KR19980038705A - Healthy nutritional composition with constipation and odor - Google Patents
Healthy nutritional composition with constipation and odor Download PDFInfo
- Publication number
- KR19980038705A KR19980038705A KR1019960057623A KR19960057623A KR19980038705A KR 19980038705 A KR19980038705 A KR 19980038705A KR 1019960057623 A KR1019960057623 A KR 1019960057623A KR 19960057623 A KR19960057623 A KR 19960057623A KR 19980038705 A KR19980038705 A KR 19980038705A
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- lots
- constipation
- composition
- aloe
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/10—Drying, dehydrating
Abstract
본 발명은 완하성분을 함유하는 알로에 아보레센스(Aloe arborescens)분말에, 동규자와 삼백초의 유효성분을 알코올을 용매로 하여 추출한 엑기스 또는 그의 건조분말을 첨가하여 주성분으로 하고, 여기에 녹차의 유효성분을 추출한 엑기스 또는 그의 건조분말 및 영양보조성분을 배합하여 이루어지는 변비 개선효과 및 변취 개선효과의 상보적인 작용이 있는 건강 영양 조성물에 관한 것이다.The present invention is added to the aloe arborescens powder containing laxative ingredients, the extract extracted by using copper and 300 seconds of the active ingredient as an alcohol or a dry powder thereof as a main component, the active ingredient of green tea The present invention relates to a health nutrition composition having a complementary effect of constipation improvement effect and malodor improvement effect formed by combining extracted extract or its dry powder and nutritional supplement component.
Description
본 발명은 완하성분을 함유하는 알로에 아보레센스(Aloe arborescens)분말에, 동규자와 삼백초의 유효성분을 알코올을 용매로 하여 추출한 엑기스 또는 그의 건조분말을 첨가하여 주성분으로 하고, 여기에 녹차의 유효성분을 추출한 엑기스 또는 그의 건조분말 및 영양보조성분을 배합하여 이루어지는 변비 개선효과 및 변취 개선효과의 상보적인 작용이 있는 건강 영양 조성물에 관한 것이다.The present invention is added to the aloe arborescens powder containing laxative ingredients, the extract extracted by using copper and 300 seconds of the active ingredient as an alcohol or a dry powder thereof as a main component, the active ingredient of green tea The present invention relates to a health nutrition composition having a complementary effect of constipation improvement effect and malodor improvement effect formed by combining extracted extract or its dry powder and nutritional supplement component.
오늘날 식생활 수준의 향상과 더불어 고지방 식품 및 인스턴트식품 등 고칼로리 식품의 섭취가 늘어난 반면, 섬유질 섭취 및 운동량의 부족으로 인하여 변비와 비만 환자가 날로 증가하고 있어 현대인의 건강관리에 위협적인 문제로 대두되고 있다.Today, high-calorie foods such as high-fat foods and instant foods have increased along with the improvement of dietary standards, while constipation and obesity have increased due to lack of fiber intake and lack of exercise. have.
변비의 정확한 정의는 없으나 대변을 볼 때 힘들어하던가, 횟수가 드물거나 정상이상으로 변이 굳은 경우를 말하며, 대개 하루 대변량이 30g이하의 딱딱한 변이거나 배변횟수가 주 2회 이하인 경우 일단 변비로 진단할 수 있다.There is no exact definition of constipation, but it is difficult to see the stool, or it is rare, or the stool is harder than normal.In general, if the stool is less than 30g per day or the stool frequency is less than twice a week, it can be diagnosed as constipation have.
변비는 예로부터 만병의 근원이라 일컬어지고 있으며, 늘 아랫배가 묵직하고, 식욕이 없으며, 미처 배설하지 못한 독소로 인해 두통이나 여드름 피부발진 등이 나타나기도 하고, 심하면 장폐색인 치질, 대장암까지 발생하기도 한다. 이와 같은 사례는 문화수준이 높은 미국이나 일본 등 외국의 사례에서도 잘 나타나고 있으며, 국내에서도 생활수준의 향상에 따라 직장여성을 비롯하여 사무직 종사자 등 변비로 인하여 고통받는 환자가 날로 증가하고 있다.Constipation has long been said to be the source of all kinds of illnesses, and the stomach is always heavy, lacks appetite, and toxins that have not been excreted can cause headaches or acne skin rashes. do. Such cases are well-represented in foreign countries such as the United States and Japan, which have high cultural standards, and the number of patients suffering from constipation, including working women and office workers, is increasing day by day as the standard of living improves in Korea.
이러한 변비는 수분이나 음식물의 섭취, 특히 섬유질의 섭취가 적은 경우, 운동부족, 정서적으로 불안정한 상태 및 변을 자주 참아버린 경우에 잘 생긴다. 또한 하루종일 앉아서 일하는 사무직 종사자나 운전기사, 다이어트를 한다고 커피 한잔에 빵 한조각을 먹는 젊은 여성이나 운동이 부족하고 스트레스가 누적되면 장관운동이 저하되고, 변의 이동능력이 떨어지기 때문에 변비에 자주 걸린다.Such constipation occurs when water or food intake, especially low intake of fiber, lack of exercise, emotional instability and frequent endurance of stool. In addition, office workers or drivers who sit and work all day, eating a piece of bread in a cup of coffee or diet, lack of exercise and stress accumulate intestinal movements are lowered, the ability to move the stool, constipation is frequently caused.
변비를 치료할 때는, 변비를 일으킬 수 있는 대사 및 내분비 장애나 신경조직 장애, 항문질환 등 그 원인을 알 수 있는 경우에는 그것부터 치료해 주어야 한다. 그러나 뚜렷한 원인을 알 수 없는 소위 기능성 변비 환자에서는 생활습관의 개선과 배변훈련이 우선적으로 필요하다. 특히, 아침식사후 의식적으로 배변을 하는 습관을 길러야 한다. 이러한 배변습관과 더불어 변비치료를 위해서는 식이요법이 필수적이다. 섬유질과 물을 많이 흡수하여 소화관의 운송을 활발하게 해 줄 뿐만 아니라 장내의 유효성분을 흡착하여 대변량을 증가시킴으로써 배변을 쉽게 해주기 때문이다. 이러한 이유로 변비를 개선할 수 있는 기능성 식품 개발에 많은 연구가 있어 왔다.When treating constipation, metabolic and endocrine disorders that can cause constipation, nervous system disorders, anal diseases, etc. If the cause is known, you should treat it first. However, in so-called functional constipation patients with no clear cause, lifestyle improvement and bowel training are needed first. In particular, you should develop a habit of consciously bowel movements after breakfast. In addition to these bowel habits for the treatment of constipation diet is essential. This is because it absorbs a lot of fiber and water to facilitate the transport of the digestive tract, and also facilitates bowel movement by increasing the large variance by absorbing the active ingredients in the intestine. For this reason, much research has been made on the development of functional foods that can improve constipation.
이러한 기능성 식품 개발에 있어서, 연구는 동의보감 등의 한방의서에서 밝히고 있는 변비에 효과적이면서 부작용이 없이 사용할 수 있는 각종 천연 식물들을 중심으로 이루어지고 있다. 이중에서 주목되고 있는 생약재로서 하기 표에 정리하면 다음과 같다.In the development of such functional foods, research has been made on various natural plants that can be used effectively and without side effects for constipation, which are disclosed in Oriental medicine such as Dongbobogam. The herbal medicine that is attracting attention among them is summarized as follows.
또한, 최근 알로에의 알로인 성분이 변비 개선에 효과적이라고 보고됨에 따라 알로에를 주 기재로 하고, 여기에 한방 생약재를 첨가 배합하여 이루어진 기능성 식품들이 소개되고 있다.In addition, as recently reported that the aloe component of aloe is effective in improving constipation, functional foods made by adding and combining herbal medicines based on aloe have been introduced.
구체적인 예로, (1) JP 60-387029에는, 알로에와 인삼을 주성분으로 하고 여기에 꿀을 첨가하여 이루어진 조성물이 개시되어 있으며, 이 조성물은 변비, 항염증, 피부성장촉진, 위하수의 치료에 이용할 수 있다고 기재되어 있고,As a specific example, (1) JP 60-387029 discloses a composition comprising aloe and ginseng as a main ingredient and adding honey to it, which can be used for the treatment of constipation, anti-inflammatory, skin growth, and gastric sewage. It is stated that,
(2) JP 4-248971A에는, 알로에, 삼백초, 당, 유당, 과당, 유산균 등을 첨가하여 배합하는 것을 특징으로 하는 약초성분을 함유하는 발효음료의 조성물이 개시되어 있으며, 또, (3) JP 2-223527호에는, 알로에, 황백나무, 일황련, 당약, 개오동나무, 율무 등의 한방제제인 가정약제로서의 원료식물 건조물의 물추출을 함유하는 완장제 조성물이 개시되어 있다.(2) JP 4-248971A discloses a composition of a fermented beverage containing herbal ingredients characterized by adding and mixing aloe, triticale, sugar, lactose, fructose, lactic acid bacteria and the like, and (3) JP 2-223527 discloses an arming agent composition containing water extraction of a dried plant material as a home medicine, which is a herbal medicine such as aloe, rhododendron, Japanese yellow lotus, medicinal herbs, paulownia, yulmu and the like.
