KR20040000046A - The health-supporting food being effective the atopic dermatitis and its preparation method - Google Patents
The health-supporting food being effective the atopic dermatitis and its preparation method Download PDFInfo
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- KR20040000046A KR20040000046A KR1020020034427A KR20020034427A KR20040000046A KR 20040000046 A KR20040000046 A KR 20040000046A KR 1020020034427 A KR1020020034427 A KR 1020020034427A KR 20020034427 A KR20020034427 A KR 20020034427A KR 20040000046 A KR20040000046 A KR 20040000046A
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- dietary supplement
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- licorice
- peony
- rhubarb
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- B60N2/00—Seats specially adapted for vehicles; Arrangement or mounting of seats in vehicles
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- A—HUMAN NECESSITIES
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- A47C7/748—Adaptations for incorporating lamps, radio sets, bars, telephones, ventilation, heating or cooling arrangements or the like for ventilation, heating or cooling for heating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60N—SEATS SPECIALLY ADAPTED FOR VEHICLES; VEHICLE PASSENGER ACCOMMODATION NOT OTHERWISE PROVIDED FOR
- B60N2/00—Seats specially adapted for vehicles; Arrangement or mounting of seats in vehicles
- B60N2/58—Seat coverings
- B60N2/5891—Seat coverings characterised by the manufacturing process; manufacturing seat coverings not otherwise provided for
Abstract
Description
본 발명은 정제된 심층수(선도액), 유기 게르마늄(Ge-132) 및 한약재를 주재료로 하여 아토피성 피부염에 유용한 효과를 나타내는 건강보조식품 및 이의 제조방법에 관한 것으로, 좀 더 구체적으로는 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 정제된 심층수 60 ∼ 74.5중량%, 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재 추출물 25 ∼ 39.5중량% 및 유기 게르마늄 0.5 ∼ 15중량%로 구성되는 것을 특징으로 하는 아토피성 피부염에 효과적인 건강보조식품 및 이의 제조방법에 관한 것이다.The present invention relates to a dietary supplement and a method for preparing the same, which are useful for atopic dermatitis, based on purified deep water (freshness solution), organic germanium (Ge-132), and herbal medicines. 60 ~ 74.5% by weight of purified deep water and 1400m deep water of purified and mixed in an appropriate ratio, salvia, red ginseng, rhyme, baekrye, righteous, mountain medicine, Hyunsam, Keumgeum, golden, licorice, raw sulfur, Angelica, red peony, baekseonpi , Thick, Bupyeong, dermis, Shouo, Ogapi, red ginseng, allies, roaring, poisonous, white paper, seshin, abandonment, rhubarb, Count, silver, rhubarb, creation, short skin, silver, rhubarb, tea, red spirit, taxi, wood, It consists of 25 to 39.5% by weight of at least five kinds of Chinese herbal medicine extracts selected from the group consisting of gypsum, horse riding, hair, bamboo leaf, mokyang, talan, gold and silver, pogongyoung, bokbokyeong, branch father, windproof and 0.5-15% by weight of organic germanium Characterized by The present invention relates to a dietary supplement and a method of preparing the same for atopic dermatitis.
일반적으로 아토피(Atopy)란 그리스어가 어원으로 "비정상적인 반응", "기묘한", "뜻을 알 수 없다"라는 의미로서 어원 그대로 아토피성 피부염이란 다양한 원인이 복잡하게 뒤엉켜 발병하고 완화와 재발을 반복하며, 치료가 어렵운 피부질환이다.In general, atopy is a Greek word that means "abnormal response", "weird", or "unknown." As it is, atopy dermatitis is a complex cause of various causes of atopic dermatitis. It is a skin disease that is difficult to treat.
아토피는 아토피 소인을 가지고 있는 개인에서 피부, 호흡기 점막, 안점막, 장잠막 등에 나타나는 일련의 알레르기 증상을 말하며, 이러한 아토피 소인(알레르기 체질)은 유전되어 가족적으로 나타나며, 아토피 소인에 의한 알레르기 질환으로 알레르기 피부염, 알레르기성비염, 천식, 알레르기성 결막염, 아토피성 두드러기 등이 있으며, 이들 질환은 단독 또는 여러 질환이 동시에 나타날 수 있다.Atopy refers to a series of allergic symptoms that appear in the skin, respiratory mucosa, eye mucosa, and intestinal mucosa in individuals with atopic predisposition. These atopic predispositions (allergic constitutions) are inherited and appear to be family. Dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, atopic urticaria and the like, these diseases may be present alone or several diseases at the same time.
아토피 피부염(Atopic dermatitis)은 아토피 알레르기를 가진 사람에서 나타나는 대표적인 피부질환으로, 흔히, 태열이라고 불리는 만성피부질환으로서 피부건조증 및 가려움증이 주증상이며, 면역학적 특성을 보여 다른 알레르기 질환인 두드러기, 금속 알레르기, 천식이나 알레르기성 비염 등을 동반하는 경우가 있고, 가족적인 경향이 있다.Atopic dermatitis is a typical skin disease in people with atopic dermatitis. It is a chronic skin disease commonly referred to as febrile fever. Skin dryness and itching are the main symptoms and other allergic diseases such as urticaria and metal allergy. , Asthma and allergic rhinitis are sometimes accompanied and tend to be family.
아토피 피부염은 상당히 많은 사람들이 앓고 있는데 전 인구의 0.5% - 1%, 어린이의 경우 5 - 10%가 고통을 받고 있고, 증상이 나타나는 시기는 대체로 생후 2 ∼ 6개월이며, 특히 1세 미만에서 가장 많이 나타나고 85%가 만 다섯 살 안에 나타난다. 보통 어릴 때 잠시 앓는 병이라고 알려져 있으나 환자의 50%는 두 돌 이내에 없어지나 25%는 청소년기까지 가며, 나머지 25%는 성인이 되어도 없어지지 않고 계속된다.Atopic dermatitis suffers from a significant number of people, with 0.5% to 1% of the population and 5 to 10% of children suffering from symptoms, usually occurring at 2 to 6 months of age, especially under 1 year old. Many appear and 85% appear within five years of age. It is commonly known as a disease when young, but 50% of patients disappear within two stones, but 25% go to adolescence, and the remaining 25% do not go away even as adults.
