KR20020062474A - Composition of herbs having curing effects for vaginitis and lecorrhea, and hygienic pad manufactured using the Composition - Google Patents

Abstract

PURPOSE: A herb medicine having a vaginitis treatment effect and a sanitary pad manufactured by using the herb medicine are provided to achieve a functional sanitary pad having outstanding ventilation ability, antibiosis, and various disease treatment effect related with the vagina. CONSTITUTION: The herb medicine for the sanitary pad having vaginitis treatment effect consists of 9-22 wt.% of Cortex Hibisci Syriaci; respectively, 6-7 wt.% of Radix Sophorae, Rhizoma Atractylodis, Cortex Phellodendris, Fructus Torilis, Olium Camphorae, Radix Stemonae, Alumen, Pericarpium Zanthoxyli, Cortex Dictamni, Sanguis Draconis, Herba Menthae, Flos lonicerae, and Cortex Ailanthi. The method for manufacturing the sanitary pad is comprises of steps of; preparing the herb medicine composition; pulverizing the herb medicine and heating obtained herb medicine powder of 150-250g in a distilled water of 1500-2500ml having a temperature of 80-120deg.C; concentrating filtered solution; lyophilizing the concentrated solution at -60 to -80deg.C to pulverize it, and sterilizing obtained powder with distilled water; and spraying and drying the manufactured herb medicine power onto a pad.

Description

Composition of herbs having curing effects for vaginitis and lecorrhea, and hygienic pad manufactured using the Composition}

The present invention relates to a herbal medicine composition for producing a sanitary napkin pad having a woman's vaginitis and cold soothing efficacy, a sanitary napkin pad manufacturing method and a sanitary napkin pad.

Women's vaginitis is one of the gynecological diseases with hypothermia, which is a common disease among women, and it is very difficult to treat because it does not develop badly and is often eradicated even if treated.

Patients with vaginitis have severe pain in the vulva and urinary tract with sputum, and redness and hyperemia of the vaginal mucosa, especially in the epithelium, urinary tract and perineum of the vaginal opening.

The vaginitis occurs when you have sex, wear tight pants, sit on the floor at excessively high temperatures, slow cell development in the vaginal wall, pregnancy, foreign body enters the vagina, chronic inflammation of the cervix, and stool in the vagina. When buried, it is caused by the overdosage of antibiotics and the destruction of normal vaginal bacteria.

Among the causes of vaginitis, infectious factors are the biggest problem, especially caused by protozoa Trichomonas, fungi such as Candida albicans, Haemophilus, herpes virus, anaerobic bacteria, Gardnerella vaginalis and mycoplasma hominis.

Infectious vaginosis can lead to serious consequences such as premature birth, low body weight, amniitis, endometriitis after cesarean section, pelvic inflammatory disease after abortion, and cellulitis after hysterectomy. It may cause inconvenience.

In addition, before puberty or postmenopausal, the vaginal epithelium is thin and easily infected by various pathogens such as gonococcus and nonspecific bacteria. Candida infection can occur throughout the vaginal epithelium if there is a systemic disease such as diabetes.

Treatment of vaginitis is carried out according to each cause of vaginitis. In women of childbearing age, effective treatment can be performed by detailed planar examination and appropriate culture test. Other causes of vaginitis also require ongoing treatment to prevent recurrence and may require continued follow-up.

As a general treatment for vaginitis, metronidazole and clindamycin are used for anaerobic bacterial infections such as Trichomonas vaginitis and Gardnerella vaginalis, and azol or fluconazol is used for Candida vaginitis, and estrogen cream is used for atrophic vaginitis.

However, the use of such general yeast infection treatment or antibiotics is easy to cause the replacement of normal lactic acid bacterium in the vagina that maintains the proper acidity of secretion in the vagina with pathogenic anaerobic bacteria. Is difficult, has many side effects, and often recurs.

The Trichomonas protozoa of vaginitis caused by the Trichomonas protozoa is a parasite that is transmitted through sexual intercourse as a sexually transmitted disease, and has a strong propagation force. Both treatments should be treated, especially with a lot of cold running water like panties that are wet, odorous, tingling or itchy. The treatment is metronidazole, which is highly effective and contagious.