그러나, 이들 문헌에서 알로에와 함께 배합되는 생약재들에 대하여 그의 변비개선 효과는 고서에서 전해지고 있는 것일 뿐, 실험을 통하여 입증되지 않은 것이며, 실제 이들 조성물의 구성이 적절한 것인지, 혹은 변비개선 효과가 없는 생약재를 불필요하게 배합한 것은 아닌지, 혹은 목적하는 효과를 위하여 추출 등의 전처리방법을 적절하게 선택한 것인지에 대한 구체적인 검증없이 사용되어 왔다.However, in these documents, the effects of constipation improvement on herbal medicines combined with aloe are only reported in the old books, and have not been proved through experiments. Has been used without specific verification of whether it is unnecessarily compounded or whether the appropriate pretreatment methods such as extraction are selected for the desired effect.
이에, 본 발명자들은 변비 개선효과를 목적으로알로에를 이용한 기능성 식품 조성물에 배합하여 변비 개선효과에 있어서 상승적 작용을 나타낼 수 있는 생약재들에 대하여 실험, 검증을 통하여 선별하여 최적의 조합을 찾아내었다. 또한 실제 변비 개선효과는 생약재를 구성하고 있는 정유성분들에 의한 것임을 발견하고, 물을 사용하지 않고 알코올을 용매로 하여 유효성분을 추출함으로써 변비 개선효과에 있어서 현저한 상승 효과를 나타냄을 발견하고 본 발명을 완성하게 되었다. 또,알로에와 이들 생약재의 조합에, 녹차의 유효성분을 추출하여 배합함으로써 변비 개선효과와 변취 개선효과를 동시에 제공할 수 있는 건강 영양 조성물을 완성하게 되었다.Therefore, the present inventors have found the optimal combination by selecting through the experiment, verification for herbal medicines that can exhibit a synergistic effect in the improvement of constipation by combining in a functional food composition using aloe for the purpose of improving constipation. In addition, the actual constipation improvement effect is found to be due to the essential oil components constituting the herbal medicine, extracts the active ingredient using alcohol as a solvent without using water to find a significant synergistic effect in the constipation improvement effect and the present invention It was completed. In addition, by extracting and blending the active ingredient of green tea in the combination of aloe and these herbal medicines, a healthy nutritional composition capable of simultaneously providing a constipation improvement effect and an odor improvement effect has been completed.
따라서, 본 발명의 목적은, 알로에를 이용한 기능성 건강 조성물에 있어서, 알로에 아보레센스 분말에 배합하여 변비 개선효과에 있어서 상승적 작용을 나타낼 수 있는 생약재들의 최적의 조합을 제공하는 것이다.Accordingly, it is an object of the present invention to provide an optimal combination of herbal medicines in a functional health composition using aloe, which can be combined with aloe aboresense powder and exhibit synergistic effects in constipation improvement.
본 발명에 의하면 상기한 목적은 알로에 아보레센스 분말에, 동규자와 삼백초의 유효성분을 알코올을 용매로 하여 추출한 엑기스 또는 그의 건조분말을 첨가하여 주성분으로 하여, 여기에 녹차의 유효성분을 추출한 엑기스 또는 그의 건조분말을 혼합하고, 영양보조성분을 배합하여 이루어지는 건강 영양 조성물에 의해 달성되며, 본 발명에 따른 조성물은 변비 및 변취 개선에 탁월한 효과를 갖는다.According to the present invention, the above object is added to aloe aboresense powder, an extract containing copper and a 300 sec active ingredient as an alcohol or a dry powder thereof, as a main ingredient, and the extract of the active ingredient of green tea or its extract It is achieved by a healthy nutritional composition consisting of mixing dry powder and blending nutritional supplements, the composition according to the invention has an excellent effect on improving constipation and deodorant.
본 발명에 따른 건강 영양 조성물은 변비 개선효과를 제공할 목적으로 알로에 아보레센스 분말에 특정한 생약재, 즉 삼백초와 동규자의 유효성분을 추출하여 배합하여 이루어지는, 알로에의 변비 개선효과에 있어서 상승적 효과를 제공할 수 있는 최적의 생약재의 조합에 있으며, 삼백초와 동규자의 변비개선 작용을 갖는 유효성분을 추출함에 있어서 물이 아닌 알코올을 추출용매로 사용하는 것에 특징이 있다.The health nutrition composition according to the present invention is provided by extracting and blending a specific herbal medicine, that is, three hundred s. In the best combination of herbal medicines, it is characterized by using alcohol as the extraction solvent in extracting the active ingredient having an effect of improving constipation of 300 seconds and Donggyu.
이하, 본 발명에 따른 변비 및 변취 개선효과가 있는 조성물에 대하여 그의 구성 및 작용효과를 중심으로 보다 구체적으로 설명한다.Hereinafter, the composition with the constipation and odor improvement effect according to the present invention will be described in more detail with a focus on its configuration and effect.
