KR20040039351A - 서방 약물 전달 시스템으로 코팅된 스텐트 및 이의 용도 - Google Patents
서방 약물 전달 시스템으로 코팅된 스텐트 및 이의 용도 Download PDFInfo
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- KR20040039351A KR20040039351A KR10-2004-7003655A KR20047003655A KR20040039351A KR 20040039351 A KR20040039351 A KR 20040039351A KR 20047003655 A KR20047003655 A KR 20047003655A KR 20040039351 A KR20040039351 A KR 20040039351A
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- South Korea
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- medical device
- coating
- prodrug
- therapeutically active
- active form
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Landscapes
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US32242801P | 2001-09-17 | 2001-09-17 | |
US60/322,428 | 2001-09-17 | ||
US37276102P | 2002-04-15 | 2002-04-15 | |
US60/372,761 | 2002-04-15 | ||
PCT/US2002/029450 WO2003024455A2 (en) | 2001-09-17 | 2002-09-17 | Stent coated with a sustained-release drug delivery and method for use thereof |
Publications (1)
Publication Number | Publication Date |
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KR20040039351A true KR20040039351A (ko) | 2004-05-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR10-2004-7003655A KR20040039351A (ko) | 2001-09-17 | 2002-09-17 | 서방 약물 전달 시스템으로 코팅된 스텐트 및 이의 용도 |
Country Status (9)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009116750A2 (ko) * | 2008-03-17 | 2009-09-24 | 이화여자대학교 산학협력단 | 혈관 재협착방지 스텐트 코팅용 조성물 및 이를 이용해 제조된 스텐트 |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
AU767526B2 (en) | 1999-04-26 | 2003-11-13 | Gmp Vision Solutions, Inc. | Trabeculotomy device and method for treating glaucoma |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US7013182B1 (en) * | 2000-05-04 | 2006-03-14 | Cardiac Pacemakers, Inc. | Conductive polymer sheath on defibrillator shocking coils |
US7682648B1 (en) | 2000-05-31 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for forming polymeric coatings on stents |
US6613753B2 (en) * | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
EP1977724A1 (en) | 2001-04-07 | 2008-10-08 | Glaukos Corporation | System for treating ocular disorders |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
BR0209198A (pt) * | 2001-04-26 | 2004-06-08 | Control Delivery Sys Inc | Métodos de sìntese de compostos contendo fenol |
US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
GB0113697D0 (en) * | 2001-06-06 | 2001-07-25 | Smith & Nephew | Fixation devices for tissue repair |
AU2002345328A1 (en) | 2001-06-27 | 2003-03-03 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
IN2014DN10834A (US20050142162A1-20050630-C00074.png) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
US20030229390A1 (en) * | 2001-09-17 | 2003-12-11 | Control Delivery Systems, Inc. | On-stent delivery of pyrimidines and purine analogs |
WO2003060142A2 (en) * | 2001-10-18 | 2003-07-24 | Essentia Biosystems, Inc. | Compositions and methods for controlled release |
JP2005513050A (ja) * | 2001-12-10 | 2005-05-12 | コントロール・デリバリー・システムズ・インコーポレイテッド | 尿生殖路疾患の治療 |
US20030171812A1 (en) * | 2001-12-31 | 2003-09-11 | Ilan Grunberg | Minimally invasive modular support implant device and method |
US20030147813A1 (en) * | 2002-02-07 | 2003-08-07 | John Lyons | Method for treating chronic myelogenous leukemia |
US6998391B2 (en) * | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
CN100341589C (zh) * | 2002-05-24 | 2007-10-10 | 血管技术国际股份公司 | 用于涂覆医用植入物的组合物和方法 |
US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
US6982253B2 (en) * | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
CA2494188A1 (en) * | 2002-08-13 | 2004-02-19 | Medtronic, Inc. | Active agent delivery system including a hydrophobic cellulose derivative |
ATE459380T1 (de) * | 2002-08-13 | 2010-03-15 | Medtronic Inc | Darreichungssysteme von wirkstoffen mit poly(ethylene-co(meth)akrylate, medizinische vorrichtung und verfahren |
