KR20010067023A - Curing agents for born porosity symptom, arthralgia and arthritis, and the manufacturing method thereof - Google Patents
Curing agents for born porosity symptom, arthralgia and arthritis, and the manufacturing method thereof Download PDFInfo
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Abstract
Description
본 발명은 골다공증, 관절통, 관절염 치료제 및 그 제조방법에 관한 것으로, 보다 상세하게는 화목, 복숭아, 길핵, 복분자, 뱀딸기, 방가지풀, 은조롱, 가시오가피, 오리나무, 갈화, 골쇄보, 양강 등의 한약재를 주재료로 하여 골다공증, 관절통과 관절염에 탁월한 치료 효과를 갖는 골다공증, 관절통, 관절염 치료제 및 그 제조방법에 관한 것이다.The present invention relates to a therapeutic agent for osteoporosis, arthralgia, arthritis, and a method for manufacturing the same, and more particularly, to a flower tree, a peach, a gill nucleus, a bokbunja, a snakeberry, a branched grass, a silver gourd, a thorn stem, an alder tree, a brown flower, a bone clam beam, a lamb It is related to osteoporosis, arthralgia, arthritis treatment agent and a method of manufacturing the same as a main ingredient of osteoporosis, arthralgia and arthritis having excellent therapeutic effect on osteoporosis, arthralgia and arthritis.
일반적으로 골다공증은 뇌골수액이 모자라면서 발생하며, 일반적으로 골다공증으로부터 관절통 나아가서는 관절염으로 진행되는 것으로 알려져 있다. 한편, 뇌골수액이 모자라면서 우울증과 불안증세가 나타나므로, 이러한 심리적 요인으로 인하여 관절의 통증은 더욱 심해지게 되고, 그 결과 관절염 유발이 촉진된다는 보고도 있다. 그리고, 의학계의 연구보고에 따르면, 골다공증, 관절통 및 관절염을 치료하기 위해서는 인 등의 각종 미네랄을 보충해주며 장기를 튼튼히 해주고 정신적으로 안정을 찾게 해주는 것이 가장 필요하다고 한다.In general, osteoporosis occurs due to lack of cerebral bone marrow fluid, and it is generally known that osteoporosis progresses from osteoporosis to joint pain and arthritis. On the other hand, because of lack of cerebral bone marrow fluid, depression and anxiety appear, it is reported that these psychological factors are causing more pain in the joints, resulting in the promotion of arthritis. And, according to medical research reports, to treat osteoporosis, arthralgia and arthritis, it is most necessary to supplement various minerals such as phosphorus to strengthen the organs and find mental stability.
그러나, 현재 시중에 판매되는 화학 요법제들과 관절통 부위에 붙이는 팻취타입의 제품들은 치료제로서보다는 진통제로서의 작용을 하는 것이 대부분이며, 화학요법제의 경우에는 장기복용에서 오는 부작용을 피하기 어렵다는 문제점이 있고, 팻취타입의 경우에는 붙이고 오래 동안 지내야 하는 불편함과 함께 장기 부착으로 인하여 피부질환이 유발될 우려가 있다는 문제점이 있다.However, currently available commercial chemotherapy products and patch-type products attached to joint pain areas act as analgesics rather than as therapeutic agents, and in the case of chemotherapy, it is difficult to avoid side effects from long-term use. In the case of the patch type, there is a problem that the skin disease may be caused due to the long-term attachment with the inconvenience of sticking and staying for a long time.
본 발명은 상기와 같은 종래의 문제점을 극복하기 위하여 연구 개발된 것으로, 화목, 복숭아, 길핵, 복분자, 뱀딸기, 방가지풀, 은조롱, 가시오가피, 오리나무, 갈화, 골쇄보, 양강등이 한약재를 주재료로 하여 인체에 대한 부작용 없이 골다공증, 관절통, 관절염을 치료하거나 개선시킬 수 있는 골다공증, 관절통, 관절염 치료제 및 그 제조방법을 제공하는데 그 목적이 있다.The present invention has been researched and developed in order to overcome the above-mentioned problems, such as hwamok, peach, gill core, bokbunja, snakeberry, branch grass, silver gourd, prickly pear, alder, brown flower, bone clasp, Yanggang, etc. It is an object of the present invention to provide an agent for treating osteoporosis, arthralgia, arthritis, and a method for manufacturing the same, which can treat or improve osteoporosis, arthralgia, arthritis without adverse effects on the human body.