본 발명의 조성물에서 변비 개선효과의 상승적 작용을 목적으로 배합되는 생약재인 삼백초와 동규자는 후술하는 일련의 동물 실험에 의해 선정된 것이며, 가열순환식 추출탱크에서 50~70%의 알코올을 생약재 중량의 약 10배 양으로 첨가하여 75~85℃에서 약 4시간씩 3회 추출한 다음, 약 149㎛ 크기의 여과포로 여과한 후, 여액을 40~70㎝Hg의 감압으로 농축하여 고형분 50~70%의 생약재 엑기스를 제조하거나 또는 이를 건조시켜 분말화한 것이다.Herbal medicine, 300 seconds and Donggyuja, which are formulated for the synergistic effect of the constipation improving effect in the composition of the present invention was selected by a series of animal experiments described below, 50-70% alcohol in the heating circulation extraction tank Add about 10 times the amount and extract about 3 times at 75 ~ 85 ℃ three times, and then filtered with a filter cloth of about 149㎛ size, and the filtrate was concentrated under reduced pressure of 40 ~ 70cmHg of solid content of 50 ~ 70% The herbal extracts are prepared or dried and powdered.
또한, 본 발명의 조성물은 변취 개선효과를 제공할 목적으로 녹차 추출물의 엑기스 또는 그의 건조분말을 함유하는 것을 특징으로 한다.In addition, the composition of the present invention is characterized in that it contains an extract of a green tea extract or its dry powder for the purpose of providing a odor improvement effect.
최근 악취의 주요원인이 유화수소(-SH)나 아민(-NH)류임이 밝혀짐에 따라, -SH기, -NH기와 결합하여 착화합물을 형성하는 폴리페놀이나 플라보노이드류, -SH기, -NH기와 중화반응을 하는 아미노산류, 악취물질을 흡수, 흡착 용해작용을 갖는 당류 등이 소취제로서 주목받고 있다. 녹차는 소취작용을 갖는 이들 성분들을 모두 함유하고 있으며, 특히 이중 폴리페놀이나 플라보노이드류를 다량 함유하고 있어, 녹차의 유효성분을 추출하여 얻은 엑기스나 그의 건조분말은 이미 소취제로서 널리 알려져 있으며, 각종 치약조성물이나 구강용 조성물을 구성하고 있다.Recently, the main causes of malodor are hydrogen emulsion (-SH) or amines (-NH), polyphenols and flavonoids that form complexes by combining with -SH and -NH groups, -SH and -NH Amino acids that neutralize the group and sugars that absorb or smell odorous substances have been attracting attention as deodorants. Green tea contains all of these ingredients with deodorant action. Especially, it contains a large amount of polyphenols and flavonoids, and the extract obtained by extracting the active ingredient of green tea and its dry powder are already widely known as deodorants, and various toothpastes. The composition and the composition for oral cavity are comprised.
※ 악취원 : 1%의 암모니아 0.05㎖※ Bad smell source: 0.05ml of 1% ammonia
실험방법 : 검지관법 사용Experimental Method: Using the Detection Tube Method
탄닌 함량 60%를 기준으로 하여 실시Based on tannin content of 60%
단위 : ppmUnit: ppm
( ) : 소취율(): Deodorization rate
본 발명에 따른 조성물은, 변비개선 효과를 목적으로 알로에 아보레센스 분말을 조성물 총 중량의 50중량% 이상의 양으로 함유하며, 변비개선에 있어서 상승적 작용과 변취개선 효과를 목적으로 삼백초 엑기스와 동규자 엑기스 및 녹차 엑기스 또는 이들의 건조분말을 합한 함량으로 10~40중량%의 양으로 함유한다. 또한 여기에 각종 영양보조 성분을 배합할 수 있는데, 예를 들면, 니코틴산아미드, 파인화이바, 이소말토올리고당, 클로렐라, 비타민 B1, B2, B6, B5, B12, 비타민E 초산에스테르 등을 배합할 수 있으며, 이들 영양보조 성분은 10~30중량%의 양으로 배합한다.The composition according to the present invention contains aloe aboressen powder in an amount of 50% by weight or more of the total weight of the composition for the purpose of constipation improvement effect, 300 seconds extract and Donggyuja extract for synergistic action and odor improvement effect in constipation improvement and Green tea extract or dry powder thereof is added in an amount of 10 to 40% by weight. Various nutritional supplements can also be formulated here, for example, nicotinic acid amide, pine bar, isomaltoligosaccharide, chlorella, vitamin B 1 , B 2 , B 6 , B 5 , B 12 , vitamin E acetate ester, and the like. It can be blended, these nutritional supplements are blended in an amount of 10 to 30% by weight.
