tctgcaaata tcatgttgaa atttaattcc tagtgtggca 89880 atgctgggag gtgggtccta ggtcatggga cacatcctgc atgaacagat taatgttctc 89940 tcttggtgct gagtgaggtt tcactttatt atttcccata agagctggtt gttaaaaaga 90000 gcttagcacc tcctccttct ttgtcttggt tgctctctgt acatctgatc tctgcacact 90060 ctggctttcc ttcaccttcc agctagtgga agcagcctga ggccctcacc agatgctcaa 90120 tcttgaatgt tccagttcca gtcagcaaaa ctatgggcta cataaatttc ttttctttat 90180 aaattaccca gtctcagcta tttctttaga acaacactaa gcagactaag ccaatagctc 90240 ttctatttcc tgtatgtgta gtgcttgaga atagatcatt atgtagcaaa aattcctgat 90300 ctttgacttc accagaactg acggaggtgt attttgttgt tgctgttatt tttctccctt 90360 taaattgtct aaaggactat ttatcaatca atttctggcc atttcaaact tgtcgtattt 90420 tactgtatgg gtaggtttta gtcaggaaac cagaagccac tctggatatt cagataggaa 90480 gggtttcgat acagtaattg taggtataat cattgttagg gctgcagagt gaagatcagg 90540 aaagtctccc tgttgagtag acctacagag cattctcaaa agttcatctg gaagctgctg 90600 tgaatcttaa gaatcaacat tcctgctgcc tgagatactc aaagtggctg atttgaaagc 90660 tgtcatgcac agaagctcat gcctgcatgt gcatatttcc ttaattgttg atagaaaaga 90720 atgctttttt ctgctttgat acccttacta caagcttgct tgtcatttgc agagtaatct 90780 gtagccatcc agttaaatgg gtactgggaa gggagttttg ggtttctctt tgttgaagta 90840 gacaaaatga taaaacaggc acagtaatga tgtcaagttg aagacaaatc tggcatagcc 90900 atgttttgtc aacctagcat tcgtatatac tcttctaccc acattctaac ttcaaaaaca 90960 accatccaac ttcatgcttc cacatgatat gatctaacta tgtcttatcc agccatatat 91020 acatatacat atatgtatac actctctccc tacaggggta gacacaaagt tctataaatc 91080 actgtatgct attttggggt gatgttcatt ctttttctaa ctcagttcca attctccttt 91140 ggtatctttt aacttataga ctaaattata aggtaaatct ctattaatac acttcgcatt 91200 agataaaaga tgaggatggt ggcaaaaaac tggttaatat atgcaactat gtacatcata 91260 aatcagaaaa ggaaataggc ttagctttca catgcttcgt ttctacaagt gaataagagg 91320 ccataattgg tctttacgat tttgctttct ccctatccat ttgatttgtt ctcagtgggc 91380 gcgttatctg gtcatggttc ttcacttgat gggatgatgc aaaacctcat ttttgaaggg 91440 ctagagccac tagtagcctt gcttttttgg gttgctctac tcctttgcta accttttaca 91500 ctagatatac aagtactgag gggcaatcca gagaatcctt tgaatcctct ttgcctttat 91560 tatgcagcag caactctatt tctccttgac aatcaatatt attcactccg gttagtacag 91620 caagcccttc tttgactgtt gccttagtgg catgaagaat tcaaagtgat agtttaaatt 91680 tcacattcag tagaatcatt gttaggtcca ctagtgtaag cattcatttt ttagaaatta 91740 agtcctctaa acctgcagag ccaaaagtgg ttaagagaag tgatatggtt tggatcttta 91800 tacccaccca aatctcatct ggaattgtaa tccccaggtg ttgagggagg gacctggtgg 91860 gaggtgattg gatcatgggg atggttcccc catgctgttc ttatgaaagt gaatgagttc 91920 ccgcaacagc tgatggttat aaaagtgttt ggcagttccc cccactttct ctgtctcctg 91980 tcgccatgta agaggtgcct tacttcccct ttgccttctg ccataattgt aagtttcctg 92040 aggcctcccc aaccatgcag aactataagt caattaaacc tctctccttt gtaaattaca 92100 ttgtctcaag ttgtatcttt agagcagtgt gaaaatggac taatacaaaa agcaaatctt 92160 ttgtgattgg gtctttaaga ataacagaga gaggaaccac tcccattccc acttcttggc 92220 tcctttatcc atgtcttctg gccatgggaa aagatagtgt catgttgtca tattgtttgc 92280 tagttcagaa catatatgaa atctttcagg acagcacata gccaaacaag gtattattac 92340 ttagccagca cccaaaatga gtttttaata gggcattcca ctgttatgtc aggcaggcca 92400 acttgaggtg atgtggtaca ctgtaagacc aataaattct acagatgtga acatttccct 92460 cattctttgc tggtcaatgt gttctttggc caggagcaaa gttatatggg catcattaaa 92520 gagaatcagg ctttccatta gcctgtggat actggtactt tacaaaggca gagcagacag 92580 ggatggcaca ttcatatcta ctgtgtttat tctggtaaaa catgctgttc tttcttccat 92640 gatggaggta gtcaacatgg ctagcagatc ccctcaagaa tagtgccaca gaaggaaatc 92700 agcatcaaac tcagctgaca acatactatg tttttagcaa ctgtgatagc tagaatagtc 92760 ttattgaaga gaagaccctg cttttgagcc catgcatagt ctctatcact gacactttga 92820 ccattttatt tatgagccca ttggtcaagc tcaaatggct gggaagaggg tggctaatat 92880 tcacagaaag cgttatctcg actttattat tcgaaaaatg ccttgcagtt gaagcctgtt 92940 tgtgagcaat tacttggggc acaaaaaatt tcaaactctt accattccca gaggtttacc 93000 atttcttact cagacctttg tgttatcaat cccttatttt attttcttca aaatccggag 93060 aaatgagaaa accactttcc attgtccagt gtagatatgg catctctttc caaaaaagaa 93120 aaaaaaaatt gaatgcagtt ctgcccacta gaaagatttc ctttttcccc aatccttaac 93180 ggccattaca tagtgggact gaaatgctac atggtacaag actattgtgt ggacatatct 93240 acaaaccagg actgatttgt tttacctcag tcacttgatg atgaactccc cctgaggtcc 93300 caaatgtggt gtgtggtata gttgtcaatg caagcttttg atgccaaaag ttcaaatttt 93360 gccatcagtt caaattctac cccatatctc atgtttctac tctggctggt gtgaagggca 93420 acttatgcca aacttatgtg agcttgctga atttttctct atagcacaac acacctgtgc 93480 tttcaggact aattgagctc agttgcacat acgccacttc agtttgataa tggaatgctg 93540 ctatacactc tttaaaaaat taaatcaatg ttattgagat ttaatttaca taccaaaatg 93600 cattcatttt aagtgcagaa tttgatgagc tttggcaaat gttctccctg tatgaccttc 93660 acgaaaccga atatatagaa tatttccttc attcaaaaat tacccagtgc ctttttgcag 93720 tcagtacctg cacttattcc tgccccaaac aaacactgat ctgattttta tcactataga 93780 ttggttttgc ctattctgga tttttacata agtggaatca tacagtgtat agtcttttat 93840 gcctggtttt atttcactat ataaagattc tgagattcat ccatgctgtt gcgtatatca 93900 gtagttggtt ctgtttcact gctgagtagt atcccattgt ttgaatatat cacaatttgt 93960 ttacccatca ctgtgttgga tatacttgta caagttcttt ttttttaaat cttttttttt 94020 attatttata ctttaagttt tagggtacat gtgcacaatg tgcaggttag ttacatatgt 94080 atacatgtgc catgctggtg cgctacaccg actaactcgt catctagcat ttggtatatc 94140 tcccaacgct atccctcccc tcccccaacc ccacaacagt ccccagagtg tgatgttccc 94200 cttcctgtgt ccatgtgttc tcattgttca attcccacct gtgagtgaga atatgtggtg 94260 tttggttttt tgttcttgcg atagtttact gagaatgatg atttccaatt tcatccatgt 94320 ccctacaaag gacatgaact catcattttt tatggctgca tagtattcca tggtgtatat 94380 gtgccacatt ttcttaatcc ggtctatcat tgttggacat ttgggttggt tccaagtctt 94440 tgctattgtg aatagtaccg caataaacat atgtgtgcat gtgtctttat agcagcatga 94500 tttatagtcc tttgggtata tacccagtaa tgggatgggt gggtcaaatg gtatttctag 94560 ttctagatcc ctcaggaatc gccacactga cttccacaat agttgaacta gtttacagtc 94620 ccaccaacag tgtaaaagtg ttcctatttc tccacatcct ctccagcacc tgttgtttcc 94680 tgacttttta atgattgcca ttctaactgg tgtgagatga tatctcattg tggttttgat 94740 ttgcatttct ctgatggcca gtgatggtga gcattttttt catgtgtttt tggctgcata 94800 aatgtcttct tctttctgta aacaagtatt actaattttc ttgggtaaat aagaattaaa 94860 tgactggttt gaatgttctg ttcatgtttc gctttacaag ggactcacaa aatgttttcc 94920 aaatgatggt tgattattcc caccaacatt atagtagagt tctaattgct ccacattttt 94980 gccagtattt tgtattgtca gacttttaac tttagcaatt tctaacgggc atttggtgga 95040 cttaattttg atttttctgt tgattaatga tgtttcatat gcccattagc aatttatata 95100 tctttctatg tgatgcatca gttcaactct ctgtccattt aaaatttgat tgtttttctt 95160 attatttagt tgtaagaggt ctttatatat tctggaaact aatcctttgt cagaaatttg 95220 tactgtaaat gtttactccc agactttatc ttgccttttt atttttgtca aagtgtcttt 95280 caaagggcag tcatttttaa tcttgatgga gtacaagcat cagtttttct tttacgttca 95340 tgctttctac atagtatgta aaaataacac aaaaaacaat ataaacagta tagcaaggtc 95400 acaaatattt tctactatat tttattctag aagttttaca gttttaactt tcacacttag 95460 ggctatgatt taagttaatt tttatgtatg atttgaatta agcattaaag cttattttta 95520 ctttgctatt tttatctctg gtttgagtta ggtcttcttc atatcatcca tgtttctatt 95580 taaaatgctt aatatttcct ctattaagct taactatcct aacttaactt aactatccta 95640 acttaactta actatcctaa atatttaggc agccaacatt gggccacata aaacaaattc 95700 ttagagacct ataaagagac ttagataacc acacaataat tgtgggagac ttaacacctt 95760 actgacagtg ttagacacat cattaaggca gaaaactaac atagatatct gggacctatt 95820 ggttcttgaa cacctggata gagttgtaat aactgtttta atgtctttgt ttatatgttc 95880 tatcatcttc ataatttctg ggtcagtttt gatttaattt tttctcttcg ttatgagtct 95940 tattttcctg cttttttatg tttgtatggc agactttgtg aaatttacct cattgagtga 96000 tggatatttt tgtattacta taaatgttgt tgagctttgt tctgggacat agttaagtta 96060 ctcggaaaca gatgggttct ttcaggtctt gaatttaatc tttgttaggt gggattagag 96120 cagctaattt tgtcacgcta ctgaagaaaa gccattatgc atatactact caatgcccca 96180 ttttccactc tgactagtgg gtagagaaac tattcttggc cctgtgaaaa ctctgtaaat 96240 tttctcctct aatccttttg ggttgttctt tttccatcct cagagagttt cctcacagaa 96300 ataccctgat taatactcag ccaaagcctt gagggaaggg agatcctgtg aagatttctg 96360 aatctctgtg taactttccc ctctggtact ctgaccagca aaatgtagct ttctccaaag 96420 agacctgagc agtttgtcag ggattagagt atactggctc ctgagtggtg ttagccaggg 96480 aaatgaaatg ttttgtggtg atgtcaatca attttaaggc atcatttcct cattgtcaga 96540 catatctctc acataggcaa ggaagctcat gtcagctgac tagacatcct ctctccagga 96600 caatggtgga gattccctgt gaatctagcc ctcttggtct ccgtttcctt ttgttgcatg 96660 ccaacatacc cctgcttgat aaaccctctt tcttttgtgg taagtttgta gctctctcag 96720 tcccagtgac attacaatct ttgctaatta gtcatctcac ttggggtttc caaaactctt 96780 tattcacaaa tactgatagt cctatgagtc attcttatat atgagtaatt cagtaatttt 96840 gtgttgattt ttaccagttt tatctcaaag atcaatttca ttgtaaatgt tgtgactata 96900 attactgtga attaagaatt tttgaacata ttcctattta aaaaaaaatc tttgctagga 96960 ccatctatct tatttgtatg agctccttta taatctagat ttttgggtat tatttatttg 97020 ttaatatctt ctagtttgac cttgccctta ttttggttct atttcattgt ccatagaatt 97080 aaaataattt tttttgtggt ggattggtcg gtgaggggag gcagtggcag acagggtctt 97140 gctcttttgc ccagggtgga gtgcagtggc tcaatcatag ctttgtaaca tcaaactcct 97200 gggactccat acatgcacta tgactggcta attaaaaaaa ttattttgta gcagtggaat 97260 cttgctatgt tgcccaggct ggaacagaat taaaattcta atatagtaaa aagtataaaa 97320 tctttacatt tattgtttct tctctttaat gtatacgaat gaattaatat ttaatctaga 97380 gacctgaaaa gcattaaatt ccattttctg gtagattttt gaatatatat tttatttttg 97440 tagacatatt agagtgttgt tccgtctctc atatttttct ccttcctgac tactcctctc 97500 atcacttggc taatccatag cagcatgggg gtgggtccat aatagccctg ttggcacaat 97560 ctgattcttc ctctttgatg atggtttatt ttaatccagt gaccatctga atcaagatgg 97620 cctaattagc attattttcc tgggacttta aatctgggct gtaaaattta aattgaaaac 97680 aaggagagtc acttgaatga ataagatgta atcttaggac actgtagaag agatatctta 97740 gttatgatat cactggggtg ttcagagaaa gaggtgaata aatgaactta atgctcagta 97800 agaagcagaa gtgagaggag gaagggaatt tcctgggatt tttatgtctt ctgcttccta 97860 gttccagtgt ttctctaaaa ccagcctgca tttctgttct tggtcattaa taaaatgtac 97920 ttatatcttt ataataaatt ctctctttca cttactttag ctaaatttag tttatagtac 97980 ttctaattca ggagttttaa ctaataaaga attcaagttt tttccctttt ttgtaataag 98040 tttggtgtaa gctgtcagat ggagtatcca acattcaccc taagagtagg aactagataa 98100 attatatacc accttctggg cagcatatga aggcagttca caaaagaaag aggctgaggt 98160 caaggcagaa gctagttttg tatattacta ccagatctta taatttctaa gacaaaagaa 98220 attaagcttg agctaggtta gaaaaccgtg ggagagactg gttaagtatc aatacctagc 98280 ctggagaagg ggcagacaca aaatggaaga gtaataagag aagactggaa ataacactta 98340 gttaaactag ataatccata cagaatcaat ctagaaagag tctcatgatt aataagttta 98400 gttaatcctt tatttttttc atttagaagc tatataggca tagggtactg gacaaaaccg 98460 gcatatacag cagaaaccaa ggcaaacaca gcccttccat tatggagctc acattcttgt 98520 gggatggaga aggaaggtat taaataatta agtatacatt tattcattca ttattactgt 98580 aatgagtact gttaaggaga accattaaag tttaagctga aggaacttga ccaggtctgg 98640 gtgacaagga atgattcttt aagaaagtga aataaagtat ctttgcatat attttctagg 98700 ccagatgttt aaaatagtag acttgttcca gtgggcatgt ggattttttt ttaaaatcac 98760 tttataatta cttgtaacaa aaactggtag aaatgcaaaa gtgtatggat ttaaatttct 98820 gtgttctttt ttttatgcct ttgacattaa ttttcttctt gaaataagtg ttagtcatgt 98880 gacttaaaat gcagaaaatg atacacattg tctagctttg tcagagggat gcagtgagtg 98940 caaagaatta tcttgcctaa gaaatctaac atcctaaatg gaaaggcttc aaatatcaaa 99000 taaacccgat gctactttat ttgatacctc cttacaccat ttcatttagg cttttctttt 99060 ttctgcttcc taactcacat gctcagactt ctcgaaacct tcaggcactg ggaaggaaaa 99120 gagaacaagg aaactagaag attttaagca tgagctatgc accaggtcca ataggaggtg 99180 cttggccatt ttgggctgca tctttagcat tagaaatcca ttcttttcct caatgatctc 99240 tttatgtaat tctccaacag aacagagctt tctcaccaag gccagggacg tttggagtta 99300 ttgtgtggat ttcagggggt cagtaaaaac ttggaaaata tatatattat atatttctac 99360 atttctataa tttacaatca tatttaattg ttcttataaa cttttatttg taaaaaatat 99420 gtttagctta atgaacaaga cacatagagt tagtttattt tgttattact tgctattact 99480 gtactattta gaaaaggagc ttgtaaatgt caatttcttt tcctattatg catagtttta 99540 aaatgttaag gttagtagag taaataatat tgtttaacta ctcagtatgt tgtaggcaga 99600 ataatggctg acaaagatat ctacctcctt atctctgaat ctgtgaagat gttgtcttgg 99660 cataacctca tggcaagggg gtgtgaggtt gcaggtggaa ttaaggttgc tgatcaattg 99720 acctcagaat aagaatattt tcctgtatta ttgagatggg tgtaatgtaa acacaaaggc 99780 ccttaaatat agaagaggaa ggcagaagga ctggagtcag agttattcaa tgtgagaaag 99840 acttgccagt ctgtcgctgg ctttgaagat gttgatgtta ggagaccaca aacaggtgtt 99900 ctctagcagc aaacaaaggc aagaaaacat tctcccctga agctttgagg aaagtataca 99960 gaaaacacct tgattttagt ctagcaggac ctattttgaa cttcttatct ctggaattat 100020 aaggtaacaa atctgttttg ttttaagcca ctgaatttga agtggcaaca agaaacttac 100080 taatactatc aggtaggaac attagattac ttttattgtc cacacattgt gggccaagta 100140 aataattaag tactttacac acatgtattt ttagttctat ctgactgcag aatatacagt 100200 cttaaccatt gtgctataca acctcttttt taaattaata attcaatgaa tgattgaaat 100260 acggaacatc aagtctgtgc tcatttggag cacatacgaa gtactcagca aatgcttata 100320 aatgcttatc tgaagagtgg ctttttggcc cataggaata ttcagcaagc cagagttatt 100380 ctacctccct ggatagaggc gtcatggctg gagcaacttt gagcttagca cattctatct 100440 gagctgttca ttacattcat catttaagat atactcaagc ctttgagagt ttgtttctta 100500 caattctgaa aatatgaaga tatatgaacc tcctagtaca ccctggtgaa tcatcttaat 100560 cagggtgttt ccctcaaggt attccaaaca gacatttttt ataatatgag aaagtgaaag 100620 catattgaac ctaaggccaa gttatagatt ccctaaaagt aagcatcata taaaacaacc 100680 gatccatttt ttcttcaact ttccaaactt gtttttatcc atttgcttga aatgttttct 100740 ctcttgctct ataagtatgt tttgtgtagt gcctgattct ccctatggta tttgctttcc 100800 attaacttcc tattgatttt cagttgtgtg tacacagtac tgcaggaaca taaactgcaa 100860 acaccagact taaagaagtc cgaactctaa ctgttttatc ttggtgacac agtactacaa 100920 cgtgaatatt acctgtggcc tcttttaaaa aatgtattta aaggcagttg tgacaagtag 100980 ggtcaagtct gaataatgat gtatataaat tacagtggaa aaatatttgg cgtctcagga 101040 tgaaggatgt tcaagttgaa agggcaggtt ggaacagata aagagcagtt tttgaaaata 101100 tggcattaca gaaggtgaag caaagtataa gtcactgtaa aaagaaaggt accaaaagat 101160 gacaaaagtg aggaggagtg ggaaggaagt aacacacagc aagttgatat gacactcaaa 101220 aaggaatacc gtttttgaaa caagtgaaat ttaaagttat cttaacttaa tctgatgaat 101280 aatttctcta acatttaaga gcattcacgt ttttattgtt ttgctttata gtaagctcgt 101340 ccaactggca gcacacaaac cgcatgcagc ccaggacagc tttgaatgcg gcccaacaca 101400 aatttttaaa ctttcttaaa acattatgag ttttgccaaa agcaattgca acaaaacaca 101460 gaactgacaa atgggatcta attaaactaa acagatacag cacagcaaag aaactatcat 101520 cagagtgtac aggcaaccta cagaatggga gaaaattttt gcaatctacc atctgacaaa 101580 ggtctaatac ccagaattta caagtcagga aacaatagat gctagcgagg ctgtggagaa 101640 ataggaatgc ttttacactg ttggtgggaa tgtaaattag ttcaaccatt gtggaagaca 101700 gaatggcgat tcctcaagga tctagaacca gaaataccat ttgactcagc aatcccatta 101760 ctgggtatat acccaaaata ccaaaatagt attctactat aaggacacat gcatacgtat 101820 gtttattgca gcactattca caatagcaaa gacatggaac caacccaaat gcccatcaat 101880 gatagactgg ataaagaaaa tgtggtacat atgcaccatg gaatactatg cagccataaa 101940 aagaaatgag atcatgtcct ttgcagggac atagatgaag ctggaagcca tcattttcag 102000 caaactaaca caagaatgga aaaccaaaca ttgtgtgttc tcacttgtaa gtgggagttc 102060 aacattgaga acatagggac acagagaggg aacaacacac accagggcct gttggggggt 102120 ggggaggtga ggggagagaa cttagaggat gggttagtag gtgcagccaa tcaccaaggc 102180 acatgtatac ctatgtaaca aacctacatg ttctgcacat gtaccccatt tttttttgga 102240 agaaataaaa aattgtgatt tttttttttt tttttttttt ttttagctca tcagctatca 102300 ttagtgtttg tgtattttat gtgtggcaca agacagttct ccttccaatg tggcccaggg 102360 aaggcaaaag attgacacac ctgctttata atctcaaaca cagtagcaca ctttgaagat 102420 cagagagaaa acacctaact tcatcagtct tggttgtgtc acctgtaaga cagagataat 102480 acatattaac tcagagagtt actgaatggc ttatgtgtat gtagagaaac tagtaaaggg 102540 cctgtgtagc ttacatatat ttttagaggt gataaaaata accaataacc atatttataa 102600 tatattgaag ttaattgaaa tgaaaaacaa taaattaaca gaaaagatta gtcataaata 102660 aaatgagttg aactaatcaa gcaaaaaaca tgtgtttaat ttctttcaat tattttatag 102720 attttgactg aagtccacag tgctgattaa atttacatct ctattaagaa gcattaataa 102780 tacagaagaa atagacaagc caaggagatt gatggcagac ataggattac tttaagttgg 102840 tgttctatga aaacaatctt aaattaaaat attgaagtgg ggttccttta tattataatc 102900 tcatgtttca caaatttgtg agtgtatgat tgtactgagc taaaattgaa attgaacatt 102960 ttttctgttt tctatatcaa atcgataaca agcaattttc tagaattttg agattgtatt 103020 cctctttcat gagtattttt agaaatggaa ctaagttata aatataagaa aattttgtca 103080 cattagtgaa aaatgtttac ataaaagacc tgaatttcgt gaagaacctt taaacaatgt 103140 tcatctccat aaacacaatg tctgctctga aacttctttc ttattagagc caggaaataa 103200 agaaaggtgt atttttggag gaaagataaa ttgcctgtga tatcttagct ttatgccttt 103260 ttttcttata cttcatttat actaatgaga attttctatt tatcttttat gagttgattg 103320 tttgaaacac tattttgtta tttttaccat attttgtttg gggtattcaa gactcttaag 103380 caagaagttt agttactgaa tattttatat tgatctagtt tcttttcttt ccaacataaa 103440 gttattttta attttttaat ttttttattt ttattttttg agatggagtt tcactgttct 103500 tgcccaggct ggagtgcaat ggcacgatct cagctcactg caacctccac ctcctgggtt 103560 caaatgattg tcctgcctca gcctcccgag tagctgggat tacaggcatg caccaccatg 103620 cccaattaat tgtgtatttt tagtagagac ggggtttctc cgtgttggcc aggctggtct 103680 caaactcctg acctcaggtg atccacctgc tttggcctcc caaagtgctg ggattacagg 103740 tatgagcttc aagtacaagg aaataatgct cagttgagac tgagttgggc tgagtgggtt 103800 tttgattaac tgtggtctgc ctgaaacaga aacagtgctc tctgtagcaa atgtatcttg 103860 aaggactgac agctatacct cctgttgttc tgttcctatt cttacactag tttcataagt 103920 atctataaga taaatagaaa attatcatta gcataaatga tatataagtt ccatttctaa 103980 ataaacaaat tattttaaaa gaagaagttt tttttttatt tattgagtgc ctattttccc 104040 agtcttaccc tcttccagga atgtactcct agttgggaaa aacatcgcct cttgataggt 104100 tacttgatat tgctatagta ttgaggtctc cttctagatc atggttcagt atagcaggtc 104160 atcatttttt ctgactggtg aagagaaagt ctagattttc aagtaccttg gaagagaata 104220 gatatgctac cacctgtggt agtcctgtta tttgatcagg gcttagctct tttcaaagga 104280 actttcctta agaattctgt ctcttaatac cacttctctt gatgactggt tcaccttcca 104340 tgataccgtt acatcagagg agagcctgga agaattgggg tggattttgt gtgcatgtgt 104400 gtgtacgtga gcagtgcatg attcttattg gcttgtttcc tcataattca gctaaaggaa 104460 agcgtatggt ggcgttgatc taactggtgt ttattatcta ccttatattt ccaagaaatc 104520 agaatattct cttgagttcc atttaccaaa gtaagtttta aatcatccta atatagagcc 104580 aaaacatagt tacttttcaa aattgcaatt ccataaattt tagctttatt ttccaagatg 104640 agagaaacaa tagaggaaaa ttctcactca caacctaact cagttatcaa cagaacattc 104700 aaggctggat ctcctaatca acattgaaaa agtatcccct acattaggaa aatactctgg 104760 ttctgtcttt acttcatact gggttattca cagattggaa aggtatataa gtatggcgat 104820 tgaatctatt cccttcccca catatccctc cctttgtagt gaggtcaagc ttggctcttt 104880 cactgtgttc atgtcagcat tttgtgttag aaatttacga tgggtgtggg ggcattacag 104940 tgcattcaac atttttttca gtgccttcta tttggaaata tggtgacatg tgcagccagc 105000 actgagtaaa agttttaatg ggaggggaaa ctagtataag gataggaaca gagcaacagg 105060 aggtgtagcc gtcagtcctt caagacacat ttgctacaga cagcactttt tctgtctcag 105120 gcagacaaca gttaatctta agttagaaga agaaagaagc agagctgatg caaaaaaata 105180 tatatatatg gagaaagtta agctgaatgt tgtagagcta acactcaata agtatttgga 105240 atgttagcag tacaaccttt attagcagct acaaaaatca gactacatag ttttttgata 105300 acaagatgac caattcaagg tgatacagag gcttgtgctt ggagaaggat gtcttgtaga 105360 ctattgacca atagggcaga atttcccttt gtacattcat ccctgttcag gtctaacttg 105420 catcctttta agcacggaca cctgacccat cacacccgca aaagtggata agatcaatct 105480 caagcagtga acttacactg accaagcaca caggaaatgc atataaaagt agattcctca 105540 aggccacatc tgaccagagt attcattatt tgttacagaa gactcgggaa agcattgaat 105600 ggctatctta taattgtttt ttcctcccca tctgaagctg cagacaccat ttgaaaagtg 105660 gctacatccc agcctatgat tgttctcagg tggcattttt gtttttattt tctaaatctt 105720 gatgggtacc tcactgttat tcccacatat cactcataat atttatatta tatactggta 105780 attgaatgtg ggttccatat tctacattca tttgctagac aaataattga gattctactg 105840 tatgccaagc actggagtaa tctgttaatt ggttaattca tttattagtt tctttaagac 105900 atactgtatt tactatgtat tggggactat gttagaagct tgaaatatca cagtgaacaa 105960 gttagaccat ggctactttc aaagtgtcta tagaagaatt gagaaatcaa gtgaacaatc 106020 acaatacttc tgataagaga taacacagag gaggtaatag ggttttattt ttaaagaaca 106080 atatataaat atagtggctt tggtcttgta aaatttagtg gcaatgtaat tgtataaaac 106140 aagggaaccc aagtggataa ggtaggaaat caaaatatta gctagtagta aaataattaa 106200 atgacattct ctggtctgga aattttgcca agtcttttca aataaacgaa gaaaacaaca 106260 aaaaaaactt actttggttt gtttcctaac aagtcaaaag gaaaaccaca atccaacaac 106320 aatgcaagca acagaaaatc tttaaataat gacgctgaaa ttatcttata actttaataa 106380 gtaaaagtaa aaatatggaa ataaacagaa gtttggcaga aagaacagat acaaaaattt 106440 caaaactcag gagaaaaagt cgagatcttc atgaaacaaa gctttaaaag agaaaagtta 106500 atgttagaaa accacacaaa agtctaaaag cttagaatgt tcagatccct aaagaaataa 106560 ggagagcatc atatagattt tatggggcat tttattttca caatagttga tactgaaagc 106620 aatttttttt ccaaagagaa tgtgccacat aacaactagt aaaatagcaa aaacaacagg 106680 caaaattgga taaaatactc cactttctag cagtccagga gttggccctg taatctgtct 106740 tctagttttt aacttagccc atccctgact gtctcatata acaattggtt tgtagatgat 106800 cccatcattg agtagtttag cgtctctgaa tcataggcca ggtacagcat tcaaacttac 106860 ctaaaaacat cactcttttg gttcttaaaa aatattttgt gaaggagatg ccacaagctt 106920 tcccttagaa gccctgtgga aatcatctaa ctggtgggct attattagac acattatcaa 106980 agtttctgct tttttacaag tctcttctta atacagtact agcacatgat gccaacagcc 107040 catgttatta tcatgtcatt ctagtgcttt aactaatagg tccctggaag gagaagaatt 107100 cgtttattcc tttgggatta tatatagatt ttctttctta attttatcta cagtgtaaac 107160 ttatacccag atcatgtctt ttattttgta ttttatgtag caccctcttt gcctttagaa 107220 aaggtttaga agagacaatg aggaaagata gtttaagggt ggtagaaata agttgaattt 107280 gagatttgag atggatgtga aagggtttgg agaggtagtt gctgaggaag gggcaaagct 107340 gggactttgc ctttggagca ggcttcttgg acatgcagaa cagtatcttt gtcagagaac 107400 attctggacc aggaaaactg ggaacattaa tctagattag tacaggactt tgaacatagc 107460 tgtgactacc tgacttgtaa attggcatat ctgtattttt ctgctgtcct gagttagtta 107520 acttcgtatt ttaaaatact catctgaata tatctgctac ttttgcccac ccagaaccca 107580 ttaccttttc ttcagtgcag cactgttccc tccccacctt ctttggaaaa cgatgctgct 107640 ccaaccttta gggcttttgt tttggaaggg cagaccacca acctagatca agatgtagct 107700 gtcgtccagg cctacccaat gaccttattc aatttccata cctacaaagc atggttgaga 107760 agaggaaaaa aacccacact tttcagaggc aatcctaggt ttgaactttt gaaaaggagg 107820 agctctttcc actgtggtag ttgaaggtag agggctgcct ggagctgcca gtagccatct 107880 tgccactctc tgggataagc ctgaccgaat aaagtccaca cagaggaaag cagaactgag 107940 agaaagagag ggaccaagtc cctactgatc tcatttgaca cactcgatct actgccttct 108000 gaacatttct tgagcctata gattactcta cctcccttat ttcccataag tcaccatgac 108060 ttgccttttt ctgttacaac caaatcagtc ctaggaaata aaatgtttgt tttgcttcca 108120 cacccacagt ggggcttggg agcatctgta tttcaaagct gagaattctc cacagaatcc 108180 agttcccttc tatcttgttt taccttctga