WO1996035434A1 - Laryngeal bactericidal and antiseptic composition - Google Patents

Laryngeal bactericidal and antiseptic composition Download PDF

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Publication number
WO1996035434A1
WO1996035434A1 PCT/JP1996/001175 JP9601175W WO9635434A1 WO 1996035434 A1 WO1996035434 A1 WO 1996035434A1 JP 9601175 W JP9601175 W JP 9601175W WO 9635434 A1 WO9635434 A1 WO 9635434A1
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Prior art keywords
throat
disinfectant
composition
glycyrrhizinate
present
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PCT/JP1996/001175
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French (fr)
Japanese (ja)
Inventor
Toshio Inagi
Makoto Kanebako
Yasuhiro Shinkawa
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Kowa Co., Ltd.
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Priority to AU55151/96A priority Critical patent/AU5515196A/en
Publication of WO1996035434A1 publication Critical patent/WO1996035434A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the present invention relates to a disinfectant composition for throat for the throat, which has a sweet taste, has an improved irritation and burning sensation, is excellent in use sensation, and has good component stability.
  • Throat disinfectants containing bovidonodo as an active ingredient include gargles as a dilute aqueous solution, preparations that are directly applied to the throat such as Lugol's solution, as well as simple spray or discharge containers recently launched on the market. Liquids that are directly adhered to are known. However, these throat disinfectants have a pungent, irritating, burning sensation, etc., and when used by infants, children, elderly people, etc., they may be choppy, squeezed, or exhaled In many cases, the intended effect was not sufficiently obtained.
  • the causes of such problems include povidone oxide itself, pruritus, burning sensation, etc. due to available iodine in povidone chloride, the amount of volatile substances contained in the drug product, base ingredients Stimulation due to is considered.
  • an object of the present invention is to provide a disinfectant composition for throat which is excellent in feeling of use and stable in povidone. Disclosure of the invention Under such circumstances, the present inventors have paid attention to the sweetness and taste-correcting action of the Kanzo extract, and examined the possibility of blending various extracts, extractable components, and other salts in a povidonodo solution, and found that povidonodo and dipotassium glycyrrhizinate were added. It has been found that when used in combination, a germicidal disinfectant for the throat that is excellent in the usability and stable can be obtained without affecting the bactericidal action of povidonodo.
  • the kanzo extract has an effect of improving the feeling of use, the activity of effective iodine was reduced, so that it was difficult to obtain a bactericidal effect, and it was difficult to mix it.
  • Glycyrrhizic acid, monoammonium glycyrrhizinate, monopotassium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate and glycyrrhetinyl stearate were too small to dissolve and could not be blended because the purpose of improving the usability was not achieved. there were. Further, with regard to ninadium 3-succinyloxyglycyrrhetinate, it was difficult to mix bactericidal action due to the reduction of the activity of effective iodine.
  • the present invention provides a germicidal antiseptic composition for throat, characterized by containing povidonodo and dipotassium glycyrrhizinate.
  • FIG. 1 is a graph showing the effect of pH on the stability of available iodine and dicalcium glycyrrhizinate.
  • povidonodo is incorporated in the entire composition in an amount of 0.05 to 1% by weight Z volume%, particularly 0.3 to 0.6% by weight Z volume%.
  • the glycyrrhizic acid diammonium be incorporated in the entire composition in an amount of 0.05 to 1% by weight Z volume%, particularly 0.2 to 0.4% by weight volume. Yes, with better usability.
  • the germicidal antiseptic composition for throat of the present invention is produced by dissolving povidone and dicalidium glycyrrhizinate in a base component (solvent).
  • a base component solvent
  • examples of the base component (solvent) used here include water, ethanol, propylene glycol, glycerin and the like, and one or more of these can be used in combination.
  • the throat disinfectant disinfectant composition of the present invention may further comprise, in addition to the above essential components, for example, fennel oil, spare mint oil, camphor, menthol, keich oil, oil, vanillin, strawberry extract and the like.
  • An active ingredient represented by an anti-inflammatory agent such as lysozyme chloride, alantoin, tranexamic acid and the like can be appropriately compounded as long as the effect of the present invention is not impaired.
  • an alkali metal iodide represented by potassium iodide can be blended as a solubilizer.
  • both the stability of povidonide and dipotassium glycyrrhizinate are preferably higher.
  • the pH adjuster used to adjust the pH include inorganic acids such as hydrochloric acid, boric acid, and phosphoric acid, organic acids such as acetic acid, lactic acid, and citric acid, ascorbic acid, and disodium citrate. And buffering agents such as potassium dihydrogen phosphate and aminoaminoacetic acid. These pH adjusters may be added in an amount necessary to obtain a desired pH.
  • the throat disinfectant composition for throat of the present invention is prepared by dissolving povidone and diglycidyl glycyrrhizinate in a solvent such as a mixture of ethanol and water, adding another solvent such as concentrated glycerin, stirring, and then using a pH adjuster. It is preferred to produce by adjusting the pH to 3-5.
  • a throat disinfectant having the composition shown in Table 1 was manufactured and subjected to a sensory test by taste.
  • Table 2 shows the results. (Formulation method)
  • a throat disinfectant having a composition shown in Table 3 was produced in the same manner as in Example 1 by adjusting the pH to 2 to 6.
  • the effect of pH on the stability of available iodine and diglyceryl glycyrrhizinate when stored at 60 ° C for 1 week was examined. The results are shown in FIG.
  • the stability of the effective iodine in the throat disinfectant of the present invention in the pH range of 3 to 5 deteriorates as the pH inclines toward pH.
  • the stability of the dike rim deteriorates as the pH shifts toward the acidic side, and both components show opposing stability behaviors, but within this range, sufficient stability can be obtained.
  • Example 4 A throat disinfectant having the composition shown in Table 4 was produced in the same manner as in Example 1, and a sensory test by taste was conducted in the same manner as in Example 1. Table 5 shows the results. Table 4
  • the germicidal antiseptic composition for throat of the present invention has a sweet taste, an improved irritation and burning sensation, an excellent feeling in use, and a good stability of the components.

