CN1183724A - Laryngeal bactericidal and antiseptic composition - Google Patents
Laryngeal bactericidal and antiseptic composition Download PDFInfo
- Publication number
- CN1183724A CN1183724A CN96193782A CN96193782A CN1183724A CN 1183724 A CN1183724 A CN 1183724A CN 96193782 A CN96193782 A CN 96193782A CN 96193782 A CN96193782 A CN 96193782A CN 1183724 A CN1183724 A CN 1183724A
- Authority
- CN
- China
- Prior art keywords
- iodine
- povidone
- laryngeal
- disinfecting
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
A laryngeal bactericidal and antiseptic composition containing povidone-iodine and dipotassium glycyrrhizinate, being comfortable for use, and having an excellent stability.
Description
The present invention relates to a kind of disinfecting, antimicrobial compositions that is used for throat, it have sweet taste, zest and burn sense less, feel very good when using, and said composition stability is fine.
Knownly contain the Liniment that povidone-iodine comprises the collutory that uses with the dilute aqueous solution form as disinfecting, antimicrobial example effective ingredient, that be used for throat and is directly used in throat, as Lugol solution, and listing recently, be directly used in the liquid preparation of throat by using simple spraying or aerosol container.
Yet, these disinfecting, antimicrobial medicines that are used for throat in use, it stimulates taste, zest and burns sense and brought problem, suffocate, cough or vomit and can cause when the crowd of their sensitivities such as baby, child or old people used, so its drug effect is not so good as the ideal of expecting.
Itch except causing of available iodine in the povidone-iodine is perverse and burn sense, the side effect that the zest of the content of volatile material and matrix components causes in povidone-iodine itself, the preparation influences to some extent to the problems referred to above.
In design preparation process, the problem of povidone-iodine itself must overcome.On the other hand, in the preparation composition of blending be subjected to available iodine character and stability restriction.
When a kind of medicinal ingredient, when for example sweeting agent such as sucrose, fructose, glucose, lactose or maltose were added into the zest of covering povidone-iodine, composition that these mix and effective ingredient povidone-iodine can thoroughly decompose together.When mixing correctives, have only a large amount of addings that effect is just arranged, bring problem for dissolubility, taste and mouthfeel when using but add affiliation in a large number.
Therefore, the purpose of this invention is to provide a kind of disinfecting, antimicrobial compositions of medicinal throat, mouthfeel is very good and povidone-iodine wherein is very stable in use for it.
Consider the problems referred to above, the inventor find Radix Glycyrrhizae have sweet taste and flavoring character and studied in the polyvinyl pyrrolidone iodine solution, mix different types of Radix Glycyrrhizae, from the probability of the composition that wherein extracts, its salt etc.The result shows, can share the fabulous and stable laryngeal disinfecting, antimicrobial compositions of mouthfeel when obtaining using by povidone-iodine and glycyrrhizic acid dipotassium, and the two share the antibacterial effect that does not influence povidone-iodine.Therefore, finished the present invention.
The adding of Radix Glycyrrhizae should be able to effectively improve mouthfeel, but reduces the activity of available iodine, so can not obtain antibacterial action.Therefore, be very difficult together with their blending.Because glycyrrhizic acid, ammonium glycyrrhizinate, dipotaccium glycyrrhizate, enoxolone, enoxolone stearyl and stearic acid Radix Glycyrrhizae-idyne ester is poorly soluble, can not reach expected degree to the improvement of mouthfeel.Thereby its blending is very difficult.And 3-succinyl-oxo glycyrrhetate, the activity of reduction available iodine is so can not obtain antibacterial activity.Therefore, its blending is difficult.
Therefore, the invention provides the laryngeal disinfecting, antimicrobial compositions that contains povidone-iodine and glycyrrhizic acid dipotassium.
Fig. 1 is the sketch map of pH to available iodine and glycyrrhizic acid dipotassium stability influence.
In laryngeal disinfecting, antimicrobial composition of the present invention, preferably mix and account for total composition 0.05 to 1w/v%, particularly preferably 0.3 to 0.6w/v% povidone-iodine.
In addition, preferably mix and account for total composition 0.05 to 1w/v%, particularly preferably the dipotassium glycyrrhizinate of 0.2 to 0.4w/v %. In this scope, said composition has sweet taste and obtains excellent mouthfeel.
Can use the dipotassium glycyrrhizinate of listing in Japanese Pharmacopoeia or the Japanese cosmetic ingredient standard.
Laryngeal disinfecting, antimicrobial composition of the present invention can prepare by povidone-iodine and dipotassium glycyrrhizinate are dissolved in the matrix (solvent). The example of matrix (solvent) comprises water, ethanol, polyethylene glycol and glycerine. They can be used alone or as a mixture.
In laryngeal disinfecting, antimicrobial compositions of the present invention, except above-mentioned basis, the active component that also can add the correctives that do not destroy effect amount of the present invention or flavouring agent such as fennel oil, Oleum menthae, Oleum Camphora, 1-menthol, Oleum Cinnamomi, Oleum menthae, vanillin and Fructus Fragariae Ananssae extract representative, and anti-inflammatory agent example hydrochloric acid lysozyme, allantoin and tranamic acid.In addition, iodate alkali metal salt such as potassium iodide can be used as the cosolvent adding.
In addition, when the pH of laryngeal disinfecting, antimicrobial compositions of the present invention 3 to 5 between (particularly 3.5 to 4.5) time, the stability of povidone-iodine and glycyrrhizic acid dipotassium all makes moderate progress.Therefore, preferred pH is in above-mentioned scope.The pH regulator agent that is suitable for comprises mineral acid example hydrochloric acid, boric acid and phosphoric acid, organic acid such as acetic acid, lactic acid and citric acid, buffer agent such as ascorbic acid, disodium citrate, potassium dihydrogen phosphate and glycine.The addition of these pH regulator agent should be with pH regulator to the scope that will reach.
In order to prepare laryngeal disinfecting, antimicrobial compositions of the present invention, preferably povidone-iodine and glycyrrhizic acid dipotassium are dissolved in solvent such as ethanol and water mixed solution, in gained solution, add another solvent as concentrating glycerol, stir the gained mixture, use then the pH value regulator with the pH regulator of reactant mixture to 3-5.
Embodiment
Describe the present invention in detail with the following example below.But, should recognize not to be to limit the present invention by these embodiment, in other words, not that the present invention is limited in the scope of these embodiment.Embodiment 1
Prepare the laryngeal disinfecting, antimicrobial medicine of component such as table 1 and carry out sense of taste sensory feel result of the test and see Table 2.Preparation method
In the mixed solution of ethanol and pure water, dissolving povidone-iodine, glycyrrhizic acid dipotassium and 1-menthol.In the solution of gained, add concentrated glycerol and hydrochloric acid, stir then.And then adding pure water to cumulative volume is 100ml in mixture.The sensory feel test method
Every kind of disinfecting, antimicrobial medicine is inserted in the simple aerosol type container (25ml).It directly is sprayed to 7 experimenters' throat, sprays twice.The rank of its taste is divided into " pungent taste beastly ", " pungent taste ", " slight pungent taste ", " slight sweet taste ", " sweet taste " and " sweet taste beastly ".Any one that the above-mentioned rank that the result indicates for each member among the experimenter is interior.
