CN1292680A - Skin moisturizing compositions - Google Patents

Skin moisturizing compositions Download PDF

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Publication number
CN1292680A
CN1292680A CN998036811A CN99803681A CN1292680A CN 1292680 A CN1292680 A CN 1292680A CN 998036811 A CN998036811 A CN 998036811A CN 99803681 A CN99803681 A CN 99803681A CN 1292680 A CN1292680 A CN 1292680A
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China
Prior art keywords
skin
vitamin
composition
chemical compound
compositions
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CN998036811A
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Chinese (zh)
Inventor
D·L·比赛特
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Procter and Gamble Ltd
Procter and Gamble Co
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Procter and Gamble Ltd
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Publication of CN1292680A publication Critical patent/CN1292680A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

The present invention relates to methods of improving skin moisturization or skin hydration, and more specifically, to methods improving the skin's absorptive and/or adsorptive capacity for water.

Description

Skin moisturizing compositions
The invention technical field
The present invention relates to improve the method for skin moisturizing or skin hydration effect, in more detail, relate to and improve skin the absorption of water and/or the method for adsorption capacity.
Background of invention
From angle of physiology, form by cuticular ectoderm, following epidermal area and corium by being called for skin.Cuticular thickness difference, about 15 microns 500 microns of being changed on sole and the palm on facial and the back of the hand, horny layer plays an important role in the humidity of controlling skin.It is made up of keratinocyte, nature moisturizing factor and lipids, and all these functions are together as the protective finish that keeps humidity in the skin, and moisture barrier.
Be arranged in subcuticular epidermis district, Skin Cell has experienced from normal living cells structure and has changed to cuticular cuticular layer.In this variation, the envelope of crosslinked keratinize confluent monolayer cells takes place in some protein, especially involurin.These cells contain keratin, and keratin also produces in epidermis, and play the function that the horny layer flexibility is provided when hydration.Other protein, especially nature moisturizing factor precursor (filaggrin) resolve into the product that is arranged in corneocyte and play a role as the natural moisture preserving chemical compound.Be normal dermis of skin below epidermal area, it keeps moisture and transmits moisture to the epidermis district.
Water is extremely important for the normal physical state and the outward appearance of skin.The skin of drying and be full of cracks is mainly owing to humidity in the horny layer causes inadequately.In horny layer, lack under the condition of suitable humidity, can not keep soft, pliable and tough, elasticity, healthy skin.
Humidity level in the skin is depended on many factors.Speed that cuticular water supplies water in conjunction with potential, to cuticular internal layer is arranged and from the speed of skin appearance face dehydration in these factors.For many years, consider these factors, research worker is always in the method for actively seeking the suitable humidity level who keeps such in the skin.
Keep the traditional method of humidity of skin to comprise the use plugging agent.Plugging agent is to promote the hydrophobic substance that moisture keeps by form the barrier layer that prevents moisture loss on skin.The plugging agent of normal use comprises petrolatum, lanoline, cocoa butter, mineral oil and polysiloxanes.
Although there is so traditional skin moisture-keeping method, but still need make the skin moisture-keeping product of skin hydration by the mechanism that is different from obstruction.The inventor has now found that, vitamin B 3Chemical compound by improving water on the horny layer absorption or horny layer in the absorption of water provide moisture or hydration to skin effectively.Specifically, have now found that vitamin B 3Chemical compound has improved the formation of corneocyte envelope, horny layer keratin, nature moisturizing factor precursor and nature moisturizing factor, and these have promoted the absorption of skin and the ability of bound water.
Therefore, an object of the present invention is to provide the method for skin moisture-keeping.
Another object of the present invention provides by using the vitamin B that contains of safe and effective amount 3Compound compositions is improved skin to the absorption of water and/or the method for absorptive capacity.
These purposes and other purpose will be easy to become apparent from following detailed description.
Summary of the invention
The present invention relates to improve particularly epidermis of mammal skin by the skin care compositions of the safe and effective amount of local application, the horny layer of the mammal skin of more particularly saying so is to the absorption of water and/or improve the method that thereby the absorptive capacity of water is made skin moisture-keeping or hydration, and this skin care compositions contains:
A. be selected from vitamin B 3The water absorption or the water absorption enhancer of chemical compound and composition thereof; With
B. be used for described vitamin B 3The dermatological acceptable carrier of chemical compound.
The invention further relates to and comprise skin care compositions and about using vitamin B 3Chemical compound improves the information of skin moisture-keeping or hydration and/or the goods of explanation, and described skin care compositions contains 0.1% to about 40% the vitamin B of having an appointment in the packing that is used for it 3Chemical compound.
Unless otherwise indicated, all percents used herein and ratio are the weight in whole compositions.Unless otherwise indicated, all wt percent is in active matter weight.Unless otherwise indicated, all measurements all are to carry out under about 25 ℃.Term used herein " is preserved moisture ", " preserving moisture ", " hydration " or " aquation " broadly are meant and handle or prevent skin exsiccant, flaky, flaky, tight, that itch to produce more level and smooth, the more softish skin that vision and/or sense of touch and/or feeling evaluation are discovered.Term used herein " absorption " or " Absorption " are meant that broadly water absorbs in the skin, especially absorb in the epidermis, more particularly absorb in the horny layer.Term used herein " absorption " or " adsorption " are meant that broadly water is adsorbed onto on the skin, especially are adsorbed onto on the protein of epidermis, more particularly are adsorbed onto on the horny layer.Term used herein " safe and effective amount " is meant that the amount of chemical compound or compositions is enough to significantly bring out positive beneficial effect, the preferred positive skin appearance or the beneficial effect of sensation, comprise beneficial effect disclosed herein independently, but enough low to avoid serious adverse, rational terrible ratio promptly is provided in those skilled in the art's correct determination range.
Detailed Description Of The Invention
Skin moisturizing compositions of the present invention can comprise neccessary composition of the present invention described here and restriction composition, and any additional or optional ingredients, component or restriction composition described here, perhaps is made up of them, perhaps is made up of them basically.
Necessary component vitamin B 3Component.
Compositions of the present invention comprises the natural of safe and effective amount or synthetic vitamin B 3Chemical compound.Compositions of the present invention preferably comprises about 0.01% to about 50%, more preferably greater than 1% to about 50%, further more preferably greater than 2% to about 40%, further more preferably greater than 5% to about 30%, most preferably greater than 10% to about 20% vitamin b 3 compound.
" vitamin B used herein 3Chemical compound " be meant chemical compound with following formula: Wherein R is-CONH 2(being nicotiamide) ,-COOH (being nicotinic acid) or-CH 2OH (being nicotinyl alcohol); Their derivant; With aforementioned in any salt.
Aforementioned vitamin B 3The exemplary derivant of chemical compound comprises that nicotinate (comprises non-vasodilation esters, the cigarette base aminoacid of nicotinic acid, nicotinyl alcohol esters, nicotinic acid N-oxide and the nicotinoyl amine n-oxide of carboxylic acid.
The nicotinate that is suitable for comprises C 1-C 22, preferred C 1-C 16, more preferably C 1-C 6The nicotinate of alcohol.Alcohol be suitably for straight or branched, ring-type or acyclic, saturated or unsaturated (comprising aromatic series) with replacement or unsubstituted.The preferred non-flushing of esters." non-flushing " used herein is meant, ester does not produce visible rubescent reaction (great majority among the ordinary people can not experience visible rubescent reaction, and the chemical compound of even now can cause the sightless vasodilation of bore hole) usually after being applied to skin with title composition.In addition, be that the nicotinic acid material of flushing can use than low dosage in higher dosage, under this dosage, do not produce flare reaction.The non-flushing ester of nicotinic acid includes but not limited to tocopheryl nicotinate and hexanicotinate; Preferred tocopheryl nicotinate.
Vitamin B 3Other derivant of chemical compound is that one or more amide groups hydrogen replace the nicotinamide derivates that forms.The limiting examples that is used for nicotinamide derivates of the present invention comprises cigarette base aminoacid, for example is derived from active nicotinic acid chemical compound (for example nicotinic acid azide or nicotinoyl chlorine) and amino acid whose reaction, and organic carboxyl acid (C for example 1-C 18) nicotinyl alcohol esters.The instantiation of such derivant comprises nitocinoylglycine and cigarette base hydroxamic acid, and they have the following chemical structure: nitocinoylglycine:
Figure 9980368100071
Cigarette base hydroxamic acid:
Figure 9980368100072
Exemplary nicotinyl alcohol esters comprises the nicotinyl alcohol esters of carboxylic acid salicylic acid, acetic acid, glycolic, Palmic acid etc.Be used for vitamin B of the present invention 3Other limiting examples of chemical compound is 2-chloro-nicotinamide, 6-aminonicotinamide, 6-methylnicotinamide, N-methylnicotinamide, N, nicamide, N-(methylol) nicotiamide, quinolinic acid imidodicarbonic diamide, N-nicotinanilide (nicotinanilide), N-benzyl nicotiamide, N-ethylnicotinamide, neopiran, nicotine aldehyde .gamma.-pyridinecarboxylic acid, methyl .gamma.-pyridinecarboxylic acid, Thionicotinamide, nialamide, 1-(3-pyridylmethyl) urea, 2-sulfydryl nicotinic acid, cholexamin and niaprazine.
