KR20030074525A - Composite aroma composition for hastenning dophamin neutrotransmitter in the body - Google Patents

Abstract

PURPOSE: A composite aroma composition essentially containing an aroma component of lemon, bergamot, grape fruit, lime and fruits is provided. The composition exhibits substantial increase in an in vivo dopamine neurotransmitter release as a result of a urine test and significantly increases the alpha wave and degree of comfort of a worker, thereby providing an efficient working environment. CONSTITUTION: A composite aroma composition essentially contains 68 to 76% by weight of lemon, 4 to 7% by weight of bergamot, 18 to 20% by weight of grape fruit, 1.5 to 2.0% by weight of lime and 0.5 to 1.0% by weight of fruits. The fruits are selected from the group consisting of basil, chamomile, cedarwood, clary sage, eucalyptus, lavendar, rosemary, mint, geranium, ylang ylang, cinnamon, jasmine, sandalwood, rose wood, patchouli, clove, marjoram and frankincense.

Description

Composite aroma composition for hastenning dophamin neutrotransmitter in the body}

The present invention relates to complex aroma compositions for promoting dopamine neurotransmitters in the body, to effective conditions for using them, and systems thereof.

The role of mental function in work and learning is very important. In order to make the most appropriate response or judgment in the process of changing environment, physical condition, and psychology, it is necessary to concentrate, and to select and judge and move to action in a moment. You need to continue. In all cases, however, work efficiency is reduced due to fatigue, continuous work, time lapse, fatigue, age, physical disability, emotional disturbance, tension, vibration, noise, lack of motivation, indulgence, compromise, and request. Degradation or a lack of judgment is inevitable.

Until now, it has been known to consume glucose to maintain concentration during work or learning. However, this is a temporary increase in blood sugar level, which is not sustained, and also increases caffeine and hydrochloric acid cocaine. Stimulants and beta-blockers such as atenolol are known, but these drugs have side effects and are prohibited by the International Olympic Committee Physician Committee. In addition, creatinin tablets are also used, but the effect is reported to be not significant.

Dopamine is a secondary neurotransmitter in the brain. Since its discovery in the 1950s, dopamine function in the brain has been intensively studied. To date, it is theorized that dopamine is essential in many aspects of brain function, including exercise, cognition, sensation, emotion and autonomic (eg, appetite suppression, body temperature, sleep) functions, and thus the regulation of dopamine functional function is It can be effective in treating a wide range of disorders affecting brain function, and virtually both neurological and mental disorders are treated with medications based on the interaction of dopamine systems with dopamine receptors in the brain.

The present invention provides a safe and efficient control of dopamine in the body to function as described above, mainly due to psychological effects and / or exercise during exercise or learning, and / or a decrease or lack of concentration, It is an object of the present invention to provide a complex aroma composition for improving mental concentration and a system using the same, which can effectively and safely improve the work efficiency and learning efficiency by suppressing the psychological effects in psychological dysfunction such as accumulation of mental fatigue. . In particular, the present invention relates to a complex aroma composition for promoting dopamine neurotransmitters in the body that can be demonstrated objectively increased by dopamine content in the body by biometric data or brain wave experiments.

Regarding the essential oil for aromatherapy used in the present invention, the following is a detailed description. Aromatherapy with essence cell oil originates from the discovery of plant leaves, roots and stems in ancient Egypt, China and India, which have beneficial effects on the management of the human mind and body. The Greeks developed cosmetics using olive oil and myrrh and spread it to other countries. By the 18th and 19th centuries, the Greeks had been using it for skin care, body care and other folk remedies. Essential oils are sometimes referred to as "gi" or "hormones" of plants, and are known to play an important role in relieving the imbalance of the human body and as a source of life energy accumulated in high levels in plants.

