KR20040026273A - The health-supporting food being effective the dementia and its preparation method - Google Patents

Abstract

PURPOSE: A method for manufacturing a health supplementary food by mixing deep sea water, organic germanium and an extract of Polygoni multiflori Radix, Aurantii Fructus, Ponciri Fructus, Zingiberis Rhizoma, Curcumae Tuber, Poria cocos, Lophatheri Herba or the like is provided. The manufactured food product is effective for the treatment and prevention of dementia. CONSTITUTION: About 60 to 74.5% by weight of purified deep sea water is mixed with 25 to 39.5% by weight of a herbal extract and 0.5 to 15% by weight of organic germanium(Ge-132). The herbal extract is obtained from Polygoni multiflori Radix, Aurantii Fructus, Ponciri Fructus, Zingiberis Rhizoma, Curcumae Tuber, Poria cocos, Lophatheri Herba, silkworm powder, Gastrodiae Rhizoma and Acori Graminei Rhizoma.

Description

The health-supporting food being effective the dementia and its preparation method

The present invention relates to a dietary supplement and a method for producing the same, which are excellent in treating and preventing dementia, based on purified deep water (freshness solution), organic germanium (Ge-132), and herbal medicines. 60 to 74.5% by weight of purified deep water (lead solution), sewage, dermis, tangerine, ginger, turmeric, bokyeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo and 600m deep water and 1400m deep water. The present invention relates to a health supplement having excellent therapeutic and preventive effects on dementia, and a method for manufacturing the same, comprising 25 to 39.5 wt% of herbal extracts composed of licorice and 0.5 to 15 wt% of organic germanium (Ge-132). .

Dementia is a marked decline in mental abilities such as intelligence, will, and memory. Like mental retardation, dementia is a disorder of intelligence, and mental retardation is mainly due to late or stopped development of intelligence. Normal intelligence is degraded due to cerebral diseases. Typical of dementia is widespread damage of cerebral nerve cells and is called dementia. Others include elderly dementia, progressive paralysis caused by syphilis, or epilepsy dementia caused by repeated epileptic seizures.

Impaired memory and understanding, poor computational ability, poor poverty of thought, and the tendency of retaliation, a phenomenon in which the impulse to realize a constant behavior persists and repeats the same behavior. Instability of emotions and emotional incontinence, which can be difficult to control, can also be seen. Mature emotionality is also violated. Of course, mental vision becomes narrower, and dementia deepens into animal life. At first glance, schizophrenia looks like dementia at first glance, and individual basic intelligence is often well maintained, but dementia is indistinguishable from dementia or dementia.

It does not appear when the damage to the cerebral region is localized, but local microscopic symptoms corresponding to the site, ie, spontaneous lack of frontal lobe, motility aspiration, personality change, execution of parietal lobe, and perception ), Visual laryngeal lobe, and temporal lobe sensory laryngeal lobe.

Geriatric dementia is an age-related mental disorder that results from degenerative changes in the brain due to aging. It is mainly caused by the deterioration of intelligence. There is no phenomenal clear distinction about the transition to physiological senility.

The senile changes can be seen in the frontal lobe, especially in the frontal lobe, with significant brain atrophy. Histologically, neuronal degeneration, increased ribovstin in neurons, the appearance of senile plaques, and neurofibrillary tangles. Thickening of 纖維, and the symptoms include severe forgetfulness and memory impairment, resulting in embarrassment or perception to mitigate such disorders. In the world, woojeung (迂 遠 症) or ambition (warning) that precedes the military sound appears, the judgment or reasoning power is lowered, the productive thinking is lost, the calculation power is deteriorated, and the judgment on the situation becomes impossible. Symptoms of back.

Emotional instability is evident, irritating and prone to excitement, sometimes repulsive, skeptical, and delusional. Stubborn, angry, self-centered, and subtle personality changes become apparent.

In terms of behavior, the behavior caused by inadequate adaptation without temperance is remarkable, laziness and impurity appear in the absence of inactivity, and as a disease type, single dementia and delirium There are forms, reticular forms, etc. There is no definite treatment.

