KR20010041868A - Skin moisturizing compositions - Google Patents

Abstract

The present invention relates to a method for improving skin moisturizing and / or skin hydration, and more particularly, a method for improving the skin's absorption and / or adsorption capacity for water.

Description

Skin moisturizing composition {SKIN MOISTURIZING COMPOSITIONS}

Physiologically, the skin consists of an outer cell layer called the stratum corneum, the subcutaneous epidermal layer and the dermis. The stratum corneum, which varies in thickness from about 15 microns for the face and back of the hand to 500 microns for the soles and palms, plays an important role in regulating the moisture level in the skin. It contains keratinized cells, natural moisturizing factors and lipids. Together these functions act as a moisturizing barrier to retain moisture in the skin and also as a protective coating.

In the epidermal region below the stratum corneum, skin cells change from the normal living cell structure to the keratinized layer of keratin. During this change, some proteins, especially involucrin, crosslink and become the envelope of the stratum corneum cells. These cells contain keratin, which is also produced in the epidermis and, when supplied with water, provides flexibility to the stratum corneum. Other proteins, especially filaggrins, are broken down into products located in the stratum corneum cells and act as natural moisturizing compounds. Below the epidermal layer is the normal dermis of the skin, which mammals water and transports water to the epidermal part.

Water is very important for proper physical conditions and skin appearance. Dry, firm skin is usually the result of insufficient water levels in the stratum corneum. Without adequate moisture levels in the stratum corneum, a smooth, supple, elastic, healthy skin cannot be maintained.

The moisture level in the skin depends on many factors. Among them are the water binding capacity of the stratum corneum, the rate of water supply to the inner layer of the stratum corneum, and the rate of water loss on the outer surface of the skin. In view of these factors, the researchers have been actively studying methods to maintain the appropriate skin moisture levels over the years.

Conventional methods of maintaining water in the skin have included the use of occlusive agents. Occlusion agents are hydrophobic substances that promote moisture retention by forming a barrier on the skin that prevents water loss. The most commonly used occlusion agents include petrolatum, lanolin, cocoa butter, mineral oil and silicone.

Despite such conventional skin moisturizing methods, there is still a need for skin moisturizing products that moisturize the skin by mechanisms other than occlusion. The present inventors have found that the vitamin B ₃ compound is effective for moisturizing or hydrating the skin by improving water absorption into the stratum corneum or water absorption into the stratum corneum. In particular, it has been found that vitamin B ₃ compounds enhance the production of stratum corneum cell envelopes, stratum corneum keratin, natural moisturizing factor precursors (pilaggrin), and natural moisturizing factors that promote the ability of the skin to take up and bind water.

Therefore, it is an object of the present invention to provide a method of moisturizing the skin.

Another object of the present invention is to provide a method for improving the water adsorption capacity and / or absorption capacity of the skin by applying a safe effective amount of the composition containing a vitamin B ₃ compound.

All objects will be readily apparent from the following detailed description.

[Overview of invention]

The present invention moisturizes the skin by topically applying a safe and effective amount of a skin care composition containing the following to improve the water absorption and / or adsorption capacity of mammalian skin, especially the epidermis and more particularly the stratum corneum of mammalian skin. Or to a method of hydration.

A. Water adsorption or water absorption enhancer selected from the group consisting of vitamin B ₃ compounds and mixtures thereof; And

B. Dermatologically acceptable carrier for the vitamin B ₃ compound.

The present invention also contains from about 0.1 to about 40% of the vitamin B ₃ compound in the package of the skin care composition, together with information and / or instructions regarding the use of the vitamin B ₃ compound to enhance skin hydration or hydration. An article of manufacture comprising a skin care composition.

Unless otherwise indicated, all percentages and ratios herein are by weight of the total composition. All weight percentages are by weight of active unless otherwise indicated. All measurements are made at about 25 ° C. unless otherwise specified. As used herein, the terms "moisture", "moistured", "hydration" or "hydration" are broadly used to obtain a smoother and more flexible skin when recognized by visual and / or tactile and / or sensory evaluation, By dry, flaky, scaly, hard, itchy skin. The term "absorb" or "absorb" as used herein broadly means that water is absorbed into the skin, in particular the epidermis, more particularly the stratum corneum. As used herein, the term “adsorb” or “adsorption” broadly means that water is adsorbed to the proteins of the skin, especially the epidermis, more particularly to the stratum corneum. As used herein, the term “safely effective amount” means a good benefit, preferably a good skin appearance or feel benefit, an amount sufficient to significantly induce any benefit disclosed herein irrespective of it, provided that it is small enough to avoid serious side effects, That is, the amount that provides the person with a reasonable benefit of the risk ratio within the normal judgment area.

