KR20030058870A - An adhere sheet for promote circulation of blood and manufacturing process therefor - Google Patents

Abstract

PURPOSE: Provided is a method of preparing an adhesive sheet for promoting blood circulation by mixing pyroligneous liquid with a component, which has good skin permeation effect and blood circulation promoting effect, aging and then coating on an adhesive sheet. Therefore, the adhesive sheet has an improved pharmacological action in blood flow. CONSTITUTION: Pyroligneous liquid is subjected to layer separation for 2 to 6 months, activated carbon treatment and fraction distillation in sequence. Thereafter, 60 to 70% by weight of purified pyroligneous liquid is blended with 10 to 20% by weight of starch and 20 to 30% by weight of crystalline cellulose and followed by hot air dried. And 10 to 25% by weight of purified pyroligneous liquid is blended with 70 to 85.5% by weight of starch, 0.5 to 1% by of Acanthopanacis cortex, 0.5 to 1% by weight of Kalopanax pictus(Thunb.) Nakai, 0.5 to 1% by weight of centipede powder, 0.5 to 1% by weight of aloe, 0.5 to 1% by weight of chito oligosaccharide, 0.5 to 1% by weight of Poria cocos, 0.5 to 1% by weight of Agaricus blazei Murill, 0.5 to 1% by weight of kelp powder, 0.5 to 1% by weight of green tea powder and followed by aging. The above mixtures are ground, mixed with rosin and then coated on a sheet.

Description

Manufacturing method and adhesive sheet for promoting blood circulation using wood vinegar {An adhere sheet for promote circulation of blood and manufacturing process therefor}

The present invention relates to an adhesive sheet for promoting blood circulation using wood vinegar, and more specifically, after mixing and ripening three steps of purified wood vinegar with the active ingredient, and drying the mixed ingredients, the active ingredient in a predetermined ratio The present invention relates to an adhesive sheet sealed by mixing again with a ceramic surface treated adhesive sheet.

Wood vinegar (木 酢 液) is an acidic liquid having a pH of about 3 produced by pyrolysis of wood, and is industrially obtained by collecting and liquefying smoke generated during carbonization of wood. Therefore, the active ingredients of the tree is excessively concentrated, and has recently been spotlighted as a useful material in various industrial fields.

In particular, wood vinegar is widely used as a therapeutic aid in the medical field, but it contains a large amount of harmful substances such as tar, methanol, and cresol along with its unique active ingredients. do.

When the wood vinegar is applied to the skin is known to act to quickly remove the harmful substances present in the subcutaneous and promote metabolism to recover the lesion site early. However, it is necessary to solidify the wood vinegar to some extent in order to apply it in the form of an adhesive sheet to the lesion area of the skin epidermis. In Japanese Patent Application No. 1999-377391, wood vinegar is mixed with crystalline cellulose, starch and PCS at 50 ° C. The technique of drying and preparing fine powder is described, and in Japanese Patent Application No. 99-207184 and Japanese Utility Model Registration Application 99-5455, a blood circulation promoting pressure-sensitive adhesive sheet prepared by mixing dried wood vinegar and starch spray-adsorbed an active ingredient It is mentioned.

However, the above technique cannot completely remove a large amount of harmful ingredients contained in the wood vinegar, which is a basic raw material, and also, by simply mixing the active ingredients, the activity of the active ingredients and sufficient subcutaneous absorption cannot be guaranteed.

The present invention is to overcome the above-mentioned conventional problems, an object of the present invention is to remove the harmful components of the wood vinegar, and added active ingredients with high subcutaneous penetration effect and blood circulation promoting effect, such as elvan, acaricus mushroom, genie powder Then, in order to maximize the activity of the active ingredients through the aging process and to evenly mix the trace active substances, the coating process is performed using a fluidized bed dryer to improve the blood circulation by applying a ceramic coating to the skin adhesive side of both sides of the adhesive sheet. It is to provide an adhesive sheet and a method for producing an adhesive sheet using the wood vinegar solution enhanced the effect.

