KR102779525B1 - 폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 - Google Patents

폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 Download PDF

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KR102779525B1
KR102779525B1 KR1020177035856A KR20177035856A KR102779525B1 KR 102779525 B1 KR102779525 B1 KR 102779525B1 KR 1020177035856 A KR1020177035856 A KR 1020177035856A KR 20177035856 A KR20177035856 A KR 20177035856A KR 102779525 B1 KR102779525 B1 KR 102779525B1
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polynucleotide
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크리스티아나 귀두치
로버트 엘. 코프만
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다이나박스 테크놀로지 코퍼레이션
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177035856A 2015-05-29 2016-05-23 폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 Active KR102779525B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562168449P 2015-05-29 2015-05-29
US201562168470P 2015-05-29 2015-05-29
US62/168,470 2015-05-29
US62/168,449 2015-05-29
US201562169321P 2015-06-01 2015-06-01
US201562169309P 2015-06-01 2015-06-01
US62/169,321 2015-06-01
US62/169,309 2015-06-01
US201662276767P 2016-01-08 2016-01-08
US62/276,767 2016-01-08
PCT/US2016/033817 WO2016196062A1 (en) 2015-05-29 2016-05-23 Intrapulmonary administration of polynucleotide toll-like receptor 9 agonists for treating cancer of the lung

Publications (2)

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KR20180021700A KR20180021700A (ko) 2018-03-05
KR102779525B1 true KR102779525B1 (ko) 2025-03-12

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US (3) US9993495B2 (https=)
EP (2) EP3302502B1 (https=)
JP (1) JP6792294B2 (https=)
KR (1) KR102779525B1 (https=)
CN (1) CN107708706A (https=)
AU (1) AU2016270782B2 (https=)
CA (1) CA2987237A1 (https=)
DK (1) DK3302502T3 (https=)
ES (2) ES2987696T3 (https=)
HK (1) HK1251471A1 (https=)
IL (1) IL255903B (https=)
MX (1) MX381587B (https=)
RU (1) RU2017145940A (https=)
WO (1) WO2016196062A1 (https=)

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JP6991857B2 (ja) * 2014-10-10 2022-01-13 イデラ ファーマシューティカルズ インコーポレイテッド Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療
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WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
MX2019002925A (es) 2016-09-15 2019-09-05 Idera Pharmaceuticals Inc Modulacion inmune con agonistas de tlr9 para el tratamiento del cancer.
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
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KR20210079319A (ko) * 2018-10-18 2021-06-29 도이체스 크렙스포르슝스첸트룸 흡입용 건조 약학적 조성물
CN111321159B (zh) * 2018-12-14 2023-12-12 中天(上海)生物科技有限公司 用于免疫调节的嵌合核酸分子及其应用
US20220370606A1 (en) * 2018-12-21 2022-11-24 Pfizer Inc. Combination Treatments Of Cancer Comprising A TLR Agonist
WO2021007160A1 (en) 2019-07-05 2021-01-14 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
TWI833056B (zh) * 2019-12-31 2024-02-21 財團法人工業技術研究院 核酸藥物複合體以及其用途
CN116056765A (zh) 2020-08-07 2023-05-02 坦伯公司 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途
CN114099535B (zh) * 2020-12-10 2023-01-03 南京吉迈生物技术有限公司 Toll样受体9(TLR9)激动剂水凝胶免疫调节组合物
WO2022140661A1 (en) * 2020-12-23 2022-06-30 Cascade Prodrug Inc. Combination therapy with a vinca alkaloid n-oxide and an immune checkpoint inhibitor
US20250009731A1 (en) 2021-11-08 2025-01-09 Nurix Therapeutics, Inc. Toll-like receptor therapy combinations with cbl-b inhibitor compounds
WO2023141599A2 (en) * 2022-01-21 2023-07-27 Trisalus Life Sciences, Inc. Methods of treating immune dysfunction in liver cancer with toll-like receptor agonists
WO2024186193A1 (ko) * 2023-03-08 2024-09-12 인제대학교 산학협력단 국소적 방사선 치료에서 전신성 항암 치료를 위한 조성물

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CN101134046A (zh) 2006-09-01 2008-03-05 中国医学科学院药物研究所 Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用
US20100184834A1 (en) 2002-12-23 2010-07-22 Dino Dina Immunostimulatory sequence oligonucleotides and methods of using the same

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WO2004058179A2 (en) 2002-12-23 2004-07-15 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US20100184834A1 (en) 2002-12-23 2010-07-22 Dino Dina Immunostimulatory sequence oligonucleotides and methods of using the same
CN101134046A (zh) 2006-09-01 2008-03-05 中国医学科学院药物研究所 Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用

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RU2017145940A3 (https=) 2019-11-26
JP2018521011A (ja) 2018-08-02
US9993495B2 (en) 2018-06-12
EP3302502A1 (en) 2018-04-11
CA2987237A1 (en) 2016-12-08
US20160346312A1 (en) 2016-12-01
AU2016270782B2 (en) 2021-08-12
RU2017145940A (ru) 2019-07-02
ES2752063T3 (es) 2020-04-02
EP3590518B1 (en) 2024-03-20
HK1251471A1 (zh) 2019-02-01
ES2987696T3 (es) 2024-11-15
CN107708706A (zh) 2018-02-16
MX381587B (es) 2025-03-12
US10369168B2 (en) 2019-08-06
DK3302502T3 (da) 2019-10-28
US20190151345A1 (en) 2019-05-23
KR20180021700A (ko) 2018-03-05
EP3590518A1 (en) 2020-01-08
EP3302502B1 (en) 2019-08-28
WO2016196062A1 (en) 2016-12-08
AU2016270782A1 (en) 2017-12-07
JP6792294B2 (ja) 2020-11-25
US10111899B2 (en) 2018-10-30
US20180264023A1 (en) 2018-09-20
IL255903A (en) 2018-01-31
MX2017015294A (es) 2018-02-19
NZ737488A (en) 2024-12-20
IL255903B (en) 2021-09-30

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