KR102718333B1 - Arg1 및/또는 arg2의 억제제 - Google Patents

Arg1 및/또는 arg2의 억제제 Download PDF

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KR102718333B1
KR102718333B1 KR1020217018476A KR20217018476A KR102718333B1 KR 102718333 B1 KR102718333 B1 KR 102718333B1 KR 1020217018476 A KR1020217018476 A KR 1020217018476A KR 20217018476 A KR20217018476 A KR 20217018476A KR 102718333 B1 KR102718333 B1 KR 102718333B1
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KR20210108954A (ko
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조엘 비티
코린 니콜 폴리
레베카 루이스 그레인지
테즈칸 구네이
스티븐 도널드 제이콥
야로슬라프 칼리시아크
만모한 레디 렐레티
에릭 앨런 린지
데바시스 만달
에릭 토마스 뉴컴
제이 패트릭 파워스
브랜든 레이드 로젠
용리 수
안 투 트란
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아르커스 바이오사이언시즈 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217018476A 2018-11-16 2019-11-15 Arg1 및/또는 arg2의 억제제 Active KR102718333B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768284P 2018-11-16 2018-11-16
US62/768,284 2018-11-16
PCT/US2019/061657 WO2020102646A2 (en) 2018-11-16 2019-11-15 Inhibitors of arg1 and/or arg2

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KR20210108954A KR20210108954A (ko) 2021-09-03
KR102718333B1 true KR102718333B1 (ko) 2024-10-17

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US (1) US12226425B2 (https=)
EP (1) EP3880685B1 (https=)
JP (1) JP7461350B2 (https=)
KR (1) KR102718333B1 (https=)
CN (1) CN113382998A (https=)
AR (1) AR117102A1 (https=)
AU (1) AU2019379808C1 (https=)
CA (1) CA3120196A1 (https=)
ES (1) ES3034676T3 (https=)
TW (1) TWI828800B (https=)
UY (1) UY38476A (https=)
WO (1) WO2020102646A2 (https=)

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TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
WO2022246179A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl inhibitor compounds
EP4341261A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
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US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
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Publication number Publication date
EP3880685A2 (en) 2021-09-22
JP7461350B2 (ja) 2024-04-03
KR20210108954A (ko) 2021-09-03
EP3880685C0 (en) 2025-06-18
CN113382998A (zh) 2021-09-10
EP3880685B1 (en) 2025-06-18
UY38476A (es) 2020-06-30
ES3034676T3 (en) 2025-08-21
TW202033203A (zh) 2020-09-16
US20220016143A1 (en) 2022-01-20
EP3880685A4 (en) 2022-07-27
AU2019379808C1 (en) 2024-01-25
CA3120196A1 (en) 2020-05-22
US12226425B2 (en) 2025-02-18
JP2022507474A (ja) 2022-01-18
WO2020102646A2 (en) 2020-05-22
AU2019379808B2 (en) 2023-08-03
TWI828800B (zh) 2024-01-11
WO2020102646A3 (en) 2020-08-13
AR117102A1 (es) 2021-07-14
AU2019379808A1 (en) 2021-06-24

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