KR20000064969A - 돌연변이에의한질병을치료하는방법과조성물 - Google Patents

돌연변이에의한질병을치료하는방법과조성물 Download PDF

Info

Publication number
KR20000064969A
KR20000064969A KR1019980708445A KR19980708445A KR20000064969A KR 20000064969 A KR20000064969 A KR 20000064969A KR 1019980708445 A KR1019980708445 A KR 1019980708445A KR 19980708445 A KR19980708445 A KR 19980708445A KR 20000064969 A KR20000064969 A KR 20000064969A
Authority
KR
South Korea
Prior art keywords
sequence
nucleic acid
seq
dna
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019980708445A
Other languages
English (en)
Korean (ko)
Inventor
에릭 비. 키멕
엘리슨 콜-스트러스
경진 윤
Original Assignee
아브람 엠. 골드핑거
토마스 제퍼슨 대학교
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아브람 엠. 골드핑거, 토마스 제퍼슨 대학교 filed Critical 아브람 엠. 골드핑거
Publication of KR20000064969A publication Critical patent/KR20000064969A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019980708445A 1996-05-01 1997-05-01 돌연변이에의한질병을치료하는방법과조성물 Ceased KR20000064969A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8/640,517 1996-05-01
US08/640,517 US5760012A (en) 1996-05-01 1996-05-01 Methods and compounds for curing diseases caused by mutations
PCT/US1997/007362 WO1997041141A1 (en) 1996-05-01 1997-05-01 Methods and compounds for curing diseases caused by mutations

Publications (1)

Publication Number Publication Date
KR20000064969A true KR20000064969A (ko) 2000-11-06

Family

ID=24568577

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980708445A Ceased KR20000064969A (ko) 1996-05-01 1997-05-01 돌연변이에의한질병을치료하는방법과조성물

Country Status (9)

Country Link
US (1) US5760012A (Direct)
EP (1) EP0906328A4 (Direct)
JP (1) JP2000509282A (Direct)
KR (1) KR20000064969A (Direct)
CN (1) CN1207302C (Direct)
AU (1) AU708658B2 (Direct)
CA (1) CA2252762A1 (Direct)
NZ (1) NZ332297A (Direct)
WO (1) WO1997041141A1 (Direct)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888983A (en) * 1996-05-01 1999-03-30 Thomas Jefferson University Method and oligonucleobase compounds for curing diseases caused by mutations
US5731181A (en) * 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
EP1007712A4 (en) * 1997-08-05 2004-06-30 Kimeragen Inc USE OF DUPLEX OLIGONUCLEOTIDES TO AFFECT LOCAL GENETIC CHANGES IN PLANTS
US6004804A (en) * 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6010907A (en) 1998-05-12 2000-01-04 Kimeragen, Inc. Eukaryotic use of non-chimeric mutational vectors
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
WO2000042561A2 (en) 1999-01-19 2000-07-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
WO2000061184A2 (en) * 1999-04-08 2000-10-19 Glenn Gregory M Dry formulation for transcutaneous immunization
WO2000071165A2 (en) * 1999-05-21 2000-11-30 The University Of Miami Use of chimeric mutational vectors to change endogenous sequences in solid tissues
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
EP1196559B1 (en) * 1999-07-02 2006-07-05 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6271360B1 (en) 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US7430477B2 (en) * 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6656700B2 (en) * 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6686188B2 (en) 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US20030017593A1 (en) * 2000-06-05 2003-01-23 Gamper Howard B. Binary hybrid mutational vectors
US6875907B2 (en) 2000-09-13 2005-04-05 Pioneer Hi-Bred International, Inc. Antimicrobial peptides and methods of use
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
AU2002303176A1 (en) * 2001-03-27 2002-10-15 University Of Delaware Genomics applications for modified oligonucleotides
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
US20040078837A1 (en) * 2001-08-02 2004-04-22 Shannon Mark E. Four human zinc-finger-containing proteins: MDZ3, MDZ4, MDZ7 and MDZ12
US20030084473A1 (en) * 2001-08-09 2003-05-01 Valigen Non-transgenic herbicide resistant plants
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
AU2003220119A1 (en) * 2002-03-07 2003-09-22 University Of Delaware Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
BRPI0313202A8 (pt) * 2002-08-05 2016-08-16 Atugen Ag Formas adicionais para interferir com as moléculas de rna
AU2003282477A1 (en) * 2002-10-07 2004-05-04 Napro Bio Therapeutics, Inc. Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
WO2004050907A2 (en) * 2002-12-03 2004-06-17 Aarhus Universitet Method for determing predisposition to manifestation of immune system related diseases
WO2004098508A2 (en) * 2003-04-30 2004-11-18 Napro Biotherapeutics, Inc. Methods for production of non-disease causing hemoglobin by ex vivo oligonucleotide gene editing of human stem/progenitor cells
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
AU2004326206B2 (en) 2004-12-28 2011-03-17 Pioneer Hi-Bred International, Inc. Improved grain quality through altered expression of seed proteins
WO2006091194A1 (en) 2005-02-23 2006-08-31 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes
WO2006119775A2 (en) 2005-05-11 2006-11-16 Aarhus Universitet Method for diagnosis and treatment, of a mental disease
EP2261362A3 (en) 2005-05-25 2011-04-20 Pioneer Hi-Bred International Inc. Methods for improving crop plant architecture and yield
CN1880458B (zh) * 2005-06-15 2010-04-28 中国医学科学院基础医学研究所 人β-珠蛋白基因簇的人源染色体打靶载体及其应用
US20070107084A1 (en) 2005-11-10 2007-05-10 Pioneer Hi-Bred International, Inc. Dof (DNA binding with one finger) sequences and methods of use
US20070199096A1 (en) 2005-11-14 2007-08-23 E.I. Du Pont De Nemours And Company Compositions and Methods for Altering Alpha- and Beta-Tocotrienol Content
US7592505B2 (en) 2005-12-30 2009-09-22 Pioneer Hi-Bred International, Inc. UDP-xylose synthases (UXS) polynucleotides, polypeptides, and uses thereof
NZ597682A (en) * 2006-01-12 2014-02-28 Incima Ipco B V Epsps mutants
AU2007212168A1 (en) 2006-02-09 2007-08-16 Pioneer Hi-Bred International, Inc. Genes for enhancing nitrogen utilization efficiency in crop plants
CA2649734A1 (en) 2006-04-19 2007-11-01 Pioneer Hi-Bred International, Inc. Isolated polynucleotide molecules corresponding to mutant and wild-type alleles of the maize d9 gene and methods of use
UA107442C2 (uk) 2006-06-28 2015-01-12 Nucelis Inc Суміш жирних кислот та її застосування
WO2009085033A1 (en) * 2007-12-27 2009-07-09 Cibus Llc Alkylester fatty acid blends and uses therefor
UA125846C2 (uk) 2007-04-04 2022-06-22 Басф Плант Саєнс Гмбх Мутант ahas
EP2152733A2 (en) 2007-05-25 2010-02-17 CropDesign N.V. Yield enhancement in plants by modulation of maize alfins
EA036997B1 (ru) 2007-10-05 2021-01-25 СИБАС ЕУРОП Би.Ви. Растение и семя ярового масличного рапса brassica napus, содержащие мутированные гены синтазы ацетогидроксикислот
