KR102906454B1 - 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법 - Google Patents

발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법

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KR102906454B1
KR102906454B1 KR1020237020953A KR20237020953A KR102906454B1 KR 102906454 B1 KR102906454 B1 KR 102906454B1 KR 1020237020953 A KR1020237020953 A KR 1020237020953A KR 20237020953 A KR20237020953 A KR 20237020953A KR 102906454 B1 KR102906454 B1 KR 102906454B1
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로버트 밥
다리야 부라코프
강 첸
제임스 피. 팬들
유 자오
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리제너론 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020237020953A 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법 Active KR102906454B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257043281A KR20260011194A (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662325400P 2016-04-20 2016-04-20
US62/325,400 2016-04-20
PCT/US2017/028555 WO2017184832A1 (en) 2016-04-20 2017-04-20 Compositions and methods for making antibodies based on use of expression-enhancing loci
KR1020187029365A KR102547738B1 (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법

Related Parent Applications (1)

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KR20230098361A KR20230098361A (ko) 2023-07-03
KR102906454B1 true KR102906454B1 (ko) 2026-01-02

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KR1020237020953A Active KR102906454B1 (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법
KR1020187029365A Active KR102547738B1 (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법
KR1020257043281A Pending KR20260011194A (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법

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KR1020187029365A Active KR102547738B1 (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법
KR1020257043281A Pending KR20260011194A (ko) 2016-04-20 2017-04-20 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법

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US (2) US11512144B2 (enExample)
EP (1) EP3445781A1 (enExample)
JP (4) JP7096770B2 (enExample)
KR (3) KR102906454B1 (enExample)
CN (2) CN109195986B (enExample)
AR (1) AR109451A1 (enExample)
AU (2) AU2017253241B2 (enExample)
BR (1) BR112018071283A2 (enExample)
CA (1) CA3015389A1 (enExample)
EA (1) EA201892010A1 (enExample)
IL (2) IL262266B2 (enExample)
MX (2) MX2018012868A (enExample)
SG (2) SG10202010155YA (enExample)
TW (2) TW202415767A (enExample)
WO (1) WO2017184832A1 (enExample)

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AU2020308002A1 (en) * 2019-06-26 2022-01-20 Genentech, Inc. Randomized configuration targeted integration of nucleic acids
US20230304062A1 (en) 2021-10-18 2023-09-28 Regeneron Pharmaceuticals, Inc. Controlled transcription of polynucleotides
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TW202334402A (zh) 2021-10-18 2023-09-01 美商再生元醫藥公司 包含整合ｃａｓ９基因以產生穩定整合位點的哺乳動物細胞，以及包含穩定整合位點及其他位點的哺乳動物細胞
EP4453227A1 (en) * 2021-12-22 2024-10-30 Genentech, Inc. Multi-vector recombinase mediated cassette exchange
US20250361524A1 (en) * 2022-06-10 2025-11-27 Fujifilm Diosynth Biotechnologies Uk Limited Method for producing cells, method for producing heteromultimeric protein, method for producing bispecific antibody, and method for producing vector set, mammalian cells, CHO cells, and cell pool
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TW202540433A (zh) 2023-11-21 2025-10-16 美商再生元醫藥公司 藉由活體外接合產生共價表面修飾之腺相關病毒及共價表面修飾的腺相關病毒之純化
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AU2017253241A1 (en) 2018-09-20
US11512144B2 (en) 2022-11-29
MX2025003852A (es) 2025-05-02
SG11201807885PA (en) 2018-10-30
TW202415767A (zh) 2024-04-16
AU2017253241B2 (en) 2024-07-04
IL314779A (en) 2024-10-01
SG10202010155YA (en) 2020-11-27
IL262266A (en) 2018-11-29
JP2021164479A (ja) 2021-10-14
US20190233544A1 (en) 2019-08-01
US12528883B2 (en) 2026-01-20
TW201803986A (zh) 2018-02-01
CN116515757A (zh) 2023-08-01
WO2017184832A1 (en) 2017-10-26
CA3015389A1 (en) 2017-10-26
IL262266B2 (en) 2025-01-01
US20230130799A1 (en) 2023-04-27
JP2025188169A (ja) 2025-12-25
CN109195986B (zh) 2023-01-03
TWI827531B (zh) 2024-01-01
JP2019515666A (ja) 2019-06-13
JP2024023449A (ja) 2024-02-21
KR20230098361A (ko) 2023-07-03
CN109195986A (zh) 2019-01-11
JP7096770B2 (ja) 2022-07-06
KR102547738B1 (ko) 2023-06-26
JP7781128B2 (ja) 2025-12-05
MX2018012868A (es) 2019-03-11
AU2024220124A1 (en) 2024-10-17
IL262266B1 (en) 2024-09-01
KR20260011194A (ko) 2026-01-22
EA201892010A1 (ru) 2019-03-29
KR20180134893A (ko) 2018-12-19
BR112018071283A2 (pt) 2019-02-12
EP3445781A1 (en) 2019-02-27
AR109451A1 (es) 2018-12-12

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