KR102695627B1 - 빌라스틴, 베타-시클로덱스트린 및 적어도 하나의 겔화제를 포함하는 안과용 조성물 - Google Patents

빌라스틴, 베타-시클로덱스트린 및 적어도 하나의 겔화제를 포함하는 안과용 조성물 Download PDF

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KR102695627B1
KR102695627B1 KR1020207023573A KR20207023573A KR102695627B1 KR 102695627 B1 KR102695627 B1 KR 102695627B1 KR 1020207023573 A KR1020207023573 A KR 1020207023573A KR 20207023573 A KR20207023573 A KR 20207023573A KR 102695627 B1 KR102695627 B1 KR 102695627B1
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cyclodextrin
pharmaceutical composition
ophthalmic pharmaceutical
bilastine
pharmaceutically acceptable
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KR20200111727A (ko
Inventor
곤잘로 에르난데스 에레로
고로스티자 애나 곤잘로
파블로 모란 폴라두라
아르투로 재즈페 아르체
니에베스 페르난데스 에르난도
타니아 곤잘레스 가르시아
팔로마 타토 세르데이라
프란시스코 하비에르 오테로 에스피나르
안소 페르난데스 페레이로
빅토리아 디아즈 톰
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파에스 파마, 에스.에이.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207023573A 2018-01-18 2019-01-09 빌라스틴, 베타-시클로덱스트린 및 적어도 하나의 겔화제를 포함하는 안과용 조성물 Active KR102695627B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18382021 2018-01-18
EP18382021.6 2018-01-18
PCT/EP2019/050433 WO2019141563A1 (en) 2018-01-18 2019-01-09 Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent

Publications (2)

Publication Number Publication Date
KR20200111727A KR20200111727A (ko) 2020-09-29
KR102695627B1 true KR102695627B1 (ko) 2024-08-16

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Country Status (28)

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US (2) US20210128544A1 (cg-RX-API-DMAC7.html)
EP (2) EP3740191B1 (cg-RX-API-DMAC7.html)
JP (1) JP7309729B2 (cg-RX-API-DMAC7.html)
KR (1) KR102695627B1 (cg-RX-API-DMAC7.html)
CN (1) CN111727035B (cg-RX-API-DMAC7.html)
AR (1) AR114216A1 (cg-RX-API-DMAC7.html)
AU (1) AU2019209214B2 (cg-RX-API-DMAC7.html)
CA (1) CA3088740A1 (cg-RX-API-DMAC7.html)
CL (1) CL2020001895A1 (cg-RX-API-DMAC7.html)
CO (1) CO2020009992A2 (cg-RX-API-DMAC7.html)
CY (1) CY1124270T1 (cg-RX-API-DMAC7.html)
DK (1) DK3740191T3 (cg-RX-API-DMAC7.html)
EA (1) EA202091725A1 (cg-RX-API-DMAC7.html)
ES (1) ES2878107T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20211037T1 (cg-RX-API-DMAC7.html)
HU (1) HUE054594T2 (cg-RX-API-DMAC7.html)
LT (1) LT3740191T (cg-RX-API-DMAC7.html)
MA (1) MA51612B1 (cg-RX-API-DMAC7.html)
MX (1) MX2020007692A (cg-RX-API-DMAC7.html)
PL (1) PL3740191T3 (cg-RX-API-DMAC7.html)
PT (1) PT3740191T (cg-RX-API-DMAC7.html)
PY (1) PY1903392A (cg-RX-API-DMAC7.html)
SA (1) SA520412443B1 (cg-RX-API-DMAC7.html)
SI (1) SI3740191T1 (cg-RX-API-DMAC7.html)
TW (1) TWI833727B (cg-RX-API-DMAC7.html)
UY (1) UY38055A (cg-RX-API-DMAC7.html)
WO (1) WO2019141563A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA202005077B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025508704A (ja) * 2022-02-17 2025-04-10 ファエス・ファルマ・ソシエダッド・アノニマ １日１回非経口投与のためのビラスチン組成物
CN116211795B (zh) * 2022-12-26 2025-09-26 深圳市贝美药业有限公司 一种比拉斯汀口服液体制剂及其制备方法
CN115970066B (zh) * 2022-12-29 2024-09-27 成都爱睿康乐医疗器械有限公司 基于主客体相互作用的载药纳米凝胶生物润滑剂及其制备方法和应用
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024256956A1 (en) * 2023-06-13 2024-12-19 Leiutis Pharmaceuticals Llp Stable formulations of bilastine for nasal and ophthalmic use

Citations (1)

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CN103784462A (zh) * 2014-02-25 2014-05-14 宋俊智 包含比拉斯汀及甾族化合物的药物制剂

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TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
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DE10161149B4 (de) * 2001-12-12 2007-03-08 Ursapharm Arzneimittel Gmbh & Co. Kg Verwendung von Heparin-haltigem Ophthalmikum
CA2484460C (en) 2002-04-19 2009-09-29 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-.alpha..alpha. dimethyl-benzeneacetic acid
US20050239745A1 (en) * 2004-03-03 2005-10-27 Ophthalmic Research Associates, Inc. Novel topical ophthalmic formulations
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WO2007047253A2 (en) 2005-10-11 2007-04-26 Eastman Chemical Company Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
UA94938C2 (ru) * 2006-03-31 2011-06-25 ВИСТЕКОН ФАРМАСЬЮТИКАЛС, ЭлЭлСи Офтальмическая композиция для лечения клинических симптомов глазной аллергии, которая содержит алкафтадин или его производное (варианты)
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JP2012520880A (ja) * 2009-03-17 2012-09-10 アーシエックス セラピューティックス， インコーポレイテッド ケトチフェンの眼科用製剤および使用方法
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ZA202005077B (en) 2024-12-18
CA3088740A1 (en) 2019-07-25
EP3740191B1 (en) 2021-04-28
HRP20211037T1 (hr) 2021-10-01
AU2019209214A1 (en) 2020-08-13
DK3740191T3 (da) 2021-06-07
PL3740191T3 (pl) 2021-11-29
CN111727035B (zh) 2024-05-28
BR112020014265A2 (pt) 2020-12-08
CY1124270T1 (el) 2022-07-22
MA51612A (fr) 2020-11-25
AU2019209214B2 (en) 2023-11-23
UY38055A (es) 2019-08-30
KR20200111727A (ko) 2020-09-29
PT3740191T (pt) 2021-07-09
MA51612B1 (fr) 2021-06-30
ES2878107T3 (es) 2021-11-18
MX2020007692A (es) 2020-09-14
CO2020009992A2 (es) 2021-01-18
HUE054594T2 (hu) 2021-09-28
WO2019141563A1 (en) 2019-07-25
PY1903392A (es) 2019-08-01
JP7309729B2 (ja) 2023-07-18
TWI833727B (zh) 2024-03-01
LT3740191T (lt) 2021-08-10
JP2021511317A (ja) 2021-05-06
SI3740191T1 (sl) 2021-09-30
AR114216A1 (es) 2020-08-05
SA520412443B1 (ar) 2022-09-01
EP3740191A1 (en) 2020-11-25
EA202091725A1 (ru) 2020-10-12
TW201932110A (zh) 2019-08-16
US20260027099A1 (en) 2026-01-29
CL2020001895A1 (es) 2020-12-04
EP3915539A1 (en) 2021-12-01
CN111727035A (zh) 2020-09-29
US20210128544A1 (en) 2021-05-06

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