Hereinafter, a method of manufacturing the adhesive sheet using the wood vinegar solution is as follows.

A step of inducing the separation into three layers in a container for a certain period of time by collecting the smoke coming from burning wood and natural cooling;

Separating the middle layer solution of the wood vinegar separated into three layers and putting it in another container for relayer separation and separating the middle layer solution;

3 steps of adding activated carbon to the purified wood vinegar through re-layer separation and stirring to remove harmful substances;

4 steps of preparing the wood vinegar by heating the wood vinegar purified by activated carbon at low temperature to collect the harmful components by fractional distillation, and remove the harmful components by fractional distillation at high temperature again;

5 steps of mixing starch and ogapi, thawed blood, centipede powder and plant powder to the wood vinegar and stirring at low speed for 5 to 10 days;

Adding starch and crystalline cellulose to the aged wood vinegar, mixing and drying at a predetermined temperature to prepare wood vinegar powder;

7 steps of spray drying or freeze-vacuum drying the wood vinegar powder after aging;

Eight steps of mixing the mixture with 20 to 60% of the wood vinegar solution and mixed with 40 to 80% of the mixed solution of starch, ganban powder, and plant powder, followed by low temperature drying of the fluidized bed;

The skin contact surface is a ceramic surface treatment and the opposite surface is a silver foil-treated SMMS adhesive sheet to put the final mixture of the above to complete the adhesive sheet; nine steps.

In the step 1, the layer separation container uses a length ratio of 1: 3 to 1: 8. If the ratio is less than 1: 3, the contact area between the layers is wider than the total volume of wood vinegar, and the recovery rate of wood vinegar is lowered. The layer separation period is from February to June. If it is 2 months or less, the layer separation is insufficient, and if it is 6 months or more, the degree of separation reaches a maximum and there is no need to separate it.

Activated carbon adsorption in step 3 is a process for removing harmful substances of high boiling point such as benzopyrene, phenol, cresol, etc., activated carbon has a diameter of 0.5cm to 2.0cm and the total volume of activated carbon is 20 ~ 30%. If the activated carbon is smaller than 0.5cm, the adsorption capacity is lowered. If the activated carbon is more than 2.0cm, the activated carbon suspended matter is crushed during stirring. In addition, if the total volume of activated carbon is less than 20% of the total volume including the wood vinegar solution, the adsorption capacity is insufficient, and if more than 30%, the adsorption capacity is excessive, thereby adsorbing the active ingredient. In stirring, the rotation speed of the stirrer is maintained at 20 to 60 times per minute, but when it is smaller than 20 times, the adsorption efficiency is lowered, and when 60 or more times, the activated carbon is crushed.

Low temperature purification in step 4 is carried out between 60 ~ 70 ℃ and high temperature purification is carried out between 100 ~ 110 ℃. Low-temperature refining is a process to remove low-boiling harmful substances such as methanol (boiling point 64.1 ℃), and high-temperature refining is to remove harmful substances with boiling points near the boiling point of water avoiding the boiling point of 117.8 ℃ of acetic acid, the main component of wood vinegar solution. .

In step 6, 10 to 20% starch and 20 to 30% crystalline cellulose are mixed and mixed with 60 to 70 wt% wood vinegar. Drying is carried out by the method of hot air drying method, and passing the dryer stream of 40-50 degreeC upward through a mixture.

The plant powder in step 5 is composed of aloe essence, chitooligosaccharide, Baekbongryeong, Akaricus mushroom, kelp powder, green tea powder. The content of each component is that wood vinegar is 10-25 wt%, starch 70-85.5 wt%, ogapi 0.5-1 wt%, thaw 0.5-1 wt%, genie powder 0.5-1 wt%, aloe Essence 0.5 ~ 1 wt%, chitooligosaccharide 0.5 ~ 1 wt%, Baekbongryeong 0.5 ~ 1 wt%, Akaricus mushroom 0.5 ~ 1 wt%, kelp powder 0.5 ~ 1 wt%, green tea powder 0.5 ~ 1 wt% do. When stirring, the rotational speed of the stirrer is maintained at 30 to 80 times per minute, and aged by stirring until the final viscosity is 0.2 to 0.3 Pa · s.