Table 1
*: with the scale 2 of pH regulator to 4
Composition | Product of the present invention | Reference product | |||
??????1 | ??????2 | ??????3 | ??????4 | ||
Povidone-iodine | ????0.45g | ????0.45g | ????0.45g | ????0.45g | ????0.45g |
Glycyrrhizic acid dipotassium | ????0.05g | ????0.2g | ????0.5g | ????1.0g | ??????- |
Potassium iodide | ????1.0g | ????1.0g | ????1.0g | ????1.0g | ????1.0g |
The 1-menthol | ????0.3g | ????0.3g | ????0.3g | ????0.3g | ????0.3g |
Concentrate glycerol | ????80.0g | ????80.0g | ????80.0g | ????80.0g | ????80.0g |
Ethanol | ????15.0g | ????15.0g | ????15.0g | ????15.0g | ????15.0g |
Hydrochloric acid | An amount of * | An amount of * | An amount of * | An amount of * | An amount of * |
Pure water | Amount to 100ml | Amount to 100ml | Amount to 100ml | Amount to 100ml | Amount to 100ml |
Result's (number) | Product of the present invention | Reference product | |||
????1 | ????2 | ????3 | ????4 | ||
Pungent taste beastly | ????0 | ????0 | ????0 | ????0 | ????1 |
Pungent taste | ????0 | ????0 | ????0 | ????0 | ????4 |
Slight pungent taste | ????1 | ????0 | ????0 | ????0 | ????2 |
Slight sweet taste | ????3 | ????1 | ????1 | ????0 | ????0 |
Sweet taste | ????3 | ????6 | ????6 | ????6 | ????0 |
Sweet taste beastly | ????0 | ????0 | ????0 | ????1 | ????0 |
Find out obviously that from table 2 reference product that does not contain glycyrrhizic acid dipotassium has pungent taste and where applicable mouthfeel poor, and glycyrrhizic acid dipotassium content to be every kind of product of the present invention of 0.05 to 1.0w/v% have sweet taste and excellent mouthfeel.Embodiment 2
According to preparing the laryngeal disinfecting, antimicrobial medicine of component such as table 3 respectively with embodiment 1 similar methods.During preparation, with their pH regulator to 2 to 6.They are kept at 60 ℃ of one week and study the influence of pH to available iodine and glycyrrhizic acid dipotassium stability.The results are shown in Figure 1 with what residual rate was represented.
Table 3
Composition | Product of the present invention | |
????5 | ????6 | |
Povidone-iodine | ????0.2g | ????0.2g |
Glycyrrhizic acid dipotassium | ????0.2g | ????0.2g |
Sodium iodide | ????1.0g | ????1.0g |
The 1-menthol | ????0.3g | ????0.3g |
Concentrate glycerol | ????80.0g | ????80.0g |
Ethanol | ????15.0g | ????15.0g |
The pH regulator agent | Hydrochloric acid | Citric acid |
Pure water | Amount to 100ml | Amount to 100ml |
The result of Fig. 1 obviously shows, in the scope of pH3 to 5, and the stability of available iodine variation when pH alcaliotropism direction changes in the disinfecting, antimicrobial medicine of the present invention, and glycyrrhizic acid dipotassium stability variation when pH oxytropism direction changes.Therefore, their stability has conflict.But, be possible when pH obtains enough stability in above-mentioned scope.Embodiment 3
With preparing the laryngeal disinfecting, antimicrobial medicine of component such as table 4, and use the sensory feel test of carrying out the sense of taste with embodiment 1 similar methods with embodiment 1 similar methods.The results are shown in Table 5.
Table 4
Composition | Product of the present invention | |||
????7 | ????8 | ????9 | ????10 | |
Povidone-iodine | ????0.05g | ????0.1g | ????0.7g | ????1.0g |
Glycyrrhizic acid dipotassium | ????0.2g | ????0.2g | ????0.2g | ????0.2g |
Potassium iodide | ????1.0g | ????1.0g | ????1.0g | ????1.0g |
The 1-menthol | ????0.3g | ????0.3g | ????0.3g | ????0.3g |
Concentrate glycerol | ????80.0g | ????80.0g | ????80.0g | ????80.0g |
Ethanol | ????15.0g | ????15.0g | ????15.0g | ????15.0g |
Hydrochloric acid | An amount of * | An amount of * | An amount of * | An amount of * |
Pure water amounts to 100ml and amounts to 100ml total 100ml total 100ml*: with the amount of pH regulator to 4
Table 5
Result's (number) | Product of the present invention | |||
???7 | ???8 | ???9 | ???10 | |
Pungent taste beastly | ???0 | ???0 | ???0 | ????0 |
Pungent taste | ????0 | ????0 | ????0 | ????0 |
Slight pungent taste | ????0 | ????0 | ????0 | ????0 |
Slight sweet taste | ????0 | ????1 | ????0 | ????2 |
Sweet taste | ????7 | ????6 | ????7 | ????5 |
Sweet taste beastly | ????0 | ????0 | ????0 | ????0 |
With obviously finding out in the table 5, every kind of product of the present invention all has sweet taste and has excellent mouthfeel, and they have excellent stability in addition.
