KR20000024835A - Nutrient composition containing chitosan oligosaccharide for feed - Google Patents

Abstract

PURPOSE: A nutrient composition for feed is provided, which contains chitosan oligosaccharide to improve the growth rate and the disease-resistance of domestic animals and has no side effect. CONSTITUTION: A nutrient composition for feed comprises 500-5,000 mg/kg of chitosan oligosaccharide; vitamins such as vitamin A, D3, E, B1, B2, B6, B12, C and K3, nicotinic acid amide, folic acid, calcium pantothenate and choline chloride; and optionally amino acid and minerals. Preferably the nutrient composition is administered in the amount of 2-4 kg per 1 ton of feed.

Description

Chitosan Oligosaccharide-containing Feed Additives

The present invention relates to a nutrient composition added to animal feed for the purpose of promoting the growth of animals, improving feed efficiency and enhancing the anti-medical force against various diseases, and in particular, a nutrient composition for feed addition comprising chitosan oligosaccharides and vitamins necessary for animals. It is about.

Animal feed, such as chicken, pig, and cow, is generally added with feed additives for the purpose of promoting livestock growth and improving feed efficiency. Conventional feed additives include vitamins and dry cells. Probiotics have been used primarily.

Vitamin products vary in composition, but are usually vitamins A, B ₂ , B ₆ , B ₁₂ , calcium pantothenate, niacin, vitamin C, vitamin D, vitamin E, vitamin K, etc. It contains minerals such as copper, iron, cobalt, and iodine, and it is added and administered to animal feeds for the purpose of promoting animal growth, improving feed efficiency, increasing anti-potent, preventing abnormal milk and preventing disease treatment. .

Probiotics typically include Saccharomyces cervisiae, Aspergillus oryzae, Bacillus thuringiensis, Lactobacillus acidophilus, and Rhodobacter capsularus. (Rhodobacter capsulatus), Lactobacillus sp., Streptomyces sp., Bacillus sp., Etc., contain the strains as dry cells. It is used for the purpose of increasing feed efficiency, reducing stress and early recovery, adjuvant treatment of various diseases, improving utilization of various nutrients and improving palatability by improving intestinal function.

Previously, vitamins were mainly used as nutritional supplements for feed, but recently, the use of probiotics has increased, and vitamins and probiotics are similar in terms of overall amount of use, and their purpose and effects are also evaluated.

An object of the present invention is to provide a new nutritional supplement composition for safe addition without side effects and showing more excellent effects in terms of promoting the growth of the livestock, improving the weight gain, improved feed efficiency and the like compared to the conventional feed additives.

The present invention adds chitosan oligosaccharides to general vitamins used as nutritional supplements for feed, and the beneficial effects of vitamins and the antimicrobial, immunopotentiating and anti-potentiating effects of chitosan oligosaccharides act synergistically to promote animal growth and feed. It is characterized by exhibiting excellent effects such as efficiency improvement, weight gain rate improvement, immunity enhancement, and anti-medical history.

Vitamins are essential for the normal metabolism of all cells in animals, and most vitamins are required in very small amounts in the body. However, not all vitamins needed for animal growth need to be supplied as feed because some vitamins are synthesized and supplied in the animal's body. For example, ruminants can supply the amount required for metabolism in the body because microorganisms living in the rumen synthesize vitamin B group, and in addition, vitamin C can be synthesized and supplied by many animals in the body. It is known that there is no need to supply. Therefore, the vitamins developed as feed supplements are usually formulated around vitamins necessary for the administration animal, and aim to include sufficient amounts that do not interfere with growth while preventing deficiency.

Therefore, the composition of the present invention mainly aims to be used in chickens, pigs, cows, etc., and thus contains sufficient amounts of vitamins necessary for the growth of these animals, and the composition and content of the specific vitamins included in the composition According to the administration animal and administration conditions, it is suitably adjusted within the administration range of a general vitamin agent. In addition to the vitamin, the composition may further include nutrients such as amino acids and minerals.

Chitosan oligosaccharide, which is the main component of the present composition, is a partially decomposed product of chitin and chitosan, and is a high functional bioactive substance that exhibits high water solubility while maintaining the physiological properties of chitosan as it is. Chitin and chitosan are naturally occurring polysaccharides and are recently attracting special attention. Chitin (β-poly-Ν-acetyl-D-glucosamine) is a shell of crustaceans such as crabs. It is a kind of nitrogen-containing polysaccharide extracted from the nature, but is widely used in nature, but its use is very limited because it is insoluble in water-soluble solvents. In comparison, chitosan is a natural polymer made by deacetylating chitin (β-poly-D-glucosamine), that is, a natural polymer polysaccharide in which glucosamine is bound to β-1,4, and the chitin is heated in sodium hydroxide. It is obtained by the deacetylation treatment of, and has been widely used because it has a wide range of physiological activities and exhibits water solubility in weak acidity. However, even though it shows water solubility in weak acidity, chitosan is generally hardly soluble and highly viscous, so it is difficult to apply to food because it changes the physical properties of food, and it is not easily absorbed by the human digestive tract even when ingested due to its low solubility in water and digestive fluids. It is difficult to expect the effect compared to the excellent functionality.

Chitosan Oligo Saccharide solves these problems of chitin and chitosan, and it shows high solubility in water-soluble solvents while maintaining the physiological properties of chitosan, so it is easy to add to food and has excellent body absorption rate. It is attracting the attention of the food and pharmaceutical industry as a functional bioactive substance. Chitosan oligosaccharides have the structure of chitosan, and two to ten glucosamine hexasaccharides (monosaccharides) are bound and have the following chemical structure.