ggagaggacc atgaaggcag cgtcaggcac 108240 acgacacaaa tggcagctgt gtttcatctc ttctgtgcag atagcttaat aataaatacc 108300 tccttccctt tttagggaac aaaatagttt tattttacat agaaatttct tctgtagtga 108360 gtagcagtga aacgctaata tttattaaag agaaattgcc actgataccc tttggtgtag 108420 cccaagagga tgtaagaaaa aaaggaacaa atggcaccta cactctataa gctgcctaag 108480 tggaatctta atgtagaatt tgttgctttg tagtcttctt ttttttttta tctagcaaga 108540 ctagtgttac agaggatcac ggacattagt cacttgttct tgataacctc tgaagagttg 108600 gataaaagaa agaaactgcc cccagtgaaa agggatgatc tgcaatatct gaagaattat 108660 ttctgtggaa gacaatgtta ttacaagaca ctgggatatt atgactattt tggtagctta 108720 aagaaaaata aattcataat actagatatt aattatattc gatgatatac ataatttata 108780 atactaggat agaaaaaatc tttattaatt ttcaagtagt tacatcattc tctcctcact 108840 tcttagcatg aaggccattt atgtactggc aggtaaatgt caggttgaga aggctctaag 108900 tcatttcaca gtagggaaag ttggtttttc aacttggaag caaattttat tttattattt 108960 ttagaaaatt atatatatat ataacttaaa atggaaaatt gcacaaatca taagtggaca 109020 gctccgtaca ttctcaccaa gagaacatat caatgtaatg aacacccaaa ttaagaaaca 109080 ctacatgggc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc 109140 gggtggatca tgaggtcagg agatcgagac catcctggct aacaaggtga aaccccgtct 109200 ctactaaaaa tacaaaaaat tagccgggcg cggtggcggg cgcatgtagt cccagctact 109260 cgggaggctg aggcaggaga atggcgtgaa cccgggaagc ggagcttgca gtgagccgag 109320 attgcgccac tgcagtccgc agtccggcct gggcgacaga gcgagactcc gtctcaaaaa 109380 aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aacactacat gattagctcc ccaatatcct 109440 ccattcggct actgtctagc caattcccta ccaagggcaa ctgctacact gacttctaac 109500 actgtaaagt agtcactggc agagattttg aaaggcagta tgtcctgctg aaatgtgagg 109560 gaaattccac tgatgatttt aaacctaaaa cgatatgaat atctttagca acaaaaccta 109620 ctttcctcca gaccacataa gaacccgccc atgcctatgt cctatttcct ctggagcatt 109680 tttaggttaa gttttagatc ttgtagtctg gtgatatagt acattttgac ataacatgga 109740 gtaaggatgc catgaggatg cccagctcat gtagggggtg cttggctggt ctgtgatagt 109800 cactgggaga aaggtttaag ggaagggctg gcatgtcatt tccttctccc tcttatcctg 109860 ctccataatg atcaccactg tttattcttt aaataagtga aaagggaaag aaataaatgt 109920 gtcatttaaa gggttccaat ttaagtctcc tgctttattc ttaagccctg cttaatcttt 109980 cttgattcta ccctaaggag tacaaatctc ttttggctga tccactttcc tttgaggaac 110040 caaaagtgaa cacgagcaaa cagattaaaa gatagcccaa gagcactggt caacatgtgc 110100 cctgtgtggt tggatcaagt agagggaaac catgatttgc tttaaaagaa taacggtcat 110160 tgcaatgtcc tgcttctgtt ctggggttca gaatgtgata ttctgcatcc agttaaagga 110220 atctcttggc catttaccac agctaatagt aattaacaga acctactgaa aatgcagatg 110280 caccctcttc aaactagtaa gtgttactca tcatgctggg atattgagag agatttgact 110340 ttgagaagca tggagaaatg atttggttta aaactagaaa ctctggatta tacagatact 110400 catggcacta agcaaattca gaattaaaag aatgtgcctt cagagagaca aatgccacag 110460 gatctctcta tatgtgaaat ccagaaaagc caaactcata gaagtagaga ttagaatggt 110520 ggttaccaga aactgagggt ggtgatggtg gatggagaaa ggggagatgt tggttaatgg 110580 gtacaaagtt tcagttaggc agtaggcata agttctggtg atctcttcca tagcacagtg 110640 actgtagtta ataataatgt attgtatatt tcaaaattgc taaaagagaa gattttaaat 110700 gatcctacca caagaaatgg taaatatttg aggtgataga tatgctaatt agcctatcag 110760 atcattctgt gatatataca tgtattgaaa caaccttata cctcacaagt agatgcagtt 110820 attatgtcag ttaaaaataa aactaaaaaa aatttttaaa agaatgtgcc ttaaaaaata 110880 ttttgttctt ttcattaaat aataatctta gtaacactga cagtgagaat ctataaattt 110940 agcaatttcc aaagcaatca ttttaattgg atttaaaagg gatattatag tggataaaac 111000 cctcagaata ttttatgtag tagtgccatg gtttattaaa cagaattcat ttaaagtaca 111060 catgcaacac atcccgatag tttcttacaa accttgaaat aagcaattat tgagaagagt 111120 tgagagggtg attttctgag tttaacgaag aaggccttac atctagaagc ttgcagtctt 111180 cttgaagata gagattctga gttggttttg gctcagtgtc acccttgcct gaaatagtat 111240 gtggaaagcc acaataatgg gaatgagcat agtgtatctg ggggaggagt agacaggtca 111300 gtccagctga atgccgtgta tgtatgtttg tgtttgtgtg tttatacacc aagtgtaaaa 111360 taaaataaag tacaagtcat aaaattggac atgttacgga tagttttgta ttgtcataaa 111420 cacatttaca ctcaataaat gtggaacgaa taaatcaaag gacaaaaagc tttgaatacc 111480 taatggaacc tgagggtgtt catcctgaag gtaactagaa gatataagtt atttctctct 111540 ttgtggccag aaaggctaga attcctttta tagacagagc aatgttacta gttttcagac 111600 agatgggaat tgaaacaact tttatcttta aagacaaaat cctacccaac attgtacata 111660 tttaaattta tgtgaagttg cccacaggca gtggaatgag ttaatcaaat gataaagaaa 111720 tgtcaaaaca tcttatactt gtatataaac ctggtagttc agtatcctat aaagtacaac 111780 caatccatct gtccgaaagc ctaataccac tatttttggt gacactaaat gctttaaatt 111840 ttgtcagcaa gatttgaggc aatgtcaaat gctagagtga tcaatatcaa atactagagt 111900 gataaaaccc caatattatt atatataatt atatgtgtgt atgtatataa atatatgcca 111960 aaatgctata caaatctata cacactttat ataagtacta tatgcacaca tacacacaca 112020 taattattaa ctaagtttaa aaaattccac gtgatgagat ttttttttaa ctttaaaaag 112080 tattagctca ttagacttca cttttttttt tttttttttt tttgagactg ggtcttgctg 112140 tgtcgcccag gctggagtgc agtggcgtga tctcggctca ctgtagtctc tgcctcctag 112200 gttcaagaaa ttctcctgcc tcagcctcct gagtagtgag gattacaggc taatttttgt 112260 atttttagta gacacagggt ttcaccatgt tggccaggct ggtctcgaac ccctgacctc 112320 aagtgatccg cccacttcgg cctcccaaag tgctgggatt acaggcatga gtcactgcat 112380 ctggccagct cattagactt cctgataaga tttcaaattt tatgtctttg tccgaagtca 112440 gatctataac tttaaaaata taaactagtt attttacttt gttttcattt gtttttcttt 112500 ctgatttttt aagtaattaa ttctaacaaa atggtctact tggctgtgct catgtgtata 112560 gctgatgtca gcatattaat agccagatgt agatgacata tcttgatctc tggtctcatc 112620 gctctactgt taccgtcaac attgttacca agcatgagct gggcaatgca aggcaattat 112680 tttctgaccc ttgcagtctg tataatttgg ttatccccta gatacaatct ctataaatag 112740 tgtttgttgg gttctggaaa ctagagtgga cagatggcat gggggacata atcaccaatc 112800 ttacccaagt atgtaacaga tctgagtata taaagaaagc ttgggtattt cttgtagtca 112860 gcatgatatt ttgctcataa atttccaaca taatataaat tttgaaacaa aaaggtaagg 112920 aaaataaagc tttaggactg ttttcagcct gctatttttg aggaacaagt gacagagtct 112980 ggtcatcatt ccattctgta tctttggatt attttaatgg attatgtccc agatggatat 113040 tagcgtattg gtagggcatg ggcagctaag tggtcaaaat ttttaaaaag cagcagctac 113100 tggattggct tgaactgttt ccttaaaatg gcagattagt tttaccagtg gtgtttttaa 113160 tacagcttca catcaaagca gatttgtgta atttggccac ctgctataaa catcaatttt 113220 aatcaatcac atatatcttt gccaatatag tttatcagtg gtaaatgttt aaagattttg 113280 aaataaattt tatgataaaa ttaagcagcc atctggaatt gtaatatagg ttttttctaa 113340 atgatttgca agtcataaat tttaaacact atatatagag aatacacaca gtaagtgtac 113400 attcattttg tccctgttta caatattgtt tttgaggaca tttcattgtg aataatacag 113460 aaaatttacc ttctgaacag gacctatcaa cagtcttggg cagaaagaca tttgagctct 113520 gctggtctag acctgtgtgc ttagataatg agtccagcta ttcttgccag aactgcttgg 113580 tgattatgat tcaatctctg tagcttttca gtcagtgtga aattattgta aaaaacaaaa 113640 tctgctctct gatacattta tttcaagtgg tattgcttta ataatgtacc cccaatccaa 113700 gtataactta caagaaaaat gtatttagcc tgcatatgca agttagatat cctccccatt 113760 agagtagtaa cttcccaaac tgtttaggaa agatgcatcc aaagaatttg cataattatt 113820 atattgcaat ctggatttgt gaaatcaaag gtattggata tctaaattag taggaatatc 113880 tgcacacaac ccctcaatcc acttatttca ttacatggct tattttaggt tttcttttct 113940 taggcttatt tttgaataat tgatgtattc attaccagta gtaggggatg tgggggttgg 114000 tttttatctc ctctgtttta tccccctttt tatacttctt ttattgctca ttttaacatg 114060 ccacctgtgg gggtttctcc ttgacgtaac tagtattctt ctggctaagg ccatatttta 114120 ttagttttat ggcttgtctt tccttttatt caaaatctca ggtcttgaaa aagactggat 114180 acgaatgtaa aatgtaagaa agaacaaaaa tacactttaa aaagactttg gattgccaat 114240 ataaagtcca ttattagcat tcataaaata aactacttta gagccaataa ggatgaaatg 114300 ctctactttt aatttctgtg gcactattaa aaatactgta tatgggatac atcctacttt 114360 atagggatta actttcaaca tgcaaataaa caagaatcgt ataaccagtc ttacgtattt 114420 aagatttaat ctaaaattaa aatattttat atatttgatg tgtatcctta ggttatcact 114480 ttatgtagat agatgtggaa gtccttaata cttaacaaaa cacatataat aggctgggta 114540 cgtacctata tcatctgata taaaactcct gtgaggtaac tagggctgac tctggataac 114600 aagctatcat caatatacca cagtacttct cacataagct atatttgtga cacagcttga 114660 tgtgtggtat aatattcata gttatgaata agcatatgtt tggataatac aggaggatgc 114720 aactcgctct tccttgaata gtaatgattt cacagagaaa ctaatattta tattgggaca 114780 cgaggaatgc ataggaattt atccagtcca atttaattat tgtacaacga aagttaaaaa 114840 gagaaaacgc cattgacttt ggaaagtagg aactccagct atgaaagttg gaggtgaaga 114900 gtattccaac aaaaagagta gtatgaaata atatagtcag ttaagggaaa gccaagaaat 114960 tgaagttcat aagattggga aggtaaacaa aatggtggag aagtagagta aggggcttcg 115020 aactcatcta aggtcaggtt atcaagggca ttattgccaa gataaggaat aattctgcag 115080 gcatagagag ctagccaata ttttaaagcg ataagactga catcagttta tgacttttat 115140 aaagagatta tcaacttata ttgtggagat tgtaccaaac aggaacagat tgatagcagg 115200 gccaattata caaaaatgat actgatctat tattttttta gcagaaaagg aagccatggg 115260 tttttctagg aagagctctc ttatatgtaa ctaattagca ttggttttac tgctagatta 115320 caataaaata tataaagatt agagaatatt gttcatactt aatttttttc attttttatt 115380 ttcaacaaga cagtttatca agatagttta tataatgatt tgaatacatc ttcatttttt 115440 tcatactttt taaaataatt tttttcacat gttcaagtta ctgttcatcc atgtggttga 115500 cagaggccca tgaggttgat aaatgaactc cactgtaacc aaaacaactg tttttaaaaa 115560 taaatacatc tcctttacca agattttgaa gacatctgaa agcaaaagca attgatctgt 115620 tttaccttcc ttacctgaca cttcctgcaa agcaaacaca atgtaaattg ttagaaaaag 115680 attcaaaagg cagctgactg aaaagaaaag gtgaagaaag tacataaacg agcaacacac 115740 caaatgacaa tttaattctt gtacaatgaa agttgaaaag acaaaatatc attgactttg 115800 gaaagtagga actcttgcta tgaagattat tattactcat atataatgcc tttattattt 115860 attctgtctt atttatactg ttcaaaatct ctactgtgat agattatgaa acagagaata 115920 ttcttgtgcc tggaattgtt tgtccatgtc aagtattgtt tgatggtttt gacttgattt 115980 gacaagtcag gttaatcaaa acaatcaagg ctctatacca tatctagtct cattatactg 116040 tcaaaattta gatgttttgt aatagtaaag catattaatt gtttgctgca agaagttcag 116100 ggtccttagc tgtccttcta gcatggaaaa tgttgttcat tttagtgaat atgtaaagga 116160 atagttgggt taacttttgg gcaaagcaat ttattttctt acttaatgca agactagtac 116220 taatgattct tgtaacaatt gtcataaaga tgattcatat ttttctatgt ggctttataa 116280 atgcaccatc tatcataaga tagaagattc tagtttaatt gctaacattt atctttttgg 116340 gtctcatttt ccccctggag taacatttct agaaatgata aaaaaaatca ttacttaaaa 116400 gattgggctt taaaattgga attcaaggtt attagataca aatttctgtg ggggaggaaa 116460 gcacatgtat tatcctaagt tatatattat tttgtctgtt aagccattga tataattaag 116520 gggttaattg ttacaatcgt ctttggagat caaagtttag attgaatgag caattgaaac 116580 ttgctatgtt ttaaatgtaa gaaaagtagg aatttgcttt acagttatcc ttttaaataa 116640 gaccttacag gagagttctt ttctgtcatt ctccctctct tgccctctgc cttctccaat 116700 ctccattact tcccttttgc ctcttttccc tccacaaata tttattgaga gattactgaa 116760 tgagtacaaa atgtattaat gtagtgacaa atatattgct gtacaaacaa atgcaaaact 116820 ttcttagact aaaatactgt taaggttagt tttgagcaat atttgaagaa ggaaagggct 116880 gcagtgttgg agggaagata tcaagagtgg acagtaacta catcaggata aaactgacca 116940 tttaggagca agtccaaaag cccaattagg taaaaggagt cttagaggca tggtagcact 117000 ggcaggcaag aagtcatgtt caagctagca gagggggaag ttctattaga tgatgactca 117060 agtaaggaaa taataaacta cagttctagc aggctttcat gagggaaaat tgcatggtac 117120 agaaaggggc attggcaatg agaagggagg cacaagcagt gttgggctat caaagaggat 117180 agattcattt taagagaaac caggtcactt tggcttcaac agtaaacatt ggttggtcca 117240 tagagtggat aaacaaacag agtgaacctt tgtcaaaaat attaatttaa attgtttggt 117300 tacctgctac tgttgttgtt gttttgaggg gagattatgg ctatcatgca atcaaaatag 117360 tacctaaggg ggacaatttc agagagcata gtgattaaga gcatgtactt tggagtcgga 117420 ctgcctgaat tcaaatccta gtttcactat ttacaaactt tgtgactttg ggcaaattat 117480 ttaacctctt tgtacctcag tgttcttata tttaaaatgg ggagaatagt agcacatacc 117540 tcaaaagatt gccataaaca ttaattgaaa tatttgtaaa gtgcttagaa taatacctga 117600 ccaatagtaa atggttgtta agtgtatatg tatatgagtg tgtatatata tatgtgtgtg 117660 tgtgtgtgtg tgtttgtgta ataaaggctg tatgcttgag tagctcatga cagaaatggt 117720 aaacactacc atttaaggga gcaaaagaca aatgtatggt aatgtttgaa cttgaagtaa 117780 agcttgcagt atgtaaagga tggagtggat ctagagttta tttattctgg ttttaccagg 117840 ccaatctagc atgttcttgc ccaaacatgc taaattagcc tagatgtact gttagttcag 117900 ccaggtaagt attaaaaggt ctaaagtttc aaactcctgc tttagggaac aaggactatt 117960 gagattccaa actactctag agttagcaaa attggaccaa gcttctcttt ctaggagtct 118020 tgagaatatt cagggctaga aaccttggtg cttctgagaa caccatacca catagtctac 118080 ataaatccag actccaaaca aacatgtcaa atacaagacc ggaaaggatt ttagagctgg 118140 ttcagaggct gttacctgta ttttgctcat tcatgaattg ctggcccttg tgattttttg 118200 tgggtggcac ctgggacttt ttgacatttg aaagtctctt tcaatatttg catctatgat 118260 gcatccattt ggaaagtcct aaaaatatga agatattttg tagaaatttt aggatgatgc 118320 agattaagaa acggttaatt tatggaacca aaaaagagcc cacattgcca agtcaatcct 118380 aagccaaaag aacaaagctg gaggcatcat gctacctgac ttcaaactat atacaaggct 118440 acagtaacca aaacagcatg gtactggtac caaaacagag atatagacca atggaacaga 118500 acagagccct aagaaataat gccgcatatc tacagctatc tgatctttga caaacctgac 118560 aaaaccaaga aacagagaaa ggattcccta tttaacaaat ggtgttggga aaactggcta 118620 gccatatgga gaaagctgaa actgcatccc ttccttacac cttatacaaa aattaattcg 118680 agatggatta aagacttaaa tgttagacct aaaaccataa aaaccctaga agaaaaccta 118740 gacaatacca ttcaggacat aggcatgggc aaggacttca tgtctaaaac accaaaagca 118800 atggcaacaa aagccaaaat tgaccaatgg gatctaatta aactaaagag cttctgcaca 118860 gcagaagaaa ctaccatcag agtgagcagg caacatacag aatgggagaa aatttttgca 118920 atctacttat ctgacaaagg gctaatatcc agaatctaca atgaattcaa acaaatttac 118980 aagaaaaaaa caaccccatc aacaagtggg cgaaagatat gaacagacac ttctcaaaag 119040 aagacattta tgcagccaac agacacatga aaaaatgccc atcatcactg gccatcagag 119100 aaatgcaaat caaaaccaca atgagatacc atctcacacc atttagaatg gcaatcatta 119160 aaaagtcagg aaacaacagg tgctggagag gatgtggaga aataggaaca cttttacact 119220 gttggtggga ctgtaaacta gttcaaccat tgtggaagtc agtgtggcga ttcctcaggg 119280 atctagaagt agaaatacca tttgacccag ccatcccatt actgggtata tacccaaagg 119340 attataaaac atgctgcaat aaagacacat gcgcacgtat gtttattgcg gcactattca 119400 caatagcaaa gacttggaac caacccaaat gtccaacagt gatagaccag attaagaaaa 119460 tgtggcacat atacaccatg gaatactatg cagccataaa aaaggatgag ttcatgtcct 119520 ttgtagggac atggatgaag ctggaaacca tcattctcag caaactatcg caaggacaaa 119580 aaaccaaaca ccgcatgttc tcactcatag gtgggaattg aacaatgaga acacatggac 119640 acaggaaggg gaacatcaca caccggggac tgtcgtgggg tggggagagg ggggagggat 119700 agcattagga gatatatcta atgttaaatg atgagttaat gggtgcagca cacccacgtg 119760 gcacatgtat acatatgtaa caaacctgca cgttgtacac atgtacccta aaacttaaag 119820 tataaaaaaa aaaagtagga atcaggcaaa aaaaaaaaaa ggttaattgt cctgttgaga 119880 ggttgattca gattttctgt tattctaggg ggagagttct attgatgaca aaaatgtaaa 119940 tttctttcta tgtcattttg ttcagtctgg ggagtagcaa aggattattc tttacagtat 120000 gttttctaat gatttgtcca aactgatttt gtattccaga atcacatact gctcttgggt 120060 ttttctcccc acatttccct tcagtggatt atttatactt ttaacaaaat gatgaatggg 120120 tcgttgtata ttcaaaatgt gttcacttcc cctggagaat ctgagtgaaa caagtacatt 120180 cttgcagaag aatcctaata tggttaccta gtcctttgaa attggtttta tctttgattc 120240 tgagaattct ctacaaattc aatgctgtat attaaaaagt tacaatattt catattttta 120300 atagcagaga taaaattgta gaaacaagtt ataatagaga aaagatttta gtttcttctg 120360 gagagcagta tttcataaca taaaataaat ccacttaggg atttatagaa tattttctct 120420 acatattact atgaaacttt taagacataa tttttttttc tctttcctgg aaatcctttc 120480 tctctcttcc tctctgttgc ccttatctat cccccacccc attattgtac tttagcactt 120540 aagcatttaa ctacagtttt gaccaacaga tgtatctgtt tgtttccata tagtaatata 120600 tgtttatttt agagaagaaa aaataagaca aagtaaaaat atacagcaac tgaggcacaa 120660 aattctgcag tgacttgctt catttttccc ttcctattta atcaaagtac tatcaaaaat 120720 tctatttaaa tttctcaaat tagaatatag gaaatatcat tcagatattt taaaaaatgt 120780 aattatatac ataagcataa gtaatagtac agaatgttgc atgagatgaa aatgtatata 120840 agcttagctg tcattgatca tactgaaaat tatttctaag atggacttta ataggctaca 120900 gatttttaag atttttaaaa ttgtaagctc tgatcaaggc actgtgttac ttacaggggg 120960 atgtatgcat gtgcatgact tggtccatac tttccagaaa tttataattt agttgaagag 121020 aaaagaagta gacaccatga cgatacaatc tagtttgtga gtggcacaga ttttgctata 121080 gctcagaaga ataaaggcat ttttaaattt caatagtttt tggggaacaa gtggtgcttt 121140 atcacataga taagttcttt agtggtgatt tctgagattt tggtgcaccc atcacctgag 121200 cagtgtacac tgtacccaat gtgtaatctt ttctccctca cccccctggc actcttcccc 121260 ctgagtcctc aaagtccatg gtggtattct tgtgatgcct atctcccact tataagtgag 121320 aacataagat gtttggtttt ccattcctga gttacttcac ttagaataat gatttccaac 121380 tccatccagg ctgctgcaaa tgccattatt ttgttccttt ttatggccga gtagtattcc 121440 atgatacaca aacacacaca cacacacaca cacacacaca ccacacacac acacacacac 121500 acaccacatt tcccttatcc acttgttgat tgatgggcat ttgggctggt tccatatttt 121560 tggaattaca aattgtgcta ctctaaacat gcatgtgcaa gtatcttttt catataatgg 121620 cttcttttcc tcttgggatt cctggatcaa atggtagact tacttttagt tccttaagga 121680 atcttcatac tgttttccat agtggctgta ctagtttaca tttgaccagc agtgtaaaag 121740 tggtcccttt tcaccacatc caagccaaca tctatttttt taattttttt aaattatggc 121800 caatttttgc atgagtaagt tggtatctca ttgtgatttg aatttgcatt tccctgatca 121860 ttagtgatgt tgaccatgac ctattttggg ttcaagtttg gctttgggaa gtgctttgga 121920 gcttcttctg agtccagcca ctgagctggt catcaacagt tgtataaaat ccacttttca 121980 ttgcatgtca caattcgatc tagaaatggt ttgtcgtttt tgtgttgaat aagagaatat 122040 gacacttcca aatgacattt ttttaaattt tcagtcagct catgaggcac tcacttactg 122100 agctttttca cctttccaat ttgcttcaaa tgccaaacga ccatagaatg gtcaatgttg 122160 agttcttctg caacttcttg tgtagttgta ggaggattag cttcaatgat ggctctcaat 122220 tagtcattgt caacttctga tggctggcca ctatgcttca catcttcaac actctcacct 122280 cctttgcaaa acttcttgaa ccaccactgc actgtatgtt cattagcagt tcctgggtca 122340 aatgcattgt tgatgttgtg agttatctcc actgctttat gacccatttt gaactcaaat 122400 aagaaaatcg cccgaatttg tgttttgtct aacatcattt ccatagtcta agataaatct 122460 aaaataaaca gcaagtaagt cattagcaaa acaacataaa gcaagaaatg cacattaaaa 122520 tgatgtataa cataacaaca cttatttaag actgtatttc aatatcaaac agcaaatttc 122580 aacaatgcaa aaaccgcagt tatgtttgca ccaacctaat aactgtgaaa tatactttgc 122640 tttaggctgt ttctgtcaat gaagctgact agttacaatc ttactaggtg ctgagaattg 122700 aaaggaaggt gctacagttg acacagatca ccagtcctac actattcaaa attttaaatt 122760 aaaaaatatt tattgagtag tttttatgtt caagggactg taaaagacaa tggaaataat 122820 tttctagaag agtaaaaaac agttttgtct ccaaaaattt caccatccac attcggaaac 122880 aatcaagcta aaaagtcaaa ccaaacaaat caagctttaa tgaaacatgg ttggaggaac 122940 tcagaaaaaa gggtgtctaa ttctgttttg gggtatctgg taagctatga ccagaggagt 123000 aaatctcagg ataagtccca aagatagacc aggtaggaaa gggcatttca ggcagaggaa 123060 actttatagg cagatacact gaagtgacgt gaagtagaga atcctaagga aattgcagac 123120 taaatagtag agtgctgatg gagttgtcaa agccatgacc ccggagtgtg gcaaagggca 123180 gctcgtgaaa tgtcttgcac attagcccga agtaaagtgt tttgaagtgc agtccttcga 123240 gtcctgtaat gttagaagaa ataatgctgt cataatccct aaacatatta tgacaagaca 123300 taacacaaat ctatgaagtg ttgtgaaaca ggatggtgca gtctaatgtg aaacaagtgg 123360 tcatttttca ggatgaatct agattccctg gggtgaagga gagtcagagc gtaaatagat 123420 acggaaagtt taatgagctt tgaaaggcaa tctttatcga gtcagaatgt aaaagagtca 123480 caaaatgaat aacacaaatg tattaattta tctaataaat attaactgcc tttaatgtat 123540 ccctgtggga gatgagagtc ttgttcttga gaatttcata acataccaca aacatcaaga 123600 tctttgagtc tgaagaacca aagtaataga attggctgga cgatgttgtg gctacttctg 123660 gccccccagg tgtcttgagt taataatatt gctgatctgg aaatagtagg aaggttaatg 123720 aacaattgca tttcttaatg ttcttgtacg tgtttctttt gtgaactgaa tgttagccta 123780 tttataagac atgccacaaa gtgatctagt aggaactttt taagctcatg ctacaaactt 123840 ggggttgtga aaactaaagc aaataagttg gtatttttag tatgtaatga aaggaggaaa 123900 gttgtggatg agtagaacaa agagataggt ttaacaatca taacacacaa agtcatttgg 123960 tggcctatat ccaaactttc attgattttg ttcatgtttt gtcctagaac cttgagaatc 124020 aggagaatct agtctcttcc ccaacctcag gggtgaagct tgattagtcc aggccagtta 124080 tggtaattcc ataccattgt caagtgactc attctgttat ggacacagga cgacagaatt 124140 ttggcaaata agatatgagg gaaaatcagt tgggtagctt ctgagactgt tttagtcatt 124200 cttatttagg atagaaagat gagaaaatgc ccttttgtgg cttttcagta gtactgcgtg 124260 aggatgtaat atttgaagct gttgcagcca tcttgctatc atgaagggcc agaggatata 124320 gttctacttt ctgatgttgg cagtatggaa gggatggaaa gaacaggagt tatttttttt 124380 ataatggact gaggaattaa ccagctaacc attcttgccc tgccatagct ctaaactctt 124440 acataacata gaaaatgtat ttacaaaatc caatcttgtt ttaattgttt ttcttttcct 124500 tgcagctgaa agcattcttg gggaggaacg catttcttct atcctcttat tttcagtatc 124560 tggaagcctg caaattaaac aaaccacaaa aaaaaaggca gatctatagg aggaagggca 124620 tatatttctt ttcttcttaa aattttattg gagtatgatt gacaaaaaat atgtacatat 124680 ttaatgtaca caactttatg atttcaaaga taagtataca tccatgaagc cagcaccaca 124740 gtctatgcca taaacctatt cattacctac aagagtttac tcctgacttc ttatctatta 124800 ttcttatttc atatgataca aaaaagagaa aataatttaa aaatattgcc acaaagaagc 124860 atcaaaacac aaagatagac aacatgagat ggagagagga acacaataac tgcaaaacat 124920 tcagaaaaac agttaacaaa atggcaatag taagtccttg cctatcaata attactttaa 124980 atgcaagtgg attaaactca ccaataaaaa gacacagagt ggcagaatgt gttaaaaaat 125040 aaaaccagaa tgcaactata tgcagtctcc tttctctttt ctgtatctgc tgcaagtttt 125100 ttctttgtgg ttacaatgag gcttgcataa aactctttat tactgtaaca gtccattttg 125160 actaatgaca acttcaattg catgcaaaaa ctatacttgc actcccctgc cccactttat 125220 taatgtcaga attaacttat ttttgtacta tgtattcatt atccaacttt ctgcagttat 125280 agtttctttc tatgttttgc cttttaagct ctatgctagg gttaagagtg atttacgcac 125340 cctcattact attttacgtt attatgtatt tgtgtatata tttaccttta ccattgagag 125400 ttatgctttc atatattttc atattactgt ttggtgttct ttaatttcaa tttgaagaac 125460 tccttttagc acttcttgca tggcagttct aatggtaata aacttcttag ttttggtttc 125520 tctgggaaag cctttgtatc ttcttcatta ttagaggaaa gattttccag gtatattatt 125580 attggttagc agtttctttc tttcagcact ttgaatatat tatcctattc tctcctagcc 125640 tggaaagttt ctgctgaaaa attcattaat agtttcatag ggatccttcc tatgtgatga 125700 gtcacatttt tcttacagct tttaaaattc tctctttgac ttttagcaat ttagtgataa 125760 tgtgtcttag tgtagacctc tagtctttaa gttccacctg gggttttggg ggcttcataa 125820 atctggatgt tcattttcct tttcagattt gggaaatttt cacccattat ttctttaaat 125880 aaggattttg cccctttctc ttttattttt tttcctgagg tacccataag gtaaatattg 125940 atttgcagga tgttgttctg taagtcctgt aggctttctt cactcttttt cattttttat 126000 cttttcattc ctctgaagag ataattttaa attacctgta tttgagctaa taaattcatt 126060 tttctgcatg atattctgct gttgaaactc tctatagaaa ttttgaattc agttattttc 126120 tttggtggta gaatttctgt ttggttctct tttatgattt ctatctcttc gaggaacttc 126180 ttgttttgct cctgtatcat tttcctgatt tatttatttg tctatctgtg ttcgcttgta 126240 acttattgag tttaagatga ttattttgaa ttcttatcag gcagttcata gatctccatt 126300 tcttcatggc tggttactgc cattttattt tgttcctttg ttgatgtcat gtttccctga 126360 ttctttgtga attttaggac ttgtatttat gtccatgcat ttgaagacat cattttttcc 126420 agtctttaca gactaatcag tccagtcaga gattctgggt gagctggttg gtccgctggg 126480 ggcaggactg ctgttgatgt ctttgggaag gtagcctgta acctgggttt ctgggagcag 126540 gcctggttct ggtttccact gtggtaggtc tggttttggg gtcatgataa agtctaatat 126600 acacttttct ctccctttct tccacaggtg aactcctgag ccaataagat ctctttgggc 126660 agttcattaa gtgggctagg gaaatactaa tgtggaagtg aaaccatcct ttctactctg 126720 catattgtgc cttttctaat ttatgtgctc tatttatgtg ctgcagtctt tcacctggat 126780 tccagagttc ttatcaagat gttttgtcca tggatgtttg ttaaattaat ttctgtggga 126840 tgacaagggc tggaaccatc tattccacca tattgctggt gtcatttccc catatgttgc 126900 tttatttaca ttaatatttt atatgcttga ggtatcagaa aaagaagtgg aaaccccaaa 126960 aggcagttag accccgaggc atatgtacca ctttaatgaa gggcaataaa ttgcagagaa 127020 gaaatcagca aaaaaaaggg atttgggctc ctaggggcag taaattgtga aaatgtgact 127080 agtattgtag ataaaggctg tttagtatgg tttgtcatac agataagagt tgtttacctc 127140 ttccaggtac aggagaggag aacaccttta aaaatggaga cctatgtcac ttttacaaag 127200 gaaaatttat gctgtgattt taggcagaaa gttgacacca gagaattctt cctgctgctt 127260 ctcaatttcc ttcagctcaa aaatgatcct tatgccaata tggaatattt ttggggtggc 127320 atattctgct cctcttcagc atccttcctg gtatgtgaat tacccaactc ttgtgttctc 127380 agaagttggg cttgagcctt ttgttcaggc ttatgggtac attttgtact ctctaggagc 127440 taaagcagat gggaaggtag tttttagcta agatattttt acaaatcata atttttatgt 127500 ctatagtaaa accaaatttt aagcatcatt acagcaaatc tgaagtggat aaatgaactg 127560 ataaattttt aaaaaaatta agatagtatt aagaaattga catgtagatt ctaaactaag 127620 atttaatagc taacaatgaa gacatcttcc ttatttttat gactgctgag agcaaaaaca 127680 caaagaccta aagcaagtaa ttgaaataaa aaatgatgga ttgggctggc agctattctt 127740 tagatataaa actaaatgca gtctgtctgg aatttaaagg gagtgggtga tccttagccc 127800 ttccttcaga tagacatgca agaaatacaa agtttaaccc ttaataaata aagcctggga 127860 gtaaggaaat tcagaaattt gaatcatatg accaataaaa tgtctctttt tatatcacta 127920 ttgatatcat ttgtgtaagg gtttgaatgg catttaagaa cctcttggtt atatgaaatt 127980 gaatttcagt gaaactaggc tgttattttg tgaagtatct gacttagcat tttttaagga 128040 agatatcatt ttaattagtg tatttgaagg tcgagtggat acttttactc tttttaagta 128100 gtggttttct tcacaaactt cggttctgtg tcatatatta ctgatcttta caatgtctct 128160 gagttactgc tgttttccat tcttaaattg ggagaacttt attcctgatt gagaagcaag 128220 aactgaaaat gtcacttttc cctttgaggt gtggaggaaa tcttttggaa atgttcagtc 128280 tctagtttcg taatgtgtaa cttatacttg tatagaacgt taggtcaaaa tttttttacc 128340 agtggcattt ctcacattca ggtgtaaggg ctcgatgctt gcgtagatac aggaaatcaa 128400 actcacaaaa agtctccact tgttttaggg aattcagtac ccagctgaga gcaattacag 128460 gcaatattaa tatgttggca agaaatgtca gagttcaaat ggccagtctg agtgttcact 128520 ttttccttta tttgctctgt gatcatggct ttagaaggtt ttcttgttaa gaatagttgt 128580 gacctcacct gaattgaaag gtggaagtaa tgtttcttat catgtgtggc atggcctctg 128640 gtcaagtgaa aattattcac tcacttggaa aatgtctttg gtacaggaaa tgatatcctg 128700 aaattcatta agggtttacc attgggttgg attctctata tgaagtgatc acagaacttc 128760 aaacatcatt ctatgaataa cagcttccta gggtgcatgg agaaaaactt cattttctca 128820 aatatttatt gggtaccaac acaggagacg ggcctgtact aggttattga tgtctataga 128880 tagttaagga aacttaagaa gtttccttaa ctatctatag tttccttaac tgtacctcaa 128940 ctatatcact tgcagctcat tatgtgtagg tatctctgca tgtatgatct atttccttct 129000 actgctacag actagtagat atcacagttg gcaattctac caaaagaacc tatagtccca 129060 gctactcagg aggctgaggg aggagaatca cttgaacccg ggacacagat gttgcagtga 129120 gccaagatcg cactactgca ctccagcttg gcaacagagc aagattcagt ctcaaaaaag 129180 agagaaaaaa aatgctcctt ttggtttccg atctgtttcc ttagggagaa attgttcccc 129240 tcaagctctc tttctaagag agtggacaga aatgtcttat ctctccagtc ggtaattatg 129300 acttctctgt aagtctacta ctacagacta gtagaaggaa atagatgata catgcagaga 129360 tacctacatg taatgagctg caggtgatat agttgaggta cagttagatg cagataatac 129420 agttgaggta gttatagctg aggtgcaagg gacaaaaatt agacactgtg tgattaaaag 129480 aaaatcatcc atcatctgag caacaactat tcattgaaca cctctaatgt gccaggatca 129540 cgctttgtac aagagttatg atggtgaaca aaatagactt tcagagttta ttcttgaatg 129600 gtaatgtatt aattaaaagg tctcattaat gtttaattac aaactagatt aagtattgtg 129660 gttcaagtgg acagctgggt caggggtgga gtatatctag gatagagaat ttcagttcta 129720 tattttacta attaactggt aaccaggagg tatgttctat acttacattt agctctgtgg 129780 cctgttgtgc ttcaatttcg tcatcttcaa aaccaggaag agctatattc atcttatctc 129840 acaaagctga ttaacataaa tgaaggagcc ttggaaaatg gaaagcatta tacaaatgta 129900 agttgtatag agttccacgg taattgctaa aaatactgag gcaaagataa tcctttgtag 129960 acagaggttt tggttaactt gtgagaatag agttagtaga atgctagaca tagaaaacag 130020 atttcagtga tttcaggaga aaatcagagg gaaggaagaa acatgaggtg ggtccagaag 130080 tggaagtctt caattccttt agaaaaggca catgtagctg gaagcagtgg ctcacgcctg 130140 taatcccagc actttgggag gccgaggcgg gtggatcaca aagtcaagag atcgagatca 130200 tcctggccaa catggtgaaa ccccgtctct actaaaaata caagaattag ccaggcgtag 130260 tggtgggcgc ctgtagtccc agctactcgg gaggctgagg caggagaatc acttgaaccc 130320 aggaggcgga tgttgcagtg agccgagttt gcactactgc actccagcct gtcaacagag 130380 caagactccg tctcaaagaa aaaaaaaaaa aaaacagtcc ccggtgtgaa catggcacgt 130440 gtatacatat gtaacaagcc tgcacattgt gcacatgtac cctaaaactt aaagtataat 130500 aataataaaa taaaaaaaag aaaaagagaa aaaaaaaagc tccttttggg ttccgatctg 130560 tttcctcggg gagaaattat tctcctcaac ctctctttct aagagagtgg acagaaatgt 130620 cttatctctc cagtgggtaa ttataacttc tctgtaagct ataaataggc aaaaaaattc 130680 cctaaggatg tatgcctggg gtgttgtagg ttttagtcat acctgaaagg gttgctcctt 130740 cttccttttt cagagtactc tgtatcgtta tctattcctt tcattttttt tctgaatatt 130800 ttcctaactt attttgtcca catgttctac aggtaaacct taaagattaa attctgttga 130860 ccctgtgctt tcttcagtct aactccttgg cacactgaaa ccacatttga tattgaatgt 130920 tttaacataa tctatttcag gaagtaaaaa aaatcctaga gctctctctt attttccttt 130980 atgttaaata atcaccctct ctgacattgt agctttttaa ggaacacatc atgtagaatt 131040 gataggttct tttggtagaa ttcccaactg tgatatttat ttcatgacta cacatcattc 131100 tcagcaggtc aaaaatcatt gtattatgaa catctaaatt ggttctttaa tatatttttg 131160 ttagcagcag cacatctcct gaaaagcaac actgaagtcg attctgcgga cataaggatg 131220 atttggcatt gacatctgtc agcctgttaa ttactaagga agatttggct gaattaattt 131280 gtttcctggt tagctccttt tctctgctcc attatgccct ttactatgtt gcaaacttga 131340 acaaattaaa gatacattcc aagatatgag aagaattttc atcaaatgta tgaaaatcaa 131400 gtacatgaga aattcagttt ccaaaatata gggcatcatt gtgcagacga acagcttttt 131460 gaacctttct gttgaggaac acttccagtt ctataacatt tcttcagaca tttaatgaca 131520 gtttcctctg tgccaggcac tctctgtaag gtgaaagctc aggctgggaa gaggggtggg 131580 agtagggtga atgggaagcg ggtggggaca aggaaattaa cataagtgga catgcacaac 131640 aaaaaggccc tttcgggcgt taattttgta tcacctgcct gtatttctat tcaaacatga 131700 aaaatttttg aaacaaattt gaagggggag tggtccttca ccaataaggc accaataagg 131760 caggttattt tctcctttgt actggcaacc atcttttctg tagtttatgc tctgctcaca 131820 ccctatgtgc ttgtttccca tctgagataa ccctgcccct tttctgtttt catgaccatt 131880 attcaatgga aaattggaat aaagtaaaac aggacaagcc tgaattactt tgggctcttt 131940 gttatatctc atcatttttt ttggtctctt ttctccacta catttaaaac aaaaaataac 132000 ctttgcctgt gcttttccct cacttctaaa tatgtttttt ttaacctttt ctttcttctc 132060 ttttgtgctt gctttcttag ttaacattac aaattttctg ttttttctaa agctaatttt 132120 aaaaggaggc ctataatatt tgtgtaaagt ttttcattcc tccagtcatc ccattttcta 132180 tatgacttta atgtgttatc tgccagaaca actagaatag atatctccat tatttctgca 132240 cagatggcag agtgaacaag actttgtcct tagaatttcc atcaacaaaa caaaaccaaa 132300 ccacttacta tatatgtatt gccattcatg tttaagtgct gaaaatggac ttggagactt 132360 atctcagcac tatcacttat gtactctaac tcttctttat ttgagtaggg aatccttctt 132420 gtgacttcct tcagggtgtg gacacattga aagattaatt attcacatat cagctggaaa 132480 aaagtgaggt gacaagtgtt gacatttgcg tttctgaaag aggcacattg ttacatcaaa 132540 aaaaggataa tgccaattag gatttcatat gtgttgtttt attttcacaa ttacaatgtt 132600 agaggaaagc tcaaaagtaa aggcttttgt gaaaatgatc agatgataaa tcttgatacc 132660 tgtgtaagaa gtgaaagcac cagagttttt ttagaagatg aaaaatgaaa aaaaaaaaaa 132720 aaagaaaaag aaacaatttg gcattgttag aaattcttta ttgggagtgg aaaaacatga 132780 aataaaggga aaatagcttt aatcaactcc aaattccttc tttggaagtg ctgtgtgtaa 132840 tctccaataa tggtggtgta catttccccc aactctatta aaaccatcat tatcattgtc 132900 atcttcatca acatggtcat catcattgaa cacacactcc atacaaagta agatgttatg 132960 tgtttgtatt ataagcagag attagacaat aactctaatc acaaggatgc tgtaactagt 133020 agtgtagatg gtagatgtgc acaacaatga agggatgttt gatggtatct aagttgtgta 133080 atcattaggc ttacttgaag agtttcccct aatttttcta tttttctttt tccttttttt 133140 tttttttttc aaacagggtc ttagtctgta cccaagctgg agtgcagtgg cacattcctc 133200 atggctcact ggaggtgcct cagcctcctg ggctcaagca atcccccaac ctcagcctcc 133260 ctagtagcta ggactatagg catgccccac accagctcat tatttatttt tttatttttt 133320 tgcagaaaca tagtctcact ctttttccca ggctggtctc aaactccagg gctcaagcag 133380 tcctctgtcc tcaacctccc aaagtgctgg gactacaggt atgagccact gtgcctgacc 133440 agaatttttc ttgaatgtga tattctcctt cattctatta cacataattt ctctaatctt 133500 cataatttaa ttatcattga atttcagtct atctgattca tgtaaagaca acctgtcatt 133560 ccaaacatga tttgtcctct ttacaaaact aatctgatat gaactgtatt tgattcacta 133620 gagaacagag tatagtgatg cctcaagtta ttgatacctg cattgatcag ggtaactaag 133680 gcttactact ggaacaagca gtgctgtaaa tctcatgggc ttaacatgaa gtctgatatg 133740 gatttgggtg ggggctttac tagggggctt acctctaagc agtgacaaaa ctatgtaggc 133800 tttattcaat tgtgtggctc tgtcatcttt aagtccatca cttcctgcct cagctacaga 133860 agagagaaag aatgaactac caaatgagac tttttaggac tatatcacat gtggcttcaa 133920 cttaagagca acggtagctg ggaaatatca tcttcctgtg tacctcccaa aaaataaaat 133980 gggtttgtga atacatagca ttttctttat tacactatag aatatccaaa tagagatcgg 134040 atattttata gtgtaataaa gaaattggga aattaggagt tagggctgaa tgataaatat 134100 agcctttgaa gacagtgaca atgatataca gttgattagt tggatattgg ataataaaac 134160 ccatcaccta aagaaagagc atagcaaatg attaaaaaca ggatttaaag aatggttttt 134220 acaatgaggg acaatggtag aagcttattg tggtgtggac ttgtaattac ctcttaattt 134280 ccattttttt cttcctttgt aacaaaactc tagttttttg cctaactaaa agactgttgt 134340 gtacccttct ttatagtagg gtataaccac atgactaatg tcacatataa aaatggagaa 134400 cgggtgcaca ttaaagagta ggtaagtggt taatatactt tttctctctc aatcctccca 134460 acctgccctc tttaccttta tctctccaaa ataacatgtt tgttgtttaa tagagatgac 134520 atcgtcctaa tctaaggctt aagattcctg taactcttaa gtcacacttt gccaaatttt 134580 tattcaatca ctgaaggctc acattgcctc tgaaagaaaa aaaaaaagca agtgaaatat 134640 ttctgactgt gagtgttctt atattggcat cttagtgtga acttagggga tatgttagcg 134700 ttgactgttt tctgtatcac ctcaggtgta ttttgtcttt cccctcttga cttcacttac 134760 ccactcactc tgactaatgt cctagcagtg gcaagcatgt agatgtctaa aaatgtagaa 134820 attgtaagaa agaggctgtt tcagggcagc atttggaagt ggctattgtg tagggctaac 134880 catatctctc tcctgccaga ggtcatggcc ttgttgatgg tctctagtca agagcaatcc 134940 cattagtgaa aaaaaaaaaa aaaaagaaaa ccagcactga cagtgactgc ttccaaatat 135000 tctcctgtct gctactatag aatttcctag tgtttcccat cttgtcaatt cctttccctc 135060 acctttttta cactgagtga acaactttta tttgaagtgt taggtactaa cccagttctc 135120 tcacccttta ctctgcttcc ttcctttctt aaatgcttcc tgctttgtaa ccctctgcag 135180 ctagtgatac attagtttat gtttgtgttt tctcaagaag tgaaactgtt gtaggttgac 135240 ctattatata gaagtacata ctcctcagta gaaggcaact tatgattgta gaaactgggt 135300 gtttcgtgag aagttgctac ttaactgacc aattaggaaa aggggtacag aaatgattga 135360 gacctccaag gagatacaga ttcatttaag ttgagtgtac tgctgcagac atcattttga 135420 atatctgtat tacgagtaaa tggtggaaat ttgaagacaa gtccatactt tatgaaagta 135480 agagaacaag aaatttgttt ccctaaatct gtgagcatac cctataattc atcagaaaca 135540 gcaaattcac aaacacaaaa ttgacagaaa tatgtaaaac ttttccagca gtttacttct 135600 gaatacatta gaaaatgtga cagaacatag taaatttctt gtcattttac ttcccaaggg 135660 aagtgctagg tttgtaaatc ctagaatatc atcaaattat attttgaaat ttatttcttt 135720 ttgagctaga attttaaaag attacatgtt ttttcacaga atacgttcat ccagttacta 135780 ataatgatgc tgaaggaatg gaaatgtaat ttctagaaat catcactttt caaagtttta 135840 tagtttgtga actggaatac tgaagatgga agtatgattt aatatttggt agaaacagga 135900 gagtttgtta tttgtagctc tgatattaga aattacttga ggtttctgtt accaaacttc 135960 acaaaatata tttcataaaa agcattctta actcaggtta tacatttttt aaaaattatt 136020 ctgaaaggaa ttagatattt aacattgtag ctgacctaaa taaattggag aaaattctta 136080 aacaattatc tttcattttc ccatcaataa atggagcaat aataatacct aattatttat 136140 tgcacaggag tcttgcaata attaattaaa gctttaaagt actttgaaga tgaaaacaat 136200 tttataggcc tcattattaa aggtaatttg ttatggtaac cagtcaaagt cattcatttg 136260 gtcttttaaa cttgttttta aatgctctat tcggatccag gtgttaatta aaaaatttta 136320 aaacaacact taggaaacat atgaaattct gctttctatc ttgatgctta acttgtgaaa 136380 taataggtaa gttttttttc cgaattttgt ttttttcatg tttatacgcc tctctcaaat 136440 cccattgagt gagcgagtat tgctcccagc tcattattac aaaaagaggt ttgccatgtt 136500 aaagccacta agatttttct ttttctgaag ctctttactt aatgcaaaga caaagtgtca 136560 tctatgataa caattctgca tatggaaaac acaaggttat tcatccattt aaacatttat 136620 tgagcaaatg ctatagttta aaaaagataa gccactcggt aaattggaaa atatagtaat 136680 atgtcacttg catgaaattt ttatccaatg aaataatcaa gtaattaaat ttaaggtgaa 136740 agtgattgat gtaatatagg ttaaaagcca gtatggcaaa ggctgaaaca ttacaaagag 136800 aggcatcaaa tgtggttttg ggaagcactc aatttttgtg tagataatat cctagatgta 136860 cctgtatttc ataggaaaga aggcagtagt ggtattctag aacagtggtt ctcaacaagg 136920 gcaatagtcc cctgtccccc attcctggga catttatcaa tttctggaaa tatttttggt 136980 tgtcacaact agggaagtgc tacttgcatc tagtgggaag ctactaaaca tcctacaaaa 137040 cacaggacgg cccaccacaa cagagaatta tccagcccta aatatcaaca aaactgagct 137100 tgaggaagtc tgctcttgtt ggaaaacaca gaactatcaa ggcaccagat ggagaaagta 137160 taagatgtat atcaggaata gcttggcagg agtagacgtt gaaggtaaca ttgaaaatgc 137220 tttaggatag ccttgattat tagattagac tacaaagctg actcattgaa tcactcacgc 137280 actgtgagtc attcaataaa catttatatc tcaggcaata cggacagaga gatagaagat 137340 atagatgctg ctgtaaagtt tacaatttag ttggagacag tcagataaac cacccactgt 137400 gtgaacaaag tgatatctgt caaacaccaa ttctactgtg tctttaaaaa aagttcaatt 137460 aaaaataaat tttggaaaga gtatgcacta catacttctc cacaacttgg gactatatac 137520 aatcttgttt tgtgtatcag tttgccttta tttcagccag catttctttt ggcagtgtac 137580 ttttaattcc cttttatata acaactatta gcaacccatg acgtattgga tagcttccct 137640 tccagactca ctctggaccc ttctctgtgc tattccaggc tcaagatact gatcttcggg 137700 aacttcatgc tgagtgtccc tgtgttcggt tcttgattgt gtttggccca agagggacat 137760 ttataggaga tgagagggtg agaggagaca ggggttgggg catttggtcc ctcaactccc 137820 tcctccaaat agccaggtca ccacagactt gctgcatccc tccactgaag gccacactcc 137880 tttcagatgc cctttcttat agagctaccc tgtctgggtc cttataactg tttcctctcc 137940 ttatcccttc tatctaaagc tggcaatgtt cctcatctgt tgtgagctgt atgctgcttc 138000 actatccctc tttaggaaac tgcctacaca tttgtaaaaa tcctttatta agcactcctc 138060 aaagtgccag tctaggattc tcattgttat atatggggaa catgacttgg gaactgcttg 138120 tatggtagtt gcttttaaaa agagttctgc ataggaagga gtccgaaaag tttaaatttc 138180 atattatgac ttatgcacat ctattgaaga atgtatctgt tagcttattt attcctgcat 138240 gtatgtatgt atctgtatgt atgtatttat ttattttgag atggagtcta gctgtcgccc 138300 aggctggagt gcagtggtgt gatctcagct cagtgcaacc tccacctccc ggcttcaagc 138360 aattctcctg cctcagcctc ccgagtagct gggattatag gaacctgcca ccacacccag 138420 ctaatttgtg tgtggtgtgt gtatttagta gagacagggt ttcgtcatgt tgtccaggct 138480 ggtctcgaac tcctgacttc aagtgatcca cctgcctcgg cctcccaaag tgctgggatt 138540 acaggagtga gccaccatgc tcagcctctt ttatttattt ttaaatgtgg tttagctgtt 138600 ccgcaggacc attctgatgt tctccatata attccatttt tgctatattt ggtttcagtg 138660 aaaatgtaag gttttgaaaa agtgaagtgg ctcaagagtc atgctttatt ctggtagatg 138720 gatttcaaag acgggaagaa ggcatgaggc aaggagacaa acccagatgt acatttaata 138780 atgagtaatt aatactttat tgattatgtt ttcctttatt ttataattct aatgaactga 138840 cgccaatatt tttaaaaagc aagataatga tttgaagaga gttagccatg gcagggaaag 138900 catgaatgga aaagagattg tgctgttata gtgacagtgc ctggaaactc attgaacctg 138960 acagtgtaga aagatgatgt gagataggca gggaaagaca gtagtaaaaa tccaaaattt 139020 aacgtacgga aacaaccatg tctgtggcca ttccactctg aacacgccga tactgtctga 139080 tctcagaggc taagcaccgt ccagcttggt tagtatttgg atgggaagaa acatcttctt 139140 ccccaattcc tttttagtta ccaattatat ctattacttt tatgaatgtt aagagtctac 139200 attgagatta gattagcatg caggggtatg acaatctttt aatggagaag gtaacttctg 139260 gtatctataa actggagaaa aagtgattct tcttacaaga aataaactgc agatgcaggc 139320 actaatagac tgaagcaata actctatttc cctcttttga tctttgaagt atctatatca 139380 aaaaaatctt cttggtggtg gggatatact acatggagat gggccaaaga ctacaaagag 139440 agacttaggt aaaatcttgt ctttgtatga ggattctact tgaattcaat aggcctgtgt 139500 ccctaaagaa aaaaaaatgt atttattgca aaccaattta gcttaagtaa aggtacacat 139560 tttggggttt tattggttgt ggttgttcag ttaaattata cttactgtac tggacaccat 139620 atacgccaat cactgttatc aattctagga atgcacaaat gaataaaata tggtccctgt 139680 cttttctatt ttctgtgaac tttctactta cgtcacaatg gtgcaatggg aaaagaagaa 139740 atggatcatt tattcaaccc ttgataaaag aaagacccct cctagttagc atggtggtag 139800 cagggataat ctgtaaggaa acctaaatcc aatgtgaacc tctgaagaaa gtgaggatgg 139860 ttagagtaat ctagtcttgc ctccacatca ggacatactt gccatgacca gcctgggagt 139920 gtctattttt tttccccatt aaagagggta gcatttcctt ttagttaata ctgagattcc 139980 cccctagaaa ggttctaata attgtagtgt aacaaagtta gtatcaggtt aatatccact 140040 ttaatgggag aatttccaaa actaatatta tcagttttaa tgataccttt ttgatttacg 140100 aaatgtctgt tattcacata gtttttgtta gcagtcaaaa ccaacaaaaa tatttgatga 140160 acccagataa atatttgaga aacttgtatg ctataacact tcattttaaa agatatgtat 140220 tttgtcatct ccaagttttc tttttaaaat tgttattcca acccttcttc ccctcaattt 140280 accagcatca ctaaatgccc accttatttc ccagtagttt atgtgttctc tcatatttta 140340 aaaaggtttc ttgaggtata atttacatat tataaaatta tttatttatt tatttaattc 140400 atttttaaat gtggtttagc tgttccgcag gaccattctg atgttctcta tgtaattcca 140460 tttttgctat atttggtttc agtgaaaatt taaggttttg aaaaagtgaa gtggctcata 140520 aagagtcatg ctttattctg gtagtgtatt caggtgtaca cccattttaa gtgtacagtt 140580 caatgaaatt tagtaaattt ttataattgt gcaaccatca ccacaatcca gttatataac 140640 atttcagtta ccaagaagtt tccctcatgc ccctttgcag ttaattcttg ctcccgctgc 140700 agccctaaca acagccacta atttttctgt ctctataatt ttgccttttc tagaaatttt 140760 gtataaaagg aaccatacaa tatgtagtct tttgtgtcta attatatttg tatgtttttg 140820 aactattaac ttgccacatg tattagtact ttgttccttt tattgatgag tagcattcca 140880 catttggata tattttgttt attcagtcat cagttgatag atgtttggat tatttctagc 140940 atttgcctat tatgaattgt tctgaacaag cgattatgaa taatgatttc tcacacacaa 141000 gtgttatgta aacatatgtt tttatttctc ttgggtagat acctaggact aaaatttctg 141060 ggttatatga taagtatatt cttaactttt aaagaaacta ccaagctacc acttttccaa 141120 tgtgtacgta tcattgtgca ttgccaccag caatgtaaaa tggtttttct acactcttac 141180 caacacttga tattgttagt tgttttgatt ataatcactc tagttggtgt gttgtggtat 141240 catcttgttc aatatccatt ttcccaatgg ttacttatgt tgaacatatt tttatacgct 141300 tttgcatatc tttttcaatg aaatatccac atcttttgct catttttata ttgggttatt 141360 gtcctcttgg attgtaaaag ttcttttttt attccaaata caagcccttt cctagatatg 141420 attggcatat attttttccc agcctgaggc ttgtctttgc tttatcttaa tggtgtcctt 141480 aaaagccatg cttgtgtaaa catatgtatc cacaaacata aacactgtag gagttttatt 141540 ttgttttttt atcttattaa aatggaactg actctatata cttttcagca tcttgatttt 141600 ctcattcaac attacctcat agaaattcac ccattagttt caatttatta tttttaatga 141660 ctgcatacta tttcatggta tgcattcccc cactgatgag cattcaattt gtttctaggt 141720 ttattccaca cccccaacag ccagtaaaac aataaccaca tttgtaccca tttatagatc 141780 cttaagtacg ggtgcttttt atttctgtag tttcaagtcc aggagtaaaa tttttggctc 141840 aaaggcttat atggttttat tttgatttat gttgccagat ggctttctga aacgtatgtg 141900 ataattcact tttctcccaa atgtgtgggc atcctttctc ccatatccac ttaagtcagg 141960 gagctgtcca ttttcaaagg ttgttcagtt aaattgttca gttaaatgtg actgggcatt 142020 tgcattccta tcatgactag caaatttggg cattttcacg tgtttgctag ttgactgaat 142080 ttgctcaatt gttaacttca gtttaaccct ttataaattt ttcctttggg tgttttgtct 142140 ttttttttta gaatataaat atatttggaa ttgtagatat tgggttttgt catttgaatt 142200 gcaaatattt cttccagttg tattgtttga ctattggttt tgcttttgat ctcccttgct 142260 acaagaattt ttaaatttta ttattcctag tcttgaaata tttgtaatat cattactata 142320 tattttctaa ttctttaagg tgggtactag attcctttat ttttgtcttt ctcctttaat 142380 aaaggagtag tgtcctggaa gtgataacat cccagtatca aacacctaga gtccagatct 142440 tggtttctga aggtcattta cttctaaaaa gaaccaagag tgcttggaga aatggctgat 142500 tacaggttgt ggccaagaaa aaacaatcag atctgaatta ttttgtggcg ttagaaacaa 142560 ggaagtactc agagactaat ggagggagtc atgttaaaag gactcagaaa tcacattcaa 142620 ggagccactg ctggtctact ctggaaaaaa tttgaatacc aaaaatagag aataaataac 142680 aatgatggta aaggatcaca aaacatttga ataaacaaaa aaaaatcttg agtcagcaga 142740 gatattccaa aaaaatgaga gactaataaa tgtagggaaa acatgtatat ttaagaatca 142800 ctattgcagc tccagtataa catttgatta ggcaagaaca tggacagagg ctaaaatttt 142860 ggccattaga ttgttgggga acacggtagt ctcacaagga tacaatgttt gataaggttt 142920 ggctgtgtgc ccacccaaat ctcatcttga attgtaattc caaatgttgt gggagggact 142980 ggatgggggt aattgaatca tgggggcggt ttctcctatg ctgttcttgt gatagtgagt 143040 gagttcttat gagatctgat ggttttataa atatcttgca tttctcctgc tatcatttat 143100 tctctctcct gctgccctgt gaagaggtgc cttccaccat gactgtaagt ttcctgaggc 143160 ctctccagcc atgtggaact gtgagtcaat taaacctcta ttattgataa atcatccagt 143220 ctcaggtatt tcatcatagc agcatgagaa cagactaatg cagtaaattg gcaccacaga 143280 gagtgatgtg ctgctataag ggtactcgaa aatgtggaag tggctttgga actgagtagc 143340 aggcagaggt tgaaacagtt gggaggactc agaaaaagaa aggaaaatat gggaaagttt 143400 ggaacttcct ggagacttgg agggctcaga agacaggaat atgtgggaaa atttggaact 143460 tcctagagac ttgttgaatg gctttgacca aaatgctgat agtgatatgg acaatgaaga 143520 ccaggctgaa gtggtctcag atggagatga ggaacttatt gggaattgga gtaaaggtca 143580 ctcttgctat gctttagcaa agagactggc gacattttgc cctagaaatc tgtggaacat 143640 tgaacttgag agatggttta gggtatctga cagaaggaat ttctaagcag caaaccattc 143700 aagaagaagc agagcttaaa tgtttggaaa atttgcagac ttatgatgca atagaaaaga 143760 aaaacccatt ttctgggaat tcaagcctgc tgcagaaatt ttcataaata acaaggagcc 143820 aaatgttaat caccaagaca atgaggaaaa tgtcagagac cttcacagca gcccctcgct 143880 tcacagaccc agaggcctag gagagaaaaa gtgttttgtg ggccaggccc aagcgccccc 143940 cagccctgcc ccccggcagc cttgggacat ggtgcccagt atcccagctg cgtcagctcc 144000 agccttggtt aaaaggagcc aaggtacagc ttgggccatt tcttcagggg tactagcccc 144060 gtgacttggc agcttacatg tggtgttggg cctacgggtg cacagaagtc aagaattgag 144120 gtttaggaac ctccacctag atttcagagg atgtacagaa acccctggat gtgcaggcag 144180 aagtgtgctg cagcggtaga gccctcatgg agaacctctg ttggacaata cgaaagggaa 144240 atgtggggtt ggagcctcca cacagagtcc ccagtggggc actgcctagt ggagctatga 144300 gaattgggac acaattctcc agaccctaga atggtagatc tactggcagc ttgcaccatg 144360 tgcctggaaa agtcacagac actcaatgcc agcctgtgaa agcagccagg agggggcggt 144420 accctgcaaa gccacagggg cagagctgcc taaggctgtg ggaactcatc tcttgcatca 144480 gcgtgacctg gatatgagac atggagtcaa aggaaatcat tttggaactt taaggtttaa 144540 tgactgtcct attggatttg acttgcatgg ggcctctagc tctttggctt tggccaattt 144600 ctcatttgga atggatgtat ttacccaatg gctctacccc