Geriatric dementia is caused by deterioration of the body and various stimulating factors outside the body during the deterioration of the human body.The causes are wounds, living alone, economic pressure, social isolation or loneliness, mental shock, cerebral arteriosclerosis, cerebral hemorrhage, Cerebral anemia and the like.

In particular, the causes of oriental medicine are Guhe, Heo Hui, Deepening Stars (心火 亢 盛), Blood Fish (간), Ganxin Hui, Shenbi Yang (양), Ganul Yanghang (肝鬱 陽 亢), Water purification (精髓) deficiency, schizophrenia (심) Shimgyu (心 竅) has many causes.

Chinese medicines are mainly used for the conscience body medicine to help the debilitated body and spirit, and the spirit medicine stop medicine to relax the mind and mind. Acupuncture treatments and additional treatments are also combined, and acupuncture treatments are also used.

In addition, he puts on the Yumiji Yellow Tang and Palmiji Yellow Tang, which show the nutrition and function of the brain in the direction to protect the liver, and to give energy to the head and to enhance the energy. Ikgi-tang, Kyungokgo, Sukjeondaebotang, Ssanghwa-tang, left ear, right ear, etc. may be added to or prescribed the medicine.

On the other hand, deep water (leading liquid) refers to seawater at a depth of 1,000 m or less from the oceanic point of view, and does not generate organic matter by photosynthesis, is excellent in decomposition and reaches the vertical mixing of seawater in winter. It is a seawater that is below the depth of the seawater, and its composition varies according to the depth of seawater, and it is very clean water because it is hardly affected by chemical, biological hazards and environmental pollution, and large water molecules with high physical safety are typically It is aggregated into aggregates and is formed at low temperature, and contains not only a large amount of trace elements and minerals, but also inorganic nutritional salts, so that water eutrophication is not only used as a health drink, but also fresh products, food, Maintains the freshness of living tissue (organs) and promotes the vitality of the skin surface It is known that until the unit protection.

In particular, it is used for the production of functional bottled water and cosmetics, and it is used for fisheries such as seaweed culture and fish breeding, fertilization of fisheries, seedling production, food development such as cosmetics, bottled water, soap, salt, seasoning, medicine development, agriculture and industrial fields. In Japan, pier, miso, sake, pickled side dishes, and sports drinks made with deep water are popular and popular.

However, many studies on deep water (leading fluid) have not been carried out yet, so the application to various uses is insignificant, and there have been no cases of application for the treatment and prevention of dementia.

In addition, there are many medicines that are applied to various symptoms based on various clinical experiences, but there are few examples that are professionally applied to dementia, and clinical formulations are applied according to simple symptoms.

Germanium with an atomic number of 32 and atomic weight of 72.59 is a nonmetallic element and is also contained in soil and plants.Korean ginseng contains 4,189ppm, garlic 754ppm, wolfberry 124ppm, comfrey 152ppm, and 257ppm of wild boil. The results show that all of the anticancer effects that differ from existing anticancer drugs are due to the germanium's incredible enrichment of oxygen in vivo and its role as an interferon derivative.

The living body can be said to be an aggregate of ultrafine particles of electricity depending on the viewpoint. Each engine and each part function as a unique aggregate. Therefore, each part has a defined potential, and the distorted potential is a disease. An electroencephalogram or an electrocardiogram is a device for detecting a disorder by measuring a change in the potential, and germanium plays an amazing role in correcting the distorted potential.

For example, looking at the potential of cancer cells is quite different from the potential of other normal cells. Since cancer cells continue to proliferate at a violent rate, the potential is high and severely deformed, but germanium takes electrons away from the cancer cells with the high potential and lowers the potential, thereby stopping the activity of abnormal cells (cancer cells) in progress. It is also the reason for preventing cancer metastasis.