Vaginitis caused by a fungus such as Candida albicansra is the most common form of vaginitis, which can be characterized by white thick cold and severe itching, with the expression of cold like mashed or curd or cheese. Itching often goes unknowingly, and it is very common for prolonged use of antibiotics or for pregnant or diabetic patients.

The use of common vaginitis medications or antibiotics exacerbates this vaginitis, and the treatment is a difficult to cure and recurrent vaginitis with azol or fluconazol.

Atrophic vaginitis in postmenopausal women causes a large amount of cold and sexual intercourse with thinning of the vaginal wall due to the lack of estrogen, a female hormone, and dryness due to vaginal epithelial cell atrophy, and a small amount of bleeding after sex. The treatment is treated with estrogen cream.

Bacterial vaginosis refers to vaginitis caused by alteration of harmless lactobacillus in the vagina that is normally called nonspecific vaginitis or Gardnerella vaginitis, or by replacement with anaerobic bacteria.

But what is causing this change is unknown, but there are reports that frequent vaginal lavage is involved. The main symptom is a fishy, fishy swelling, along with cold and malaise.

These odors are more prominent after sexual intercourse. These odors are due to a substance called "amine," and if you have bacterial vaginitis, you are more likely to have pelvic inflammatory disease. If you have bacterial vaginitis during pregnancy, the amniotic membrane that surrounds your baby will become inflamed and amniotic fluid. It can burst early and cause premature birth, which can cause problems for your baby.

Treatment is with metronidazole or clindamycin. However, long-term use may have other side effects and risks.

As described above, the conventional disease and its treatment method are mainly antibiotic-based treatments, which may cause hypersensitivity reactions in some patients, and there is a risk of worsening symptoms by eliminating all existing beneficial strains in the vagina.

Also, because of cold, using a pad that is not well ventilated and non-microbial, there is a risk of blocking the gout and worsen the symptoms.

The cause of cold medicine and cold treat is mainly related to wet death. The wet sand damages the vein (대), vein (帶 脈), esophagus (二 脈) causes a febrile symptoms. There are two paths that cause hyphae to cause subfebrileness, and one of them is the texture of the hygiene from the outside (menstrual period, after the childbirth is invaded by wetlands, moist heat (주 注) or unhygienic problems due to moist heat and poisoning ( (I) caused by direct damage to the veins and veins due to invasion, or when the moist has occurred in the body (the moist generated in the body is (unlicensed) due to impaired function or license) Due to insufficiency in lung function or lack of Xinyang due to lack of good culture, it is impossible to warm bite, or it is intermittent by intermittent gas. (Iii) is caused by the range). Symptom-based treatment is as follows.

The oriental medical causes and treatments for trichomoniasis vaginitis are divided into moist subfebrile fever and renal hysteresis. 열의 色, foam (泡沫), external ulcers (外陰 瘙痒), heartburn, (heart 煩 易 怒), sul bakni, sputum saek (므로) so symptomatic because it shows Soyangsim, Gosam, Baekbu-geun, casualty, and large-scale construction Applicable to rhubarb (大便 乾 結 加大 黃) and the new habits are a great ocean, white or yellowish white (白色 或 黃 白色), ulum yangyang (外陰 瘙痒), Yocheoksancho (설), Sultaebakni, Maxiyeon (脈 細軟) to show symptoms, such as Boshinyo (補腎 利 腰), blue heat moisturizing (淸 熱 利 濕) therapy to use the Shingihwan combination compared to Samhyeongtang.

Other therapies include Hakseol, Ginseng, Ginseng, Weisheng, Dongguk, Casualties, and readings to fumulate and clean the vulva. It is made from powdery white powder and used as a quality medicine.