The present invention relates to a method of improving skin hydration or skin hydration, and more particularly, to a method of improving water absorption and / or adsorption capacity of skin.

The skin moisturizing composition of the present invention may consist principally of the essential ingredients and the limitations of the invention described herein, also additional or optional ingredients, or the limitations described herein.

Essential Ingredients: Vitamin B ₃ Ingredients

The composition of the present invention contains a safe effective amount of a natural or synthetic vitamin B ₃ compound. The composition of the present invention is preferably from about 0.01 to about 50% by weight, more preferably more than 1% to about 50%, more preferably more than 2% to about 40%, even more preferably more than about 5% to about 30%, most preferably greater than about 10% to about 20% of a vitamin B ₃ compound.

As used herein, "vitamin B ₃ compound" means a compound having the formula :, derivatives thereof, and salts of any of the foregoing.

Wherein R is -CONH ₂ (ie niacinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinyl alcohol)].

Examples of derivatives of the vitamin B ₃ compound include nicotinic acid esters such as non-vascular expanding nicotinic acid esters, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides and niacinamide N-oxides.

Suitable nicotinic acid esters include nicotinic acid esters of alcohols having 1 to 22 carbon atoms, preferably 1 to 16 carbon atoms, more preferably 1 to 6 carbon atoms. Alcohols are suitably straight or branched, cyclic or acyclic, saturated or unsaturated (including aromatic), and substituted or unsubstituted. The ester is preferably a non-rubifacient. As used herein, "non-red cargo" means that after applying the desired composition to the skin, the esters typically do not exhibit a noticeable flushing reaction (such compounds can cause vasodilation that is invisible to the naked eye). Even so, most people will not experience a noticeable flush reaction). Alternatively, nicotinic acid material that reddens at higher doses may be used in smaller doses where no reddening reaction occurs. Non-redning nicotinic acid esters include, but are not limited to, tocopherol nicotinate and inositol hexanicotinate, of which tocopherol nicotinate is preferred.

Another derivative of the vitamin B ₃ compound is a derivative of niacinamide obtained from substitution of one or more of the amide group hydrogens. Non-limiting examples of niacinamide derivatives useful herein include, for example, nicotinyl amino acids obtained from the reaction of activated nicotinic acid compounds (e.g. nicotinic acid azide or nicotinyl chloride) with amino acids, and organic carboxylic acids (e.g. C ₁ Nicotinyl alcohol esters of C ₁₈ ). Specific examples of the derivatives include nicotinuric acid and nicotinyl hydroxamic acid having the following chemical structures:

Nicotinuric acid:

Nicotinyl Hydroxamic Acid:

Examples of nicotinyl alcohol esters include nicotinyl alcohol esters such as carboxylic acid, salicylic acid, acetic acid, glycolic acid, palmitic acid and the like. Other non-limiting examples of vitamin B ₃ compounds useful herein include 2-chloronicotinamide, 6-aminonicotinamide, 6-methylnicotinamide, n-methylnicotinamide, n, n-diethylnicotinamide, n- ( Hydroxymethyl) -nicotinamide, quinolinic acid imide, nicotinanilide, n-benzylniconinamide, n-ethylnicotinamide, nifenazone, nicotinaldehyde, isoninicotinic acid, methyl isnicotinic acid, thioninicotinamide, nialamide , 1- (3-pyridimethyl) urea, 2-mercaptonnicotinic acid, nicomol and niaprazine.

Examples of such vitamin B ₃ compounds are known in the art and include many sources such as Sigma Chemical Company (St. Louis, MO); ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, WI).

One or more vitamin B ₃ compounds can be used herein. Preferred vitamin B ₃ compounds are niacinamide and tocopherol nicotinate. Niacinamide is more preferred.