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Abstract

A laryngeal bactericidal and antiseptic composition containing povidone-iodine and dipotassium glycyrrhizinate, being comfortable for use, and having an excellent stability.

Description

明 細 書  Specification
喉用殺菌消毒薬組成物 技術分野  Throat disinfectant composition Technical field
本発明は、 甘味を有し、 刺激及び灼熱感が改善され、 使用感に優れ、 しかも成 分の安定性が良好な喉用殺菌消毒薬組成物に関する。 背景技術  TECHNICAL FIELD The present invention relates to a disinfectant composition for throat for the throat, which has a sweet taste, has an improved irritation and burning sensation, is excellent in use sensation, and has good component stability. Background art
ボビドンョードを有効成分とする喉用殺菌消毒薬としては、 希釈水溶液として のうがい薬や、 ルゴール液のように直接喉に塗布する製剤の他、 近年上市された、 簡易噴霧型あるいは吐出型容器により、 喉に直接付着させる液剤が知られている。 しかしながら、 これらの喉用殺菌消毒薬は、 辛味、 刺激感、 灼熱感などがある ため、 幼児、 子供、 老人などが使用する場合には、 むせたり、 せき込んだり、 吐 き出したりしてしまうことが多く、 目的とする効果が充分に得られないという問 題があった。  Throat disinfectants containing bovidonodo as an active ingredient include gargles as a dilute aqueous solution, preparations that are directly applied to the throat such as Lugol's solution, as well as simple spray or discharge containers recently launched on the market. Liquids that are directly adhered to are known. However, these throat disinfectants have a pungent, irritating, burning sensation, etc., and when used by infants, children, elderly people, etc., they may be choppy, squeezed, or exhaled In many cases, the intended effect was not sufficiently obtained.
このような問題の原因としては、 ポビドンョード自体の問題として、 ポビドン ョ一ド中の有効ヨウ素による搔痒感、 灼熱感などの副作用の他、 製剤中に含まれ る揮発性物質の量、 基剤成分による刺激などが考えられている。  The causes of such problems include povidone oxide itself, pruritus, burning sensation, etc. due to available iodine in povidone chloride, the amount of volatile substances contained in the drug product, base ingredients Stimulation due to is considered.
ポビドンョ一ド自体の問題は、 製剤設計上において解決しなければならないが、 有効ョゥ素の性質、 安定性などの点から配合成分が制限されていた。  The problem of Povidonide itself had to be solved in the formulation design, but the ingredients were limited in terms of the properties and stability of effective iodine.
例えば、 ポビドンョード製剤の刺激をマスクするために、 製剤学上一般的に用 いられている成分、 例えば甘味料としてショ糖、 果糖、 ブドウ糖、 乳糖、 麦芽糖 などの糖類を配合すると、 両成分が相剰的に分解してしまう。 また、 香料を配合 する場合には、 多量に配合しないと効果が得られないが、 これらを多量に配合す ると、 溶解性、 味、 使用感などの点で問題が生じてくる。  For example, in order to mask the irritation of povidon-dode preparations, if ingredients commonly used in pharmacology, such as sucrose, fructose, glucose, lactose, maltose, etc., are added as sweeteners, both components will be compatible. Decomposes excessively. In addition, when fragrances are blended, the effect cannot be obtained unless they are blended in a large amount. However, if these are blended in a large amount, problems arise in terms of solubility, taste, and feeling in use.