The oriental medical causes and treatments for candidiasis vaginitis include non-pervasive symptoms such as lobster white, kidnapping, vulva vulgaris and seoltaebakbaek. ), And the treatment of dry skin control and pesticide use in the treatment of Maxe-yu's symptoms. It shows large white, white, erosion, Yocheoksancho, cotton, pale, pip, seoldam, bakbaek, and maxi yeon. Therefore, in the Shinshin Humidity (신), high speed vein Onsinja Matang (소 馬 湯) Soyangsim casualty (백 加 蛇床子), Baiseonpi (白 蘚 皮), Low back pain, Tosa (腰痛 加 兎 絲 子), Golden Primrose (金 櫻子) is used.

Other therapies include creation, gold and silver, baekbugeun, yellow baek, huang, flowers, alum, hojanggeun, ginseng, Casualties (蛇床子), branch (地膚 子), baekseonpi (白 蘚 皮) by attaching fumonic vulva and wash. Also, red ginseng, Tobok-ryeong, Baekbu-geun, Baeksunpi, White-bu-ja, Jigunja, Togwanpi, flowers and Yongdamcho草) and alum (明礬) to absorb the drug in cotton wool to use as a vaginal suppository.

Chinese medicine cause and remission of senile atrophy of senile atrophic vaginitis include lobster, vaginal dry shovel, vaginal dry shovel, uric acid ulcer, snow red Jibaekjihwangtang was used as a method of strengthening consonants and dying of high-velocity bands. Shiho (上 熱潮 紅 加 柴胡), golden (黄 芩), yellow white (黃柏), Seonbibi (仙靈 脾) and heart turmeric, Fuxin (心悸 心慌 加 神), Omija (五味子), Wheat (小 맥), Baekdaeda is a golden primrose (白帶 多加 金 櫻子), keel (龍骨), shao (牡蠣) is used.

Hyperthermia is known as large yellowish yellow, malodor, old dry mouth, urinary tract deformity, tongue sulphate, and maximal sac 역) such as Yeokhwangtang, Jibaekjihwangtang (易 黃 湯 合 知 柏 地 黃 湯) that shows the effect of moisturizing 청 (,), consonant bosin (효능) effect.

Other therapies include red ginseng, Baibu-geun, casualty, Jibu-ja, Baisun-pi, white-root, purple gentian (龍 膽 草), yellowish white (黄柏), flowers (花椒), creation (蒼朮), and decoction to clean the vulva and washes, yellow lotus (yellow), yellow white (黄柏), earrings (歸 尾) , Turmeric (薑黃), raw land (生地) and decoction to use as an ointment.

External vulgaris is used for external dental treatment. In other words, by applying the temperature and humidity effect of the drug to promote local blood, lymphatic circulation and expand the blood vessels of the affected area to apply the drug to promote the osmotic and absorption of the drug. Symptoms such as ulceral dysmenorrhea, urinary dysentery, baekhwasachopogongyeong Pogongyoung hwahwagyeong designated 黄花 地 丁 Hwangbaek ducts (green heat detoxification) ) (連 翹) (淸 熱 解毒), Jilin, Gil noise, etc. with 1000-2000ml of the liquid amount is washed 1-2 times daily or 30 minutes each day or bathe.

The vaginal taxation method is used to inject vaginal strength into the vagina to make the vagina clean and at the same time use the drug acting directly into the vagina. Sahwa-tang (Yang-Yu-Yang) in Saeng-tang (Yang-Yang) ), And anticoagulant detoxifiers (came ginseng, Tobok-ryong, Hwangbaek Jin-yeon, Ohjeolgol Yongdamcho), etc., are used once a day, about 500ml.

In addition, the drug is put into the vaginal drug (질) into the vaginal drug concentration is relatively high and the action time is long. It also acts directly on the vaginal or cervical exophores to exert a therapeutic effect. Hwang-yeon Hwang-baek, Hwang-baek, who has the effect of clearing detoxification, and the effect of detox-rejection. The white pearl and the convergence hemostasis are used for the efficacy of astringent and astringent dysentery. Powder the medicine or put it into the vagina as a whole, capsule, ointment.