In use, it is preferred that the salts, derivatives and salt derivatives of niacinamide have substantially equivalent efficacy to niacinamide in the methods of regulating the skin condition described herein.

Salts of vitamin B ₃ compounds are also useful here. Non-limiting examples of salts of vitamin B ₃ compounds useful herein include organic or inorganic salts, such as inorganic salts with anionic inorganic species (eg chlorides, bromides, iodides, carbonates, preferably chlorides), and Organic carboxylic acid salts (mono-, di- and tri C ₁ -C ₁₈ carboxylates such as acetates, salicylates, glycolates, lactates, malates, citrates, preferably monocarboxyls such as acetates) Acid salts). All of the various salts of vitamin B ₃ compounds, including those described above, can be readily prepared by those skilled in the art, and are described, eg, in W. Wenner, "The Reaction of L-Ascorbic and D-Isoascorbic Acid with Nicotinic Acid and Its Amide", J. Organic Chemistry, VOL. 14, 22-26 (1949). Wenner describes the synthesis of ascorbates of niacinamide.

In a preferred embodiment, the cyclic nitrogen of the vitamin B ₃ compound is substantially chemically free (eg, unbound and / or impaired), or substantially chemically free after delivery to the skin (“chemically free”) Is referred to hereinafter as " nonincendant "). More preferably, the vitamin B ₃ compound is essentially uncomplexed. Therefore, if the composition contains a vitamin B ₃ compound in salt or other complexing form, such a complex is preferably substantially reversible and more preferably essentially reversible when the composition is delivered to the skin. For example, such complexes should be substantially reversible, at pH about 5.0 to about 6.0. Such reversibility can be readily determined by those of ordinary skill in the art.

More preferably, the vitamin B ₃ compound is substantially uncomplexed in the composition prior to delivery to the skin. Examples of methods for minimizing or preventing the formation of undesirable complexes include the exclusion of substances that form substantially irreversible or other complexes with vitamin B ₃ compounds, pH adjustment, ionic strength adjustment, the use of surfactants, and Formulations in which the substance forming the complex and the vitamin B ₃ compound are in different phases are included.

Thus, in a preferred embodiment, the vitamin B ₃ compound contains a limited amount of salt form, more preferably substantially free of salts of the vitamin B ₃ compound. Preferably, the vitamin B ₃ compound contains less than about 50% of the salts, more preferably essentially free of salt form. Vitamin B ₃ compounds in compositions having a pH of about 4 to about 7 usually contain less than about 50% salt form.

Vitamin B ₃ compounds may be included as substantially pure substances or as extracts obtained by appropriate physical and / or chemical isolation from natural sources (eg, plants). The vitamin B ₃ compound is preferably substantially pure or more preferably essentially pure.

Without being bound by theory, it is believed that vitamin B ₃ compounds vaporize skin hydration or hydration by a variety of different mechanisms. One mechanism involves the effect of vitamin B ₃ compounds on natural moisturizing factors. Natural moisturizing factors include skin proteins, especially water-binding metabolite byproducts of filaggrin. Vitamin B ₃ compounds are believed to increase the level of natural moisturizing factors and thereby moisturize by increasing the level of the skin protein. Another mechanism relates to the effect of vitamin B ₃ compounds on the level and / or molecular weight of keratin proteins in the stratum corneum. The protein combines with water to help provide flexibility for the keratinocyte layer. Thus, increased keratin levels increase the level of moisture-binding protein, thereby improving skin moisturization. The skin moisturization achieved is also related to the type of keratin present. Keratin proteins of higher molecular weight (ie, molecular weight greater than-) tend to bind more water. A third mechanism is related to the effect of vitamin B ₃ compounds on the levels of involuclin and collagen (glue) proteins. Involuclin is a protein precursor to keratinocyte envelopes that encompass keratin proteins and natural moisturizing factors. Collagen proteins are closely related to the stratum corneum cell envelope and help to connect stratum corneum cells. Increased involuclin and collagen protein levels enhance and enhance skin moisturization by helping to augment and enhance keratinocyte envelopes and delay the dehydration of the covered keratin and natural moisturizing factors.

carrier

Another essential ingredient of the present invention is a dermatologically acceptable carrier. The expression "dermatologically acceptable carrier" as used herein means that the carrier is suitable for topical application to the skin, has excellent aesthetic properties, is compatible with the actives and all other ingredients of the present invention, It does not cause inadequate safety or toxicity problems. The safe effective amount of the carrier is about 50 to about 99.99%, preferably about 99.99 to about 80%, more preferably about 98 to about 90%, most preferably about 95 to about 90% of the composition.