The aromatherapy essential oils are applied to the human body by odor, and the inhalation of incense stimulates the cortical hormones of the cerebrum to regulate the balance of the body, which also reduces the size of abnormally enlarged body fat cells. Inhaled fragrance stimulates brain cells, giving them a nervous and brain function and sedative effect. Among these essential oils, for example, Basil, Bergamot, Chamomile, Cedarwood, Clary Sage, Eucalyptus, Lavendar, Rosemary Rosemary, Mint, Geranium, Jennifer, Ylang Ylang, Titory, Cinnamon, Jasmin, SandalWood, Grapefruit (Grape Fruits, Rose Wood, Patree, Grove, Majoram, Frankin Cense).

As a result of appropriately formulated and formulated aroma oils, the present inventors have conducted clinical studies, which show that dopamine neurotransmission can effectively and safely improve tension, atrophy, lack or lack of concentration, mental fatigue accumulation, and work efficiency and learning efficiency. In promoting the substance, the dopamine content in the body could be demonstrated objectively increased by biometric data or EEG experiments.

The technical problem to be achieved by the present invention is a complex that facilitates the dopamine neurotransmitter in the body that can prove the actual increase in dopamine neurotransmitters in the body as a result of the urine test, and objectively significant difference as a result of the EEG test It is to provide an aroma composition.

1A is a Yoshida vector model diagram before a mentally intensive state of a subject in an unscented state, and FIG. 1B is a Yoshida vector model diagram of a mental concentration of a subject in an unscented state.

Figure 2a is a graph showing the average frequency of the alpha wave of the subject's left brain when using the fragrance and fragrance A in order to promote the effect of the complex aroma composition to promote dopamine neurotransmitters in the body according to the present invention, Figure 2b is a fragrance and fragrance Figure 2c is a graph showing the average frequency of the alpha wave of the subject's left brain when using B, Figure 2c is a graph showing the average frequency of the alpha wave of the subject's right brain when using fragrance and fragrance A, Figure 2d is a graph of the subject's right brain when using fragrance and fragrance B Graph of alpha wave average frequency.

Figure 3a is a gradient aroma gradient of the subject's left brain when using the fragrance and fragrance A in order to promote the dopamine neurotransmitters in the body according to the present invention, Figure 3b is the subject's left brain when using fragrance and fragrance B 3C is a fluctuating rhythm gradient of the subject's right brain when unscented and fragrance A is used, and FIG. 3D is a fluctuating rhythm gradient of the subject's right brain when unscented and fragrance B is used.

Figure 4a is to explain the effect of the complex aroma composition for promoting dopamine neurotransmitters in the body according to the present invention, when using fragrance A and fragrance A, the comfortableness by the gradient of the alpha wave rhythm of the subject, Figure 4b is fragrance and fragrance A graph showing the comfort level according to the alpha wave fluctuation rhythm gradient of the subject when using B. FIG.

Figure 5a is a Yoshida vector model diagram after 40 minutes of intensive practice of the subject when using the fragrance and fragrance A in order to explain the effect of the complex aroma composition for promoting dopamine neurotransmitters in the body according to the present invention, Figure 5b When using perfume B, the subject is Yoshida vector model after 40 minutes of intensive practice, FIG. 5C is an unscented and fragrant A, Yoshida vector model diagram after 45 minutes of intensive practice of subject, and FIG. 5D is when using fragrance and perfume B, Yoshida vector model diagram after 45 minutes of intensive practice of subjects, FIG. 5E is a Yoshida vector model diagram after 50 minutes of intensive practice of fragrance and fragrance A, and FIG. 5F is intensive practice of subjects when fragrance and fragrance B is used. Figure of Yoshida vector model after 50 minutes.

Figure 6 is a graph showing the optimal injection cycle time considering the respective acclimatization of flavors A and B in order to explain the effect of the complex aroma composition for promoting dopamine neurotransmitters in the body according to the present invention.

Figure 7a is a graph showing the reaction time of the use and non-use of two psycho-intensive complex aroma stimulation system to explain the effect of the complex aroma composition for promoting dopamine neurotransmitters in the body according to the present invention, 7b is a graph depicting the concentration of two mentally intensive complex aroma stimulation systems with and without use.