우리의 몸은 소화, 영양, 호흡, 순환, 배설 등의 내부적인 부분과 외부의 이물질에 대한 방어기능이 조화롭게 이루어져야 하지만 인체 내부와 외부의 기능이 동시에 이상이 발생하거나 균형을 잃어버리게 되면 아토피가 발생하게 된다.Our body should be in harmony with internal functions such as digestion, nutrition, breathing, circulation, and excretion, and defense against foreign substances, but atopy occurs when abnormal function or loss of balance occurs at the same time. Done.
즉, 아토피피부염에서 면역이상은 면역글로부린(IgE)이 인체내의 혈관주위나 피부에 있는 비만세포의 표면에 붙어 있다가 재차 항원이 인체에 침투하면 면역글로부린과 결합하여 비만세포를 활성화시켜 히스타민 등 화학물질을 분비시키고,이러한 화학물질이 혈관과 피부를 자극하여 피부에 붉은 반점과 부종, 가려움증을 일으키고 아토피피부염을 유발, 악화시키게 된다.In other words, in atopic dermatitis, immunodeficiency is caused by immunoglobulin (IgE) attached to the surface of mast cells in the periphery or skin of the human body, and when the antigen penetrates into the human body again, it binds to immunoglobulin and activates mast cells such as histamine and other chemicals. They secrete substances, and these chemicals irritate blood vessels and skin, causing red spots, swelling and itching on the skin, causing and worsening atopic dermatitis.
아토피 피부염 환자는 피부가 건조해지는 경향이 있어 여름에는 피부의 땀구멍이 잘 열리지 않아 땀을 배출시킬수 없어 땀띠가 잘 생기고, 겨울에는 피부에 습기가 부족하여 건조해지고 거칠어진다.Patients with atopic dermatitis tend to dry the skin, so in the summer, the pores of the skin do not open well, so the sweat can not be discharged, and the sweat band is good, and in winter, the skin lacks moisture and becomes dry and rough.
이러한 아토피 피부염을 치료하는 방법으로는 스테로이드제나 항히스타민제 또는 항생제 등을 사용하는 방법이 대부분이지만 원인은 그대로 방치한 상태로 투여되기 때문에 부작용이나 약물의 의존성이 생기는 단점이 있을 뿐만 아니라 효과적이지 못한 것으로 알려지고 있다.Most of the methods used to treat atopic dermatitis include steroids, antihistamines, or antibiotics, but they are not effective because they are left untreated and cause side effects or drug dependence. ought.
최근에는 많은 식이요법이나 한방요법이 개발되고 있지만, 그 효과가 만족스럽지 못하여 실제로는 적용에 한계가 있는 실정이다.Recently, many diets and herbal therapies have been developed, but the effects are not satisfactory, and in reality, there is a limit to the application.
한편, 심층수란 해양학적 관점에서 볼 때 해저 200m 이하의 깊이에 있는 바닷물을 의미하며, 광합성에 의한 유기물 생성이 일어나지 않고 분해가 탁월하며 겨울철 해수 수직 혼합(海水垂直混合)작용이 도달하는 심도(深度)의 이하에 있는 해수로서 바닷물의 깊이에 따라 성분이 다르고, 화학적, 생물학적 위험 및 환경오염등에 영향을 거의 받지 않아 대단히 깨끗한 물이며, 전형적으로 높은 물리적 안전성을 가진 대단위의 물분자들이 집합체로 뭉쳐져서 낮은 온도에서 형성되어지고, 대량의 미량원소와 미네랄 등을 포함하고 있을 뿐만 아니라 무기영양소금이 포함되어 있어 물부영양화 현상이 뚜렷하여 건강음료로서 사용되어 질 뿐만 아니라 신선한 제품, 음식, 살아있는 조직(장기)의 신선도를 유지시켜주고 피부 표면의 활력을 증진시키는 피부 보호 기능까지 하는 것으로 알려지고 있다.On the other hand, from the oceanic point of view, deep water means seawater at a depth of 200m or less below sea level, and organic matter generation by photosynthesis does not occur, the decomposition is excellent, and the depth of water reaching the vertical mixing of seawater in winter. Seawater below) is very clean according to the depth of the seawater and is hardly affected by chemical, biological hazards and environmental pollution. Typically, a large number of water molecules with high physical safety are clustered together. It is formed at low temperature, contains a large amount of trace elements and minerals, and also contains inorganic nutrient salts, so that water eutrophication is not only used as a health drink, but also fresh products, food, and living tissues (long-term Protects the skin's freshness and vitality of the skin's surface It is said to function.
특히, 기능성 생수 제조나 화장품 생산에 활용되고, 해조류 배양 및 어류사육, 어장 비옥화, 종묘생산 등 수산분야와 화장품, 생수, 비누, 소금, 조미료 등 식품 개발, 의약품 개발, 농업 및 공업분야 등에 활용이 기대되고, 일본에서는 심층수를 사용해 만든 부두, 된장, 청주, 절인 반찬, 스포츠 드링크 등이 출시되어 호평을 받고 있다.In particular, it is used for the production of functional bottled water and cosmetics, and it is used for fisheries such as seaweed culture and fish breeding, fertilization of fisheries, seedling production, food development such as cosmetics, bottled water, soap, salt, seasoning, medicine development, agriculture and industrial fields. In Japan, pier, miso, sake, pickled side dishes, and sports drinks are popular in Japan.
그러나, 지금까지는 심층수에 대한 많은 연구는 있었으나, 다양한 용도로의 적용이 미미한 상황이고, 아토피성 피부염의 치료에 적용된 사례는 전무한 실정이다.However, until now, there have been many studies on deep water, but the application to a variety of applications is insignificant, and there have been no cases of application to the treatment of atopic dermatitis.