(an integer from 0 to 8)

Since chitosan oligosaccharides maintain the physiological properties of chitosan, they enhance immune function, act on cellular activity, lower blood pressure, regulate cholesterol, promote excretion of carcinogens, release radioactive substances, and improve anemia and hepatic function. It has been reported to exhibit a variety of physiological activities, such as intestinal and digestive action, uric acid release promoting action, antibacterial action, anti-cancer and anti-tumor action, calcium absorption promotion action, blood sugar rise suppression effect.

The content of chitosan oligosaccharides contained in the composition can be adjusted according to the nutritional state, health condition, feed of the administered animal, etc., but usually 0.5 to 5g per kg composition is preferred.

The composition according to the present invention shows an excellent synergistic effect of the chitosan oligosaccharides and vitamins, which has not been found in the conventional feed additives, an effect of increasing the growth rate, enhancing the immunity, enhancing the anti-potentiation effect, and improving the feed efficiency. .

This composition is made according to the preparation of general powders based on chitosan oligosaccharides and vitamins. The specific composition of the vitamin can be adjusted according to the administration animal and administration conditions, and excipients commonly used in the pharmaceutical, such as lactose, glucose can be used as an excipient.

In addition, the composition may further include other nutritional ingredients that are acceptable for animals.

The composition is mixed and administered to animal feeds such as chicken, pig, cow, etc., the dosage can be adjusted according to the nutritional state, health condition, feed of the administered animal, and usually administered about 2 to 4kg per tonne of feed It is desirable to.

The present invention will be described in more detail with reference to the following Examples. However, the scope of the present invention is not limited by the following examples, and ordinary changes by those skilled in the art are possible within the scope of the technical idea of the present invention.

Example 1

Preparation of Feed Additives Containing Chitosan Oligosaccharides

According to the manufacturing method of the pharmacovigilant VI amendment powder was made a nutritional composition for feed addition according to the present invention in the composition shown in Table 1.

Table 1

Ingredients Content in 1 kg Vitamin A 1,250,000 I.U. Vitamin D ₃ 250,000 I.U. Vitamin E 500mg Vitamin B ₁ HCl 500mg Vitamin B ₂ 500mg Vitamin B ₆ HCl 100mg Vitamin B ₁₂ 500 µg Vitamin c 1,000mg Vitamin K ₃ 200mg Nicotinic acid amide 1,000mg Folic acid 50 mg Calcium Pantothenate 500mg Choline chloride 10,000mg DL-Methionine 2,000 mg Lysine chloride 200mg Chitosan oligosaccharides 2,000 mg Excipients (lactose) Quantity

Comparative Example 1

Commercial probiotics containing 1.5 × 10 ¹¹ cfu or more of Saccharomyces cerevisiae per kg were prepared for comparative experiments.

Example 2

Measurement of weight change after administration

Exam conditions

Sample 1: Composition of the Invention Prepared According to Example 1

Sample 2: Probiotic of Comparative Example 1

Control: Feed only

Experimental animal: Weaning pig (average age 24 days)

Number of experiments: 70

Weaning piglets were divided into two groups of 35 heads of 35 heads (groups A and B). For each group, 15 heads had the composition of Example 1, 15 heads had the probiotic of Comparative Example 1, and the remaining 5 heads had only feed for 70 days After administration, weight gain and feed efficiency were measured and compared. The experimental results of group A are shown in Table 2, and the experimental results of group B are shown in Table 3.

TABLE 2

sample Two can Starting average weight (㎏) End Average Weight (㎏) Weight gain (kg) Feed efficiency One 15 5.9 29.72 23.82 1.613 2 15 5.1 26.62 21.52 1.783 Control 5 5.12 26.68 21.56 1.782

TABLE 3

sample Two can Starting average weight (㎏) End Average Weight (㎏) Weight gain (kg) Feed efficiency One 15 6.7 31.4 24.7 1.590 2 15 6.5 29.13 22.63 1.740 Control 5 6.3 27.9 21.6 1.774

As a result, the probiotics of Comparative Example 1 showed almost no substantial effect in terms of weight gain and feed efficiency, whereas the composition of the present invention showed a significant improvement.

Example 3

Safety test

Exam conditions

Sample: Composition of the invention prepared according to Example 1

Experimental animal: Weaning pig (average age 24 days)

Number of experiments: 15

Dosage: 10 kg per ton of feed

Duration of administration: Up to 75 days after birth

Clinical observation period: 55 days

Weaning piglets showing abnormalities in clinical symptoms were not found after 15 heads of weaning pigs were administered 5 times the usual dose up to 75 days of age. Therefore, the clinical symptoms showed that the safety of the composition in pigs was recognized.

As can be seen from the above embodiment, the composition according to the present invention, unlike the conventional dietary supplement for nutrients shows a significant significant improvement in terms of weight gain and feed efficiency, it is useful to replace the conventional feed additives Can be used.

Claims (3)

A chitosan oligosaccharide containing 500 to 5,000 mg / kg and vitamins necessary for the animal as a main ingredient, the nutritional composition for feed addition characterized in that the mixed administration of 2 to 4 kg per ton of animal feed. The method of claim 1, wherein the vitamin is vitamin A, vitamin D ₃ , vitamin E, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin K ₃ , nicotinamide, folic acid, calcium pantothenate and A composition comprising choline chloride. The composition of claim 1 or 2, wherein the composition further comprises vitamins, amino acids and minerals necessary for the animal.