従って、 本発明の目的は、 使用感に優れ、 しかもポビドンョードが安定な喉用 殺菌消毒薬組成物を提供することにある。 発明の開示 かかる実情において、 本発明者らはカンゾゥエキスの甘味と矯味作用に注目し、 各種エキス類、 抽出成分、 その他塩類について、 ポビドンョード溶液中への配合 の可能性を検討した結果、 ポビドンョードとグリチルリチン酸ジカリウムを組合 わせて用いれば、 ポビドンョードの殺菌作用に影響することがなく、 使用感に優 れ、 しかも安定な喉用殺菌消毒薬が得られることを見出し、 本発明を完成した。 また、 カンゾゥエキス類については、 使用感の改善効果はあるものの、 有効ョ ゥ素の活性を低下させてしまうため殺菌作用が得られなくなること力、ら、 配合は 困難であった。 グリチルリチン酸、 グリチルリチン酸モノアンモニゥ厶、 グリチ ルリチン酸モノカリウム、 グリチルレチン酸、 グリチルレチン酸ステアリル及び ステアリン酸グリチルレチニルについては、 溶解量が少なく使用感を改善する目 的が達成できなかったとこから、 配合は困難であった。 更に、 3—サクシニルォ キシグリチルレチン酸ニナトリゥ厶については、 有効ヨウ素の活性を低下させる ため殺菌作用が得られなくなること力、ら、 配合は困難であった。 Therefore, an object of the present invention is to provide a disinfectant composition for throat which is excellent in feeling of use and stable in povidone. Disclosure of the invention Under such circumstances, the present inventors have paid attention to the sweetness and taste-correcting action of the Kanzo extract, and examined the possibility of blending various extracts, extractable components, and other salts in a povidonodo solution, and found that povidonodo and dipotassium glycyrrhizinate were added. It has been found that when used in combination, a germicidal disinfectant for the throat that is excellent in the usability and stable can be obtained without affecting the bactericidal action of povidonodo. In addition, although the kanzo extract has an effect of improving the feeling of use, the activity of effective iodine was reduced, so that it was difficult to obtain a bactericidal effect, and it was difficult to mix it. Glycyrrhizic acid, monoammonium glycyrrhizinate, monopotassium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate and glycyrrhetinyl stearate were too small to dissolve and could not be blended because the purpose of improving the usability was not achieved. there were. Further, with regard to ninadium 3-succinyloxyglycyrrhetinate, it was difficult to mix bactericidal action due to the reduction of the activity of effective iodine.
すなわち、 本発明は、 ポビドンョード及びグリチルリチン酸ジカリウムを含有 することを特徴とする喉用殺菌消毒薬組成物を提供するものである。 図面の簡単な説明  That is, the present invention provides a germicidal antiseptic composition for throat, characterized by containing povidonodo and dipotassium glycyrrhizinate. BRIEF DESCRIPTION OF THE FIGURES
図 1は、 有効ヨウ素及びグリチルリチン酸ジカリゥ厶の安定性に対する pHの影 響を示す図である。 発明を実施するための最良の形態  FIG. 1 is a graph showing the effect of pH on the stability of available iodine and dicalcium glycyrrhizinate. BEST MODE FOR CARRYING OUT THE INVENTION
本発明の喉用殺菌消毒薬組成物において、 ポビドンョードは全組成中に 0 . 0 5〜 1重量 Z容量％、 特に 0 . 3〜0 . 6重量 Z容量％配合するのが好ま しい。  In the germicidal antiseptic composition for throat of the present invention, it is preferable that povidonodo is incorporated in the entire composition in an amount of 0.05 to 1% by weight Z volume%, particularly 0.3 to 0.6% by weight Z volume%.