In order to achieve the above technical problem, the complex aroma composition for promoting dopamine neurotransmitters in the body according to an aspect of the present invention lemon, bergamot, grape fruit, lime (lime) And in the composite aroma composition comprising essentially fruits aroma component,

68% to 76% by weight of the lemon, 18% to 20% by weight of the grapefruit, 4% to 7% by weight of the burger pegs, 1.5% to 2.0% by weight of the lime and 0.5% to 1.0 of the fruit It is characterized by containing a% by weight.

In a composite aroma composition comprising essentially lemon, bergamot, grape fruits, lime, and fruit aroma components,

68% to 76% by weight of the lemon, 18% to 20% by weight of the grapefruit, 4% to 7% by weight of the burger pegs, 1.5% to 2.0% by weight of the lime and 0.5% to 1.0 of the fruit A composite aroma composition for promoting dopamine neurotransmitters in the body, characterized in that it contains% by weight.

In addition, the fruit is Basil (Basil), Chamomile (Camomile), Cedarwood (Cedarwood), Clary Sage (Cary Sage), Eucalyptus (Eucalyptus), Lavendar (Rosemary), Rosemary (Mint) , Geranium, Jennifer, Ylang Ylang, Titory, Cinamon, Jasmin, SandalWood, Rosewood, Pastry ( Patree, Grove (Grobe), Majoram (Majoram) and Frankin Sense (Frankin Cense) is characterized in that consisting of an aromatic component selected from the group consisting of or a combination thereof.

In addition, the complex aroma composition, limonene (limonene) 60% to 70%, aldehyde C10 (aldehyde C10) 2.5% to 5.5%, aldehyde C14 (aldehyde C14) 1.5% to 2.5%, aryl heptanoate (allyl heptanoate) 1.5 It is preferable to contain%-2.5%.

In addition, the composite aroma composition, -Pinene ( -pinene 0.1% to 0.3%, citral 2.0% to 3.0%, citronelial 2.5% to 3.5%, linalool 0.5% to 1.5%, hexyl cinnamic aldehyde (hexyl) It is preferable to further contain 4.0% to 6.0% of cinnamic aldehyde, 0.7% to 1.3% of terpinyl acetate, 1.7% to 2.3% of tonalide and 2.0% to 4.0% of verdox. .

The aromatic components include aromatic components that are obvious in the art and can be used for the same or similar purposes as the purpose of the present invention.

In the present invention, within the range of effectively maintaining the mental concentration enhancing effect, the aromatic components may be added or deleted as appropriate, the compounding ratio may be appropriately added or subtracted, and those that may be suitably used for the purpose of the present invention.

Improving mental concentration above means that it is possible to safely and effectively improve tension, atrophy, deterioration and lack of concentration, accumulation of mental fatigue, and work efficiency learning efficiency.

The complex aroma composition for improving mental concentration of the present invention may further include appropriate carriers, excipients, and diluents commonly used in the preparation of aromas, and are in the form of tablets, capsules, emulsions, aerosols, and the like, according to conventional methods, respectively. Can be formulated and used.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

However, the following Examples and Experimental Examples are only illustrative of the present invention, and the content of the present invention is not limited to the following Examples and Experimental Examples.

Reference Example 1. Experimental apparatus and apparatus

In order to analyze the aroma component of Examples 1 and 2, the component evaluation and the solvent content were analyzed using the wavelength reflected by FT-IR scanning infrared rays in a sample. The clinical experiment was conducted at the Technical Support Building of the Korea Research Institute of Standards and Science, and the experimental equipment included MP System for measuring physiological signals (MP-100, Biopac System, USA), PC for signal collection and monitoring, electrodes, sensors, and hygrometers. A central rhythm monitoring system (HSK System, manufactured by HSK, Japan) was used to measure EEG and heart rate.

Example 1 Composition Ratio of Complex Aroma Compositions

Bergamot, Lemon, Grapefruit, Lime, and Fruit Base were mixed in the following composition ratios and used as samples (Table 1a and Table). 1b). Here, burger pegs, lemons, grapefruits, limes, and fruites are well known ingredients in the aroma field. In this experiment, fruit is added to within 1% to adjust the weight to 100% for the convenience of the experiment Basil (Chamomile), Chamomile (Cedarwood), Clary Sage, Eucalyptus (Eucalyptus) , Lavendar, Rosemary, Mint, Geranium, Jennifer, Ylang Ylang, Titory, Sinamon, Jasmin, Sandal Aroma oils selected from Wood, Rosewood, Patree, Grove, Majoram and Frankin Cense, or combinations thereof.