US20040086569A1 (en) * | 2002-08-13 | 2004-05-06 | Medtronic, Inc. | Active agent delivery systems, medical devices, and methods |
JP2006500088A (ja) * | 2002-08-13 | 2006-01-05 | メドトロニック・インコーポレーテッド | ポリマーの被覆及び支持体間の改良された付着を示す医用デバイス |
AU2003265446A1 (en) * | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
DE10244847A1 (de) * | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
IL152278A0 (en) * | 2002-10-14 | 2003-05-29 | Expandis Ltd | Minimally invasive support implant device and method |
US20040162263A1 (en) * | 2002-10-31 | 2004-08-19 | Supergen, Inc., A Delaware Corporation | Pharmaceutical formulations targeting specific regions of the gastrointesinal tract |
US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US8435550B2 (en) | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US7758881B2 (en) * | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US20060002968A1 (en) * | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
BRPI0407142A (pt) | 2003-02-14 | 2006-01-10 | Depuy Spine Inc | Dispositivo de fusão intervertebral formado in situ |
US7288609B1 (en) * | 2003-03-04 | 2007-10-30 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices based on poly (orthoesters) |
IL155146A0 (en) * | 2003-03-30 | 2003-10-31 | Expandis Ltd | Minimally invasive distraction device and method |
WO2004108792A2 (en) * | 2003-04-10 | 2004-12-16 | Vinod Chintamani Malshe | Novel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof |
EP1633403A2 (en) * | 2003-05-21 | 2006-03-15 | Control Delivery Systems, Inc. | Codrugs of diclofenac |
US20040236414A1 (en) * | 2003-05-23 | 2004-11-25 | Brar Balbir S. | Devices and methods for treatment of stenotic regions |
WO2005009480A2 (en) * | 2003-06-11 | 2005-02-03 | Control Delivery Systems, Inc. | Implants containing codrugs |
US20050037992A1 (en) * | 2003-07-22 | 2005-02-17 | John Lyons | Composition and method for treating neurological disorders |
US20050064038A1 (en) * | 2003-08-13 | 2005-03-24 | Dinh Thomas Q. | Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods |
CA2535345A1 (en) * | 2003-08-13 | 2005-03-03 | Medtronic, Inc. | Active agent delivery systems including a miscible polymer blend, medical devices, and methods |
US20050059682A1 (en) * | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
US20050209664A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Electrical devices and anti-scarring agents |
AU2004293030A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Electrical devices and anti-scarring agents |
US8998973B2 (en) | 2004-03-02 | 2015-04-07 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8992592B2 (en) | 2004-12-29 | 2015-03-31 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8591568B2 (en) | 2004-03-02 | 2013-11-26 | Boston Scientific Scimed, Inc. | Medical devices including metallic films and methods for making same |
US8632580B2 (en) | 2004-12-29 | 2014-01-21 | Boston Scientific Scimed, Inc. | Flexible medical devices including metallic films |
US7901447B2 (en) | 2004-12-29 | 2011-03-08 | Boston Scientific Scimed, Inc. | Medical devices including a metallic film and at least one filament |
US8709469B2 (en) | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
WO2006078320A2 (en) | 2004-08-04 | 2006-07-27 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
US9801982B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Implantable barrier device |
US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US8263102B2 (en) | 2004-09-28 | 2012-09-11 | Atrium Medical Corporation | Drug delivery coating for use with a stent |
US9801913B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Barrier layer |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US20060085065A1 (en) * | 2004-10-15 | 2006-04-20 | Krause Arthur A | Stent with auxiliary treatment structure |