また、 グリチルリチン酸ジ力リゥムは、 全組成中に 0 . 0 5〜 1重量 Z容量％、 特に 0 . 2〜0 . 4重量 容量％配合するのが好ましく、 この範囲内であると、 甘味があり、 使用感がより優れたものが得られる。  It is preferable that the glycyrrhizic acid diammonium be incorporated in the entire composition in an amount of 0.05 to 1% by weight Z volume%, particularly 0.2 to 0.4% by weight volume. Yes, with better usability.
なお、 グリチルリチン酸ジカリウムとしては、 日本薬局方タ規準又は化粧品原 料基準に記載されているものを使用することができる。 本発明の喉用殺菌消毒薬組成物は、 基剤成分 （溶剤） にポビドンョード及びグ リチルリチン酸ジカリゥ厶を溶解することにより製造される。 ここで用いられる 基剤成分 （溶剤） としては、 例えば水、 エタノール、 プロピレングリコール、 グ リセリン等が挙げられ、 これらの 1種又は 2種以上を組合わせて用いることがで きる。 As the dipotassium glycyrrhizinate, those described in the Japanese Pharmacopoeia Standard or the Cosmetic Raw Material Standard can be used. The germicidal antiseptic composition for throat of the present invention is produced by dissolving povidone and dicalidium glycyrrhizinate in a base component (solvent). Examples of the base component (solvent) used here include water, ethanol, propylene glycol, glycerin and the like, and one or more of these can be used in combination.
また、 本発明の喉用殺菌消毒薬組成物には、 前記必須成分の他、 例えばウイキ ヨウ油、 スペアミ ント油、 —カンフル、 £—メントール、 ケィヒ油、 ノヽッ力 油、 バニリン、 ストロベリーエキス等の着香剤、 香料；塩化リゾチーム、 ァラン トイン、 トラネキサム酸等の抗炎症剤に代表される活性成分などを、 本発明の効 果を損わない範囲で適宜配合することができる。 また、 ヨウ化カリウムに代表さ れるヨウ化アルカリ金属を溶解補助剤として配合することができる。  In addition, the throat disinfectant disinfectant composition of the present invention may further comprise, in addition to the above essential components, for example, fennel oil, spare mint oil, camphor, menthol, keich oil, oil, vanillin, strawberry extract and the like. An active ingredient represented by an anti-inflammatory agent such as lysozyme chloride, alantoin, tranexamic acid and the like can be appropriately compounded as long as the effect of the present invention is not impaired. Further, an alkali metal iodide represented by potassium iodide can be blended as a solubilizer.
更に、 本発明の喉用殺菌消毒薬は、 pHが 3〜5、 特に pH 3 . 5〜4 . 5である と、 ポビドンョ一ド及びグリチルリチン酸ジカリウムの安定性がともに、 より高 くなり好ましい。 ここで、 pHを調整するのに用いられる pH調整剤としては、 例え ば塩酸、 ホウ酸、 リン酸などの無機酸、 酢酸、 乳酸、 クェン酸などの有機酸、 ァ スコルビン酸、 クェン酸ニナトリウム、 リン酸ニ水素力リウ厶、 ァミノ酢酸など の緩衝剤が挙げられる。 これらの pH調整剤は、 所望の pHにするのに必要な量を添 加すればよい。  Furthermore, when the pH of the disinfectant for disinfecting the throat of the present invention is 3 to 5, particularly 3.5 to 4.5, both the stability of povidonide and dipotassium glycyrrhizinate are preferably higher. Here, examples of the pH adjuster used to adjust the pH include inorganic acids such as hydrochloric acid, boric acid, and phosphoric acid, organic acids such as acetic acid, lactic acid, and citric acid, ascorbic acid, and disodium citrate. And buffering agents such as potassium dihydrogen phosphate and aminoaminoacetic acid. These pH adjusters may be added in an amount necessary to obtain a desired pH.