Composition ratio table of complex aroma composition (fragrance A) Aromatherapy ingredients % Composition Burger Pond 5% lemon 72% Grapefruit 20% Lime 2% Fruits (others) One%

Composition ratio table of complex aroma composition (fragrance B) Aromatherapy ingredients % Composition Burger Pond 4% lemon 76% Grapefruit 18% Lime 1.5% Fruits (others) 0.5%

Example 2 Composition Ratio of Complex Aroma Compositions

Bergamot, Lemon, Grapefruit, Lime, and Fruit Base were mixed in the following composition ratios and used as samples (see Table 2). .

Composition ratio table of complex aroma composition (fragrance C) Aromatherapy ingredients % Composition Burger Pond 7% lemon 68% Grapefruit 22% Lime 2% Fruits (others) One%

Comparative Example 1. Composition ratio of composite aroma composition

Bergamot, Lemon, Grapefruit, Lime and Fruit Base were mixed in the following composition ratios and used as samples (see Table 3).

Composition ratio table of complex aroma composition (fragrance D) Aromatherapy ingredients % Composition Burger Pond 2% lemon 80% Grapefruit 16% Lime 1.5% Fruits (others) 0.5%

Experimental Example 1. Component analysis of the composite aroma composition and the component aroma

Perfume A of the composite aroma composition prepared in Example 1, and the components of the constituent aroma oil burger moth, lemon, grapefruit, lime, and fruit to analyze the components of the FT-IR device of Reference Example 1 An analysis was performed and the results are as follows (see Table 4, Table 5, Table 6, Table 7, Table 8, and Table 9).

Component Analysis Table of Complex Aroma Composition (Fragrance A) Ingredient Name % Composition Limonene 65.00 Aldehyde C10 4.00 Aldehyde C14 2.00 Aldehyde C8 1.00 Aryl cyclohexyl propionate 0.50 Aryl heptanoate 2.00 Ronon 2.00 -Pinene 0.50 Turpin 0.30 -Pinene 0.20 Cis-3-hexenyl salicylate 2.30 Citral 2.50 Citronellial 3.00 D.M.B.C. Butyrate 1.00 Terpinene 0.20 Geranyl acetate 0.50 Hexyl cinnamic aldehyde 5.00 Linalol 1.00 Linalyl acetate 0.80 Myrsen 0.10 p-cymen 0.10 Terfinyl acetate 1.00 Tonalid 2.00 Burdox 3.00 100.00

In addition, the fragrance B was analyzed using an FT-IR instrument, and the results were 68.2% of limonene, 3.7% of aldehyde C10, 1.7% of aldehyde C14, and aryl heptanoate. ) 1.8%, -Pinene ( -pinene 0.2%, citral 3.0%, citronelial 2.8%, linalool 1.1%, hexyl cinnamic aldehyde 5.6%, terpinyl acetate ) 1.1%, tonalide 2.0%, verdox 3.2%, and 5.6% unknowns.

In addition, the results of the analysis using the FT-IR instrument for the fragrance C is 62.2% limonene (limonene), 5.4% aldehyde C10 (aldehyde C14) 2.3%, aryl heptanoate (allyl) heptanoate) 2.2%, -Pinene ( -pinene 0.27%, citral 2.9%, citronelial 3.4%, linalool 1.38%, hexyl cinnamic aldehyde 5.8%, terpinyl acetate ) 1.2%, tonalide 2.2%, verdox 3.8%, and 6.7% unknowns.

In addition, the analysis of the fragrance D using the FT-IR instrument results in 85.5% limonene (limonene), aldehyde C10 (aldehyde C10) 2.1%, aldehyde C14 (aldehyde C14) 1.3%, aryl heptanoate (allyl) heptanoate) 2.0%, -Pinene ( -pinene 0.05%, citral 4.6%, citronelial 3.4%, linalool 0.25%, hexyl cinnamic aldehyde 5.8%, terpinyl acetate ) 0.3%, tonalide 2.2%, verdox 3.8%, and 6.7% unknowns.

