AU2019379808C1 - Inhibitors of ARG1 and/or ARG2 - Google Patents

Inhibitors of ARG1 and/or ARG2 Download PDF

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Publication number
AU2019379808C1
AU2019379808C1 AU2019379808A AU2019379808A AU2019379808C1 AU 2019379808 C1 AU2019379808 C1 AU 2019379808C1 AU 2019379808 A AU2019379808 A AU 2019379808A AU 2019379808 A AU2019379808 A AU 2019379808A AU 2019379808 C1 AU2019379808 C1 AU 2019379808C1
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AU
Australia
Prior art keywords
mehnch
mehn
pharmaceutically acceptable
compound
cancer
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Active
Application number
AU2019379808A
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English (en)
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AU2019379808B2 (en
AU2019379808A1 (en
Inventor
Joel BEATTY
Corinne Nicole FOLEY
Rebecca Louise Grange
Tezcan GUNEY
Steven Donald JACOB
Jaroslaw Kalisiak
Manmohan Reddy Leleti
Erick Allen Lindsey
Debashis MANDAL
Eric Thomas NEWCOMB
Jay Patrick POWERS
Brandon Reid ROSEN
Yongli Su
Anh Thu TRAN
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Arcus Biosciences Inc
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Arcus Biosciences Inc
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Publication date
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Publication of AU2019379808A1 publication Critical patent/AU2019379808A1/en
Application granted granted Critical
Publication of AU2019379808B2 publication Critical patent/AU2019379808B2/en
Publication of AU2019379808C1 publication Critical patent/AU2019379808C1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019379808A 2018-11-16 2019-11-15 Inhibitors of ARG1 and/or ARG2 Active AU2019379808C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768284P 2018-11-16 2018-11-16
US62/768,284 2018-11-16
PCT/US2019/061657 WO2020102646A2 (en) 2018-11-16 2019-11-15 Inhibitors of arg1 and/or arg2

Publications (3)

Publication Number Publication Date
AU2019379808A1 AU2019379808A1 (en) 2021-06-24
AU2019379808B2 AU2019379808B2 (en) 2023-08-03
AU2019379808C1 true AU2019379808C1 (en) 2024-01-25

Family

ID=70731928

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019379808A Active AU2019379808C1 (en) 2018-11-16 2019-11-15 Inhibitors of ARG1 and/or ARG2

Country Status (12)

Country Link
US (1) US12226425B2 (https=)
EP (1) EP3880685B1 (https=)
JP (1) JP7461350B2 (https=)
KR (1) KR102718333B1 (https=)
CN (1) CN113382998A (https=)
AR (1) AR117102A1 (https=)
AU (1) AU2019379808C1 (https=)
CA (1) CA3120196A1 (https=)
ES (1) ES3034676T3 (https=)
TW (1) TWI828800B (https=)
UY (1) UY38476A (https=)
WO (1) WO2020102646A2 (https=)

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CN119118872A (zh) 2020-03-19 2024-12-13 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
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TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
WO2022246179A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl inhibitor compounds
EP4341261A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
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CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US20260116868A1 (en) 2023-10-06 2026-04-30 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
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Also Published As

Publication number Publication date
EP3880685A2 (en) 2021-09-22
JP7461350B2 (ja) 2024-04-03
KR20210108954A (ko) 2021-09-03
EP3880685C0 (en) 2025-06-18
CN113382998A (zh) 2021-09-10
EP3880685B1 (en) 2025-06-18
UY38476A (es) 2020-06-30
ES3034676T3 (en) 2025-08-21
TW202033203A (zh) 2020-09-16
US20220016143A1 (en) 2022-01-20
EP3880685A4 (en) 2022-07-27
KR102718333B1 (ko) 2024-10-17
CA3120196A1 (en) 2020-05-22
US12226425B2 (en) 2025-02-18
JP2022507474A (ja) 2022-01-18
WO2020102646A2 (en) 2020-05-22
AU2019379808B2 (en) 2023-08-03
TWI828800B (zh) 2024-01-11
WO2020102646A3 (en) 2020-08-13
AR117102A1 (es) 2021-07-14
AU2019379808A1 (en) 2021-06-24

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