Said vitamin B 3Examples for compounds is known in the art, can be purchased from many sources, for example Sigma chemical company (St.Louis, MO); ICN Biomedicals, Inc (Irvin, CA) and Aldrich chemical company (Milwaukee, WI).
Can use one or more vitamin Bs among the present invention 3Chemical compound.Preferred vitamin B 3Chemical compound is nicotiamide and tocopheryl nicotinate.More preferably nicotiamide.
In use, preferably those have the material with the identical effect of nicotiamide in the method for adjusting skin as herein described basically for the salt of nicotiamide, derivant and salt derivative.
Vitamin B 3The salt of chemical compound also is used for the present invention.Be used for vitamin B of the present invention 3The limiting examples of the salt of chemical compound comprises organic or inorganic salt, as the inorganic salt of inorganic anion form (for example, chloride, bromide, iodide, carbonate, preferred chloride) and organic carboxylate (comprise monobasic-, binary-and ternary-C 1-C 18Carboxylate, for example acetate, Salicylate, glycollate, lactate, malate, citrate, preferably unary carboxylation such as acetate).Vitamin B 3These and other salt of chemical compound can be prepared at an easy rate by those skilled in the art, for example, as W.Wenner in " reaction of L-ascorbic acid and D-arabo-ascorbic acid and nicotinic acid and amide thereof ", " organic chemistry journal " (J.Organic Chemistry), the 14th volume, described in the 22-26 (1949), this article is incorporated herein for reference.Wenner has described Ascorbate synthetic of nicotiamide.
In preferred embodiments, vitamin B 3The ring nitrogen of chemical compound is chemistry free (for example not in conjunction with and/or be not obstructed) basically, or becomes chemical basically free (" chemistry is free " is also referred to as " not complexation " hereinafter) after being transported to skin.Vitamin B 3Chemical compound more preferably is not complexation basically.Therefore, if compositions contains the vitamin B of salt or other form complexed 3Chemical compound, compositions one is transported on the skin, and such complex preferably is reversible basically, and more preferably essence is reversible.For example, such complex is about 5.0～about 6.0 should be reversible basically at pH.Those skilled in the art can determine such reversibility at an easy rate.
The more preferably vitamin B in compositions before skin is carried 3Chemical compound is not complexation on substantially.The exemplary method that reduces to greatest extent or prevent to form undesirable complex comprises: remove and vitamin B 3The material of irreversible basically or other complex of compound formation, regulate pH, regulate ionic strength, use surfactant and formulating (vitamin B wherein 3Chemical compound and be in not in the homophase with the material of its complexation).Such method is that those of ordinary skills know.
Therefore, in preferred embodiments, vitamin B 3Chemical compound contains limited amount salt form, more preferably is substantially free of vitamin B 3The salt of chemical compound.Preferred vitamin B 3Chemical compound contains and is less than such salt of about 50%, more preferably is substantially free of salt form.At pH is vitamin B in about compositions of 4～about 7 3Chemical compound contains usually and is less than about 50% salt form.
The vitamin B that comprises 3Chemical compound can be used as pure basically material, or as the extract that obtains by proper physical and/or chemistry segregation from natural origin (for example plant).Vitamin B 3Chemical compound preferably is pure basically, more preferably is pure in essence.
Bound by theory not it is believed that vitamin B 3Chemical compound strengthens skin moisture-keeping or hydration by several different mechanism.A kind of mechanism relates to vitamin B 3Chemical compound is to the influence of nature moisturizing factor.Nature moisturizing factor comprises the particularly metabolic by-product of the bound water of nature moisturizing factor precursor of skin protein.It is believed that vitamin B 3Chemical compound has improved the content of above-mentioned skin protein, thereby has improved the content of nature moisturizing factor.Therefore preserve moisture.Another kind of mechanism relates to vitamin B 3Chemical compound is to the influence of keratin Protein content and/or molecular weight in the horny layer, and these protein-bound waters also help to provide flexibility to the corneocyte layer.Keratin content increases, and has therefore improved the concentration of moisture conjugated protein, thereby has improved skin moisture-keeping.The skin moisture-keeping degree is also relevant with the keratin type that exists.The keratin protein of higher molecular weight (be molecular weight greater than-) is often in conjunction with more water.The third mechanism relates to vitamin B 3Chemical compound is to the influence of involurin and desmosome (desmosomal) Protein content.Involurin is the protein precursor of corneocyte envelope, and described envelope wraps up keratin protein and nature moisturizing factor.Desmosome protein and corneocyte envelope are combined closely, and help to connect corneocyte.The increase of involurin and desmosome protein content enlarges also and has strengthened the corneocyte envelope, helps the keratin that delays to be wrapped in and the dehydration layer of nature moisturizing factor, thereby improves skin moisture-keeping.
Carrier
Another kind of neccessary composition of the present invention is the dermatological acceptable carrier.Phrase used herein " dermatological acceptable carrier ", be meant that carrier is fit to be locally applied to skin, have good aesthetic properties,, and can not cause safety or the toxicity problem that any discomfort is worked as with active matter of the present invention and any other component compatibility.The safe and effective amount of carrier, in compositions, be about 50%～about 99.99%, preferred about 99.9%～about 80%, more preferably from about 98%～about 90%, most preferably from about 95%～about 90%.
Carrier can be a various forms.For example, emulsion carriers includes but not limited to: oil-in-water type, water-in-oil type, oil-in-water be water-in type and polysiloxanes Bao Shuizai oil-in emulsion again, is applicable among the present invention.These emulsions can covering wide range of viscosities, for example from about 100 centipoises to about 200,000 centipoises.These emulsions also can transmit with Sprayable with mechanical pumping container or with the pressurized aerosol container of conventional propellant.These carriers also can the mousse form transmit.Other topical carrier that is suitable for comprises on-aqueous liquid solvent such as oils, alcohols and polysiloxane-based (for example mineral oil, ethanol, isopropyl alcohol, polydimethylsiloxane, Cyclomethicone etc.); Water base single-phase liquid solvent (for example, water-alcohol solvent system); And the thickening form of these non-water and water base single-phase solvent (for example, the viscosity of solvent being increased to form solid or semisolid form) by adding suitable glue, resin, wax, polymer, salt etc.In following four pieces of documents, the example that is used for topical carrier system of the present invention has been described, the whole integral body of these documents are incorporated herein by reference: " sunscreen product formulary; " " cosmetics and toilet articles ", the 105th volume, 122-139 page or leaf (nineteen ninety December); " sunscreen product formulary ", " cosmetics and toilet articles ", the 102nd volume, 117-136 page or leaf (in March, 1987); The people's such as Figueroa that authorize October 2 nineteen ninety United States Patent (USP) 4,960,764; United States Patent (USP) 4,254,105 with the people such as Fukuda that authorized on March 3rd, 1981.
The content of the carrier of skin care compositions, in the weight of compositions of the present invention, can be for about 50% to about 99%, preferred about 75% to about 99%, and most preferably from about 85% to about 95%.
Preferred cosmetic and/or the acceptable topical carrier of materia medica comprise water-pure system and emulsion oil-in-water.When carrier was water-pure system, carrier can contain have an appointment 0%～about 99% ethanol, isopropyl alcohol or its mixture and about water of 1%～about 99%.More preferably carrier contains have an appointment 5%～about 60% ethanol, isopropyl alcohol or its mixture and about water of 40%～about 95%.Special preferred vector contains have an appointment 20%～about 50% ethanol, isopropyl alcohol or its mixture and about water of 50%～about 80%.When carrier was emulsion oil-in-water, carrier can contain the excipient composition any commonly used that is useful on these emulsions of preparation.The more detailed discussion of suitable carrier sees in the United States Patent (USP) 5,681,852 of people's such as Blank United States Patent (USP) 5,605,894 and Bissett, and two pieces of equal integral body of patent are incorporated herein for referencial use.
Optional components
Humidifying composite of the present invention can randomly contain film former or direct reinforcing agent (substantivity enhancer).Film former of the present invention or direct reinforcing agent normally can be dissolved in carrier and can form the film of relative thin in the carrier for evaporating process on skin, thereby strengthen vitamin B 3The organic polymer of the substantivity of chemical compound or resin.Film former or direct reinforcing agent can be natural or synthetic.The film former or the direct reinforcing agent that are suitable for include but not limited to: polyvinyl alcohol, ethyl cellulose, the methoxyl group cellulose, hydroxyethyl-cellulose, nitrocellulose, propolis, polyvinyl pyrrolidone, vinyl pyrrolidone/vinyl acetate copolymer, eicosylene and vinylpyrrolidone copolymers (one of them example can be purchased with Ganex.RTM.V-220 from GAF ChemicalCorporation), vinyl acetate/copolymers of unsaturated carboxylic acids, methyl methacrylate/methacrylic acid stearyl/dimethylaminoethyl acrylate methyl amino-ethyl ester terpolymer, the copolymer of vinyl acetate/stearic acid allyl ester/allyloxy acetate terpolymer and maleic anhydride/methyl ethylene ether copolymer such as commercial being called " Gantrez AN " and the ethyl of these copolymers, isopropyl and butyl ester, and maleic anhydride/butyl vinyl ether copolymer.
As required plasticizer is joined in the compositions to invest the polymeric film flexibility.The plasticizer that is suitable for includes but not limited to: Polyethylene Glycol, polyoxyethylene propylene glycol, polyoxypropylene glycol, polyoxyethylene polyoxypropylene block copolymer, glycerol and each vegetable oil such as Oleum Gossypii semen, Petiolus Trachycarpi oil rapeseed oil.Sunflower oil, Semen Ricini wet goods.In the preparation and test of film forming polymer, the speed that the known activity thing discharges from polymeric film depends on the character of used plasticizer.Hydrophobic plasticizer as vegetable oil, often hinder the rate of release of active substance, and water wetted material such as polyoxypropylene glycol, Polyethylene Glycol and polyoxyethylene often improves the rate of release of active substance from film.
Humidifying composite of the present invention can randomly contain other skin activity thing.The non-limiting example of such skin activity thing comprises hydroxy acid such as salicylic acid; Exfoliation agent such as zwitterionic surfactant; Sunscreen such as 2-ethylhexyl-right-Methoxycinnamate, 4,4 '-tert-butyl group methoxy dibenzoyl base-methane, octocrylene, Phenylbenzimidazolesulfonic acid; Daylight blocker such as zinc oxide and titanium dioxide; Antiinflammatory; Antioxidant/radical scavenger such as tocopherol and ester thereof; Metal-chelator is iron chelating agent particularly; Retinoid such as retinol, retinyl palmitate, retinyl acetate, Vitamin A propionate and retinal; N-acetyl group-L-cysteine and derivant thereof; Hydroxy acid such as glycolic; Keto acid such as acetone acid; Benzofuran derivatives; And shielding medicine for skin.Also can use the mixture of any above-mentioned skin activity thing.The more detailed description of these active matters is seen people's such as Blank United States Patent (USP) 5,605,894 (above having introduced for referencial use).Preferred skin activity thing comprises hydroxy acid such as salicylic acid, sunscreen, antioxidant and composition thereof.
Also can comprise the skin-protection product additive that other is conventional in the compositions of the present invention.For example, urea, guanidine, glycerol, vaseline, mineral oil, sugar ester and polyester (or polyester), polyolefin, the isostearic acid methyl ester, the isostearic acid ethyl ester, the ricinoleic acid cetyl ester, isononyl isononanoate, 2-Methylpentadecane, lanoline, the lanoline esters, cholesterol, 2-pyrrolidone-5-carboxylic acid/salt (PCA), trimethyl glycine (betanin), tranamic acid (transexamicacid), aminoacid (serine for example, alanine) and/or their salt, pantothenylol and derivant thereof, ossein, hyaluronic acid, elastin laminin matter, hydrolyzate, primrose oil, Jojoba oil, epidermal growth factor, Saponosides, soya, mucopolysaccharide and their mixture all can use.Other useful additives or skin activity thing have further detailed discussion in people's such as disclosed Oblong on October 30th, 1997 PCT application WO97/39733, introduce it for referencial use in full at this.