The above-mentioned oriental medicine treatment shows a certain effect and relatively few side effects, but it is difficult to use extensively in medical treatment due to the unification of the dosage form and the inconvenience of measuring and using a certain dose.

An object of the present invention is to improve the problems of the conventional yeast infection treatment as described above and to produce a convenient functional sanitary napkin with the efficacy of treating diseases as a product that can be conveniently used in general life, The nonwoven fabric is made of antimicrobial nonwoven fabric which can reduce the chance of bacterial infection, and it is made of the product which improves breathability, and selects the herbal medicine used for the treatment of cold sores caused by vaginitis to form a new prescription medicine and process it on the pad. Its purpose is to produce a functional sanitary napkin by applying it to a sanitary napkin.

In order to achieve the above object, a description will be given of the herbal composition and the sanitary pad pad manufacturing method and sanitary pad pad having a technical composition of the sanitary napkin pad having the efficacy of treating the yeast infection and cold treatment of the present invention as follows.

Herbal medicine composition for the manufacture of sanitary pads of the present invention is 9-22% by weight of the neck roots, red ginseng, creation, yellowish white, casualty, camphor, albino, alum, cheoncho, ringworm, red blood, peppermint, gold silver, low root white blood It is characterized by containing 6-7% each.

Sanitary napkin pad manufacturing method of the present invention in order to manufacture a sanitary napkin pad having the efficacy of treating yeast infection and cold hypothalamus 9-22% of the neck bark, ginseng, creation, yellowish white, casualty, camphor, baekbugeun, alum, cheoncho , Ringworm, blood red, peppermint, gold and silver, and myopia containing 6-7% to form a herbal medicine;

Pulverizing the composition of the herbal medicines and powdering them, adding 150-250 g of the powder to 1500-2500 ml of distilled water, and then bathing them in an 80-120 ° C. water bath;

Filtering the heated bath liquid and centrifuging it, refiltering it, and concentrating the filtrate;

Freezing and drying the concentrated concentrate at -60 to -80 ° C to powder and dissolving the powder in distilled water to sterilize;

It characterized in that it comprises a step of spraying the sterilized herbal medicine to a pad for producing a sanitary napkin and drying.

In addition, the sanitary napkin pad of the present invention is characterized in that it is produced by the sanitary pad pad manufacturing method.

The herbal medicine of the present invention having such characteristics is used as an external medicine and develops useful medicines for treating such hypothermia and vaginitis in clinical practice, and applies it to sanitary pads to increase the convenience of use and to reduce side effects of treating vaginitis and cold Herbal Medicine for the Prevention and Treatment of Hypothyroidism and Infectious Yeast Infection in Women To make functional sanitary napkins, there are few side effects among the herbal medicines, which can be used for external use. A prescription that is effective for the treatment of infectious vaginitis and its resulting cold hypothalamus as a complex prescription was added.

We formulated these prescriptions to be used for sanitary pads and attached them to highly breathable pads and non-woven fabrics to make functional sanitary napkins that can be used for prevention and treatment of cold sores caused by vaginitis in women. .

The present invention has been formulated with the herbal medicine of Table 1 below for the treatment of hypothermia and prevention of infectious vaginitis due to vaginitis and shows the effect of treating inflammation and the prescription that can be used for the treatment of cold hypothalamus ( Iii)

The medicinal herbs used in this experiment were collected and used based on the origin of Chinese medicinal herbs, and the necessary parts were selected and used as the following method. The amount and content and experimental efficacy of the herbal medicines are shown in Table 1 below.

