CN111787922A - 用于治疗肝细胞癌的组合疗法 - Google Patents

用于治疗肝细胞癌的组合疗法 Download PDF

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Publication number
CN111787922A
CN111787922A CN201980015321.XA CN201980015321A CN111787922A CN 111787922 A CN111787922 A CN 111787922A CN 201980015321 A CN201980015321 A CN 201980015321A CN 111787922 A CN111787922 A CN 111787922A
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CN
China
Prior art keywords
pharmaceutically acceptable
acceptable salt
phenyl
dichloro
acrylamide
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Pending
Application number
CN201980015321.XA
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English (en)
Chinese (zh)
Inventor
阿南德·瑟瓦拉
P·史密斯
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Sanitary Material R&d Management Co ltd
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Sanitary Material R&d Management Co ltd
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Publication of CN111787922A publication Critical patent/CN111787922A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201980015321.XA 2018-01-10 2019-01-09 用于治疗肝细胞癌的组合疗法 Pending CN111787922A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862615848P 2018-01-10 2018-01-10
US62/615,848 2018-01-10
PCT/US2019/012886 WO2019139977A1 (en) 2018-01-10 2019-01-09 Combination therapies for the treatment of hepatocellular carcinoma

Publications (1)

Publication Number Publication Date
CN111787922A true CN111787922A (zh) 2020-10-16

Family

ID=65411938

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980015321.XA Pending CN111787922A (zh) 2018-01-10 2019-01-09 用于治疗肝细胞癌的组合疗法

Country Status (13)

Country Link
US (1) US11833119B2 (https=)
EP (2) EP4667005A3 (https=)
JP (2) JP7352569B2 (https=)
KR (2) KR102811519B1 (https=)
CN (1) CN111787922A (https=)
AU (1) AU2019206480A1 (https=)
BR (1) BR112020014112A2 (https=)
CA (1) CA3088292A1 (https=)
IL (1) IL275981A (https=)
MA (1) MA51570A (https=)
MX (1) MX2020007375A (https=)
SG (1) SG11202006617RA (https=)
WO (1) WO2019139977A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023232012A1 (zh) 2022-05-30 2023-12-07 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101848895A (zh) * 2007-11-09 2010-09-29 卫材R&D管理有限公司 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
CN104093402A (zh) * 2012-01-31 2014-10-08 诺华股份有限公司 Rtk抑制剂与抗雌激素的组合及其治疗癌症的应用
CN105338977A (zh) * 2013-06-26 2016-02-17 卫材R&D管理有限公司 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途
US20160089365A1 (en) * 2014-09-25 2016-03-31 Eisai R&D Management Co., Ltd. Immunostimulatory compound
CN106456648A (zh) * 2014-03-26 2017-02-22 阿斯特克斯治疗有限公司 Fgfr抑制剂和igf1r抑制剂的组合
CN107304188A (zh) * 2016-04-20 2017-10-31 成都融科博海科技有限公司 一种氘代激酶选择性抑制剂及其应用
WO2017196854A1 (en) * 2016-05-10 2017-11-16 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9598601A (en) 2000-10-20 2002-04-29 Eisai Co Ltd Nitrogenous aromatic ring compounds
KR100804566B1 (ko) 2003-12-25 2008-02-20 에자이 알앤드디 매니지먼트 가부시키가이샤 4-(3-클로로-4-(시클로프로필아미노카르보닐)아미노페녹시)-7-메톡시-6-퀴놀린카르복사미드의 염 또는 그 용매화물의 결정 및 이들의 제조 방법
CN104706637A (zh) 2006-05-18 2015-06-17 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
PH12016500676B1 (en) * 2013-10-18 2022-07-20 Eisai R&D Man Co Ltd Pyrimidine fgfr4 inhibitors
KR102548229B1 (ko) 2015-04-14 2023-06-27 에자이 알앤드디 매니지먼트 가부시키가이샤 결정질 fgfr4 억제제 화합물 및 그의 용도

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101848895A (zh) * 2007-11-09 2010-09-29 卫材R&D管理有限公司 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
CN104093402A (zh) * 2012-01-31 2014-10-08 诺华股份有限公司 Rtk抑制剂与抗雌激素的组合及其治疗癌症的应用
CN105338977A (zh) * 2013-06-26 2016-02-17 卫材R&D管理有限公司 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途
CN106456648A (zh) * 2014-03-26 2017-02-22 阿斯特克斯治疗有限公司 Fgfr抑制剂和igf1r抑制剂的组合
US20160089365A1 (en) * 2014-09-25 2016-03-31 Eisai R&D Management Co., Ltd. Immunostimulatory compound
CN107304188A (zh) * 2016-04-20 2017-10-31 成都融科博海科技有限公司 一种氘代激酶选择性抑制剂及其应用
WO2017196854A1 (en) * 2016-05-10 2017-11-16 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023232012A1 (zh) 2022-05-30 2023-12-07 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物
CN117479958A (zh) * 2022-05-30 2024-01-30 石药集团中奇制药技术（石家庄）有限公司 用于治疗癌症的药物组合和药物组合物

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Publication number Publication date
IL275981A (en) 2020-08-31
JP7665700B2 (ja) 2025-04-21
US11833119B2 (en) 2023-12-05
MX2020007375A (es) 2020-11-09
EP4667005A2 (en) 2025-12-24
JP2021512140A (ja) 2021-05-13
MA51570A (fr) 2020-11-18
RU2020126673A3 (https=) 2022-04-19
EP3737377A1 (en) 2020-11-18
EP4667005A3 (en) 2026-02-18
WO2019139977A1 (en) 2019-07-18
US20200360371A1 (en) 2020-11-19
AU2019206480A1 (en) 2020-08-27
KR20200121302A (ko) 2020-10-23
KR102811519B1 (ko) 2025-05-22
BR112020014112A2 (pt) 2020-12-01
EP3737377B1 (en) 2025-10-08
JP7352569B2 (ja) 2023-09-28
KR20250073570A (ko) 2025-05-27
JP2023175825A (ja) 2023-12-12
RU2020126673A (ru) 2022-02-10
CA3088292A1 (en) 2019-07-18
SG11202006617RA (en) 2020-08-28

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