JPH062659B2 - Skin cosmetics - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a skin cosmetic composition containing niceritrol, and more specifically, it continuously promotes blood circulation in the skin to activate skin tissue and retain water in the skin. The present invention relates to a skin cosmetic which enhances the function and exhibits a beautiful skin effect.

(Prior Art) Conventionally, in order to maintain a healthy and beautiful skin, it has been performed to blend a skin moisturizer with a hydrophilic skin moisturizer and an oily skin softener that give appropriate water and oil content to the skin cosmetics. There is.

Skin moisturizers include glycerin, propylene glycol,
Polyethylene glycol, pyrrolidone carboxylate, etc. are used, but these may absorb water in the stratum corneum, which is the outermost layer of the skin, and may cause loss of skin water. The skin cosmetics contained in (1) were not always satisfactory, such as giving a strange feeling such as stickiness.

Liquid paraffin, petrolatum, olive oil, squalane, lanolin, synthetic ester oil, etc. are used as skin softeners, but these should also be contained in skin cosmetics to the extent that they prevent water evaporation from the epidermis sufficiently. Occasionally, it had drawbacks such as inhibiting normal metabolism of the skin (disclosure of the invention). In view of the above-mentioned drawbacks found in skin moisturizers and skin softeners, the By not only relying on the hydration of the epidermis by the physical action of the compounding agent or the prevention of water evaporation from the epidermis, by activating the skin tissue and continuously enhancing the water retention function originally possessed by the skin As a result of earnest research for the purpose of providing a skin cosmetic that maintains or restores the skin in a healthy state,
A skin cosmetic prepared by incorporating niceritrol, which is a derivative of nicotinic acid, exhibits an effect that meets the purpose, and further, has a wettability (moist feeling), softness (smooth feeling), elasticity and gloss. The present invention has been completed by finding that it has a skin-beautifying effect of giving

(Object of the Invention) The object of the present invention is to retain the water content of the skin (effect of improving rough skin,
It is intended to provide a skin cosmetic excellent in keratin improving effect, moisturizing effect) and beautiful skin effect.

(Structure of the Invention) The present invention is a skin cosmetic material containing niceritrol.

(Specific Description of Structure) Niceritrol used in the present invention is a known substance,
It has been applied to improve hyperlipidemia as a drug having an excellent serum lipid lowering action.

The chemical properties and the like of niceritrol are as follows.

(1) Structure (2) Chemical name: Pentaerythritol tetranicotinate (3) Molecular formula: C ₂₉ H ₂₄ N ₄ O ₈ (4) Molecular weight: 556.54 (5) Melting point: 162-165 ° C. Skin cosmetics of the present invention After being absorbed into the skin, niceritrol, which is to be blended with, gradually produces free nicotinic acid by the action of esterase, and expresses a continuous blood circulation promoting action without skin irritation. Inferred.

The blending amount of niceritrol is preferably in the range of 0.05 to 1.0 wt% based on the total amount of the skin cosmetic (composition). If the blending amount is less than 0.05 wt%, the effect is not sufficiently achieved, while
Even if it exceeds 1.0 wt%, the improvement of the effect commensurate with the increase cannot be expected.

The skin cosmetics of the present invention include, for example, lotions, emulsions,
It can be applied to creams, packs and the like.

In addition to the above, a colorant, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant and the like can be appropriately added to the skin cosmetic of the present invention within the range where the object of the present invention is achieved.

(Examples) Hereinafter, the present invention will be described in detail based on examples and comparative columns.

The skin blood flow rate test method, the moisturizing effect test method, the rough skin improving effect test method, the keratin improving effect test method, and the sensory test (beautiful skin effect test method) are as follows.

(1) Skin blood flow test method 3 New Zealand White rabbits were shaved on the abdomen,
After being fasted for 18 hours, pentabarbitol sodium salt is intravenously injected at a rate of 35 mg / kg for anesthesia. A plate-type transducer was fixed on the sample application site (test site) on the abdomen with cellophane tape, and a cross thermoelectric skin blood flow meter (Shin-Ai Co., Ltd., 201
Skin blood flow (μV) is measured using a (type).

Blood flow sample was uniformly applied to 0.1g to the skin site of 3 × 2 cm, and a predetermined time after the sample application blood flow before sample application (C _B) (e.g. 0.5, 1.0, 2.0 hours later) ( Ct) is measured, and the blood flow increase rate (%) is calculated by the following formula.

The test results are shown by the average value of the blood flow increase rate of 3 birds.

The increase in blood flow is found to be about 5 to 20% even when the cream base for skin cosmetics is applied as a sample, but when a sample containing a component with a remarkable blood circulation promoting effect is applied, The rate of increase is as high as 40 to 80%.

(2) Rough skin improving effect test method 20 middle-aged and elderly subjects having rough skin on the lower legs were tested for the effect of continuous application for 4 weeks. Approximately 1 g of the sample was applied to the left lower leg test site of the test subject once a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria.
The lower right leg was not coated with the sample and served as a control.

Criteria for skin dryness −: Normal ±: Minor dryness, no desquamation +: Dryness, mild desquamation ++: Dryness, moderate desquamation +++: Dryness, desquamation prominent Compare the judgment results of the test site before and after the test, When skin dryness is improved by two or more stages (for example, + →-,
++ → ±) is valid, and if it is improved by one step, it is somewhat valid,
When there was no change, it was invalidated. The test results were shown by the number of subjects who were valid or slightly valid.

(3) Keratin improvement (increased keratinocyte anti-exfoliation) effect test method Scotch tape (Nichiban Mending Tape) on the skin of the test area before and after the disclosure of the rough skin improvement measurement test described above
Was adhered, and the state of keratinocytes attached to the tape when peeled off was examined in detail with a scanning electron microscope, and the skin keratinocyte anti-peeling property was analyzed according to the following criteria, and the keratin improving effect was obtained. Keratin improving effect (increased keratinocyte anti-exfoliation)
Judgment criteria Evaluation score 1 No scale is recognized 2 Small scale is scattered 3 Small to medium scale is significant 4 Large scale is significant Evaluation is that the difference between the evaluation score of the test site after continuous application for 4 weeks and that of the control site is 2 or more. The case was set as valid, the case of 1 point was set as slightly valid, and the case of 0 point was set as invalid. The judgment results are shown by the number of subjects who were valid and slightly valid.

(4) Moisturizing effect test method Before and after the start of the rough skin improving effect test, the skin conductance value (unit: micromho) of the test site of each subject was measured by an impedance meter (IBS, IBS).
-354 type).

It is generally recognized that the higher the skin conductance value, the lower the electric resistance of the skin and the higher the keratin water content of the skin.

The moisturizing effect was evaluated from the rate of increase in keratin water content (%) calculated by the following formula.

W ₀ : Conductance value of the sample application site before the start of the test W: Conductance value of the sample application site at the end of the test The test results are shown as the average value of the keratin water increase rate of 20 test subjects.

(5) Sensory test (Beautiful skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 3 months was evaluated. The test results are shown by the number of people who responded that moisturized skin, smoothed skin, and tense skin were generated for each item of wettability, smoothness, and elasticity of the skin.

Examples 1 to 4 and Comparative Examples 1 to 4 [Two-layer skin lotion] Each skin was prepared by blending a two-layer skin lotion base with nicotinic acid and a derivative thereof as described in the first embodiment. A lotion was prepared and the above tests were carried out.

In the skin blood flow test, the rate of increase in blood flow was measured 0.5, 1.0, and 2.0 hours after application of the sample.

(1) Composition (2) Preparation method After the components (A) and (B) are uniformly dissolved, the component (A) and the component (B) are mixed with stirring and dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Properties The results of various tests of each two-layer type skin lotion are shown in the right column of Table 1.

As shown in Table 1, those containing the bases of the skin lotions of Comparative Examples 1 to 4 and the conventionally known nicotinic acid, methyl nicotinate, and nicotinic acid amide have a low blood flow increase rate or time. The blood flow rate of increase was decreased with the passage of time. Further, Comparative Examples 2 and 3 had skin irritation, and the test on human skin was impossible.

The skin cosmetics of the present invention of Examples 1 to 4 clearly showed good results in all tests.

In Examples 1 to 4, skin irritation did not occur in various tests on human skin.

Examples 5-7, Comparative Examples 5-7 [Skin cream] Similar to Example 1, each skin cream was prepared with the following composition, and various tests were carried out. The results are shown in the right column of Table 1. .

(1) Composition (2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C, mixed, and cooled to 30 ° C with stirring to prepare each skin cream.

(3) Properties As shown in Table 1, the skin creams of Examples 5 to 7, which are the skin cosmetics of the present invention, show a continuous increase rate of blood flow and various tests as compared with Comparative Examples 5 to 7. The excellent effect is shown, and the compounding amount of niceritrol is 0.05 ~ 1.0wt%
Within the range, the object of the present invention can be achieved.

(Effects of the Invention) As described above, the present invention is excellent in skin water retention function (rough skin improving effect, keratin improving effect, moisturizing effect) and beautiful skin effect (sensory test), and also has low skin irritation. It is clear to provide cosmetics.

Claims (1)

[Claims] 1. A skin cosmetic composition containing niceritrol.