Germanium, as well as blood, each cell has the characteristics of a semiconductor, semiconductors can not coexist in terms of their electronic properties, so there is no risk of excess germanium accumulate in the body, no matter how much, even long-term administration Extra germanium is also excreted, which means there are no side effects.

Recently, as interest in organic germanium has increased, its excellent efficacy is recognized, and it is highly regarded as a functional healing substance, and it is highly regarded as a lung cancer, bladder cancer, breast cancer, neurosis, asthma, heart failure, sinusitis, neuralgia, leukemia, cerebral malaise, uterine fibroids. In all diseases, including cirrhosis and cirrhosis, germanium has an amazing effect.

In particular, we humans eat food in order to live, but what is not absorbed is excreted in feces, but what is absorbed in the digestive system is burned in the body by oxygen through various processes, and finally, it is excreted in the body as carbon dioxide and water, That is, gaseous carbon is combined with oxygen and comes out of the body by exhalation as carbon dioxide gas. Another gas, hydrogen ions, is combined with oxygen and excreted in sweat or urine with water, but hydrogen is a cation and is completely useless in vivo. In addition, the higher the amount of hydrogen, the greater the amount of oxygen required for neutralization. In this case, germanium is administered in combination with hydrogen instead of oxygen. Therefore, oxygen is not wasted in the body. It will play the necessary role.

However, although the efficacy of such germanium is known, it has not been reported that synergistic effects on the treatment and prevention of dementia are exhibited in combination with deep water.

Accordingly, an object of the present invention is to provide a dietary supplement showing excellent therapeutic and preventive effects on dementia as well as efficacy as a dietary supplement based on purified deep water (freshness solution), organic germanium (Ge-132) and herbal medicine as a main ingredient. There is.

Another object of the present invention to provide a method for easily preparing a health supplement of the above object.

In order to achieve not only the above-mentioned objects but also other objects that can be easily expressed, in the present invention, 60 to 74.5% by weight of purified deep water (leading liquid), which is mixed at an appropriate ratio by purifying deep water of 600 m and deep water of 1400 m, It is composed of 25 ~ 39.5% by weight of herbal extracts consisting of sewage, dermis, tangerine, ginger, turmeric, fuyeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo and licorice, and 0.5-15% by weight of organic germanium (Ge-132). Purified deep water (preparative solution), herbal medicine extract and organic germanium (Ge-132) was mixed to obtain the health supplement of the present invention, and by taking it to obtain an excellent treatment and preventive effect on dementia.

The present invention is described in more detail as follows.

Health supplement food having excellent treatment and preventive effect on dementia according to the present invention 60 to 74.5% by weight of purified deep water (leading solution), purified by mixing the depth of the seabed 600 m deep water and 1400 m deep water in the appropriate ratio, sewage, dermis, It is characterized by consisting of 25 ~ 39.5% by weight of Chinese herbal extracts consisting of tangerberry, ginger, turmeric, Fuling, bamboo leaf, cheonma, silkworm powder, Seokchangpo and licorice and 0.5 to 15% by weight of organic germanium (Ge-132).

In addition, the manufacturing method of the health supplement food effective for the treatment and prevention of dementia according to the present invention is purified by mixing the depth of the seabed 600m deep water and 1400m deep water in an appropriate ratio and then sewage, dermis, tangerine, ginger, turmeric, After extracting the extract from the herbal medicine consisting of Bokryeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo and licorice, and purified it, characterized in that homogeneous mixing of the purified deep water (freshening liquid), herbal extract and organic germanium (Ge-132) It is erased.

The components of the deep sea water of 600m and the deep seawater of 1400m used in the present invention are shown in Table 1 below.

TABLE 1

As can be seen from Table 1 above, the deep water (leading liquid) contains various inorganic substances and trace elements in a large amount, and in the present invention, the deep water of 600 m and the deep water of 1400 m are mixed at a ratio of 1: 3 to 3: 1. Was used.

It is preferable to use a depth of 600m deep water and 1400m deep water, but it is possible to use both deep water of 600m or more deep sea water, and the depth water (leading liquid) contains a large amount of trace elements and minerals as well as inorganic nutrient salts. Because it contains water nutrient nutrients, it maintains the freshness of living tissues (organs), and it is effective and maintains the balance of the human body to heal the cause of dementia. The thing refine | purified by the method of filtering after standing still for 1-2 days, removing a deposit, maintaining the temperature of -4-0 degreeC is used.

The amount of deep water (leading liquid) is preferably 60 to 74.5% by weight, and when the amount is less than 60% by weight, excellent treatment and prevention effects on dementia are not satisfactory, and when it exceeds 74.5% by weight, it is effective as a dietary supplement. This has the disadvantage of deteriorating.

Organic germanium (Ge-132) is very important for its purity and safety, and its digestion and absorption in the body is also very important. So, it is used by dissolving it in deep water (leading liquid), and the state of powder is pure white. No matter the same, flour is fine, powder is not agglomerated like agglomerate, and it should be used without any impurities.Add 20mg of organic germanium powder to 50cc of water at 60 ~ 80 ℃ (more accurate distillation surface) and stir. It is completely soluble in water, and no sediment (impurity) should be formed after a long time after dissolution. After being completely dissolved in water, the water is selected to be clearer and more transparent than ordinary water like crystal.

The oxygen contained in organo germanium is released into the generator oxygen in the cell. Normally, oxygen exists in the form of molecule O ₂ in a normal state, but when combined with other substances, it becomes in the form of oxygen atom O, and organo germanium is generator oxygen. It releases to the cells just before death and activates the intracellular chemical reaction called metabolic activity, and the cells regain their original function and work freshly. As a result, the condition of the whole body improves and the etiology of dementia is improved. To be removed.

The base of the acid is not oxygen, but hydrogen, more precisely hydrogen ions, and hydrogen ions are nothing but useful gases in the body, but when they accumulate more than that, the constitution is said to be acidified. Oxygen is needed to clean up this unnecessary gas, and oxygen combines with hydrogen ions, which are not needed, to form neutral water and be excreted out of the body. Organic germanium acts to supply oxygen for it, accompanied by harmful heavy metals such as mercury and cadmium. It acts to excrete outside the body.

In the present invention, it is isolated from edible plants containing germanium in a high unit such as mushrooms, Korean ginseng, chestnuts, goji berries, etc., mushrooms such as garlic, comfrey, aloe, shiitake mushrooms can also be used as a source of organic germanium (Ge-132) And "carboxy ethyl germanium 32 oxide" (molecular formula: (GeCH ₂ CH ₂ COOH) ₂ O ₃ ) is particularly effective.

The amount of organic germanium (Ge-132) is preferably 0.5 to 15% by weight, and when the amount is less than 0.5% by weight, the effect of organic germanium (Ge-132) is weakly expressed. If exceeded, there is a disadvantage in that the synergistic effect of addition is weak and not economical.

Meanwhile, Chinese herbal medicine uses sewage, dermis, tanza fruit, ginger, turmeric, bokyeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo and licorice, which are known to be effective in the treatment and prevention of dementia. After filtration is effective, the use of the herbal medicine is preferably 25 to 39.5% by weight, when the amount is less than 25% by weight, there is a disadvantage in the expression of efficacy as a dietary supplement, when it exceeds 39.5% by weight As the amount of deep water (leading liquid) and organic germanium (Ge-132) is relatively reduced, it has a weak treatment and preventive effect on dementia.

In particular, sewage is known to be effective in preventing aging by supplementing the renal blood of the kidneys and liver, and dermis and tanberry fruit improve digestion and remove waste products from the body. Ginger is toxic of various drugs. It is effective in removing turbidity, turmeric clears turbid blood and increases brain blood flow, and clears the mind. It is known to have a therapeutic effect.

In addition, Chunma and silkworm powder have the effect of treating forgetfulness, consciousness disorder, nervous breakdown and convulsive disease, and Seokchangpo has the function to clear the block and penetrate the blockage, and to treat mental confusion and memory loss, licorice. At the same time, it replenishes qi and detoxifies and harmonizes the medicinal herbs.

