KR20040088514A - 2'-ｏ-(2-메톡시)에틸 변형체를 갖는올리고뉴클레오티드를 사용한 ｔｒｐｍ-2 안티센스 치료법 - Google Patents

2'-ｏ-(2-메톡시)에틸 변형체를 갖는올리고뉴클레오티드를 사용한 ｔｒｐｍ-2 안티센스 치료법 Download PDF

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Publication number
KR20040088514A
KR20040088514A KR10-2004-7013102A KR20047013102A KR20040088514A KR 20040088514 A KR20040088514 A KR 20040088514A KR 20047013102 A KR20047013102 A KR 20047013102A KR 20040088514 A KR20040088514 A KR 20040088514A
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South Korea
Prior art keywords
trpm
antisense
nucleotides
oligonucleotide
cells
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KR10-2004-7013102A
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English (en)
Korean (ko)
Inventor
글리브마틴
레니폴에스
미야케히데아키
넬슨콜린
모니아브렛피
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더 유니버시티 오브 브리티쉬 콜롬비아
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Publication of KR20040088514A publication Critical patent/KR20040088514A/ko
Withdrawn legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR10-2004-7013102A 2002-02-22 2003-02-20 2'-ｏ-(2-메톡시)에틸 변형체를 갖는올리고뉴클레오티드를 사용한 ｔｒｐｍ-2 안티센스 치료법 Withdrawn KR20040088514A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/080,794 US6900187B2 (en) 1999-02-26 2002-02-22 TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications
US10/080,794 2002-02-22
PCT/US2003/005305 WO2003072591A1 (en) 2002-02-22 2003-02-20 Trpm-2 antisense therapy using an oligonucleotide having 2'-o-(2-methoxyl)ethyl modifications

Publications (1)

Publication Number Publication Date
KR20040088514A true KR20040088514A (ko) 2004-10-16

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KR10-2004-7013102A Withdrawn KR20040088514A (ko) 2002-02-22 2003-02-20 2'-ｏ-(2-메톡시)에틸 변형체를 갖는올리고뉴클레오티드를 사용한 ｔｒｐｍ-2 안티센스 치료법

Country Status (10)

Country Link
US (1) US6900187B2 (https=)
EP (1) EP1485401A4 (https=)
JP (1) JP2005530486A (https=)
KR (1) KR20040088514A (https=)
AU (1) AU2003213190A1 (https=)
CA (1) CA2475433A1 (https=)
HU (1) HUP0500041A3 (https=)
NO (1) NO20043953L (https=)
NZ (1) NZ534490A (https=)
WO (1) WO2003072591A1 (https=)

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Publication number Priority date Publication date Assignee Title
US6900187B2 (en) 1999-02-26 2005-05-31 The University Of British Columbia TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications
KR100768109B1 (ko) 1999-02-26 2007-10-17 더 유니버시티 오브 브리티쉬 콜롬비아 테스토스테론이 억제된 전립선 메시지-2의 안티센스치료방법
US7569551B2 (en) * 2000-02-25 2009-08-04 The University Of British Columbia Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides
AU2003237616B2 (en) * 2002-01-17 2007-07-05 The University Of British Columbia Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same
NZ538288A (en) * 2002-08-21 2008-04-30 Univ British Columbia Treatment of melanoma by reduction in clusterin levels
EP1578767A4 (en) * 2002-12-04 2008-01-09 Algos Therapeutics Inc METHOD AND MATERIALS FOR MODULATING TRPM2
WO2004092378A2 (en) * 2003-04-18 2004-10-28 The University Of British Columbia Method for treatment of cancerous angiogenic disorders
US20050053981A1 (en) * 2003-09-09 2005-03-10 Swayze Eric E. Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
WO2005094899A1 (en) 2004-04-02 2005-10-13 The University Of British Columbia Clusterin antisense therapy for treatment of cancer
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
EP2397563A3 (en) * 2004-09-17 2012-07-18 Isis Pharmaceuticals, Inc. Enhanced antisense oligonucleotides
DK1814595T3 (da) * 2004-11-23 2014-03-31 Univ British Columbia Behandling af cancer med en kombination af et middel, som forstyrrer EGF-signalvejen og et oligonucleotid, som reducerer clusterinniveauerne
AU2006291990B2 (en) * 2005-09-13 2012-05-31 National Research Council Of Canada Methods and compositions for modulating tumor cell activity
BRPI0616370A2 (pt) * 2005-09-19 2011-06-14 Johnson & Johnson Pharmaceutical Res & Dev L L C modulaÇço da expressço de receptor de glucocorticàide
EP1971371B1 (en) * 2005-12-01 2015-08-05 Pronai Therapeutics, Inc. Cancer therapies and pharmaceutical compositions used therein
CA2631677C (en) 2005-12-01 2014-08-12 Pronai Therapeutics, Inc. Amphoteric liposome formulation
JP5746968B2 (ja) * 2008-07-18 2015-07-08 オンコジェネックス・テクノロジーズ・インコーポレーテッド アンチセンス製剤
AU2008359989A1 (en) * 2008-07-30 2010-02-04 Nitto Denko Corporation Drug carriers
EP2451969A2 (en) 2009-07-07 2012-05-16 University Of Southern California Biomarkers for the early detection of autoimmune diseases
CN102666585B (zh) 2009-11-24 2015-02-18 阿莱斯亚生物疗法股份有限公司 抗簇蛋白抗体和抗原结合片段及其减小肿瘤体积的用途
WO2012123823A1 (en) * 2011-03-15 2012-09-20 The University Of British Columbia Combination of anti-clusterin oligonucleotide with hsp90 inhibitor for the treatment of prostate cancer
JP2015501155A (ja) 2011-10-25 2015-01-15 アイシス ファーマシューティカルズ， インコーポレーテッド Ｇｃｃｒ発現のアンチセンス調整
WO2013123588A1 (en) 2012-02-22 2013-08-29 Alethia Biotherapeutics Inc. Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer
SMT201700339T1 (it) * 2012-04-23 2017-09-07 Biomarin Tech Bv Oligonucleotidi di modulazione dell'rna con caratteristiche migliorate per il trattamento dei disturbi neuromuscolari
UY34812A (es) * 2012-05-18 2013-12-31 Teva Pharma Método para el tratamiento del cáncer de pulmón de células no pequeñas
WO2014100602A1 (en) 2012-12-20 2014-06-26 Hospital For Special Surgery Treatment of egf-receptor dependent pathologies
PT3049085T (pt) 2013-09-26 2021-10-01 Beth Israel Deaconess Medical Ct Inc Inibidores de sgk1 no tratamento da síndrome do qt longo

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Publication number Priority date Publication date Assignee Title
US5789389A (en) * 1995-03-17 1998-08-04 Board Of Trustees Of University Of Illinois BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs
US6383808B1 (en) * 2000-09-11 2002-05-07 Isis Pharmaceuticals, Inc. Antisense inhibition of clusterin expression
JPH11143729A (ja) * 1997-11-07 1999-05-28 Nec Corp フォールトトレラントコンピュータ
US6335194B1 (en) 1998-09-29 2002-01-01 Isis Pharmaceuticals, Inc. Antisense modulation of survivin expression
US6172216B1 (en) * 1998-10-07 2001-01-09 Isis Pharmaceuticals Inc. Antisense modulation of BCL-X expression
KR100768109B1 (ko) 1999-02-26 2007-10-17 더 유니버시티 오브 브리티쉬 콜롬비아 테스토스테론이 억제된 전립선 메시지-2의 안티센스치료방법
US6900187B2 (en) 1999-02-26 2005-05-31 The University Of British Columbia TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications
MXPA02006167A (es) 1999-12-21 2004-02-26 Univ Yale Promocion de la angiogenesis con survivina.
US20020132350A1 (en) 2000-09-14 2002-09-19 Pioneer Hi-Bred International, Inc. Targeted genetic manipulation using Mu bacteriophage cleaved donor complex
AU2003237616B2 (en) 2002-01-17 2007-07-05 The University Of British Columbia Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same

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Publication number Publication date
US20030166591A1 (en) 2003-09-04
EP1485401A1 (en) 2004-12-15
WO2003072591A1 (en) 2003-09-04
NZ534490A (en) 2006-05-26
CA2475433A1 (en) 2003-09-04
NO20043953L (no) 2004-11-19
HUP0500041A3 (en) 2008-09-29
US6900187B2 (en) 2005-05-31
AU2003213190A1 (en) 2003-09-09
JP2005530486A (ja) 2005-10-13
EP1485401A4 (en) 2007-08-01
HUP0500041A2 (hu) 2005-03-29

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