attgcatcta ggaagtaact 144660 aactttcttt ttattttgca ggctcatagg tggaagggat ttgccttgtc tcagatgaga 144720 ctttgaactt ggacttttgg gttaatgcta gaatgagtta aaactttggg gaacctttag 144780 gaaggcatgg ttgtgtttta aaacatgagg acatgtgatt tgggaggggc cagaagtgga 144840 atgatatggt ttgggtgtgt cctcacccaa atctaatctt gaattgtaat cccacgtgtc 144900 atgggaggga cccagtggga ggtaattgaa tcatgggggt ggtttcctcc atgctgttct 144960 tgtaagagtg agttctcatg agatctaatg gttttatgtg tctggcattt cccttgctgg 145020 cattctctct ctcctgccac cctgtgaaga ggtgccttcc tccatgattg taagtttcct 145080 gaggcctctc cagccataca gaagtacgag tcaattaaac catttttctt tataaattac 145140 gcagtttcag gtatttcttc atagcagtgt gagaacagac taatacagtg ttacttcata 145200 aattgcttac taatcgaaaa ggggaaaatg tattaatacc tttaagatag aaagatctgg 145260 caagtagaca aacttaacgt tgcaagtaat agaacataat attttgtttc tcctctgcta 145320 tgcagtataa agtacctaaa tcattaccaa caaactatgc ttaccaaaaa tgtttattct 145380 aaataaagca tctactgtgg ttctcattta tatagtaagt ataggaatta gagaaacaaa 145440 tgaagtagca ccattatgca tcaatcagac aaatccatga tttgggacat tctctaagtc 145500 aactaatttg gctcttttag aaagtgaaag tcaagagaaa ataaaaatgt aggaggcatg 145560 gcatggtggc tcacacctgt aatcccagca cttagggagg cagaggtggg tggatcactt 145620 aaggccggga gtttcagatc aacctgggca acatagtgag aactcgttct cttaaacaac 145680 aacaacaata aactcttgcc agcagaggtg tgctattaaa aaaaaaaaag taagagaact 145740 atcttgatta aaaatgattt cagagaaata atctttattg caatatgaga atttttcttt 145800 gaatactgaa gttgttttta aagatataaa atttattttg atgaaaattg aggaaacttt 145860 aatatggact gaattagatg acatgaaatt attattaatt tttaacaatt gtgataatgg 145920 tattgtactt atgtagaagc atgcccttat taggatatgt gtgctgaatg taggctttaa 145980 ttgctgcaaa agtcttcctc atgtaaagtc aaaatttttt aggtactaac tattggtctt 146040 cgttccgcca actggagtta aaagcatcag ttgatactgt cacaagaaaa ttatcttctt 146100 tgtattagta aaataattaa aattaaaatg tatatataca aggcagagaa ttacaaaatt 146160 tgggtatcaa tactactata ttaattttat gctactatag tatatgccct tttagatgtt 146220 taatatctgc taacagatat gtttaggtag aaatgatgta tatcaggtat ttctcaccat 146280 ttagatgcca tgaagttgct gtgaattaaa taaacatttg tttggtaaac tgcagtaacc 146340 tattttaaag tgttctttaa aaggtatgta taggccaggc gtgatggctc acacctataa 146400 tcccagcact ttgggaggct gaggtgggca gatgacgagg tcaggagatt gagaccatcc 146460 tggctaacac agtgaaactg cgtctctatt aaaaatacaa aaaattagct gggcgtggtg 146520 gtgggtgcct gtagtcctag ctactcggga ggctgaggca ggagaatggt gtgaacccag 146580 caggcggagc ttgcagtgag ctgagaccgc accactgccc tccagcctgg gcgacagaac 146640 aagactccgt cttaaaaaaa aaaggtatgt atatatacat acatgcacag acacatatat 146700 atttgtgtat cttttttaag attatatcta ttttatatga tgattatata ttatgtgata 146760 tattattata caataatata ttctataaaa ctattttttc ttcaatttat taaaatatta 146820 ttttcatgta atcctggcac tttggcaagc tgaggtggaa ggattgcttc agctcaggag 146880 tttgagacca gcctaggaaa cataaaaccc aactcataaa aattaaaaat atgtatactt 146940 ttcggtttta tacttgacag gctttacaag aatttcaagg agatataaaa ataatgcaaa 147000 ttgtctggaa gaactcgcct ctcctctcct tactccaccc tgctattggg aaaaagatta 147060 actgatggtg agtggtgagt ctataatacc atcactccat gttcctggat gttaaaagtc 147120 actcacacat gtgacttctg tctttacaac acatgaagta ggtaaggcca gaattctgct 147180 tccagctaac tgggagaggt agtctgttcc caaagactta aaatatcctc aggtcaggag 147240 tttcaaagtc tacacttaga gggaagaacc aggaagtccg taaagtcata ggtttcaacc 147300 gcatccttca atttagtatt tctaacaaca atgctggtat tttgatatcc atctctttaa 147360 tacctgcttc tatttccaac ttgtttagaa cttgaagagg gagataaggt ttaattttgt 147420 gccttcccca agcccagcat ttagggatgc agagatatta tgtattttaa gcatgtgctg 147480 tagtagccaa tgggaatcca gaatgttgtt gtttatttgc attttaattt actacagaat 147540 tgttgatttt aggccctttg atccaatgct aatttaaatc attttcaata gaacattgtt 147600 tatttccctt catgctttat aactctaaat aataaaaaat accatctttc actttaaagt 147660 ccatattctc caggcattat ttttgagctt cacataggct tagaagaaaa actgatcaac 147720 agtagtgatg tggtggttgt ggaagcagtt gcatagctta gatagctcag gttttaaatc 147780 tcacctttgc cttatgttaa ctgtgtgaac aggttaaaat tactttgatc tctctacacc 147840 tgtttccttg tatgtaaaat gagagtaaca aaagagtagc tgggaagatt agtgagctaa 147900 gacatgcaca gtgattacca tgtctcctgc catatacgcc tcaaaaattt agctcttatt 147960 atacttgttt ggttcatagt aggtgaagtg tttggtagaa aaattgggaa ttcattcctt 148020 tcttgattag agtgaatgac aatccatttg cagaaagctg cagaaagacc gctccagaaa 148080 tagaatgagg caaccgctct ggagaattga aaactaacgg gagctacgct ccacaaaaga 148140 taaggaaata aaaatgccag gaacaatatt ctgagaagaa gggaaaacaa aagaacagaa 148200 aaattatcag ttatatagcg gggaaaaatc tgaaaggaaa aaatctcaag agaaggggac 148260 taaagaagta taaagctgat tattctatat tgatcgaccc atcaatgtgc taatcaagca 148320 gtaagcagaa ggttgcagga tggaagtatg gattcttcct gaccattcgt tacgcagtag 148380 atgctttctc tacttaatga caacagcaat aggcaactgg aaaatgtcac ttagccagca 148440 tgtccaaatc catcttcctt gactttcctg gtgaaaccac atattttatt ctagatatca 148500 ggttgaccat agaggtaaga catgcagtgc tttggagttt gtattttctt tttttttccc 148560 tttctttttt tattttttat tttttttatt ttttgagact gagtcttgct ctgtcgccca 148620 ggctggagtg cagtggcacg atctcggctc actgcaagct ccgcctgctg ggttcacgcc 148680 attctcctgc ctcagcctcc cgggtagctg ggactacagg cgcccgccac cacgcccggc 148740 taattttttg tatatttagt agagacgggg tttcaccgtg ttagccagga tggtcttgat 148800 ctcctgacct catgatccgc ccaccttggc ttcccaaagt gctgggatta caggcgtgag 148860 ccaccgcgcc cggcctggag tttgtatttt cttaattctt ttggttggta ctttgcagat 148920 ttggggagca acaattggtg agaaaaacaa tagtattaac atatgtgaaa attcagctgc 148980 tacctttttt atgtaaaaat aattcagctt ttcaattata tgctttcagg tataatctgt 149040 tgtttctata gcatcattag tggcagtatt taaaagtctc taagcctgac agttcacttc 149100 gacagatgca aagaacaata agcactgatt ttcaataagc taataagaag tagtttaaga 149160 aataaattgg cttaatttga gtttacaata atctaaaatt ttgcaaagat ttatttattt 149220 acatatcaca gtgtgctttt gaattagatg tttcttagac taatatgctt attttcagag 149280 gattacaagg atgcagtaga cagcattcca tttgatgtac atagctgcga atacatttaa 149340 cattgaaagt ttcaagcact ttcttttaga atttggattt ttcatttcag tctttctagc 149400 aagataactt agagatatgt atgagatata aagtaaatga caaaatagaa tgctatatgg 149460 aggaaaattt gatgaaaata taattgattg agagattttt gttgaacaaa tgaaaccaac 149520 gattttttcc ccatcagaaa ctaattgcat ttctttctta tttccttgga gacacatgtg 149580 gaataaaatg taataaatac tgtacttgtg tgtttactta ccagaatgtt ctcttcagaa 149640 aaagtaatga taccctttca ttgacatcat ccaagtgata atatactttt gtttctgtca 149700 ttggagtaat aataaccttt caaccacatc actgcacagt gcttctttct tttattgtac 149760 ataatgcata aaaataaaga gggtatatta tttcttaagg aaataggttg ttatttaaat 149820 aaattccaag catcagaaaa ctacagttct tgctgatgtg tactaaaatt tctatagata 149880 cttataactt tgtatagaaa tttaatttta atattctttc aattgtcaca tcatacttaa 149940 gtacggatct ccactatttc acatctcaaa aatatgactt aaaaccagtt atagttgttt 150000 ataccccgat gataagggat tagaattttt ttttgccaaa tactccttag gctaagtttc 150060 aaagtctggt ttgtataaaa tattactagc agataaatag tttgttaata aaacatccaa 150120 gcttgtgctg atgggtgaat ttgctataat gtaataaagg ctgacactac tcatagtgag 150180 aatttaacct tttcctcaga ataccttatt catttaaatg aactcacagg tttaatgtaa 150240 aatatttcat atatatttga tacgatcctg tacaaattgt ttcctagcat aataaattga 150300 atacagtgtg aaataaattg tgactttgtt ttttttactt agtatctcaa gtttgaagaa 150360 tataagttct ttatgttttt gcttaagttt gatttacttt atcattaatc ataataatag 150420 gatttgtgct ggatgatgga aatccaaacg gtgttactca gtataataag aaaagtgaac 150480 tacatatgga atgtttaaaa taaagaacta atcttaaacc aatcagattg tttcatgatg 150540 cagacaggaa tctcaggaaa taggcttagt ggaattttct ggcaattaag tataaaattt 150600 tacatgcttt aagtaaatat ttcttaaaca agtgtctatt tctggtctca ttccactctc 150660 caaagagttt catctgagct taataatgtt ggtttgaagg catacttgca aatagagggc 150720 agaaatgtta actctatttc cagatttcta ctattgcaaa cagtctctaa gttaaagcca 150780 aagttgtttt ctattttatt ggagcaaggg aagcctgatt aaagcttttt ttagaataca 150840 tattcactca gcagagcaag aaaacaacct caagactgac atagctgttc taaaagtcat 150900 cttttggttt tattgttgga aagagggatt gctcatcaaa tcactgataa taagaatgct 150960 tagatgacgc tgttatgtag ttgatgttac ttagcatgcc aagtctcttt ctgtacatat 151020 taaaagtgat acgttgttct cagccaagac taataaattt ttttctggta acagctttat 151080 tgagatataa ttcacaaacc atacaattca cccactgaaa ttgtacagtt cgatggtttt 151140 tactatattc acagttaatg caaccatcac tgcaatcaat tttaggacat tttcgtcact 151200 ccaaaaagaa atctcgtatc tattagcaat cgctccttat ttcctcctaa ccacccctca 151260 cccaacctct cagctctagg caaccactaa tttactttct gtctgtatat atttgctatt 151320 gtagacattt aatataattg aaattatata gtatgtggtc tttcgtgact agcttctttc 151380 acttgtcata gtgttttcaa agctcatcca tgttgtagta tatatcagta gtatatcaat 151440 gtgttttatt gacaagtgat attccatcat gtgtatatac cacattttat ttagctcttc 151500 atcagttaaa ggacatttgg gttgtttcca ccctttggct attatgaata atgtcgctat 151560 gaacatttgt gtacacattt ttgagtggac atatgttttc acttctcttt ggtatatgcc 151620 aaggagtgga attgctggat tatatagtaa ctctatgatt acccctctga ggaactgctg 151680 gacagttttg caaagaggtt gtgccatttt tcattcccat aagtgttata tggggattcc 151740 attttctaca tgtcatcacc aacacttgat attatctgtc ttttttttat tatggccata 151800 ctgatggggg tgaagtagta tttcattgtg gttttgcctt acgtttcctt aatgatgttg 151860 acattcatct tttagtgctt tattggctgt tcgaatatct tctaagataa atgtctattc 151920 agatcctttg cctatctaaa aaattgtgtt gtctttttat tgttataata agagatcttt 151980 aaatattctt ttatcaattt tgctttgtgt ggtttactaa ggtaaaaacc ttgggtgtgc 152040 aattaataca ttcaattgtt agcaaaatta ttaaaacaat aacttataat ttttggtcca 152100 cctgaaatag ggaaactaat ttgactcaac ttttctttca attgttgtgg agtctggttg 152160 actgccaaat tttgtaaatt ttaatatttt acccagtaaa aagcttatta aataatagga 152220 tatactgatt agaggttact ttcaagaaat taaatatttt tgtgtcttca gaaagagttc 152280 tccttttgga aagatactat atggataaag aagtaaattt taagtacata tttttttaaa 152340 gtgcatcagt tattatttaa aggaacattt aaattttagc atttgagcag ctatctttcc 152400 tccttcaaag ttttctcatt atcctttcct tgtacgtatt attatttata ggctgcaaat 152460 gaaacctaaa agaacataaa tggttttcta tttcaacaaa agcaatcacc tccacgtctc 152520 actttcttat ctttaattaa ataagtaaga taaaaagtaa aaatcatggt tgcccctttg 152580 gttttgctgg tctgacccat tatcccagca cattgtggta gagatataat aagcctgctt 152640 tgcctagaag atcacttagg aacaaccaag gcttggggaa gaaatcagtt gccactaaaa 152700 tgtcaaagta tcaagtattt ctgcatgtgt aactagagga aaaggagaga agacagcagt 152760 gcttctgatg aggcccaaga tctctggcat ttgaaagaaa ggtgaaagct gttgatggtc 152820 actttctttg ggtctctttc cttgggtcag gattgtacat gaaagtcgct ttagatacat 152880 tggccagaaa gaatgtgtgt agcctaacac aaacgtgacc tactttttac gaaaggaaga 152940 aattcttggg aggtataact gaaaattatc gtcccaattt acaaactcac tggacagtat 153000 gaatttctct tagggctcct aatctatttc agtcagacag taagtcttcg ccatgaaaac 153060 aaaacgaaat ggactataaa actgaacagg ctgggcttag ttatagatct gattgtttgg 153120 ctatgtgcag ggaaccagca tttaaaaaat aattccagct ttaatctgaa ataaagcaaa 153180 gtctgaatgt atggcatagc ttagtgaaaa aataagctca taaatgtcta taaatgcatt 153240 tataaatata tttaaaaatt tttaaagcag atgcaattct ttgtcacaaa tacggatgtg 153300 attctaaata tcagcaagtt tctgctaaca aaaagatgca aatgaaagtc atgatccaaa 153360 acctgggcat agtaataatt ctggtatctg gtttgagttt tagctccttt cttagctgtc 153420 agcaaaatca tcctctgaac ttctcactct tatgcctgcc cgtctttatt ttaactcata 153480 gacaagcagt tggaattttg ccatttaaca gccaagccct gtggcaggat aataagtaac 153540 agtccactaa catgaatgca gagaaaagca tatgttaggc caggagggat gaaaattgtc 153600 cacatagaag aaaaaataga aaaagcaaga cagaaagaaa aagataaata aaaccttaag 153660 ggcaagaatt ttctgtttac aaatatgctc tcctttagcc tagcttttac aagtgggtga 153720 ctgcattttg cagtcttagt aaatcacgac tgcttaacca tgcatttaaa gctattaaat 153780 taagttacca acagccaatc ccccaaaact tatatgcatg aaaagacata aaaataaaat 153840 aaaacaataa agaaaatttc ttatttaaaa tttaatgttg atatgattaa aaacatatat 153900 caacatctta aaagcaatca gacttcataa tcaaggagta ggcatgttat aataaaaaca 153960 agctctagtt tcatttctgg tgcaggttta atttattatt atttttttaa aagctgaaaa 154020 tggtaggagg tgattcattt gtttggattg aggactacat ctggttcaga gttaatagtc 154080 atctaaaagt aaagtatcat ttgagaaggc ttaggggtat gccggaagtt ttaactttta 154140 catcatttgc taatgtgcta gttatctgga agctattaaa ttagaatatc tgattttgct 154200 gagattaaaa agaaatatta gacccatagt taattttttg tgcagaacgc ttccattata 154260 ttctgccaag ttttaaacat ccaatgtaac agcctgtttt tgtttttttt gctttaggaa 154320 atgttcttca atttgccata taggaaatta aaaagtataa catttgaagt aggataatgt 154380 tctgagctta tgttttacaa agctttgaac attaaaactg ttcatggttt aaataatttc 154440 atggttaata tttgtgatgt ataaattcac tggtttcctc tactatggca tgttaaattc 154500 caggtaacct atatctgaag aagaattagt tgtaacaaag attttttttt taatctttct 154560 cgaatgggaa gatccatata gtataggaaa ttgtgagaat actaatgaat tactcagaaa 154620 taaactaaaa ttgtgaaaaa agtaaagaag ttagagatga gagaatgtca tgaccaacga 154680 tggatttaga cttaattgcg tatttggcac attgaagtct aagtccattg ttggtcattt 154740 ataaattttt agactgcagt ttttaatatt tggttttctc ttcattttcc tttcctaaaa 154800 ttatttcctc ttcttccttt tcatctcttc ttttattcct tgtttcccag tgaaattatt 154860 ttctagcaca gcaagacatg gttccactct gaggcgaatt ttaagatgcc gatgttattc 154920 tatttggttt tgcaagctca gggcacacat atacgagtgt gtggagtgtg tgtacgtatc 154980 aaagaagttt ttattctaag aaaattttga atataagttt gaatttatta cttttctctt 155040 ttgcctagta tgttatacaa attctacata gttttagagc caaattacag caatcagttc 155100 acaatccctg tgatcatatt attttcttaa aatttcttgt ttatttgaaa tgactatatt 155160 gacttatttt agctgaaata tagtcacaaa cagatcctct tgtaatgctt ttctcaagat 155220 tccagctgag aaactgcaaa tatgaaaata ccacaactga tttcttcaac tacttattaa 155280 atatcatctt aagttacagt tcaagatcaa cttctttggg acaagcaact atttacttat 155340 gtatgagatt tttaaaaata tcgcttatga ttgttttggt gtatgaagga tcctgtcacc 155400 caggtagtaa gcatagtatc caaccaaagc tcaggaacat gcagtttacc catgtaacaa 155460 acctgcacat gtaccccctg aactccaaag tcgaaaaata aaattaagtc ttccaatagc 155520 ttgttcttta aaaaaaagat tgtttttaaa ttttggaaat aattttctat tgcaacagta 155580 ttaaaagaat gggacttggt ccaagaataa ctcccaaact ggttgtttat ctcataataa 155640 agctgaattg tggaaatcta gaacctaact tcaatacatt gttttccgag aaaaaaaatg 155700 gaacactctt aatttatttc tgatttatca gaattttgct ctccatgtgc aatccaattc 155760 ttacctctgg atgcatgacc tcatagggga aaaaaattgt tcatttctgg ctcgccacaa 155820 tttcatgctc attttaactg agcccttacc agtgcccttc tattttaatt tatctgttgt 155880 tggttctcta acaaaatatc caaaggagta gctgccatga atattttatc tttccaattc 155940 catattccct tccttctcaa cttccatttg tattcctcat caaatgatta ttctccctgt 156000 tgatgtgaaa agatttagga cactttccct cctcctcagc ttgtcaactt gtgatttcct 156060 ttgatttcag agaaagagat gattcttcta taaaaccaac ctatctctct gtccttgacc 156120 cagcttctcc tgtttcataa gagatattac tcttatagat cttcttttct agtctttaca 156180 tacacatttg ttccctcatc cccctctggc tactgtcctc tttcctcttt tcctttagtg 156240 aaaaatgtct tccatgtccc ttgcatctgt atcaccctgg atgtaagttc atttaattgt 156300 tttctctttt tccctttcta cggagattgc cttctcaaaa tcaacttcgt gtcagctcta 156360 gcagtcacat attcactctc agtctggtta attctttagt gcatttcaca acttaaaact 156420 gtttttttct tgacttctgg gaaagcacat tatattgccc cataatactc agattcttct 156480 cttactacca cctaaatgct cagtcttttt catatattcc ttttcactcc tctgtgtgtt 156540 atctctacta aatatgaaat ctcagcgatc tcatctaccc cattactgca actctccctt 156600 ctatgtgaaa aagcccaaaa taataatcat ttcccatttt caaagagctt ttccttggat 156660 acttatattt aatctttaat aagaatttat gaggtagata cattcattac acagactacc 156720 aaattcacat tttcagtttc ctactatttg gtcattctcc ataagtcaac tagatattta 156780 ctgcacttag gcattcactg tggtgtagta atgtatcaaa aattaagtct attgtctttt 156840 tatgtcccat ccagtgtccc ttctcaacct tcctgttggt attaaattgg ccaggctact 156900 ggccaagtct gttagttcaa agtcttaaga gtaagcttca tttcaaacag tagaggcttc 156960 caatgggatg aacttggatt attatctgtt ggtgaccctc cccactgtca actcatcctt 157020 tagaagccca ctcaaatgcc agctccttca agagtcatca ccttatcgca atgctcctag 157080 gaacattttc acaactctgt tcctgtggca ctttttgtct ccatcctgat attgctaaat 157140 agtgtggctc tcagacctcg gggtgttggg tcagacaggc tcgtgctcca gtttttgtgc 157200 tgccacttac gaggtggatg acttgttgca agtcaccttt ttaaagcttc gtttttccat 157260 attggtacac agtgttcatg atcataatgc ctagtttgtg ggatgtttaa aaagattaca 157320 tcagataatc atacgcggaa ctggaacata ctaaatgctc aaaaaattgt tagctaactc 157380 actttctata atgtaatatt ctgaacacat gcagaacctg acttttaaga tccagttcct 157440 agttttgtgc ctgaggcttt acaatgctgt gatgctgtga tctggtcatg acttagaata 157500 ctttgattat ctctgctata caatggaatg tattataatt taaataagta tttgtggggc 157560 tggatgctat ggctcatgcc tgtaatccca gcattttggg aggctgaggc ggatggatca 157620 cttgagatca ggaattcgag accagcctgg ccaacatggc gaaaccctgt ctctactaaa 157680 aatacaaaat taagctgggt gttgtggcat gtgcctgtaa tcccagctac tcaggagagt 157740 gaggcaggag aatcacttga acccaggagg cagaggttgc agtgacccaa gatcgcacca 157800 ttgcattcta gcctgggtaa cagaaaggga ctccatctta aaaaaaaaaa aaaaaaaaaa 157860 aaaaaaaaag tatttgtggg atagatggaa aaatttctat aaagatgttc ataaactatt 157920 cttgctaaat tgtaaacaat gattaaaatc aagcatttga acagcagaat ctgattttgt 157980 acatctttgc attttgtata ttacatgagc aaaaccaggg tggattatat ttaaaaattt 158040 tagttatttg ttgattgaat ttactttgat gtcaatcctc catttcttat atatatgcac 158100 tttccaaatc ctattgatca aaaaaatgaa aaatctcatc ttcattaccc tgtaacccaa 158160 agccactcct ctaatcagac cccaactccc tttaagaata accataagtg tctcctactt 158220 ggccctcata cctccagctt ttaactctat taatccattt attacaatga tatacaatag 158280 ataatcttct gtaaacactc atttgaccat gcccttccct tgtttaagaa cttgcaatga 158340 cttgcttttt cctagcacag caaagctaaa tttctccctt gaattttaaa atcctccatc 158400 tgtttctact cttcctatgc aatattattt tccattattc cttaacaagc ttccaccatc 158460 ctactgagac aggtatattt tttgtctcta gtaaactagg ccctgaagat aaaaatttgc 158520 ataaaatatt cagtagcatg ttccttattt tgctctcacc ttctatgctt ttacacatgc 158580 tatttaagtc tcctggaatg ccttctccta aactccatga cccaatacac attttttctc 158640 ccctgtcaac tatttcttca tgaatctccc ccctcttaat gttgttacat agtctctaaa 158700 aataatctaa aatagatgat ttagtcatgt ggaataagat tcagaaggta tcccaggcca 158760 tgtagttaaa gtctcttaac ctcagcaaca cgcctgccag attccctcct tctctgagag 158820 atgttctcta tataaacaaa tattatatat attcttccct tatttctctt tcgcccctct 158880 ttttaataca aatgatggag ggagtatcga agctgtccct aaagaggtca caattaagca 158940 gaaacctgaa agaaatgatt gagcatatca ggtaaggatc 158980 <210> 33 <211> 405 <212> DNA <213> Human <400> 33 cttgttgcta ttttagaagg tgtccagtgt gaggtacagc tggtggagtc tgggggaggc 60 ttggtccagc cgggggggtc cctgagactc tcctgtgcag cctcgggatt cgtttttaat 120 gtgtattgga tgagttgggt ccgccaggct ccagggaagg ggctggagtg ggtggccaat 180 ataaatcaag atggaagtca gaaatggtat ctggactctg tgaagggccg attcagtatc 240 tccagagaca acgccaagga ctcactttat ctgcaaatac acagcctgag agccgaggac 300 acggctctat attactgtgc gagaggagat tactacgact atagtggtaa ttacattgat 360 gcttttgatg cctggggcca agggacaatg gtcaccgtct cttca 405 <210> 34 <211> 1749 <212> DNA <213> Human <400> 34 gatttgctct gccagcagct gtcggtgccg cgctcgacac cgagtcctag ctaggcgctc 60 acagaatacg cgctccctcc ctcccccttc tctgtccccc gcctctcgct caccccggcc 120 cactccagcg gcgactttga gggattccct ctctggcggc ctctgcagca gcacagccgg 180 cctcattcgg ggcactgcga gtatggatct ccaaggaaga ggggtcccca gcatcgacag 240 acttcgagtt ctcctgatgt tgttccatac aatggctcaa atcatggcag aacaagaagt 300 ggaaaatctc tcaggccttt ccactaaccc tgaaaaagat atatttgtgg tgcgggaaaa 360 tgggacgacg tgtctcatgg cagagtttgc agccaaattt attgtacctt atgatgtgtg 420 ggccagcaac tacgtagatc tgatcacaga acaggccgat atcgcattga cccggggagc 480 tgaggtgaag ggccgctgtg gccacagcca gtcggagctg caagtgttct gggtggatcg 540 cgcatatgca ctcaaaatgc tctttgtaaa ggaaagccac aacatgtcca agggacctga 600 ggcgacttgg aggctgagca aagtgcagtt tgtctacgac tcctcggaga aaacccactt 660 caaagacgca gtcagtgctg ggaagcacac agccaactcg caccacctct ctgccttggt 720 cacccccgct gggaagtcct atgagtgtca agctcaacaa accatttcac tggcctctag 780 tgatccgcag aagacggtca ccatgatcct gtctgcggtc cacatccaac cttttgacat 840 tatctcagat tttgtcttca gtgaagagca taaatgccca gtggatgagc gggagcaact 900 ggaagaaacc ttgcccctga ttttggggct catcttgggc ctcgtcatca tggtaacact 960 cgcgatttac cacgtccacc acaaaatgac tgccaaccag gtgcagatcc ctcgggacag 1020 atcccagtat aagcacatgg gctagaggcc gttaggcagg caccccctat tcctgctccc 1080 ccaactggat caggtagaac aacaaaagca cttttccatc ttgtacacga gatacaccaa 1140 catagctaca atcaaacagg cctgggtatc tgaggcttgc ttggcttgtg tccatgctta 1200 aacccacgga agggggagac tctttcggat ttgtagggtg aaatggcaat tattctctcc 1260 atgctgggga ggaggggagg agggtctcag acagctttcg tgctcatggt ggcttggctt 1320 tgactctcca aagagcaata aatgccactt ggagctgtat ctggccccaa agtttaggga 1380 ttgaaaacat gcttctttga ggaggaaacc cctttaggtt cagaagaata tggggtgctt 1440 tgctcccttg gacacagctg gcttatccta tacagttgtc aatgcacaca gaatacaacc 1500 tcatgctccc tgcagcaaga cccctgaaag tgattcatgc ttctggctgg cattctgcat 1560 gtttagtgat tgtcttggga atgtttcact gctacccgca tccagcgact gcagcaccag 1620 aaaacgacta atgtaactat gcagagttgt ttggacttct tcctgtgcca ggtccaagtc 1680 gggggacctg aagaatcaat ctgtgtgagt ctgtttttca aaatgaaata aaacacacta 1740 ttctctggc 1749 <210> 35 <211> 2320 <212> DNA <213> Human <400> 35 ctcagctgca gttctctgat ggcttgcaca gggtggacca gcccccttcc tctatgtgtg 60 tgtctgctgc tgacctgtgg ctttgccgag gcagggaagc tactggtagt gcccatggat 120 gggagccact ggttcaccat gaggtcggtg gtggagaaac tcattctcag ggggcatgag 180 gtggttgtag tcatgccaga ggtgagttgg caactgggaa gatcactgaa ttgcacagtg 240 aagacttatt caacttcata taccctggag gatctggacc gggagttcaa ggcttttgcc 300 catgctcaat ggaaagcaca agtacgaagt atatattctc tattaatggg ttcatacaat 360 gacatttttg acttattttt ttcaaattgc aggagtttgt ttaaagacaa aaaattagta 420 gaatacttaa aggagagttc ttttgatgca gtgtttctcg atccttttga taactgtggc 480 ttaattgttg ccaaatattt ctccctcccc tccgtggtct tcgccagggg aatactttgc 540 cactatcttg aagaaggtgc acagtgccct gctcctcttt cctatgtccc cagaattctc 600 ttagggttct cagatgccat gactttcaag gagagagtac ggaaccacat catgcacttg 660 gaggaacatt tattatgcca ccgttttttc aaaaatgccc tagaaatagc ctctgaaatt 720 ctccaaacac ctgttacgga gtatgatctc tacagccaca catcaatttg gttgttgcga 780 acggactttg ttttggacta tcccaaaccc gtgatgccca acatgatctt cattggtggt 840 atcaactgcc atcagggaaa gccgttgcct atggaatttg aagcctacat taatgcttct 900 ggagaacatg gaattgtggt tttctctttg ggatcaatgg tctcagaaat tccagagaag 960 aaagctatgg caattgctga tgctttgggc aaaatccctc agacagtcct gtggcggtac 1020 actggaaccc gaccatcgaa tcttgcgaac aacacgatac ttgttaagtg gctaccccaa 1080 aacgatctgc ttggtcaccc gatgacccgt gcctttatca cccatgctgg ttcccatggt 1140 gtttatgaaa gcatatgcaa tggcgttccc atggtgatga tgcccttgtt tggtgatcag 1200 atggacaatg caaagcgcat ggagactaag ggagctggag tgaccctgaa tgttctggaa 1260 atgacttctg aagatttaga aaatgctcta aaagcagtca tcaatgacaa aagttacaag 1320 gagaacatca tgcgcctctc cagccttcac aaggaccgcc cggtggagcc gctggacctg 1380 gccgtgttct gggtggagtt tgtgatgagg cacaagggcg cgccacacct gcgccccgca 1440 gcccacgacc tcacctggta ccagtaccat tccttggacg tgattggttt cctcttggcc 1500 gtcgtgctga cagtggcctt catcaccttt aaatgttgtg cttatggcta ccggaaatgc 1560 ttggggaaaa aagggcgagt taagaaagcc cacaaatcca agacccattg agaagtgggt 1620 gggaaataag gtaaaatttt gaaccattcc ctagtcattt ccaaacttga aaacagaatc 1680 agtgttaaat tcattttatt cttattaagg aaatactttg cataaattaa tcagccccag 1740 