WO2009064771A2 (en) 2007-11-12 2009-05-22 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes
AR069392A1 (es) 2007-11-20 2010-01-20 Pioneer Hi Bred Int Genes de senalizacion de etileno en maiz y su modulacion para aumentar la tolerancia al estres en plantas
AU2009248852B9 (en) * 2008-05-23 2015-08-13 Cibus Europe B.V. Production of squalene using yeast
AP2011005671A0 (en) 2008-09-26 2011-04-30 Basf Agrochemical Products Bv Herbicide-resistant AHAS-mutants and methods of use.
BRPI0920107A2 (pt) 2008-10-30 2015-08-18 Pioneer Hi Bred Int Polinucleotídeo isolado, cassete de expressão recombinante, célula hospedeira, planta tansgênica, semente transgênica, método para modular gs em uma planta, método para reduzir atividade de polipeptídeo da enzima gs em uma célula de planta.
US8431775B2 (en) 2008-12-04 2013-04-30 Pioneer Hi Bred International Inc Methods and compositions for enhanced yield by targeted expression of knotted1
EP2387567B1 (en) 2009-01-14 2014-06-11 The Salk Institute for Biological Studies Compounds that protect against amyloid diseases
WO2010101818A1 (en) 2009-03-02 2010-09-10 Pioneer Hi-Bred International, Inc. Nac transcriptional activators involved in abiotic stress tolerance
UA108071C2 (uk) 2009-04-14 2015-03-25 Піонер Хай-Бред Інтернешнл, Інк. Спосіб поліпшення витривалості до нестачі азоту у рослини
MX2011011678A (es) 2009-05-04 2011-12-06 Pioneer Hi Bred Int Mejora de la produccion en plantas mediante la modulacion del factor de transcripcion ap2.
MX2012001080A (es) 2009-07-24 2012-03-26 Pionner Hi Bred International Inc Uso de agrupaciones de componentes del dominio de dimerizacion para modular la arquitectura de las plantas.
US20110035843A1 (en) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants
MX2012003972A (es) 2009-10-02 2012-05-08 Pionner Hi Bred International Inc Regulacion a la baja de acc sintasa para mejorar el rendimiento de las plantas.
HUE034245T2 (en) 2009-11-23 2018-02-28 Nucelis Llc Methods and preparations for the preparation of squalene using yeast
CA2786001A1 (en) 2009-12-31 2011-07-07 Pioneer Hi-Bred International, Inc. Engineering plant resistance to diseases caused by pathogens
WO2011085062A1 (en) 2010-01-06 2011-07-14 Pioneer Hi-Bred International, Inc. Identification of diurnal rhythms in photosynthetic and non-photosynthetic tissues from zea mays and use in improving crop plants
CA2788198C (en) 2010-01-26 2021-01-19 Pioneer Hi-Bred International, Inc. Hppd-inhibitor herbicide tolerance
WO2011139431A1 (en) 2010-05-06 2011-11-10 Pioneer Hi-Bred International, Inc. Maize acc synthase 3 gene and protein and uses thereof
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
CA2805941A1 (en) 2010-08-13 2012-02-16 Pioneer Hi-Bred International, Inc. Methods and compositions for targeting sequences of interest to the chloroplast
EP2426204A1 (en) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontaneous nodule organogenesis in plants
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
CA2833876A1 (en) 2011-04-29 2012-11-01 Pioneer Hi-Bred International, Inc. Down-regulation of a homeodomain-leucine zipper i-class homeobox gene for improved plant performance
EP2721160A2 (en) 2011-06-14 2014-04-23 Synthon Biopharmaceuticals B.V. Compositions and methods for making and biocontaining auxotrophic transgenic plants
AR087167A1 (es) 2011-07-12 2014-02-26 Two Blades Foundation Genes de resistencia al tizon tardio
CA2853775A1 (en) 2011-10-31 2013-05-10 Pioneer Hi-Bred International, Inc. Improving plant drought tolerance, nitrogen use efficiency and yield
WO2013138309A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
EA201491670A1 (ru) 2012-03-13 2015-07-30 Пайонир Хай-Бред Интернэшнл, Инк. Генетическое снижение мужской репродуктивной функции у растений
US10045499B2 (en) 2012-05-24 2018-08-14 Iowa State University Research Foundation, Inc. Arabidopsis nonhost resistance gene(s) and use thereof to engineer disease resistant plants
WO2014011901A2 (en) * 2012-07-11 2014-01-16 Sangamo Biosciences, Inc. Methods and compositions for delivery of biologics
EP2885411B1 (en) 2012-08-16 2018-12-05 VIB vzw Means and methods for altering the lignin pathway in plants
EP2935593A2 (en) 2012-12-21 2015-10-28 Pioneer Hi-Bred International, Inc. Compositions and methods for auxin-analog conjugation
US20160002648A1 (en) 2013-03-11 2016-01-07 Mei Guo Genes for improving nutrient uptake and abiotic stress tolerance in plants
US9803214B2 (en) 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
US20160010101A1 (en) 2013-03-13 2016-01-14 Pioneer Hi-Bred International, Inc. Enhanced nitrate uptake and nitrate translocation by over- expressing maize functional low-affinity nitrate transporters in transgenic maize
US20160017360A1 (en) 2013-03-13 2016-01-21 Pioneer Hi-Bred International, Inc. Functional expression of bacterial major facilitator superfamily mfs gene in maize to improve agronomic traits and grain yield
PE20151922A1 (es) 2013-03-14 2016-01-16 Cibus Us Llc Genes de aleno oxido sintasa 2 (aos2) mutados