The antiseptic and antibiotic agent that the present invention is used for throat has sweet taste, and less stimulation and burning sensation have excellent mouthfeel and excellent stability in use.
Claims (6)
1. a laryngeal disinfecting, antimicrobial compositions wherein contains povidone-iodine and glycyrrhizic acid dipotassium.
2. the described compositions of claim 1 wherein contains 0.05 to 1w/v% povidone-iodine and 0.05 to 1w/v% glycyrrhizic acid dipotassium.
3. claim 1 or 2 described compositionss, its pH is 3 to 5.
4. each described compositions in the claim 1 to 3 wherein also contains solvent.
5. the described compositions of claim 4, wherein solvent is at least a solvent that is selected from water, ethanol, propylene glycol and glycerol.
6. the described compositions of arbitrary claim in the claim 1 to 5 wherein also contains the composition that is selected from cosolvent, correctives, aromatic and anti-inflammatory agent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP109350/95 | 1995-05-08 | ||
JP7109350A JPH08301774A (en) | 1995-05-08 | 1995-05-08 | Throat disinfectant |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1183724A true CN1183724A (en) | 1998-06-03 |
CN1089589C CN1089589C (en) | 2002-08-28 |
Family
ID=14508007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96193782A Expired - Fee Related CN1089589C (en) | 1995-05-08 | 1996-04-26 | Laryngeal bactericidal and antiseptic composition |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPH08301774A (en) |
KR (1) | KR19980703866A (en) |
CN (1) | CN1089589C (en) |
AU (1) | AU5515196A (en) |
TW (1) | TW363890B (en) |
WO (1) | WO1996035434A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102526176A (en) * | 2012-01-21 | 2012-07-04 | 保定冀中药业有限公司 | Oral administration mineral medicine manufactured by liquorice aqueous extracts |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2273493T3 (en) * | 1998-05-27 | 2007-05-01 | Euro-Celtique S.A. | USE OF PREPARATIONS FOR THE APPLICATION OF ANTISEPTIC AGENTS AND / OR AGENTS THAT FAVOR THE HEALING OF WOUNDS TO THE LOWER RESPIRATORY TRACT. |
US6491175B1 (en) | 2000-06-28 | 2002-12-10 | Saad Taha | Single piece closure for a pressurized container |
JP4084329B2 (en) * | 2004-03-31 | 2008-04-30 | 小林製薬株式会社 | Liquid composition and method for producing the same |
JP6320616B1 (en) * | 2017-08-22 | 2018-05-09 | ヴェローチェ・バイオファーマ・エルエルシー | Novel ophthalmic compositions and methods of use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58152808A (en) * | 1982-03-05 | 1983-09-10 | Kiyuushin Seiyaku Kk | Collutorium composition |
JPH06172192A (en) * | 1992-12-10 | 1994-06-21 | Masaya Ootsuka | Aqueous disinfectant for vaginal and intraoral mucosa |
JP4169804B2 (en) * | 1994-06-10 | 2008-10-22 | 小林製薬株式会社 | Iodine preparation with fragrance |
-
1995
- 1995-05-08 JP JP7109350A patent/JPH08301774A/en active Pending
-
1996
- 1996-04-26 WO PCT/JP1996/001175 patent/WO1996035434A1/en not_active Application Discontinuation
- 1996-04-26 CN CN96193782A patent/CN1089589C/en not_active Expired - Fee Related
- 1996-04-26 AU AU55151/96A patent/AU5515196A/en not_active Abandoned