In the drying in the step 7, the spray drying is sprayed through the nozzle to the aged aged wood vinegar mixture atomized to a particle size of 0.5mm or less, and then dried in a rotating wind tunnel. After cooling to -40 ℃ and reduced the pressure to 0.02 ~ 0.14 psi to sublimate the moisture to dry.

In the drying of step 8, a mixture of starch, ganban powder, and plant powder mixed with the wood vinegar mixture is placed in a container, and hot air flows through the bottom of the perforated plate to cause fluidization to dry, discharge into an air blower, and uniform particle size. The plant powder uses aloe essence, chitooligosaccharide, Baekbongryeong, Akaricus mushroom, kelp powder, propolis, red ginseng, green tea powder. Elvanite uses powder ground to 60 ~ 300 mesh, but if it is pulverized below 60mesh, the powder is too fine and can pass through the pores of the surface of the adhesive sheet. You can reduce the fit. The mixture is 15 to 25 wt% of wood vinegar powder, 60 to 76 wt% of starch, 6 to 7 wt% of ganban stone powder, 0.5 to 1.0 wt% of aloe essence, 0.5 to 1.0 wt% of chitooligosaccharide, 0.5 to 1.0 wt of Baekbyeongyeong. %, Akaricus mushroom 0.5-1.0 wt%, kelp powder 0.5-1.0 wt%, green tea powder 0.5-1.0 wt% is mixed.

In step 9, the adhesive sheet uses a non-woven fabric of SMMS type, which is spunbond, melt brown, melt brown, and spunbonded nonwoven fabrics. In addition, the adhesive sheet completed by spraying the mixed liquid mixed with the ceramic body pulverized to about 150 ~ 300mesh to the rosin of the liquid adhesive on the inner surface of the skin-side adhesive sheet. The other side is aluminum silver foil coating, which completely blocks the outflow of the active ingredient.

Hereinafter, specific embodiments will be described in detail.

(Example)

Example 1 Purification of Wood Vinegar

The smoke carbonized from the oak at 1300 ℃ was collected in a separate tank through a collecting pipe located above and continuously liquefied using a cooling pipe installed inside the tank. The wood vinegar collected in the tank was sealed in a glass bottle having a diameter of 20 cm and a height of 130 cm, and left for 3 months to separate layers. Then, the intermediate layer was collected, and the intermediate layer was collected by separating the intermediate layer for 2 months. During the above process, the tank for collecting wood liquor was made of resin to prevent corrosion due to acidity (about pH 3) of wood vinegar.

20 kg of the layered wood vinegar was placed in a stirrer, activated carbon having a diameter of about 1 cm was added 25% to the total volume, and stirred at a rate of 40 times per minute. After purification, the wood vinegar was passed through a nonwoven fabric to remove activated carbon.

The wood vinegar adsorbed and purified with activated carbon was heated at 60 ° C. for 30 minutes to remove low boiling point harmful substances, and again heated at 100 ° C. for 15 minutes to remove middle boiling point harmful substances.

Example 2 Preparation of Wood Vinegar Powder

In Example 1, 20 kg of purified wood vinegar, 3 kg of starch, and 7 kg of crystalline cellulose were mixed and stirred while passing a hot air at 45 ° C. upwards.

8 kg of starch, 80 g of ogapi, 80 g of thawed bark, 80 g of Jinhae powder, 80 g of green tea powder were mixed with the processed wood vinegar solution and stirred at a speed of 60 times per minute in a stirrer for 7 days. The aging temperature at this time was 30 degreeC.

20 kg of the aged wood vinegar mixture was placed in a cooling tank at minus 35 ° C. and vacuum-dried under reduced pressure to 0.05 psi. 20 kg of the processed wood vinegar was added to a fluidized bed drier, and 50 g of trace urea propolis, 80 g of red ginseng, and 80 g of chitooligosaccharide were mixed and coated with a hot air at 40 ° C. 1 kg of the dried fluidized bed dry powder and 1 kg of the lyophilized powder were mixed.