The preparation of skin moisturizing compositions
Compositions of the present invention normally prepares the method preparation of topical composition as known in the art with conventional method.Such method generally comprises in a step or multistep composition is mixed to relatively state uniformly, has or does not have heating, cools off, utilizes vacuum etc.The limiting examples of product form can be gel, emulsion, lotion, cream frost, liquid, solution, ointment etc.
The method of skin moisture-keeping
Method of the present invention is used for mammal skin (human body skin particularly, particularly people's face and body skin, more especially people's hand, shank and skin of face), particularly epidermis, the more especially cuticular humidification or the hydration of mammal skin.Skin moisturizing of the present invention or hydration process comprise skin moisturizing of the present invention or the hydration compositions to the safe and effective amount of topical application.The amount of application of compositions, frequency and life cycle are with the vitamin B in the given compositions 3Chemical compound and/or other components contents and required humidification or hydration levels and in wide region, change.Yet,, must use skin humidification or hydration compositions so that vitamin B on the skin to be provided in order to obtain the beneficial effect of humidification of the present invention or hydration 3Concentration, promptly constant minimum from about 0.001 milligram/centimetre 2To about 1 milligram/centimetre 2Be meant vitamin B on the skin at this used term " constant " 3The variation of the content of chemical compound is lower than least concentration and is no more than approximately 20% in about 1-12 hour time cycle, preferably be no more than about 10%.Constant level can be by to skin, particularly on the health in one day often position such as the face and the hands of washing, products applied and obtaining repeatedly.
In preferred embodiments, with compositions chronic administration (or use repeatedly, as after washing) in skin." long-term local application " is meant at the long-term in life continuous and local of subject and uses compositions, preferably about at least week age, more preferably about at least two time-of-weeks, further more preferably at least one month, further more preferably at least about three months, further more preferably at least about six months, further more preferably at least about one-year age.Although (for example 5 years, 10 years or 20 years) can obtain beneficial effect after different uses the most over a long time, preferably often use continuity subject all one's life, with the beneficial effect that keeps and/or enhancing is obtained.So over a long time in, uses and generally be about every day one, but application rate can surpass four times every day, particularly to being used on the health at one day often position such as the face and the hands of washing to about four times.
The compositions of the present invention of amount that can use wide region is to provide the beneficial effect of skin appearance and/or sensation.The amount of application that this compositions is used at every turn is in milligram compositions/centimetre 2 skins, about 0.1 milligram/centimetre 2To about 10 milligrams/centimetre 2Useful especially amount of application is about 1 milligram/centimetre 2To about 4 milligrams/centimetre 2, more useful especially amount of application is about 2 milligrams/centimetre 2
Regulate skin and preferably put into practice by the compositions of using forms such as skin lotion, cream frost, cosmetics, said composition should be stayed on the skin to produce some aesthetics, preventative, treatment or other beneficial effect (i.e. " retention " compositions).After compositions was applied to skin, preferably it stopped on skin at least about 5 minutes, more preferably at least about 20 minutes, and further more preferably at least about 1 hour, most preferably at least several hours, for example, reach about 12 hours, remove then, for example flush away.
Guarantee that skin is exposed to the vitamin B of minimum content at least continuously 3The another kind of method of chemical compound is by using patch to come administered compound.Such method is used in particular for the dermatopathy position that need more focus on.Patch can be inaccessible, the semi-closure plug or gas-pervious.Vitamin B 3Compound composition can be included in the patch, or is applied to skin before using patch.Patch also can contain other active matter such as people such as exothermic reaction chemical initiator such as Burkett those materials described in PCT application WO9701313.Preferred patch with night form of therapy use (for example, applying) on the face at night.
Embodiment
The following example has further specified and has described the embodiment in the scope of the invention, provides embodiment just in order to illustrate rather than limit the present invention, may not make many changes because do not depart from the scope and spirit of the present invention.
Embodiment 1
Be the embodiment that belongs to the skin ointment frost of the present composition below.Compositions forms every hurdle composition by using routine techniques in conjunction with also mixing, the amount with about 0.5 gram～about 50 grams is applied to skin then.
Composition % weight
Glycerol 6.933
Nicotiamide 5.000
Permethyl101A 1 3．000
Sepigel 2 2．500
Q2-1403 3 2．000
Isostearic acid isopropyl ester 1.330
Arlatone2121 4 1．000
Hexadecanol CO-1695 0.720
The cotton acid esters of SEFA 50.670
Tocopherol acetate ester 0.500
Pantothenylol 0.500
Adol62 6 0．480
Kobo titanium dioxide 0.400
Sodium hydroxide 50% 0.0125
Water
Fiery5 7 0．150
EDTA disodium 0.100
Glydant?Plus 8 0．100
Myrj59 9 0．100
Emersol132 10 0．100
Pigment 0.00165
Purified water adds to 100 in right amount
Embodiment 2
Be the embodiment that belongs to the skin ointment frost of the present composition below.Compositions forms every hurdle composition by using routine techniques in conjunction with also mixing, the amount with about 0.5 gram～about 50 grams is applied to skin then.
Composition % weight
Glycerol 6.933
Tocopheryl nicotinate 2.000
Permethyl101A 1 3．000
Sepigel 2 2．500
Q2-1403 3 2．000
Isostearic acid isopropyl ester 1.330
Arlatone2121 4 1．000
Hexadecanol CO-1695 0.720
The cotton acid esters of SEFA 50.670
Tocopherol acetate ester 0.500
Pantothenylol 0.500
Adol62 6 0．480
Kobo titanium dioxide 0.400
Sodium hydroxide 50% 0.0125
Water
Fiery5 7 0．150
EDTA disodium 0.100
Glydant?Plus 8 0．100
Myrj59 9 0．100
Emersol132 10 0．100
Pigment 0.00165
Purified water adds to 100 in right amount
Embodiment 3
Be the embodiment that belongs to the skin ointment frost of the present composition below.Compositions forms every hurdle composition by using routine techniques in conjunction with also mixing, the amount with about 0.5 gram～about 50 grams is applied to skin then.
Composition % weight
Glycerol 6.933
Nicotiamide 2.000
Permethyl101A 1 4．000
Q2-1403 3 2．000
Isostearic acid isopropyl ester 1.330
Arlatone2121 4 1．000
Hexadecanol CO-1695 0.720
The cotton acid esters of SEFA 50.670
Carbopol954 11 0．500
Tocopherol acetate ester 0.500
Pantothenylol 0.500
Adol62 6 0．480
Kobo titanium dioxide 0.400
Sodium hydroxide 50% 0.250
Water
Fiery5 7 0．150
EDTA disodium 0.100
Glydant?Plus 8 0．100
Myri59 9 0．100
Emersol132 10 0．100
Carbopol1382 12 0．100
Pigment 0.00165
Purified water adds to 100 in right amount
1. 2-Methylpentadecane, Presperse Inc., South Plainfield, NJ
Polyacrylamide (with) C 13-14Isoparaffin (with) Laureth-7, SeppicCorporation, Fairfield, NJ
Polydimethylsiloxane (with) dimethiconol, Dow Corning Corp., Midland, MI
4. sorbitan monostearate and coconut oil sucrose ester, ICI Americas, Inc., Wilmington, DE
5. fatty acid cane sugar ester, Procter and Gamble, Cincinnati, OH
6. octadecanol, Procter and Gamble, Cincinnati, OH
7．Fiery5n／a，Procter?and?Gamble，Cincinnati，OH
8.DMDM hydantoin (with) butyl carbamic acid sulphur is for propynyl ester, Lonza Inc., Fairlawn, NJ
9.PEG-100 stearate, ICI Americas Inc., Wilmington, DE
10. stearic acid, Henkel Corp., Kankakee, IL
11. acrylate copolymer, BF Goodrich, Cleveland OH
12. acrylate copolymer, BF Goodrich, Cleveland OH

Claims (10)

1. by the skin care compositions to the safe and effective amount of dermal administration water is adsorbed onto on the mammal skin or absorbs the method for mammal, described compositions contains:
A. be selected from vitamin B 3Absorption of the water of chemical compound and composition thereof or water absorption enhancer and
B. be used for described vitamin B 3The dermatological acceptable carrier of chemical compound.
2. according to the process of claim 1 wherein water absorption or to absorb be that concentration level by raising is selected from the skin protein of nature moisturizing factor precursor, keratin, involurin and composition thereof produces.
3. according to each method in the aforementioned claim, wherein the concentration of absorption or absorption enhancer is greater than 5%.