The dietary supplement of the present invention, although the mechanism of action is not exactly known, by improving the cerebral blood flow improves the various functions of neurons that are degraded in the brain, by promoting the synthesis of cholinergic neurotransmitters to improve memory and cognitive function It is believed to have an excellent effect on the treatment and prevention of dementia.

The following examples illustrate the invention in more detail, but do not limit the scope of the invention.

Example 1

Take 600m deep water and 1400m deep water and leave it for 1 day while maintaining the temperature of -4 ~ 0 ℃, remove the precipitate, and then purify by filtering. Then, 600m deep water and 1400m deep water is 1: 1 ratio. Mix with.

Separately, 15 g of sewage, dermis, tangerberry, ginger, turmeric, bokyeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo and licorice were added to hot water, extracted with hot water for 6 hours, cooled to room temperature and allowed to stand for 1 day. Prepare herbal extracts by removing them.

Then, 68% by weight of the deep water mixture (preliminary solution), 30% by weight of the herbal extract and 2% by weight of the carboxyethyl germanium 32 oxide are mixed and stirred to completely dissolve the vegetable carboxyethyl germanium 32 oxide, and the components are homogeneously It was mixed to prepare a dietary supplement effective for the treatment and prevention of dementia of the present invention.

Experimental Example 1

In order to prove the non-toxicity of the health food according to the present invention to the human body, an acute toxicity test was conducted in mice.

[Acute Toxicity Test]

(1) materials and methods

A) Experimental animal

1) Species: ICR mouse

2) Gender and age at acquisition: Male 4 weeks

3) Reason for selection: Since the ICR mice used in this experiment have been widely used in toxicology tests all over the world, it is rich in basic physiological, anatomical and toxicological data, so it is advantageous to compare the results. Selected for ease of use.

4) Source: Continental Test Animal

5) Quarantine and Purification Period: The laboratory was allowed to purify for about 1 week. During the period, general symptoms were observed and healthy animals were used for the test.

6) Weight range and age at intravenous injection: 20 ± 3g, 5 weeks

7) Number of animals: 100 (including preliminary test)

8) Group Separation and Animal Time: The weights of healthy animals used for the test were divided into groups so that the average weight of each group was almost identical. The individual identification was performed by the method of marking pigmented pigment (picrinic acid) and TAG by breeding box. Was used.

B) animal room

1) Temperature and humidity range: temperature 22 ± 2 ℃, relative humidity 53 ± 2%

2) Contrast cycle: Fluorescent lighting (09:00 to 18:00 off)

3) Roughness: 150 ~ 300Lux

4) Types of breeding box: Polycarbonate cage for mouse during purifying, quarantine, administration and observation period (manufactured by Daejong Machinery)

5) Number of animals per breeding box: Purified, quarantine period-5

Dosing period-5

C) feed

1) Type: Solid feed for laboratory animals

2) Source: Samyang Oil Feed Co., Ltd.

D) negative

1) Type: filtered tap water

E) test substance

1) Sample: The composition prepared in Example 1 (1000-fold dilution)

Blank test amount (negative control)

F) Method of administration

1) Route of administration: Oral administration (Oral)

2) Number of administration and period of administration: 1 administration

3) Administration site and administration method: The mice were orally administered.

4) Administration time: 10: 00 ~ 12: 00

5) Dosage: 50ml / kg was administered immediately based on body weight.

(2) Test method

A) It was conducted in accordance with the National Institutes of Health toxicity test.

B) Clinical symptoms observation: All animals were conducted daily.

Six hours after the administration was observed every hour, and carefully observed the mobility, appearance and autonomic symptoms once daily for 5 days thereafter.

(3) Test result

TABLE 2

Acute Toxicity Test Results

As can be seen from the above results, two weeks after oral administration of the health supplement food and the negative control group of the present invention, body weight and motility were observed to be normal.

Experimental Example 2

The test was conducted under the following conditions using 11-week-old Wister rats (males). The breeding method through the trial period changed the feed with the same environment. As a common food, this was prepared by applying a 20% casein expression adjusted so that rat growth was not hindered. The feeding method was to consume 15 g every four hours on a daily basis using the speside fidding method. In addition, water was allowed to be ingested freely.

For the onset of memory impairment, ivothenic acid (IBOTENIC ACID, manufactured by Sigma) was dissolved in physiological saline buffer and 30 nmol / ml ivothenic acid solution was used.

After anesthetizing the rat, the brain is fixed and inserted into the mid-brain nucleus (A53, LO, O, OH,%, according to the Konig Klipped brain coverage) of the rat brain with a micro syringe. Inject over minutes. In order to prevent reflux, the rat was allowed to stand for 5 minutes and then the microsyringe was removed to allow the rat to develop memory impairment.

A learning task was used as a learning test, and as a task, the evacuation site was installed with a diameter of 120cm and a height of 40cm and water of 21 degrees up to 25cm in depth and a 10cm × 10cm surface at a position of 1cm below the surface of the water.

On the water surface, granulated foamed styropol was floated and the evacuation site of the rat was not visible. The circumference of the tank took 4 points of east, west, north and south and divided the water surface into 4 parts. In the vicinity of the device, there were objects such as tester and lighting fluorescent lamp, which were not visually touched to the rat, and the rat was well visible in the water tank which was not visually touched.

In the training session, rats were placed in the tank, and the test was conducted once until they arrived at the evacuation site, and four times a day at least 10 minutes apart.

The memory test was conducted to remove the evacuation site according to the condition of the rice paddy, and to keep the rats in the tank for 60 minutes and to stay at the zoned place at the evacuation site.

The same test was repeated in the above method for rats that were not infused with ibothenic acid to prepare for the rats that caused memory impairment. Twenty rats each were used for this. These rats were reared for 17 days only with common food. The camping training was conducted in a gown for 17 days at intervals of 3 days on 14th and 16th days. On the 17th day, the verification test of the record holding power was conducted.

The results are shown in Table 3.

TABLE 3

In addition, the standard values indicate that the rats stayed in the evacuation area for 20 rats each, and the larger the value, the better the memory retention. From Table 3, it was confirmed that memory impairment caused by ivoteic acid occurred.

Forty rats showing the onset of memory impairment were prepared, and feeding was conducted by dividing 20 rats from the following two groups by weight.

Feed 1 g of the dietary supplement of Example 1 in 14.2 g of common A group food, and use a solution (3.5 μg / ml) of vitamin B ₁₂ (cyanocobalamin) dissolved in distilled water per 1 kg of rat body weight. 25 μg of vitamin B ₁₂ was administered.

Only B group was given common food.

TABLE 4

As can be seen from Table 4, the health supplement of the present invention improved memory retention.

As described above, in the present invention, 60 to 74.5% by weight of purified deep water (freshening solution) mixed with an appropriate ratio of purified deep water of 600m and deep water of 1400m, sewage, dermis, tangerine, ginger, turmeric, bokyeong, bamboo leaf , 25 ~ 39.5% by weight of herbal medicine extract consisting of cheonma, silkworm powder, changchangpo and licorice and 0.5 ~ 15% by weight of organic germanium (Ge-132), but purified deep water (leading liquid), herbal medicine extract and organic germanium ( Ge-132) to obtain a dietary supplement of the present invention by mixing, it was possible to obtain an excellent treatment and preventive effect on dementia.

Claims (1)

60 to 74.5% by weight of purified deep water (leading solution), purified from sea water 600m deep water and 1400m deep water, sewage, dermis, tangerine, ginger, turmeric, bokyeong, bamboo leaf, cheonma, silkworm powder, Seokchangpo And 25 to 39.5% by weight of the herb extract composed of licorice and 0.5 to 15% by weight of organic germanium (Ge-132).