US20060128654A1 (en) * | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of cytidine analogs and derivatives |
US20060128653A1 (en) * | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of decitabine |
US7250416B2 (en) * | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
WO2006119018A2 (en) * | 2005-04-29 | 2006-11-09 | Atrium Medical Corporation | Drug delivery coating for use with a medical device and methods of treating vascular injury |
US7854760B2 (en) * | 2005-05-16 | 2010-12-21 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
ATE489052T1 (de) * | 2005-05-18 | 2010-12-15 | Gt Urological Llc | Wirkstoffeluierung für implantierbare inkontinenzgeräte |
US7736293B2 (en) * | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
EP2705809B1 (en) | 2005-08-16 | 2016-03-23 | Benvenue Medical, Inc. | Spinal tissue distraction devices |
US8591583B2 (en) | 2005-08-16 | 2013-11-26 | Benvenue Medical, Inc. | Devices for treating the spine |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
EP1984036B1 (en) * | 2005-08-25 | 2010-06-30 | Medtronic Vascular Inc. | 4-aza-caprolactone-based polymeric compositions useful for the manufacture of biodegradable medical devices and as medical device coatings |
US20070048350A1 (en) * | 2005-08-31 | 2007-03-01 | Robert Falotico | Antithrombotic coating for drug eluting medical devices |
US20070051531A1 (en) * | 2005-09-08 | 2007-03-08 | Harshad Borgaonkar | Drug eluting coatings for a medical lead and method therefor |
US9278161B2 (en) * | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
JP5137841B2 (ja) | 2005-10-13 | 2013-02-06 | シンセス ゲーエムベーハー | 薬物含浸容器 |
CA2626030A1 (en) | 2005-10-15 | 2007-04-26 | Atrium Medical Corporation | Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings |
US20070123539A1 (en) * | 2005-10-20 | 2007-05-31 | University Of South Florida | Treatment of Restenosis and Stenosis with Dasatinib |
US8784860B2 (en) * | 2005-10-27 | 2014-07-22 | Cordis Corporation | Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease |
US20070117776A1 (en) * | 2005-11-04 | 2007-05-24 | John Lyons | Low Dose Therapy Of DNA Methylation Inhibitors |
US20070105792A1 (en) * | 2005-11-04 | 2007-05-10 | Dimartino Jorge F | Administration Of DNA Methylation Inhibitors For Treating Epigenetic Diseases |
EP1951332A1 (en) * | 2005-11-10 | 2008-08-06 | Schering Aktiengesellschaft | Reduction of restenosis |
US20070128242A1 (en) * | 2005-12-01 | 2007-06-07 | Zhao Jonathan Z | Polymeric compositions for controlled release or delivery of pharmacologically active agents |
US20070156230A1 (en) | 2006-01-04 | 2007-07-05 | Dugan Stephen R | Stents with radiopaque markers |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8025915B2 (en) * | 2006-01-11 | 2011-09-27 | Schott Ag | Method of preparing a macromolecule deterrent surface on a pharmaceutical package |
US20070168021A1 (en) * | 2006-01-17 | 2007-07-19 | Holmes David R Jr | Porous three dimensional nest scaffolding |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US7601383B2 (en) * | 2006-02-28 | 2009-10-13 | Advanced Cardiovascular Systems, Inc. | Coating construct containing poly (vinyl alcohol) |
US20070231363A1 (en) * | 2006-03-29 | 2007-10-04 | Yung-Ming Chen | Coatings formed from stimulus-sensitive material |
US7881808B2 (en) * | 2006-03-29 | 2011-02-01 | Cardiac Pacemakers, Inc. | Conductive polymeric coating with optional biobeneficial topcoat for a medical lead |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
WO2007127488A1 (en) * | 2006-04-27 | 2007-11-08 | Shenoy Narmada R | Compositions and methods for treating or preventing diseases of body passageways |
US7709045B2 (en) * | 2006-04-28 | 2010-05-04 | Boston Scientific Scimed, Inc. | Medical devices coated with porous carbon and methods of manufacturing the same |