- 1996-04-26 KR KR1019970707266A patent/KR19980703866A/en not_active Application Discontinuation
- 1996-05-03 TW TW085105323A patent/TW363890B/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102526176A (en) * | 2012-01-21 | 2012-07-04 | 保定冀中药业有限公司 | Oral administration mineral medicine manufactured by liquorice aqueous extracts |
CN102526176B (en) * | 2012-01-21 | 2013-10-30 | 保定冀中药业有限公司 | Oral administration mineral medicine manufactured by liquorice aqueous extracts |
Also Published As
Publication number | Publication date |
---|---|
AU5515196A (en) | 1996-11-29 |
JPH08301774A (en) | 1996-11-19 |
TW363890B (en) | 1999-07-11 |
CN1089589C (en) | 2002-08-28 |
WO1996035434A1 (en) | 1996-11-14 |
KR19980703866A (en) | 1998-12-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69938452T2 (en) | Spray-dried insulin microparticles for inhalation | |
EP0789580B1 (en) | Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them | |
EP0304627B1 (en) | Antimicrobial active aromatic compositions | |
EP1993515B1 (en) | Method for solubilizing, dispersing, and stabilizing materials, products manufactured according to said method, and use thereof | |
DE3241097C2 (en) | ||
DE60310377T2 (en) | A LONG-TERM, PARASITO-DESOLDERING PREPARATION CONTAINING A SALICYLANILIDE COMPOUND, A POLYMONIC COMPOUND, AND AT LEAST ONE MORE PARASITO-DESOLDERING COMPOUND | |
DE3346123A1 (en) | PHARMACEUTICAL PREPARATIONS OF SUBSTANCES MEDICAL OR UNSTABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF | |
EP1818041A2 (en) | Pharmaceutical and/or cosmetic composition containing an organosiloxane and a phospholipid | |
EP1255557B1 (en) | Stable, nasally, orally or sublingually applicable pharmaceutical preparation containing desmopressin | |
CN1089589C (en) | Laryngeal bactericidal and antiseptic composition | |
JPH09104625A (en) | Biotin-containing liquid agent for internal use | |
DE60025503T2 (en) | Pharmaceutical compositions containing faropenem sodium and a diamine acetate compound for improving gastrointestinal absorption | |
CN101731204A (en) | Pesticide missible oil preparation | |
DE2944350A1 (en) | CYCLODEXTRIN-CHAMOMILE INCLUSION COMPLEXES, METHOD FOR THE PRODUCTION OF THE COMPLEXES AND THE COMPLEXES CONTAINING THE COMPLEXES | |
DE3348164C2 (en) | ||
DE2610020A1 (en) | PHARMACEUTICAL COMPOSITION | |
EP0349797B1 (en) | Stabilized pharmaceutical composition containing n-acetylcystein | |
DE69727507T2 (en) | THERAPEUTIC AND COSMETIC AGENTS, THEIR USE AND PRODUCTION METHOD | |
DE2455203C2 (en) | ||
EP1150660B1 (en) | Pharmaceutical effervescent formulation containing metamizol | |
EP0922450A1 (en) | Effervescent preparation containing a plant extract | |
DE10238161A1 (en) | Mucosal or topical administration of minerals, e.g. for treating muscle spasms, psoriasis or osteoporosis or promoting wound healing, comprises direct application of mineral solution from ampoule | |
DD203465A5 (en) | METHOD FOR PRODUCING A STABLE, DRY ACETYL SALIZYLIC ACID COMPOSITION | |
DE2627706A1 (en) | SULFONAMIDE / POTENTIATOR SOLUTIONS | |
DE69730596T2 (en) | COMBINED THE ALLOPATHIC AND ITS APPROPRIATE HOMEOPHATIC SUBSTANCES |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |