KR102928755B1 - 중독 치료 방법 - Google Patents

중독 치료 방법

Info

Publication number
KR102928755B1
KR102928755B1 KR1020217026674A KR20217026674A KR102928755B1 KR 102928755 B1 KR102928755 B1 KR 102928755B1 KR 1020217026674 A KR1020217026674 A KR 1020217026674A KR 20217026674 A KR20217026674 A KR 20217026674A KR 102928755 B1 KR102928755 B1 KR 102928755B1
Authority
KR
South Korea
Prior art keywords
compound
pharmaceutical composition
formula
alkyl
opioid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217026674A
Other languages
English (en)
Korean (ko)
Other versions
KR20210118889A (ko
Inventor
펑 리
웨이 야오
로버트 데이비스
샤론 메이츠
킴벌리 배노버
그렛첸 스나이더
Original Assignee
인트라-셀룰라 써래피스, 인코퍼레이티드.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인트라-셀룰라 써래피스, 인코퍼레이티드. filed Critical 인트라-셀룰라 써래피스, 인코퍼레이티드.
Publication of KR20210118889A publication Critical patent/KR20210118889A/ko
Application granted granted Critical
Publication of KR102928755B1 publication Critical patent/KR102928755B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Addiction (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217026674A 2019-01-23 2020-01-23 중독 치료 방법 Active KR102928755B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962795899P 2019-01-23 2019-01-23
US62/795,899 2019-01-23
PCT/US2020/014818 WO2020154519A2 (en) 2019-01-23 2020-01-23 Methods of treating addiction

Publications (2)

Publication Number Publication Date
KR20210118889A KR20210118889A (ko) 2021-10-01
KR102928755B1 true KR102928755B1 (ko) 2026-02-19

Family

ID=71735540

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217026674A Active KR102928755B1 (ko) 2019-01-23 2020-01-23 중독 치료 방법

Country Status (10)

Country Link
US (1) US20220088014A1 (https=)
EP (1) EP3914235A4 (https=)
JP (1) JP7555343B2 (https=)
KR (1) KR102928755B1 (https=)
CN (2) CN118105390A (https=)
AU (1) AU2020212019B2 (https=)
CA (1) CA3125777A1 (https=)
IL (1) IL284797A (https=)
MX (2) MX2021008717A (https=)
WO (1) WO2020154519A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
JP7520013B2 (ja) 2018-12-17 2024-07-22 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ－カルボリンの合成
IL315005B2 (en) 2018-12-17 2026-04-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
JP7649743B2 (ja) 2018-12-21 2025-03-21 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
MX2024004725A (es) * 2021-10-19 2024-05-10 Intra Cellular Therapies Inc Metodos novedosos.
CN116210637A (zh) * 2021-12-06 2023-06-06 中国科学院深圳先进技术研究院 一种成瘾药物戒断后复吸相关调控基因及其筛选方法
WO2024145659A1 (en) * 2022-12-30 2024-07-04 Intra-Cellular Therapies, Inc. Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor
WO2025257090A1 (en) 2024-06-10 2025-12-18 Interquim, S.A. Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues
CN119912455B (zh) * 2025-01-22 2025-09-23 成都臻拓医药科技有限公司 一种卢美哌隆中间体化合物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE277048T1 (de) * 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte hetercyclisch kondensierte gamma carboline
PL3838274T3 (pl) * 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
WO2018126140A1 (en) * 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
EP3562484B1 (en) * 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
EP3658144B1 (en) * 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
WO2019023062A1 (en) * 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
EP3801527B1 (en) * 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Fused gamma-carbolines for acute treatment of anxiety or depression
JP7649743B2 (ja) * 2018-12-21 2025-03-21 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物

Also Published As

Publication number Publication date
CN113329742A (zh) 2021-08-31
AU2020212019B2 (en) 2025-04-17
EP3914235A2 (en) 2021-12-01
CA3125777A1 (en) 2020-07-30
WO2020154519A3 (en) 2020-09-17
EP3914235A4 (en) 2022-09-07
CN118105390A (zh) 2024-05-31
JP7555343B2 (ja) 2024-09-24
WO2020154519A2 (en) 2020-07-30
US20220088014A1 (en) 2022-03-24
KR20210118889A (ko) 2021-10-01
JP2022518495A (ja) 2022-03-15
MX2021008717A (es) 2021-10-26
MX2025009723A (es) 2025-09-02
AU2020212019A1 (en) 2021-09-16
IL284797A (en) 2021-08-31

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