KR102803161B1 - 윌슨병을 치료하기 위한 비스-콜린 테트라티오몰리브데이트 - Google Patents
윌슨병을 치료하기 위한 비스-콜린 테트라티오몰리브데이트 Download PDFInfo
- Publication number
- KR102803161B1 KR102803161B1 KR1020207019115A KR20207019115A KR102803161B1 KR 102803161 B1 KR102803161 B1 KR 102803161B1 KR 1020207019115 A KR1020207019115 A KR 1020207019115A KR 20207019115 A KR20207019115 A KR 20207019115A KR 102803161 B1 KR102803161 B1 KR 102803161B1
- Authority
- KR
- South Korea
- Prior art keywords
- bis
- choline tetrathiomolybdate
- patient
- delete delete
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594184P | 2017-12-04 | 2017-12-04 | |
| US62/594,184 | 2017-12-04 | ||
| US201862646553P | 2018-03-22 | 2018-03-22 | |
| US62/646,553 | 2018-03-22 | ||
| US201862655568P | 2018-04-10 | 2018-04-10 | |
| US62/655,568 | 2018-04-10 | ||
| US201862669095P | 2018-05-09 | 2018-05-09 | |
| US62/669,095 | 2018-05-09 | ||
| US201862741313P | 2018-10-04 | 2018-10-04 | |
| US62/741,313 | 2018-10-04 | ||
| US201862750595P | 2018-10-25 | 2018-10-25 | |
| US62/750,595 | 2018-10-25 | ||
| PCT/EP2018/083551 WO2019110619A1 (en) | 2017-12-04 | 2018-12-04 | Bis-choline tetrathiomolybdate for treating wilson disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200096798A KR20200096798A (ko) | 2020-08-13 |
| KR102803161B1 true KR102803161B1 (ko) | 2025-05-07 |
Family
ID=64661349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207019115A Active KR102803161B1 (ko) | 2017-12-04 | 2018-12-04 | 윌슨병을 치료하기 위한 비스-콜린 테트라티오몰리브데이트 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11510944B2 (https=) |
| EP (3) | EP4523745A3 (https=) |
| JP (3) | JP7852200B2 (https=) |
| KR (1) | KR102803161B1 (https=) |
| AU (1) | AU2018379255B2 (https=) |
| BR (1) | BR112020011055A2 (https=) |
| DK (2) | DK4029498T3 (https=) |
| ES (2) | ES3026756T3 (https=) |
| FI (1) | FI4029498T3 (https=) |
| HU (2) | HUE071155T2 (https=) |
| IL (1) | IL275115B2 (https=) |
| MX (1) | MX2020006284A (https=) |
| PL (2) | PL4029498T3 (https=) |
| PT (2) | PT4029498T (https=) |
| SI (2) | SI4029498T1 (https=) |
| WO (1) | WO2019110619A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11419832B2 (en) * | 2017-12-04 | 2022-08-23 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating Wilson Disease |
| MX2020006284A (es) * | 2017-12-04 | 2021-04-12 | Alexion Pharma Int Operations Unlimited Company | Tetratiomolibdato de bis-colina para tratar la enfermedad de wilson. |
| WO2019154876A1 (en) | 2018-02-06 | 2019-08-15 | Wilson Therapeutics Ab | Crystalline particles of bis-choline tetrathiomolybdate |
| US20220387370A1 (en) | 2019-11-21 | 2022-12-08 | Alexion Pharmaceuticals, Inc. | Methods of reducing neurological damage in wilson disease patients |
| CN116601173A (zh) * | 2020-09-11 | 2023-08-15 | 阿雷克森制药公司 | 抗铜蓝蛋白抗体及其用途 |
| EP4243806A1 (en) * | 2020-11-13 | 2023-09-20 | Alexion Pharmaceuticals, Inc. | Methods of treating copper metabolism-associated diseases or disorders |
| JP2024505229A (ja) * | 2021-01-31 | 2024-02-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 銅代謝関連疾患又は障害を治療するための新規製剤 |
| WO2023023199A1 (en) | 2021-08-17 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods of treating copper metabolism-associated diseases or disorders |
| WO2024162974A1 (en) | 2023-01-30 | 2024-08-08 | Alexion Pharmaceuticals, Inc. | Tetrathiomolybdic acid for use in treating copper metabolism-associated diseases or disorders (wilson disease) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7189865B2 (en) | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
| GEP20074270B (en) * | 2002-07-23 | 2007-12-25 | Univ Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