Burger Nails Component Analysis Table Ingredient Name Composition ratio (%) Aldehyde C-8 0.10 -Pinene 0.90 Terpinene 5.50 -Pinene 0.30 -Terpinyl acetate 1.80 Kampan 0.10 Dihydro linalol 0.70 Terpinolene 1.00 Limonene 38.00 Linalol 18.50 Linalyl acetate 18.00 Myrsen 0.50 Savinen 0.20 Terfinyl acetate 11.00 Unknown substance 3.40 100.00

Lemon analysis table Ingredient Name Composition ratio (%) Aldehyde C-8 0.10 -Pinene 1.00 -Pinene 0.60 Citral 5.00 Citral diethyl acetal 3.20 Geranyl acetate 0.60 Limonene 88.00 Linalol 0.30 Unknown substance 1.20 100.00

Grapefruit's Ingredient Analysis Table Ingredient Name Composition ratio (%) -Pinene 1.80 Limonene 96.00 Nut Carton 0.50 Unknown substance 1.70 100.00

Analysis table of lime Ingredient Name Composition ratio (%) -Pencil alcohol 1.00 -Pinene 1.50 Terpinene 12.00 -Pinene 2.90 Citral 1.40 Eucapitol 5.00 Isosineol 3.30 Limonene 65.30 Limonene oxide 1.10 Myrsen 0.30 Farah Siemens-8-o1 2.3 Unknown substance 3.90 100.00

Fruit Analysis Table Ingredient Name Composition ratio (%) Allyl caproate 2.00 Allyl cyclohexylpropionate 2.00 Allyl Oenanthate 12.00 Cis-3-hexanol 0.20 Cis-3-hexanyl salicylate 14.00 Dihydro myrsenol 5.00 Dimethyl Benzyl Carvinyl Butyrate 2.00 Dimethyl-3-cyclohexanylcarboxyaldehyde 10.00 Ethyl acetoacetate 3.00 Ethyl-2-methyl butyrate 0.60 Undi-laclactone 3.20 Hexyl cinnamic aldehyde 10.00 Orthobutt Butylcyclohexyl Acetate 20.00 Prenyl acetate 6.00 Trans-2-hexanal 4.00 100.00

Experimental Example 2 Construction of a Database of Mental Concentration

In order to construct a database of mental state of the present invention, the following experimental method was performed.

The subjects were 100 healthy male middle school students with an average age of 14 ± 2.6 years. Subjects entered the laboratory at a temperature of 24 ± 1.0 ° C and a humidity of 50 ± 10%, and attached sensors of each measurement item, and measured brain waves after PC game and mental load after 10 minutes before mental concentration. .

As a result of depicting the mental concentration database as a Yoshida vector model, it was found that the psychotropic state in the unscented state showed pleasant and calm state (see FIG. Reference). In FIG. 1A and FIG. 1B, the lower right side shows discomfort and arousal tendency and means mental concentration.

Experimental Example 3. Verification of physiological and psychological effects of complex aroma for mental concentration

The actual physiological and psychological effects of the complex aroma enhancer of the present invention were verified by performing the following experiments.

Twenty male university students were selected as non-olfactory blindness subjects with an average age of 23.2 ± 0.6 years.They banned caffeine, smoking, and drinking from the day before the experiment, and got enough sleep. After checking, body temperature and blood pressure were measured, respectively. Subjects enter a laboratory with a temperature of 24 ± 1.0 ° C. and a humidity of 50 ± 10%, attach sensors to each measurement item, measure brain waves before mental concentration, and run a PC game for 60 minutes with mental concentration. The complex aroma stimulation (injection for 90 seconds after 40 minutes of PC game execution) and the anechoic stimulation conditions for each scent were prepared in the same time zone on different days, and the brain waves were measured. EEG was measured respectively.