US20140304857A1 (en) 2013-03-14 2014-10-09 Pioneer Hi Bred International Inc Maize stress related transcription factor 18 and uses thereof
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
AU2014233519B2 (en) 2013-03-15 2020-05-14 Cibus Europe B.V. Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene
WO2014143996A2 (en) 2013-03-15 2014-09-18 Pioneer Hi-Bred International, Inc. Compositions and methods of use of acc oxidase polynucleotides and polypeptides
WO2014152507A2 (en) 2013-03-15 2014-09-25 Pioneer Hi-Bred International, Inc. Modulation of acc deaminase expression
HK1220864A1 (zh) 2013-03-15 2017-05-19 希博斯美国有限公司 采用寡核苷酸介导的基因修复提高靶向基因修饰的效率的方法和组合物
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
CA2904817C (en) 2013-03-21 2022-10-18 Vib Vzw Means and methods for the reduction of photorespiration in crops
BR112015032956B1 (pt) 2013-07-09 2022-09-13 Board Of Trustees Of Michigan State University Método para produzir uma planta transgênica e cassete de expressão
US11459579B2 (en) 2013-07-09 2022-10-04 Board Of Trustees Of Michigan State University Transgenic plants produced with a K-domain, and methods and expression cassettes related thereto
US20170166920A1 (en) 2014-01-30 2017-06-15 Two Blades Foundation Plants with enhanced resistance to phytophthora
HRP20240186T1 (hr) 2014-03-14 2024-05-10 Cibus Us Llc Postupci i kompozicije za povećanje efikasnosti ciljane modifikacije gena korištenjem reparacije gena posredovane oligonukleotidima
WO2015171603A1 (en) 2014-05-06 2015-11-12 Two Blades Foundation Methods for producing plants with enhanced resistance to oomycete pathogens
CA2954201A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
WO2016057515A2 (en) 2014-10-06 2016-04-14 Altria Client Services Llc Genetic control of axillary bud growth in tobacco plants
US20170369902A1 (en) 2014-12-16 2017-12-28 Pioneer Hi-Bred International, Inc. Restoration of male fertility in wheat
EP3294892B1 (en) 2015-05-09 2020-11-25 Two Blades Foundation Late blight resistance gene from solanum americanum and methods of use
WO2017062790A1 (en) 2015-10-09 2017-04-13 Two Blades Foundation Cold shock protein receptors and methods of use
CA3014036A1 (en) 2016-02-09 2017-08-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
CN117089526A (zh) 2016-03-11 2023-11-21 奥驰亚客户服务有限公司 用于生产烟杈减少或消除的烟草植物和制品的组合物和方法
JP7066126B2 (ja) 2016-08-09 2022-05-13 ブイアイビー ブイゼットダブリュ セルロースシンターゼ阻害剤および突然変異体植物
EP3523439A1 (en) 2016-10-07 2019-08-14 Altria Client Services LLC Composition and methods for producing tobacco plants and products having reduced tobacco-specific nitrosamines (tsnas)
EP3555299A1 (en) 2016-12-16 2019-10-23 Two Blades Foundation Late blight resistance genes and methods of use
WO2018140214A1 (en) 2017-01-24 2018-08-02 Pioneer Hi-Bred International, Inc. Nematicidal protein from pseudomonas
US11261458B2 (en) 2017-07-28 2022-03-01 Two Blades Foundation Potyvirus resistance genes and methods of use
US11104912B2 (en) 2017-09-11 2021-08-31 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers
WO2019108619A1 (en) 2017-11-28 2019-06-06 Two Blades Foundation Methods and compositions for enhancing the disease resistance of plants
US11034969B2 (en) 2017-12-22 2021-06-15 Altria Client Services Llc Plant comprising recombinant polynucleotides encoding a pigment regulatory transcription factor with a tissue-preferred promoter
CN118830491A (zh) 2018-01-09 2024-10-25 希博斯美国有限公司 防碎基因和突变
WO2019140351A1 (en) 2018-01-12 2019-07-18 Two Blades Foundation Stem rust resistance genes and methods of use
US11377665B2 (en) 2018-04-03 2022-07-05 Altria Client Services Llc Composition and methods for producing tobacco plants and products having increased phenylalanine and reduced tobacco-specific nitrosamines (TSNAs)
UA129286C2 (uk) 2018-04-04 2025-03-12 Сайбас Юес Ллс Гени fad2 і мутації
GB201815670D0 (en) * 2018-09-26 2018-11-07 Univ Oxford Innovation Ltd Protein editing
EP3914069A1 (en) 2019-01-24 2021-12-01 Altria Client Services LLC Tobacco plants comprising reduced nicotine and reduced tobacco specific nitrosamines
CN112111528B (zh) * 2019-06-21 2024-04-02 华东师范大学 一种内含子异常剪接的修复方法
US20220251595A1 (en) 2019-06-27 2022-08-11 Two Blades Foundation Engineered atrlp23 pattern recognition receptors and methods of use
US20210071193A1 (en) 2019-07-12 2021-03-11 The Regents Of The University Of California Plants with enhanced resistance to bacterial pathogens
CN117917951A (zh) 2021-05-11 2024-04-23 双刃基金会 用于抗病性功能测试的植物抗病基因文库的制备方法
WO2023012342A1 (en) 2021-08-06 2023-02-09 Kws Vegetables B.V. Durable downy mildew resistance in spinach
US20250002929A1 (en) 2021-09-30 2025-01-02 The Sainsbury Laboratory Plant disease resistance genes against stem rust and methods of use
EP4460571A1 (en) 2022-01-05 2024-11-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2025019221A1 (en) 2023-07-15 2025-01-23 Two Blades Foundation Broad-spectrum polerovirus resistance gene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3585238B2 (ja) * 1993-12-09 2004-11-04 トーマス ジェファーソン ユニバーシティー 真核細胞における部位特異的突然変異誘発のための化合物および方法