또한, 본 발명의 조성물은 그 제형에 있어서 특별히 한정되지 않으며, 구체적인 예로는 정제 또는 과립, 분말형태로 제형화될 수 있다.In addition, the composition of the present invention is not particularly limited in the formulation, specific examples may be formulated in the form of tablets, granules, powders.
이하, 변비개선 및 변취 개선에 있어서 본 발명의 조성물의 탁월한 효과에 대하여 각종 동물실험을 근거로 하여 설명한다. 그러나, 본 발명이 여기에 한정되는 것은 아니다.Hereinafter, the excellent effect of the composition of this invention in improving constipation and improving odor is demonstrated based on various animal experiments. However, the present invention is not limited thereto.
[시험예 1][Test Example 1]
변비의 검사는 배변횟수, 대변의 딱딱한 정도, 배변후 잔변감이 있는지, 배변시에 출혈이나 통증에 대하여 자세하게 조사하는 것이 중요하다.It is important to examine constipation in detail for the number of bowel movements, the stiffness of the stool, the presence of residual stool after defecation, and bleeding or pain during defecation.
변비에 효과가 있다고 보고되고 있는 알로에와 각종 생약재 엑기스의 혼합물에 대하여 변비 개선효과를 비교, 평가하기 위하여, 변비를 유빌시킨 랫트의 시일 경과에 따른 대변량과 대변 수분함량을 측정하였다.In order to compare and evaluate the effects of constipation on the mixture of aloe and various herbal extracts, which are reported to be effective in constipation, fecal and fecal water contents of rats with constipation over time were measured.
실험은 로페린(한국얀센, 지사제, 대장운동억제제)을 0.14㎎/250g b.w.로 1회/1일 복강투여로 변비를 유발시킨 랫트를 19로트로 다음과 같이 분획하여 실시하였다.The experiment was performed by dividing loperin (Jansen Korea, antimicrobial agent, colon colon inhibitor) into 0.14 mg / 250 g b.w.
※ 알로에 엑기스는 공지의 기술 제조한 것이며, 자사 원료를 사용하였다.※ Aloe extract was manufactured by a well-known technique, and its raw material was used.
대조군을 제외한 상기 18개 로트 실험군 각각의 시료를 식염수에 용해시켜 사용하였으며, 4주동안 체중 사료섭취량, 물섭취량, 대변의 수분함량을 매일 같은 시각(오전 8시 30분)에 측정하였다. 각실험군은 로트당 7마리를 사용하였으며, 그룹으로 나누어 메타볼릭케이지(metabolic cage)에 키우면서 변비개선효과를 검토하였다.Samples of each of the 18 lot experimental groups, except for the control group, were dissolved and used in saline, and body weight intake, water intake, and water content of feces were measured at the same time every day (8:30 am) for 4 weeks. Each experiment group used 7 animals per lot, and divided into groups to raise the metabolic cage to examine the effect of constipation improvement.
본 실험의 결과는 순화종료시점(3일), 변비유발 종료시점(16일)을 기준 100으로 하여, 각 시점에서 동물 개개의 값을 상대값으로 계산해 변비개선효과를 검토하였다.The results of this experiment were 100 based on the end of purifying (day 3) and the end of constipation induction (16 days).
상기 표 4와 표 5로부터 알 수 있는 바와 같이, 변비유발 랫트실험을 통하여 대변량과 대변의 수분함량을 검토한 결과, 변비개선효과가 공지기술에 의한알로에엑기스 분말과 삼백초 엑기스와 동규자 엑기스를 혼합한 투여군이 가장 좋은 결과를 나타내었다.As can be seen from Table 4 and Table 5, as a result of examining the water content of feces and feces through the constipation-induced rat experiments, a constipation improvement effect is a mixture of aloe extract powder, three hundred seconds extract and copper ruler extract according to the known technology One group showed the best results.
[시험예 2][Test Example 2]
시험예 1의 결과를 기초로 하여,알로에와 동규자와 삼백초엑기스의 추출 용매에 따른 추출수율 및 변비개선효과의 상승 유무를 검토하였다.Based on the results of Test Example 1, the extraction yield and the improvement of constipation improvement effect according to the extraction solvent of aloe and copper gyuja and three hundred sec extract were examined.
(2-1) 용매별 추출 엑기스의 수율 조사(2-1) Yield investigation of extraction extract for each solvent
추출물 일정량을 취하여 적외선 수분기(sartorius)로 용매별 수율을 조사하여 표 5에 그 결과를 나타내었다.Taking a certain amount of the extract by infrared solvent (sartorius) to investigate the yield by solvent and the results are shown in Table 5.
