KR19980703866A - Disinfectant Disinfectant for Throat - Google Patents

Abstract

The present invention relates to a bactericidal disinfectant for throat characterized by containing povidone iodine and glycosyl dipotassium. The present invention has excellent usability and good stability.

Description

Disinfectant Disinfectant for Throat

As a disinfectant disinfectant for the throat with povidone iodine as an active ingredient, it is directly attached to the throat by a recently sprayed or discharged container which is commercially available in addition to a formulation applied directly to the throat, such as a mouthwash in a dilute aqueous solution or a rugol's solution. Known liquids are known.

However, these disinfectant disinfectants for throat have a bitter taste, irritation, burning sensation, so that when used by infants, children, the elderly, etc. are often thirsty, coughing or nausea, the desired effect is not obtained. There was no problem.

As a cause of such a problem, as a problem of povidone iodine itself, besides side effects such as pruritus and burning sensation caused by effective iodine in povidone urea, the amount of volatile substances contained in the preparation, stimulation by base component, and the like are considered.

The problem of povidone iodine itself must be solved in the formulation design, but the compounding ingredients are limited in terms of the properties and stability of the effective iodine.

For example, in order to mask the stimulus of the povidone iodine preparation, when a component generally used in the pharmaceutical formulation, for example, a sweetener such as sucrose, fructose, glucose, lactose, maltose and the like, is added, the nutrient is synergistically decomposed. In addition, in the case of blending the fragrance, the effect can not be obtained if not blended in a large amount, but if they are blended in a large amount, there is a problem in terms of solubility, taste, usability and the like.

Accordingly, an object of the present invention is to provide a disinfectant disinfectant champ for throat that has excellent usability and is stable in povidone iodine.

The present invention relates to a bactericidal disinfectant which has sweetness, improves stimulus and burning sensation, has excellent usability, and further has good stability of the ingredient.

1 is a diagram showing the effect of pH on the stability of effective iodine and dipotassium glycyricitate.

In this situation, the present inventors pay attention to the sweetening and mating action of licorice extract, and examined the possibility of mixing in povidone iodine solution with various extracts, extracts, and other salts, When used in combination, it was found that a sterilizing disinfectant for a throat can be obtained without affecting the sterilization action of povidone iodine, and thus, a stable throat disinfectant.

In addition, the licorice extract has some effect of improving the feeling of use, but since the activity of the effective iodine is lowered, sterilization cannot be obtained, and thus it is difficult to mix. Glycyric acid, monosilicate glycyric acid, monopotassium glycyric acid, glycyrrhetinic acid, stearyl glycyric acid stearyl, and stearic acid glycyryl are less soluble, and the purpose of improving the feeling of use cannot be achieved. It was difficult. In addition, since disodium 3-succinyloxyglycile retinate lowers the activity of the effective iodine, since sterilization cannot be obtained, compounding is difficult.

That is, the present invention is to provide a bactericidal disinfectant for throat characterized in that it contains povidone iodine and glycidyl dipotassium.

In the throat disinfectant for throat of the present invention, povidone iodine is preferably blended at 0.05 to 1 w / v%, in particular, at 0.3 to 0.6 w / v%, in the precursor composition.

In addition, dipotassium glycyric acid is preferably blended at 0.05 to 1 w / v%, especially 0.2 to 0.4 w / v% in the composition, and if it is within this range, it can be obtained that it is sweet and has better usability. .

As the potassium dicytolic acid diacrylate, those described in the Japanese Pharmacy Room Standard or Cosmetic Ingredient Standard can be used.

The antiseptic disinfectant for throat of the present invention is prepared by dissolving povidone iodine and glycosyric acid dipotassium in the base component (solvent). As a base component (solvent) used here, purified water, ethanol, propylene glycol, glycerin, etc. are mentioned, for example, These can be used 1 type or in combination or 2 or more types.

In addition, the bactericidal antiseptic drug for throat of the present invention includes, for example, fennel oil, spearmint oil, dl-camphor, l-menthol, cinnamon oil, peppermint oil, vanillin, strawberry extract and other flavoring agents; Active ingredients such as lysozyme chloride, allantoin, and transnecsamic acid and the like can be suitably blended in a range not impairing the effects of the present invention.

In addition, the bactericidal disinfectant for a throat of the present invention is preferably at a pH of 3 to 5, particularly at a pH of 3.5 to 4.5, because the stability of povidone iodide and glycosyric acid dipotassium is further enhanced. As the pH adjuster used to adjust the pH here, for example, inorganic acids such as hydrochloric acid, boric acid, phosphoric acid, organic acids such as acetic acid, lactic acid, citric acid, ascorbic acid, disodium citrate, potassium dihydrogen phosphate, amino acetic acid, etc. Can be mentioned. What is necessary is just to add the quantity of these pH adjusters necessary for setting it as desired pH.

The antiseptic disinfectant for throat of the present invention is prepared by dissolving povidone iodine and glycositrate dipotassium in a mixture of ethanol and purified water, stirring by adding concentrated glyceryl, and adjusting the pH to 3-5 with a pH adjuster. It is preferable.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Example 1.

A bactericidal disinfectant for throat having the composition shown in Table 1 was prepared, and a sensory test by taste was performed. The results are shown in Table 2.

(quite)

Povidone iodine, dipotassium glycyric acid, potassium iodide, and l-menthol were dissolved in a mixed solution of ethanol and purified water, concentrated glycerin and hydrochloric acid were added, stirred, and 100 ml of purified water was used.

(Sensory test method)

Each bactericidal disinfectant is packed into a simple divided container (25 ml), and the taste of the two direct panelists when exposed directly to the throat is unpleasant bitter, bitter, slightly bitter, slightly sweet and It was evaluated as one of the unpleasant sweetness, and the result was expressed by his number of people.

ingredient Invention Comparative product One 2 3 4 Povidone-iodine glycidyl dipotassium potassium iodide 1-menthol concentrate glycerin ethanol hydrochloric acid 0.45 g0.05 g1.0 g0.3 g80.0 g 15.0 g quantity * total 100 ml 0.45 g0.2 g1.0 g0.3 g80.0 g15.0 g quantity * total 100 ml 0.45 g0.5 g1.0 g0.3 g80.0 g15.0 g quantity * total 100 ml 0.45 g1.0 g1.0 g0.3 g80.0 g 15.0 g quantity * total 100 ml 0.45 g-1.0 g 0.3 g 80.0 g 15.0 g quantity * total 100 ml

Answer (person) Invention Comparative product One 2 3 4 It has an unpleasant bitter taste. 0 0 0 0 One It has a bitter taste. 0 0 0 0 4 It is slightly bitter. One 0 0 0 2 It is slightly sweet. 3 One One 0 0 It is sweet. 3 6 6 6 0 It has an unpleasant sweetness. 0 0 0 One 0

As is apparent from the results in Table 2, the comparative product which did not contain dipotassium glycidyl titanate had a bitter taste, and the present invention which blended 0.05 to 1.0 w / v% of dipotassium glycidyl titanate with respect to poor usability. All have sweet taste and showed excellent usability.

Example 2

Throat bactericidal disinfectants of the compositions shown in Table 3 were prepared in the same manner as in Example 1 to pH 2 to 6. The effect on the stability of effective iodine and glycidyl titanic acid potassium by pH when it was preserve | saved at 60 degreeC for 1 week was investigated. The results are shown in Figure 1 by the residual rate.

ingredient Invention 5 6 Povidone Iodiglycidyl Litrate Dipotassium Potassium Iodide 1- Menthol Glycerin Ethanol pH 0.2 g0.2 g1.0 g0.3 g80.0 g15.0 g total hydrochloric acid 100 ml 0.2 g0.2 g1.0 g0.3 g80.0 g15.0 g total citric acid 100 ml

As is apparent from the results of Figure 1, the bactericidal disinfectant for throat of the present invention is effective in the stability of the effective iodine in the pH range of 3 to 5, the pH is worse inclined toward the alkali side, the stability of dipotassium glycidyl lysate is inclined toward the acidic side It becomes bad, and a positive component shows the opposite behavior of stability, but sufficient stability is obtained in this range.

Example 3

A bactericidal disinfectant for throat of the composition shown in Table 4 was prepared in the same manner as in Example 1, and a sensory test by taste was performed in the same manner as in Example 1. The results are shown in Table 5.

ingredient Invention 7 8 9 10 Povidone-iodine glycidyl dipotassium potassium iodide 1-menthol concentrate glycerin ethanol hydrochloric acid 0.05 g 0.2 g 1.0 g 0.3 g 80.0 g 15.0 g quantity * total 100 ml 0.1 g0.2 g1.0 g0.3 g80.0 g15.0 g quantity * total 100 ml 0.7 g 0.2 g 1.0 g 0.3 g 80.0 g 15.0 g quantity * total 100 ml 1.0 g0.2 g1.0 g0.3 g80.0 g15.0 g quantity * total 100 ml

*: amount to pH 4

Answer (person) Invention 7 8 9 10 It has an unpleasant bitter taste. 0 0 0 0 It has a bitter taste. 0 0 0 0 It is slightly bitter. 0 0 0 0 It is slightly sweet. 0 One 0 2 It is sweet. 7 6 7 5 It has an unpleasant sweetness. 0 0 0 0

As apparent from the results in Table 5, all of the present invention was sweet, excellent in use, and excellent in stability.

The antiseptic disinfectant for throat of the present invention has sweetness, improves stimulus and burning sensation, is excellent in use, and has good stability of components.

Claims (6)

A bactericidal disinfectant for throat, comprising povidone iodine and glycosyl dipotassium. The throat disinfectant for throat according to claim 1, wherein the povidone iodine contains 0.05 to 1 w / v% and 0.05 to 1 w / v% of dipotassium glycyric acid. The throat disinfectant for throat according to claim 1 or 2, wherein the pH is 3 to 5. The disinfectant disinfectant for throat according to any one of claims 1 to 3, further comprising a solvent. The disinfectant disinfectant for throat according to claim 4, wherein the solvent is one or more selected from the group consisting of water, ethanol, propylene glycol and glycerin. The disinfectant disinfectant for throat according to any one of claims 1 to 5, further comprising a solvating agent, a flavoring agent, a flavoring agent, and an anti-inflammatory agent.