CN110636835A - 用于bcl2抑制的p-乙氧基核酸 - Google Patents

用于bcl2抑制的p-乙氧基核酸 Download PDF

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Publication number
CN110636835A
CN110636835A CN201880033234.2A CN201880033234A CN110636835A CN 110636835 A CN110636835 A CN 110636835A CN 201880033234 A CN201880033234 A CN 201880033234A CN 110636835 A CN110636835 A CN 110636835A
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composition
oligonucleotides
cancer
population
oligonucleotide
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A·T·阿西扎瓦
P·尼尔森
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Bid Pars Cmi Holdings Ltd
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Bid Pars Cmi Holdings Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

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CN201880033234.2A 2017-04-19 2018-04-19 用于bcl2抑制的p-乙氧基核酸 Pending CN110636835A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487302P 2017-04-19 2017-04-19
US62/487,302 2017-04-19
PCT/US2018/028267 WO2018195253A1 (en) 2017-04-19 2018-04-19 P-ethoxy nucleic acids for bcl2 inhibition

Publications (1)

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CN110636835A true CN110636835A (zh) 2019-12-31

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US (1) US12234457B2 (OSRAM)
EP (1) EP3612160A4 (OSRAM)
JP (2) JP7284709B2 (OSRAM)
KR (1) KR102775924B1 (OSRAM)
CN (1) CN110636835A (OSRAM)
AU (1) AU2018254468B2 (OSRAM)
BR (1) BR112019021775A2 (OSRAM)
EA (1) EA201992490A1 (OSRAM)
IL (1) IL269616A (OSRAM)
SG (1) SG11201909649SA (OSRAM)
WO (1) WO2018195253A1 (OSRAM)

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AU2018255352B2 (en) 2017-04-19 2023-11-16 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for STAT3 inhibition

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KR20190141196A (ko) 2019-12-23
BR112019021775A2 (pt) 2020-05-05
KR102775924B1 (ko) 2025-03-07
JP2023052819A (ja) 2023-04-12
SG11201909649SA (en) 2019-11-28
US20210123058A1 (en) 2021-04-29
AU2018254468A1 (en) 2019-11-14
JP7284709B2 (ja) 2023-05-31
US12234457B2 (en) 2025-02-25
IL269616A (en) 2019-11-28
EP3612160A4 (en) 2021-01-20
JP2020517646A (ja) 2020-06-18
AU2018254468B2 (en) 2023-11-16
EP3612160A1 (en) 2020-02-26
CA3058486A1 (en) 2018-10-25
WO2018195253A1 (en) 2018-10-25

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