US20070254003A1 (en) * | 2006-05-01 | 2007-11-01 | Pu Zhou | Non-sticky coatings with therapeutic agents for medical devices |
US8752268B2 (en) | 2006-05-26 | 2014-06-17 | Abbott Cardiovascular Systems Inc. | Method of making stents with radiopaque markers |
US8703167B2 (en) * | 2006-06-05 | 2014-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
US8128688B2 (en) | 2006-06-27 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Carbon coating on an implantable device |
US9265865B2 (en) * | 2006-06-30 | 2016-02-23 | Boston Scientific Scimed, Inc. | Stent having time-release indicator |
US7823263B2 (en) | 2006-07-11 | 2010-11-02 | Abbott Cardiovascular Systems Inc. | Method of removing stent islands from a stent |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
US8052743B2 (en) | 2006-08-02 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
EP2959925B1 (en) | 2006-09-15 | 2018-08-29 | Boston Scientific Limited | Medical devices and methods of making the same |
JP2010503494A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生分解性内部人工器官およびその製造方法 |
CA2663250A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
EP2210625B8 (en) * | 2006-09-15 | 2012-02-29 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
CA2663762A1 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US8066750B2 (en) | 2006-10-06 | 2011-11-29 | Warsaw Orthopedic, Inc | Port structures for non-rigid bone plates |
US9492596B2 (en) | 2006-11-06 | 2016-11-15 | Atrium Medical Corporation | Barrier layer with underlying medical device and one or more reinforcing support structures |
WO2008057344A2 (en) | 2006-11-06 | 2008-05-15 | Atrium Medical Corporation | Coated surgical mesh |
US8506515B2 (en) | 2006-11-10 | 2013-08-13 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
US8668703B2 (en) * | 2006-12-01 | 2014-03-11 | Wake Forest University Health Sciences | Medical devices incorporating collagen inhibitors |
WO2008070863A2 (en) | 2006-12-07 | 2008-06-12 | Interventional Spine, Inc. | Intervertebral implant |
US8147539B2 (en) * | 2006-12-20 | 2012-04-03 | Boston Scientific Scimed, Inc. | Stent with a coating for delivering a therapeutic agent |
ES2506144T3 (es) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Endoprótesis bioerosionables y procedimiento de fabricación de las mismas |
US20080172124A1 (en) * | 2007-01-11 | 2008-07-17 | Robert Lamar Bjork | Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention |
US9339593B2 (en) * | 2007-01-11 | 2016-05-17 | Robert L. Bjork, JR. | Drug-eluting coronary artery stent coated with anti-platelet-derived growth factor antibodies overlaying extracellular matrix proteins with an outer coating of anti-inflammatory (calcineurin inhibitor) and/or anti-proliferatives |
CA2678006C (en) * | 2007-02-21 | 2014-10-14 | Benvenue Medical, Inc. | Devices for treating the spine |
US8900307B2 (en) | 2007-06-26 | 2014-12-02 | DePuy Synthes Products, LLC | Highly lordosed fusion cage |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7955381B1 (en) | 2007-06-29 | 2011-06-07 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical device with different types of bioceramic particles |
EP2182798B1 (en) | 2007-07-16 | 2020-11-18 | Allvivo Vascular, Inc. | Antimicrobial constructs |
US20090043330A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Embolic protection devices and methods |
US20090043380A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Coatings for promoting endothelization of medical devices |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US20090112239A1 (en) * | 2007-10-31 | 2009-04-30 | Specialized Vascular Technologies, Inc. | Sticky dilatation balloon and methods of using |
US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
EP2222281B1 (en) | 2007-12-20 | 2018-12-05 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