agtgctttaa aaaattctct taaataaaaa taatagactc gctagtcagt aaagatattt 1800 gaatatgtat cgtgccccct ccggtgtctt tgatcaggat gacatgtgcc atttttcaga 1860 ggacgtgcag acaggctggc attctagatt acttttctta ctctgaaaca tggcctgttt 1920 gggagtgcgg gattcaaagg tggtcccacc gctgccccta ctgcaaatgg cagttttaat 1980 cttatctttt ggcttctgca gatggttgca attgatcctt aaccaataat ggtcagtcct 2040 catctctgtc ctgcttcata ggtgccacct tgtgtgttta aagaagggaa gctttgtacc 2100 tttagagtgt aggtgaaatg aatgaatggc ttggagtgca ctgagaacag catatgattt 2160 cttgctttgg ggaaaaagaa tgatgctatg aaattggtgg gtggtgtatt tgagaagata 2220 atcattgctt atgtcaaatg gagctgaatt tgataaaaac ccaaaataca gctatgaagt 2280 gctgggcaag tttacttttt ttctgatgtt tcctacaact 2320 <210> 36 <211> 2722 <212> DNA <213> Human <400> 36 catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc 60 acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag 120 gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt 180 tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa 240 cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag 300 tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga 360 tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc 420 cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga 480 gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt 540 cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc 600 atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta 660 accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat 720 cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa 780 ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact 840 tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg 900 cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat 960 tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta 1020 cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg 1080 gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa 1140 aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct 1200 tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc 1260 aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg 1320 cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga 1380 acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc 1440 ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc 1500 tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa 1560 ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg 1620 ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg 1680 gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg 1740 ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg 1800 ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta 1860 ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg 1920 gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc 1980 aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca 2040 aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga 2100 gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt 2160 tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac 2220 cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct 2280 cagcctcaga gtcagatgca ggaggaagac acagcaccct ggagatgtta aggcagaagt 2340 cagttcttct gtccatccct ctccccagcc aggatagagc tatcttttcc atctcatcct 2400 cagaagagac tcagaagaaa gatgacagcc ctcagaatgc acgttatgag gaaggcagaa 2460 tgtgggtctg taattcctcc gtgtcccttc tccccctctg caaaccgtcg taacaataat 2520 agttcctaac acatgggaca attgtgagga ttaaatgagt tagcctgcag aaatcacttg 2580 atgcacagca catgggaagc attgtgtgta tttattaatc cttcacaaag tctttgagat 2640 atatttttat caaatattta gcatggatcc cggtacactt tcaatactta ataaatggtc 2700 aatgttattc tttttcacta tt 2722 <210> 37 <211> 631 <212> DNA <213> Human <220> <221> misc_feature <222> (524)..(524) <223> any kind of base <220> <221> misc_feature <222> (592)..(592) <223> any kind of base <220> <221> misc_feature <222> (547)..(547) <223> any kind of base <220> <221> misc_feature <222> (600)..(600) <223> any kind of base <220> <221> misc_feature <222> (519)..(519) <223> any kind of base <400> 37 ttattctcta ccttgttcca catctggcat tttttgtgca tcttccaact taagtacaca 60 gcagcaagtg ctctacatct ttgggtagct acacagaacc ccactgtggc tcactgtgga 120 cacaccattg aaaaccttgt atgtaggtca cttagtacaa ggaggaacac aactgttgaa 180 gaagtaccta aaaattgaat tacttgaaca aagtgtggga catttgctgt tttgatggat 240 tttaccacac tgtcttccca tttatgctta ccagcaatac ataggaacac ttgggtccct 300 gcagtcaggg tgtggaaatg gcagatgagt tcagccctaa ggtgcatttt tcttactagg 360 aggagatgga gtgtatttta tgggatataa gcattagcta catttcctgt cctgttcaca 420 tcctttgccc atgtgtctat gaggttattg atctttctta ctgatttatt ggtagctctt 480 acttaagagg taattagcct tttgcctgtg gagagtttnt tgtnttgcca tttgtccttt 540 tttaatnttt tttggttatt ggcccatttg tcttttggac tctgatgtgg tnttgctgan 600 ttcctttgat gtattctagt tatctgactt t 631 <210> 38 <211> 1761 <212> DNA <213> Human <400> 38 gtttagagta ctaggttatt tatgttttac aaagtttgaa tcttctataa actaagaaag 60 gggatgatcc ttagatttgc attaaaatat agaagtcttt taaagtaaat gtgaaccttg 120 tctaagtact gtaatccaca caacacatta taagaagcaa accagcatct taaggaatta 180 taaaattacc ctatttaaaa gccatgctat tgttctgcta ttaccagatt tattgtgcca 240 cacaaaagga tcatgtgtgt cagcaggggc cgtttggaac aaacctagtc attaatgagt 300 aagatactcc tgttagttca gggaccaagt tttatgaccc agaggcttaa tgatgtttgg 360 atatatttca aatcggcgtg cttacctcac tgatttaaat tattttctaa atagtggcca 420 ttgtagacct gactcaggct gaagctaaat agagaacaat ttagaaagtt aactaacaat 480 acagtgcatt ctacccgtag gcccaccatg cccttctgcc cctggctgat ttgatcctgt 540 gtctgatccc attgcaccct gactgggcag tccctacaga accagtgtta atttgaaggg 600 cctccactca ggctccaaat gtggcagcca aagagaacaa tccagggaac ctacatttat 660 ttttaaggac aaatatttcc tcctcagtgg tcctaatgtt cagggcttta gagggaaccc 720 aggtggtctc ttcaccctgt gtcctagaat gggagagtaa gtagacagtg gtgataaccc 780 cacactgctt ataagtgcat ctttatagta tttggggctt tcctacccct ttagccttct 840 gtacctagta ccatattcca gttttaaaga actggcagaa tgtgatggat aacagaggaa 900 gagctcaatt tatgtttatt ggaagaacat tttacttaaa tgatttgagg ggtgggaggg 960 agtgaactac tgagtttgcc agagtgaaaa tccatctgaa aaactcagct acctttagtt 1020 tttagtcctc atttttggtc ttgtctctgc ggactgtgaa gaatcacaat gctctatatg 1080 ccctggactg tgtggcaaat gcaggttgca gcgtgtgtgt tacatgagga tcttccacaa 1140 tttcagaatg cacgccagag ctgaaggggg aaacttggta acttgcccat tattctctgc 1200 ttttagccag agttaaacag actgatgggt ctggtagcca acaacttggc aacttccact 1260 ccttctcacc tcgtgagatt aagggctgtg aaaagaaatc tagtctaact ccaacagaaa 1320 tctgtctctg ttaagtgttt taccttctgt aagtagagat ggtagagcca agatttttct 1380 tttggtaatt tccctgtcta taaagtgaga ccaaagggat atctgttccc tgttaccttt 1440 ttggagaatt cataacattt gaagatcaaa aaattgaatg ataaatatga atggcttttc 1500 aattctgtgg actttgtacc atttggcttc accttgtact gcaagatgaa tttgtaaaca 1560 aaacaaaatt ggactgtctg gaaagctaaa gttctgaaat atggaatgta ctgcctctaa 1620 tttttctttg tcttcctctc actggcattt ttttctctcc caggtttctt aagaataatg 1680 ttttttaaag gaggcttttt gcccatcaag aataaaaaga aataaaacca aagggttacc 1740 ggaaaaaaaa aaaaaaaaaa a 1761 <210> 39 <211> 2414 <212> DNA <213> Human <400> 39 ggggtgaggg cagcagctcg ccacagctgc cagccatctg tccattcacc catctgtcca 60 tctggcagcc cgctgttcag acctgtctgt ctgtccgccc atctctgtaa gcccatctct 120 gtcccattgt ctatctgacc atctttctct tactgtcctc tttgtctagc tatctggcct 180 atctgtcgat ccatcttcgt gtctgtcttc agcccccacc tgtttttgtc catctgtcca 240 attacctgtg actctgtgca tcttcttgtc cattcatctg cccacccatc cgtccctccg 300 tctgcccacc agccgcccct ctcctcctgg gctgcagagc catggcccgg ggctacgggg 360 ccacggtcag cctagtcctg ctgggtctgg ggctggcgct ggctgtcatt gtgctggctg 420 tggtcctctc tcgacaccag gccccatgtg gcccccaggc ctttgcccac gctgctgttg 480 ccgccgactc caaggtctgc tcggatattg gacgagccat cctccagcag cagggctcac 540 ccgtggatgc caccatcgcg gctctggtct gcaccagcgt cgtcaaccct cagagcatgg 600 gcctgggcgg aggggtcatc ttcaccatct acaatgtgac aacagggaag gtggaggtca 660 tcaatgcccg ggagacggtg ccggccagcc acgccccgag cctgctggac cagtgtgcac 720 aggctctgcc actgggcaca ggggcccagt ggatcggggt gcccggggag ctccgtggct 780 atgccgaggc ccaccgccgc catggccgcc tgccctgggc gcagctgttc cagcccacca 840 tcgcgctgct ccgagggggg catgtggtgg cccctgtcct cagccgtttc ctgcacaaca 900 gcatcctgcg gccttccttg caggcgtcaa ccctgcgcca gctcttcttc aacgggacag 960 aacccctgag gcctcaggac ccactcccat ggcctgcact ggccaccacc ctggagaccg 1020 tggccacaga gggcgtggag gtcttctaca cggggaggct gggccagatg ctggtggagg 1080 acattgccaa ggaagggagc cagctgacgc tgcaggacct ggccaagttc cagcccgagg 1140 tggtggatgc cctggaggtg cccctggggg actataccct gtactcacca ccgccgcctg 1200 cagggggtgc cattctcagc tttatcctca acgtgctaag agggttcaac ttctcaacag 1260 agtctatggc caggcctgaa gggagggtga acgtgtacca ccaccttgta gagacgctca 1320 agtttgccag ggggcagagg tggaggctgg gggaccctcg aagccacccg aagctccaga 1380 atgcctcccg ggacctgctg ggggagaccc tggcccagct catccgccaa cagatcgatg 1440 gccgggggga ccaccagctc agccactaca gcttggccga ggcctggggc cacgggacag 1500 gcacgtccca tgtgtctgtg ctgggggagg atggcagcgc cgtggctgcc accagcacca 1560 tcaacacacc ctttggagcg atggtgtatt caccacggac aggcatcatc ctcaacaacg 1620 agctcctgga cttatgcgag cgatgcccct ggggttccgg caccaccccc tcacctgtga 1680 gtggagacag ggtgggtgga gctcccggaa ggtgctggcc cccagttcca ggcgagcgtt 1740 ccccatcctc catggtgccc tccatcttga tcaacaaagc ccaggggtcg aagctagtga 1800 ttggcggggc tggcggggag ctcatcatct ctgctgtggc ccaggccatc atgagcaagc 1860 tgtggcttgg ctttgacctg agagcggcca ttgcagcccc catcctgcat gtcaacagca 1920 agggctgtgt ggagtacgag cccaacttca gccaggaggt gcagagggga ctccaagacc 1980 gtggccagaa ccagacccag aggcccttct tcctgaacgt ggtccaggct gtgtcccagg 2040 agggggcctg tgtgtacgcc gtctcggacc tgaggaagag tggggaggcc gcaggctact 2100 aagacactgc tctgcccaga gctgaagtct ggccccacca tgagtcctgt gtccaggccg 2160 gacatggctg ggggaccaac tactctggca ggatctggac ccctggcagg ggagtccagc 2220 tgagagtgga agaggtggcg gggaccagct gggcagatga gaggctgagc ctcatcccta 2280 accccctttc ccagagcccc tggtggtcct gaaccggccc ctctatccct ccgcaggcct 2340 cttacctggg gccactctcc caccctctcg atctgtatat cctccagtcc aagattaaag 2400 aagaggcgga ctgt 2414 <210> 40 <211> 2146 <212> DNA <213> Human <400> 40 cggggacggt gcgccagtgc cccctccgcg agccccaacc agtagacggt tccctgtctc 60 ccgcgcccca atttcgattt tcaaacgcaa ctcctacagg attctgagac cccgtcccat 120 ctcccatatc ccatttccag ctgcaaatta ctgcagaatc tgaacccagg aaagaaaccc 180 atttgccgac cccctcttcc ctctccagac aggtggagag cgggtgaggg tctcgctcgg 240 ctttccccct gcacctttcc caccctcccg cccgtccctg ggggtcctcc gtcaccgcgg 300 ccatggccca gaagccgaag gtggaccccc acgtcgggcg gctgggatac ctgcaggcgc 360 tggtcacgga attccaggag acccaaagcc aagacgccaa ggagcaagtc ctcgccaacc 420 tcgccaactt cgcttatgac cccagcaact acgagtatct gcggcagctg caggtcctgg 480 atttatttct cgattcgctg tcggaggaga atgagaccct ggtggagttt gctattggag 540 gcctgtgcaa cctgtgccca gacagggcca acaaggagca catcctgcac gcaggaggtg 600 tcccactcat catcaactgc ctatccagcc ccaatgagga gacggtgctg tctgccatca 660 ccacgctcat gcacctgagc ccgccgggcc gcagctttct cccagagctg accgccacgc 720 ccgtggtgca gtgcatgctt cgcttctccc tctcggccag cgccaggctc cggaacctgg 780 cacagatctt cctggaggac ttctgctccc cccgccaggt ggccgaggcc cgcagccggc 840 aggcgcactc tgccctgggt atcccactgc cgaggagcgt ggccccacgg cagcgctgat 900 ccatggagac tgcgagaccg tggcacccct actgctgggg accacagtcc tgatgtggac 960 gcagggaacg gggagcacat actgccccat tggtgccttt tcagccatct gaaaggcggg 1020 ttctttcagc aggacaggca tttacactga tgaaacgcca ctgggagtga ggaagccaga 1080 ctccagagac acggagaaga tcaaactgga gctgcgttca taggctggca ctctcaatcc 1140 tacatcaggt gccaccacca ccagactcag gccctggtgt aagaagcggc caagtgcctg 1200 gacccagagg ctttgcagga cagtgttctc aggagctggg cctgaggctt aggagagctg 1260 ccttcgctgc aggaaatcag ggattatccc ttaacagaag tgtctggagt agttttcagg 1320 tataggaatg agatgcctcg tggtgaaagg atctcaccct gggaagatgt ggtgccccct 1380 ccagggctct ggaggatgga tgcctccccc aggggctctc caagctgggc atttgggcct 1440 ggtggatgcc aacctggata acctgtggcc cagcattgac tgtccaccca gccttgctgt 1500 taggcaccat gactccaaga tgaagatgtg gtccctgccc ttgagtgaca gcccagggac 1560 ttaatgtggc catcgggcat caagcacaag gccatgcagg tgatgatacg tcggaataga 1620 ggcaccagcc ctggtaactg catcttctcc ccttgccacc ccatggcccc ggctgaaagc 1680 ttcggccctc ctctgctgtc actcaatgat ggggagccct accccagaag tgtatcccac 1740 gagggcatca gggacgcagt gagtgttgct caagggagtc aggaagagac ggcaacgtaa 1800 aggatgtggc tccatgtcca tggtgccccc tggtcaacat aaggagcgtg ggatccgatg 1860 gaaaggtgga gctcagggaa aatgggggtc cttgcctctc gtgtaccccc tcaaggctga 1920 ccccttagat ggcccaggaa tggcaggtgc tacaaaaatg gtacccacgt gggcatggaa 1980 atggggcaga ttaggggacc actggactca gaggggaggg aagggctcat cagcacccgc 2040 tcagggagcc tgtcccttta tgttcccaaa taaagggtcc tagaagacta gaaagccaag 2100 gtcttttatt aaaggtcccg actggtaaaa aaaaaaaaaa aaaaaa 2146 <210> 41 <211> 8789 <212> DNA <213> Human <400> 41 atgtctgaca aaatgtcgag tttcctacat attggagaca tttgttctct gtacgcggag 60 ggatcgacaa atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag 120 ccagaaaccg gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta 180 tgtcccatga accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc 240 aacagcacca cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag 300 aagcagaatg agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg 360 atccagctcc tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct 420 ctgttggaga agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg 480 ttttatattc agccattcta caagctgcga tccattggag acagcgtggt cataggtgac 540 aaggtggttc tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg 600 gtagataacc caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata 660 gtccttttca tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg 720 aggctgtttc atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag 780 cacgtcttcc tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc 840 ctgtgggagg tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac 900 agccttttcc gtttcaagca tctggccacg gggcattact tggcagcaga ggtggaccct 960 gatcaggacg cctctcgaag taggttgcgg aatgcccaag aaaagatggt atactccctg 1020 gtctctgtgc ctgaaggcaa tgacatctcc tccattttcg agctagatcc caccactctg 1080 cgtggaggtg acagccttgt cccaaggaac tcttatgttc ggctcagaca cctatgtact 1140 aatacctggg ttcacagcac aaatattcct attgacaagg aagaagaaaa gcccgtgatg 1200 ctgaaaattg gcacctctcc tgtgaaggag gataaggaag catttgccat agttccggtt 1260 tctcctgctg aagttcggga cctggacttc gccaatgatg ccagcaaggt gctgggctcc 1320 attgctggga agctagagaa gggcaccatc acccagaatg aaaggaggtc tgtaaccaag 1380 ctgctagaag atttggttta cttcgtcact ggtggaacta attctggtca agatgttctc 1440 gaagttgtct tctccaagcc caacagagaa cggcagaaac tgatgagaga acagaatatt 1500 ctcaagcaga tcttcaagtt gttacaagcc ccattcacag actgcggtga tggcccaatg 1560 cttcggctgg aagagctcgg ggaccagcgg cacgctcctt tcagacacat ctgccggctc 1620 tgctacaggg tgctgagaca ctcgcagcaa gactacagga agaaccagga gtatatagcc 1680 aagcagtttg gcttcatgca gaagcagatt ggctatgatg tgttggctga agacactatc 1740 actgccctgc tccacaataa tcggaaactc ctggaaaaac acattaccgc ggcagagatt 1800 gacacatttg tcagcctggt gcgaaagaac agggagccca gattcttaga ttacctctcc 1860 gacctctgtg tctccatgaa caaatcaatt ccagtgaccc aggaactgat atgtaaagct 1920 gtgctgaacc ccaccaacgc tgacatcctg attgagacca aattggttct ttctcgtttt 1980 gaatttgaag gtgtctcttc cactggagag aatgctctgg aggcaggaga agacgaggaa 2040 gaggtgtggc tgttttggag ggacagcaac aaagagattc gcagcaagag tgtgagggaa 2100 ttggctcagg atgctaaaga agggcagaag gaggaccgag acgttctcag ctactacaga 2160 tatcagctga acctctttgc gaggatgtgt ctggaccgcc aatacctggc catcaacgaa 2220 atctcaggcc agctggatgt cgatctcatt ctccgctgca tgtctgacga gaacctgccc 2280 tatgacctca gggcgtcctt ctgccgcctc atgcttcaca tgcatgtgga ccgagatccc 2340 caggaacaag tcacccccgt gaaatatgcc cgcctctggt cggagattcc ctcggagatc 2400 gccattgacg actatgatag tagtggagct tccaaagatg aaattaagga gagatttgct 2460 cagaccatgg agtttgtgga ggagtattta agagatgtgg tttgtcagag gttccctttc 2520 tctgataaag agaagaataa gcttacgttt gaggttgtaa atttagctag gaatctcata 2580 tactttggtt tctacaactt ctctgacctt ctacgattaa ctaagatcct tctggccata 2640 ttggactgtg tacatgtgac aacaatcttc cccattagca agatggcgaa aggagaagag 2700 aataaaggta acaatgatgt ggagaagctg aagagcagta acgtgatgag atctattcat 2760 ggcgtgggag agctgatgac ccaggtggtg ctccggggag gaggcttttt gcccatgact 2820 cccatggctg ctgcccctga aggcaatgtg aagcaggcag agcctgagaa ggaggacatc 2880 atggtcatgg acaccaagct gaagatcatt gagatactcc agtttatttt gaatgtgagg 2940 ttggattata ggatctcctg cctcctgtgt atatttaagc gagagtttga tgaaagcaat 3000 tcccagactt cagaaacatc ctccggaaac agcagccaag aagggccaag taatgtacca 3060 ggtgctcttg actttgaaca cattgaagaa caagcagaag gcatctttgg aggaagtgag 3120 gagaacaccc cactggactt ggatgaccac ggcggcagaa cctttctccg tgtcctgctc 3180 cacttgacga tgcatgacta cccacccctg gtgtcagggg ccctgcagct cctcttccgg 3240 cacttcagcc agaggcagga ggtgctccag gccttcaaac aggttcaact gctggttacc 3300 agccaagatg tggacaacta caaacagatc aaacaagact tggatcaact gaggtccatc 3360 gtggaaaagt cagagctttg ggtgtacaaa gggcagggcc ccgatgagac tatggatggt 3420 gcatctggag aaaatgaaca taagaaaacg gaggagggaa ataacaagcc acaaaagcat 3480 gaaagcacca gcagctacaa ctacagagtg gtcaaagaga ttttgattcg gcttagcaaa 3540 ctctgtgttc aagagagtgc ctcagtgaga aagagcagga agcagcaaca gcgtctgctc 3600 cggaacatgg gcgcgcacgc cgtggtgctg gagctgctgc agattcccta tgagaaggcc 3660 gaagatacca agatgcaaga gataatgagg ttggctcatg aatttttgca gaatttctgc 3720 gcaggcaacc agcagaatca agctttgcta cataaacaca taaacctgtt tctcaaccca 3780 gggatcctgg aggcagtaac catgcagcac atcttcatga acaatttcca gctttgcagt 3840 gagatcaacg agagagttgt tcagcacttc gttcactgca tagagactca cggtcggaat 3900 gtccagtata taaagttctt acagacaatt gtcaaggcag aagggaaatt tattaaaaaa 3960 tgccaagaca tggttatggc cgagctggtc aattcgggag aggatgtcct cgtgttctac 4020 aacgacagag cctctttcca gactctgatc cagatgatgc ggtcagaacg ggatcggatg 4080 gatgagaaca gccctctcat gtaccacatc cacttggtcg agctcctggc tgtgtgcacg 4140 gagggtaaga atgtctacac agagatcaag tgcaactccc tgctcccgct ggatgacatc 4200 gttcgcgtgg tgacccacga ggactgcatc cctgaggtta aaattgcata cattaacttc 4260 ctgaatcact gctatgtgga tacagaggtg gaaatgaagg agatttatac cagcaatcac 4320 atgtggaaat tgtttgagaa tttccttgta gacatctgca gggcctgtaa caacactagt 4380 gacaggaaac atgcagactc gattttggag aagtatgtca ccgaaatcgt catgagtatt 4440 gttactactt tcttcagctc tcccttctca gaccagagta cgactttgca gactcgccag 4500 cctgtctttg tgcaactgct gcaaggcgtg ttcagggttt accactgcaa ctggttaatg 4560 ccaagccaaa aagcctccgt ggagagctgt attcgggtgc tgtctgatgt agccaagagc 4620 cgggccattg ccattcccgt ggacctggac agccaagtca acaacctctt tctcaagtcc 4680 cacagcattg tgcagaaaac agccatgaac tggcggctct cagcccgcaa tgccgcacgc 4740 agggactctg ttctggcagc ttccagagac taccggaata tcattgagag attgcaggac 4800 atcgtctccg cgctggagga ccgtctcagg cccctggtgc aggcagagtt atctgtgctc 4860 gtggatgttc tccacagacc cgagctgctt ttcccagaga acacagacgc cagaaggaaa 4920 tgtgaaagtg gcggtttcat ttgcaagtta ataaagcata caaaacagct gctagaagaa 4980 aatgaagaga agctctgcat taaggtccta cagaccctga gggaaatgat gaccaaagat 5040 agaggctatg gagaaaagct aatttccatt gatgaattgg ataatgctga gcttcctcca 5100 gctccggatt ctgagaacgc cactgaggag cttgaaccaa gtccacccct gcggcagctg 5160 gaagaccata aaaggggtga ggcgctcagg caagttctgg tcaaccgtta ctatggaaac 5220 gtcagacctt cgggacgaag agagagcctt accagctttg gcaatggccc actgtcagca 5280 ggaggacccg gcaagcccgg gggaggaggg ggaggttccg gatccagctc tatgagcagg 5340 ggtgagatga gtctggccga ggttcagtgt caccttgaca aggagggggc ttccaatcta 5400 gttatcgacc tcatcatgaa cgcatccagt gaccgagtgt tccatgaaag cattctcctg 5460 gccattgccc ttctggaagg aggcaacacc accatccagc actccttttt ctgtcgcttg 5520 acagaagata agaagtcaga gaaattcttt aaggtgtttt atgaccggat gaaggtggcc 5580 cagcaagaaa tcaaagcaac agtgacagtg aacaccagtg acttgggaaa taaaaagaaa 5640 gacgatgagg tagacaggga tgccccatca cggaaaaaag ctaaagagcc cacaacacag 5700 ataacagaag aggtccggga tcagctcctg gaggcctccg ctgccaccag gaaagccttc 5760 accactttca ggagggaggc tgatcccgac gaccactacc agcctggaga gggcacccag 5820 gccactgccg acaaggccaa ggacgacctg gagatgagcg cggtcatcac catcatgcag 5880 cccatcctcc gcttccttca gctcctgtgt gaaaaccaca accgagacct gcagaacttc 5940 ctccgttgcc aaaataacaa gaccaactac aatttggtat gtgagaccct gcagtttctg 6000 gactgtattt gtggaagcac aactggaggc cttggtcttc tgggcttgta tataaatgaa 6060 aagaacgtag cgcttatcaa ccaaaccctg gaaagtctga ccgaatactg tcaaggacct 6120 tgccatgaga accagaactg catagccacc catgaatcca atggcattga catcatcaca 6180 gccctgatcc tcaatgatat caatcctttg ggaaagaaga ggatggacct tgtgttagaa 6240 ctgaagaaca atgcctcgaa gttgctcctg gccatcatgg aaagcaggca cgacagtgaa 6300 aacgcagaga ggatacttta taacatgagg cccaaggaac tggtggaagt gatcaagaaa 6360 gcctacatgc aaggtgaagt ggaatttgag gatggagaaa acggtgagga tggggcggcg 6420 tcccccagga acgtggggca caacatctac atattagccc atcagttggc tcggcataac 6480 aaagaacttc agagcatgct gaaacctggt ggccaagtgg acggagatga agccctggag 6540 ttttatgcca agcacacggc gcagatagag attgtcagat tagaccgaac aatggaacag 6600 atagtctttc ccgtgcccag catatgtgaa ttcctaacca aggagtcaaa actacgaatt 6660 tactatacta cggagagaga cgaacaaggc agcaaaatca atgatttctt tctgcggtct 6720 gaagacctct tcaatgaaat gaattggcag aagaaactga gagcccagcc cgtgttgtac 6780 tggtgtgccc gcaacatgtc tttctggagc agcatttcgt ttaacctggc cgtcctgatg 6840 aacctgctgg tggcgttttt ctacccgttt aagggagtcc gaggaggaac cctggagccc 6900 cactggtcgg gactcctgtg gacagccatg ctcatctctc tggccatcgt cattgccctc 6960 cccaagcccc atggcatccg ggccttaatt gcctccacaa ttctacgatt gatattttca 7020 gtcgggttac aacccacgtt gtttcttctg ggcgctttca atgtatgcaa taaaatcatc 7080 tttctaatga gctttgtggg caactgtggg acattcacaa gaggctaccg agccatggtt 7140 ctggatgttg agttcctcta tcacttgttg tatctggtga tctgtgccat ggggctcttt 7200 gtccatgaat tcttctacag tctgctgctt tttgatttag tgtacagaga agagactttg 7260 cttaatgtca ttaaaagtgt cactcgcaat ggacgggcca tcatcctgac agcagttctg 7320 gctctgatcc tcgtttacct gttctcaata gtgggctatc ttttcttcaa ggatgacttt 7380 atcttggaag tagataggct gcccaatgaa acagctgttc cagaaaccgg cgagagtttg 7440 gcaagcgagt tcctgttctc cgatgtgtgt agggtggaga gtggggagaa ctgctcctct 7500 cctgcaccca gagaagagct ggtccctgca gaagagacgg aacaggataa agagcacaca 7560 tgtgagacgc tgctgatgtg cattgtcact gtgctgagtc acgggctgcg gagcgggggt 7620 ggagtaggag atgtactcag gaagccgtcc aaagaggaac ccctgtttgc tgctagagtt 7680 atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg 7740 gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg 7800 aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc 7860 tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg 7920 gtgaaagtaa aggactccac cgaatatact gggcctgaga gttacgtggc agaaatgatc 7980 aaggaaagaa accttgactg gttccccagg atgagagcca tgtcattggt cagcagtgat 8040 tctgaaggag aacagaatga gctgagaaac ctgcaggaga agctggagtc caccatgaaa 8100 cttgtcacga acctttctgg ccagctgtcg gaattaaagg atcagatgac agaacaaagg 8160 aagcagaaac aaagaattgg tcttctagga catcctcctc acatgaatgt caacccacaa 8220 caaccagcat aagcaaatga aagaaaggaa ttgtatttac cttttataat tattattagt 8280 gtgggaatgg ctaatgagtt ctgattcacc cacgaaggtt acatttatgc