Creation of the Marshland Highland About people One medicine Scientific name Capacity (wt /%) Used part Neck Root Cortex Hibisci Syriaci Hibiscus syriacus L. 9-22 Transdermal Gosam (苦 蔘) RadixSophorae Sophora flavescens Ait. 6-7 A bare root Creation RhizomaAtractylodis Atractylodesjaponica Koidz. 6-7 near distance Yellow Baek CortexPhellodendris Phellodendronamurense Rupr. 6-7 Bestiality Casualties FructusTorilis Torilis japonica DC. 6-7 fruit Camphor OliumCamphorae Cinnamomum camphora Sieb. 6-7 Volatile Oils in Distilled Crystals Baekbugeun RadixStemonae Stemona japonica Miq. 6-7 Scrotum Alum Alumen Alunite 6-7 Processing Crystal of Alum Minerals Cheoncho PericarpiumZanthoxyli Zanthoxylum bungeanum Maxim. 6-7 Mature rind Ringworm CortexDictamni Dictamnusdasycarpus Turcz. 6-7 Muscle Red blood Sanguisdraconis Daemonorops draco Bl. 6-7 Fruit resin Peppermint HerbaMenthae Mentha arvensis var.piperascens Malinv. 6-7 Ground Outpost Gold and silver coins FlosLonicerae Lonicera japonica Thunb. 6-7 Lightning Low root white skin CortexAilanthi Ailanthusaltissima Swingle 6-7 Endothelial muscles

Samhwadaejigogo (渗濕 止 帶 膏) having the composition as described above is dried Chinese herbal medicine collected according to the herbal medicine experiment method to accurately select and cut small necessary medicinal parts, crushed by an automatic grinder and then to the pulverized powder 150-250g 1500-2500 mL of distilled water was added thereto, followed by bathing in an 80-120 ° C. water bath for 2-4 hours.

The filtered solution was filtered through a filter paper, centrifuged at 3,000 rpm, re-filtered, and the filtrate was concentrated using a rotary vacuum evaporator, and then freeze-dried at -60--80 ° C to use as a sample. It was. The powdered sample was dissolved in distilled water, adjusted to the required concentration, and used by filtration sterilization.

Measurement of the medium and bacterial culture conditions and growth inhibition ring and minimum growth inhibitory concentration (MIC) is a liquid culture of each bacterial strain for 18-24 hours in Mueller Hinton Broth and Sabouroud Dextrose Broth under appropriate culture conditions.

Luria-Bertani medium was used for the culture of E. coli and Bacillus subtilis used as control strains, Brucella Media was used for the Gardnerellar vaginalis culture, and tryptic soy agar was used for the Candida albicans.

The pH of the medium to be used is prepared by adjusting in the range of 6.8-7.4 and sterilized for 20 minutes at 121 ℃. Each bacterial strain cultured in liquid was plated on agar (agar 1.5%) medium of each bacteria prepared using a sterile disposable inoculation loop. The prepared 6.25 mm disks were sufficiently wetted with the prepared wetlands and the strains were properly placed on the agar plate smeared.

After plate plating, the agar medium plate on which the disk was placed was incubated for 24 hours at an appropriate temperature and condition for culturing each strain, and then the diameter of the growth-lowering ring was measured. A test medium was prepared by adding a sample to the medium for each concentration of the wetlands.

After culturing each strain in a wetland medium medium adjusted for each concentration for 24 hours, the minimum sample concentration of growth inhibition of each bacterium was determined by using a spectrophotometer. The absorbance of the medium containing the sample material was measured and the blank value was calculated and compared with the control.

