KR102651947B1 - Tlr7/8/9의 억제제로서 유용한 치환된 인돌 화합물 - Google Patents

Tlr7/8/9의 억제제로서 유용한 치환된 인돌 화합물 Download PDF

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KR102651947B1
KR102651947B1 KR1020207005967A KR20207005967A KR102651947B1 KR 102651947 B1 KR102651947 B1 KR 102651947B1 KR 1020207005967 A KR1020207005967 A KR 1020207005967A KR 20207005967 A KR20207005967 A KR 20207005967A KR 102651947 B1 KR102651947 B1 KR 102651947B1
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isopropyl
indol
piperidin
methyl
dimethylpyridin
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KR20200036005A (ko
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알라릭 제이. 딕맨
담펄 에스. 도드
타시르 샴술 하크
브라이언 케이. 화이틀리
존 엘. 길모어
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207005967A 2017-08-04 2018-08-03 Tlr7/8/9의 억제제로서 유용한 치환된 인돌 화합물 Active KR102651947B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541335P 2017-08-04 2017-08-04
US62/541,335 2017-08-04
PCT/US2018/045082 WO2019028302A1 (en) 2017-08-04 2018-08-03 SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR7 / 8/9 INHIBITORS

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KR20200036005A KR20200036005A (ko) 2020-04-06
KR102651947B1 true KR102651947B1 (ko) 2024-03-26

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KR1020207005967A Active KR102651947B1 (ko) 2017-08-04 2018-08-03 Tlr7/8/9의 억제제로서 유용한 치환된 인돌 화합물

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US (1) US11447466B2 (enExample)
EP (1) EP3661926B1 (enExample)
JP (1) JP7104775B2 (enExample)
KR (1) KR102651947B1 (enExample)
CN (1) CN110997656B (enExample)
ES (1) ES2909401T3 (enExample)
WO (1) WO2019028302A1 (enExample)

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JP7434186B2 (ja) 2018-06-12 2024-02-20 エフ． ホフマン－ラ ロシュ アーゲー 自己免疫疾患の処置のための新規のヘテロアリールヘテロシクリル化合物
CN112584903B (zh) 2018-07-23 2025-12-23 豪夫迈·罗氏有限公司 用于自身免疫性疾病治疗的哌嗪化合物
CN112638908A (zh) 2018-09-04 2021-04-09 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的苯并噻唑类化合物
WO2020048596A1 (en) 2018-09-06 2020-03-12 F. Hoffmann-La Roche Ag Novel pyrazolopyridine compounds for the treatment of autoimmune disease
CN112654618A (zh) 2018-09-06 2021-04-13 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的新型环脒化合物
EP4051387B1 (en) 2019-10-31 2025-02-19 F. Hoffmann-La Roche AG Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease
WO2021099284A1 (en) 2019-11-19 2021-05-27 F. Hoffmann-La Roche Ag Hydro-1h-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease
US12421252B2 (en) 2019-11-20 2025-09-23 Hoffmann-La Roche Inc. Spiro (isobenzofuranazetidine) compounds for the treatment of autoimmune disease
CN111747926B (zh) * 2020-06-23 2024-01-30 浙江华海药业股份有限公司 一种羟哌吡酮游离碱的合成工艺改进方法
KR20230053644A (ko) 2020-08-19 2023-04-21 브리스톨-마이어스 스큅 컴퍼니 섬유증의 치료를 위한 tlr9 억제제로서의 이미다조[1,2-a]피리딘 및 [1,2,4]트리아졸로[1,5-a]피리딘 유도체
CA3189873A1 (en) 2020-08-19 2022-02-24 David S. Yoon 1h-benzo[d]imidazole derivatives as tlr9 inhibitors for the treatment of fibrosis
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
TWI861488B (zh) 2021-04-16 2024-11-11 美商基利科學股份有限公司 噻吩并吡咯化合物
CN113604553B (zh) * 2021-07-27 2023-08-15 中南大学湘雅二医院 成人still’s病生物标志物、诊断试剂及其应用
AU2022341114A1 (en) 2021-09-10 2024-02-29 Gilead Sciences, Inc. Thienopyrrole compounds
CN114591339B (zh) * 2022-05-10 2022-08-02 上海维申医药有限公司 一类Toll样受体抑制剂及其制备和应用

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WO2018049089A1 (en) 2016-09-09 2018-03-15 Bristol-Myers Squibb Company Pyridyl substituted indole compounds
US20210087174A1 (en) 2017-12-20 2021-03-25 Bristol-Myers Squibb Company Aryl and heteroaryl substituted indole compounds

Also Published As

Publication number Publication date
WO2019028302A1 (en) 2019-02-07
KR20200036005A (ko) 2020-04-06
ES2909401T3 (es) 2022-05-06
JP2020529433A (ja) 2020-10-08
JP7104775B2 (ja) 2022-07-21
EP3661926B1 (en) 2022-02-23
CN110997656A (zh) 2020-04-10
EP3661926A1 (en) 2020-06-10
CN110997656B (zh) 2023-04-14
US20200239437A1 (en) 2020-07-30
US11447466B2 (en) 2022-09-20

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