本発明の喉用殺菌消毒薬組成物は、 例えばエタノール及び水の混液等の溶剤に ポビドンョード及びグリチルリチン酸ジ力リゥムを溶解し、 濃グリセリン等の他 の溶剤を加えて攪拌し、 pH調整剤で pHを 3〜 5に調整することにより製造するの が好ましい。 実施例  The throat disinfectant composition for throat of the present invention is prepared by dissolving povidone and diglycidyl glycyrrhizinate in a solvent such as a mixture of ethanol and water, adding another solvent such as concentrated glycerin, stirring, and then using a pH adjuster. It is preferred to produce by adjusting the pH to 3-5. Example
次に、 実施例を挙げて本発明を更に説明するが、 本発明はこれら実施例に限定 されるものではない。  Next, the present invention will be further described with reference to examples, but the present invention is not limited to these examples.
実施例 1 Example 1
表 1に示す組成の喉用殺菌消毒薬を製造し、 味覚による官能試験を行った。 結 果を表 2に示す。 (製法） A throat disinfectant having the composition shown in Table 1 was manufactured and subjected to a sensory test by taste. Table 2 shows the results. (Formulation method)
ェ夕ノール及び精製水の混合液にポビドンョード、 グリチルリチン酸ジ力リゥ 厶、 ヨウ化カリウム及び^一メントールを溶解し、 濃グリセリン及び塩酸を加え て攪拌し、 精製水で 1 0 とした。  In a mixed solution of ethanol and purified water, povidone oxide, diammonium glycyrrhizinate, potassium iodide and menthol were dissolved, concentrated glycerin and hydrochloric acid were added, and the mixture was stirred to make 10 with purified water.
(官能試験方法）  (Sensory test method)
各殺菌消毒薬を簡易噴霧型容器 に充塡し、 7名のパネラーが喉に 2 回直射したときの味覚を、 「不快な辛味がある」 、 「辛味がある」 、 「やや辛味 がある」 、 「やや甘味がある」 σϋ、 「甘味がある」 及び 「不快な甘味がある」 のい ずれかで評価し、 結果をその人数で示した。  Fill each simple disinfectant into a simple spray-type container, and taste the taste when seven panelists hit the throat twice, with “unpleasant pungent”, “spicy”, “slightly spicy” , "Slightly sweet" σϋ, "sweet" and "unpleasant sweet" were evaluated, and the results were shown by the number of persons.
表 1 本 発 明 比較 on 成 分  Table 1 Comparison of the present invention on components
2 4  twenty four
ポビドンョード 0. 45g 0. 45g 0. 45g 0. 45g 0. 45g グリチルリチン酸 0. 05g 0. 2g 0. 5g l. Og  Povidonodo 0.45 g 0.45 g 0.45 g 0.45 g 0.45 g glycyrrhizic acid 0.05 g 0.2 g 0.5 g l. Og
ジカリウ厶  Gycadium
ヨウ化力リウム l. Og l. Og l. Og l. Og ーメントール 0. 3g 0. 3g 0. 3g 0. 3g 0. 3g 濃グリセリン 80. Og 80. Og 80. Og 80. Og 80. Og エタノール 15. Og 15. Og 15. Og 15. 0 15. Og 塩酸 mm* mm* M * MM * 適 fi * 精製水 全 10(½ 全 全 100m£ 全 全  Potassium iodide l. Og l. Og l. Og l. Og-menthol 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g concentrated glycerin 80. Og 80. Og 80. Og 80. Og 80. Og ethanol 15.Og 15.Og 15.Og 15.0 15.Og Hydrochloric acid mm * mm * M * MM * Suitable fi * Purified water Total 10 (½ Total 100m £ Total All
* : pH 4になる量  *: Amount to reach pH 4
表 2 本 発 明 品  Table 2 Invented products
回 答 （人） 比較品  Answer (person) Comparative product
1 2 3 4  1 2 3 4
不快な辛味がある 0 0 0 0 1  There is unpleasant pungency 0 0 0 0 1