EP2237748B1 (en) | 2008-01-17 | 2012-09-05 | Synthes GmbH | An expandable intervertebral implant |
NZ600649A (en) * | 2008-02-22 | 2013-12-20 | Angiotech Int Ag | Anti-infective device comprising a catheter and an anti-infective composition |
US7981106B2 (en) * | 2008-02-26 | 2011-07-19 | Pinchas Gilad | Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals |
CA2720580A1 (en) | 2008-04-05 | 2009-10-08 | Synthes Usa, Llc | Expandable intervertebral implant |
US8883768B2 (en) * | 2008-04-18 | 2014-11-11 | Warsaw Orthopedic, Inc. | Fluocinolone implants to protect against undesirable bone and cartilage destruction |
GR1006552B (el) * | 2008-04-24 | 2009-10-02 | Νικολαος Χρηστου Δημοφιλος | Ενδοπροστατικο ελατηριο-δοκιδα-βελονα/εγχυση/ενεσιμη μεθοδος |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
DE102008002397A1 (de) * | 2008-06-12 | 2009-12-17 | Biotronik Vi Patent Ag | Implantierbare Vorrichtung |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
US8076529B2 (en) | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
US8226603B2 (en) | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
US8049061B2 (en) * | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
WO2010054121A2 (en) * | 2008-11-07 | 2010-05-14 | Specialized Vascular Technologies, Inc. | Extracellular matrix modulating coatings for medical devices |
EP3670561B1 (en) | 2009-01-12 | 2023-12-06 | University Of Massachusetts Lowell | Polyisobutylene-based polyurethanes |
US20130268062A1 (en) | 2012-04-05 | 2013-10-10 | Zeus Industrial Products, Inc. | Composite prosthetic devices |
US8267992B2 (en) | 2009-03-02 | 2012-09-18 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US9526620B2 (en) | 2009-03-30 | 2016-12-27 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US9254350B2 (en) * | 2009-04-10 | 2016-02-09 | Medtronic Vascular, Inc. | Implantable medical devices having bioabsorbable primer polymer coatings |
US9078712B2 (en) | 2009-04-15 | 2015-07-14 | Warsaw Orthopedic, Inc. | Preformed drug-eluting device to be affixed to an anterior spinal plate |
US9414864B2 (en) | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
US8992601B2 (en) | 2009-05-20 | 2015-03-31 | 480 Biomedical, Inc. | Medical implants |
US20110319987A1 (en) | 2009-05-20 | 2011-12-29 | Arsenal Medical | Medical implant |
US8888840B2 (en) * | 2009-05-20 | 2014-11-18 | Boston Scientific Scimed, Inc. | Drug eluting medical implant |
US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
US9309347B2 (en) | 2009-05-20 | 2016-04-12 | Biomedical, Inc. | Bioresorbable thermoset polyester/urethane elastomers |
CA2762811C (en) | 2009-05-20 | 2023-03-21 | Arsenal Medical, Inc. | Self-expandable medical device comprising polymeric strands and coatings thereon |
JP5456892B2 (ja) | 2009-08-07 | 2014-04-02 | ゼウス インダストリアル プロダクツ インコーポレイテッド | 多層複合体 |
US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
US8529934B2 (en) | 2009-08-21 | 2013-09-10 | Boston Scientific Scimed, Inc. | Crosslinkable polyisobutylene-based polymers and medical devices containing the same |
US8644952B2 (en) | 2009-09-02 | 2014-02-04 | Cardiac Pacemakers, Inc. | Medical devices including polyisobutylene based polymers and derivatives thereof |
US8374704B2 (en) | 2009-09-02 | 2013-02-12 | Cardiac Pacemakers, Inc. | Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same |
US8753708B2 (en) * | 2009-09-02 | 2014-06-17 | Cardiac Pacemakers, Inc. | Solventless method for forming a coating on a medical electrical lead body |
US8372133B2 (en) | 2009-10-05 | 2013-02-12 | 480 Biomedical, Inc. | Polymeric implant delivery system |
WO2011044533A2 (en) | 2009-10-09 | 2011-04-14 | Specialized Vascular Technologies, Inc. | Coating system and method for drug elution management |
US9393129B2 (en) | 2009-12-10 | 2016-07-19 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
