KR102811519B1 - 간세포성 암종의 치료를 위한 조합 요법 - Google Patents

간세포성 암종의 치료를 위한 조합 요법 Download PDF

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KR102811519B1
KR102811519B1 KR1020207022999A KR20207022999A KR102811519B1 KR 102811519 B1 KR102811519 B1 KR 102811519B1 KR 1020207022999 A KR1020207022999 A KR 1020207022999A KR 20207022999 A KR20207022999 A KR 20207022999A KR 102811519 B1 KR102811519 B1 KR 102811519B1
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pharmaceutically acceptable
acid
acceptable salt
lenvatinib
compound
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Korean (ko)
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KR20200121302A (ko
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아난드 셀바라즈
피터 스미스
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020207022999A 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법 Active KR102811519B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257016389A KR20250073570A (ko) 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862615848P 2018-01-10 2018-01-10
US62/615,848 2018-01-10
PCT/US2019/012886 WO2019139977A1 (en) 2018-01-10 2019-01-09 Combination therapies for the treatment of hepatocellular carcinoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257016389A Division KR20250073570A (ko) 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법

Publications (2)

Publication Number Publication Date
KR20200121302A KR20200121302A (ko) 2020-10-23
KR102811519B1 true KR102811519B1 (ko) 2025-05-22

Family

ID=65411938

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207022999A Active KR102811519B1 (ko) 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법
KR1020257016389A Pending KR20250073570A (ko) 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257016389A Pending KR20250073570A (ko) 2018-01-10 2019-01-09 간세포성 암종의 치료를 위한 조합 요법

Country Status (13)

Country Link
US (1) US11833119B2 (https=)
EP (2) EP3737377B1 (https=)
JP (2) JP7352569B2 (https=)
KR (2) KR102811519B1 (https=)
CN (1) CN111787922A (https=)
AU (1) AU2019206480A1 (https=)
BR (1) BR112020014112A2 (https=)
CA (1) CA3088292A1 (https=)
IL (1) IL275981A (https=)
MA (1) MA51570A (https=)
MX (1) MX2020007375A (https=)
SG (1) SG11202006617RA (https=)
WO (1) WO2019139977A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法
CN117479958A (zh) * 2022-05-30 2024-01-30 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160089365A1 (en) 2014-09-25 2016-03-31 Eisai R&D Management Co., Ltd. Immunostimulatory compound
WO2017196854A1 (en) 2016-05-10 2017-11-16 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60137273D1 (de) 2000-10-20 2009-02-12 Eisai R&D Man Co Ltd Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten
PL1698623T3 (pl) 2003-12-25 2015-08-31 Eisai R&D Man Co Ltd Postać krystaliczna soli 4-(3-chloro-4-(cyklopropyloaminokarbonylo)aminofenoksy)-7-metoksy-6-chinolinokarboksamidu lub jej solwatu i sposoby ich wytwarzania
RU2448708C3 (ru) 2006-05-18 2017-09-28 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое средство против рака щитовидной железы
KR101513326B1 (ko) 2007-11-09 2015-04-17 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 항종양성 백금 착물의 병용
JP2015505562A (ja) * 2012-01-31 2015-02-23 ノバルティス アーゲー Ｒｔｋ阻害剤と抗エストロゲン剤との組合せ、およびがん治療のためのその使用
KR102265952B1 (ko) 2013-06-26 2021-06-16 에자이 알앤드디 매니지먼트 가부시키가이샤 암 치료 병용요법으로서 에리불린 및 렌바티닙의 용도
MX378288B (es) 2013-10-18 2025-03-10 Eisai R&D Man Co Ltd Inhibidores de pirimidina del fgfr4.
MX373150B (es) * 2014-03-26 2020-04-21 Astex Therapeutics Ltd Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r).
SG10201810057UA (en) 2015-04-14 2018-12-28 Eisai R&D Man Co Ltd Crystalline fgfr4 inhibitor compound and uses thereof
CN107304188A (zh) * 2016-04-20 2017-10-31 成都融科博海科技有限公司 一种氘代激酶选择性抑制剂及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160089365A1 (en) 2014-09-25 2016-03-31 Eisai R&D Management Co., Ltd. Immunostimulatory compound
WO2017196854A1 (en) 2016-05-10 2017-11-16 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation

Also Published As

Publication number Publication date
US20200360371A1 (en) 2020-11-19
US11833119B2 (en) 2023-12-05
CN111787922A (zh) 2020-10-16
MX2020007375A (es) 2020-11-09
JP2023175825A (ja) 2023-12-12
JP7665700B2 (ja) 2025-04-21
RU2020126673A (ru) 2022-02-10
WO2019139977A1 (en) 2019-07-18
KR20250073570A (ko) 2025-05-27
KR20200121302A (ko) 2020-10-23
AU2019206480A1 (en) 2020-08-27
MA51570A (fr) 2020-11-18
EP3737377A1 (en) 2020-11-18
SG11202006617RA (en) 2020-08-28
BR112020014112A2 (pt) 2020-12-01
IL275981A (en) 2020-08-31
JP7352569B2 (ja) 2023-09-28
CA3088292A1 (en) 2019-07-18
EP4667005A2 (en) 2025-12-24
JP2021512140A (ja) 2021-05-13
EP3737377B1 (en) 2025-10-08
EP4667005A3 (en) 2026-02-18
RU2020126673A3 (https=) 2022-04-19

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