tgaatacatt 8340 tgtaaatact cagttttata ctgtatgtat atgattgcta ctctaaaggt ttggatatat 8400 gtattgtaat tagaattgtt ggcatgatga catttcattt gtgccaaaaa tattaaaaat 8460 gccttttttg gaaggactaa cagaaagcac ctgatttgca cttgaaccag attatagatt 8520 taaaagtata tgacatgtat tttgtattta aaactagaat agccagtatt tatgtttttt 8580 ataaaactgt gcaatacgaa ttatgcaatc acaatacatt tgtagctccc gagtgtccta 8640 aagggagtgc acttctttga agctggtgtg ttaatactat gtaataaatg gttaactttc 8700 aaatgatgct gctgccaaaa ttatattaat agagagtttc aggcccctgg gaattcctgc 8760 agcccggggg atccccgggt accgagctc 8789 <210> 42 <211> 4394 <212> DNA <213> Human <400> 42 aaactcccag ggcccgccca ggacccccaa gccgccgcgg acgcagccca ggatggcggc 60 ccaggtgact ctggaggacg cgctgtccaa cgtggacctc ctggaggagc tgcccctgcc 120 cgaccagcag ccctgcatcg agcccccgcc atcctcgctg ctctaccagc caaatttcaa 180 cactaacttt gaagacagaa atgcatttgt tactggcatc gcaagataca ttgaacaagc 240 caccgtccac tctagcatga acgagatgct ggaggagggc caagaatatg ctgtcatgct 300 gtacacctgg aggagctgct cccgggccat cccacaggtg aaatgtaacg agcagcctaa 360 cagagtggaa atctacgaga aaaccgtgga ggttctggag cctgaggtca caaaactgat 420 gaatttcatg tacttccaga gaaatgccat tgagcgtttc tgcggggaag tgaggcgcct 480 gtgccatgcc gagaggagga aggacttcgt gtcagaagcc tacctgatca cactgggcaa 540 attcatcaac atgttcgctg tgctggacga gctgaagaac atgaagtgca gtgtgaagaa 600 cgaccactca gcgtacaaga gggccgctca gtttttacgt aaaatggcag atccacagtc 660 catccaggaa tcgcagaatc tgtccatgtt cctggccaat cataacaaga tcacacagtc 720 tctgcagcag cagctcgaag tgatttctgg ctacgaagag ctcctggcag atattgtgaa 780 tctgtgtgtg gattactacg agaacaggat gtatttgacg cccagtgaga aacacatgct 840 tctcaaagtc atgggatttg gtctgtacct gatggatggg agtgtcagta acatctataa 900 gttggatgcc aagaaaagaa taaacttatc caaaatcgac aagtacttca agcaactcca 960 ggtggttcca ctatttgggg acatgcaaat agaactggca agatatatca agaccagcgc 1020 ccactacgag gaaaataaat ctcgatggac gtgcacatcc tccggcagca gccctcagta 1080 caacatctgc gagcagatga tccagatccg cgaggaccac atgcgcttca tttcggagct 1140 ggcgcgctac agcaacagcg aggtggtcac gggctcgggc cgccaggagg cccagaagac 1200 ggacgcggag taccgcaagc tcttcgacct ggcgctgcag ggcctgcagc tgttgtcgca 1260 gtggagcgcg cacgtgatgg aagtgtattc ctggaagctt gtgcacccca ccgacaagta 1320 ctccaacaag gactgccccg acagcgctga agagtacgag cgtgccacgc gctacaacta 1380 caccagcgag gagaagtttg ccctagtgga ggtgatcgcc atgatcaaag gcctgcaggt 1440 gctgatgggc aggatggaga gcgtgttcaa ccacgccatc cggcacaccg tctatgccgc 1500 actgcaggac ttctcccagg tgacccttag ggagccgctg cggcaggcca tcaagaagaa 1560 gaagaacgtc atccagagtg tcctgcaggc catcaggaag accgtgtgtg actgggagac 1620 ggggcatgag cccttcaatg acccagcctt gcggggcgag aaggacccca agagcggctt 1680 cgacataaaa gtaccacgcc gcgccgtggg accctccagc actcagcttt acatggtgag 1740 aaccatgcta gagtccctca ttgcagacaa aagtggttcc aagaaaacct tgagaagtag 1800 ccttgagggg cccaccatat tggacataga aaaatttcat cgagagtcat tcttctacac 1860 tcacttgata aatttcagtg aaacgctgca gcagtgctgt gacctttcgc agctgtggtt 1920 ccgagagttc ttcctggagc tgaccatggg caggaggatc cagttcccca ttgagatgtc 1980 gatgccctgg atcctgacgg accacatcct ggagaccaag gaggcatcga tgatggagta 2040 cgtgctctac tccctggacc tgtacaatga cagcgcccac tacgcgctca ccaggttcaa 2100 caagcagttc ctgtacgacg aaattgaggc cgaggtgaat ctatgttttg accaatttgt 2160 ttacaagcta gcagaccaga tatttgccta ttataaggtt atggcaggaa gtttgcttct 2220 tgataaacgg ttacgatcag aatgcaagaa tcagggagcc acgatccacc tcccgccgtc 2280 taaccgctac gagacgctgc tgaagcagag gcatgtgcag ctcctcggca gatcaataga 2340 cctcaatcgt ctgatcaccc agcgcgtctc agcagccatg tataagtccc tagaactggc 2400 gattggacga tttgaaagtg aagatttgac ctccatagtt gagctggatg gcctgttgga 2460 aatcaaccgc atgacccaca agctgctgag ccggtacctg acgctggacg gcttcgacgc 2520 catgttccgg gaggccaacc acaacgtgtc agcgccctac gggaggatca ccctgcacgt 2580 cttctgggag ctcaactatg acttcctgcc caactactgc tacaacggct ctaccaaccg 2640 gtttgttcgg acagtgttac cattttctca ggaatttcaa agagataagc agcctaatgc 2700 acagcctcag tatctgcatg gatccaaggc tttgaacttg gcctactcca gcatttacgg 2760 cagctaccgg aacttcgtgg gacctccaca ctttcaagtc atctgccggc ttctcggcta 2820 ccagggtatc gccgtggtca tggaggagct gctgaaggtc gtcaagagcc tgctgcaagg 2880 cacaatcctg cagtacgtga agacgctgat ggaggtgatg cccaagatct gccgcctgcc 2940 ccggcacgag tacggctctc ctggtatcct ggagttcttc caccaccagc tgaaggacat 3000 cgtggagtac gcagagctga agacggtgtg cttccagaac ctgcgggagg tggggaacgc 3060 catcctcttc tgcctgctca tcgagcagag cctgtcttta gaagaagtgt gtgacctgct 3120 gcacgcggct cctttccaga acatcttgcc gcgagtccat gtgaaagagg gggagagact 3180 tgatgccaaa atgaaaagac tagaatcaaa gtacgccccg ctgcatcttg tcccactgat 3240 tgaaagactg gggacccctc agcaaattgc catcgcaaga gagggggacc tgctgacaaa 3300 ggagcgcctc tgctgcggcc tgtccatgtt tgaggtcatc ctgacacgga tccggagctt 3360 tctggatgac cccatctggc gcgggcctct gcccagcaat ggggtcatgc atgtggacga 3420 gtgtgtggag tttcacagac tgtggagtgc catgcagttt gtctactgca ttcccgtggg 3480 gacacacgag ttcacagtcg agcagtgctt tggtgatggg ctacactggg ctggctgtat 3540 gatcatcgta cttcttgggc agcagcggcg ttttgctgtg ctggatttct gctaccatct 3600 acttaaagtc cagaaacatg atggcaaaga tgagattatt aaaaatgtgc ctttgaagaa 3660 gatggtggag agaattcgca agttccagat tctcaatgat gagatcatca ccatcctgga 3720 taagtacctg aagtcaggcg acggggaggg cacgccagtg gagcatgtgc gctgcttcca 3780 gccgcccatc caccagtccc tcgccagcag ctgagggcac gcgctgcact ccgtaactca 3840 acatggcatg cctttctctc cgtaaactat ttagtgagat ttttagggac tatttttcag 3900 tatctctgta cctgttaaag ggggtgcttt tcgatctaaa aacttaattt tataaaattg 3960 acttattttt ctagactaaa attgtatatg cttttggtaa ttaggaactc ttgagaatat 4020 tggctgctga ttgttgccat cacgttccta caaaattgtt tttctatggg atgttctggc 4080 agctgtgtca taaaatgctg ctgggttcat tcattcattc cataagaaac ttaataccag 4140 caaatgcatt aaatcccttg ccagttacca ttaactataa ctatttagct tttgtttagg 4200 gatctttctg atggtctttt atgagcaatc ttagttctaa gtcattgttc ccatcccttt 4260 tttgtgtgtt tcagaaaata gtgaacttga ttcccctgct tccactaaat ccagttgtga 4320 caaaatctaa cgtgacatca gatcgaaagg ttatagaaat aaaactaatg agatctaaaa 4380 aaaaaaaaaa aaaa 4394 <210> 43 <211> 1166 <212> DNA <213> Human <400> 43 gcaagaatgg tgcctgtcct gctgtctctg ctgctgcttc tgggtcctgc tgtcccccag 60 gagaaccaag atggtcgtta ctctctgacc tatatctaca ctgggctgtc caagcatgtt 120 gaagacgtcc ccgcgtttca ggcccttggc tcactcaatg acctccagtt ctttagatac 180 aacagtaaag acaggaagtc tcagcccatg ggactctgga gacaggtgga aggaatggag 240 gattggaagc aggacagcca acttcagaag gccagggagg acatctttat ggagaccctg 300 aaagacattg tggagtatta caacgacagt aacgggtctc acgtattgca gggaaggttt 360 ggttgtgaga tcgagaataa cagaagcagc ggagcattct ggaaatatta ctatgatgga 420 aaggactaca ttgaattcaa caaagaaatc ccagcctggg tccccttcga cccagcagcc 480 cagataacca agcagaagtg ggaggcagaa ccagtctacg tgcagcgggc caaggcttac 540 ctggaggagg agtgccctgc gactctgcgg aaatacctga aatacagcaa aaatatcctg 600 gaccggcaag atcctccctc tgtggtggtc accagccacc aggccccagg agaaaagaag 660 aaactgaagt gcctggccta cgacttctac ccagggaaaa ttgatgtgca ctggactcgg 720 gccggcgagg tgcaggagcc tgagttacgg ggagatgttc ttcacaatgg aaatggcact 780 taccagtcct gggtggtggt ggcagtgccc ccgcaggaca cagcccccta ctcctgccac 840 gtgcagcaca gcagcctggc ccagcccctc gtggtgccct gggaggccag ctaggaagca 900 agggttggag gcaatgtggg atctcagacc cagtagctgc ccttcctgcc tgatgtggga 960 gctgaaccac agaaatcaca gtcaatggat ccacaaggcc tgaggagcag tgtgggggga 1020 cagacaggag gtggatttgg agaccgaaga ctgggatgcc tgtcttgagt agacttggac 1080 ccaaaaaatc atctcacctt gagcccaccc ccaccccatt gtctaatctg tagaagctaa 1140 taaataatca tccctccttg cctagc 1166 <210> 44 <211> 5221 <212> DNA <213> Human <400> 44 cggccgcccg ggcaggtttt gtagactttc atagccaaag aaaccggctt cggcttcttt 60 aaaatccccg acgactcacc tgattaacct gctgcagttc tgaccctgcc aagagctgac 120 aatttactgg ttcatcaatg aaacaatatt aaattatgaa gatgtaagga aaaaatccta 180 cgctaacact gtcgcagttt gaaaggcttc tctgcagaat gtcaaacaaa gatcgacaca 240 ttgattccag ctgttcgtcc ttcatcaaga cggaaccttc cagcccagcc tccctgacgg 300 acagcgtcaa ccaccacagc cctggtggct cttcagacgc cagtgggagc tacagttcaa 360 ccatgaatgg ccatcagaac ggacttgact cgccacctct ctacccttct gctcctatcc 420 tgggaggtag tgggcctgtc aggaaactgt atgatgactg ctccagcacc attgttgaag 480 atccccagac caagtgtgaa tacatgctca actcgatgcc caagagactg tgtttagtgt 540 gtggtgacat cgcttctggg taccactatg gggtagcatc atgtgaagcc tgcaaggcat 600 ctttcaagag gaaaatacaa gccaatatag aatacagctg ccctgccacg aatgaatgtg 660 aaatcacaaa gcgcagacgt aaatcctgcc aggcttgccg cttcatgaag tgtttaaaag 720 tgggcatgct gaaagaaggg gtgcgtcttg acagagtacg tggaggtcgg cagaagtaca 780 agcgcaggat agatgcggag aacagcccat acctgaaccc tcagctggtt cagccagcca 840 aaaagccata taacaagatt gtctcacatt tgttggtggc tgaaccggag aagatctatg 900 ccatgcctga ccctactgtc cccgacagtg acatcaaagc cctcactaca ctgtgtgact 960 gtgccgaccg agagttggtg gttatcattg gatgggcgaa gcatatccca ggcttctcca 1020 cgctgtccct ggcggaccag atgagccttc tgcagagtgc ttggatggaa attttgatcc 1080 ttggtttcgt ataccggtct ctttcgtttg aggatgaact tgtctatgca gacgattata 1140 taatggacga agaccagtcc aaattagcag gccttcttga tctaaataat gctatcctgc 1200 agctggtaaa gaaatacaag agcatgaagc tggaaaaaga agaatttgtc accctcaaag 1260 ctatagctct tgctaattca gactccatgc acatagaaga tgttgaagcc gttcagaagc 1320 ttcaggatgt cttacatgaa gcgctgcagg attatgaagc tggccagcac atggaagacc 1380 ctcgtcgagc tggcaagatg ctgatgacac tgccactcct gaggcagacc tctaccaagg 1440 ccgtgcagca tttctacaac atcaaactag aaggcaaagt cccaatgcac aaactttttt 1500 tggaaatgtt ggaggccaag gtctgctaaa agctccctgg gccttccatc cttcattgtt 1560 gaaaagggga aataaaccca agagtgatgt cgaagaaact tagagtttag ttaacaacat 1620 caaaaatcaa cagactgcac tgataattta gcagcaagac tatgaagcag ctttcagatt 1680 cctccatagg ttcctgatga gtttctttct actttctcca tcatcttctt tcctctttct 1740 tcccacattt ctctttctct ttatttttta tccttttctt ctttcacctc ccttatttct 1800 ttgcttcttt cattcctagt tcccattctc ctttattttc ttcccgtctg cctgccttct 1860 ttcttttctt tacctactct cattcctctc ttttctcatc cttccccttt tttctaaatt 1920 tgaaatagct ttagtttaaa aaaaaatcct cccttccccc tttcctttcc ctttctttcc 1980 tttttccctg tccttttccc tttcctttcc tttcctcttg accttctttc catctttctt 2040 tttcttcctt ctgctgctga acttttaaaa gaggtctcta actgaagaga gatggaagcc 2100 agccctgcca aaggatggag atccataata tggatgccag tgaacttatt gtgaaccata 2160 ccgtccccaa tgactaagga atcaaagaga gagaaccaac gttcctaaaa gtacagtgca 2220 catatacaaa ttgactgagt gcagtattag atttcatggg agcagcctct aattagacaa 2280 cttaagcaac gttgcatcgg ctgcttctta tcattgcttt tccatctaga gcagttacag 2340 ccatttgatc ccttaattgt tttttcaagt ctcccaggta tttgttagtt tagctactat 2400 gtaacttttt cagggaatag tttaagcttt attcagtcat gcaatactaa agagaaataa 2460 gaatactgca attttgtgct ggctttgaac aattacgaac aataatgaag gacaaatgaa 2520 tcctgaagga agatttttaa aaatgttttg tttcttctta caaatggaga tttttttgta 2580 ccagctttac cacttttcag ccatttatta atatgggaat ttaacttact caagcaatag 2640 ttgaagggaa ggtgcatatt atcacggttg caatttatgg ttgtgtgccc agtctggtcc 2700 ccaaacatca atttcttaac atgagctcca gtttacctaa atgttcactg acacaaagga 2760 tgagattaca cctacagtga ctctgagtag tcacatatat aagcactgca catgagatat 2820 agatccgtag aattgtcagg agtgcacctc tctacttggg aggtacaatt gccatatgat 2880 ttctagctgc catggtggtt aggaatgtga tacatgcctg tttgcaaagt cacagaccat 2940 tgcctcagaa ggagctgtga gccagtattc atttaagagg caataaggca aatgccagaa 3000 ttaaaaaaaa aaaatcatca aagacagaaa atgcctgacc aaattctaaa acctaatcca 3060 tataagttta ttcatttagg aatgttcgtt taaattaatc tgcagttttt accaagagct 3120 aagccaatat atgtgctttt caaccagtat tgtcacagca tgaaagtcac agtcaggttc 3180 cagactgtta agaggtgtaa tctaatgaag aaatcaatta gatgccccga aatctacagt 3240 cgctgaataa ccaataaaca gtaacctcca tcaaatgcta taccaatgga ccagtgttag 3300 tagctgctcc ctgtattatg tgaacagtct tattctatgt acacagatgt aattaaaatt 3360 gtaatcctaa caaacaaaag aaatgtagtt cagcttttca atgtttcatg tttgctgtgc 3420 ttttctgaat tttatgttgc attcaaagac tgttgtcttg ttcttgtggt gtttggattc 3480 ttgtggtgtg tgcttttaga cacagggtag aattagagac aatattggat gtacaattcc 3540 tcaggagact acagtagtat attctattcc ttaccagtaa taaggttctt cctaataata 3600 attaagagat tgagactcca aacaagtatt cattatgaac agatacacat caaaatcata 3660 ataatatttt cagaacaagg aataatttct ctaatggttt attatagaat accaatgtat 3720 agcttagaaa taaaactttg aatatttcaa gaatatagat aagtctaatt tttaaatgct 3780 gtatatatgg ctttcactca atcatctctc agatgttgtt attaactcgc tctgtgttgt 3840 tgcaaaactt tttggtgcag attcgtttcc aaaactattg ctactttgtg tgctttaaac 3900 aaaatacctt gggttgatga aacatcaacc cagtgctagg aatactgtgt atctatcatt 3960 agctatatgg gactatattg tagattgtgg tttctcagta gagaagtgac tgtagtgtga 4020 ttcttgataa atcatcatta gcaattcatt cagatggtca ataacttgaa atttatagct 4080 gtgataggag ttcagaaatt ggcacatccc tttaaaaata acaacagaaa atacaactcc 4140 tgggaaaaaa aggtgctgat tctataagat tatttatata tgtgagtgtt taaaaagatt 4200 attttccaga aagtttgtgc agggtttaag ttgctactat tcaactacac tatatataaa 4260 taagatatat acaatatata cattgttttc actgtatcac attaaagtac ttgggcttca 4320 gaagtaagaa gccaaccaac tgaaaacctg agatggagat atgttcaaag aatgagatac 4380 aattttttag ttttcagttt aagtaactct cagcattaca aaagagtaag tatctcacaa 4440 ataggaaata aaactaaaac gtagatttaa aaaagaactg cacgggcttt agggtaaatg 4500 ctcatcttaa acctcactag agggaagtct tctcaagttt caagcaagac catttactta 4560 atgtgaagtt ttggaaagtt ataaaggtgt atgttttagc catatgatcc taaatttaat 4620 tttgctcttt taggttcgtt cttatttaaa gcaatatgat tgtgtgactc cttgtagtta 4680 cacttgtgtt tcaatcagat cagattgttg tatttattcc actattttgc atttaaatga 4740 taacataaca gatataaaaa atttaaaact gctatttttc ttatagaaga gaaaatgggt 4800 gttggtgatt gtattttaat tatttaagcg tctctgttta cctgcctagg aaaacatttt 4860 atggcagtct tatgtgcaaa gatcgtaaaa ggacaaaaaa tttaaactgc ttataataat 4920 ccaggagttg cattatagcc agtagtaaaa aaaataataa taataataat aaaaccatgt 4980 ctatagctgt agatgggctt cacatctgta aagcaatcaa ttgtatattt ttgtgatgtg 5040 taccatactg tgtgctccag caaatgtcca tttgtgtaaa tgtatttatt ttatattgta 5100 tatattgtta aatgcaaaaa ggagatatga ttctgtaact ccaatcagtt cagatgtgta 5160 acccaaatat tatgcctttc aggatgatgg tagagcaata ttaaacaagc ttccactttt 5220 g 5221 <210> 45 <211> 1174 <212> DNA <213> Human <400> 45 ggcacgaggg ggccggagga gggacgcgcc ggagcgggac cgacgggacc gagcgagcga 60 ccgacgcgcc acccgccgac gcctcagccg cttggggccc gcacggaccc tctacttcag 120 tgtagaatga gccaaggaga ctcaaaccca gcagctattc cgcatgcagc agaagatatt 180 caaggagatg accgatggat gtctcagcac aacagatttg ttttggactg taaagacaaa 240 gagcctgatg tactgttcgt gggagactcc atggtgcagt taatgcagca atatgagata 300 tggcgagagc ttttttcccc acttcatgca ctgaattttg gaattggggg agatacaaca 360 agacatgttt tgtggagact aaagaatgga gaactggaga atattaagcc taaggtcatt 420 gttgtctggg taggaacaaa taaccacgaa aatacagcag aagaagtagc aggtgggatc 480 gaggccattg tacaacttat caacacaagg cagccacagg ccaaaatcat tgtattgggt 540 ttgttacctc gaggtgagaa acccaatcct ttgaggcaaa agaacgccaa ggtgaaccaa 600 ctcctcaagg tttcgctgcc gaagcttgcc aacgtgcagc tcctggatac cgacgggggt 660 tttgtgcact cggacggtgc catctcctgc cacgacatgt ttgattttct gcatctgaca 720 ggagggggct atgcaaagat ctgcaaaccc ctgcatgaac tgatcatgca gttgttggag 780 gaaacacctg aggagaaaca aaccaccatt gcctgactgg ctcttatcag tgttaatagc 840 atctcagctt cctcagatca gttctatcac tggcactaca gaatccttct ctttcttaag 900 gcactttgca ttgtagaatg ttcctggatg ttcatatcta gtgtttgaag gggaggaggg 960 atttaaactg gtcctgtaca tagaaggttt gtttgacaga ggagaaaaat tagccaagga 1020 agattgttgt ttaaattcat ttgaaaccag aaggggactt tttagttgta tgtgtaacac 1080 attcattgaa ttattatcac tgttttcttg ggacaacatc aagcctaaat actgaacaat 1140 atgaagatta aaaaaaaaaa aaaaaaaaaa aaaa 1174 <210> 46 <211> 1619 <212> DNA <213> Human <400> 46 ggggatatgg cggggccttt gtctctcgct gtcgccggag tcccaggtct gtcttcactg 60 ctctgtgtcc tctgctccta gaggcccagc ctctgtggcg ctgttaccag cagtattgga 120 gatccacagc taagatgcca ggacccccta gaagcctaga aatgggactg ttgacattta 180 gggatgtggc catagaattc tctctggagg agtggcaaca cctggacatt gcacagcaga 240 atttatatag aaatgtgatg ttagagaact acagaaacct ggccttcctg ggtattgctg 300 tctctaagcc agacctgatc acctgtctgg aacaagggaa agagccctgg aatatgaagc 360 gacatgagat ggtggatgaa cccccaggta tgtgtcctca ttttgctcaa gacctttggc 420 cagagcaggg catggaagat tcttttcaaa aagcaatact gagaagatat ggaaaatatg 480 gacatgagaa tttacagtta agaaaaggct gtaaaagtgt ggatgagtat aaggtgaaca 540 aagaaggtta taatggactt aaccagtgtt tcacaactgc ccagagcaaa gtatttcaat 600 gtgataaata tttgaaagtc ttctataaat ttttaaattc aaacagacct aagataagac 660 atactgaaaa gaaatctttc aaatgtaaaa aacgtgtcaa attattttgc atgctttcac 720 ataaaaccca acacaaaagc atttatcata gagagaagtc ctacaaatgt aaagaatgtg 780 gaaaaacctt taattggtcc tcaaccctta ctaatcatag gaaaatttat actgaagaga 840 aaccttacaa atgtgaagaa tataacaaat ctcctaagca actctcaacc cttactacac 900 atgaaataat tcatgctgga gagaaactct acaaatgtga agaatgtggc aaagctttta 960 atcggtcctc aacttttact aaacataagg taattcatac tggagtaaaa ccctacaaat 1020 gtgaagaatg tggcaaagca tttttctggt cctcaaccct aactaaacat aagagaattc 1080 atactggaga gcaaccctac aaatgggaaa aatttggcaa agcctttaat cggtcctcgc 1140 acctcaccac agataagata actcatactg gagagaaatc ttacaagtat gaataatgtg 1200 ccaaagccta agaaaaccct caattcttaa tagatataag attattccta ctggagagaa 1260 actacaaacc tgagagaggc gctaatgctt ttgacagtac ctaaaacttt aaagaaaatc 1320 attctgctga aaaatcctag aaatgtgaag aatgtgaaaa agcctttaaa tgattgtcac 1380 acttgattgt aggtaagata attcatactg gagaaaacta ccagtgtgaa caacgtggcc 1440 aagcttcgac aatgctcaca ccctattgca caggaaagca tttatacttg agaagaaatg 1500 tacaaatatt ggcaaagtaa aaaatccatt aacacctgct cacatcttac tcaaaattgt 1560 agagttcata gtaaataaaa gcattaaaat tcaaaaaaaa aaaaaaaaaa aaaaaaaaa 1619 <210> 47 <211> 534 <212> DNA <213> Human <400> 47 tttttacaac atatatcttt aattaaattt atattggtgg gtttaaaaaa cattaagtca 60 ggagatgata gctagggaaa taaggtatcc tgtgagtatt tataacaaaa tatttaaaat 120 ttaaaaagaa taagaaacat caattggctt tttgtaactt aaaagagact aaccaagtgt 180 tgtttcccag ttctgtacaa gcagaggcca caggaggatt cttacataag aagcacaggg 240 aaaagaattg ttaattctgc gtgtgtgttt ttgtttctca gaattgtttg gaagaacttt 300 gtccagtcag aaatgagtaa aaacaagatg taagaaacat taaaacaggg ggcatatggt 360 cttaagagat aatcttggag aatatagcaa aagacaaatt gctccattag atattataat 420 ttggtatgta acatgaacat ttaaaattct gattaaagtg actaaaaggg tttgtttttt 480 aaaaaaaatc aaaacagaac ttacgggata aaactcagaa taaatttact ctca 534 <210> 48 <211> 4763 <212> DNA <213> Human <220> <221> misc_feature <222> (3847)..(3847) <223> any kind of base <400> 48 cccctcaccc cactcaactg ccccgggccc ccgcgcgcgc ggccgcccct ccactcaccc 60 tgtgtcggcc ccgctcccct ctcccccacc aggcgagcag gcgagcgggc agagcccgcg 120 gcggaggtcg gcgcggctcc ggggttcatg gtgacgaggc ggcggccgct cgagcccagc 180 ggcggcgggc ggcgggagct ggggcgcggg cccgggccgc ctctcccaga gcgcggggcc 240 gggcggcggg cgcgcccagg cagcggctgc gagcgccccc ccgcgccgcg cccccgcgcc 300 ccccgcgccg cgcccccgcg cgcttggctt gcggggggcc gggcctgcgg gcggccgccg 360 cgccgcgcac ccatggacgg cccggccatc atcacccagg tgaccaaccc caaggaggac 420 gagggccggt tgccgggcgc gggcgagaaa gcctcccagt gcaacgtcag cttaaagaag 480 cagaggagcc gcagcatcct tagctccttc ttctgctgct tccgtgatta caatgtggag 540 gcccctccac ccagcagccc cagtgtgctt ccgccactgg tggaggagaa tggtgggctt 600 cagaagccac cagctaagta ccttcttcca gaggtgacgg tgcttgacta tggaaagaaa 660 tgtgtggtca ttgatttaga tgaaacattg gtgcacagtt cgtttaagcc tattagtaat 720 gctgatttta ttgttccggt tgaaatcgat ggaactatac atcaggtgta tgtgctgaag 780 cggccacatg tggacgagtt cctccagagg atggggcagc tttttgaatg tgtgctcttt 840 actgccagct tggccaagta tgcagaccct gtggctgacc tcctagaccg ctggggtgtg 900 ttccgggccc ggctcttcag agaatcatgt gtttttcatc gtgggaacta cgtgaaggac 960 ctgagtcgcc ttgggcggga gctgagcaaa gtgatcattg ttgacaattc ccctgcctca 1020 tacatcttcc atcctgagaa tgcagtgcct gtgcagtcct ggttcgatga catgacggac 1080 acggagctgc tggacctcat ccccttcttt gagggcctga gccgggagga cgacgtgtac 1140 agcatgctgc acagactctg caataggtag ccctggcctc tgcctgcctc ccgcctgtgc 1200 actctggaac ctctggcctc aggggacctg cctgtcctca gctccctggg agctgaaagt 1260 gaggatactc cgtgctccag gccacagggt gaatgtggcc atgcctacct gttttgtttt 1320 tttaagaaca gaaacaacta ttttaaaaga actcttttaa gaaatttcat aaagggacat 1380 gcattttact gggtttgctt ttcttaaaac ataccaaaaa agaaaaaaat agaaaaaaaa 1440 aaaaaaaaag ctgatctcta tcagactctt caactgtcct ccctccaagc agaccacctg 1500 tccccttcta tcccagctca gagcagctga cccaactcag aatctctttc ctacaggatg 1560 aaagtgcctt ttgaatgtta tttttaagcc gagagttaat ttttctacac aacatatttc 1620 cagacatctt ttagtctttt attgtcttag atactataag aagatgaaca tgacaatttt 1680 ctagaacctg gtagcgtgtg tgtgtggttg gcggggggtg ctgagggagg ggagtgagtc 1740 acaggagcct gtcccccaac aggtgtgact gctctgacaa cctgtggcat gctgcagggt 1800 caggctcctg ataggaggat ttcatgacta tgtcattgtc tccactcatt tttgacccag 1860 tttggaatgt atctgcaatt gtgtggctca acactttagg aaacatagat tattttatat 1920 tattatttct gatggtgaca agtttgtctt gaggtcacat tttctccttg aaaagtgaca 1980 tcctgtcact tctgctctca cactactgcc atacatttgt gtttttttgt tgttattgtt 2040 tgggtagagc agttacaaga aaccctaaaa cccttggata taaaagaaat ctgtttattg 2100 atttttaaat ctttcctttc caaaagctgg atacacatgg agctgtttgg gaattttcct 2160 tgctgctacc gcgctgccac caaatggaat tgaccagcgg ctgttacact gttctttgcc 2220 actgtgccta tgctcagaat atgctcactg ctaagctaca aactcggaca gggtcagaaa 2280 cagaggtgtc ccatcccatt gcagcctcca ccacctgtaa ccccttcctg gcattggcca 2340 ctgaagggta caaaggcaaa aggaccacag caccacttag gtgtagcatg gattttaaac 2400 tgcagtcagt atcagatcct gtttgataaa taagctgact gttctctctt gagaacctgt 2460 ggcctcaacc agccaccaag ctgatgtggc ccaagctcca tctcttggtc ttctcctttg 2520 aagcacagcc tatttctgag ccaagggttg gggaagcctg tctagatgtg ggactcattg 2580 ccccaaacca gggagaggaa gagctcccac agggagagcc caggctctct ttgcagcctt 2640 tcccagtttg gtgtttaaag cagtgccatg ttccttgttt gacaacaaga cagtctgtaa 2700 agtattgctc ttaaaaacaa ttaaaaagaa ccctttcata ttggcaccat tgccttagtc 2760 ctctgtgggt tggtcttcag ccagcattct ggtgggagtg actggcatta acaagactgg 2820 aaatcggggg tcaaagtaaa atatctttgt tttgctttca ttcacaaagt aatgaagcca 2880 gctgccaatt acatcctccc aacagcactt tggtctgtga ctgctgtgtg atattcagaa 2940 gggaagtagt attcaggggg taaacaggtc tcccagcatt ctgagtgttc caaaccagta 3000 atccacatgc caattcaaat agaacagccc cttgctagat attaccacag ataatgacag 3060 tacatggtag aactgcccat gccacaaata tttatttgga aaagtagtca ttaaatgaac 3120 ccactgcctt aaatgtcttg aatgttgcag tcaagtgtct gtcatgtgtt gatatccaca 3180 cagaattagg ccctaatgag agccttagac cctcaaccat gcccccttcg ttggcatcac 3240 agggccttat ttggaagagc ggggcaaaga ggatggaaat cataaaatat ttcatgggaa 3300 tcgaacctag ggatagtgct ccacttctga cgatggagtg aagacacttg gcagacttga 3360 gccagacact tcacctagta gttcctgaaa ctgtgagcac cactgcacta agccagtgcg 3420 gagctgttag ggacgggccc agctcctgca cacggacaca gaatgtctgg agagggcagc 3480 aggcctctga gggttctgga atctgtgcca ccttatttga ccacactcca aaattctgtt 3540 tttattttaa cccttgaatc tgctttatgt acataatcaa aatatctata tctatatcta 3600 tatctatatc tatatatttt taatcatcta catgtaaatg aagcaataga attctaacat 3660 aaggccaaga aatgagacga atgtttgggg tttatgtttt ttaaggtaaa tacgggtatt 3720 gtttttaatt attaccatgt attaaattgt gggctttgaa acctaatgaa acctgttagc 3780 cacttctctg tgccatatac ttcccatgtt accaaaatac gcccaactct ttagccaaaa 3840 gagaacnctg acctcctgag tttccatgct cctttctgtc aggtttaaat