WO2011119536A1 (en) | 2010-03-22 | 2011-09-29 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8696738B2 (en) | 2010-05-20 | 2014-04-15 | Maquet Cardiovascular Llc | Composite prosthesis with external polymeric support structure and methods of manufacturing the same |
US9282979B2 (en) | 2010-06-24 | 2016-03-15 | DePuy Synthes Products, Inc. | Instruments and methods for non-parallel disc space preparation |
US8979860B2 (en) | 2010-06-24 | 2015-03-17 | DePuy Synthes Products. LLC | Enhanced cage insertion device |
JP5850930B2 (ja) | 2010-06-29 | 2016-02-03 | ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 離反椎間インプラント |
WO2012009707A2 (en) | 2010-07-16 | 2012-01-19 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
US9402732B2 (en) | 2010-10-11 | 2016-08-02 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
CN102058450B (zh) * | 2010-11-26 | 2012-07-18 | 哈尔滨工业大学 | 一种用于血管破裂修复的超疏水血管支架的制备方法 |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
WO2012178018A2 (en) | 2011-06-24 | 2012-12-27 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
LT2750768T (lt) | 2011-08-30 | 2019-02-11 | Astex Pharmaceuticals, Inc. | Decitabino darinio kompozicijos |
TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
EP2819741B1 (en) * | 2012-02-27 | 2018-03-28 | O-Ray Pharma, Inc. | Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders |
EP2830553B1 (en) | 2012-03-26 | 2017-12-27 | Glaukos Corporation | Apparatus for delivering multiple ocular implants |
US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
CN104520345B (zh) | 2012-11-21 | 2017-10-03 | 马萨诸塞州大学 | 高强度聚氨异丁烯聚氨甲酸酯 |
US9119606B2 (en) | 2013-01-21 | 2015-09-01 | Ethicon, Inc. | Sealant delivery device for anastomotic stapler |
US9717601B2 (en) | 2013-02-28 | 2017-08-01 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US9522070B2 (en) | 2013-03-07 | 2016-12-20 | Interventional Spine, Inc. | Intervertebral implant |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
WO2014186435A2 (en) * | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
US20160144067A1 (en) | 2013-06-21 | 2016-05-26 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
DE102013214636A1 (de) | 2013-07-26 | 2015-01-29 | Heraeus Medical Gmbh | Bioresorbierbare Werkstoffverbunde, enthaltend Magnesium und Magnesiumlegierungen sowie Implantate aus diesen Verbunden |
EP3148491B1 (en) | 2014-05-29 | 2020-07-01 | Glaukos Corporation | Implants with controlled drug delivery features and manufacturing method for said implants |
US20160121027A1 (en) | 2014-10-23 | 2016-05-05 | South Dakota Board Of Regents | Formulations for Tailored Drug Release |
GR1008697B (el) * | 2014-12-05 | 2016-02-25 | Rontis Hellas Α.Ε.Β.Ε., | Συσκευη που εκλυει φαρμακευτικη ουσια |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US9700443B2 (en) | 2015-06-12 | 2017-07-11 | Abbott Cardiovascular Systems Inc. | Methods for attaching a radiopaque marker to a scaffold |
US10219894B2 (en) | 2015-06-29 | 2019-03-05 | 480 Biomedical, Inc. | Implantable scaffolds for treatment of sinusitis |
US10232082B2 (en) | 2015-06-29 | 2019-03-19 | 480 Biomedical, Inc. | Implantable scaffolds for treatment of sinusitis |
AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
CA2998170C (en) | 2015-09-15 | 2023-10-03 | Savage Medical, Inc. | Devices and methods for anchoring a sheath in a tissue cavity |
WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
AU2016339794B2 (en) * | 2015-10-13 | 2021-07-08 | Venarum Medical, Llc | Implantable valve and method |
EP3442479A1 (en) | 2016-04-20 | 2019-02-20 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
CN109688980B (zh) | 2016-06-28 | 2022-06-10 | Eit 新兴移植技术股份有限公司 | 具有关节运动接头的可扩张和角度可调节的椎间笼 |
JP6995789B2 (ja) | 2016-06-28 | 2022-01-17 | イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー | 拡張可能かつ角度調節可能な椎間ケージ |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