2kg of the dried wood vinegar powder, 7.2kg starch, 200mesh ganban stone powder 600g, aloe essence 40g, chitooligosaccharide 80g, Baekbongryeong 85g, Acaricus mushroom 95g, kelp powder 90g, green tea powder 100g by mixing the wood vinegar and active ingredients The powder was completed.

Example 3 Preparation of Adhesive Sheet

Prepare spunbond and melt brown, each 5 cm and 10 cm wide, and spun bond, melt brown, melt brown, and spun bond into four layers to make a nonwoven fabric, and prepare two nonwoven fabrics and rosin one surface of one nonwoven fabric And a mixture of 250 mesh ceramic sieve was sprayed and adhered, and the ceramic body was spray-dried on the inside, and the adhesive was applied to the outer three sides of the two nonwoven fabrics and the two nonwoven fabrics were attached thereto. 3.5 g of the mixture was added and the other side was sealed by bonding. And the outer surface was silver foil coating process.

As described above, the adhesive sheet using the wood vinegar according to the present invention completely removes harmful substances in the wood vinegar, and undergoes a separate aging process to maximize the activity of the active ingredient, particles highly uniform distribution by fluidized bed drying Is produced, and a large amount of blood circulation improving substances, such as centipede and scabies, is added, and the adhesive sheet is strengthened by pharmacological effect by surface-treating the ceramic body on the 4-layer adhesive sheet coated with silver foil.

Claims (2)

The wood vinegar was layered twice in a container having an aspect ratio of 1: 3 to 1: 8 for 2 to 6 months; 0.5 to 2.0 cm diameter activated carbon was added to the layered wood vinegar, and 20 to 30% of the total volume was added thereto, followed by stirring and purification. Adsorption-purified wood vinegar was purified by fractional distillation at 60 to 70 ° C and 100 to 110 ° C, respectively; 10 to 20 wt% of starch, 20 to 30 wt% of crystalline cellulose and 60 to 70 wt% of the wood vinegar, followed by hot air drying at 40 to 50 ° C; The wood vinegar is 10 ~ 25 wt%, vinegar 10 ~ 25 wt%, starch 70 ~ 85.5 wt%, ogapi 0.5 ~ 1 wt%, thaw 0.5 ~ 1 wt%, centipede 0.5 ~ 1 wt%, aloe essence 0.5 ~ 1 wt%, chitooligosaccharide 0.5 ~ 1 wt%, Baekbongryeong 0.5 ~ 1 wt%, Acaricus mushroom 0.5 ~ 1 wt%, kelp powder 0.5 ~ 1 wt%, green tea powder 0.5 ~ 1 wt%, and stirred at a speed of 30 ~ 80 times per minute for 7 days. Ripening; Freeze-vacuum drying of the aged wood vinegar mixture by spray drying or decompression to 0.02 to 0.14 psi under a temperature of -20 ° C to -40 ° C; 20 to 60% of the wood vinegar mixture, 15 to 25 wt% of wood vinegar, 60 to 76 wt% of starch, 6 to 7 wt% of ganban rock powder, 0.5 to 1.0 wt% of aloe essence, 0.5 to 1.0 wt% of chitooligosaccharide, Baekbongryeong 0.5 ~ 1.0 wt%, acaricus mushroom 0.5 ~ 1.0 wt%, kelp powder 0.5 ~ 1.0 wt%, green tea powder 0.5 ~ 1.0 wt% mixed with 40 ~ 80% of mixed solution and stirred Preparing a powder; The prepared powder is spray-bonded by mixing the ceramic body of 150 ~ 300mesh in rosin on one side, and the opposite side is on the adhesive sheet made of silver foil coated spun bond, melt brown, melt brown, and spun bond quad layer nonwoven fabric. Manufacturing method of the adhesive sheet for promoting blood circulation, characterized in that the sealing. Adhesive sheet for promoting blood circulation produced by the manufacturing method of claim 1.