As a result of comparing the average frequency of the alpha waves of the left and right frontal heads (Fp1, Fp2), the average frequency of the left and right brains of the two fragrance conditions and the unscented condition for each fragrance was distributed in the range of 9.40 to 10.19 ㎐, showing no significant difference between left and right. (See FIGS. 2A, 2B, 2C, and 2D).

In addition, as a result of comparing the rhythm gradient, the right brain (related to arousal and sedation) tended to be larger than the left brain (related to pleasure and discomfort). In particular, it was confirmed that the right brain inclination increased significantly according to perfume stimulation (** p <0.05, * p <0.1) (see FIGS. 3a, 3b, 3c and 3d).

As a result of comparing the comfort level by the slope of the alpha-wave fluctuating rhythm, it was confirmed that the fragrance increased after presentation of fragrance compared with the fragrance, especially after fragrance A stimulation (p <0.05) (see FIGS. . Significant increase was observed even after stimulation of perfume B and perfume C, but the significance was somewhat decreased (not shown). However, no significant difference was observed after perfume D stimulation of Comparative Example 1 (not shown).

As a result of comparing the Yoshida vector model based on alpha wave fluctuation rhythm gradient and comfort, it was confirmed that almost all subjects showed arousal effect (focus effect) for 15 minutes after perfume stimulation compared to unscented (FIG. 5A, 5B, 5C, 5D, 5E and 5F, where each symbol represents a subject and the hatched symbols represent unscented and the black filled symbols represent fragrance stimulation. Same model as shown.

Experimental Example 4. Determination of acclimation time and acclimatization removal time of complex aroma for mental concentration

In order to set the acclimation time and acclimatization removal time of the complex aroma for improving mental concentration of the present invention, the following experiment was performed.

Twenty male college students were selected as non-olfactory blindness subjects with an average age of 23.2 ± 2.6 years old.They banned caffeine, smoking, and drinking from the day before the experiment. After checking, body temperature and blood pressure were measured, respectively. Subjects enter the laboratory at a temperature of 24 ± 1.0 ° C and a humidity of 50 ± 10% and continuously spray each fragrance.The subject then measures the acclimated time, averages the time and determines the average acclimation time. In order to measure the acclimation time for each scent, first, A scent (or B scent) was injected to the scent by spraying the average acclimatization time ± standard deviation time, and then B scent (or A scent) in 30 second increments. ), The acclimation removal time was measured. The average acclimation time and acclimatization time experiments for each flavor were conducted at the same time zone on different days.

The results of measuring the compliance time and the elimination time of the fragrances A and B are shown in Tables 10 and 11 below, and it was confirmed that the optimum injection cycle time of the fragrances A and B could be determined (see FIG. 6). ).

Acclimation time of spices A and B Types of spices Acclimation time (sec) A 114 ± 78.86 B 166.6 ± 138.15

Acclimation removal time of fragrances A and B Types of spices Compliance removal time (seconds) A 120 B 40

Experimental Example 5. Development and effect of stimulation system of complex aroma for mental concentration

In order to develop a complex aroma stimulation system for mental concentration improvement of the present invention and to examine the effect was performed as follows.

Twenty male college students were selected as non-olfactory blindness subjects with an average age of 23.2 ± 2.6 years old.They banned caffeine, smoking, and drinking from the day before the experiment. After checking, body temperature and blood pressure were measured, respectively. Subjects were admitted to a laboratory with a temperature of 24 ± 1.0 ° C and a humidity of 50 ± 10%, using two mentally intensive complex aroma stimulation systems with and without conditions at the same time period on different days. Concentration and reaction time were measured.

Experimental results showed that the time spent playing PC games under the mentally intensive load when using the two psychotropic complex aroma stimulation systems was significantly reduced compared to when not using, especially after 45 and 60 minutes of use. It was confirmed that the (** p <0.05, * p <0.1) (see Fig. 7a). Significant increase was observed even after stimulation of perfume B and perfume C, but the significance was somewhat decreased (not shown). However, no significant difference was observed after perfume D stimulation of Comparative Example 1 (not shown).

