KR102811061B1 - 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템과 방법 및 이들의 질환 모형 - Google Patents

생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템과 방법 및 이들의 질환 모형 Download PDF

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KR102811061B1
KR102811061B1 KR1020187023347A KR20187023347A KR102811061B1 KR 102811061 B1 KR102811061 B1 KR 102811061B1 KR 1020187023347 A KR1020187023347 A KR 1020187023347A KR 20187023347 A KR20187023347 A KR 20187023347A KR 102811061 B1 KR102811061 B1 KR 102811061B1
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cells
promoter
recombinase
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KR20180101535A (ko
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조슈아 브레유닉
모이즈 다니엘퍼
기범 김
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세다르스-신나이 메디칼 센터
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KR1020187023347A 2016-01-26 2016-12-30 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템과 방법 및 이들의 질환 모형 Active KR102811061B1 (ko)

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US201662287197P 2016-01-26 2016-01-26
US62/287,197 2016-01-26
PCT/US2016/069442 WO2017131926A1 (en) 2016-01-26 2016-12-30 SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF

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KR102811061B1 true KR102811061B1 (ko) 2025-05-21

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US (2) US11466290B2 (https=)
EP (1) EP3408396A4 (https=)
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CN (1) CN108884472A (https=)
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JP2019511243A (ja) 2016-01-26 2019-04-25 シーダーズ−サイナイ メディカル センター インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル
US12258571B2 (en) 2018-03-16 2025-03-25 Cedars-Sinai Medical Center Methods and compositions for inducible expression of neurotrophic factors
CN109321599B (zh) * 2018-09-27 2023-08-22 同济大学 人多能干细胞中的谱系示踪系统的构建与应用
CN109943564B (zh) * 2019-03-28 2022-03-15 上海市中医老年医学研究所 Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用
CA3143981A1 (en) * 2019-06-17 2020-12-24 Cedars-Sinai Medical Center Systems and methods for in vivo dual recombinase-mediated cassette exchange (drmce) and disease models thereof
CN118547004A (zh) * 2019-06-19 2024-08-27 豪夫迈·罗氏有限公司 通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法
US20250354186A1 (en) 2022-06-06 2025-11-20 Kyowa Hakko Bio Co., Ltd. Microorganism having improved 3'-sialyllactose productivity and production method of 3'-sialyllactose

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EP3408396A1 (en) 2018-12-05
KR20180101535A (ko) 2018-09-12
US20230084201A1 (en) 2023-03-16
AU2016389495A1 (en) 2018-08-16
JP2019511243A (ja) 2019-04-25
WO2017131926A1 (en) 2017-08-03
EP3408396A4 (en) 2019-10-09
CA3012042A1 (en) 2017-08-03
CN108884472A (zh) 2018-11-23
US11466290B2 (en) 2022-10-11
JP2022091801A (ja) 2022-06-21
JP2024063065A (ja) 2024-05-10
US20190390222A1 (en) 2019-12-26
AU2016389495B2 (en) 2023-03-30

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