Strains Used and Culture Conditions Species Strain No. Culture Condition Medium Temp. Aeration Escherichia coli 0157 ATCC 35150 Mueller HintonBroth & Agar, LB 35 ℃ Anaerobic Klebsiella pneumoniae ATCC 13883 Mueller HintonBroth & Agar 35 ℃ Anaerobic Enterobacter cloacae ATCC 23355 Mueller HintonBroth & Agar 35 ℃ Anaerobic Escherichia coli ATCC 25922 Mueller HintonBroth & Agar 35 ℃ Anaerobic Staphylococcus aureus ATCC 29213 Mueller HintonBroth & Agar 35 ℃ Anaerobic Staphylococcus epidermidis ATCC 12228 Mueller HintonBroth & Agar 35 ℃ Anaerobic Streptococcus pyogenes ATCC 19615 Mueller HintonBroth & Agar 35 ℃ Anaerobic Proteus vulgaris ATCC 13315 Mueller HintonBroth & Agar 35 ℃ Anaerobic Serratia marcescens ATCC 8100 Mueller HintonBroth & Agar 35 ℃ Anaerobic Salmonella typhimurium ATCC 14028 Mueller HintonBroth & Agar 35 ℃ Anaerobic Enterococcus faecalis ATCC 29212 Mueller HintonBroth & Agar 35 ℃ Anaerobic Pseudomonas aeruginosa ATCC 27853 Mueller HintonBroth & Agar 35 ℃ Anaerobic Streptococcus pneumoniae ATCC 6305 Mueller HintonBroth & Agar 35 ℃ Anaerobic Yersinia enterocolitica ATCC 9610 Mueller HintonBroth & Agar 35 ℃ Anaerobic Bacillus subtilis ATCC 6051 Mueller HintonBroth & Agar, LB 30 ℃ Anaerobic Listeria monocytogenes ATCC 19114 Mueller HintonBroth & Agar 37 ℃ Anaerobic Candida albicans ATCC 10231 Sabouraud DectroseBroth & Agar 30 ℃ Anaerobic Grananella vaginalis ATCC 14018 BM 30 ℃ Anaerobic

The antimicrobial effect of the 18 pathogenic strains shown in Table 2 was treated by extracting Swallow-West extract. As a result, as shown in Table 3 below, the antibacterial action of the wetlands was shown to inhibit the growth of various strains including G. vaginalis, which is a representative strain for causing vaginitis.

Proliferative inhibitors against Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, Listeria monocytogenes, Grananella vaginalis, and Candida albicans showed an excellent antimicrobial effect of 15 mm or more. In particular, it showed excellent anti-proliferative effect on grananella vaginalis and fungi Candida albicans , which causes vaginitis, and showed resistance to causative agents of vaginitis.

Therefore, if these drugs are properly applied to sanitary napkins, it is thought that they will prevent and treat vaginitis. The minimum growth inhibitory concentration of the wetland altitude is shown to be the minimum growth inhibitory concentration at the concentration of 0.625-1.25 ㎎ / ㎖.

Size and Minimum Growth Retardation Concentrations of Growth Inhibitory Rings in the Wetlands Species Strain No. Diameter of Clear Zone (mm) MIC of SJG (mg / ml) Escherichia coli 0157 ATCC 35150 13.4 ± 1.2 1.25 Klebsiella pneumoniae ATCC 13883 7.8 ± 1.0 5.0 Enterobacter cloacae ATCC 23355 13.1 ± 1.3 1.25 Escherichia coli ATCC 25922 14.4 ± 1.4 0.625 Staphylococcus aureus ATCC 29213 16.9 ± 1.2 0.625 Staphylococcus epidermidis ATCC 12228 14.1 ± 1.0 1.25 Streptococcus pyogenes ATCC 19615 9.7 ± 1.0 5.0 Proteus vulgaris ATCC 13315 8.1 ± 1.3 5.0 Serratia marcescens ATCC 8100 7.8 ± 1.2 5.0 Salmonella typhimurium ATCC 14028 13.1 ± 1.3 0.625 Enterococcus faecalis ATCC 29212 14.6 ± 1.0 0.625 Pseudomonas aeruginosa ATCC 27853 13.8 ± 1.3 0.625 Streptococcus pneumoniae ATCC 6305 15.6 ± 1.5 0.625 Yersinia enterocolitica ATCC 9610 10.1 ± 1.2 1.25 Bacillus subtilis ATCC 6051 15.4 ± 1.4 0.625 Listeria monocytogenes ATCC 19114 17.7 ± 1.6 1.25 Candida albicans ATCC 10231 13.6 ± 1.3 0.625 Grananella vaginalis ATCC 14018 18.8 ± 1.0 0.625

The anti-inflammatory action of the swamp wetland proved experimentally by the following method. The experimental animals were fed Sprague-Dawley female rats weighing about 200 g and Balb / C male mice weighing about 20 g and then mixed with general diets (Samyang feed: more than 22.1% of crude protein, 3.5% of crude fat, 5.0% of crude fiber, and 8.0% of crude powder) , Calcium 0.6% 以上 and phosphorus 0.4% 以上) for more than 1 week to adapt to the laboratory environment was used for the experiment.

The environment of the animal breeding room was maintained at a temperature of 22.1 ° C. and a relative humidity of 65.5%, and the contrast was adjusted at intervals of 12 hours (08:20:00). During the experiment, water and the basic formula were freely eaten. Sampling zone extract extracted by the above method was diluted with distilled water and administered orally or subcutaneously.

In order to measure the effects on carrageenin-induced edema, 6 rats were treated as a group according to Winter et al. (10 mg / kg), indomethacin (Normal Group) administered with water, basic formula and saline solution. Control group, SJG I, 100 mg / kg body weight, SJG II, 200 mg / kg body weight, 400 mg / kg body weight It was divided into experimental group III (SJG III).

1 hour after oral administration of the sample, carrageenin (0.1 ml of a 1% solution / suspension in saline) was injected under the spinal cord of the Fuji-U, with inflammatory agents, and the swelling developed over 5 hours after 1 hour intervals. The plethysmometer was used to measure the volume of the foot.

Vr-Vc Edema Growth Rate (%) = ---------- x 100Vc

Vr: The volume of the Fuji group who developed edema after carrageenin (0.1 ml of a 1% solution / suspension in saline)

Vc: Volume of the normal Fujiu before administration of carrageenin (0.1 ml of a 1% solution / suspension in saline)

Protein exudation experiment by CMC-pouch was performed according to the method of Ishikawa with 6 rats as a group.

Inject anesthetized rats with ketamine (20mg / kg) and Rumpun (10mg / kg), remove the hairs of the belly with a diameter of 5cm or more and inject 5ml of air into the subcutaneous air to create an air sac. The following treatment was performed. The experimental group was divided into five groups as follows.

In other words, 50 mg of aspirin was dissolved in 5 ml of 2% CMC (carboxymethyl cellulose) solution in a control group injected with 2 ml CMC (carboxymethyl cellulose) 5 ml / air pouch, autoclaved at 120 ° C. for 30 minutes. Drug-Experimental Group injected into the sac, 1 mg of Swallow-Glass Extract, dissolved in 5 ml of a 2% CMC (carboxymethyl cellulose) solution, and injected into the air sac. Experimental group II (SJG II) dissolved in 5 ml of CMC (carboxymethyl cellulose) solution and injected into the air sac, and experimental group III (SJG III) injected into air sac by dissolving 10 mg in 5 ml of 2% CMC (carboxymethyl cellulose) solution. to be.

After 6 hours of treatment, the CMC bag was gently massaged, and the fluid in the bag was taken to measure protein. Protein quantification was performed by adding 4.9 ml of physiological saline to 0.1 ml of the sample, carefully mixing the white blood cells to prevent destruction of the white blood cells, and then centrifuging at 1000 rpm for 5 minutes to remove blood cells, and then taking the supernatant and taking an automated analyzer (Gilford Impact 400E). Colorimetric measurement was carried out using.

As shown in Table 4 and Table 5, the anti-inflammatory action of the extract of Swallow-Plant was confirmed by Carragenin-induced edema and protein exudation by CMC-pouch.

The control group treated with physiological saline showed edema growth rate of 35.7 ± 2.8% at 1 hour after induction of edema, and gradually increased with time to 51.3 ± 3.6% at 3 hours, and 48.6 ± 3.4 at 5 hours. It was reduced by%.

In the anti-inflammatory drug control group treated with indomethacin, the increase rate was significantly decreased compared to the control group at 1 hour after induction of edema, and the edema growth rate was slowed at 2 and 3 hours even in the experimental group treated with SWW.

At 3 hours of maximal edema growth rate, 29.8 ± 2.9% in the drug control group and SWG Ⅱ and Ⅲ showed significant edema inhibitory effect compared to the control group, showing an anti-inflammatory effect similar to indomethacin.