또한, 한약재들은 다양한 임상 경험을 토대로 하여 다양한 증상에 적용되는 많은 약재들이 있으나, 대부분은 열수추출하여 복용하는 형태로 이용되고 있으며, 외피용 약제로의 개발은 극히 미미한 실정이고, 특히, 아토피성 피부염에 적용되는 예는 거의 없었다.In addition, there are many medicines that are applied to various symptoms based on various clinical experiences, but most of them are used in the form of taking hot water extract, and the development of the skin medicine is very minimal, in particular, atopic dermatitis Few examples have been applied to.
그리고, 원자번호 32, 원자량 72.59의 게르마늄은 금속아닌 아금속 원소로 흙속이나 식물에도 함유되어 있으며, 한국 인삼에는 4,189ppm, 마늘 754ppm, 구기자 124ppm, 컴프리 152ppm, 산두근 257ppm이 함유되어 있는데, 게르마늄이 현존하는 항암제와는 다른 차원의 제암효과가 있는 것은 모두가 게르마늄이 지닌 생체내에서 산소를 놀랍도록 풍부하게 해주는 작용과 인터페론 유도체로서의 역할 때문임이 연구 결과 밝혀졌다.Germanium with an atomic number of 32 and atomic weight of 72.59 is a nonmetallic element and is also contained in soil and plants.Korean ginseng contains 4,189ppm, garlic 754ppm, wolfberry 124ppm, comfrey 152ppm, and 257ppm of wild boil. The results show that all of the anticancer effects that differ from existing anticancer drugs are due to the germanium's incredible enrichment of oxygen in vivo and its role as an interferon derivative.
생체란 보는 관점에 따라서는 전기의 극초미립자의 응집체라고 할 수 있다. 각 기관, 각 부분은 각각 고유의 응집체로서 기능하고 있다. 때문에 각 부분은 정해진 전위가 있고, 그 전위가 뒤틀린 것이 질병이며, 뇌파측정기나 심전도는 이 전위의 변화를 측정함으로써 장애를 찾아내는 기기이고, 이 뒤틀린 전위를 바로 잡는데 게르마늄이 놀라운 역할을 한다.The living body can be said to be an aggregate of ultrafine particles of electricity depending on the viewpoint. Each engine and each part function as a unique aggregate. Therefore, each part has a defined potential, and the distorted potential is a disease. An electroencephalogram or an electrocardiogram is a device for detecting a disorder by measuring a change in the potential, and germanium plays an amazing role in correcting the distorted potential.
예를 들어, 암세포의 전위를 살펴보면 다른 정상세포의 전위와는 판이하게 다르다. 암세포는 맹렬한 속도로 세포증식을 계속하기 때문에 그 전위가 높고 심하게 격변하고 있지만 게르마늄은 그 높은 전위를 지닌 암세포로부터 전자를 빼앗아 전위를 낮추는 작용을 하므로서 진행중인 이상세포(암세포)의 활동을 중지시키는 역할을 하며, 암의 전이를 막는 이유이기도 하다.For example, looking at the potential of cancer cells is quite different from the potential of other normal cells. Because cancer cells continue to proliferate at a violent rate, the potential is high and severely deformed, but germanium takes the electrons away from the cancer cells with the high potential and lowers the potential, thereby stopping the activity of abnormal cells (cancer cells) in progress. It is also the reason for preventing cancer metastasis.
게르마늄은 물론 혈액을 비롯한 각 세포는 반도체의 성질을 지니고 있는데 반도체끼리는 그 전자물성으로 보아 공존할 수 없기 때문에 여분의 게르마늄이 체내에 축적될 우려가 전혀 없으며 축적될 수 없다는것은 아무리 많이, 장기간 투여해도 여분의 게르마늄은 배설되기 때문에 부작용이 없다는 뜻이기도 하다.Germanium, as well as blood, each cell has the characteristics of a semiconductor, semiconductors can not coexist in terms of their electronic properties, so there is no risk of excess germanium accumulate in the body, no matter how much, even long-term administration Extra germanium is also excreted, which means there are no side effects.
최근 유기(有機) 게르마늄에 대한 관심이 높아지면서 그의 뛰어난 효능이 인정됨에 따라 기능성 치유물질로 높은 평가받고 있으며, 폐암, 방광암, 유암, 노이로제, 천식, 당뇨병, 고혈압증, 심부전, 축농증, 신경통, 백혈병, 뇌연화증, 자궁근종, 간경병 등 모든 병에서 게르마늄은 놀라운 효과를 나타내고 있다.Recently, as interest in organic germanium increases, its excellent efficacy is recognized, and thus it is highly regarded as a functional healing substance, and it is highly regarded as lung cancer, bladder cancer, cancer, neurosis, asthma, diabetes, hypertension, heart failure, sinusitis, neuralgia, leukemia Germanium has an amazing effect in all diseases, such as cerebral malacia, uterine fibroids and cirrhosis.
특히, 우리들 인간은 살아가기 위해서 음식물을 먹는데, 흡수되지 않은 것은 대변으로 배설되지만 소화기관에서 흡수된 것은 여러가지 과정을 거쳐 산소에 의해 체내에서 연소되며, 최후로 탄산가스와 물이 되어 체외로 배설, 즉, 가스상태의 탄소는 산소와 결합되어 탄산가스로서 호기에 의해 몸 밖으로 나오며, 또 하나의 가스인 수소이온은 산소와 결합되어 물로 땀이나 소변으로 배설되지만 수소는 양이온으로 생체내에서는 전혀 쓸모가 없으며 수소량이 많을수록 중화에 필요한 산소의 양도 많이 요구되므로 이런 경우 게르마늄을 투여하면 산소 대신 수소와 결합하여 배설되기 때문에 몸안의 산소가 낭비됨이 없이 기능회복, 세포수복등 본래의 역할, 건강에 절대적으로 필요한 역할을 하게 되는 것이다.In particular, we humans eat food in order to live, but what is not absorbed is excreted in feces, but what is absorbed in the digestive system is burned in the body by oxygen through various processes, and finally, it is excreted in the body as carbon dioxide and water, That is, gaseous carbon is combined with oxygen and comes out of the body by exhalation as carbon dioxide gas. Another gas, hydrogen ions, is combined with oxygen and excreted in sweat or urine with water, but hydrogen is a cation and is completely useless in vivo. In addition, the higher the amount of hydrogen, the greater the amount of oxygen required for neutralization. In this case, germanium is administered in combination with hydrogen instead of oxygen. Therefore, oxygen is not wasted in the body. It will play the necessary role.