(2-2) 변비 개선효과(2-2) Constipation Improvement
각 실험군은 로트당 7마리를 사용하였으며, 순화종료시점(3일)과 변비유발 종료시점(16일)을 기준으로하여 매일 일정한 시각(아침 8시 30분에)에 각 시점에서 동물개개의 값을 기준으로하여 상대값으로 계산해 변비개선효과의 통계적 유의차를 검토하였다.Each experimental group used 7 animals per lot, and each animal at each time at a certain time (at 8:30 in the morning) on the basis of the end of purifying (3 days) and the end of constipation (16 days) Based on the relative value, the statistical significance of the effect of constipation improvement was examined.
※ 1~3로트 실험군의 복강 투여 물질의 조성은, 사람 1일 섭취량의 10배 농도의 알로에 : 생약재 엑기스(동규자(5)+삼백초(5)) = 1 : 1의 조성물이다.* The composition of the intraperitoneal administration substance of 1 to 3 lots of experimental groups is a composition of aloe: herbal extract ((Kyugyuja (5) + 300 seconds (5)) = 1: 1) of 10 times the concentration of human daily intake.
변비의 유발은 시험예 1에서와 동일하게, 로페린(한국얀센, 지사제, 대장운동억제제)을 0.14㎎/250g b.w.로 1회/1일 복강투여하였으며, 대변량과 대변중의 수분함량을 측정하여 변비개선의 상승유무를 검토하였다.Induction of constipation was performed intraperitoneally with 0.14 mg / 250 g bw of loperin (Jansen Korea, antimicrobial agent, colorectal inhibitor) as per Test Example 1, and measured stool and water content in feces. This study examined the improvement of constipation.
상기 표 6 내지 표 8의 결과로부터, 50% 알코올로 추출하는 경우 추출수율도 우수할 뿐만 아니라 물추출에 비해 변비개선효과에 있어서도 더 우수함을 알 수 있다.From the results of Tables 6 to 8, when extracted with 50% alcohol, it can be seen that not only the extraction yield is excellent but also the constipation improvement effect compared to water extraction.
[시험예 3][Test Example 3]
상기 시험예 1과 2의 결과를 기초로 하여, 50%의 알코올로 추출한 동규자와 삼백초 엑기스의 배합비율에 따른 변비개선효과의 상승유무를 검토하였다.On the basis of the results of Test Examples 1 and 2, the presence or absence of the improvement of constipation improvement effect according to the blending ratio of copper gyugi and 300 seconds extract extracted with 50% alcohol.
각 실험군은 로트당 7마리를 사용하였으며, 순화종료시점(3일)과 변비유발 종료시점(16일)을 기준으로하여 매일 일정한 시각(아침 8시 30분에)에 각 시점에서 동물개개의 값을 기준으로하여 상대값으로 계산해 변비개선효과의 통계적 유의차를 검토하였다.Each experimental group used 7 animals per lot, and each animal at each time at a certain time (at 8:30 in the morning) on the basis of the end of purifying (3 days) and the end of constipation (16 days) Based on the relative value, the statistical significance of the effect of constipation improvement was examined.
변비의 유발은 시험예 1에서와 동일하게, 로페린(한국얀센, 지사제, 대장운동억제제)을 0.14㎎/250g b.w.로 1회/1일 복강투여하였으며, 대변량과 대변중의 수분함량을 측정하여 변비개선의 상승유무를 검토하였다.Induction of constipation was performed intraperitoneally with 0.14 mg / 250 g bw of loperin (Jansen Korea, antimicrobial agent, colorectal inhibitor) as per Test Example 1, and measured stool and water content in feces. This study examined the improvement of constipation.
상기 표 9와 표 10의 결과로부터, 삼백초와 동규자 엑기스는 그 배합비율에 있어서 특별히 제한됨이 없음을 알 수 있다.From the results of Table 9 and Table 10, it can be seen that the three hundred seconds and copper sperm extract is not particularly limited in the blending ratio.
이상의 시험예 1 내지 3의 실험결과에 의거하여 변비개선효과가 있는알로에엑기스 분말과 50~70%의 알코올을 추출용매로 하여 추출한 삼백초와 동규자 엑기스 또는 그의 건조분말을 혼합하여 주원료로 하고, 여기에 소취작용이 확인된 녹차엑기스 또는 그의 건조분말 및 각종 영양 보조성분들을 배합하여 변비개선효과 및 변취개선효과를 갖는 건강 영양조성물을 제조한다.Based on the test results of Test Examples 1 to 3 above, aloe extract powder having a constipation improvement effect and 50-70% alcohol were extracted as an extract solvent, and then mixed with 300 sec. The green tea extract or its dried powder and various nutritional supplements having a deodorizing effect are blended to prepare a health nutrition composition having an effect of improving constipation and improving odor.
[참고예][Reference Example]
알로에 아보레센스 분말은 자사 원료를 사용하였다.Aloe Aborescens powder uses its own raw material.