Six hours after the experimental treatment, the protein exuded due to the inflammatory response to the CMC-pouch was measured. In the control group treated with carboxylmethyl cellulose, the protein exudation amount was 15.5 ± 1.4 mg / ml. In the case of administration, the protein exudation amount was 10.6 ± 1.2 ㎎ / ml, which showed a significant decrease compared to the control group, and the wetland extract extract group also showed the effect of suppressing the concentration of protein exudates. It seems to have a suppressing effect.

Effect of Aqueous Extracts from Samwet-Taego High-Earth Extract on Inflammation-induced Edema Experimental Group Increasing Rate of Paw-Edema (%) 1 hour 2 hour 3 hour 5 hour CONT (6) 35.7 ± 2.8 43.3 ± 3.1 51.3 ± 3.6 48.6 ± 3.4 SJG I (6) 33.1 ± 2.4 35.1 ± 2.9 37.3 ± 3.4 * 38.2 ± 2.9 SJG II (6) 30.4 ± 1.9 33.5 ± 2.6 * 33.7 ± 2.8 ** 36.3 ± 2.7 * SJG III (6) 29.4 ± 2.8 32.5 ± 2.6 * 32.1 ± 2.5 ** 34.3 ± 2.3 ** IDM (6) 25.3 ± 2.6 * 29.1 ± 2.3 ** 29.8 ± 2.9 ** 30.5 ± 2.9 **

Effect of Aqueous Extracts from the Wetlands on Protein Leakage due to Inflammation Experimental Group Protein (mg / ml) Inhibiation Rate of Protein leakage (%) CONT (6) 15.5 ± 1.4 - SJG I (6) 14.4 ± 1.2 7.1 SJG II (6) 12.1 ± 1.6 15.5 SJG III (6) 11.2 ± 1.2 * 27.7 Aspirin (6) 10.6 ± 1.2 ** 31.6

Taken together, Samwhaji-daego extract is an antimicrobial anti-inflammatory drug in Chinese herbal medicine. It shows antimicrobial effect on several strains, especially Grananella vaginalis and Candida albicans. . In addition, because it exhibits an anti-inflammatory effect, there is an advantage in the prevention of symptoms of vaginitis in women caused by various bacteria.

The present invention as described above is to improve the problems of conventional yeast infection treatment and to manufacture a convenient functional sanitary napkin with the efficacy of treating diseases as a product that can be conveniently used in general life, non-woven fabric which is a raw material of sanitary napkin It is made of antimicrobial non-woven fabric that can reduce the chance of bacterial infection, and it is made of product which improves breathability, selects herbal medicines used for the treatment of cold sores due to vaginitis, formulates new prescription drugs and sanitizes them to be processed on pads. Applying it to a sanitary napkin has a unique effect on the treatment of vaginitis and cold sores in women.

Claims (3)

By weight%, it contains 9-22% of neck root skin, 6-7% of red ginseng, creation, yellowish white, casualty, camphor, white root, alum, cheoncho, ringworm, red blood, peppermint, gold and silver, and low root white skin. Herbal medicine composition for the production of sanitary pads having a woman's vaginitis and cold treat effect. In order to prepare sanitary pads with efficacy in treating vaginitis and cold sores in women, 9-22% of the neck roots, red ginseng, creation, yellow white, casualty, camphor, white muscle, alum, cheoncho, ringworm, red blood, mint, Comprising 6 to 7% each of the gold, silver and low myrtle skin to form a herbal medicine; Pulverizing the composition of the herbal medicines and powdering them, adding 150-250 g of the powder to 1500-2500 ml of distilled water, and then bathing them in an 80-120 ° C. water bath; Filtering the heated bath liquid and centrifuging it, refiltering it, and concentrating the filtrate; Freezing and drying the concentrated concentrate at -60 to -80 ° C to powder and dissolving the powder in distilled water to sterilize; Method for producing a sanitary napkin pad having the efficacy of treating yeast infection and cold sores characterized in that it comprises the step of spraying the sterilized herbal medicine to a pad for producing a sanitary napkin. Sanitary pads having efficacy of treating vaginitis and cold sores in women prepared by the method of claim 2.