그러나, 이와 같은 게르마늄의 효능이 알려졌음에도 불구하고 아직까지 아토피성 피부염에 게르마늄이 적용된 예는 보고된 바 없다.However, even though the effects of germanium have been known, no examples of germanium applied to atopic dermatitis have been reported.
따라서, 본 발명의 목적은 정제된 심층수(선도액), 유기 게르마늄(Ge-132) 및 한약재를 주재료로 하여 건강보조식품으로서의 효능 뿐만 아니라 아토피성 피부염에 유용한 효과를 나타내는 건강보조식품을 제공하는 데 있다.Accordingly, an object of the present invention is to provide a dietary supplement that shows useful effects on atopic dermatitis as well as efficacy as a dietary supplement, using the purified deep water (preparative solution), organic germanium (Ge-132) and herbal medicine as a main ingredient. have.
본 발명의 다른 목적은 상기 목적의 건강보조식품을 용이하게 제조하는 방법을 제공하는 데 있다.Another object of the present invention to provide a method for easily preparing a health supplement of the above object.
상술한 목적들 뿐만 아니라 용이하게 표출될수 있는 또 다른 목적들을 달성하기 위하여 본 발명에서는 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 정제된 심층수 60 ∼ 74.5중량%, 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재 추출물 25 ∼ 39.5중량% 및 유기 게르마늄 0.5 ∼ 15중량%로 구성되어지되 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 다음에 별도로 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재를 추출한 후, 정제된 심층수, 한약재 추출물 및 유기 게르마늄을 혼합하여 본 발명의 건강보조식품을 얻고, 이를 복용하므로서 건강보조식품으로서의 효능을 얻는 것은 물론 아토피성 피부염을 용이하게 치료할 수 있었다.In order to achieve not only the above-mentioned objects but also other objects that can be easily expressed, the present invention purifies deep water of 600 m and deep water of 1400 m to be mixed in an appropriate ratio of 60 to 74.5 wt% of purified deep water, salvia, rhyme, Baekchul, righteous, medicine, Hyunsam, Gyeenggeumumum, golden, licorice, raw jihwang, Dongguk, red peony, white sesame, bakgap, Bupyeong, dermis, sesao, ogapi, red ginseng, allies, vigor, poisonous life, white paper, sessin, Banggi, yellow lotus Countess, windproof, mold opening, creation, bark, silver, rhubarb, char, red spirit, taxi, wood, gypsum, horseback riding, jimo, bamboo leaf, cedar, taekran, gold silver, pogongyoung, tobokyeong, branch, windproof, etc. At least five or more herbs selected from 25 to 39.5% by weight and organic germanium 0.5 to 15% by weight consisting of 600m deep sea water and 1400m deep water was purified and mixed in a proper ratio, and then separately in Dansam, Unyeong, Exodus, Righteous, Poisonous, Hyunsam, Gyeenggeumumum, Golden, Licorice, Fresh green, Angelica, Red peony, White sesame, Thick, Bupyeong, Dermis, Sewao, Ogapi, Ginseng, Allies, Roots, Poisonous, White paper, Sessin, Banggi, Huangren, Countess, windproof, mold opening, creation, bark, silver, rhubarb, char, red spirit, taxi, wood, gypsum, horseback riding, jimo, bamboo leaf, cedar, taekran, gold silver, pogongyoung, tobokyeong, branch, windproof, etc. After extracting at least five or more selected herbal medicines from, purified deep water, herbal extracts and organic germanium is mixed to obtain a dietary supplement of the present invention, by taking it as well as gaining the efficacy as a dietary supplement as well as atopic dermatitis easily Could heal.
본 발명을 좀 더 상세히 설명하면 다음과 같다.The present invention is described in more detail as follows.
본 발명에 따른 아토피성 피부염에 효과적인 건강보조식품은 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 정제된 심층수 60 ∼74.5중량%, 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재 추출물 25 ∼ 39.5중량% 및 유기 게르마늄 0.5 ∼ 15중량%로 구성되는 것으로 특징지워진다.Health supplement foods effective for atopic dermatitis according to the present invention is purified 60 ~ 74.5% by weight of purified deep water of 600m deep sea water and 1400m deep water, mixed in an appropriate ratio, sweet ginseng, Unryeong, Baekchul, Uiin, mountain medicine, Hyunsam, Salary, golden, licorice, saengjihwang, Angelica, red peony, white sesame, thick pepper, Bupyeong, dermis, sesuo, ogapi, red ginseng, allies, vigor, poisonous, white paper, sesin, Bangui, rhubarb, earl, windproof, mold, creation, At least five kinds of Chinese herbal medicine extracts selected from the group consisting of peel, silver, rhubarb, tea, red spirit, taxa, wood, gypsum, horse riding, hairy, bamboo leaf, cedar, taekran, gold and silver, pogongyeong, bokbokyeong, branch, windproof, etc. It is characterized by consisting of 25 to 39.5% by weight and 0.5 to 15% by weight of organic germanium.