gtagtcttct 3900 ggagaagtat ttttgacatt gagctctggg acaggacacc ttgggtttgt ggactgcagc 3960 ccactatgat gttattactt ctctggccag gcctccagtg gaagtgcaca ggcactccca 4020 atgttgttaa tgctctgtct tccatttgtt ctggaatcct acgtgttggt ctgtggttcc 4080 atgcattagc tgtttgtaaa taatgcattt gcatactgaa aaaggaatgc cacctgccac 4140 agttgatggt gagaagctcc tttgacgtgg tgcaattttg atgagatgtc tctggggaca 4200 cgaggatgcc ctaatgatgc tgacttgtca tggttgcagc atttgaactt ttggtgttaa 4260 aaaaaaaaac ctgtaagtct gtaacctggc aacattttac aaccctgtat ttttaaagat 4320 ggctttctaa taaaaaatcc agaaccacac agccctatgg tcaaacaatc ctacgtttgt 4380 gcctctgctt ttaaaggtgc tgtgctggac agttggcatg ccagggttcg agaagagtga 4440 atggcttgac gtccttgcag ttaactgtgc aaaattggct ggctgcctct gttcctactg 4500 tactgtaact ttgatcatgt ctgttcctat tccattctcc caggagcttc tctgcagact 4560 gacacaccct cccccacccc gggtagtgga gatgctggtg tctgggtagt catggatttc 4620 tgctgacatt tgaatgtgat aaacaatcca gcattactta ggaaatgcta catgcggaat 4680 gtgcacgttt ccaggggcga gtattgtcaa tcaaaaggtt tgcaatgatt tccttcctgc 4740 caaaaataaa catgtgaaac tgc 4763 <210> 49 <211> 10300 <212> DNA <213> Human <400> 49 aactgctagt ggctgagtcc ctggcggggc gcggcggtgg aaggtgtcgc gtacgggctt 60 cccgagctga cgtggcttga attgggaggg gggcagctgg agcctcaggc ggcagcgctt 120 ctagaaatgc tgagccgatt atcaggatta gcaaatgttg ttttgcatga attatcagga 180 gatgatgaca ctgatcagaa tatgagggct cccctagacc ctgaattaca ccaagaatct 240 gacatggaat ttaataatac tacacaagaa gatgttcagg agcgcctggc ttatgcagag 300 caattggtgg tggagctaaa agatattatt agacagaagg atgttcaact gcagcagaaa 360 gatgaagctc tacaggaaga gagaaaagct gctgataaca aaattaaaaa actaaaactt 420 catgcgaagg ccaaattaac ttctttgaat aaatacatag aagaaatgaa agcacaagga 480 gggactgttc tgcctacaga acctcagtca gaggagcaac tttccaagca tgacaagagt 540 tctacagagg aagagatgga aatagaaaag ataaaacata agctccagga gaaggaggaa 600 ctaatcagca ctttgcaagc ccagcttact caggcacagg cagaacaacc tgcacagagt 660 tctacagaga tggaagaatt tgtaatgatg aagcaacagc tccaggagaa ggaagaattc 720 attagcactt tacaagccca gctcagccag acacaggcag agcaagctgc acagcaggtg 780 gtccgagaga aagatgcccg ctttgaaaca caagttcgtc ttcatgaaga tgagcttctt 840 cagttagtaa cccaggcaga tgtggaaaca gagatgcaac agaaattgag ggtgctgcaa 900 aggaagcttg aggaacacga agaatccttg gtgggccgtg ctcaggtcgt tgacttgctg 960 caacaggagc tgactgctgc tgagcagaga aaccagattc tctctcagca gttacagcag 1020 atggaagctg agcataatac tttgaggaac actgtggaaa cagaaagaga ggagtccaag 1080 attctactgg aaaagatgga acttgaagtg gcagagagaa aattatcctt ccataatctg 1140 caggaagaaa tgcatcatct tttagaacag tttgagcaag caggccaagc ccaggctgaa 1200 ctagagtctc ggtatagtgc tttggagcag aagcacaaag cagaaatgga agagaagacc 1260 tctcatattt tgagtcttca aaagactgga caagagctgc agtctgcctg tgatgctcta 1320 aaggatcaaa attcaaagct tctccaagat aagaatgaac aggcagttca gtcagcccag 1380 accattcagc aactggaaga tcagctccag caaaaatcca aagaaattag ccaatttcta 1440 aatagactgc ccttgcaaca acatgaaaca gcatctcaga cttctttccc agatgtttat 1500 aatgagggca cacaggcagt cactgaggag aatattgctt ctttgcagaa gagagtggta 1560 gaactagaga atgaaaaggg agccttgctc cttagttcta tagagctgga ggagctgaaa 1620 gctgagaatg aaaaactgtc ttctcagatt actctcctag aggctcagaa tagaactggg 1680 gaggcagaca gagaagtcag tgagatcagc attgttgata ttgccaacaa gaggagctct 1740 tctgctgagg aaagtggaca agatgttcta gaaaacacat tttctcagaa acataaagaa 1800 ttatcagttt tattgttgga aatgaaagaa gctcaagagg aaattgcatt tcttaaatta 1860 cagctccagg gaaaaagggc tgaggaagca gatcatgagg tccttgacca gaaagaaatg 1920 aaacagatgg agggtgaggg aatagctcca attaaaatga aagtatttct tgaagataca 1980 gggcaagatt ttcccttaat gccaaatgaa gagagcagtc ttccagcagt tgaaaaagaa 2040 caggcgagca ctgaacatca aagtagaaca tctgaggaaa tatctttaaa tgatgctgga 2100 gtagaattga aatcaacaaa gcaggatggt gataaatccc tttctgctgt accagatatt 2160 ggtcagtgtc atcaggatga gttggaaagg ttaaaaagtc aaattttgga gctcgagcta 2220 aactttcata aagcacaaga aatctatgag aaaaatttag atgagaaagc taaggaaatt 2280 agcaacctaa accagttgat tgaggagttt aagaaaaatg ctgacaacaa cagcagtgca 2340 ttcactgctt tgtctgaaga aagagaccag cttctctctc aggtgaagga acttagcatg 2400 gtaacagaat tgagggctca ggtaaagcaa ctggaaatga accttgcaga agcagaaagg 2460 caaagaagac ttgattatga aagccaaact gcccatgaca acctgctcac tgaacagatc 2520 catagtctca gcatagaagc caaatctaaa gatgtgaaaa ttgaagtttt acagaatgaa 2580 ctggatgatg tgcagcttca gttttctgag cagagtaccc tgataagaag cctgcaaagc 2640 cagctgcaaa ataaggaaag tgaagtgctt gagggggcag aacgtgtaag gcatatctca 2700 agtaaagtgg aagaactgtc ccaggctctt tcacagaagg aacttgaaat aacaaaaatg 2760 gatcagctct tactagagaa aaagagagat gtggaaaccc tccaacaaac catcgaggag 2820 aaggatcaac aagtgacaga aatcagcttt agtatgactg agaaaatggt tcagcttaat 2880 gaagagaagt tttctcttgg ggttgaaatt aagactctta aagaacagct aaatttatta 2940 tccagagctg aggaagcaaa aaaagagcag gtggaagaag ataatgaagt ttcttctggc 3000 cttaaacaaa attatgatga gatgagccca gcaggacaaa taagtaagga agaacttcag 3060 catgaatttg accttctgaa gaaagaaaat gagcagagaa agagaaagct ccaggcagct 3120 cttattaaca gaaaggagct tctgcaaaga gtcagtagat tggaagaaga attagccaac 3180 ttgaaagatg aatctaagaa agaaatccca ctcagtgaga ctgagagggg agaagtggaa 3240 gaagataaag aaaacaaaga atactcagaa aaatgtgtga cttctaagtg ccaagaaata 3300 gaaatttatt taaaacagac aatatctgag aaagaagtgg aactacagca tataaggaag 3360 gatttggaag aaaagctggc agctgaagag caattccagg ctctggtcaa acagatgaat 3420 cagaccttgc aagataaaac aaaccaaata gatttgctcc aagcagaaat cagtgaaaac 3480 caagcaatta tccagaagtt aatcacaagt aacacggatg caagtgatgg ggactccgta 3540 gcacttgtaa aggaaacagt ggtgataagt ccaccttgta caggtagtag tgaacactgg 3600 aaaccagaac tagaagaaaa gatactggcc cttgaaaaag aaaaggagca acttcaaaag 3660 aagctacagg aagccttaac ctcccgcaag gcaattctta aaaaggcaca ggagaaagaa 3720 agacatctca gggaggagct aaagcaacag aaagatgact ataatcgctt gcaagaacag 3780 tttgatgagc aaagcaagga aaatgagaat attggagacc agctaaggca actccagatt 3840 caagtaaggg aatccataga cggaaaactc ccaagcacag accagcagga atcgtgttct 3900 tccactccag gtttagaaga acctttattc aaagccacag aacagcatca cactcaacct 3960 gttttagagt ccaacttgtg cccagactgg ccttctcatt ctgaagatgc gagtgctctg 4020 cagggcggaa cttctgttgc ccagattaag gcccagctga aggaaataga ggctgagaaa 4080 gtagagttag aattgaaagt tagttctaca acaagtgagc ttactaaaaa atcagaagag 4140 gtatttcagt tacaagagca gataaataaa cagggtttag aaatcgagag tctaaagaca 4200 gtatcccatg aagctgaagt ccatgccgaa agcctgcagc agaaattgga aagcagccaa 4260 ctacaaattg ctggcctaga acatctaaga gaattgcaac ctaaactgga tgaactgcaa 4320 aaactcataa gcaaaaagga agaagacgtt agctaccttt ctggacaact tagtgagaaa 4380 gaagcagctc tcactaaaat acagacagag ataatagaac aagaagattt aattaaggct 4440 ctgcatacac agctagaaat gcaagccaaa gagcatgatg agaggataaa gcagctacag 4500 gtggaacttt gtgaaatgaa gcaaaaacca gaagagattg gagaagaaag tagagcaaag 4560 caacaaatac aaaggaaact gcaagctgcc cttatttccc gaaaagaagc actaaaagaa 4620 aacaaaagtc tccaagagga attgtctttg gccagaggta ccattgaacg tctcaccaag 4680 tctctggcag atgtggaaag ccaagtttct gctcaaaata aagaaaaaga tacggtctta 4740 ggaaggttag ctcttcttca agaagaaaga gacaaactca ttacagaaat ggacaggtct 4800 ttattggaaa atcagagtct cagcagctcc tgtgaaagtc taaaactagc tctagagggt 4860 cttactgaag acaaggaaaa gttagtgaag gaaattgaat ctttgaaatc ttctaagatt 4920 gcagaaagta ctgagtggca agagaaacac aaggagctac aaaaagagta tgaaattctt 4980 ctgcagtcct atgagaatgt tagtaatgaa gcagaaagga ttcagcatgt ggtggaagct 5040 gtgaggcaag agaaacaaga actgtatggc aagttaagaa gcacagaggc aaacaagaag 5100 gagacagaaa agcagttgca ggaagctgag caagaaatgg aggaaatgaa agaaaagatg 5160 agaaagtttg ctaaatctaa acagcagaaa atcctagagc tggaagaaga gaatgaccgg 5220 cttagggcag aggtgcaccc tgcaggagat acagctaaag agtgtatgga aacacttctt 5280 tcttccaatg ccagcatgaa ggaagaactt gaaagggtca aaatggagta tgaaaccctt 5340 tctaagaagt ttcagtcttt aatgtctgag aaagactctc taagtgaaga ggttcaagat 5400 ttaaagcatc agatagaaga taatgtatct aaacaagcta acctagaggc caccgagaaa 5460 catgataacc aaacgaatgt cactgaagag ggaacacagt ctataccagg tgagactgaa 5520 gagcaagact ctctgagtat gagcacaaga cctacatgtt cagaatcggt tccatcagcg 5580 aagagtgcca accctgctgt aagtaaggat ttcagctcac atgatgaaat taataactac 5640 ctacagcaga ttgatcagct caaagaaaga attgctggat tagaggagga gaagcagaaa 5700 aacaaggaat ttagccagac tttagaaaat gagaaaaata ccttactgag tcagatatca 5760 acaaaggatg gtgaactaaa aatgcttcag gaggaagtaa ccaaaatgaa cctgttaaat 5820 cagcaaatcc aagaagaact ctccagagtt accaaactaa aggagacagc agaagaagag 5880 aaagatgatt tggaagagag gcttatgaat caattagcag aacttaatgg aagcattggg 5940 aattactgtc aggatgttac agatgcccaa ataaaaaatg agctattgga atctgaaatg 6000 aagaacctta aaaagtgtgt gagtgaattg gaagaagaaa agcagcagtt agtcaaggaa 6060 aaaactaagg tggaatcaga aatacgaaag gaatatttgg agaaaataca aggtgctcag 6120 aaagaacccg gaaataaaag ccatgcaaag gaacttcagg aactgttaaa agaaaaacaa 6180 caagaagtaa agcagctaca gaaggactgc atcaggtatc aagagaaaat tagtgctctg 6240 gagagaactg ttaaagctct agaatttgtt caaactgaat ctcaaaaaga tttggaaata 6300 accaaagaaa atctggctca agcagttgaa caccgcaaaa aggcacaagc agaattagct 6360 agcttcaaag tcctgctaga tgacactcaa agtgaagcag caagggtcct agcagacaat 6420 ctcaagttga aaaaggaact tcagtcaaat aaagaatcag ttaaaagcca gatgaaacaa 6480 aaggatgaag atcttgagcg aagactggaa caggcagaag agaagcacct gaaagagaag 6540 aagaatatgc aagagaaact ggatgctttg cgcagagaaa aagtccactt ggaagagaca 6600 attggagaga ttcaggttac tttgaacaag aaagacaagg aagttcagca acttcaggaa 6660 aacttggaca gtactgtgac ccagcttgca gcctttacta agagcatgtc ttccctccag 6720 gatgatcgtg acagggtgat agatgaagct aagaaatggg agaggaagtt tagtgatgcg 6780 attcaaagca aagaagaaga aattagactc aaagaagata attgcagtgt tctaaaggat 6840 caacttagac agatgtccat ccatatggaa gaattaaaga ttaacatttc caggcttgaa 6900 catgacaagc agatttggga gtccaaggcc cagacagagg tccagcttca gcagaaggtc 6960 tgtgatactc tacaggggga aaacaaagaa cttttgtccc agctagaaga gacacgccac 7020 ctataccaca gttctcagaa tgaattagct aagttggaat cagaacttaa gagtctcaaa 7080 gaccagttga ctgatttaag taactcttta gaaaaatgta aggaacaaaa aggaaacttg 7140 gaagggatca taaggcagca agaggctgat attcaaaatt ctaagttcag ttatgaacaa 7200 ctggagactg atcttcaggc ctccagagaa ctgaccagta ggctgcatga agaaataaat 7260 atgaaagagc aaaagattat aagcctgctt tctggcaagg aagaggcaat ccaagtagct 7320 attgctgaac tgcgtcagca acatgataaa gaaattaaag agctggaaaa cctgctgtcc 7380 caggaggaag aggagaatat tgttttagaa gaggagaaca aaaaggctgt tgataaaacc 7440 aatcagctta tggaaacact gaaaaccatc aaaaaggaaa acattcagca aaaggcacag 7500 ttggattcct ttgttaaatc catgtcttct ctccaaaatg atcgagaccg catagtgggt 7560 gactatcaac agctggaaga gcgacatctc tctataatct tggaaaaaga ccaactcatc 7620 caagaggctg ctgcagagaa taataagctt aaagaagaaa tacgaggctt gagaagtcat 7680 atggatgatc tcaattctga gaatgccaag ctagatgcag aactgatcca atatagagaa 7740 gacctgaacc aagtgataac aataaaggac agccaacaaa agcagcttct tgaagttcaa 7800 cttcagcaaa ataaggagct ggaaaataaa tatgctaaat tagaagaaaa gctgaaggaa 7860 tctgaggaag caaatgagga tctgcggagg tcctttaatg ccctacaaga agagaaacaa 7920 gatttatcta aagagattga gagtttgaaa gtatctatat cccagctaac aagacaagta 7980 acagccttgc aagaagaagg tactttagga ctctatcatg cccagttaaa agtaaaagaa 8040 gaagaggtac acaggttaag tgctttgttt tcctcctctc aaaagagaat tgcagaactg 8100 gaagaagaat tggtttgtgt tcaaaaggaa gctgccaaga aggtaggtga aattgaagat 8160 aaactgaaga aagaattaaa gcatcttcat catgatgcag ggataatgag aaatgaaact 8220 gaaacagcag aagagagagt ggcagagcta gcaagagatt tggtggagat ggaacagaaa 8280 ttactcatgg tcaccaaaga aaataaaggt ctcacagcac aaattcagtc ttttggaagg 8340 tctatgagtt ccttgcaaaa tagtagagat catgccaatg aggaacttga tgaactgaaa 8400 aggaaatatg atgccagtct gaaggaattg gcacagttga aagaacaggg actcttaaac 8460 agagagagag atgctcttct ttctgaaacc gccttttcaa tgaactccac tgaggagaat 8520 agcttgtctc accttgagaa acttaaccaa cagctcctat ccaaagatga gcaattgctt 8580 cacttgtcct cacaactaga agattcttat aaccaagtgc agtccttttc caaggctatg 8640 gccagtctgc agaatgagag agatcacctg tggaatgagc tggagaaatt tcgaaagtca 8700 gaggaaggga agcagaggtc tgcagctcag ccttccacca gcccagctga agtacagagt 8760 ttaaaaaaag ctatgtcttc actccaaaat gacagagaca gactactgaa ggaattgaag 8820 aatctgcagc agcaatactt acagattaat caagagatca ctgagttaca tccactgaag 8880 gctcaacttc aggagtatca agataagaca aaagcatttc agattatgca agaagagctc 8940 aggcaggaaa acctctcctg gcagcatgag ctgcatcagc tcaggatgga gaagagttcc 9000 tgggaaatac atgagaggag aatgaaggaa cagtacctta tggctatctc agataaagat 9060 cagcagctca gtcatctgca gaatcttata agggaattga ggtcttcttc ctcccagact 9120 cagcctctca aagtgcaata ccaaagacag gcatccccag agacatcagc ttccccagat 9180 gggtcacaaa atctggttta tgagacagaa cttctcagga cccagctcaa tgacagctta 9240 aaggaaattc accaaaagga gttaagaatt cagcaactga acagcaactt ctctcagcta 9300 ctggaagaga aaaacaccct ttccattcag ctctgcgata ccagtcagag tcttcgtgag 9360 aaccagcagc actatggtga ccttttaaat cactgtgcag tcttggagaa gcaggttcaa 9420 gagctgcagg cggggccact aaatatagat gttgctccag gagctcccca ggaaaagaat 9480 ggagttcaca gaaagagtga ccctgaggaa ctaagggaac cgcagcaaag cttttctgaa 9540 gctcagcagc agctatgcaa caccagacag gaagtgaatg aattaaggaa gctgctggaa 9600 gaagaacgag accaaagagt ggctgctgag aatgctctct ctgtggccga ggagcagatc 9660 agacggttag agcacagtga atgggactct tcccggactc ctatcattgg ctcctgtggc 9720 actcaggagc aggcactgtt aatagatctt acaagcaaca gttgtcgaag gacccggagt 9780 ggcgttggat ggaagcgagt cctgcgttca ctctgtcatt cacggacccg agtgccactt 9840 ctagcagcca tctactttct aatgattcat gtcctgctca ttctgtgttt tacgggccat 9900 ctatagactt agttgttact ctttggacca ctcccttcaa aacttggaat tctctcacct 9960 ctaacatcag aacatcaatt ccagtggaac agtcttccca tttacaggtc ttctctccaa 10020 ctcttcacgg aaagtgcctg caaaaacaga ggtggatacg aggacaggtt ggagctgcag 10080 ggactggcga gtctgctttc ttctactgcc ctgagcctga acgcttctgc ttaatctgag 10140 aatcacattt ggtttgttga gcctaatatt tgttgagatt ttgcaggacc ctgatctttt 10200 gtggtcctgt aaaagatact gaggaatgtc tttcagccaa gccaagagga tggtttcaat 10260 aaacctaata atctgaagtt cagctttttt tttttttttt 10300 <210> 50 <211> 2357 <212> DNA <213> Human <400> 50 gaggagacgc gctttgtgct gggcgccggc cgcgccagcc acggcctgcg gcgcccgcgg 60 caccatgatc tccaccaagg agaagaacaa gatcccgaag gacagcatga cgcttctgcc 120 ctgcttctac ttcgtggagc tgcccatagt ggcttcttcc atcgtatcct tgtacttcct 180 ggagctgacc gacctcttca agccggccaa ggtgggcttc cagtgctatg accgcactct 240 ctccatgccc tacgtggaga ccaacgagga gctcatcccg ctgctgatgc tgctcagctt 300 ggccttcgcg gcccctgccg cctcgatcat ggtggccgag ggcatgttgt actgtctgca 360 gtcccggctg tggggccgtg ccggggggcc cgccggggcg gagggcagca tcaacgccgg 420 cggctgcaac ttcaactcct tcctgcggcg tacggtgcgg tttgtgggtg tccacgtgtt 480 cggcctgtgt gccacagccc tggtgacgga cgtgatccag ctggccacgg gttaccacac 540 tcccttcttc ctcaccgtct gcaagcccaa ctacactctc ctgggcacgt cctgcgaggt 600 caacccctac atcacgcagg acatctgctc cggccacgac atccacgcca tcctgtctgc 660 acggaagacc ttcccgtccc agcacgccac gctgtcagcc ttcgccgcgg tctatgtgtc 720 ggtgagtccg gcacctcact gcccttccca ggccctcttg ctgacccgtg gggagccctc 780 cctgacccca acccccatgc cccagatgta cttcaactcg gtcatctcgg acaccaccaa 840 gctgctgaag cccatcctgg tcttcgcctt tgccatcgcc gcgggcgtat gcgggctcac 900 gcagatcacg cagtaccgca gccaccctgt ggacgtgtat gccggcttcc tcatcggggc 960 gggcatcgct gcctacctgg cctgccacgc ggtgggcaac ttccaggccc cacctgcaga 1020 gaagcccgcg gccccggccc ccgccaagga cgcgctgcgg gccctgacgc agcggggcca 1080 cgactcggtt tatcagcaga ataagtcggt gagcaccgac gagctggggc ccccagggcg 1140 gctggagggc gcgccccggc ccgtggcccg cgagaagacc tcgctgggca gcctgaagcg 1200 cgccagcgtg gacgtggacc tgctggcccc gcgcagcccc atggccaagg agaacatggt 1260 gaccttcagc cacacgctgc ccagggccag cgcgccctcg ctggacgacc ccgcgcgccg 1320 ccacatgacc atccacgtgc cgctggacgc ctcgcgctcc aagcagctca tcagcgagtg 1380 gaagcagaag agcctggagg gccgcggcct ggggctgccc gacgacgcca gccccgggca 1440 cctgcgcgcg cccgccgaac ccatggcgga ggaggaggaa gaggaggagg acgaagagga 1500 agaggaggag gaggaagagg aggaggacga gggcccggcc ccgccctcgc tctaccccac 1560 cgtgcaggcg cggccggggc tggggcctcg ggtcatcctc ccaccgcgcg cggggccgcc 1620 gccgctggtg cacatcccgg aggagggcgc gcagacgggg gccggcctgt cccccaaaag 1680 cggcgccggg gtgcgcgcca agtggctcat gatggccgag aagagcgggg cggcagtggc 1740 caaccctccg cggctgctgc aggtcatcgc catgtccaag gctccgggcg cgccgggccc 1800 caaggcggcc gagacggcgt cgtcgtccag cgccagctcc gactcctcgc agtaccggtc 1860 gccgtcggac cgcgactccg ccagcatcgt gaccatcgac gcgcacgcgc cgcaccaccc 1920 cgtggtgcac ctgtcggccg gcggcgcgcc ctgggagtgg aaggcggcgg gcggcggggc 1980 caaggcggag gccgacggcg gctacgagct gggggacctg gcgcgcggct tccgcggcgg 2040 ggccaagccc ccgggcgtgt cccccggctc gtcggtcagc gacgtggacc aggaggagcc 2100 gcggttcggg gccgtggcca ccgtcaacct ggccacgggc gaggggctgc ccccgctggg 2160 cgcggccgat ggggcgctgg gcccgggcag ccgggagtcc acgctgcggc gccacgcggg 2220 cggcctgggg ctggcggagc gcgaggcgga ggcggaggcc gagggctact tccgcaagat 2280 gcaggcgcgc cgcttccccg actagcgcgg cggggccggg ggcgggcggg gggcgggccg 2340 agggcgcggg cggccgc 2357 <210> 51 <211> 3496 <212> DNA <213> Human <400> 51 aagattttac tgacaatttg gagctagatg aagaaggagc aggcgggttc acggctaaag 60 caatcgttca gagagacaga gtggatgaag aggccttgaa tttcccctac gaggatgact 120 ttgacaacga tgtggatgct ctgctggaag aaggcctttg tgcccccaaa aagaggcgaa 180 cagaggaaaa atatggcgga gacagcgacc atctgtccga tggagagaca agtgtgcagc 240 cgatgatgac caagattaaa acagtgctca aaagtcgtgg ccgcccacct acagagccgc 300 tgcccgacgg gtggatcatg acattccata actctggagt cccggtgtac ctacacagag 360 agtctcgggt ggtcacctgg tccaggccat acttcttggg aacgggaagc atacggaaat 420 acgaccctcc tctgagtagc atcccttgtc tgcattataa gaaaatgaag gacaacgagg 480 aacgggagca aagcagtgac ctcaccccta gtggggatgt gtcccccgtc aagcccctga 540 gccgatctgc agagctggag tttcccctgg atgagcctga ctctatgggt gctgacccgg 600 ggcccccgga cgagaaagac ccactagggg ctgaggcagc ccctggggcc ctggggcagg 660 tgaaggccaa agtcgaggtg tgcaaagatg aatccgttga tctcgaggaa tttcgaagct 720 acctggagaa gcgttttgac tttgagcaag ttactgtgaa aaaattcagg acttgggctg 780 agcggcggca attcaatcgg gaaatgaagc ggaagcaggc ggagtccgag aggcccatct 840 tgccagccaa tcagaagctc attactttat cagtgcaaga tgcacccaca aagaaagagt 900 ttgttattaa ccccaacggg aaatccgagg tctgcatcct gcacgagtac atgcagcgtg 960 tcctcaaggt ccgccctgtc tataatttct ttgaatgtga gaacccaagt gagccttttg 1020 gtgcctcggt gaccattgat ggtgtgactt acggatctgg aactgcaagc agcaaaaaac 1080 ttgcgaagaa taaagctgcc cgagctacac tggaaatcct catccctgac tttgttaaac 1140 agacctctga agagaagccc aaagacagtg aagaactcga gtattttaac cacatcagca 1200 tcgaggactc gcgggtctac gagctgacca gcaaggctgg gctgttgtct ccatatcaga 1260 tcctccacga gtgccttaaa agaaaccatg ggatgggtga cacgtctatc aagtttgaag 1320 tggttcctgg gaaaaaccag aagagtgaat acgtcatggc gtgtggcaag cacacagtgc 1380 gcgggtggtg taagaacaag agagttggaa agcagttagc ctcacagaag atccttcagc 1440 tgctgcaccc acatgtcaag aactgggggt ctttactgcg catgtatggc cgtgagagca 1500 gcaagatggc caagcaggag acatcggaca agagtgtgat tgagctgcag cagtatgcca 1560 agaagaacaa gcccaacctg cacatcctca gcaagctcca agaggagatg aagaggctag 1620 ctgaggaaag ggaggagact cgaaagaagc ccaagatgtc cattgtggcg tccgcccagc 1680 ctggcggtga gcccctgtgc accgtggacg tgtgagggag gtggcacggg ccagggcgcg 1740 ggggccgcca gccgcacttc tgaggagacc agcagtcatg catcgtgcac cacagtgtca 1800 ggcctccaac ccacgctcct tccctgtggc caacctgtgg gcccggcctt agggtggaga 1860 ctttagtgta cagggacagc catggccaca cagcacacat gtggagcagc ggctctccct 1920 ggaaagctcc aggcctgaat ggatggactc agcgactgca ccagtggcag ctggtgactg 1980 tggacagtgg tggaccctgc ttctgtgcac ctgctgcagg ctctttttat gaaggctttc 2040 atgaatttta gtatgtaata cgcactgacg acacatgatg cttggatgac agatgagagg 2100 ggatggctga gtcctgtggc tggcccgtga tgccaggtgg cccatgtgcc cagggcgcct 2160 gcagggctgc tacagggacc tggtcaggag gtgcacatgg tgccctgccc tcacccaccc 2220 tctgtgtttc cccttctttg aaaaggtaga agagaaagga atattttaaa cctttttggc 2280 ttaaacagaa ttttagcatc agaactagct ttctgggatt ggaggcaaac catcaaggtg 2340 gtccctctcc agtctggaca cgatgccagc aaggatgacg tcctgccacc tcctggagtt 2400 accctggcct cctagggtcc ctttttctga tgaagtctta attccctaaa agcgcctctt 2460 tggacactga ggccctctct gcctttcctg gcctccggca acagtttttt tacaaagatt 2520 ttttgcagtc gagtccatat gtccacccat tgatttttaa agcttttgtg atattttagc 2580 attttgaaag actttcacag tgagagtaga aggtagattt ggaatcatgc attttagcaa 2640 gtggacttgt tgaaacagga agcaagggcc ttcagtgtag cccattcttg atccagagct 2700 gttgcctgtg acagcggttt ctctggatgt caaaggcagc tgcctggtgc ccagcttgct 2760 tctcgactgg tggcccctat gggtgggtgt gcgatggaaa tgtgttcctg ccggagtctg 2820 aggcaccagg gtgtgctcaa aggctggccc tggtggtgga ctggcacctg tgcagagtgc 2880 cgtgtgcttg tggtgcgcca tctgaagcaa gagtccagcg ttctgccgtg tctgtccccc 2940 accatgcccc ctacaggcgg tactgatggc gctttttttt ttttttttct gtcaggaaaa 3000 caatgttggc ctgtgggccg cccacaacat atccttccct cactacctgt gtgaccaagg 3060 ttggcttctg ttgacctttt aaaaaagaaa ccctcaactc aaattgctat aattagacac 3120 ttgcttctgt cttgcctcct gtctgcagct gtgaatagtc atttgactgt gactgttgcc 3180 cttagccagc cagatgcgcc tgtgaaccaa agcttcgtgc acatgtgttc ccctaaaggt 3240 tggggagcct cgctgtgtct tgctgttccc aggcaccacc acagcaggtg ctgccatact 3300 cttgtggtct ctgtgcgccc cccccccccc cacccgtctg ccaagcatgg gtatgaatcg 3360 tgcacacagc catgcttcaa ggccggggca ggggagcctg tgctgatgcc atccagggca 3420 ctgggctgtg cctggaaggc gagccttgat tgtctgaaca cataaagcaa actgtccaga 3480 aaaaaaaaaa aaaaaa 3496 <210> 52 <211> 3508 <212> DNA <213> Human <400> 52 gcaacagccc agccctagct tgggagcgga cccacacgaa ctgctcaaag gcttggagcg 60 ggtctagtaa ggcgaacgga ctgcttccgg ccagaggtcc cgggcggagg aggaagctgt 120 ggctgccggc ggtgggacgc cccggccgct cagcccccgg gcactgctgt ggggcgttca 180 gctttccaca cttggggcaa agcaagccgc gaggaggaac cagacagtcc tgttagttgt 240 ggccagccct cattccctgg aaatggcaaa caaggggaac aagaagcgtc ggcagttctc 300 tctggaggag aaaatgaaag ttgtgggagc tgtagactca ggcaagagga aaggtgatgt 360 ggcaaaagaa tttggtatca ctccctctac tttatctaca ttcttaaagg atcgcaccaa 420 atttgaagaa aaggtgcggg aggcatccgt gggaccccag cggaaaagga tgaggagcgc 480 tctttatgat gacattgata aggctgtttt tgcttggttt caagaaatcc atgccaaaaa 540 cattcttgtg actggttctg tcattcggaa aaaagcacta aacttggcca acatgcttgg 600 ctatgacaat tttcaagcaa gtgtgggctg gctgaacaga tttagagatc gccacggaat 660 tgctttgaaa gcagtctgta gagaagatag tgacaggtta atgaatggtc taggaataga 720 taagattaat gagtggcatg caggggaaat tataaaactg attgctgact acagcccaga 780 tgatatcttt aatgctgatg agacaggagt gtttttccag ttgcttcccc agcacacact 840 tgctgctaaa ggagaccact gtagaggggg caagaaagca aagcagcggt tgacagcact 900 cttttgttgc aatgcctcgg ggactgaaaa aatgagacca ttgattgttg gtaggtcagc 960 cagcccacac tgcctcaaga acattcattc cctcccttgt gattaccgag ccaaccagtg 1020 ggcttggatg acaagggatc tgtttaatga gtggctgatg caagtggatg ccaggatgaa 1080 gagggcggaa cgccggatcc tcttgctcat agacaactgc tctgctcata acatgcttcc 1140 acacttggaa aggattcagg ttgggtatct gccctccaac tgtactgctg tcctgcagcc 1200 actgaatctt ggcataattc acaccatgaa agtactgtac cagagccacc ttctaaaaca 1260 gatcctcctc aagctcaaca gcagtgagga tcaagaagag gtggacatca agcaggccat 1320 cgacatgatt gctgcagcgt ggtggtcagt caagccatcc acagtggtga aatgttggca 1380 gaaggcaggc atcgtcccta tggaatttgc agaatgtgac acagaatcag cagccagtga 1440 accagacatt gccattgaaa agttgtggca cacagtggct attgccacct gtgtcccaaa 1500 tgaagtaaat ttccaggact ttgttactgc agatgatgat ctcattatct ctcaggacac 1560 agacatcatc caggacatgg