본 발명은 화목, 복숭아, 길핵, 복분자, 뱀딸기, 방가지풀, 은조롱, 가시오가피, 오리나무, 갈화, 골쇄보, 양강 등의 한약재를 이용하여 골다공증, 관절통 및 관절염 치료제를 제조하는 것이다.The present invention is to prepare osteoporosis, arthralgia and arthritis therapies using herbal medicines such as firewood, peach, yeast nucleus, bokbunja, snakeberry, bergamot, silver gourd, prickly pear, alder, brownish, bone clam, Yanggang.
화목(학명: Alnus borealis Koidzumi)은 자작나무과 (Betulaceae)의 다년생 목본으로 자작나무의 경피로서 주성분은 베투로시드(betuloside=rhoddoddrin), 베투린(betulin), 매니톨(mannitol), 소르비탈(sorbital), 베투라제(betulase) 등이며 무독(無毒), 열독창(熱毒瘡), 거담, 소종해독작용, 편도선염, 급성유선염, 탕상, 소녀남드럼의 치료에 사용되는 약재이다.Flower tree (Alnus borealis Koidzumi) is a perennial tree of the birch (Betulaceae). ), Beturase, etc. It is a medicine used for the treatment of non-toxic, heat ulcer, expectorant, small detoxification effect, tonsillitis, acute mastitis, acupuncture, and girls' drums.
복숭아(학명: Prunus persica stokes)는 벚나무과(Drupaceae)의 다년생 목본으로 복숭아나무의 과육으로 주성분은 주석산 서당 등이며, 최음작용, 미독, 익면색, 간장익기, 폐병의 치료에 사용되는 약제이다.Prunus persica stokes is a perennial tree of the Druaceae family. Prunus persica stokes is a perennial tree of the Prunus tree.
길핵(학명: Citrus unshiu marcor)은 산초과(Rutaceae)의 다년생 상록소교본으로 규나무 및 동속식물의 씨앗으로 리모닌(limonin)이 주성분이며 무독(無毒), 요통(腰痛), 기통(汽筒), 소장산기, 주사비, 후비종창, 노력으로 인한 허약 요약, 진통, 거각의 치료에 사용되는 약재이다.Giltrus (citrus unshiu marcor) is a perennial evergreen textbook of the Rutaceae. Seeds of citrus and similar plants, limonin is the main ingredient, nontoxic, low back pain, and cylinder. It is a medicinal herb used in the treatment of small intestine, injection, post-swelling, weakness due to effort, analgesia and elevation.
산딸기(학명: Rubus coreanus Miq)는 장미과(Rosaceae)에 딸기 루부스 종(rubus sp.)의 다년생인 낙엽 관본으로 산딸기 및 동속식물의 미성숙한 과실이며 주성분으로는 주석산 당분 바이타민C 등이며 무독, 익기, 경신, 요통, 방광기통, 소장산기, 주사비, 장양, 자음 양기부진의 치료에 사용되는 약재이다.Raspberry (Scientific name: Rubus coreanus Miq) is a perennial deciduous tube of strawberry Rubus sp. In the Rosaceae, an immature fruit of raspberries and similar plants. It is a medicine used for the treatment of ripening, renewal, low back pain, bladder cylinder, small intestine, injection ratio, intestine, and constipation.
뱀딸기(학명: Duchesnea indica Focke)는 장미과(Rosaceae)에 두체스니아 종(duchesnea sp.)의 다년생인 초본(草本)으로 뱀 딸기의 미성숙한 과실과 경엽(莖葉)으로 무독(無毒), 해독(解毒), 지해(止咳), 암종(癌腫), 양혈(養血)암종에 사용되는 약재이다. 과실은 유독(有毒)하며 월경이상(月經異常)의 치료에 효과가 있지만, 본 발명에서는 과일은 사용하지 않고 경엽(莖葉)만을 사용한다.Snakeberry (Dakchesnea indica Focke) is a perennial herb of the Duchesnea sp. In the Rosaceae. It is poisonous and detoxified by the immature fruits and foliage of the snake. It is a medicinal herb that is used for (解毒), haekai (止咳), carcinoma, and yanghaemocarcinoma. Fruit is toxic and effective in the treatment of menstrual abnormalities. In the present invention, only fruit is used without using fruit.
방가지풀(학명: Sonchus Oleraceus L.)은 국화과(Compositae)에 속하는 2년생 초본으로 경엽(莖葉)을 사용하며 주성분은 카로틴, 아스코르빈산, 인베르타제(invertase), 코린(choline)등이며 치루, 위비(胃痺), 장벽(腸癖), 무독(無毒), 안심(安心), 경신(輕身), 강력(强力), 명목(明目) 및 오장의 사기(邪氣)를 제거하고 종기들을 치료하는데 사용되는 약재이다.The herbaceous herb (Sonchus Oleraceus L.) is a two-year-old herb belonging to the genus Compositae, which uses foliage, and its main components are carotene, ascorbic acid, invertase, and choline. It removes chewy, stomach, barrier, non-toxic, peace of mind, godliness, strength, nominal, and fraud. It is a medicine used to treat boils.
은조롱(학명: Cynancium wifordii Hemsuby)은 박주가리과 아스크레피아데시에(Asclepiadaceae)에 속하는 다년생 덩굴초인 뿌리덩이를 사용하며 주성분은 코데틴(caudatin)이며 면역조절, 항종양, 무독(無毒), 구병(久病), 허약(虛弱), 빈혈(貧血), 소년백발(白髮), 요슬강력(腰膝强力), 신경쇠약, 노인성변비에 사용되는 약재이다.Cynancium wifordii Hemsuby is a perennial vine that is a perennial vine that belongs to Asclepiadaceae.久病, weakness (빈), anemia (貧血), boy white hair (白髮), muscle strength (腰膝 强力), nervous breakdown, aging constipation is used in the medicine.
가시오가피(학명: Acanthopanax senticosus Rupr)는 오갈피나무과에 속한 낙엽소관목인 가시오가피 및 동식물의 근피 혹은 수피를 사용하며 주성분은 세스민(sesmin), 사브닌(savnin), 아드피오젠스(adpiogens) 등이며 간장(肝腸)과 신장(腎臟)에 작용하며 근육과 골격을 강장하거나, 하기명목(下氣暝目)에 사용되는 약재이다.Acanthopanax senticosus Rupr is a deciduous shrub belonging to the acanthopanax family.肝腸) and kidney (신장) acts to strengthen the muscles and skeleton, or the medicine used in the following name (下 氣 暝 目).
이 외에 추가로 오리나무(학명: Alnus japonicus Sieb), 갈화(학명: Pueraria thunbergiana Benth), 골쇄보, 양강 등이 골다공증, 관절통 및 관절염의 치료약재로 사용된다. 이들 약초는 다른 약재들의 효능을 보강 또는 향상시키는 역할을 하는 것이다.In addition, alders (Alnus japonicus Sieb), browning (Peraria thunbergiana Benth), bone clavicle, and Yang yang are used to treat osteoporosis, arthralgia and arthritis. These herbs serve to enhance or enhance the efficacy of other herbs.
본 발명은 상기의 재료들을 적절히 이용하여 아래와 같은 방법으로 골다공증, 관절통 및 관절염 치료제를 제조하는 것이다.The present invention is to prepare a therapeutic agent for osteoporosis, arthralgia and arthritis in the following manner using the above materials as appropriate.
첫째 단계 : 재료혼합단계First step: material mixing step
전체 중량에 대하여, 화목, 복숭아를 각각 10∼20%, 길핵, 복분자, 뱀딸기를 각각 8∼15%, 방가지풀, 은조롱, 가시오가피, 오리나무를 각각 6∼12%, 갈화, 골쇄보, 양강을 각각 5∼10%로 계량하여 혼합하고, 이 혼합된 약재무게의 약8배에 달하는 물을 첨가하는 단계이다.For the total weight, 10-20% of the flowers and peaches, 8-15% of the yeast nucleus, the bokbunja and the strawberry berries, 6-12% of the twigs of the grass, silver gourds, thorns, and alders, respectively, Yanggang is weighed and mixed at 5 to 10%, respectively, and about 8 times the weight of the mixed medicinal herbs is added to this step.
상기 재료들은 적절한 시기에 채취해야만 약효가 있고 또한 각 재료들은 각각 적당한 법제를 거쳐야만 약효가 있게 된다. 상기 재료들의 혼합비는 골다공증, 관절통, 관절염에 대하여 최대 효과가 나타나도록 수많은 실험을 통하여 얻어진 것으로 각 재료의 함량이 상기 혼합비를 벗어날 경우에는 치료효과가 현저하게 떨어지거나 효과가 전혀 없을 수도 있다.These materials are only effective when collected at the appropriate time, and each of the materials is only effective after proper legislation. The mixing ratio of the materials was obtained through numerous experiments to maximize the effect on osteoporosis, arthralgia, arthritis. When the content of each material is out of the mixing ratio, the therapeutic effect may be significantly lowered or ineffective.
둘째 단계 : 가열단계Second step: heating step
전 단계에서 만들어진 혼합물을 용기에 넣어 밀봉하고, 일반 한약을 달이는 온도로 가열하여 용기 내의 온도가 약65-85℃가 되고 또한 용기 내의 압력이 약 2기압이 되는 상태를 2-4시간 유지시킨다.The mixture made in the previous step is sealed in a container, and heated to a temperature for the general medicine, and maintained for 2-4 hours in which the temperature in the container is about 65-85 ° C. and the pressure in the container is about 2 atmospheres.
이 단계에서는 재료가 타거나 눌지 않도록 화력과 물의 양을 조절하는 것이 중요하다. 여기서 상기온도보다 높은 온도에서 달이게 되면 압력이 높아지게 되고 약재를 달이는 시간은 줄어들지만 유효성분이 파괴되어 손실되고, 상기온도보다 낮은 온도에서 달이게 되면 혼합물의 유효성분이 완전하게 추출되지 않으므로 온도 조절을 적절히 해야한다. 약재를 달이는 용기로서는 스텐레스 스틸로 된 이중 용기인 탕전기 (중간부위에 파라핀 내재)를 사용하는 것이 바람직하다.At this stage, it is important to control the amount of fire and water so that the material does not burn or crush. Here, when the temperature is higher than the above temperature, the pressure increases and the time for decoction is reduced, but the active ingredient is destroyed and lost. When the temperature is lower than the above temperature, the active ingredient of the mixture is not completely extracted, so temperature control is appropriately performed. Should be. As a container for dispensing medicines, it is preferable to use a water heater (paraffin embedded in the middle), which is a double container made of stainless steel.
셋째 단계 : 추출단계Third step: extraction step
전 단계에서 가열되어 달여진 혼합물을 여과하여 골다공증, 관절통 및 관절염 치료제를 완성시키는 단계이다. 이 과정에서의 추출방법은 종래 달인 한약을 여과하여 추출하는 방법들을 모두 적용시킬 수 있으나, 본 발명은 고압상태로 가열하는 것이기 때문에, 이 압력을 이용하여 용기 내의 액체를 용출 시키는 방법을 적용할 수도 있다.In the previous step, the heated and sweetened mixture is filtered to complete the treatment for osteoporosis, arthralgia and arthritis. The extraction method in this process can be applied to all methods of filtering the traditional decoction herbal medicine, but because the present invention is heated to a high pressure state, it is also possible to apply a method of eluting the liquid in the container using this pressure have.
상기의 단계를 거쳐서 최종적으로 얻어진 골다공증, 관절통 및 관절염 치료제는 황갈색을 띄는 액체이고 약간 씁쓸한 한약 맛이 난다. 이렇게 만들어진 본 발명의 골다공증, 관절통 및 관절염 치료제의 사용방법은 1회 복용량을 100∼150㎖로 하여 하루에 3회 복용하는 것이다.The treatment for osteoporosis, arthralgia and arthritis, finally obtained through the above steps, is a yellowish brown liquid with a slightly bitter herbal taste. The method of using the therapeutic agent for osteoporosis, arthralgia and arthritis of the present invention thus made is to take 3 times a day with a dose of 100-150ml.
본 발명에 사용되는 약재들은 각각 골다공증이나 관절의 염증에 어느 정도 효과가 있는 것이다. 그러나, 많은 실험결과, 본 발명은 사용되는 각각의 한약재 성분들을 서로 조화시켜 보완, 상승되는 효과를 가져오게 한 것으로서 각각의 한약재를 독립적으로 사용했을 때 보다 골다공증, 관절통, 관절염에 현저히 우수한 효과를 가져오는 것을 알 수 있었다.The medicines used in the present invention are each effective to some extent in osteoporosis or inflammation of the joints. However, as a result of many experiments, the present invention is to harmonize each of the medicinal herb ingredients used to complement and increase the effect, which is significantly better than osteoporosis, arthralgia, arthritis than when using each medicinal herb independently I could see it coming.
이하 본 발명을 실시 예에 의거하여 설명한다.Hereinafter, the present invention will be described based on Examples.
(실시예 1)(Example 1)
화목 15중량%, 복숭아12중량%, 길핵, 복분자 및 뱀딸기를 각각 10중량%, 방가지풀과 은조롱을 각각 8중량%, 가시오가피와 오디나무를 각각 6중량%, 갈화, 골쇄보 및 양각을 각각 5중량%하여 혼합한 약재의 혼합물 400g에 물32ℓ에 첨가하여 스텐레스 스틸로 된 이중용기인 탕전기에 넣고 65~85℃의 온도로 용기의 압력이 2기압 되게 조절하여 3시간 달인 후, 그 달여진 액체를 추출하여 골다공증, 관절통 및 관절염 치료제를 제조하였다.15% by weight of lumber, 12% by weight of peach, 10% by weight of yeast nucleus, bokbunja and snakeberry, 8% by weight of wild grass and silver gourd respectively, 6% by weight of thorny thorn and mulberry tree 400 g of the mixture of 5% by weight of each mixture was added to 32 liters of water, put in a double bowl made of stainless steel, and then placed in a double container made of stainless steel. The decoction liquid was extracted to prepare osteoporosis, arthralgia and arthritis treatments.
(실시예 2)(Example 2)
상기 실시 예1에서 제조된 골다공증, 관절통 및 관절염 치료제를 이용하여 15명의 골다공증과 관절통을 모두 앓고 있는 환자를 대상으로 임상 실험하였다. 실험대상은 40~70세로 다양하였으며, 실험방법은 실시예 1에서 제조된 골다공증과 관절통 및 관절염 치료제를 1회 120㎖씩 1일 3회 식전 30분에 복용하는 것을 3개월 간 지속하였다.Using osteoporosis, arthralgia and arthritis treatment agents prepared in Example 1, a clinical trial was conducted in 15 patients suffering from both osteoporosis and arthralgia. The test subjects ranged from 40 to 70 years, and the experimental method was continued for 3 months of taking osteoporosis, arthralgia and arthritis treatment agents, prepared in Example 1, 120ml once three times a day for 30 minutes before meals.
그 결과, 치료제를 복용한지 3주가 지나자 대부분의 환자들에게 통증이 현저히 떨어지는 것을 확인 할 수 있었고 2개월이 지난 후에는 모든 환자가 약간의 불편함은 있으나 관절통으로 부터 오는 큰 장애는 없는 것을 확인 할 수 있었다. 3개월 복용 후 골밀도를 조사한 결과 초기에 비해 골다공 증상이 현저히 떨어짐을 확인 할 수 있었다.As a result, after three weeks of treatment, most patients noticed a significant drop in pain. After two months, all patients had some discomfort but no major discomfort from joint pain. Could. After taking 3 months of bone mineral density, it was confirmed that the osteoporosis symptoms were significantly lower than the initial level.
그리고, 대상자들의 혈액을 채취, 백혈구 수를 조사하여 확인한 결과, 본 발명의 치료제를 복용하기 전에 비하여 관절염이 현저히 떨어짐을 알 수 있었다.In addition, as a result of collecting blood of the subjects and checking the white blood cell count, it was found that arthritis was remarkably decreased compared to before taking the therapeutic agent of the present invention.
상기 실시예에서 알 수 있듯이, 본 발명은 골밀도를 높이고 관절통을 완화시키며 관절염을 치유시킬 수 있는 것이다. 또한 본 발명의 의한 골다공증, 관절통 및 관절통 치료제는 여러종류의 한약재를 조합하여 각 한약재가 갖고 있는 유효성분들이 조화를 이루도록 함으로써 약의 효능이 훨씬 향상되고 화학요법이나 합성 의약품이 초래할 수 있는 부작용의 우려가 없다는 장점이 있다.As can be seen in the above embodiment, the present invention is to increase the bone density, relieve joint pain and heal arthritis. In addition, the osteoporosis, arthralgia and joint pain treatment according to the present invention by combining a variety of herbal medicines to ensure that the active ingredients of each herbal medicine to improve the efficacy of the drug much more and the fear of side effects that can be caused by chemotherapy or synthetic medicines There is no advantage.
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| JP2000053576A (en) * | 1998-08-06 | 2000-02-22 | Morishita Jintan Kk | Agent for prevention and treatment of postmenopausal osteoporosis containing herb plant as active component |
| KR20000019867A (en) * | 1998-09-16 | 2000-04-15 | 정세영 | Composition comprising the extract of drynaria fortunei j. sm. for promoting the regeneration of hard tissues |
| JP2000191542A (en) * | 1998-12-25 | 2000-07-11 | Lion Corp | Preventive/therapeutic agent for osteoporosis |
| KR20000054394A (en) * | 2000-06-03 | 2000-09-05 | 신준식 | Pharmacolocial effect and extracting method for chronic osteoporosis and degenerative bone marrow diseases and rhematoid arthritis treatment by constituent drugs of oriental medicine |
| KR20010045276A (en) * | 1999-11-04 | 2001-06-05 | 장인순 | Use of Duchesnea chrysantha herb extract as an antioxidant |
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2000
- 2000-12-13 KR KR1020000075878A patent/KR20010067023A/en not_active Application Discontinuation
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| KR960009908A (en) * | 1994-09-29 | 1996-04-20 | 김남규 | Peach Fermented Beverage |
| KR19980020871A (en) * | 1996-09-12 | 1998-06-25 | 이웅열 | Calcium supplement containing herbal medicine and its manufacturing method |
| JP2000053576A (en) * | 1998-08-06 | 2000-02-22 | Morishita Jintan Kk | Agent for prevention and treatment of postmenopausal osteoporosis containing herb plant as active component |
| KR20000019867A (en) * | 1998-09-16 | 2000-04-15 | 정세영 | Composition comprising the extract of drynaria fortunei j. sm. for promoting the regeneration of hard tissues |
| JP2000191542A (en) * | 1998-12-25 | 2000-07-11 | Lion Corp | Preventive/therapeutic agent for osteoporosis |
| KR19990083970A (en) * | 1999-09-03 | 1999-12-06 | 정진호 | Phamaceutical compositions for treating rheumatism and method for production thereof |
| KR20010045276A (en) * | 1999-11-04 | 2001-06-05 | 장인순 | Use of Duchesnea chrysantha herb extract as an antioxidant |
| KR20000054394A (en) * | 2000-06-03 | 2000-09-05 | 신준식 | Pharmacolocial effect and extracting method for chronic osteoporosis and degenerative bone marrow diseases and rhematoid arthritis treatment by constituent drugs of oriental medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100406124B1 (en) * | 2001-03-30 | 2003-11-15 | 주식회사 태평양 | Skin whitening cosmetic formulations co-containing melanogenesis inhibitors and UV B irradiation- induced prostaglandin synthesis inhibitors in skin cells |
| KR20040016752A (en) * | 2002-08-19 | 2004-02-25 | 파진바이오 주식회사 | Calcium supplements containing red ginseng, red ginseng, thorny cucumber, pomegranate and safflower seeds for osteoporosis |
| WO2008007880A1 (en) * | 2006-07-14 | 2008-01-17 | Industry-Academic Cooperation Foundation, Yonsei University | A composition comprising an extract of prunus persica (l.) batsch for treating and preventing bone diseases |
| KR100823354B1 (en) * | 2006-07-14 | 2008-04-17 | 연세대학교 산학협력단 | A composition comprising an extract of Prunus persica L. Batsch for treating and preventing bone disease |
| JP2009091276A (en) * | 2007-10-05 | 2009-04-30 | Pola Chem Ind Inc | Composition for bone ageing inhibition |
| US9549958B2 (en) | 2011-04-29 | 2017-01-24 | Industrial Technology Research Institute | Extracts of Cynanchum sp. and active ingredients contained therein in use of arthritis treatment |
| KR101362003B1 (en) * | 2011-12-23 | 2014-02-12 | 정숙연 | Manufacturing method of medicine for massage |
| KR101502465B1 (en) * | 2013-10-15 | 2015-03-13 | 한국 한의학 연구원 | A pharmaceutical composition comprising Alpinia Officinarum extracts for prevention and treatment of bone diseases or anti-vascular calcification activity |
| KR101678960B1 (en) * | 2015-07-29 | 2016-11-23 | 한국식품연구원 | Composition for preventing and treatment of osteoporosis |
| GB2558275A (en) * | 2016-12-23 | 2018-07-11 | Naturex Sa | Compositions |
| US11219657B2 (en) | 2016-12-23 | 2022-01-11 | Naturex Sa | Method for treating or preventing inflammation |
| CN108434417A (en) * | 2018-05-02 | 2018-08-24 | 黄舒君 | A kind of Chinese medicine composition and the preparation method and application thereof for treating pain |
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