辛味がある 0 0 0 0 4  Hot 0 0 0 0 4
やや辛味がある 1 0 0 0 2  Somewhat hot 1 0 0 0 2
やや甘味がある 3 1 1 0 0  Somewhat sweet 3 1 1 0 0
甘味がある 3 6 6 6 0  Sweet 3 6 6 6 0
不快な甘味がある 0 0 0 1 0 表 2の結果から明らかなように、 グリチルリチン酸ジカリゥ厶を配合しない比 較品では、 辛味があり、 使用感が悪かったのに対し、 グリチルリチン酸ジカリゥ ムを 0 . 0 5〜1 . 0重量ノ容量％配合した本発明品では、 いずれも甘味があり、 優れた使用感を示した。 There is unpleasant sweetness 0 0 0 1 0 As is evident from the results in Table 2, the comparison product containing no dicalidium glycyrrhizinate had a pungent taste and an uncomfortable feeling, whereas 0.05-1.0 wt% All of the products of the present invention in which volume% was blended had a sweet taste and showed an excellent feeling in use.
実施例 2 Example 2
表 3に示す組成の喉用殺菌消毒薬を実施例 1と同様にして、 pH 2〜6に調整し て製造した。 これを、 6 0 °Cで 1週間保存したときの、 pHによる有効ヨウ素及び グリチルリチン酸ジ力リゥムの安定性に対する影響を調べた。 結果を残存率で図 1に示す。  A throat disinfectant having a composition shown in Table 3 was produced in the same manner as in Example 1 by adjusting the pH to 2 to 6. The effect of pH on the stability of available iodine and diglyceryl glycyrrhizinate when stored at 60 ° C for 1 week was examined. The results are shown in FIG.
表 3  Table 3
Figure imgf000007_0001
図 1の結果から明らかなように、 本発明の喉用殺菌消毒薬は、 pH 3〜5の範囲 において、 有効ヨウ素の安定性は pHがアル力リ側に傾くにつれて悪くなるが、 グ リチルリチン酸ジ力リゥムの安定性は pHが酸性側に傾くにつれて悪くなり、 両成 分は相反する安定性の挙動を示したが、 この範囲であれば、 充分な安定性が得ら れる。
Figure imgf000007_0001
As is evident from the results in FIG. 1, the stability of the effective iodine in the throat disinfectant of the present invention in the pH range of 3 to 5 deteriorates as the pH inclines toward pH. The stability of the dike rim deteriorates as the pH shifts toward the acidic side, and both components show opposing stability behaviors, but within this range, sufficient stability can be obtained.
実施例 3 Example 3
表 4に示す組成の喉用殺菌消毒薬を実施例 1と同様にして製造し、 実施例 1と 同様に味覚による官能試験を行った。 結果を表 5に示す。 表 4A throat disinfectant having the composition shown in Table 4 was produced in the same manner as in Example 1, and a sensory test by taste was conducted in the same manner as in Example 1. Table 5 shows the results. Table 4
Figure imgf000008_0001
Figure imgf000008_0001
* : pH 4になる量 表 5 *: Amount to reach pH 4 Table 5
Figure imgf000008_0002
Figure imgf000008_0002
表 5の結果から明らかなように、 本発明品はいずれも甘味があり、 使用感に優 れたものであり、 また、 安定性にも優れたものであった。 産業上の利用分野  As is evident from the results in Table 5, the products of the present invention all had a sweet taste, were excellent in usability, and were also excellent in stability. Industrial applications
本発明の喉用殺菌消毒薬組成物は、 甘味を有し、 刺激及び灼熱感が改善され、 使用感に優れるとともに、 成分の安定性も良好なものである。  The germicidal antiseptic composition for throat of the present invention has a sweet taste, an improved irritation and burning sensation, an excellent feeling in use, and a good stability of the components.

Claims

請 求 の 範 囲 The scope of the claims
1 . ポビドンョード及びグリチルリチン酸ジカリゥ厶を含有することを特徴とす る喉用殺菌消毒薬組成物。  1. A throat disinfectant disinfectant composition comprising povidonodo and dicalium glycyrrhizinate.
2 . ポビドンョ一ドを 0 . 0 5〜 1重量 容量％、 グリチルリチン酸ジカリウム を 0 . 0 5〜 1重量 Z容量％含有する請求項 1記載の喉用殺菌消毒薬組成物。 2. The disinfectant composition for throat for throat according to claim 1, which contains 0.05 to 1% by weight of povidone chloride and 0.05 to 1% by weight of Z potassium volume of dipotassium glycyrrhizinate.
3 . pHが 3〜 5である請求項 1又は 2記載の喉用殺菌消毒薬組成物。 3. The germicidal antiseptic composition for throat according to claim 1 or 2, wherein the pH is 3-5.
4 . 更に溶剤を含有するものである請求項 1〜 3のいずれか 1項記載の喉用殺菌 消毒薬組成物。  4. The disinfectant composition for throat according to any one of claims 1 to 3, further comprising a solvent.
5 . 溶剤が、 水、 エタノール、 プロピレングリコール及びグリセリンから選ばれ る 1種又は 2種以上である請求項 4記載の喉用殺菌消毒薬組成物。  5. The throat disinfectant disinfectant composition according to claim 4, wherein the solvent is one or more selected from water, ethanol, propylene glycol and glycerin.
6 . 更に、 溶解補助剤、 着香剤、 香料及び抗炎症剤から選ばれる成分を含有する ものである請求項 1〜 5のいずれか 1項記載の喉用殺菌消毒薬組成物。  6. The germicidal antiseptic composition for throat according to any one of claims 1 to 5, further comprising a component selected from a solubilizing agent, a flavoring agent, a fragrance, and an anti-inflammatory agent.
PCT/JP1996/001175 1995-05-08 1996-04-26 Laryngeal bactericidal and antiseptic composition WO1996035434A1 (en)

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JP7/109350 1995-05-08
JP7109350A JPH08301774A (en) 1995-05-08 1995-05-08 Throat disinfectant

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US6640988B2 (en) 2000-06-28 2003-11-04 Saad Taha Container closure
KR100613706B1 (en) * 1998-05-27 2006-08-21 유로-셀띠끄 소시에떼 아노님 Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the upper respiratory tract and/or the ear

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Publication number Priority date Publication date Assignee Title
JP4084329B2 (en) * 2004-03-31 2008-04-30 小林製薬株式会社 Liquid composition and method for producing the same
CN102526176B (en) * 2012-01-21 2013-10-30 保定冀中药业有限公司 Oral administration mineral medicine manufactured by liquorice aqueous extracts
JP6320616B1 (en) * 2017-08-22 2018-05-09 ヴェローチェ・バイオファーマ・エルエルシー Novel ophthalmic compositions and methods of use

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JPS58152808A (en) * 1982-03-05 1983-09-10 Kiyuushin Seiyaku Kk Collutorium composition
JPH06172192A (en) * 1992-12-10 1994-06-21 Masaya Ootsuka Aqueous disinfectant for vaginal and intraoral mucosa
JPH07330619A (en) * 1994-06-10 1995-12-19 Kobayashi Pharmaceut Co Ltd Iodine formulation containing perfume blended therein

Patent Citations (3)

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JPS58152808A (en) * 1982-03-05 1983-09-10 Kiyuushin Seiyaku Kk Collutorium composition
JPH06172192A (en) * 1992-12-10 1994-06-21 Masaya Ootsuka Aqueous disinfectant for vaginal and intraoral mucosa
JPH07330619A (en) * 1994-06-10 1995-12-19 Kobayashi Pharmaceut Co Ltd Iodine formulation containing perfume blended therein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100613706B1 (en) * 1998-05-27 2006-08-21 유로-셀띠끄 소시에떼 아노님 Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the upper respiratory tract and/or the ear
US6640988B2 (en) 2000-06-28 2003-11-04 Saad Taha Container closure

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CN1183724A (en) 1998-06-03
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JPH08301774A (en) 1996-11-19
AU5515196A (en) 1996-11-29
KR19980703866A (en) 1998-12-05

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