삼백초 1㎏을 가열순환식 추출탱크에 넣고 50~70%의 알코올 10㎏을 가하여 75~85℃에서 4시간씩 3회 추출한 다음, 149㎛크기의 여과포로 여과한 후, 여과한 용액을 40~70㎝Hg의 감압으로 농축하여 고형분 60%의 삼백초 엑기스 300g을 얻었다.Three kilograms of 1 kg were put into a heating circulation extraction tank, and 10 kg of 50-70% alcohol was added and extracted three times at 75-85 ° C. for 4 hours, and then filtered through a 149 μm filter cloth. Concentration under reduced pressure of 70 cmHg afforded 300 g of a 300 sec extract having a solid content of 60%.
동규자도 상기와 동일한 방법으로 추출하여 고형분 56%의 동규자 엑기스를 얻었다.Donggukja was also extracted in the same manner as above to obtain a 56% solids copper extract.
[실시예 1]Example 1
알로에 아보레센스 분말 1㎏과 참고예에서와 같은 방법으로 추출한 삼백초 엑기스(고형분 60%) 340g 및 동규자 엑기스(고형분 56%) 140g과, 합한 양이 조성물의 5~10%가 되도록 50%의 알코올, 올리고당 90g 및 영양 보조성분(비타민 B2, B5, B6, B12, 비타민 E 초산에스테르 및 니코틴산아미드)을 고속회전혼합기에서 혼합시켰다. 여기에 파인화이바 130g, 녹차추출물 100g, 결정셀룰로오스 130g을 가하여 혼합하고, 멸균정제수 10%을 다시 혼합하여 직경 1~2㎜의 과립상태로 성형시켰다. 성형된 과립을 40~50℃의 진공건조기에서 건조시킨 후, 12~14메쉬의 체에 통과시켜 균일한 과립을 제조하였다.1 kg of aloe aborescens powder and 340 g of the 300 sec extract (60% solids) and 140 g of Donggyuja extract (56% solids) extracted in the same manner as in the reference example, 50% alcohol so that the combined amount is 5-10% of the composition, 90 g of oligosaccharide and nutritional supplements (vitamins B 2 , B 5 , B 6 , B 12 , vitamin E acetate ester and nicotinamide) were mixed in a high speed rotary mixer. 130 g of fine fiber, 100 g of green tea extract, and 130 g of crystalline cellulose were added thereto, and 10% of sterile purified water was mixed again to form granules having a diameter of 1 to 2 mm. The molded granules were dried in a vacuum dryer at 40-50 ° C., and then passed through a 12-14 mesh sieve to prepare uniform granules.
또한, 위의 공정으로 제조한 과립을 적당량씩 압출성형하여 정제 또는 분말을 만들거나, 경질캡슐에 충전시켜 경질캡슐로 제조할 수도 있다.In addition, the granules prepared by the above process may be extruded by appropriate amounts to make tablets or powders, or may be prepared into hard capsules by filling in hard capsules.
[실시예 2]Example 2
알로에 아보레센스 분말 1㎏과 참고예에서와 같은 방법으로 추출한 삼백초 엑기스(고형분 60%) 340g 및 동규자 엑기스(고형분 56%) 140g과, 합한 양이 조성물의 5~10%가 되도록 50%의 알코올, 올리고당 100g 및 영양 보조성분(비타민 B2, B5, B6, B12, 비타민 E 초산에스테르 및 니코틴산아미드)을 고속회전혼합기에서 혼합시켰다. 여기에 파인화이바 100g, 녹차추출물 100g, 클로렐라 50g, 결정셀룰로오스 120g을 가하여 혼합하고, 멸균정제수 10%을 다시 혼합하여 직경 1~2㎜의 과립상태로 성형시켰다. 성형된 과립을 40~50℃의 진공건조기에서 건조시킨 후, 12~14메쉬의 체에 통과시켜 균일한 과립을 제조하였다.1 kg of aloe aborescens powder and 340 g of the 300 sec extract (60% solids) and 140 g of Donggyuja extract (56% solids) extracted in the same manner as in the reference example, 50% alcohol so that the combined amount is 5-10% of the composition, 100 g of oligosaccharide and nutritional supplements (vitamin B 2 , B 5 , B 6 , B 12 , vitamin E acetate ester and nicotinamide) were mixed in a high speed rotary mixer. To this, 100 g of fine fiber, 100 g of green tea extract, 50 g of chlorella, and 120 g of crystalline cellulose were added and mixed, and 10% of sterile purified water was mixed again to form a granule having a diameter of 1 to 2 mm. The molded granules were dried in a vacuum dryer at 40-50 ° C., and then passed through a 12-14 mesh sieve to prepare uniform granules.
또한, 위의 공정으로 제조한 과립을 적당량씩 압출성형하여 정제 또는 분말을 만들거나, 경질캡슐에 충전시켜 경질캡슐로 제조할 수도 있다.In addition, the granules prepared by the above process may be extruded by appropriate amounts to make tablets or powders, or may be prepared into hard capsules by filling in hard capsules.
[실시예 3]Example 3
알로에 아보레센스 분말 1.3㎏과 참고예에서와 같은 방법으로 추출한 삼백초 엑기스(고형분 60%) 200g 및 동규자 엑기스(고형분 56%) 140g과, 합한 양이 조성물의 5~10%가 되도록 50%의 알코올, 올리고당 60g 및 영양 보조성분(비타민 B2, B5, B6, B12, 비타민 E 초산에스테르 및 니코틴산아미드)을 고속회전혼합기에서 혼합시켰다. 여기에 파인화이바 50g, 녹차추출물 100g, 결정셀룰로오스 100g을 가하여 혼합하고, 멸균정제수 10%을 다시 혼합하여 직경 1~2㎜의 과립상태로 성형시켰다. 성형된 과립을 40~50℃의 진공건조기에서 건조시킨 후, 12~14메쉬의 체에 통과시켜 균일한 과립을 제조하였다.1.3 kg of Aloe Aboressen powder and 200 g of 300 sec extract (60% solids) and 140 g of Donggyuja extract (56% solids) extracted in the same manner as in the reference example, 50% alcohol so that the combined amount is 5-10% of the composition, 60 g oligosaccharides and nutritional supplements (vitamins B 2 , B 5 , B 6 , B 12 , vitamin E acetate ester and nicotinamide) were mixed in a high speed rotary mixer. 50 g of fine fiber, 100 g of green tea extract, and 100 g of crystalline cellulose were added thereto, and 10% of sterile purified water was mixed again to form granules having a diameter of 1 to 2 mm. The molded granules were dried in a vacuum dryer at 40-50 ° C., and then passed through a 12-14 mesh sieve to prepare uniform granules.
또한, 위의 공정으로 제조한 과립을 적당량씩 압출성형하여 정제 또는 분말을 만들거나, 경질캡슐에 충전시켜 경질캡슐로 제조할 수도 있다.In addition, the granules prepared by the above process may be extruded by appropriate amounts to make tablets or powders, or may be prepared into hard capsules by filling in hard capsules.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100437933B1 (en) * | 2001-12-06 | 2004-07-02 | 박동기 | The health-assisting food having improvement effects of constipation and intestines activity and its compositions |
KR100506824B1 (en) * | 2002-12-12 | 2005-08-11 | 주식회사 케이티앤지 | Crude Drug Compositions for treating or preventing intestinal disease and constipation |
KR100895091B1 (en) * | 2007-04-30 | 2009-04-28 | 주식회사 바이오리쏘스 | MULBERY COMPOSITION AND MULBERY COMPOSITION ERMENTED BY STARTER OF Lactobacillus sp. |
CN107683923A (en) * | 2017-10-13 | 2018-02-13 | 福建生物工程职业技术学院 | One kind relaxes bowel plant tea bag and preparation method thereof |
KR20220144005A (en) | 2021-04-16 | 2022-10-26 | 주식회사 케이제이엠바이오 | Method for producing fermented tindall aloe lactic acid bacteria powder and immunity enhancing composition containing the same |
Families Citing this family (3)
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KR100370814B1 (en) * | 2000-01-11 | 2003-02-05 | 충청북도 농업기술원 | A tea granules made from the extract of Saururus Chinensis Bail and the manufacturing method thereof |
KR20010073975A (en) * | 2000-10-02 | 2001-08-04 | 이창환 | a manufacturing method of the tea by using the cascara sagrada |
KR20220167129A (en) | 2021-06-11 | 2022-12-20 | 주식회사 비욘드푸드 | Health assistance food composition showing the effect of promoting bowel movement and diet and intake method of the composition |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100437933B1 (en) * | 2001-12-06 | 2004-07-02 | 박동기 | The health-assisting food having improvement effects of constipation and intestines activity and its compositions |
KR100506824B1 (en) * | 2002-12-12 | 2005-08-11 | 주식회사 케이티앤지 | Crude Drug Compositions for treating or preventing intestinal disease and constipation |
KR100895091B1 (en) * | 2007-04-30 | 2009-04-28 | 주식회사 바이오리쏘스 | MULBERY COMPOSITION AND MULBERY COMPOSITION ERMENTED BY STARTER OF Lactobacillus sp. |
CN107683923A (en) * | 2017-10-13 | 2018-02-13 | 福建生物工程职业技术学院 | One kind relaxes bowel plant tea bag and preparation method thereof |
KR20220144005A (en) | 2021-04-16 | 2022-10-26 | 주식회사 케이제이엠바이오 | Method for producing fermented tindall aloe lactic acid bacteria powder and immunity enhancing composition containing the same |
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