또한, 본 발명에 따른 아토피성 피부염에 효과적인 건강보조식품의 제조 방법은 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 다음에 별도로 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재로부터 추출물을 얻은 후에 이를 정제하고, 정제된 심층수, 한약재 추출물 및 유기 게르마늄을 균질하게 혼합하는 것으로 특징지워진다.In addition, the manufacturing method of the health supplement food effective for atopic dermatitis according to the present invention is purified by mixing the depth of seabed 600m deep water and 1400m deep water in an appropriate ratio and then separately, Salvia ginseng, Unyeong, Baekchul, Uiin, Sanin, Hyunsam, Hyun Gye, Gold, golden, licorice, green liquor, donkey, red peony, ringworm, thick, bupyeong, dermis, sesuo, ogapi, red ginseng, allies, vigor, poisonous, white paper, sesin, banggi, rhubarb, earl, windproof, mold, creation Extract from at least 5 kinds of Chinese medicines selected from the group consisting of silver, rhubarb, tea, tea, talc, keg, gypsum, horse riding, hairy, bamboo leaf, cedar, talc, talan, gold and silver, pogongyoung, bokbokyeong, branch, windproof, etc. After obtaining the purified it, it is characterized by the homogeneous mixing of the purified deep water, the herbal extract and the organic germanium.
본 발명에서 사용된 해저 600m의 심층수와 1400m의 심층수의 성분은 다음의 표 1과 같다.The components of the deep sea water of 600m and the deep seawater of 1400m used in the present invention are shown in Table 1 below.
[표 1]TABLE 1
상기 표 1로부터 알 수 있는 바와 같이 심층수에는 다양한 무기물 및 미량원소가 다량으로 함유되어 있고, 본 발명에서는 해저 600m의 심층수와 1400m의 심층수를 1 : 3 ∼ 3 : 1의 비율로 혼합하여 사용하였다.As can be seen from Table 1, the deep water contains a large amount of various minerals and trace elements, and in the present invention, a deep water of 600 m and a deep water of 1400 m are mixed at a ratio of 1: 3 to 3: 1.
해저 600m의 심층수와 1400m의 심층수를 혼합하여 사용하는 것이 바람직하지만 해저 600m 이하의 심층수면 모두 사용이 가능하며, 심층수에 함유되어 있는 다양한 무기물 및 미량원소가 피부 표면의 활력을 증진시키는 피부 보호 기능을 하기 때문에 효과적일 뿐만 아니라 인체에 균형을 유지케 하여 아토피성 피부염의 원인을 치유케하는 작용을 하고, 심층수를 취하여 -4 ∼ 0℃의 온도를 유지하면서 1 ∼2일간 정치하여 침전물을 제거한 후에 여과하는 방법으로 정제한 것을 사용한다.It is preferable to use a depth of 600m deep water and 1400m deep water, but it is possible to use both deep water below 600m below sea level, and various minerals and trace elements contained in deep water can provide skin protection function to enhance the vitality of the skin surface. Not only is it effective, it also maintains balance in the human body to heal the cause of atopic dermatitis, and takes deep water to keep the temperature at -4 to 0 ° C for 1 to 2 days to remove the precipitate before filtration. It refine | purifies by the method of using.
심층수의 사용량은 60 ∼ 74.5중량%가 바람직하며, 사용량이 60중량% 미만일 경우에는 아토피성 피부염의 치료 효과가 만족스럽지 못하고, 74.5중량%를 초과할 경우에는 건강보조식품으로서의 효능이 저하되는 단점이 있다.The amount of deep water is preferably 60 to 74.5% by weight, and when the amount is less than 60% by weight, the therapeutic effect of atopic dermatitis is not satisfactory, and when it exceeds 74.5% by weight, the efficacy as a dietary supplement deteriorates. have.
유기 게르마늄은 순도와 안전도가 매우 중요하며 체내에서의 소화 흡수 또한 매우 중요하기 때문에 분말 형상인 것을 심층수에 용해하여 사용하며, 분말의 상태가 순백색이고, 입자나 알갱이 같은 것이 없이 밀가루처럼 고우며, 분말의 상태가 덩어리처럼 뭉친 것이 없고, 불순물이 섞여 있지 않은 것을 사용하여야 하며, 60 ∼ 80℃의 물(증류수면 더 정확함) 50cc에 유기게르마늄 분말 20mg을 넣고 교반시 물에 완전히 용해되고, 용해후 오랜 시간이 지나도 침전물(불순물)이 생기지 않아야 하며, 물에 완전히 녹은 후에는 물이 크리스탈처럼 보통의 물보다 더 맑고 투명하게 되는 것을 선택하여 사용한다.Organic germanium is very important for purity and safety, and digestion and absorption in the body is also very important. So, it is used in the form of powder in deep water, and the powder is pure white, without powder or granules, like flour, powder It should be used without any clumps of lumps and without impurities. Add 20mg of organic germanium powder to 50cc of water (more accurate distillation surface) at 60∼80 ℃ and completely dissolve in water when stirring. Sediment (impurity) should not occur over time, and after it is completely dissolved in water, choose to make water clearer and clearer than ordinary water like crystal.
유기게르마늄이 함유하고 있는 산소는 세포안에서 발생기 산소로 방출되는 데, 보통 산소는 통상적인 상태에서는 분자 O2의 형태로 존재하지만 다른 물질과 화합할 때는 산소원자 0의 형태가 되며, 유기게르마늄은 발생기 산소를 빈사직전의 세포에 방출시켜 세포를 부활시키므로서 대사활동이라는 세포내 화학반응을 활성화시키게 되고, 세포는 본래의 기능을 되찾아 싱싱하게 작용하게 되며, 결과적으로 온몸의 컨디션이 호전되어 아토피성 피부염의 병원이 제거되는 것이다.The oxygen contained in organo germanium is released into the generator oxygen in the cell. Normally, oxygen exists in the form of molecule O 2 in a normal state, but when combined with other substances, it becomes in the form of oxygen atom 0, and organo germanium is a generator. By releasing oxygen to the cell just before death, the cell is revived, activating the intracellular chemical reaction called metabolic activity. Will be removed.
산의 바탕은 산소가 아니고 수소, 보다 정확하게 말하면 수소이온이고, 수소이온은 체내에서 쓸모가 전혀 없는 가스에 불과하지만 그것이 정도 이상으로 축적되면 체질이 산성화되었다고 하며, 컨디션을 무너뜨리는 계기가 되는 데, 이 불필요한 가스를 청소하는데 산소가 필요하며, 산소는 필요없는 수소이온과 결합하여 중성인 물이 되어 몸밖으로 배설되는데 유기게르마늄은 그것을 위한 산소를 공급하는 작용을 하며, 수은이나 카드뮴같은 유해한 중금속을 동반해서 체외로 배설시켜주는 역할을 한다.The base of the acid is not oxygen, but hydrogen, more precisely hydrogen ions, and hydrogen ions are nothing but useful gases in the body, but when they accumulate more than that, the constitution is said to be acidified. Oxygen is needed to clean up this unnecessary gas, and oxygen combines with hydrogen ions, which are not needed, to form neutral water and be excreted out of the body. Organic germanium acts to supply oxygen for it, accompanied by harmful heavy metals such as mercury and cadmium. It acts to excrete outside the body.
본 발명에서는 버섯, 고려인삼, 밤, 구기자 열매 등과 같이 게르마늄이 고단위로 함유되어 있는 식용 가능한 식물로부터 분리한 것으로, 마늘, 컴프리, 알로에, 표고버섯같은 버섯류도 유기 게르마늄원으로 사용될 수 있으며, "카르복시 에틸 게르마늄 32산화물"(분자식 : (GeCH2CH2COOH)2O3)이 특히 효과적이다.In the present invention, it is isolated from edible plants containing germanium in a high unit such as mushrooms, Korean ginseng, chestnuts, goji berries, etc., mushrooms such as garlic, comfrey, aloe, shiitake mushrooms can also be used as an organic germanium source, "carboxy Ethyl germanium 32 oxide "(molecular formula: (GeCH 2 CH 2 COOH) 2 O 3 ) is particularly effective.
유기 게르마늄의 사용량은 0.5 ∼ 15중량%가 바람직하며, 사용량이 0.5중량% 미만일 경우에는 유기 게르마늄의 효과 발현이 미약한 단점이 있고, 사용량이 15중량%를 초과할 경우에는 첨가 상승효과가 미약하여 경제적이지 못한 단점이 있다.The use amount of organic germanium is preferably 0.5 to 15% by weight, and when the amount is less than 0.5% by weight, there is a disadvantage in that the effect of organic germanium is weak, and when the amount is more than 15% by weight, the synergistic effect of addition is weak. There is a disadvantage that is not economic.
한편, 한약재는 피부 질환에 효능이 있는 것으로 알려져 있는 것들을 사용하되, 상호 효능이 상승 작용을 하는 것들을 사용하며, 한약재를 열수 추출하여 정치한 다음 여과한 것이 효과적이고, 한약재의 사용량은 25 ∼ 39.5중량%가 바람직하며, 사용량이 25중량% 미만일 경우에는 건강 보조 식품으로서의 효능 발현이 미약한 단점이 있고, 39.5중량%를 초과할 경우에는 심층수와 유기 게르마늄의 사용량이 상대적으로 감소되어 아토피성 피부염의 치료 효과가 미약한 단점이 있다.On the other hand, herbal medicines are used to be known to be effective for skin diseases, but the use of synergistic synergistic ones, the extraction of the herbal medicine by hydrothermal extraction and then filtered and effective, the use of herbal medicines 25 ~ 39.5 weight % Is preferred, when the amount is less than 25% by weight, there is a weak disadvantage in the expression of efficacy as a dietary supplement, and when the amount exceeds 39.5% by weight, the amount of deep water and organic germanium is relatively reduced to treat atopic dermatitis It has a weak effect.
다음의 실시예는 본 발명을 좀 더 상세히 설명하는 것이지만, 본 발명의 범주를 한정하는 것은 아니다.The following examples illustrate the invention in more detail, but do not limit the scope of the invention.
실시예 1Example 1
해저 600m의 심층수와 1400m의 심층수를 취하여 -4 ∼ 0℃의 온도를 유지하면서 1일간 정치하여 침전물을 제거한 후에 여과하는 방법으로 정제한 다음, 해저 600m의 심층수와 1400m의 심층수를 1 : 1의 비율로 혼합한다.Take 600m deep water and 1400m deep water and leave it for 1 day while maintaining the temperature of -4 ~ 0 ℃, remove the precipitate, and then purify by filtering. Then, 600m deep water and 1400m deep water is 1: 1 ratio. Mix with.
별도로 당삼 12g, 운령 9g, 백출 9g, 의인 15g, 산약 9g, 현삼 9g, 계내금 9g, 황금 6g, 감초 6g을 열수에 투입하여 6시간 동안 열수 추출한 다음, 실온으로 냉각하고 1일간 정치한 후, 침전물을 제거하여 한약재 추출물을 준비한다.Separately ginseng 12g, Haengyeong 9g, Baekchul 9g, Uinin 15g, medicinal 9g, Hyunsam 9g, sediment 9g, golden 6g, licorice 6g into hot water, extracted with hot water for 6 hours, cooled to room temperature and left to stand for 1 day, Prepare the herbal extract by removing the precipitate.
그 다음에 심층수 혼합물 68중량%, 한약재 추출물 30중량%와 식물성 카르복시 에틸 게르마늄 32산화물 2중량%를 혼합하고 교반하여 식물성 카르복시 에틸 게르마늄 32산화물이 완전히 용해되고, 각각의 성분들이 균질하게 혼합되도록 하여 본 발명의 건강보조식품을 제조하였다.Then, 68% by weight of the deep water mixture, 30% by weight of the medicinal herb extract and 2% by weight of the vegetable carboxy ethyl germanium 32 oxide are mixed and stirred to completely dissolve the vegetable carboxy ethyl germanium 32 oxide, and the components are mixed homogeneously. The health supplement of the invention was prepared.
실시예 2 ∼ 실시예 9Example 2-Example 9
사용된 한약재의 종류와 양이 표 2와 같이 변경된 것을 제외하고는 실시예 1과 동일하게 행하여 건강보조식품을 제조하였다.The health supplement was prepared in the same manner as in Example 1 except that the type and amount of the herbal medicines used were changed as shown in Table 2.
[표 2]TABLE 2
실험예 1Experimental Example 1
본 발명에 따른 건강보조식품의 인체에 대한 무독성을 입증하기 위하여 마우스를 대상으로 급성독성시험을 실시하였다.In order to prove the non-toxicity of the health food according to the present invention to the human body, an acute toxicity test was conducted in mice.
[급성독성시험][Acute Toxicity Test]
(1) 재료 및 방법(1) materials and methods
가) 실험동물A) Experimental animal
1) 종(계통) : ICR계 마우스(ICR mouse)1) Species: ICR mouse
2) 성별 및 입수시 주령 : 수컷 4주령2) Gender and age at acquisition: Male 4 weeks
3) 선택이유 : 본 실험에 사용된 ICR계 마우스는 전세계적으로 독성시험에 널리 사용되어 왔기 때문에 생리, 해부 및 독성학적 기초자료가 풍부하여 그 결과를 비교하기가 유리하고 또한 실험동물의 구입 및 사용이 편리하여 선택하였다.3) Reason for selection: Since the ICR mice used in this experiment have been widely used in toxicology tests all over the world, it is rich in basic physiological, anatomical and toxicological data, so it is advantageous to compare the results. Selected for ease of use.
4) 공급원 : 대륙시험동물4) Source: Continental Test Animal
5) 검역 및 순화기간 : 실험실에 순화시키는 기간을 약 1주일 두었으며, 그기간중 일반증상을 관찰하여 건강한 동물만을시험에 사용하였다.5) Quarantine and Purification Period: The period of purifying in the laboratory was approximately one week. During the period, general symptoms were observed and only healthy animals were used for the test.
6) 정맥주사시 체중범위 및 주령 : 20±3g, 5주령6) Weight range and age at intravenous injection: 20 ± 3g, 5 weeks
7) 사용동물수 : 100마리(예비시험 포함)7) Number of animals: 100 (including preliminary test)
8) 군 분리 및 동물시별 : 시험에 사용된 건강한 동물의 체중을 측정하여 각 군의 평균체중이 거의 일치하도록 군 분리를하였고, 개체식별은 피모색소(피크린산) 마킹법과 사육상자별 TAG 표시법을 이용하였다.8) Group Separation and Animal Time: The weights of healthy animals used for the test were divided into groups so that the average weight of each group was almost identical. The individual identification was performed by the method of marking pigmented pigment (picrinic acid) and TAG by breeding box. Was used.
나) 동물실B) animal room
1) 온, 습도범위 : 온도 22±2℃, 상대습도 53±2%1) Temperature and humidity range: temperature 22 ± 2 ℃, relative humidity 53 ± 2%
2) 명암 사이클 : 형광등조명(09:00 점등~18:00 소등)2) Contrast cycle: Fluorescent lighting (09:00 to 18:00 off)
3) 조도 : 150~300Lux3) Roughness: 150 ~ 300Lux
4) 사육상자의 종류 : 순화, 검역, 투여 및 관찰기간 중 마우스용 플리카보네이트(polycarbonate)케이지(대종기계제작)4) Types of breeding box: Polycarbonate cage for mouse during purifying, quarantine, administration and observation period (manufactured by Daejong Machinery)
5) 사육상자당 동물수 : 순화, 검역기간 -5마리5) Number of animals per breeding box: Purified, quarantine period-5
투여기간-5마리Dosing period-5
다) 사료C) feed
1) 종류 : 실험동물용 고형사료1) Type: Solid feed for laboratory animals
2) 공급원 : 삼양유지사료주식회사2) Source: Samyang Oil Feed Co., Ltd.
라) 음수D) negative
1) 종류 : 여과된 수도수1) Type: filtered tap water
마) 시험물질E) test substance
1) 시료 : 상기 실시예 1에서 제조된 조성물(1000배 희석액)1) Sample: The composition prepared in Example 1 (1000-fold dilution)
공시험액(음성대조군)Blank test amount (negative control)
바) 투여방법F) Method of administration
1) 투여경로 : 경구투여(Oral)1) Route of administration: Oral administration (Oral)
2) 투여회수 및 투여기간 : 1회투여2) Number of administration and period of administration: 1 administration
3) 투여부위 및 투여법 : 마우스에 경구투여하였다.3) Administration site and administration method: The mice were orally administered.
4) 투여시각 : 10:00~12:004) Administration time: 10: 00 ~ 12: 00
5) 투여량 : 투여직전에 체중을 기준으로 하여 50ml/kg를 투여하였다.5) Dosage: 50ml / kg was administered immediately based on body weight.
(2) 시험방법(2) Test method
가) 국립보건원 독성시험에 따라 실시하였다.A) It was conducted in accordance with the National Institutes of Health toxicity test.
나) 임상증상관찰 : 전 동물에 대하여 매일 실시하였다.B) Clinical symptoms observation: All animals were conducted daily.
투여 후 6시간은 매시간 관찰하여 그후 5일간 1일 1회 운동성, 외관 및 자율신경증상을 주의 깊게 관찰하였다.Six hours after the administration was observed every hour, and carefully observed the mobility, appearance and autonomic symptoms once daily for 5 days thereafter.
다) 체중측정 : 전 동물에 대하여 투여 개시일과 2주 후에 측정하였다.C) Body weight measurement: All animals were measured after the start of administration and 2 weeks later.
