KR20010092418A - 다중 도메인의 당단백질 호르몬과 그 이용 방법 - Google Patents
다중 도메인의 당단백질 호르몬과 그 이용 방법 Download PDFInfo
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/175,017 US6635256B1 (en) | 1998-10-19 | 1998-10-19 | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
| US09/175,017 | 1998-10-19 | ||
| PCT/US1999/023555 WO2000023473A1 (en) | 1998-10-19 | 1999-10-12 | Multiple domain glycoprotein hormones and methods of using |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010092418A true KR20010092418A (ko) | 2001-10-24 |
Family
ID=22638493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017004919A Ceased KR20010092418A (ko) | 1998-10-19 | 1999-10-12 | 다중 도메인의 당단백질 호르몬과 그 이용 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6635256B1 (https=) |
| EP (1) | EP1123315A1 (https=) |
| JP (1) | JP2002533300A (https=) |
| KR (1) | KR20010092418A (https=) |
| CN (1) | CN1330665A (https=) |
| AU (1) | AU774432B2 (https=) |
| BR (1) | BR9914670A (https=) |
| CA (1) | CA2347062A1 (https=) |
| CZ (1) | CZ20011388A3 (https=) |
| HU (1) | HUP0103760A3 (https=) |
| IL (1) | IL142681A0 (https=) |
| NO (1) | NO20011925L (https=) |
| PL (1) | PL347375A1 (https=) |
| TR (1) | TR200101463T2 (https=) |
| WO (1) | WO2000023473A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001333772A (ja) | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
| AU2001255624A1 (en) * | 2000-04-25 | 2001-11-07 | Washington University | Single-chain fertility hormones with variable lh activity |
| AU2001283319A1 (en) * | 2000-08-11 | 2002-02-25 | Applied Research Systems Ars Holding N.V. | Glycoproteins and methods of use thereof |
| US6987172B2 (en) * | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| US7081446B2 (en) * | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| DE602004030546D1 (de) | 2003-03-04 | 2011-01-27 | Aspenbio Pharma Inc | LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers. |
| JP4412989B2 (ja) * | 2003-12-15 | 2010-02-10 | 株式会社日立製作所 | 複数の記憶システムを有するデータ処理システム |
| US20080039372A1 (en) * | 2005-07-21 | 2008-02-14 | The Trustees Of Columbia University In The City Of New York | Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation |
| US9707276B2 (en) | 2012-12-03 | 2017-07-18 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CA3140267A1 (en) | 2019-05-16 | 2020-11-19 | Ceva Sante Animale | Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0578328B1 (en) | 1983-11-02 | 1999-12-29 | Applied Research Systems ARS Holding N.V. | Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit |
| CA1213537A (en) | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| US5338835A (en) * | 1989-02-21 | 1994-08-16 | Washington University | CTP-extended form of FSH |
| ES2098261T3 (es) | 1989-02-21 | 1997-05-01 | Univ Washington | Formas modificadas de hormonas reproductoras. |
| WO1991016922A1 (en) | 1990-05-08 | 1991-11-14 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| CA2097291A1 (en) * | 1990-12-13 | 1992-06-14 | David P. Gearing | Leukemia inhibitory factor receptors |
| WO1992022568A1 (en) * | 1991-06-18 | 1992-12-23 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| ZA942206B (en) * | 1993-04-01 | 1994-10-31 | Amgen Inc | Biologically active polypeptide fusion dimers |
| DK0751782T3 (da) | 1994-02-18 | 2007-01-29 | Applied Research Systems | Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet |
| PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
| US6103501A (en) * | 1997-11-17 | 2000-08-15 | Washington University | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
-
1998
- 1998-10-19 US US09/175,017 patent/US6635256B1/en not_active Expired - Lifetime
-
1999
- 1999-10-12 HU HU0103760A patent/HUP0103760A3/hu unknown
- 1999-10-12 PL PL99347375A patent/PL347375A1/xx not_active Application Discontinuation
- 1999-10-12 BR BR9914670-3A patent/BR9914670A/pt not_active Application Discontinuation
- 1999-10-12 IL IL14268199A patent/IL142681A0/xx unknown
- 1999-10-12 WO PCT/US1999/023555 patent/WO2000023473A1/en not_active Ceased
- 1999-10-12 TR TR2001/01463T patent/TR200101463T2/xx unknown
- 1999-10-12 EP EP99954814A patent/EP1123315A1/en not_active Ceased
- 1999-10-12 JP JP2000577198A patent/JP2002533300A/ja active Pending
- 1999-10-12 CZ CZ20011388A patent/CZ20011388A3/cs unknown
- 1999-10-12 KR KR1020017004919A patent/KR20010092418A/ko not_active Ceased
- 1999-10-12 CN CN99813541A patent/CN1330665A/zh active Pending
- 1999-10-12 CA CA002347062A patent/CA2347062A1/en not_active Abandoned
- 1999-10-12 AU AU11072/00A patent/AU774432B2/en not_active Ceased
-
2001
- 2001-04-19 NO NO20011925A patent/NO20011925L/no not_active Application Discontinuation
-
2003
- 2003-08-21 US US10/647,088 patent/US7442376B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20011925D0 (no) | 2001-04-19 |
| US6635256B1 (en) | 2003-10-21 |
| PL347375A1 (en) | 2002-04-08 |
| TR200101463T2 (tr) | 2001-10-22 |
| AU774432B2 (en) | 2004-06-24 |
| JP2002533300A (ja) | 2002-10-08 |
| HUP0103760A2 (hu) | 2002-01-28 |
| US20040220088A1 (en) | 2004-11-04 |
| NO20011925L (no) | 2001-06-18 |
| EP1123315A1 (en) | 2001-08-16 |
| WO2000023473A1 (en) | 2000-04-27 |
| HUP0103760A3 (en) | 2003-09-29 |
| US7442376B2 (en) | 2008-10-28 |
| CZ20011388A3 (cs) | 2001-10-17 |
| AU1107200A (en) | 2000-05-08 |
| BR9914670A (pt) | 2002-02-05 |
| IL142681A0 (en) | 2002-03-10 |
| CA2347062A1 (en) | 2000-04-27 |
| CN1330665A (zh) | 2002-01-09 |
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| US5958737A (en) | Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto | |
| AU703718B2 (en) | Single-chain forms of the glycoprotein hormone quartet | |
| US6635256B1 (en) | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20010419 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20041011 Comment text: Request for Examination of Application |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20060125 Patent event code: PE09021S01D |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20061025 Patent event code: PE09021S01D |
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| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20070216 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20061025 Comment text: Notification of reason for refusal Patent event code: PE06011S01I Patent event date: 20060125 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |