KR102744193B1 - 그룹 a 스트렙토코쿠스 백신 - Google Patents

그룹 a 스트렙토코쿠스 백신 Download PDF

Info

Publication number
KR102744193B1
KR102744193B1 KR1020237007349A KR20237007349A KR102744193B1 KR 102744193 B1 KR102744193 B1 KR 102744193B1 KR 1020237007349 A KR1020237007349 A KR 1020237007349A KR 20237007349 A KR20237007349 A KR 20237007349A KR 102744193 B1 KR102744193 B1 KR 102744193B1
Authority
KR
South Korea
Prior art keywords
amino acid
acid sequence
seq
protein
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020237007349A
Other languages
English (en)
Korean (ko)
Other versions
KR20230039751A (ko
Inventor
마니샤 판데이
마이클 배츠로프
마이클 굿
Original Assignee
그리피스 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2014901382A external-priority patent/AU2014901382A0/en
Application filed by 그리피스 유니버시티 filed Critical 그리피스 유니버시티
Publication of KR20230039751A publication Critical patent/KR20230039751A/ko
Application granted granted Critical
Publication of KR102744193B1 publication Critical patent/KR102744193B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1275—Streptococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020237007349A 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신 Active KR102744193B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AU2014901382A AU2014901382A0 (en) 2014-04-15 Group a streptococcal vaccine
AU2014901382 2014-04-15
AU2014903042A AU2014903042A0 (en) 2014-08-06 Group a streptococcal vaccine
AU2014903042 2014-08-06
AU2014904453A AU2014904453A0 (en) 2014-11-05 Group a streptococcal vaccine
AU2014904453 2014-11-05
KR1020167031477A KR102730367B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신
PCT/AU2015/050174 WO2015157820A1 (en) 2014-04-15 2015-04-15 Group a streptococcus vaccine

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167031477A Division KR102730367B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Publications (2)

Publication Number Publication Date
KR20230039751A KR20230039751A (ko) 2023-03-21
KR102744193B1 true KR102744193B1 (ko) 2024-12-19

Family

ID=54323282

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237007349A Active KR102744193B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신
KR1020167031477A Active KR102730367B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020167031477A Active KR102730367B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Country Status (16)

Country Link
US (2) US10301362B2 (cg-RX-API-DMAC10.html)
EP (1) EP3131575B1 (cg-RX-API-DMAC10.html)
JP (2) JP2017513849A (cg-RX-API-DMAC10.html)
KR (2) KR102744193B1 (cg-RX-API-DMAC10.html)
CN (1) CN106794236B (cg-RX-API-DMAC10.html)
AU (1) AU2015246654B2 (cg-RX-API-DMAC10.html)
BR (1) BR112016023915B1 (cg-RX-API-DMAC10.html)
CA (1) CA2945052C (cg-RX-API-DMAC10.html)
DK (1) DK3131575T3 (cg-RX-API-DMAC10.html)
IL (1) IL248266B (cg-RX-API-DMAC10.html)
MX (1) MX392514B (cg-RX-API-DMAC10.html)
MY (1) MY191217A (cg-RX-API-DMAC10.html)
NZ (1) NZ725212A (cg-RX-API-DMAC10.html)
SG (1) SG11201608380PA (cg-RX-API-DMAC10.html)
WO (1) WO2015157820A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201607355B (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3131575B1 (en) 2014-04-15 2024-05-08 Griffith University Group a streptococcus vaccine
CN106606775A (zh) * 2015-10-27 2017-05-03 格里菲斯大学 脂质体a群链球菌疫苗
TWI598360B (zh) * 2016-12-19 2017-09-11 義守大學 Ｆｓｂｍ重組蛋白及其用途
WO2019036761A1 (en) * 2017-08-23 2019-02-28 Griffith University IMMUNOGENIC PEPTIDE DIRECTED AGAINST GROUP A STREPTOCOCCUS
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
KR102437436B1 (ko) * 2019-04-26 2022-08-30 주식회사 엠디헬스케어 스트렙토코커스 파이오제네스 세균 유래 단백질 및 이의 용도
NL2023863B1 (en) 2019-09-20 2021-05-25 Univ Griffith Protein particles and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047238A (en) 1983-06-15 1991-09-10 American Home Products Corporation Adjuvants for vaccines
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5811105A (en) 1987-12-23 1998-09-22 Glaxo Wellcome, Inc. Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
US5785973A (en) 1988-02-01 1998-07-28 Praxis Biologics, Inc. Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
GB8912330D0 (en) 1989-05-30 1989-07-12 Wellcome Found Live vaccines
GB9007194D0 (en) 1990-03-30 1990-05-30 Wellcome Found Live vaccines
AUPM885194A0 (en) * 1994-10-14 1994-11-10 Council Of The Queensland Institute Of Medical Research, The Synthetic peptides and vaccines comprising same
AUPO007396A0 (en) 1996-05-24 1996-06-20 Csl Limited Ebv ctl epitopes
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
EP1807446A2 (en) * 2004-10-08 2007-07-18 Novartis Vaccines and Diagnostics, Inc. Immunogenic and therapeutic compositions for streptococcus pyogenes
WO2006121656A2 (en) * 2005-05-05 2006-11-16 Merck & Co., Inc. Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease
EP1962961B1 (en) 2005-11-29 2013-01-09 The University Of Sydney Demibodies: dimerisation-activated therapeutic agents
EP2292647A3 (en) * 2006-07-07 2011-06-08 Intercell AG Small Streptococcus pyogenes antigens and their use
US20090010929A1 (en) 2006-12-04 2009-01-08 Good Michael F Therapeutic Antibodies, Antibody Fragments and Antibody Conjugates
US8482298B2 (en) 2006-12-18 2013-07-09 Schrader Electronics Ltd. Liquid level and composition sensing systems and methods using EMF wave propagation
US8287885B2 (en) * 2007-09-12 2012-10-16 Novartis Ag GAS57 mutant antigens and GAS57 antibodies
US20090162369A1 (en) * 2007-12-12 2009-06-25 Katin Helena Threse Nordstrom Synthetic chimeric peptides
HRP20160306T1 (hr) * 2008-09-17 2016-04-22 Glaxosmithkline Biologicals S.A. Kombinacija cjepiva i terapijskih sredstava protiv gas
EP3131575B1 (en) 2014-04-15 2024-05-08 Griffith University Group a streptococcus vaccine
WO2019036761A1 (en) * 2017-08-23 2019-02-28 Griffith University IMMUNOGENIC PEPTIDE DIRECTED AGAINST GROUP A STREPTOCOCCUS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Immunol Cell Biol. 80(2):178-87 (2002.4)
vaccine, 27, 4923-4929 (2009)

Also Published As

Publication number Publication date
CA2945052A1 (en) 2015-10-22
EP3131575A4 (en) 2017-11-01
US20190256562A1 (en) 2019-08-22
EP3131575A1 (en) 2017-02-22
EP3131575B1 (en) 2024-05-08
SG11201608380PA (en) 2016-11-29
AU2015246654B2 (en) 2019-08-08
JP2017513849A (ja) 2017-06-01
JP2021042247A (ja) 2021-03-18
CA2945052C (en) 2023-05-02
ZA201607355B (en) 2019-03-27
MX392514B (es) 2025-03-24
WO2015157820A1 (en) 2015-10-22
IL248266B (en) 2021-09-30
IL248266A0 (en) 2016-11-30
KR20160144455A (ko) 2016-12-16
DK3131575T3 (da) 2024-05-21
BR112016023915A2 (pt) 2017-10-17
NZ725212A (en) 2023-04-28
US20170037087A1 (en) 2017-02-09
BR112016023915B1 (pt) 2024-03-12
KR102730367B1 (ko) 2024-11-15
MY191217A (en) 2022-06-09
CN106794236B (zh) 2021-09-03
AU2015246654A1 (en) 2016-11-03
JP7072921B2 (ja) 2022-05-23
US10301362B2 (en) 2019-05-28
MX2016013277A (es) 2017-01-18
CN106794236A (zh) 2017-05-31
US10513544B2 (en) 2019-12-24
KR20230039751A (ko) 2023-03-21

Similar Documents

Publication Publication Date Title
US10513544B2 (en) Group A streptococcus vaccine
JP2023025066A (ja) ワクチン構築物およびブドウ球菌感染症に対するその使用
US12383630B2 (en) Immunogenic peptide against group a Streptococcus
WO2017070735A1 (en) Liposomal vaccine
KR20210010882A (ko) 연쇄구균 독성 쇼크 증후군
RU2775621C2 (ru) Иммуногенный пептид против стрептококков группы а
HK1238144A1 (en) Group a streptococcus vaccine
HK1238144B (en) Group a streptococcus vaccine
WO2023081861A9 (en) Enhanced expression via autotransporters
US20180243392A1 (en) Cs21 and lnga protein vaccines

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20230228

Application number text: 1020167031477

Filing date: 20161110

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20231123

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20241024

PG1601 Publication of registration