KR20040003401A - Preparation and it's method of functional food for male sexual dysfunction - Google Patents

Abstract

PURPOSE: A functional food containing 7 kinds of herbs and gamma oryzanol, vitamin and minerals is provided. A method for manufacturing the same is also provided. The manufactured food has safety to the human body as well as excellent therapeutic effect in male sexual dysfunction. CONSTITUTION: A mixture of 10 to 20% by weight of Lycii Cortex Radicis, 5 to 10% by weight of Crataegi Fructus, 5 to 10% by weight of Rubi Fructus, 5 to 10% by weight of Schizandrae Fructus and 5 to 15% by weight of Eucommiae Cortex is extracted for 8hr at 100deg.C. The extract is concentrated and then dried. Thereafter, the powder is mixed with 1 to 5% by weight of Codonopsis pilosula, 2 to 5% by weight of Cervi Parvum Cornu and a suitable amount of gamma oryzanol, vitamin and minerals and encapsulated.

Description

Functional nutritional supplementary foods effective for male sexual dysfunction and preparation method thereof {Preparation and it's method of functional food for male sexual dysfunction}

The present invention relates to a method for producing a functional nutritional supplement food that can help sexual dysfunction, such as erectile dysfunction, premature ejaculation, by mixing natural substances such as wolfberry, mountain lion, bokbunja, Schisandra chinensis, antler, ginseng in a constant ratio .

Erectile dysfunction generally refers to erectile dysfunction, which is the sexually functional impotence of men. Erectile dysfunction is a condition in which a man who does not have enough strength to enter a woman's gate and / or enters a woman's gate does not maintain sufficient erectile state until the ejaculation due to strength and insufficient rigidity for vaginal insertion.

Erectile dysfunction means an impotence sufficient for sexual intercourse and an inability to maintain it. The penis is erected by the congestion of certain tissues (cavernous bodies) in the central part of the penis with blood. Although there are no accurate statistics on domestic erectile dysfunction patients, about 2 million men in the US have about 10 million to 12 million men between 18 and 75 years of age, and the majority are over 55 years old. have. Prevention of the disease is very important because of the increase in adult diseases such as diabetes, hypertension, stress, industrial accidents, drinking, smoking, etc.

Erectile dysfunction is caused by psychological disorders (psychopathic), physiological abnormalities (stromal), or a combination of both. Typically, many factors contribute to erectile dysfunction.

Psychogenic erectile dysfunction can occur in men who are psychologically anxious or in various neurotic disorders such as depression, schizophrenia, or personality disorder, and develop when they have misinformation about sexual function, unconscious guilt, or excessive attention only to entertain the person. It is known.

Important causes of organic erectile dysfunction include vascular dysfunction, neurologic dificienci and drug therapy. The primary cause of erectile dysfunction is during arterial failure and erection, which prevents the penis from turning to blood. Arterial insufficiency is primarily due to arteriosclerosis, which is caused by smoking, hyperlipidemia, chronic hypertension, diabetes, and coronary artery disease. If any one of these abnormalities occurs due to the multiplication of fibrous tissue anatomically, smooth muscle disease, collagen changes, etc., the vein occlusion function is disturbed and blood is not stored in the cavernous body. It is known to be.

In addition, endocrine disorders such as hypothalamic-pituitary-gonadal axis, hyperprolactinemia, thyroid, parasympathetic disease, and calcium metabolic abnormalities are also causes.

Until now, the erectile dysfunction treatment agent is prostaglandin E1, which is a carbject of American Upron, which is directly injected into the corpus cavernosum to relax the penis smooth muscle, causing erection. The method has side effects such as avoiding injections and penile tissue damage.

Muse of Janssen Co., Ltd. is a urethral injection erectile dysfunction treatment that is suppository and inserted only in the urethra. The urethral injection acts only on the penis. It quickly disappears and has fewer side effects such as headache, skin seizures, indigestion, constipation, while the pain and burning of the urethra can be felt. The disadvantage is that.

Viagra, a Pfizer company in the United States, is convenient for oral administration.It suppresses phosphodiesterase, which is involved in cGMP, and increases intracellular cGMP to maintain the erection of penile cavernous bodies. There is a high risk of death due to side effects for patients with myocardial infarction, stroke, and cardiovascular disease.

In addition, there are a number of herbal medicines, such as S-escrim recently, but a safe and easy to take formulation has not been introduced yet.

Therefore, the present invention has developed an effective formulation for sexual dysfunction easy to take without side effects and completed the present invention.

The purpose of the present invention is not only to have an excellent therapeutic effect against male sexual dysfunction, but also to develop a medicine that is known to be as stable to the human body as possible as a raw material, a natural substance, and easy to take by oral administration. To provide a male functional dysfunction functional food and a method of manufacturing the same that have no side effects.

The agent effective for male sexual dysfunction of the present invention is a capsule containing 7 kinds of herbal medicines of goji, hawthorn, bokbunja, Schisandra chinensis, antler ginseng, tofu and zinc gamma-orizanol and vitamin minerals.

Hereinafter, a detailed description of each herbal ingredient of the present invention.

Goji (Chinese matrimony vine) is the fruit of the Goji tree to brighten the eyes, keep young and are used as a medicine for longevity. Recent research results have been published in studies on the improvement of anticancer, anti-cancer, immune enhancing liver function and blood pressure lowering, and is a kind of herbal medicine used as a nourishing tonic to promote metabolism.

Sansa is a raspberry in Chinese medicine, which adds new spirits and benefits to urinate, tastes sweet, and complements women's condolences, helping women conceive and man's genitalia. It is a kind of herbal medicine that strengthens the liver and brightens the eyes.

