MX2019012640A - Metodos de uso de derivados de benzotriazoles trisustituidos como inhibidores de dihidroorotato-oxigenasa. - Google Patents
Metodos de uso de derivados de benzotriazoles trisustituidos como inhibidores de dihidroorotato-oxigenasa.Info
- Publication number
- MX2019012640A MX2019012640A MX2019012640A MX2019012640A MX2019012640A MX 2019012640 A MX2019012640 A MX 2019012640A MX 2019012640 A MX2019012640 A MX 2019012640A MX 2019012640 A MX2019012640 A MX 2019012640A MX 2019012640 A MX2019012640 A MX 2019012640A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- methods
- benzotriazole derivatives
- oxygenase inhibitors
- trisubstituted benzotriazole
- Prior art date
Links
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 title abstract 2
- UFIVEPVSAGBUSI-UHFFFAOYSA-N dihydroorotic acid Chemical compound OC(=O)C1CC(=O)NC(=O)N1 UFIVEPVSAGBUSI-UHFFFAOYSA-N 0.000 title 1
- 239000003650 oxygenase inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 206010027476 Metastases Diseases 0.000 abstract 1
- 102000004020 Oxygenases Human genes 0.000 abstract 1
- 108090000417 Oxygenases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona métodos para tratar un cáncer en un sujeto y para inhibir el crecimiento tumoral, metástasis o una actividad enzimática de dihidroorotatooxigenasa de un tumor o célula de cáncer. Al menos un derivado del benzotriazol trisustituido con la fórmula (I) -fórmula-se administra al sujeto o se pone en contacto con la célula de cáncer. Los compuestos de la fórmula (I) tienen sustituyentes R1, R2 y R3 que tienen los significados determinados en la especificación, y sales farmacéuticas aceptables de los mismos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/494,820 US9937155B2 (en) | 2013-02-25 | 2017-04-24 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| US15/899,707 US20180369206A1 (en) | 2017-04-24 | 2018-02-20 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| PCT/IB2018/052710 WO2018197997A1 (en) | 2017-04-24 | 2018-04-19 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019012640A true MX2019012640A (es) | 2020-12-11 |
Family
ID=65803213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019012640A MX2019012640A (es) | 2017-04-24 | 2018-04-19 | Metodos de uso de derivados de benzotriazoles trisustituidos como inhibidores de dihidroorotato-oxigenasa. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20220241246A1 (es) |
| EP (2) | EP3915557A1 (es) |
| JP (2) | JP7225114B2 (es) |
| KR (1) | KR20190140005A (es) |
| CN (1) | CN110662539B (es) |
| AU (1) | AU2018260390B2 (es) |
| BR (1) | BR112019022331A2 (es) |
| CA (1) | CA3060390A1 (es) |
| CY (1) | CY1124702T1 (es) |
| DK (1) | DK3615027T3 (es) |
| EA (1) | EA201992528A1 (es) |
| ES (1) | ES2889100T3 (es) |
| HR (1) | HRP20211462T1 (es) |
| HU (1) | HUE056485T2 (es) |
| IL (1) | IL270066B2 (es) |
| LT (1) | LT3615027T (es) |
| MA (1) | MA48459B1 (es) |
| MD (1) | MD3615027T2 (es) |
| MX (1) | MX2019012640A (es) |
| PH (1) | PH12019502402A1 (es) |
| PL (1) | PL3615027T3 (es) |
| PT (1) | PT3615027T (es) |
| RS (1) | RS62519B1 (es) |
| SG (1) | SG11201909718QA (es) |
| SI (1) | SI3615027T1 (es) |
| TW (1) | TWI821180B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020016929A8 (pt) * | 2018-02-20 | 2022-06-28 | Agios Pharmaceuticals Inc | Métodos de uso para derivados de benzotriazol trissubstituídos |
| KR102514860B1 (ko) * | 2020-12-01 | 2023-03-29 | 한국과학기술연구원 | 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494911A (en) | 1990-05-18 | 1996-02-27 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use |
| US5904937A (en) | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
| US6841561B1 (en) | 1999-10-01 | 2005-01-11 | Institute Of Molecular And Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
| ES2882797T3 (es) | 2009-04-02 | 2021-12-02 | Merck Serono Sa | Inhibidores de dihidroorotato deshidrogenasa |
| PT3019482T (pt) * | 2013-02-25 | 2018-11-28 | Aurigene Discovery Tech Ltd | Derivados de benzotriazole trissubstituídos enquanto inibidores de di-hidro-orotato-oxigenase |
-
2018
- 2018-04-19 LT LTEPPCT/IB2018/052710T patent/LT3615027T/lt unknown
- 2018-04-19 RS RS20211150A patent/RS62519B1/sr unknown
- 2018-04-19 EP EP21184786.8A patent/EP3915557A1/en active Pending
- 2018-04-19 CA CA3060390A patent/CA3060390A1/en active Pending
- 2018-04-19 KR KR1020197034384A patent/KR20190140005A/ko active IP Right Grant
- 2018-04-19 HU HUE18723602A patent/HUE056485T2/hu unknown
- 2018-04-19 EP EP18723602.1A patent/EP3615027B1/en active Active
- 2018-04-19 SI SI201830423T patent/SI3615027T1/sl unknown
- 2018-04-19 HR HRP20211462TT patent/HRP20211462T1/hr unknown
- 2018-04-19 ES ES18723602T patent/ES2889100T3/es active Active
- 2018-04-19 IL IL270066A patent/IL270066B2/en unknown
- 2018-04-19 PL PL18723602T patent/PL3615027T3/pl unknown
- 2018-04-19 MX MX2019012640A patent/MX2019012640A/es unknown
- 2018-04-19 JP JP2019557358A patent/JP7225114B2/ja active Active
- 2018-04-19 AU AU2018260390A patent/AU2018260390B2/en active Active
- 2018-04-19 PT PT187236021T patent/PT3615027T/pt unknown
- 2018-04-19 CN CN201880027155.0A patent/CN110662539B/zh active Active
- 2018-04-19 BR BR112019022331-2A patent/BR112019022331A2/pt unknown
- 2018-04-19 DK DK18723602.1T patent/DK3615027T3/da active
- 2018-04-19 SG SG11201909718Q patent/SG11201909718QA/en unknown
- 2018-04-19 MD MDE20200226T patent/MD3615027T2/ro unknown
- 2018-04-19 MA MA48459A patent/MA48459B1/fr unknown
- 2018-04-19 EA EA201992528A patent/EA201992528A1/ru unknown
- 2018-04-23 TW TW107113690A patent/TWI821180B/zh active
-
2019
- 2019-10-23 PH PH12019502402A patent/PH12019502402A1/en unknown
-
2021
- 2021-10-04 CY CY20211100855T patent/CY1124702T1/el unknown
- 2021-10-14 US US17/501,701 patent/US20220241246A1/en active Pending
-
2022
- 2022-12-02 JP JP2022193406A patent/JP2023022252A/ja active Pending
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