KR102775924B1 - Bcl2 억제용 p-에톡시 핵산 - Google Patents

Bcl2 억제용 p-에톡시 핵산 Download PDF

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KR102775924B1
KR102775924B1 KR1020197033985A KR20197033985A KR102775924B1 KR 102775924 B1 KR102775924 B1 KR 102775924B1 KR 1020197033985 A KR1020197033985 A KR 1020197033985A KR 20197033985 A KR20197033985 A KR 20197033985A KR 102775924 B1 KR102775924 B1 KR 102775924B1
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oligonucleotides
cancer
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KR20190141196A (ko
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아나 타리 아쉬자와
피터 닐슨
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바이오-패쓰 홀딩스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

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KR1020197033985A 2017-04-19 2018-04-19 Bcl2 억제용 p-에톡시 핵산 Active KR102775924B1 (ko)

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US201762487302P 2017-04-19 2017-04-19
US62/487,302 2017-04-19
PCT/US2018/028267 WO2018195253A1 (en) 2017-04-19 2018-04-19 P-ethoxy nucleic acids for bcl2 inhibition

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KR102775924B1 true KR102775924B1 (ko) 2025-03-07

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US (1) US12234457B2 (OSRAM)
EP (1) EP3612160A4 (OSRAM)
JP (2) JP7284709B2 (OSRAM)
KR (1) KR102775924B1 (OSRAM)
CN (1) CN110636835A (OSRAM)
AU (1) AU2018254468B2 (OSRAM)
BR (1) BR112019021775A2 (OSRAM)
EA (1) EA201992490A1 (OSRAM)
IL (1) IL269616A (OSRAM)
SG (1) SG11201909649SA (OSRAM)
WO (1) WO2018195253A1 (OSRAM)

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SG11201802718PA (en) 2015-10-14 2018-05-30 Bio Path Holdings Inc P-ethoxy nucleic acids for liposomal formulation
CN109963571A (zh) 2016-09-16 2019-07-02 拜奥-帕斯控股股份有限公司 含有脂质体反义寡核苷酸的组合疗法
EA201992490A1 (ru) 2017-04-19 2020-03-03 Байо-Пат Холдингз, Инк. Р-этокси нуклеиновые кислоты для ингибирования bcl2
AU2018255352B2 (en) 2017-04-19 2023-11-16 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for STAT3 inhibition

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EA201992490A1 (ru) 2020-03-03
KR20190141196A (ko) 2019-12-23
BR112019021775A2 (pt) 2020-05-05
JP2023052819A (ja) 2023-04-12
CN110636835A (zh) 2019-12-31
SG11201909649SA (en) 2019-11-28
US20210123058A1 (en) 2021-04-29
AU2018254468A1 (en) 2019-11-14
JP7284709B2 (ja) 2023-05-31
US12234457B2 (en) 2025-02-25
IL269616A (en) 2019-11-28
EP3612160A4 (en) 2021-01-20
JP2020517646A (ja) 2020-06-18
AU2018254468B2 (en) 2023-11-16
EP3612160A1 (en) 2020-02-26
CA3058486A1 (en) 2018-10-25
WO2018195253A1 (en) 2018-10-25

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