4. according to each method in the aforementioned claim, wherein said vitamin B 3Chemical compound is selected from the non-vasodilation ester of nicotiamide, nicotinamide derivates, nicotinic acid, and composition thereof.
5. according to each method in the aforementioned claim, wherein compositions further contains the additional skin activity composition that is selected from hydroxy acid, exfoliation agent, sunscreen, antioxidant, retinoid and composition thereof.
6. according to each method in the aforementioned claim, wherein hydroxy acid is a salicylic acid; The exfoliation agent is selected from zwitterionic surfactant and composition thereof; The daylight blocker is selected from zinc oxide, titanium dioxide and composition thereof; Sunscreen is selected from 2-ethylhexyl-right-Methoxycinnamate, 4,4 '-tert-butyl group methoxy dibenzoyl base-methane, Phenylbenzimidazolesulfonic acid, octocrylene and composition thereof; Antioxidant is selected from tocopherol, its esters and composition thereof; Retinoid is selected from retinol, retinyl acetate, Vitamin A propionate and composition thereof.
7. the method for mammal skin humidification or hydration, this method comprises the skin care compositions of using safe and effective amount, described compositions contains:
A. at least a vitamin B of safe and effective amount 3Chemical compound; With
B. the acceptable carrier of making up;
So that keep vitamin B on the skin 30.001 milligram/centimetre of chemical compound 2～1 milligram/centimetre 2Least concentration.
8. according to each method in the aforementioned claim, wherein vitamin B 3The minimum skin concentration of chemical compound reaches by using dermal compositions repeatedly.
9. according to each method in the aforementioned claim, wherein skin care compositions further contains film former or direct reinforcing agent.
10. comprise skin care compositions and about the goods of information and/or explanation, this skin care compositions contains 0.1%～40% vitamin B in the packing that is used for it 3Chemical compound.
CN998036811A 1998-03-16 1999-03-12 Skin moisturizing compositions Pending CN1292680A (en)

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US7813698P 1998-03-16 1998-03-16
US60/078,136 1998-03-16

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KR (1) KR20010041868A (en)
CN (1) CN1292680A (en)
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BR (1) BR9907944A (en)
CA (1) CA2323101A1 (en)
WO (1) WO1999047117A1 (en)

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Publication number Priority date Publication date Assignee Title
KR100581374B1 (en) * 1999-04-22 2006-05-24 주식회사 엘지생활건강 Composition of cosmetics comprising effect of improving subdued skin color
JP4540872B2 (en) * 2001-04-02 2010-09-08 株式会社資生堂 Inhibitor or repair agent for skin damage caused by drying
KR20020088004A (en) * 2001-05-07 2002-11-25 박종문 An toilet composition for protecting and combating blemishes and aging of the skin
WO2002092070A1 (en) * 2001-05-11 2002-11-21 Elan Corporation, Plc Isostearic acid salts as permeation enhancers
JP4680571B2 (en) * 2003-12-25 2011-05-11 カルピス株式会社 Moisturizer for ingestion
JP2006241095A (en) * 2005-03-04 2006-09-14 National Univ Corp Shizuoka Univ Filaggrin synthesis-promoting agent and ultraviolet ray injury emollient
EP2742942B1 (en) 2012-12-14 2019-05-22 Unilever N.V. Niacinamide for inducing generation of antimicrobial peptides
EP3071188A4 (en) * 2013-11-18 2017-08-23 Polyremedy, Inc. Micelle-based delivery of dermal therapeutic materials
KR101909594B1 (en) * 2016-08-18 2018-10-18 (주)진셀팜 Cosmetic compositon for removing heavy metal or fine dust containing extracts of rhapis excelsa and ficus robusta

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH062659B2 (en) * 1985-11-22 1994-01-12 鐘紡株式会社 Skin cosmetics
JPS62126106A (en) * 1985-11-26 1987-06-08 Kanebo Ltd Skin cosmetic
JPS62138410A (en) * 1985-12-10 1987-06-22 Kanebo Ltd Skin cosmetic
AU3115097A (en) * 1996-04-23 1997-11-12 Procter & Gamble Company, The Methods of regulating skin condition with centella asiatica extract

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AU3000699A (en) 1999-10-11
JP2002506805A (en) 2002-03-05
WO1999047117A1 (en) 1999-09-23
EP1063965A1 (en) 2001-01-03
KR20010041868A (en) 2001-05-25
CA2323101A1 (en) 1999-09-23

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