EP3592786B1 (en) | 2017-03-07 | 2023-05-10 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
US10398563B2 (en) | 2017-05-08 | 2019-09-03 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
MX2020001233A (es) | 2017-08-03 | 2020-07-20 | Otsuka Pharma Co Ltd | Compuesto farmaceutico y metodos de purificacion del mismo. |
WO2019036544A1 (en) | 2017-08-17 | 2019-02-21 | Cardiac Pacemakers, Inc. | PHOTORÉTICULATED POLYMERS FOR IMPROVED DURABILITY |
US11116625B2 (en) | 2017-09-28 | 2021-09-14 | Glaukos Corporation | Apparatus and method for controlling placement of intraocular implants |
US11472911B2 (en) | 2018-01-17 | 2022-10-18 | Cardiac Pacemakers, Inc. | End-capped polyisobutylene polyurethane |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
CN114699563B (zh) * | 2022-02-22 | 2024-02-02 | 中国医科大学附属盛京医院 | 一种负载型聚醚型聚氨酯薄膜、制备方法及其应用 |
US12090064B2 (en) | 2022-03-01 | 2024-09-17 | Medos International Sarl | Stabilization members for expandable intervertebral implants, and related systems and methods |
WO2023229767A1 (en) * | 2022-05-24 | 2023-11-30 | Cardioforma Llc | Percutaneous endovascular centrifugal heart pump and method |
CN115444991A (zh) * | 2022-09-08 | 2022-12-09 | 沈阳贺麒医疗科技合伙企业(有限合伙) | 负载药物的基体及其制备方法 |
CN115671408A (zh) * | 2022-10-29 | 2023-02-03 | 金傅(北京)医疗科技有限公司 | 一种能够避免肉芽组织增生的物质 |
CN115671409A (zh) * | 2022-10-29 | 2023-02-03 | 金傅(北京)医疗科技有限公司 | 一种能够防止肉芽组织增生的加药方法及药物 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
GB1509979A (en) * | 1975-11-28 | 1978-05-10 | Fisons Ltd | Pharmaceutical compositions containing aspirin or indomethacin |
US4300557A (en) * | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
US4309996A (en) * | 1980-04-28 | 1982-01-12 | Alza Corporation | System with microporous releasing diffusor |
US4309776A (en) * | 1980-05-13 | 1982-01-12 | Ramon Berguer | Intravascular implantation device and method of using the same |
WO1983000150A1 (en) * | 1981-07-02 | 1983-01-20 | Walton, Alan, G. | Glycosaminoglycan drug complexes |
GB8403138D0 (en) * | 1984-02-07 | 1984-03-14 | Graham N B | Sustained release of active ingredient |
US4588525A (en) * | 1984-02-27 | 1986-05-13 | Molecular Biosystems, Inc. | Prodrug compounds for dermal application |
US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
GB8507779D0 (en) * | 1985-03-26 | 1985-05-01 | Fujisawa Pharmaceutical Co | Drug carrier |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US4911707A (en) * | 1987-02-13 | 1990-03-27 | Ciba-Geigy Corporation | Monolithic user-activated transdermal therapeutic system |
US5057301A (en) * | 1988-04-06 | 1991-10-15 | Neorx Corporation | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents |
US4923699A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Eye treatment suspension |
US5194581A (en) * | 1989-03-09 | 1993-03-16 | Leong Kam W | Biodegradable poly(phosphoesters) |
US5439688A (en) * | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
CH679207A5 (US20050142162A1-20050630-C00074.png) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
DE69110787T2 (de) * | 1990-02-28 | 1996-04-04 | Medtronic, Inc., Minneapolis, Minn. | Intraluminale prothese mit wirkstoffeluierung. |
US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
US5130126A (en) * | 1990-07-09 | 1992-07-14 | Nippon Oil & Fats Co., Ltd. | Polymer-drug conjugate and a method of producing it |
EP0492903A1 (en) * | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma |
US5104877A (en) * | 1991-02-25 | 1992-04-14 | Abbott Laboratories | Psoriasis treatment |
US5176907A (en) * | 1991-08-13 | 1993-01-05 | The Johns Hopkins University School Of Medicine | Biocompatible and biodegradable poly (phosphoester-urethanes) |
WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5716981A (en) * | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
