KR102890891B1 - 지질 합성의 헤테로사이클릭 조절인자 - Google Patents

지질 합성의 헤테로사이클릭 조절인자

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Publication number
KR102890891B1
KR102890891B1 KR1020247007294A KR20247007294A KR102890891B1 KR 102890891 B1 KR102890891 B1 KR 102890891B1 KR 1020247007294 A KR1020247007294 A KR 1020247007294A KR 20247007294 A KR20247007294 A KR 20247007294A KR 102890891 B1 KR102890891 B1 KR 102890891B1
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South Korea
Prior art keywords
alkyl
halogen
cycloalkyl
straight
membered heterocycle
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KR1020247007294A
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English (en)
Korean (ko)
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KR20240036703A (ko
Inventor
더글라스 아이. 버클리
그레고리 듀크
앨런 에스. 와그먼
마크 에반칙
로버트 에스. 맥도웰
Original Assignee
새지메트 바이오사이언시스, 인코포레이티드
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Priority claimed from US15/349,960 external-priority patent/US20170119786A1/en
Application filed by 새지메트 바이오사이언시스, 인코포레이티드 filed Critical 새지메트 바이오사이언시스, 인코포레이티드
Priority to KR1020257039033A priority Critical patent/KR20250169632A/ko
Publication of KR20240036703A publication Critical patent/KR20240036703A/ko
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4164—1,3-Diazoles
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN110078613B (zh) * 2019-05-31 2022-04-22 杭州科耀医药科技有限公司 一种2-卤-5-碘苯甲酸的合成方法
TW202128664A (zh) 2019-10-09 2021-08-01 德商拜耳廠股份有限公司 作為除害劑之新穎雜芳基三唑化合物
CN114469945A (zh) * 2020-10-28 2022-05-13 歌礼生物科技（杭州）有限公司 脂肪酸合酶抑制剂的用途和药物组合物
US20250166821A1 (en) * 2021-11-11 2025-05-22 Sagimet Biosciences Inc. Methods for prediction of treatment response in non-alcoholic fatty liver disease
CN114436979B (zh) * 2022-02-22 2024-03-26 成都化润药业有限公司 一种合成1,2,4-三氮唑-3-羧酸甲酯的方法
JPWO2024172156A1 (enExample) * 2023-02-16 2024-08-22
CN119080742A (zh) * 2023-06-05 2024-12-06 甘莱制药有限公司 脂质合成的杂环调节剂的工业化制备
WO2025086054A1 (zh) * 2023-10-23 2025-05-01 歌礼生物科技（杭州）有限公司 一种包含苯甲腈衍生物的药物组合物
CN119868349A (zh) * 2023-10-23 2025-04-25 歌礼生物科技（杭州）有限公司 一种包含苯甲腈衍生物的药物组合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
WO2007052843A1 (ja) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
RU2396269C2 (ru) 2005-12-01 2010-08-10 Ф.Хоффманн-Ля Рош Аг Производные гетероарилзамещенного пиперидина в качестве ингибиторов печеночной карнитин пальмитоилтрансферазы (l-cpt1)
JP2010502731A (ja) 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
WO2008075077A1 (en) 2006-12-21 2008-06-26 Astrazeneca Ab Piperidine derivatives for the treatment of obesity
TW200833663A (en) 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
TW200831092A (en) 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
EP2485678A4 (en) 2009-10-07 2013-04-03 Univ Cornell Coferons and methods of making and using them
AU2011218830B2 (en) * 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
US9624173B2 (en) * 2011-03-08 2017-04-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI522348B (zh) 2011-03-08 2016-02-21 ３ Ｖ生物科技公司 脂質合成之雜環調節劑
EP2683244B1 (en) * 2011-03-08 2017-02-01 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
EP2870150B1 (en) 2012-07-03 2019-06-19 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
CA2884355C (en) * 2012-09-07 2022-05-17 Janssen Pharmaceutica Nv Imidazolin-5-one derivative useful as fasn inhobitors for the treatment of cancer
EP3077387B1 (en) * 2013-12-03 2017-12-20 Janssen Pharmaceutica NV Benzamide derivative useful as fasn inhibitors for the treatment of cancer
JP6617106B2 (ja) * 2013-12-17 2019-12-04 ヤンセン ファーマシューティカ エヌ．ベー． 癌の治療用のｆａｓｎ阻害剤として有用なイミダゾリン−５−オン誘導体
CA2934251C (en) * 2013-12-20 2024-01-02 3-V Biosciences, Inc. A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
RU2766087C2 (ru) 2014-01-07 2022-02-07 Сагимет Байосайенсиз Инк. Гетероциклические модуляторы синтеза липидов для применения против рака и вирусных инфекций
RS57384B1 (sr) * 2014-03-17 2018-09-28 Pfizer Inhibitori diacilglicerol aciltransferaze 2 za upotrebu u tretmanu metaboličkih i srodnih poremećaja
KR102504168B1 (ko) * 2014-08-15 2023-02-27 새지메트 바이오사이언시스, 인코포레이티드 약물 내성 암의 치료에서 사용하기 위한 지방산 신타제 억제제
ES2910049T3 (es) * 2015-03-19 2022-05-11 Sagimet Biosciences Inc Moduladores heterocíclicos de la síntesis de lípidos

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Investigative Dermatology (2014), Volume 134*
Molecular Medicine volume 20, pages1-9 (2014)*

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