In addition, the concentration of the PC game performed by the mental concentration load when using the two kinds of psycho-intensity complex aroma stimulation system was significantly increased compared with the non-use, especially after 30, 45 and 60 minutes of use. It was confirmed that the increase significantly (p <0.05) (see Fig. 7b).

Experimental Example 6. Changes in Dopamine for Aroma Stimulation

A urine test was performed to confirm the amount of change of dopamine, a neurotransmitter, to the complex aroma stimulation for mental concentration improvement of the present invention. As the equipment used for the urine test, the pump used Waters 602 manufactured by Millipore ™, and the detector used CULOCHEM2 manufactured by ESA ™, USA. Separation column was LICHSORB RP18 (diameter 5㎛) of the company.

As a result, there was no significant difference in the dopamine content of the subjects in the fragrance-free state, but the dopamine content was significantly increased after the perfume A stimulation in the aroma of the present application (see Table 12). In addition, it was confirmed that significantly increased after the stimulation of the perfume B and perfume C, but the significance was somewhat reduced (not shown). However, after perfume D stimulation of Comparative Example 1, there was no significant difference in the amount of dopamine in the subjects (not shown).

It should be noted that when using conventional aroma compositions, there was no aroma composition that demonstrated objectively increased dopamine levels in the body by biometric data or electroencephalogram experiments. On the other hand, the complex aroma composition according to the present invention showed that the dopamine neurotransmitter in the body actually increased as a result of the urine test, and as a result of the EEG test, there was an objective significant difference.

Dopamine Variation on Fragrance Stimulation Subject Dopamine Amount (ng / mg creatinine) Unscented Incense stimulation Before experiment 4 hours after the experiment Before experiment 4 hours after the experiment Sunwoo Kim 80.2 72.9 21.5 33.5 Yuhanjo 216.5 206.0 144.2 168.5 Jong Ho Lee 343.2 294.6 240.6 296.6 Sung Jin Hwang 241.8 200.5 214.7 237.9 Young Jin Hwang 180.9 165.0 180.8 223.3 Jang Jae Chul 230.9 270.2 201.7 205.6 Roh Young Kyun 270.7 273.1 276.5 351.0

The complex aroma composition provided by the present invention showed that the dopamine neurotransmitter substance in the body actually increased as a result of urine test, and it showed objectively significant difference as a result of EEG test.

Claims (4)

In a composite aroma composition comprising essentially lemon, bergamot, grape fruits, lime, and fruit aroma components, 68% to 76% by weight of the lemon, 18% to 20% by weight of the grapefruit, 4% to 7% by weight of the burger pegs, 1.5% to 2.0% by weight of the lime and 0.5% to 1.0 of the fruit A composite aroma composition for promoting dopamine neurotransmitters in the body, characterized in that it contains% by weight. The method of claim 1, wherein the fruit is Basil, Chamomile, Cedarwood, Clary Sage, Eucalyptus, Lavendar, Rosemary, Mint, Geranium, Jennifer, Ylang Ylang, Titory, Cinamon, Jasmin, Sandalwood, Rose Wood, Rose Tree, Patree, Grove ( Aromatic ingredients selected from the group consisting of Grobe, Majoram and Frankin Cense, or a combination thereof, the complex aroma composition for promoting dopamine neurotransmitters in the body. According to claim 1, The complex aroma composition, Contains 60% to 70% limonene, 2.5% to 5.5% aldehyde C10, 1.5% to 2.5% aldehyde C14, 1.5% to 2.5% aryl heptanoate Complex aroma composition that promotes dopamine neurotransmitters in the body. According to claim 3, The complex aroma composition, -Pinene ( -pinene 0.1% to 0.3%, citral 2.0% to 3.0%, citronelial 2.5% to 3.5%, linalool 0.5% to 1.5%, hexyl cinnamic aldehyde (hexyl) Dopamine neurons in the body further contain 4.0% to 6.0% cinnamic aldehyde, 0.7% to 1.3% terpinyl acetate, 1.7% to 2.3% tonalide and 2.0% to 4.0% verdox Complex aroma composition for promoting delivery material.