KR102756047B1 - 디히드로오로테이트 옥시게나제 억제제로서의 삼치환 벤조트리아졸 유도체의 사용 방법 - Google Patents

디히드로오로테이트 옥시게나제 억제제로서의 삼치환 벤조트리아졸 유도체의 사용 방법 Download PDF

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KR102756047B1
KR102756047B1 KR1020247020497A KR20247020497A KR102756047B1 KR 102756047 B1 KR102756047 B1 KR 102756047B1 KR 1020247020497 A KR1020247020497 A KR 1020247020497A KR 20247020497 A KR20247020497 A KR 20247020497A KR 102756047 B1 KR102756047 B1 KR 102756047B1
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cancer
formula
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methyl
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KR20240105481A (ko
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카비싸 넬로르
서브라만야 호사할리
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오리진 온콜로지 리미티드
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Priority claimed from US15/899,707 external-priority patent/US20180369206A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020247020497A 2017-04-24 2018-04-19 디히드로오로테이트 옥시게나제 억제제로서의 삼치환 벤조트리아졸 유도체의 사용 방법 Active KR102756047B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15/494,820 2017-04-24
US15/494,820 US9937155B2 (en) 2013-02-25 2017-04-24 Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US15/899,707 US20180369206A1 (en) 2017-04-24 2018-02-20 Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
US15/899,707 2018-02-20
KR1020197034384A KR102678263B1 (ko) 2017-04-24 2018-04-19 디히드로오로테이트 옥시게나제 억제제로서의 삼치환 벤조트리아졸 유도체의 사용 방법
PCT/IB2018/052710 WO2018197997A1 (en) 2017-04-24 2018-04-19 Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors

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KR1020197034384A Active KR102678263B1 (ko) 2017-04-24 2018-04-19 디히드로오로테이트 옥시게나제 억제제로서의 삼치환 벤조트리아졸 유도체의 사용 방법

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HRP20211462T1 (hr) 2017-04-24 2021-12-24 Aurigene Discovery Technologies Limited Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze
TWI818954B (zh) * 2018-02-20 2023-10-21 法商施維雅藥廠 三取代之苯并三唑衍生物的使用方法
ES3063941T3 (en) * 2020-08-27 2026-04-21 Servier Lab Combinations of a dhodh inhibitor and r-chop therapy for the treatment of diffuse large b-cell lymphoma, mantle cell lymphoma and burkitt lymphoma
KR102514860B1 (ko) * 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물

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JP7225114B2 (ja) 2023-02-20
NZ758333A (en) 2025-10-31
KR102678263B1 (ko) 2024-06-24
PT3615027T (pt) 2021-09-24
US12290507B2 (en) 2025-05-06
MA48459A (fr) 2020-03-04
PL3615027T3 (pl) 2022-01-03
EP3615027B1 (en) 2021-07-14
AU2018260390B2 (en) 2024-05-02
SMT202100553T1 (it) 2021-11-12
LT3615027T (lt) 2021-10-25
IL270066A (https=) 2019-12-31
UA129244C2 (uk) 2025-02-26
CN110662539B (zh) 2023-08-15
MA48459B1 (fr) 2021-09-30
MX2019012640A (es) 2020-12-11
JP2020517654A (ja) 2020-06-18
IL270066B2 (en) 2023-10-01
MD3615027T2 (ro) 2021-11-30
HRP20211462T1 (hr) 2021-12-24
RS62519B1 (sr) 2021-11-30
AU2024205090A1 (en) 2024-08-15
CN110662539A (zh) 2020-01-07
BR112019022331A2 (pt) 2020-05-26
CY1124702T1 (el) 2022-07-22
US20260097019A1 (en) 2026-04-09
JP2023022252A (ja) 2023-02-14
EA201992528A1 (ru) 2020-02-28
HUE056485T2 (hu) 2022-02-28
DK3615027T3 (da) 2021-08-30
TWI821180B (zh) 2023-11-11
EP3915557A1 (en) 2021-12-01
KR20240105481A (ko) 2024-07-05
IL270066B1 (en) 2023-06-01
ES2889100T3 (es) 2022-01-11
US20220241246A1 (en) 2022-08-04
SI3615027T1 (sl) 2021-12-31
CA3060390A1 (en) 2018-11-01
AU2018260390A1 (en) 2019-11-07
EP3615027A1 (en) 2020-03-04
PH12019502402A1 (en) 2021-01-25
TW201902880A (zh) 2019-01-16
JP2025156453A (ja) 2025-10-14
SG11201909718QA (en) 2019-11-28
KR20190140005A (ko) 2019-12-18

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