The carrier can be in a wide variety of forms. For example, emulsion carriers are useful herein, including emulsions in oil-in-oil, oil-in-water, oil-in-oil-in-water and silicone-in-water-in-oil forms and the like. These emulsions may have a wide range of viscosities, such as about 100 to about 200,000 cps. These emulsions may also be delivered in the form of a spray using a mechanical pump container or a pressurized aerosol container using conventional propellers. These carriers can be delivered in the form of a whipped cream (mouse). Other suitable topical carriers include anhydrous liquid solvents such as oils, alcohols and silicones (eg mineral oils, ethanol, isopropanol, dimethicone, cyclomethicone, etc.); Aqueous-based single phase liquid solvents (eg hydro-alcoholic solvent systems); And said anhydrous and aqueous-based single phase solvents in a thickened manner (e.g., the viscosity of the solvent is increased to form a solid or semisolid by adding appropriate gums, resins, waxes, polymers, salts, etc.). . Examples of topical carrier systems useful in the present invention are described in the following four references, all of which are incorporated herein by reference: ["Sun Products Formulary" Cosmetics & Toiletries, vol. 105, pp. 122-139 (December 1990); "Sun Products Formulary, Cosmetics & Toiletries, vol. 102, pp. 117-136 (March 1987); USP 4,960,764 (October 2, 1990, Figueroa et al.) And USP 4,254,105 (March 3, 1981, March 3, Fukuda et al.).

The carrier of the skin care composition may comprise from about 50 to about 99 weight percent of the composition of the present invention, preferably from about 75 to about 99%, most preferably from about 85 to about 95%.

Preferred cosmetic and / or pharmaceutically acceptable topical carriers include hydro-alcoholic and oil-in-water emulsions. If the carrier is hydro-alcoholic, the carrier may contain about 0 to about 99% of ethanol, isopropanol or mixtures thereof, and about 1 to about 99% of water. More preferred are carriers containing about 5 to about 60% ethanol, isopropanol or mixtures thereof, and about 40 to about 95% water. Especially preferred are carriers containing about 20 to about 50% of ethanol, isopropanol or mixtures thereof, and about 50 to about 80% of water. If the carrier is an oil-in-water emulsion, the carrier may comprise any of the common excipient components for preparing the emulsion. A more detailed description of suitable carriers is given in USP 5,605,894 (Blank et al.) And USP 5,681,852 (Bissett), all of which are incorporated by reference herein.

Random ingredient

The moisturizing composition of the present invention may optionally comprise a film former or a substantivity enhancer. Film formers or firmness enhancing agents of the present invention are generally resins or organic polymers which are insoluble in the carrier and which enhance the firmness of the vitamin B ₃ compound by forming a relatively thin film on the skin during carrier evaporation. Film formers or firmness enhancing agents can be natural or synthetic. Suitable film formers or firmness enhancing agents include, but are not limited to, polyvinyl alcohol, ethyl cellulose, methoxy cellulose, hydroxyethyl cellulose, nitrocellulose, gum beegum, polyvinylpyrrolidone, vinyl pyrrolidone / Vinyl acetate copolymers, copolymers of eicosene and vinyl pyrrolidone (an example of which is sold by Ganex.RTM.V-220 by GAF Chemical Corporation), vinyl acetate / unsaturated carboxylic acid copolymer, methyl meta Terpolymers of acrylate / stearyl methacrylate / dimethylaminoethyl methacrylate, terpolymers of vinyl acetate / allyl stearate / allyloxyacetic acid, and maleic anhydride / methyl vinyl ether copolymers such as “Gantrez AN” Those commonly referred to, also the ethyl, isopropyl and butyl esters of the above copolymers, and maleic anhydride / butyl vinyl ether Le copolymers are included.