(3) 시험결과(3) Test result
[표 3]TABLE 3
급성독성시험결과Acute Toxicity Test Results
[표 4]TABLE 4
본 발명의 건강보조식품을 투여한 마우스 1군의 체중변화Body weight change of the mouse 1 group administered the dietary supplement of the present invention
[표 5]TABLE 5
본 발명의 건강보조식품을 투여한 마우스 2군의 체중변화Body weight change of mouse 2 group administered the dietary supplement of the present invention
[표 5]TABLE 5
음성대조군을 투여한 마우스 1군의 체중변화Body weight change of mouse 1 group which received negative control group
[표 6]TABLE 6
음성대조군을 투여한 마우스 2군의 체중변화Weight Changes in Group 2 Mice Treated with Negative Control
이상의 결과에서 알 수 있는 바와 같이, 본 발명 실시예의 건강보조식품과 음성대조군의 경구투여 후 2주간의 관찰 결과, 체중과 운동성이 정상적인 것으로 관찰되었다.As can be seen from the above results, two weeks after oral administration of the health supplement food and the negative control group of the present invention, body weight and motility were observed to be normal.
실험예 2Experimental Example 2
실시예 1에서 제조된 건강보조식품을 아토피성 피부염 환자(5세부터 15세)30명에게 1일 3회 식후에 20ml씩 복용시키면서 5일마다 피부염의 정도를 관찰한 결과, 약 1달 후에는 26명의 환자에게서 완치가 되었으며, 2달 후에는 모두 완치되었고, 6개월 후에도 재발되는 환자는 1명도 없었다.As a result of observing the degree of dermatitis every 5 days while taking 20ml each of the dietary supplement prepared in Example 1 after a meal three times a day to 30 patients with atopic dermatitis (5 to 15 years old), 26 patients were cured, 2 months later, and 6 months later.
상술한 바와 같이 본 발명에서는 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 정제된 심층수 60 ∼ 74.5중량%, 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재 추출물 25 ∼ 39.5중량% 및 유기 게르마늄 0.5 ∼ 15중량%로 구성되어지되 해저 600m의 심층수와 1400m의 심층수를 정제하여 적정한 비율로 혼합한 다음에 별도로 단삼, 운령, 백출, 의인, 산약, 현삼, 계내금, 황금, 감초, 생지황, 당귀, 적작약, 백선피, 후박, 부평, 진피, 하수오, 오가피, 고삼, 우방자, 강활, 독활, 백지, 세신, 방기, 황련, 백작약, 방풍, 형개, 창출, 단피, 은화, 대황, 차전자, 적령, 택사, 목통, 석고, 승마, 지모, 죽엽, 목향, 택란, 금은화, 포공영, 토복령, 지부자, 방풍 등으로 구성되는 군으로부터 선택된 적어도 5종 이상의 한약재를 추출한 후, 정제된 심층수, 한약재 추출 물 및 유기 게르마늄을 혼합하여 본 발명의 건강보조식품을 얻고, 이를 복용하므로서 건강보조식품으로서의 효능을 얻는 것은 물론 아토피성 피부염과 각종 피부질환을 용이하게 치료할 수 있었다.As described above, in the present invention, 60 to 74.5% by weight of purified deep water mixed with an appropriate ratio of purified deep sea water of 600m and deep sea water of 1400m, sweet ginseng, nunyeong, baekchul, righteous, mountain medicine, Hyunsam, sediment, golden, licorice , Raw fish, Angelica, red peony, peony, peony, bupyeong, dermis, sesao, ogapi, red ginseng, allies, roaring, poisonous, white paper, sesin, banggi, rhubarb, white peony, windproof, mold opening, creation, peel, silver, rhubarb, 25 to 39.5% by weight of at least 5 kinds of Chinese herbal medicine extracts selected from the group consisting of chason, yeongnyeong, taeksaek, keg, gypsum, horse riding, jimo, bamboo leaf, mokyang, talan, gold and silver, pogongyeong, bokbokyeong, branch father, windproof Organic germanium is composed of 0.5 to 15% by weight of purified water and 600m deep sea water and 1400m deep water, and then mixed in an appropriate ratio, and then separately, red ginseng, nunyeong, baekchul, righteous, mountain medicine, Hyunsam, sediment, golden, licorice, green liquor , Donkey, peony, ringworm Blood, pak, bupyeong, dermis, sesuo, ogapi, red ginseng, allies, vigor, poisonous, white paper, seshin, banggi, rhubarb, earl of pill, windproof, mold opening, creation, short skin, silver, rhubarb, tea, red spirit, taxa, wooden barrel After extracting at least five or more Chinese herbal medicines selected from the group consisting of gypsum, horse riding, hair loss, bamboo leaf, Mokyang, talan, gold and silver, pogongyoung, Tobokyeong, branch father, windproof, etc., purified deep water, herbal extract and organic germanium By obtaining a dietary supplement of the present invention by mixing, taking it as well as obtaining the efficacy as a dietary supplement was able to easily treat atopic dermatitis and various skin diseases.
Claims (11)
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KR100931350B1 (en) * | 2009-10-23 | 2009-12-11 | (주)아모레퍼시픽 | Skin compositions for exteral application, containing plant extracts |
WO2012036446A2 (en) * | 2010-09-14 | 2012-03-22 | Song Yong-Won | Composition for treating atopic dermatitis using natural materials |
WO2012043920A1 (en) * | 2010-09-28 | 2012-04-05 | 한국 한의학 연구원 | Composition for preventing or treating atopic dermatitis including galenical extract or lactobacillus fermentation thereof |
KR101141191B1 (en) * | 2010-01-25 | 2012-05-04 | 한국식품연구원 | Functional food composition and pharmaceutical composition for the prevention and alleviation of allergy symptoms |
KR20190101258A (en) * | 2018-02-22 | 2019-08-30 | 백용준 | Composition for improving skin disease and manufacturing method thereof |
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KR20190101258A (en) * | 2018-02-22 | 2019-08-30 | 백용준 | Composition for improving skin disease and manufacturing method thereof |
WO2019177424A1 (en) * | 2018-03-16 | 2019-09-19 | 주식회사 헬릭스미스 | Crude drug composition for preventing or treating respiratory diseases |
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