tggctggcga aaataccagt gaagcaggaa gtgaagatga 1620 aggggaggta tctttaccag agcaaccaaa agtcaccatc acagaagcca tatcaagtgt 1680 acagaaactt agacagttcc tttccacttg tgtagacatt cctgatgcca tttttggaca 1740 attaaatggc atagatgaat atttaatgaa aagagtgaca caaaccctta ttgattccaa 1800 aattacagat ttcctccaaa caaaataatg caggaattta tttcagaaaa tgtagtttac 1860 aagaataaag atttctttag ataggttgtt gagccaattt aagtaaagca atgttattgt 1920 gacaacattc cagtactctg aaatagccag gaaacttctt tgaatggaat ttgactaata 1980 tgtgtgtttt cttttctttt gtttttggct gtctctggtc cttgattcaa gatgtatttt 2040 gattcatcca agggtttcca aacttgtctg caaattagga tcacttgaga atcctttaaa 2100 aattccaaag ctcaggccat atcccaggcc tattaaatca caatctttgg tgacgggtca 2160 caggcattgg tagttttgaa gctctccagg tgattccaat gtgcagacaa atttgaaaac 2220 tgaaccaacc acaggaacat caagtacact gtgggcctgg gtccagcttc tttccagtaa 2280 gtgtatctca ggggcttcca aatttagctt acatcagaat cacttggaag gcttgttaaa 2340 acccaaggct gctaggccca cccccagagt ttgatacagt agacctcagg tgggacccaa 2400 aaatttgcat ttctaacaca ttctcagctg atgcagtcca ggctccatgc tttgaaaacc 2460 actggtctag ctttagatag gatattgagc caatttaaat aaagcaatat actggtctag 2520 ctgagttcta gaacttctct ctttagctgg ccatctgaat actcccccat cactaattgt 2580 taaaaaaaga atcaactgtt cttactctag agctcttttt tcctttctgc tgatttgctg 2640 gaagcactac aagacttctg tttgttcgtt cgtttgtttg tttgtttgtt tttaaagatg 2700 gggtcttgtt atattgccta ggctggaatg cagtggttat tcacaggcat gattataaca 2760 cactactctc tctaactcct ggcctcaagc catcctccca aatagatggg actactgatg 2820 cacactgcca tgctggcctt acgaaatgtt ttaataggca tttcactaat agggatctgg 2880 agtacaagga aatacagtgc atttaagaca taggctgggc atggtggctc atgcctgtaa 2940 tcccagcaca ttgggaagat cacttgaggc aaggagtttg agaccagact ggccaacaca 3000 gcgagacccc catctctaaa aaaaaaaaaa ttaataagac atggatacaa ccagggaggg 3060 aggttataat aatagagcat cctgttaatc agaatcatgg gggagaacat acagcccagc 3120 gtgcctctca ctttccagaa agggtgagag gatcattaga gagttcatta gagagtattt 3180 attcctaata agtcagataa atgtcagttt catttttaga agtttcacac aatacctgct 3240 aatggtgtga tgtcattttt ccccctgctt caggttaatt ttttggatat ttcagaaacc 3300 catagcaatt cagtgatttt tctttttgta gtagctcagt caaaacaggt aacagcagat 3360 taatcataga aaatgttgct tccacattaa caaaacaatc actgaaaaac agcagatgtt 3420 taaatagatt attttatagc ttattttgga tattttttct tttaataaac taatatgatc 3480 atttgaatta aaaaaaaaaa aaaaaaaa 3508 <210> 53 <211> 1391 <212> DNA <213> Human <400> 53 tgcactcacc tcctagagac caggctgcca tcatgctctg gaagcttgtg gagaatgtca 60 agtacgaaga tatctatgag gaccggcacg atggtgtccc gagccacagc tcgcggctct 120 cccagctggg ctcggtgtcc caaggaccct actcgagcgc cccgccgctg tcccacaccc 180 cgtcgtcgga cttccagccg ccctacttcc caccccccta ccagccgctc ccctaccacc 240 agagccagga cccctactcc cacgtcaacg acccctactc cctgaaccca ctgcaccagc 300 cccagcaaca tccctggggg caacggcagc ggcaagaagt gggttcggaa gccggctctc 360 tcctgcccca gcctcgggcc gccttgcccc agctctcggg ccttgacccc cggagggact 420 accactcggt ccgccggccg gacgtgctgc tgcattcggc gcaccacggc ctggacgcgg 480 gcatgggtga cagcctctcg ctgcacggcc tcggccatcc cggaatggaa gacgtccagt 540 cagttgaaga tgccaataac agcggcatga atctattgga ccagtctgtc attaaaaaag 600 ttccagttcc tcccaaatcg gtgacttctc taatgatgaa taaagacggc ttcctgggag 660 gcatgtctgt caacaccggc gaggtgtttt gctccgtccc aggccgtttg tctctgctca 720 gttcaacttc gaagtacaaa gtaactgtgg gagaagttca gagacggctg tcgccccctg 780 aatgcctcaa tgcatctctc ctcggcggag tcctcagaag agccaaatcg aaaaatgggg 840 ggagatcttt gcgagaaagg ctagaaaaaa tcggtttgaa tttacccgcg ggcaggcgca 900 aagcagcaaa tgtcacgtta ctcacctccc tggtggaagg agaagctgtt cacttagcta 960 gggattttgg gtacatttgc gaaacggagt ttcccgccaa agccgtctct gagtatttga 1020 accggcagca cacagacccg agtgacctgc actcccgaaa gaatatgctg ttggccacca 1080 agcaactttg taaagaattt acggatctac tggcgcagga ccggacaccg atagggaaca 1140 gccgacccag ccccatcctg gagccgggga tccagagctg cctcacgcac ttcagcctca 1200 tcacgcacgg cttcggcgcc ccggccattt gcgccgcgct cacggccctg cagaactatc 1260 tcaccgaggc gctcaaaggc atggacaaga tgttcttgaa caacaccacc actaacaggc 1320 acacgtctgg ggaaggccca ggtagtaaaa ctggcgacaa ggaggagaaa cacaggaaat 1380 gaaaaatttt t 1391 <210> 54 <211> 4862 <212> DNA <213> Human <400> 54 acgcagctcc gccccgcgtc cgacccgcgg atcccgcggc gtccggcccg ggtggtctgg 60 atcgcggagg gaatgccccg gagggcggag aactgggacg aggccgaggt aggcgcggag 120 gaggcaggcg tcgaagagta cggccctgaa gaagacggcg gggaggagtc gggcgccgag 180 gagtccggcc cggaagagtc cggcccggag gaactgggcg ccgaggagga gatggaggcc 240 gggcggccgc ggcccgtgct gcgctcggtg aactcgcgcg agccctccca ggtcatcttc 300 tgcaatcgca gtccgcgcgt cgtgctgccc gtatggctca acttcgacgg cgagccgcag 360 ccctacccaa cgctgccgcc tggcacgggc cgccgcatcc acagctaccg aggtcacctt 420 tggctcttca gagatgcagg gacacacgat gggcttctgg ttaaccaaac tgaattattt 480 gtgccatctc tcaatgttga cggacagcct atttttgcca atatcacact gccagtgtat 540 actctgaaag agcgatgcct ccaggttgtc cggagcctag tcaagcctga gaattacagg 600 agactggaca tcgtcaggtc gctctacgaa gatctggaag accacccaaa tgtgcagaaa 660 gacctggagc ggctgacaca ggagcgcatt gcacatcaac ggatgggaga ttgaagattt 720 ctgttgaaac ttacactgtt tcatctcagc ttttgatggt actgatgagt cttgatctag 780 atacaggact ggttccttcc ttagtttcaa agtgtctcat tctcagagta aaataggcac 840 cattgcttaa aagaaagtta actgacttca ctaggcattg tgatgtttag gggcaaacat 900 cacaaaatgt aatttaatgc ctgcccatta gagaagtatt tatcaggaga aggtggtggc 960 atttttgctt cctagtaagt caggacagct tgtatgtaag gaggtttata taagtaattc 1020 agtgggaatt gcagcatatc gtttaatttt aagaaggcat tggcatctgc ttttaatgga 1080 tgtataatac atccattcta catccgtagc ggttggtgac ttgtctgcct cctgctttgg 1140 gaagactgag gcatccgtga ggcagggaca agtctttctc ctctttgaga ccccagtgcc 1200 tgcacatcat gagccttcag tcagggtttg tcagaggaac aaaccagggg acactttgtt 1260 agaaagtgct tagaggttct gcctctattt ttgttggggg gtgggagagg ggaccttaaa 1320 atgtgtacag tgaacaaatg tcttaaaggg aatcattttt gtaggaagca ttttttataa 1380 ttttctaagt cgtgcacttt ctcggtccac tcttgttgaa gtgctgtttt attactgttt 1440 ctaaactagg attgacattc tacagttgtg ataatagcat ttttgtaact tgccatccgc 1500 acagaaaata cgagaaaatc tgcatgtttg attatagtat taatggacaa ataagttttt 1560 gctaaatgtg agtatttctg ttcctttttg taaatatgtg acattcctga ttgatttggg 1620 tttttttgtt gttgttgttt tgttttgttt tgtttttttg ggatggagkc tcactcttgt 1680 cacccaggct ggagtgcagt ggcgccatct cggctcactg caacctctgc ctcctgagtt 1740 cacgtaatcc tcctgagtag ctgggattac aggtgcctgc caccacgctg gccaattttt 1800 gtacttttag tagagacagt gtttcgccat gttggccagg ctggtttcaa actcctgacc 1860 tcaggtgatc cgcccacctc agcctcccaa aatggtggga ttacaggtgt gtgggccacc 1920 gtgcctggct gattcagcat tttttatcag gcaggaccag gtggacttcc acctccagcc 1980 tctggtccta ccaatggatt catggagtag cctggactgt ttcatagttt tctaaatgta 2040 caaattctta taggctagac ttagattcat taactcaaat tcaatgcttc tatcagactc 2100 agttttttgt aactaataga tttttttttc cacttttgtt ctactccttc cctaatagct 2160 ttttaaaaaa atctccccag tagagaaaca tttggaaaag acagaaaact aaaaaggaag 2220 aaaaaagatc cctattagat acacttctta aatacaatca cattaacatt ttgagctatt 2280 tccttccagc ctttttaggg cagattttgg ttggttttta catagttgag attgtactgt 2340 tcatacagtt ttataccctt tttcatttaa ctttataact taaatattgc tctatgttag 2400 tataagcttt tcacaaacat tagtatagtc tcccttttat aattaatgtt tgtgggtatt 2460 tcttggcatg catctttaat tccttatcct agcctttggg cacaattcct gtgctcaaaa 2520 atgagagtga cggctggcat ggtggctccc gcctgtaatc ccagtacttt gggaagccaa 2580 ggtaagagga ttgcttgagc ccagaacttc aagatgagcc tgggctcata gtgagaaccc 2640 gtctatacaa aaaattttta aaaattagca tggcggcaca catctgtaat cctagctact 2700 tggcaggctg aggtgagaag atcattggag tttaggaatt ggaggcggca gtgagtcatg 2760 agtatgccgc tgcactccag cctgggggac agagcaagac cctgcctcaa aaaaaaaaaa 2820 aaaaaaaatt caggccggga atggtggttc acgcctgtaa tcccagcact ttggggggtc 2880 gaggtgggca gatcacctga ggtcaggagt tcgagaccag cctggccaac atggtaaaac 2940 cccatttcta ctaaaaaata caagaattag ctgggtgtgg tggcgcatgc ctgtaatcct 3000 agctactcag gaggctgagg caggagaatc acttgacccc aggaggcgaa gattgcagtg 3060 agctgatatc gcaccattgt actccagcct gtgtgacaga gcaatactct tgtcccaaaa 3120 aaaaaaaaaa ttcaaatcag agtgaagtga atgagacact ccagttttcc ttctactccg 3180 aattttagct cctcctttca acattcaaca aatagtcttt tttttttttt tttttttttg 3240 gggatggagt ctccctctgt tgcccaggct ggagtgcaga ggtgcgatct ctgctcacta 3300 caagctctgc ctcccgagtt caagtgattc tcctggctca ccctcctgag ctgggattac 3360 aggcgcctgc caccatgcct ggctaatttt gtgtttttag tggagacggg gtttcaccat 3420 gttgtccagg atggtcttga tctcctgacc ttgtgatcca cccacctcag cctcccaaag 3480 tggtgggatt acaggtgtga gccaccgcgt ccagccagct ttattatttt ttttaagctg 3540 tctttgtgtc aaaatgatag ttcatgctcc tcttgttaaa acctgcaggc cgagcacagt 3600 ggctcatgcc tgtaatccca gcattttggg agaccaaggc ggatggatca cctgaggtca 3660 ggagctcaag accagcctgg ctaacatggt gaaacctcat ctccacttaa aatacaaaaa 3720 ttgccggccg cggcggctca tgcctgtaat cccagcactt tgggaggcct aggcgggtgg 3780 atcacgacgt caggaaatcg agaccatcct ggctaacacg ggtgaaaccc cgtctctatt 3840 aaaaaataga aaaaattagg cgggcgtggt ggtgagcgcc tgtagtccca gctactcgag 3900 agcctgaggc aggagaatgg catgaacctg gaaggtggag cttgcagtga gctgagatgg 3960 tgccactgca ctctaacctg ggcgacagag tgagactccg tctcaaaaaa aaaaacaaaa 4020 accaaaactt atccaggtgt ggcggtgggc gcctgtgagg caggcgaatc tcttgaaccc 4080 gggaggcgga ggttgcagtg agccaagatc acaccattgc actccagcct gggaaacaag 4140 agtgaaattc catctcaaaa ccaaattttc aaaaaaaaaa catgccgctt gagtactgtg 4200 tttttggtgt tgtccaagga aaattaaaac ctgtagcatg aataatgttt gttttcattt 4260 cgaatcttgt gaatgtatta aatatatcgc tcttaagaga cggtgaagtt cctatttcaa 4320 gttttttttg ttttgttttg tttttaagct gttttttaat acattaaatg gtgctgagta 4380 aaggaaatag gcagggtgtg ttgtgtggtg ttttaactag gcgcttctct ctcagagagt 4440 tttgaaacct gtttacataa aggcccaaga tgggaaggag atccaaacat aagccaccag 4500 cctcattcca agtctcttct ctttccaacc ctggattttt tttttttatt taacattgtt 4560 tcttttagct ttatttttct tataaaagaa atgtatcact ataaaaaatt acacactaca 4620 gaaaaatatt aagaagaaaa acattcacat cggaaacaaa gttttttccc atgaaaacag 4680 aacccaaaag ggtaagtggt tagtatttca ccagcaatta tgttgagaat aaggccaggc 4740 gaggtggctc acgcctgtaa tctcagcact ttgggaggcc agggcaggca gatcatctga 4800 ggtcaggagt ttgagaccag cctggccaac atggtgaaac cctatctcta ctaaaaatta 4860 aa 4862 <210> 55 <211> 3568 <212> DNA <213> Human <400> 55 atagttttca ggttaagaaa gccagaatct ttgttcagcc acactgactg aacagacttt 60 tagtggggtt acctggctaa cagcagcagc ggcaacggca gcagcagcag cagcagcagc 120 agcagcagca gcagggctcc tgggataact caggcatagt tcaacactat gggtcctcct 180 ctgaagctct tcaaaaacca gaaataccag gaactgaagc aggaatgcat caaagacagc 240 agacttttct gtgatccaac atttctgcct gagaatgatt ctcttttcta caaccgactg 300 cttcctggaa aggtggtgtg gaaacgtccc caggacatct gtgatgaccc ccatctgatt 360 gtgggcaaca ttagcaacca ccagctgacc caagggagac tggggcacaa gccaatggtt 420 tctgcatttt cctgtttggc tgttcaggag tctcattgga caaagacaat tcccaaccat 480 aaggaacagg aatgggaccc tcaaaaaaca gaaaaatacg ctgggatatt tcactttcgt 540 ttctggcatt ttggagaatg gactgaagtg gtgattgatg acttgttgcc caccattaac 600 ggagatctgg tcttctcttt ctccacttcc atgaatgagt tttggaatgc tctgctggaa 660 aaagcttatg caaagctgct aggctgttat gaggccctgg atggtttgac catcactgat 720 attattgtgg acttcacggg cacattggct gaaactgttg acatgcagaa aggaagatac 780 actgagcttg ttgaggagaa gtacaagcta ttcggagaac tgtacaaaac atttaccaaa 840 ggtggtctga tctgctgttc cattgagtct cccaatcagg aggagcaaga agttgaaact 900 gattggggtc tgctgaaggg ccatacctat accatgactg atattcgcaa aattcgtctt 960 ggagagagac ttgtggaagt cttcagtgct gagaaggtgt atatggttcg cctgagaaac 1020 cccttgggaa gacaggaatg gagtggcccc tggagtgaaa tttctgaaga gtggcagcaa 1080 ctgactgcat cagatcgcaa gaacctgggg cttgttatgt ctgatgatgg agagttttgg 1140 atgagcttgg aggacttttg ccgcaacttt cacaaactga atgtctgccg caatgtgaac 1200 aaccctattt ttggccgaaa ggagctggaa tcggtgttgg gatgctggac tgtggatgat 1260 gatcccctga tgaaccgctc aggaggctgc tataacaacc gtgatacctt cctgcagaat 1320 ccccagtaca tcttcactgt gcctgaggat gggcacaagg tcattatgtc actgcagcag 1380 aaggacctgc gcacttaccg ccgaatggga agacctgaca attacatcat tggctttgag 1440 ctcttcaagg tggagatgaa ccgcaaattc cgcctccacc acctctacat ccaggagcgt 1500 gctgggactt ccacctatat tgacacccgc acagtgtttc tgagcaagta cctgaagaag 1560 ggcaactatg tgcttgtccc aaccatgttc cagcatggtc gcaccagcga gtttctcctg 1620 agaatcttct ctgaagtgcc tgtccagctc agggaactga ctctggacat gcccaaaatg 1680 tcctgctgga acctggctcg tggctacccg aaagtagtta ctcagatcac tgttcacagt 1740 gctgaggacc tggagaagaa gtatgccaat gaaactgtaa acccatattt ggtcatcaaa 1800 tgtggaaagg aggaagtccg ttctcctgtc cagaagaata cagttcatgc catttttgac 1860 acccaggcca ttttctacag aaggaccact gacattccta ttatagtaca ggtctggaac 1920 agccgaaaat tctgtgatca gttcttgggg caggttactc tggatgctga ccccagcgac 1980 tgccgtgatc tgaagtctct gtacctgcgt aagaagggtg gtccaactgc caaagtcaag 2040 caaggccaca tcagcttcaa ggttatttcc agcgatgatc tcactgagct ctaaatctgc 2100 aatcccagag aatcctgaca aagcgtgcca cccttttatt ttccgtcagg tgccaggtct 2160 tagttaagat tcacaatctt tagaaagaat gagattcaca ataattaact cttcctctct 2220 tctgataaat tccccatacc tcccaatcca agtagcatct gtagctacat aacctatata 2280 cctccagcag ctggacatgg ggaggcgaca gtcctatcta gacatcatac acatttgcca 2340 agaaaggatc tctggggctt ccgggggtga gattcaagca ggacaataac aagaggctgg 2400 acaccctaca gatgtctttg atgttttcag ttgtttgata tatctcccct gtagggcatg 2460 ttgaggaagg aggagggctg atcaaggcca agctggtcta gcctgacatc ctagctcctg 2520 actgaacact atagacttcc cagcagcatt tcacccagca gccagagccg gctttaagtc 2580 cccaaccctt acagacacca ctgccaccac caccaaccac gaccaccacc accaccacca 2640 ctcaccacca tcatcacctc cggaaagtgt agtcctgccc taacccaagt cacccccgac 2700 agtaaatttt accttcatgt tgagaaagct tcctggtgct taatcaagag ctggagttca 2760 atgagtccta gacagtgaga ggggcctgag cttcagctca atggaagcct gctgtgtgcc 2820 acaagacgga aaagtggaag aagctgcagt gggagacaaa gcctcggtcc cccacccatc 2880 cacacacacc tacactcaca cacgcgcaca tgggcgcgca cgaactacca ttcaggcagt 2940 cagtgggcaa gaggaaagat aagtaagtac catacacacc taaaagatga gagaattcat 3000 ccagacatat tacagccagt ttggggcccc tgactgcaat gtgaaacctc tcgctgctgc 3060 taggtttaca aacaagccca ttgtcctgtg cctcctaata tcatttgtac tgaagacccc 3120 atctggggac ttgagacttt ggtcccagcc cagactcctc agacttttct ctcagttggg 3180 atgcttcact cgctgggggt gtttgtttgc cctctcattt ttcagtactt ctacagaatt 3240 ttctctagag tcagtcatta tgaaatgtac ttccctccat cttaacctat caactttctg 3300 cccctccttc aaggcccagt ataaatgcca cctcctccat gaagccttcc ctaattccac 3360 cccaaacccc caccttcaac aatatttcaa cgcttctgca atgatgaaaa agaaacatag 3420 ttgtagtact tagcctacct agaccagcaa gcattcattt ttagctcgct cattttttac 3480 catgttttcc agtctgttta acttctgcag tgccttcact acactgcctt acataaacca 3540 aatcacaata aagttcatat tcagtaca 3568 <210> 56 <211> 1955 <212> DNA <213> Human <400> 56 gaattcacca agcgttggat tgttcaccca ctaataggga acgtgagctg ggtttagacc 60 gtcgtgagac aggttagttt taccctactg atgatgtgtt gttgccatgg taatcctgct 120 cagtacgaga ggaaccgcag gttcagacat ttggtgtatg tgcttggctg aggagccaat 180 ggggcgaacg taccatctgt gggattatga ctgaacgcct ctaagtcaga atcccgccca 240 ggcgaacgat acggcagcgc cgcggagcct cggttggcct cggatagccg gtcccccgcc 300 tgtccccgcc ggcgggccgc ccccccctcc agcgccccgc gcgcgcggga gggcgcgtgc 360 cccgccgcgc gccgggaccg gggtccggtg cggagtgccc ttcgtcctgg gaaacggggc 420 gcggccggaa aggcggccgc cccctcgccc gtcacgcacc gcacgttcgt ggggaacctg 480 gcgctaaacc attcgtagac gacctgcttc tgggtcgggg tttcgtacgt agcagagcag 540 ctccctcgct gcgatctatt gaaagtcagc cctcgacaca agggtttgtc cgcgcgcgcg 600 gcggcgtgcg tgcggggggc ccggcggggc gtgcgcgtcc ggcgccgtcc gtccttccgt 660 tcgtcttcct ccctcccggc ctctccgccg accgcgggcg tggtgggggg gtgggggggg 720 gacgcgcgac cccggtcggc gcgccccgct tcttcggttc ccgcctcctc cccgttcacc 780 gcggggcggc tcgtccgctc cgggccggga cggggtccgg ggagcgtggt ttgggagccg 840 cggaggcggc cgcgccgagc cgggcccgtg cgcggtcccc gtcccggggg ttggccgcgc 900 gggccccggt ggggccaccc ggggtcccgg ccctcgcgcg tccttcctct cgctcctccg 960 cacgggtcga ccagcagacc gcgggtggtg ggcggcgggc ggcgaggccg cacgggcgtc 1020 cccgcacccg gccgacctcc gctcgtgacc tctcctcggt cgggctccgg ggtcgaccgc 1080 ctgccccgcg ggcgtgagac tcagccgctg tctcgccgtg tcccgggtcg accggcgggc 1140 ttctccaccg agcggcgtgt aggagtgccc gtcgggacga accgcaaccg gagcgtcccc 1200 gtctcggtcg gcacctccgg ggtcgaccag ctgccgcccg cgagctccgg acttagccgg 1260 cgcctgcacg tgtcccgggt cgaccagcag gcggccgcga cgtgcggcgc accgacgaga 1320 gggcgtgcat tcccgttcgc gcgcccggac cctccaccgg cctgggcccg acggtggagc 1380 tgggaccacg cggaactccc tctcctacat ttttttcagc cccaccgcga gtttgcgtcc 1440 gcgggatttt aagagggagt cactgctgcc gtcagccagt aatgcttcct ccttttttgc 1500 ttttaggttt tgctcttgcc tttttttttt tttttttctt tctttctttc tttctttctt 1560 tctttctttc tttctttctt tctttctcgc tctcgcctct cgctctctcc ctcgctcgtt 1620 ttctttctct ttctctttct ctctctctct ctctctctct ctctctgtct ctcgctctcg 1680 ccctctctct ctctctcttc tctctgtctc tctctgtctc tctctctctc tctctctctc 1740 tctctctctc tctctctctc tctctctccc tccccctccc tccctctctc cccttccttg 1800 gtgccttctc ggctcttgac acttagccgc tgtctcgccg tgtcccgggt cgaccggcgg 1860 gccttctcca ccgagcggcg tgtaagagtg cccgtcggga cgagccggac ccgccgcgtc 1920 cccgtctcgg tcggcactcc ggggtcgacc agctg 1955

Claims (36)

  1. 서열 식별 번호 1 내지 56으로 이루어진 군으로부터 선택되는 유전자의 조합에서 (정상적인 개체에서 동일한 유전자의 발현에 대한) 각 유전자의 차별적인 조정을 확인함을 포함하는, 유방암 상태의 평가 방법.
  2. 제 1 항에 있어서,
    조정된 유전자의 발현에 2배 이상의 차이가 있는 방법.
  3. 제 1 항에 있어서,
    선택되는 유전자가 재발 또는 전이의 표시로서 상향-변동되는(up-regulated) 것인 방법.
  4. 제 1 항에 있어서,
    선택되는 유전자가 재발 또는 전이의 표시로서 하향-변동되는 것인 방법.
  5. 제 1 항에 있어서,
    선택되는 유전자가 서열 식별 번호 1 내지 56을 모두 포함하는 방법.
  6. 제 1 항에 있어서,
    차별적인 조정을 나타내는 p-값이 0.05 미만인 방법.
  7. 제 1 항에 있어서,
    유전자에 기초하지 않은 유방 마커를 추가로 포함하는 방법.
  8. 제 7 항에 있어서,
    유전자에 기초하지 않은 마커가 에스트로겐 수용체(ER) 및 에스트로겐 조절되는 단백질 및 펩티드로 이루어진 군으로부터 선택되는 방법.
  9. 제 1 항에 있어서,
    유전자가 하기 표 4에 기재되어 있는 유전자를 포함하는 방법:
    표 4a
    표 4b
  10. 제 1 항에 있어서,
    유전자가 하기 표 5에 기재되어 있는 유전자를 포함하는 방법:
    표 5
  11. 제 1 항에 있어서,
    유전자가 하기 표 6에 기재되어 있는 유전자를 포함하는 방법:
    표 6
  12. 제 1 항에 있어서,
    유전자가 하기 표 7에 기재되어 있는 유전자를 포함하는 방법:
    표 7
  13. 서열 식별 번호 1 내지 56으로 이루어진 군으로부터 선택되는 유전자의 조합의 단리된 핵산 서열, 이들의 상보물 또는 이들의 일부를 포함하는 예후 포트폴리오(prognostic portfolio).
  14. 제 13 항에 있어서,
    함유된 유전자의 차별적인 발현을 확인하기에 적합한 매트릭스 내의 포트폴리오.
  15. 제 14 항에 있어서,
    상기 매트릭스가 마이크로어레이(microarray)에 사용되는 포트폴리오.
  16. 제 15 항에 있어서,
    상기 마이크로어레이가 cDNA 마이크로어레이인 포트폴리오.
  17. 제 15 항에 있어서,
    상기 마이크로어레이가 올리고뉴클레오티드 마이크로어레이인 포트폴리오.
  18. 서열 식별 번호 1 내지 56으로 이루어진 군으로부터 선택되는 유전자의 조합의 단리된 핵산 서열, 이들의 상보물 또는 이들의 일부를 검출하기 위한 물질을 포함하는, 유방암 환자의 예후를 결정하기 위한 키트.
  19. 제 18 항에 있어서,
    마이크로어레이 분석을 수행하기 위한 시약을 포함하는 키트.
  20. 제 18 항에 있어서,
    상기 핵산 서열, 이들의 상보물 또는 이들의 일부를 분석하는 매체를 추가로 포함하는 키트.
  21. 제 18 항에 있어서,
    유전자가 하기 표 4에 기재되어 있는 유전자를 포함하는 키트:
    표 4a
    표 4b
  22. 제 18 항에 있어서,
    유전자가 하기 표 5에 기재되어 있는 유전자를 포함하는 키트:
    표 5
  23. 제 18 항에 있어서,
    유전자가 하기 표 6에 기재되어 있는 유전자를 포함하는 키트:
    표 6
  24. 제 18 항에 있어서,
    유전자가 하기 표 7에 기재되어 있는 유전자를 포함하는 키트:
    표 7
  25. 서열 식별 번호 1 내지 56으로 이루어진 군으로부터 선택되는 유전자의 조합에서 (정상적인 개체에서 동일한 유전자의 발현에 대한) 각 유전자의 차별적인 조정을 확인함을 포함하는, 유방암 치료에 대한 반응의 평가 방법.
  26. 제 25 항에 있어서,
    유전자가 하기 표 4에 기재되어 있는 유전자를 포함하는 방법:
    표 4a
    표 4b
  27. 제 25 항에 있어서,
    유전자가 하기 표 5에 기재되어 있는 유전자를 포함하는 방법:
    표 5
  28. 제 25 항에 있어서,
    유전자가 하기 표 6에 기재되어 있는 유전자를 포함하는 방법:
    표 6
  29. 제 25 항에 있어서,
    유전자가 하기 표 7에 기재되어 있는 유전자를 포함하는 방법:
    표 7
  30. 서열 식별 번호 1 내지 56으로 이루어진 군으로부터 선택되는 유전자의 조합의 핵산 서열, 이들의 상보물 또는 이들의 일부를 확인하기 위한 물질을 포함하는, 유방암 상태를 평가하기 위한 물품.
  31. 제 30 항에 있어서,
    선택되는 유전자가 상향-변동되고, 서열 식별 번호 1 내지 26 및 서열 식별 번호 56으로 이루어진 군으로부터 추가로 선택되는 물품.
  32. 제 30 항에 있어서,
    선택되는 유전자가 하향-변동되고, 서열 식별 번호 27 내지 55로 이루어진 군으로부터 추가로 선택되는 물품.
  33. 제 30 항에 있어서,
    유전자가 하기 표 4에 기재되어 있는 유전자를 포함하는 물품:
    표 4a
    표 4b
  34. 제 30 항에 있어서,
    유전자가 하기 표 5에 기재되어 있는 유전자를 포함하는 물품:
    표 5
  35. 제 30 항에 있어서,
    유전자가 하기 표 6에 기재되어 있는 유전자를 포함하는 물품:
    표 6
  36. 제 30 항에 있어서,
    유전자가 하기 표 7에 기재되어 있는 유전자를 포함하는 물품:
    표 7
KR1020040028520A 2003-04-24 2004-04-24 유방암 예후 진단방법 KR20040096423A (ko)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100763902B1 (ko) * 2004-02-20 2007-10-05 삼성전자주식회사 유방암 특이적 단백질, 그를 코딩하는 유전자, 및 상기단백질 또는 유전자를 이용한 유방암의 진단 방법
WO2011122857A2 (ko) * 2010-03-30 2011-10-06 서울대학교 산학협력단 유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112622A1 (en) * 2003-08-11 2005-05-26 Ring Brian Z. Reagents and methods for use in cancer diagnosis, classification and therapy
US20060003391A1 (en) * 2003-08-11 2006-01-05 Ring Brian Z Reagents and methods for use in cancer diagnosis, classification and therapy
US20080131916A1 (en) * 2004-08-10 2008-06-05 Ring Brian Z Reagents and Methods For Use In Cancer Diagnosis, Classification and Therapy
WO2006108135A2 (en) * 2005-04-04 2006-10-12 Veridex, Llc Laser microdissection and microarray analysis of breast tumors reveal estrogen receptor related genes and pathways
EP2380978A3 (en) * 2006-02-03 2012-02-29 MessengerScape Co. Ltd. Gene group applicable to cancer prognostication
WO2008094678A2 (en) * 2007-01-31 2008-08-07 Applera Corporation A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
CA2682868A1 (en) * 2007-04-05 2008-10-16 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification, monitoring, and treatment of breast cancer
CN102016881B (zh) * 2008-04-25 2013-06-12 皇家飞利浦电子股份有限公司 样本数据的分类
GB0821787D0 (en) * 2008-12-01 2009-01-07 Univ Ulster A genomic-based method of stratifying breast cancer patients
US8597885B2 (en) * 2009-01-28 2013-12-03 University Of Notre Dame Accelerated progression relapse test
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
AU2013248989A1 (en) * 2012-04-20 2014-11-27 Memorial Sloan-Kettering Cancer Center Gene expression profiles associated with metastatic breast cancer
GB201510684D0 (en) * 2015-06-17 2015-08-05 Almac Diagnostics Ltd Gene signatures predictive of metastatic disease
CN110172461B (zh) * 2019-06-03 2023-05-09 上海长征医院 一种新型骨肉瘤肺转移模型的构建方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500010A (ja) 1997-12-23 2002-01-08 カイロン コーポレイション ヒト遺伝子および遺伝子発現産物ｉ
WO2002010436A2 (en) 2000-07-28 2002-02-07 The Brigham And Women's Hospital, Inc. Prognostic classification of breast cancer
WO2002068579A2 (en) 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
AU2002253878A1 (en) 2001-01-25 2002-08-06 Gene Logic, Inc. Gene expression profiles in breast tissue
ATE503023T1 (de) * 2001-06-18 2011-04-15 Rosetta Inpharmatics Llc Diagnose und prognose von brustkrebspatientinnen
US7171311B2 (en) 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
JP2006519620A (ja) 2003-03-04 2006-08-31 アークチュラス バイオサイエンス，インコーポレイティド 乳がんにおけるｅｒ状態の弁別特性

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100763902B1 (ko) * 2004-02-20 2007-10-05 삼성전자주식회사 유방암 특이적 단백질, 그를 코딩하는 유전자, 및 상기단백질 또는 유전자를 이용한 유방암의 진단 방법
WO2011122857A2 (ko) * 2010-03-30 2011-10-06 서울대학교 산학협력단 유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트
WO2011122857A3 (ko) * 2010-03-30 2012-08-23 서울대학교 산학협력단 유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트

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