Plasticizers are preferably added to the composition to impart flexibility to the polymer film. Suitable plasticizers include, but are not limited to, polyethylene glycol, polyoxyethylene propylene glycol, polyoxypropylene glycol, polyoxyethylene polyoxypropylene block copolymers, glycerin and various vegetable oils such as cottonseed oil, palm oil, rapeseed oil, sunflower oil, casters Yu etc. are included. In preparing and inspecting film forming copolymers, the rate of active release from the polymer film is known to depend on the nature of the plasticizer used. Hydrophobic plasticizers, such as vegetable oil, inhibit the release rate of the active substance, while hydrophilic substances such as polyoxypropylene glycol, polyethylene glycol and polyoxyethylene tend to enhance the release rate of the active substance from the film.

The moisturizing composition of the present invention may optionally contain additional skin actives. Non-limiting examples of such skin actives include hydroxy acids such as salicylic acid; Epidermal release agents such as zwitterionic surfactants; Sunscreens such as 2-ethylhexyl-p-methoxycinnamate, 4,4'-t-butylmethoxydibenzoyl-methane, octocrylene, phenyl benzimidazole sulfonic acid; Sunblock agents such as zinc oxide and titanium dioxide; Anti-inflammatory agents; Antioxidants / radical scavengers such as tocopherol and esters thereof; Metal chelating agents, in particular iron chelating agents; Retinoids such as retinol, retinyl palmitate, retinyl acetate, retinyl propionate and retinal; N-acetyl-L-cysteine and derivatives thereof; Hydroxy acids such as glycolic acid; Keto acids such as pyruvic acid; Benzofuran derivatives; And skin protectants. Mixtures of any of the above skin actives may also be used. A more detailed description of these actives is given in USP 5,605,894 (Blank et al.), Cited above by reference. Preferred skin actives include hydroxy acids such as salicylic acid, sunscreens, antioxidants and mixtures thereof.

Other conventional skin care product additives may also be included in the compositions of the present invention. For example, urea, guanidine, glycerol, petrolatum, mineral oil, sugar esters and polyesters, polyolefins, methyl isostearate, ethyl isostearate, cetyl ricinoleate, isononyl isononanoate, isohexadecane, lanolin , Lanolin esters, cholesterol, pyrrolidone carboxylic acid / salts (PCA), trimethyl glycine (betaine), tranexamic acid, amino acids (eg serine, alanine) and / or salts thereof, panthenol and derivatives thereof, Collagen, hyaluronic acid, elastin, hydrolyzate, primrose oil, jojoba oil, epidermal growth factor, soy saponin, mucopolysaccharides, and mixtures thereof can be used. Other suitable additives or skin actives are described in more detail in PCT application WO 97/39733 (Oblong et al., Published October 30, 1997), which is incorporated herein by reference.

Preparation of Skin Moisturizing Composition

Compositions of the present invention are generally prepared by conventional methods known in the art for preparing topical compositions. Such methods typically involve mixing the components in one or more steps in a relatively uniform state, with or without heating, cooling, vacuum application, or the like. Non-limiting examples of product forms can be gels, emulsions, lotions, creams, liquids, solutions, ointments, and the like.

Skin moisturizing method

The method of the invention moisturizes or hydrates the skin of a mammal (especially human skin, in particular human facial skin and body skin, more particularly human hands, feet and facial skin), in particular the epidermis, more particularly the stratum corneum of the mammal. Useful for The method of moisturizing or hydrating the skin of the present invention includes topically applying a safe effective amount of the skin moisturizing or hydrating composition of the present invention to the skin. The amount of application, frequency of application and duration of use can vary widely depending on the level of the vitamin B ₃ compound and / or other components of a given composition, and the level of moisturizing or hydration desired. However, to achieve the moisturizing or hydrating benefits of the present invention, the skin moisturizing or hydrating composition is applied such that the minimum amount of a constant vitamin B ₃ compound on the skin is about 0.001 to about 1 mg / cm ² . As used herein, the term "constant" means that the concentration of vitamin B ₃ compound on the skin does not vary by more than about 20%, preferably by more than about 10%, over a minimum of about 1 to 12 hours do.

