KR102950624B1 - 원형 폴리리보뉴클레오티드를 포함하는 조성물 및 이의 용도 - Google Patents

원형 폴리리보뉴클레오티드를 포함하는 조성물 및 이의 용도

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Publication number
KR102950624B1
KR102950624B1 KR1020217005234A KR20217005234A KR102950624B1 KR 102950624 B1 KR102950624 B1 KR 102950624B1 KR 1020217005234 A KR1020217005234 A KR 1020217005234A KR 20217005234 A KR20217005234 A KR 20217005234A KR 102950624 B1 KR102950624 B1 KR 102950624B1
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target
circular polyribonucleotide
rna
sequence
circular
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KR20210039401A (ko
Inventor
아박 카베지안
니콜라스 맥카트니 플러기스
뵈르 알렉산드라 소피 드
모라그 헬렌 스튜어트
캐서린 시프엔테스-로자스
기 영 백
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플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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KR1020217005234A 2018-07-24 2019-07-24 원형 폴리리보뉴클레오티드를 포함하는 조성물 및 이의 용도 Active KR102950624B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862702714P 2018-07-24 2018-07-24
US62/702,714 2018-07-24
US201962823569P 2019-03-25 2019-03-25
US62/823,569 2019-03-25
US201962863670P 2019-06-19 2019-06-19
US62/863,670 2019-06-19
PCT/US2019/043272 WO2020023655A1 (en) 2018-07-24 2019-07-24 Compositions comprising circular polyribonucleotides and uses thereof

Publications (2)

Publication Number Publication Date
KR20210039401A KR20210039401A (ko) 2021-04-09
KR102950624B1 true KR102950624B1 (ko) 2026-04-10

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Country Link
US (1) US20210292761A1 (https=)
EP (1) EP3827084A4 (https=)
JP (2) JP2021531022A (https=)
KR (1) KR102950624B1 (https=)
CN (1) CN112567038A (https=)
AU (2) AU2019312269A1 (https=)
BR (1) BR112021001343A2 (https=)
CA (1) CA3107683A1 (https=)
IL (1) IL280354A (https=)
MX (1) MX2021000965A (https=)
SG (1) SG11202100750XA (https=)
WO (1) WO2020023655A1 (https=)

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CN111819185A (zh) 2017-12-15 2020-10-23 旗舰创业创新第六有限责任公司 包含环状多核糖核苷酸的组合物及其用途
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US20220288176A1 (en) * 2019-08-28 2022-09-15 The Board Of Trustees Of The Leland Stanford Junior University Circular rna modification and methods of use
AU2020395113A1 (en) 2019-12-02 2022-06-09 Shape Therapeutics Inc. Therapeutic editing
CN115361954A (zh) 2020-01-29 2022-11-18 旗舰创业创新第六有限责任公司 用于翻译的组合物及其使用方法
CN111500681A (zh) * 2020-03-20 2020-08-07 青岛大学 用于检测piRNA与mRNA结合的可视化方法及其应用
US20230203192A1 (en) * 2020-05-20 2023-06-29 Flagship Pioneering, Inc. Compositions and methods for producing human polyclonal antibodies
KR20230028375A (ko) 2020-06-25 2023-02-28 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법
AU2021300378A1 (en) * 2020-07-01 2023-01-19 Elevatebio Technologies, Inc. Compositions and methods for cellular reprogramming using circular RNA
CN113249811B (zh) * 2021-05-13 2022-11-08 太原理工大学 一种中空纳米纤维内部固定化生物酶的制备方法
US20240240218A1 (en) 2021-05-18 2024-07-18 Flagship Pioneering Innovations Vi, Llc Methods of enriching for circular polyribonucleotides
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AU2022285744A1 (en) * 2021-06-02 2023-12-14 Beam Therapeutics Inc. Circular guide rnas for crispr/cas editing systems
CA3219570A1 (en) * 2021-06-25 2022-12-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for improved protein translation from recombinant circular rnas
CN113264842B (zh) 2021-07-21 2022-03-01 苏州科锐迈德生物医药科技有限公司 一种脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
US20250002898A1 (en) 2021-07-27 2025-01-02 Flagship Pioneering Innovations Vi, Llc Devices, systems and methods for processing
CN114591986A (zh) * 2021-07-29 2022-06-07 苏州科锐迈德生物医药科技有限公司 环状rna分子及其在目标蛋白的靶向降解中的应用
MX2024003262A (es) 2021-09-17 2024-06-19 Flagship Pioneering Innovations Vi Llc Composiciones y metodos para producir poliribonucleotidos circulares.
CN116103284B (zh) * 2021-11-09 2025-09-23 中国科学院天津工业生物技术研究所 环形gRNA及其相关生物材料与应用
KR20240118174A (ko) 2021-12-17 2024-08-02 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 변성 조건 하에서의 원형 rna의 풍부화를 위한 방법
CN121057577A (zh) 2023-01-27 2025-12-02 赛欧生物医药股份有限公司 经修饰的脂质组合物及其用途
WO2025127854A1 (ko) * 2023-12-14 2025-06-19 한국과학기술원 Circular rna를 이용한 표적 mrna 발현 저해

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SG11202100750XA (en) 2021-02-25
WO2020023655A1 (en) 2020-01-30
US20210292761A1 (en) 2021-09-23
MX2021000965A (es) 2021-06-15
EP3827084A1 (en) 2021-06-02
KR20210039401A (ko) 2021-04-09
JP2021531022A (ja) 2021-11-18
IL280354A (en) 2021-03-25
AU2026201251A1 (en) 2026-03-12
EP3827084A4 (en) 2023-03-15
BR112021001343A2 (pt) 2021-05-04
AU2019312269A1 (en) 2021-03-04
CA3107683A1 (en) 2020-01-30
CN112567038A (zh) 2021-03-26
JP2024169484A (ja) 2024-12-05

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