CN118105390A - 治疗成瘾的方法 - Google Patents
治疗成瘾的方法 Download PDFInfo
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- CN118105390A CN118105390A CN202311661516.6A CN202311661516A CN118105390A CN 118105390 A CN118105390 A CN 118105390A CN 202311661516 A CN202311661516 A CN 202311661516A CN 118105390 A CN118105390 A CN 118105390A
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
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|---|---|---|---|
| US201962795899P | 2019-01-23 | 2019-01-23 | |
| US62/795,899 | 2019-01-23 | ||
| CN202080010604.8A CN113329742A (zh) | 2019-01-23 | 2020-01-23 | 治疗成瘾的方法 |
| PCT/US2020/014818 WO2020154519A2 (en) | 2019-01-23 | 2020-01-23 | Methods of treating addiction |
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| CN202080010604.8A Division CN113329742A (zh) | 2019-01-23 | 2020-01-23 | 治疗成瘾的方法 |
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| CN118105390A true CN118105390A (zh) | 2024-05-31 |
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| CN202080010604.8A Pending CN113329742A (zh) | 2019-01-23 | 2020-01-23 | 治疗成瘾的方法 |
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| CN202080010604.8A Pending CN113329742A (zh) | 2019-01-23 | 2020-01-23 | 治疗成瘾的方法 |
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| US (1) | US20220088014A1 (https=) |
| EP (1) | EP3914235A4 (https=) |
| JP (1) | JP7555343B2 (https=) |
| KR (1) | KR102928755B1 (https=) |
| CN (2) | CN118105390A (https=) |
| AU (1) | AU2020212019B2 (https=) |
| CA (1) | CA3125777A1 (https=) |
| IL (1) | IL284797A (https=) |
| MX (2) | MX2021008717A (https=) |
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| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| JP7520013B2 (ja) | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| IL315005B2 (en) | 2018-12-17 | 2026-04-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| JP7649743B2 (ja) | 2018-12-21 | 2025-03-21 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| MX2024004725A (es) * | 2021-10-19 | 2024-05-10 | Intra Cellular Therapies Inc | Metodos novedosos. |
| CN116210637A (zh) * | 2021-12-06 | 2023-06-06 | 中国科学院深圳先进技术研究院 | 一种成瘾药物戒断后复吸相关调控基因及其筛选方法 |
| WO2024145659A1 (en) * | 2022-12-30 | 2024-07-04 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor |
| WO2025257090A1 (en) | 2024-06-10 | 2025-12-18 | Interquim, S.A. | Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues |
| CN119912455B (zh) * | 2025-01-22 | 2025-09-23 | 成都臻拓医药科技有限公司 | 一种卢美哌隆中间体化合物的制备方法 |
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| ATE277048T1 (de) * | 1999-06-15 | 2004-10-15 | Bristol Myers Squibb Pharma Co | Substituierte hetercyclisch kondensierte gamma carboline |
| PL3838274T3 (pl) * | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| WO2018126140A1 (en) * | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3562484B1 (en) * | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
| EP3658144B1 (en) * | 2017-07-26 | 2022-01-26 | Intra-Cellular Therapies, Inc. | Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy |
| WO2019023062A1 (en) * | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
| EP3801527B1 (en) * | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
| JP7649743B2 (ja) * | 2018-12-21 | 2025-03-21 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
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| CN113329742A (zh) | 2021-08-31 |
| AU2020212019B2 (en) | 2025-04-17 |
| EP3914235A2 (en) | 2021-12-01 |
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| WO2020154519A3 (en) | 2020-09-17 |
| EP3914235A4 (en) | 2022-09-07 |
| JP7555343B2 (ja) | 2024-09-24 |
| WO2020154519A2 (en) | 2020-07-30 |
| KR102928755B1 (ko) | 2026-02-19 |
| US20220088014A1 (en) | 2022-03-24 |
| KR20210118889A (ko) | 2021-10-01 |
| JP2022518495A (ja) | 2022-03-15 |
| MX2021008717A (es) | 2021-10-26 |
| MX2025009723A (es) | 2025-09-02 |
| AU2020212019A1 (en) | 2021-09-16 |
| IL284797A (en) | 2021-08-31 |
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