In a preferred embodiment, the composition is continuously applied to the skin (ie, reapplied even at times such as after washing). “Continuous topical application” means for the life of the subject, preferably for at least about 1 week, more preferably at least about 2 weeks, even more preferably at least about 1 month, even more preferably at least about 3 months , Even more preferably for at least about 6 months, even more preferably for at least about 1 year, over an extended period of time. If after several maximum periods of use (eg 5, 10 or 20 years), the benefits can be achieved, it is desirable to continue the continuous application for the life of the object, to maintain and / or increase the achieved benefits. Typically, the application may be applied from about 1 to about 4 times a day for the extended period, but may be applied more than 4 times a day, especially when used on body parts that are washed several times a day, such as face and hands. .

A wide range of amounts of the compositions of the present invention can be used to provide skin appearance and / or tactile benefits. The amount of the composition normally applied in one application is the composition mg / skin cm ² , from about 0.1 to about 10 mg / cm ² . A particularly useful dosage is about 1 to about 4 mg / cm ² , and a particularly useful dosage is about 2 mg / cm ² .

Adjusting the skin condition is preferably in the form of skin lotions, creams, cosmetics, etc. (ie, "leave-on" which can be left on the skin for some aesthetic, prophylactic, therapeutic or other benefit. ) "Composition). After the composition has been applied to the skin and prior to removal by washing or the like, preferably at least about 5 minutes, more preferably at least about 20 minutes, even more preferably at least about 1 hour, most preferably at least several hours, such as about Leave on the skin for up to 12 hours.

Another approach for continuous exposure of the skin to at least a minimum level of vitamin B ₃ compound is to apply the compound using a patch. Such an approach is particularly useful for problem skin areas that require more intensive treatment. The patch may be occluded, semi-occluded or non-occluded. The vitamin B ₃ compound composition may be contained in the patch or may be applied to the skin before applying the patch. The patch may also include additional actives such as chemical initiators for exothermic reactions, such as those described in PCT application WO 9701313 (Burkett et al.). Preferably, the patch is applied in night treatment form, at night (eg on the face).

The following examples illustrate and demonstrate embodiments within the scope of the invention. The embodiments are capable of many modifications without departing from the spirit and scope of the invention, and therefore, the embodiments are merely illustrative and are not to be regarded as limiting of the invention.

Example 1

The following is an example of a skin cream incorporating the composition of the present invention. Using conventional techniques, the components of each column are combined and mixed to form a composition, and then applied from about 0.5 to about 50 g to the skin.

Component weight%

Glycerin 6.933

Niacinamide 5.000

Permethyl 101A ¹ 3.000

Sepigel ² 2.500

Q2-1403 ³ 2.000

Isopropyl Isostearate 1.330

Arlatone 2121 ⁴ 1.000

Cetyl Alcohol CO-1695 0.720

SEFA Cotonate ⁵ 0.670

Tocopherol Acetate 0.500

Panthenol 0.500

Adol 62 ⁶ 0.480

Kobo Titanium Dioxide 0.400

Sodium Hydroxide 50% 0.0125

Mercury

Fiery 5 ⁷ 0.150

Disodium EDTA 0.100

Glydant Plus ⁸ 0.100

Myrj 59 ⁹ 0.100

Emersol 132 ¹⁰ 0.100

Colorant 0.00165

Purified water balance 100

Example 2

The following is an example of a skin cream incorporating the composition of the present invention. The composition of each column is combined and mixed using conventional techniques to form a composition, and then applied to the skin of about 0.5 to about 50 g.

Component weight%

Glycerin 6.933

Tocopherol Nicotinate 2.000

Permethyl 101A ¹ 3.000

Sepigel ² 2.500

Q2-1403 ³ 2.000

Isopropyl Isostearate 1.330

Arlatone 2121 ⁴ 1.000

Cetyl Alcohol CO-1695 0.720

SEFA Cotonate ⁵ 0.670

Tocopherol Acetate 0.500

Panthenol 0.500

Adol 62 ⁶ 0.480

Kobo Titanium Dioxide 0.400

Sodium Hydroxide 50% 0.0125

Mercury

Fiery 5 ⁷ 0.150

Disodium EDTA 0.100

Glydant Plus ⁸ 0.100

Myrj 59 ⁹ 0.100

Emersol 132 ¹⁰ 0.100

Colorant 0.00165

Purified water balance 100

Example 3

The following is an example of a skin cream incorporating the composition of the present invention. The composition of each column is combined and mixed using conventional techniques to form a composition, and then applied to the skin of about 0.5 to about 50 g.