| CA2675230A1 (en) | 2006-01-10 | 2008-07-26 | Pipex, Inc. | Pharmaceutical compositions and methods to achieve and maintain a targeted and stable copper status and prevent and treat copper-related central nervous system diseases |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US11419832B2 (en) * | 2017-12-04 | 2022-08-23 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating Wilson Disease |
| MX2020006284A (es) | 2017-12-04 | 2021-04-12 | Alexion Pharma Int Operations Unlimited Company | Tetratiomolibdato de bis-colina para tratar la enfermedad de wilson. |
| WO2019154876A1 (en) | 2018-02-06 | 2019-08-15 | Wilson Therapeutics Ab | Crystalline particles of bis-choline tetrathiomolybdate |
-
2018
- 2018-12-04 MX MX2020006284A patent/MX2020006284A/es unknown
- 2018-12-04 PL PL21215264.9T patent/PL4029498T3/pl unknown
- 2018-12-04 US US16/770,022 patent/US11510944B2/en active Active
- 2018-12-04 IL IL275115A patent/IL275115B2/en unknown
- 2018-12-04 SI SI201831229T patent/SI4029498T1/sl unknown
- 2018-12-04 HU HUE21215264A patent/HUE071155T2/hu unknown
- 2018-12-04 FI FIEP21215264.9T patent/FI4029498T3/fi active
- 2018-12-04 PT PT212152649T patent/PT4029498T/pt unknown
- 2018-12-04 DK DK21215264.9T patent/DK4029498T3/da active
- 2018-12-04 HU HUE18815624A patent/HUE058921T2/hu unknown
- 2018-12-04 AU AU2018379255A patent/AU2018379255B2/en active Active
- 2018-12-04 DK DK18815624.4T patent/DK3720433T3/da active
- 2018-12-04 ES ES21215264T patent/ES3026756T3/es active Active
- 2018-12-04 EP EP25154707.1A patent/EP4523745A3/en active Pending
- 2018-12-04 JP JP2020547315A patent/JP7852200B2/ja active Active
- 2018-12-04 PL PL18815624.4T patent/PL3720433T3/pl unknown
- 2018-12-04 WO PCT/EP2018/083551 patent/WO2019110619A1/en not_active Ceased
- 2018-12-04 KR KR1020207019115A patent/KR102803161B1/ko active Active
- 2018-12-04 EP EP21215264.9A patent/EP4029498B1/en active Active
- 2018-12-04 SI SI201830650T patent/SI3720433T1/sl unknown
- 2018-12-04 PT PT188156244T patent/PT3720433T/pt unknown
- 2018-12-04 BR BR112020011055-8A patent/BR112020011055A2/pt unknown
- 2018-12-04 ES ES18815624T patent/ES2912306T3/es active Active
- 2018-12-04 EP EP18815624.4A patent/EP3720433B1/en active Active
-
2021
- 2021-02-22 US US17/182,227 patent/US20210177894A1/en not_active Abandoned
-
2022
- 2022-08-23 US US17/821,786 patent/US12233088B2/en active Active
-
2023
- 2023-03-13 JP JP2023038205A patent/JP2023075247A/ja active Pending
-
2025
- 2025-01-24 JP JP2025010250A patent/JP2025066802A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| The Lancet, Gastroenterology & Hepatology, 2(12), 869-876, 2017. |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20200702 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
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| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20211203 Comment text: Request for Examination of Application |
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| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20240701 Patent event code: PE09021S01D |
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| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20250203 |
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| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20250428 Patent event code: PR07011E01D |
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| PR1002 | Payment of registration fee |
Payment date: 20250428 End annual number: 3 Start annual number: 1 |
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| PG1601 | Publication of registration |