CA2178592C (en) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Long-acting injection suspensions and a process for their preparation |
US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
ATE267798T1 (de) * | 1994-01-28 | 2004-06-15 | Univ Kentucky Res Found | Kombinierte wirkstoffe als methode zur gezielten wirkstoff-freisetzung |
DE29624503U1 (de) | 1995-04-19 | 2004-09-16 | Boston Scientific Scimed, Inc. | Arzneimittel-freisetzender beschichteter Stent |
US5569429A (en) * | 1995-05-05 | 1996-10-29 | Randcastle Extrusion Systems, Inc. | Dynamic seal and sealing method |
JPH11510837A (ja) * | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US6240616B1 (en) * | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US5843172A (en) * | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
WO1998056425A1 (en) * | 1997-06-11 | 1998-12-17 | The School Of Pharmacy, University Of London | Pharmaceutical compositions containing antibody-enzyme conjugates in combination with prodrugs |
US6159488A (en) * | 1997-08-14 | 2000-12-12 | Agricultural Research Org. Ministry Of Agriculture (Gov.) | Intracoronary stents containing quinazolinone derivatives |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
JP2001520979A (ja) * | 1997-10-27 | 2001-11-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 網膜傷の閉鎖のための方法及び医薬組成物 |
US5976169A (en) * | 1997-12-16 | 1999-11-02 | Cardiovasc, Inc. | Stent with silver coating and method |
US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US20030049689A1 (en) * | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
BR0209198A (pt) * | 2001-04-26 | 2004-06-08 | Control Delivery Sys Inc | Métodos de sìntese de compostos contendo fenol |
US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
AR034362A1 (es) * | 2001-06-05 | 2004-02-18 | Control Delivery Systems | Compuestos analgesicos de liberacion prolongada |
US6787179B2 (en) * | 2001-06-29 | 2004-09-07 | Ethicon, Inc. | Sterilization of bioactive coatings |
IN2014DN10834A (US20050142162A1-20050630-C00074.png) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
WO2003043657A1 (en) * | 2001-11-19 | 2003-05-30 | Control Delivery Systems, Inc. | Topical delivery of codrugs |
-
2002
- 2002-04-26 IN IN10834DEN2014 patent/IN2014DN10834A/en unknown
- 2002-09-17 JP JP2003528551A patent/JP2005523045A/ja not_active Withdrawn
- 2002-09-17 EP EP02778269A patent/EP1429774A2/en not_active Withdrawn
- 2002-09-17 AU AU2002339938A patent/AU2002339938B2/en not_active Ceased
- 2002-09-17 KR KR10-2004-7003655A patent/KR20040039351A/ko not_active Application Discontinuation
- 2002-09-17 CN CN028228448A patent/CN1589166B/zh not_active Expired - Fee Related
- 2002-09-17 CA CA2460920A patent/CA2460920C/en not_active Expired - Fee Related
- 2002-09-17 US US10/245,840 patent/US7279175B2/en not_active Expired - Lifetime
- 2002-09-17 WO PCT/US2002/029450 patent/WO2003024455A2/en active Application Filing
-
2007
- 2007-10-02 US US11/906,765 patent/US20080161907A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009116750A2 (ko) * | 2008-03-17 | 2009-09-24 | 이화여자대학교 산학협력단 | 혈관 재협착방지 스텐트 코팅용 조성물 및 이를 이용해 제조된 스텐트 |
WO2009116750A3 (ko) * | 2008-03-17 | 2009-12-17 | 이화여자대학교 산학협력단 | 혈관 재협착방지 스텐트 코팅용 조성물 및 이를 이용해 제조된 스텐트 |
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CA2460920C (en) | 2011-01-04 |
CA2460920A1 (en) | 2003-03-27 |
US20030108588A1 (en) | 2003-06-12 |
WO2003024455A2 (en) | 2003-03-27 |
IN2014DN10834A (US20050142162A1-20050630-C00074.png) | 2015-09-04 |
CN1589166A (zh) | 2005-03-02 |
AU2002339938B2 (en) | 2008-04-17 |
US7279175B2 (en) | 2007-10-09 |
WO2003024455A8 (en) | 2008-12-18 |
EP1429774A2 (en) | 2004-06-23 |
US20080161907A1 (en) | 2008-07-03 |
CN1589166B (zh) | 2010-06-23 |
WO2003024455A3 (en) | 2003-10-30 |
JP2005523045A (ja) | 2005-08-04 |
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