Component weight%

Glycerin 6.933

Niacinamide 2.000

Permethyl 101A ¹ 4.000

Q2-1403 ³ 2.000

Isopropyl Isostearate 1.330

Arlatone 2121 ⁴ 1.000

Cetyl Alcohol CO-1695 0.720

SEFA Cotonate ⁵ 0.670

Carbopol 954 ¹¹ 0.500

Tocopherol Acetate 0.500

Panthenol 0.500

Adol 62 ⁶ 0.480

Kobo Titanium Dioxide 0.400

Sodium Hydroxide 50% 0.250

Mercury

Fiery 5 ⁷ 0.150

Disodium EDTA 0.100

Glydant Plus ⁸ 0.100

Myrj 59 ⁹ 0.100

Emersol 132 ¹⁰ 0.100

Carbopol 1382 ¹² 0.100

Colorant 0.00165

Purified water balance 100

1.Isohexadecane, Presperse Inc. South Plainfield, NJ

2. Polyacrylamide (and) C _13-14 Isoparaffin (and) Lauret-7, Seppic Corporation, Fairfield, NJ

3. Dimethicone (and) Dimethiconol, Dow Corning Corp., Midland, MI

4. Sorbitan monostearate and sucrocoate, ICI Americas Inc., Wilmington, DE

5. Sucrose esters of fatty acids, Procter and Gamble, Cincinnati, OH

6. Stearyl Alcohol, Procter and Gamble, Cincinnati, OH

7.Fiery 5 n / a, Procter and Gamble, Cincinnati, OH

8.DMDM Hydantoin (and) Iodopropyl Butylcarbamate, Lonza Inc., Fairlawn, NJ

9.PEG-100 Stearate, ICI Americas Inc., Wilmington, DE

10.Stearic acid, Henkel Corp., Kankakee, IL

11.Carbomer, BF Goodrich, Cleveland OH

12.Carbomer, BF Goodrich, Cleveland OH

Claims (10)

A method of adsorbing or absorbing water in mammalian skin by applying a safe effective amount of a skin care composition, comprising: A. Water adsorption or water absorption enhancer selected from the group consisting of vitamin B ₃ compounds and mixtures thereof; And B. Dermatologically acceptable carrier for the vitamin B ₃ compound. The method of claim 1 wherein water adsorption or absorption is achieved by increasing the concentration level of skin protein selected from the group consisting of filaggrin, keratin, involukrin and mixtures thereof. The method of claim 1 or 2, wherein the concentration of the adsorption or absorption enhancer is greater than 5%. The method of claim 1, wherein the vitamin B ₃ compound is selected from niacinamide, derivatives of niacinamide, non-vascular expanding esters of nicotinic acid, and mixtures thereof. The method according to any one of claims 1 to 4, wherein the composition further contains additional skin actives selected from hydroxy acids, epidermal release agents, sunscreens, antioxidants, retinoids and mixtures thereof. The compound according to any one of claims 1 to 5, wherein the hydroxy acid is salicylic acid; Epidermal release agents are selected from zwitterionic surfactants and mixtures thereof; The sunblock agent is selected from zinc oxide, titanium dioxide and mixtures thereof; Sunscreens are selected from 2-ethylhexyl-p-methoxycinnamate, 4,4'-t-butylmethoxydibenzoyl-methane, phenyl benzimidazole sulfonic acid, octocrylene and mixtures thereof; Antioxidant is selected from tocopherols, esters thereof and mixtures thereof; The retinoid is selected from retinol, retinyl acetate, retinyl propionate and mixtures thereof. A method of moisturizing or hydrating mammalian skin by applying a safe effective amount of a skin care composition, comprising: a. Safe effective amount of one or more vitamin B ₃ compounds; And b. Cosmetically acceptable carrier To maintain a minimum concentration of 0.001 to 1 mg / cm ² of vitamin B ₃ compound on the skin. 8. The method of any one of claims 1 to 7, wherein the minimum concentration of vitamin B ₃ compound on the skin is achieved by repeated application of the dermal composition. The method of claim 1, wherein the skin care composition further contains a film former or a substantivity enhancer. An article of manufacture comprising a skin care composition containing from 0.1 to 40% of a vitamin B ₃ compound in a package of said skin care composition, with information and / or instructions.