Also Published As

Publication number Publication date
CN1207302C (zh) 2005-06-22
CN1223660A (zh) 1999-07-21
CA2252762A1 (en) 1997-11-06
EP0906328A1 (en) 1999-04-07
JP2000509282A (ja) 2000-07-25
US5760012A (en) 1998-06-02
NZ332297A (en) 2000-03-27
AU2822597A (en) 1997-11-19
AU708658B2 (en) 1999-08-12
EP0906328A4 (en) 2003-06-18
WO1997041141A1 (en) 1997-11-06

Similar Documents

Publication Publication Date Title
KR20000064969A (ko) 돌연변이에의한질병을치료하는방법과조성물
US5888983A (en) Method and oligonucleobase compounds for curing diseases caused by mutations
KR20000011075A (ko) 비-자연적인 뉴클레오티드를 가지는 키메라 돌연변이 벡터
US7258854B2 (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7226785B2 (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
IL323623A (en) Systems and methods for treating hemoglobin diseases
CN110337493B (zh) 用于治疗肌强直性营养不良的组合物和方法
WO2021119040A1 (en) Modified cells and methods for the treatment of hemoglobinopathies
CA3093701A1 (en) Systems and methods for the treatment of hemoglobinopathies
TW202111122A (zh) 藉靶向dmpk基因治療肌肉萎縮症之方法
US20220025363A1 (en) Systems and methods for the treatment of hemoglobinopathies
AU2001249488C8 (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
WO2025049807A1 (en) Methods and compositions for engineered da neuronal cells
WO2024254566A2 (en) Systems and methods for the treatment of hemoglobinopathies
WO1996022688A1 (en) A proliferation-inhibiting gene sequence and its use in the treatment of cancer and other diseases
AU2001249488A1 (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
ZA200207742B (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides.

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 19981022

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20020429

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20040525

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20041201

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20040525

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I