KR19990036081A - 인간 엠피52 에이알지 단백질 - Google Patents

인간 엠피52 에이알지 단백질 Download PDF

Info

Publication number
KR19990036081A
KR19990036081A KR1019980700747A KR19980700747A KR19990036081A KR 19990036081 A KR19990036081 A KR 19990036081A KR 1019980700747 A KR1019980700747 A KR 1019980700747A KR 19980700747 A KR19980700747 A KR 19980700747A KR 19990036081 A KR19990036081 A KR 19990036081A
Authority
KR
South Korea
Prior art keywords
arg
tibial
human
protein
pharmaceutical composition
Prior art date
Application number
KR1019980700747A
Other languages
English (en)
Korean (ko)
Inventor
미치오 기무라
토모아키 마츠모토
신지 카와이
유키오 후지노
미키코 타카하시
Original Assignee
미카엘 파울리스타
바이오팜 게젤샤프트 쭈어 바이오테히놀로지셴 엔트비클룽 폰 파르마카 엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미카엘 파울리스타, 바이오팜 게젤샤프트 쭈어 바이오테히놀로지셴 엔트비클룽 폰 파르마카 엠베하 filed Critical 미카엘 파울리스타
Publication of KR19990036081A publication Critical patent/KR19990036081A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1019980700747A 1995-08-03 1996-08-02 인간 엠피52 에이알지 단백질 KR19990036081A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95112241 1995-08-03
EP951122441.5 1995-08-03

Publications (1)

Publication Number Publication Date
KR19990036081A true KR19990036081A (ko) 1999-05-25

Family

ID=8219499

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980700747A KR19990036081A (ko) 1995-08-03 1996-08-02 인간 엠피52 에이알지 단백질

Country Status (15)

Country Link
EP (1) EP0842274A1 (es)
JP (1) JP2000511155A (es)
KR (1) KR19990036081A (es)
CN (1) CN1192237A (es)
AR (1) AR003974A1 (es)
AU (1) AU699708B2 (es)
BR (1) BR9609983A (es)
CA (1) CA2227204A1 (es)
HU (1) HUP9900362A2 (es)
IL (1) IL122817A0 (es)
MX (1) MX9800801A (es)
NO (1) NO980375L (es)
PL (1) PL324822A1 (es)
WO (1) WO1997006254A1 (es)
ZA (1) ZA966489B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
GB9610281D0 (en) * 1996-05-16 1996-07-24 Ralston Stuart H Diagnostic method and apparatus
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
CA2806143A1 (en) 2010-07-30 2012-02-02 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mb H Drug delivery devices and growth factor formulations for accelerated wound healing
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing
EP2602264A1 (en) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5 mutant for inducing cartilage formation
KR101213355B1 (ko) * 2011-12-27 2012-12-18 오스템임플란트 주식회사 초기 안정성이 증진된 치과용 임플란트 및 그 제조 방법
JP2023507007A (ja) 2019-12-18 2023-02-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 疼痛及び軟骨破壊を治療するためのｇｄｆ－５変異体の使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ249113A (en) * 1992-02-12 1996-07-26 Bioph Biotech Entw Pharm Gmbh Recombinant dna encoding tgf-b, its production and pharmaceutical compositions thereof
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
DE4420157B4 (de) * 1993-08-10 2013-04-25 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Neuer Wachstums/Differenzierungsfaktor der TGF-β-Familie
ATE319823T1 (de) * 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen

Also Published As

Publication number Publication date
AR003974A1 (es) 1998-09-30
AU699708B2 (en) 1998-12-10
NO980375D0 (no) 1998-01-28
JP2000511155A (ja) 2000-08-29
MX9800801A (es) 1998-11-29
AU6789196A (en) 1997-03-05
WO1997006254A1 (en) 1997-02-20
NO980375L (no) 1998-01-28
EP0842274A1 (en) 1998-05-20
CN1192237A (zh) 1998-09-02
HUP9900362A2 (hu) 1999-05-28
IL122817A0 (en) 1998-08-16
CA2227204A1 (en) 1997-02-20
PL324822A1 (en) 1998-06-22
ZA966489B (en) 1997-02-26
BR9609983A (pt) 1999-01-12

Similar Documents

Publication Publication Date Title
KR100259827B1 (ko) 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
US5366875A (en) Methods for producing BMP-7 proteins
EP0955313B1 (en) Novel protein and process for producing the same
KR100255417B1 (ko) Bmp-9 조성물
KR100231640B1 (ko) Bmp-10 조성물
US5141905A (en) Dna sequences encoding bmp-7 proteins
FI119696B (fi) BMP-11:tä koodaavat DNA-sekvenssit, valmistusmenetelmä ja käytöt in vitro
US5849880A (en) Bone morphogenetic protein (BMP)--6
CA2169171C (en) New growth/differentiation factor of the tgf-beta family
KR19990014917A (ko) Bmp-15 조성물
JPH06506360A (ja) タンパク質により誘導される形態形成
Tziafas et al. Short-term dentinogenic response of dog dental pulp tissue after its induction by demineralized or native dentine, or predentine
EP1078054B1 (en) Monomeric mp52/gdf-5 with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
KR19990036081A (ko) 인간 엠피52 에이알지 단백질
EP0866125A1 (en) Novel protein hmw human mp52
JPH10194987A (ja) 骨・軟骨形成用組成物
AP856A (en) A novel homodimer protein used in pharmaceutical preparation for treating cartlage and bone diseases.
MXPA98000686A (es) Nueva proteina hmw humana mp52s
KR100247216B1 (ko) 골 유도 조성물
JPH0551400A (ja) 短鎖コラーゲン
MXPA97008011A (es) Nueva proteina y proceso para su preparacion

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid