KR102738936B1 - 골수증식 장애의 치료 방법 - Google Patents

골수증식 장애의 치료 방법 Download PDF

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Publication number
KR102738936B1
KR102738936B1 KR1020217019508A KR20217019508A KR102738936B1 KR 102738936 B1 KR102738936 B1 KR 102738936B1 KR 1020217019508 A KR1020217019508 A KR 1020217019508A KR 20217019508 A KR20217019508 A KR 20217019508A KR 102738936 B1 KR102738936 B1 KR 102738936B1
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pharmaceutical composition
composition according
ruxolitinib
compound
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Korean (ko)
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KR20210095904A (ko
Inventor
아드리안 센더로비츠
마이클 쿠퍼
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콘스텔레이션 파마슈티칼스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020217019508A 2018-11-27 2018-11-27 골수증식 장애의 치료 방법 Active KR102738936B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247040010A KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2018/062534 WO2020112086A1 (en) 2018-11-27 2018-11-27 Methods of treating myeloproliferative disorders

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KR1020247040010A Division KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

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KR20210095904A KR20210095904A (ko) 2021-08-03
KR102738936B1 true KR102738936B1 (ko) 2024-12-06

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KR1020217019508A Active KR102738936B1 (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법
KR1020247040010A Pending KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

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KR1020247040010A Pending KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

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JP (2) JP7453230B2 (enExample)
KR (2) KR102738936B1 (enExample)
AU (1) AU2018451360B2 (enExample)
BR (1) BR112021010134A2 (enExample)
CA (1) CA3120973A1 (enExample)
EA (1) EA202191489A1 (enExample)
SG (1) SG11202105279SA (enExample)
WO (1) WO2020112086A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021006205A (es) 2018-11-27 2021-10-13 Constellation Pharmaceuticals Inc Metodos de tratamiento de trastornos mieloproliferativos.
KR20220088699A (ko) 2019-09-27 2022-06-28 디스크 메디슨, 인크. 골수섬유증 및 관련 상태의 치료 방법
JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
EP4192470A1 (en) * 2020-08-04 2023-06-14 Constellation Pharmaceuticals, Inc. 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide for treating thrombocythemia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
SI3157928T1 (sl) 2014-06-20 2019-06-28 Constellation Pharmaceuticals, Inc. Kristalinične oblike 2-((4S)-6-(4-klorofenil)-1-metil-4H-benzo(C)izoksazolo(4,5-E)azepin-4-il acetamida

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer cell, 2018, 33(1), 29-43*
Journal of Medicinal Chemistry, 2016, 59, 1330-1339*

Also Published As

Publication number Publication date
KR20210095904A (ko) 2021-08-03
WO2020112086A1 (en) 2020-06-04
SG11202105279SA (en) 2021-06-29
CA3120973A1 (en) 2020-06-04
JP7453230B2 (ja) 2024-03-19
KR20250004357A (ko) 2025-01-07
EA202191489A1 (ru) 2021-09-10
JP2024063214A (ja) 2024-05-10
JP2022519425A (ja) 2022-03-24
AU2018451360A1 (en) 2021-06-10
BR112021010134A2 (pt) 2021-08-24
AU2018451360B2 (en) 2022-05-26

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