JPH062660B2 - Skin cosmetics - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a skin cosmetic containing nicomethate citrate, and more specifically, it promotes continuous blood circulation in the skin,
The present invention relates to a skin cosmetic which activates skin tissues and enhances the water retention function of the skin to exhibit a beautiful skin effect.

(Prior Art) Conventionally, in order to maintain a healthy and beautiful skin, it has been performed to blend a skin moisturizer with a hydrophilic skin moisturizer and an oily skin softener that give appropriate water and oil content to the skin cosmetics. There is.

Skin moisturizers include glycerin, propylene glycol,
Polyethylene glycol, pyrrolidone carboxylate, etc. are used, but these may absorb water in the stratum corneum, which is the outermost layer of the skin, and may cause loss of skin water. The skin cosmetics contained in (1) were not always satisfactory, such as giving a feeling of strangeness such as stickiness.

Liquid paraffin, petrolatum, olive oil, squalane, lanolin, synthetic ester oil, etc. are used as skin softeners, but these should also be contained in skin cosmetics to the extent that they prevent water evaporation from the epidermis sufficiently. At times, it had a defect such as a cause of inhibiting normal metabolism of the skin.

DISCLOSURE OF THE INVENTION In view of the above-mentioned drawbacks of skin moisturizers and skin softeners, the inventors of the present invention only provide water replenishment to the epidermis or prevention of water evaporation from the epidermis by the physical action of these compounding agents. To provide a skin cosmetic that maintains the skin in a healthy state or repairs it by activating the skin tissue and continuously enhancing the water retention function originally possessed by the skin, rather than depending on it. As a result of intensive research aimed at
A skin cosmetic composition containing nicotinic acid citrate, which is a derivative of nicotinic acid, exhibits an effect meeting the purpose,
Furthermore, they have found that they have a beautiful skin effect of imparting wettability (moisturization), flexibility (smoothness), elasticity and gloss to the skin, and completed the present invention.

(Object of the Invention) The object of the present invention is to retain the water content of the skin (effect of improving rough skin,
It is intended to provide an excellent skin cosmetic having a keratin improving effect, a moisturizing effect, and a beautiful skin effect (sensory test).

(Structure of the Invention) The present invention is a skin cosmetic composition containing nitricate citrate.

(Detailed Description of Configuration) Nicamate citrate used in the present invention is a known substance, and is applied to the improvement of hypertension as a drug having an excellent peripheral blood flow increasing action.

The chemical properties and the like of nicomethate citrate are as follows.

(1) Structure (2) Chemical name: 2-diethylam-inoethyl nicotinate citr
ate) (3) Molecular formula: C ₁₈ H ₂₆ O ₉ N ₂ (4) Molecular weight: 414.42 (5) Melting point: 115.5 to 116.5 ° C. Nicamethaate citrate that can be incorporated into the skin cosmetic composition of the present invention is excessively transdermally absorbed. Since it has a sex, it maintains an effective concentration of the drug in the epidermis and dermis, has little skin irritation, and is assumed to exhibit a continuous blood circulation promoting action.

The blending amount of nicomethate citrate is preferably in the range of 0.05 to 1.0 wt% based on the total amount of the skin cosmetic (composition). If the blending amount is less than 0.05 wt%, the effect is not sufficiently achieved, while if it exceeds 1.0 wt%, the improvement of the effect commensurate with the increase cannot be expected.

The skin cosmetics of the present invention include, for example, lotions, emulsions,
It can be applied to creams, packs and the like.

In addition to the above, a colorant, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant and the like can be appropriately added to the skin cosmetic of the present invention within the range where the object of the present invention is achieved.

(Examples) Hereinafter, the present invention will be described in detail based on examples and comparative columns.

The skin blood flow rate test method, the moisturizing effect test method, the rough skin improving effect test method, the keratin improving effect test method, and the sensory test (beautiful skin effect test method) are as follows.

(1) Skin blood flow test method 3 New Zealand White rabbits were shaved on the abdomen,
After being fasted for 18 hours, pentabarbitol sodium salt is intravenously injected at a rate of 35 mg / kg for anesthesia. Fix the back of the rabbit, fix the plate-type transducer on the sample application site (test site) on the abdomen with cellophane tape, and use a cross thermoelectric stack type skin blood flow meter (Shinei Co., Ltd., Shinkoda 201 type) The skin blood flow (μV) is measured.

Samples were uniformly coated with the 0.1g to the skin site of 3 × 2 cm, blood flow (Ct blood flow before sample application (C _B) and a predetermined time after the sample application (0.5, 1.0, 2.0 hours after) ) Is measured, and the blood flow increase rate (%) is calculated by the following formula.

The test results are shown by the average value of the blood flow increase rate of 3 birds.

The increase in blood flow is found to be about 5 to 20% even when the cosmetic cream base is applied as a sample, but when the sample containing a component having a remarkable blood circulation promoting effect is applied, the increase in blood flow is 40%. The rate of increase is as high as ~ 80%.

(2) Rough skin improving effect test method 20 middle-aged and elderly subjects having rough skin on the lower legs were tested for the effect of continuous application for 4 weeks. About 1 g of the sample was applied to the left lower leg test site of the test subject once a day, and the skin condition before and after the start of the test was judged according to the following judgment criteria. The lower right leg was not coated with the sample and served as a control.

Criteria for skin dryness −: Normal ±: Minor dryness, no desquamation +: Dry, mild desquamation ++: Dry, moderate desquamation +++: Dryness, remarkable desquamation Compare the determination results of the test site before and after the test, When skin dryness is improved by two or more stages (for example, + →-,
++ → ±) is valid, and if it is improved by one step, it is somewhat valid,
When there was no change, it was invalidated. The test results were shown by the number of subjects who were valid or slightly valid.

(3) Keratin improvement (increased keratinocyte anti-exfoliation) effect test method Scotch tape (Nichiban Mending Tape) on the skin of the test area before and after the disclosure of the rough skin improvement measurement test described above
Was adhered, and the state of keratinocytes attached to the tape when peeled off was examined in detail with a scanning electron microscope, and the skin keratinocyte anti-peeling property was analyzed according to the following criteria, and the keratin improving effect was obtained. Keratin improving effect (increased keratinocyte anti-exfoliation)
Judgment criteria Evaluation score 1 No scale is recognized 2 Small scale is scattered 3 Small to medium scale is significant 4 Large scale is significant Evaluation is that the difference between the evaluation score of the test site after continuous application for 4 weeks and that of the control site is 2 or more. The case was set as valid, the case of 1 point was set as slightly valid, and the case of 0 point was set as invalid. The judgment results are shown by the number of subjects who were valid and slightly valid.

(4) Moisturizing effect test method Before and after the start of the rough skin improving effect test, the skin conductance value (unit: micromho) of the test site of each subject was measured by an impedance meter (IBS, IBS).
-354 type).

It is generally accepted that the higher the skin conductance value, the lower the electric resistance of the skin and the higher the keratin water content of the skin.

The moisturizing effect was evaluated from the rate of increase in keratin water content (%) calculated by the following formula.

W ₀ : Conductance value of the sample application site before the start of the test W 〃 〃 At the end 〃 The test results are shown as the average value of the rate of increase in keratin water content of 20 subjects.

(5) Sensory test (Beautiful skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 3 months was evaluated. The test results are shown by the number of people who responded that moisturized skin, smoothed skin, and tense skin were generated for each item of wettability, smoothness, and elasticity of the skin.

Examples 1 to 4 and Comparative Examples 1 to 4 [Two-layer type skin lotion] A two-layer type skin lotion having the following composition was formulated with nicotinic acid and its derivative as shown in Table 1. A skin lotion was prepared and the above-mentioned tests were carried out.

In the skin blood flow test, 0.5, 1.0,
The rate of increase in blood flow was measured after 2.0 hours.

(1) Composition (2) Preparation method (B) component, citrate nicametate is dissolved in the (C) component, other components are dissolved in the (A) component, (A), (C) component to each uniform Dissolved. Next, the components (A) and (C) are mixed, stirred and dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Characteristics The results of various tests of each two-layer type skin lotion are shown in the right column of Table 1.

As shown in Table 1, those containing the skin lotion bases of Comparative Examples 1 to 4 and the conventionally known nicotinic acid, methyl nicotinate, and nicotinic acid amide have a low blood flow increase rate or a long time. The rate of increase in blood flow decreased with time. Further, Comparative Examples 2 and 3 had skin irritation, and the test on human skin was impossible.

The skin cosmetics of the present invention of Examples 1 to 4 clearly showed good results in all tests.

In Examples 1 to 4, skin irritation did not occur in various tests on human skin.

Examples 5-7, Comparative Examples 5-7 [Skin cream] Similar to Example 1, each skin cream was prepared with the following composition, and various tests were carried out. The results are shown in the right column of Table 1. .

(1) Composition (2) Preparation method The component (B) was added in the same manner as in Example 1 and Comparative Examples 2 to 3.
It was dissolved in the component (A) or the component (C), and the components (A) and (C) were dissolved by heating at 80 ° C. Then, the components (A) and (C) were mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics As shown in Table 1, the skin creams of Examples 5 to 7, which are skin cosmetics of the present invention, show a sustained blood flow increase rate as compared with Comparative Examples 5 to 7 and various characteristics. Shows excellent effect in the test, the blending amount of nitricate citrate is 0.05-1.
The object of the present invention can be achieved within the range of 0 wt%.

(Effects of the Invention) As described above, the present invention is excellent in skin water retention function (rough skin improving effect, keratin improving effect, moisturizing effect) and beautiful skin effect (sensory test), and also has low skin irritation. It is clear to provide cosmetics.

Claims (1)

[Claims] 1. A skin cosmetic composition comprising nicomethate citrate.