Schizandra chinensis is a deciduous plant of the Magnoliaceae. Leaves are oval-shaped, long oval, with hairs on the leaf veins of the back, serrated at the edges, and round and ears. Schisandra chinensis is a combination of five flavors: sour, sweet, bitter, salty, and spicy. It is a kind of herbal medicine used for nourishment, tonic, expectoration, and thickening.

Deer antler is a horn of a deer that is dried in the shade. It is a kind of medicinal herb that is used for the increase of physical strength, the effect of increasing the immune system, and the weakness of Gi and blood.

Ginseng (人 생, codonopsis pilosule) is the root of perennial perilla belonging to the bellflower family called ginseng, also known as Dangsam Deodeok. Used as ginseng Daedong, it is mainly used to protect iron and is good for weak constitution. It is a kind of herbal medicine used for edible promotion, tonic and bowel.

Eucommia ulmoides is a larvae and plant with leaves oval, sharp in tip, with a lot of fine hairs, and used as a health tea. Bark is used as a medicine for tonics, tonics, stamina reduction, neuralgia, and hygropathy.

The method for producing a food for supplemental nutrition for male sexual dysfunction of the present invention is

Gojija 10-20% Sansa 5-10% Bokbunja 5-10% Schisandra chinensis 5-10% Tofu 5-15% After mixing for 12 hours at 100 ° C, the extracted solution was concentrated and concentrated to 50% solids. After drying powdered ginseng 1-5% deer antler 2-5% separately extracted at low temperature in alcohol and dried powder, and then the zinc oxide, vitamins, gamma olizanol was prepared by mixing the capsules.

The pharmacological test for the functional food constituting the present invention was measured by the relaxation effect of the corpus cavernosum smooth muscle, and the test was carried out as follows.

In the present invention, tissues were prepared using 15 New Zealand white male rabbits weighing 2.5 to 3.0 kg. Thiopental sodium (30 mg / kg) was injected into the rabbit ear vein, followed by anesthesia, and the whole penis was separated from the pelvic bone, and the cavernous tissue was separated from the surrounding white film. At this time, in order to prevent damage to the endothelium present in the cavernous body was not forced to manipulate the tissue. Two long tissue sections (1 × 2 × 7 mm) were obtained from the separated cavernous smooth muscle. Each section was secured at both ends using a 6-0 thread, and then one was connected to a ring connected to a transducer (Grass Research Polygraph, Model 79H, W, Warwick, Ri) for measuring tension, and the other organ. Fixed at the end of the bath. Avoid excessive pull to avoid damaging the endothelial tissue during fixation.

Sections of the corpus cavernosum tissue of white male rabbits were placed vertically in a 5 mL organ bath, and the tension in the tissues was recorded on the physicograph paper. The solution used was HEPES, the composition is NaCl 118mM, KCI 4.7mM, CaCe 2.5mM, MgCl2 2mM, NaHCO3, 25mM, glucose 10mM, HEPES 10mM, pH was adjusted to 7.4 using 1N NaOH. 100% oxygen was used during the experiment, and the temperature of the organ bath was set at 37 ° C.

The cavernous tissue was initially adjusted to a basic tension of 1 g, and then tested after waiting for about 60 minutes to stabilize. Every 15 minutes, the solution was changed to a saturated oxygen solution, and the basic tension was adjusted to 1 g until the experiment was started.

Changes in tension during the experiments were recorded on the physiographies. Drug administration was achieved by accumulating from low to high concentrations, and when the highest relaxation point was reached, administration of the next concentration of drug was achieved by accumulating from low concentration to high concentration, and when the highest relaxation point was reached. Concentration of drug was administered. After changing the perfusion solution (referring to the Hepes solution), when the new drug was administered, the patient waited about 5 to 10 minutes to stabilize the tissue.

1) Experiment Method

① New Zealand white male rabbits weighing 2.5-3 kg were reared at a temperature of 23 ± ℃ and a relative humidity of 55 ± 5% for 12 hours. Water and feed were provided for free intake.

② Put the rabbit on the stand and fix the limbs and head.

③ Inject rabbits with pentobarbitel sodim (30-50mg / kg) and let them die before carotid artery dissection.

④ Extract the penis and store it in hepes buffer tyroide solution at 37-38 ℃ immediately to prevent autostsis.

⑤ A smooth muscle slice (6mm × 2mm × 2mm) of the corpus cavernosum was produced using a microscope.

⑥ Fill the organ chawber with 37-38 ℃ hepes buffer tyroide solution and supply it with 95% oxygen and 5% carbon dioxide gas to keep the temperature in 37 ℃ hot water gun.

⑦ corpus cavernosum smooth muscle · vaginal connect the force transducer and phtsiography.

⑧ After the artificial contraction by the contractor (Norepinephrine), the experiment was carried out after confirming that there was no damage of the cavernous fragment by confirming that the relaxation reaction to the acetylcholine was observed.

⑨ Measure relaxation effect

end. Constriction is added to the corpus cavernosum smooth muscle and then administered.

I. When the tension in the contracted state with the shrinkage agent is 100, it is measured how many percent the tension is reduced.

2) Experiment result

(1) Relaxation effect on corpus cavernosum smooth muscle

(2) The test results show that the functional food of the present invention is effective in erectile dysfunction.

As described through the above experimental example, the present invention is effective for male sexual dysfunction and is a very useful invention for sexual hypersensitivity sexual life industry.

Claims (1)

Composition of functional nutrition supplements effective for male sexual dysfunction, including gojija, hawthorn, bokbunja, schisandra, antler, ginseng and gamma omizanol, zinc oxide, vitamins B2, B6