KR102620681B1 - 정신분열증을 치료하기 위한 2-((1-(2-(4-플루오로페닐)-2-옥소에틸)피페리딘-4-일)메틸)이소인돌린-1-온을 포함하는 조성물 - Google Patents

정신분열증을 치료하기 위한 2-((1-(2-(4-플루오로페닐)-2-옥소에틸)피페리딘-4-일)메틸)이소인돌린-1-온을 포함하는 조성물 Download PDF

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KR102620681B1
KR102620681B1 KR1020177018088A KR20177018088A KR102620681B1 KR 102620681 B1 KR102620681 B1 KR 102620681B1 KR 1020177018088 A KR1020177018088 A KR 1020177018088A KR 20177018088 A KR20177018088 A KR 20177018088A KR 102620681 B1 KR102620681 B1 KR 102620681B1
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레미 루트링거
마사히로 오쿠야마
나딘 노엘
산드라 베르너
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미쓰비시 타나베 파마 코퍼레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020177018088A 2014-12-02 2015-11-30 정신분열증을 치료하기 위한 2-((1-(2-(4-플루오로페닐)-2-옥소에틸)피페리딘-4-일)메틸)이소인돌린-1-온을 포함하는 조성물 Active KR102620681B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086691P 2014-12-02 2014-12-02
US62/086,691 2014-12-02
US201562248071P 2015-10-29 2015-10-29
US62/248,071 2015-10-29
PCT/US2015/062985 WO2016089766A1 (en) 2014-12-02 2015-11-30 Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

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KR20170106310A KR20170106310A (ko) 2017-09-20
KR102620681B1 true KR102620681B1 (ko) 2024-01-04

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US (7) US9458130B2 (https=)
EP (2) EP3227273B1 (https=)
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KR (1) KR102620681B1 (https=)
CN (2) CN107567444A (https=)
AU (4) AU2015355226B2 (https=)
BR (1) BR112017011555B1 (https=)
CA (1) CA2968977A1 (https=)
CL (2) CL2017001376A1 (https=)
CO (1) CO2017005498A2 (https=)
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EA (1) EA201791226A1 (https=)
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IL (4) IL280052B2 (https=)
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PE (1) PE20171646A1 (https=)
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TW (1) TWI694069B (https=)
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WO (1) WO2016089766A1 (https=)
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IL308650B2 (en) * 2017-06-21 2025-08-01 Minerva Neurosciences Inc Gastro-resistant controlled release oral dosage forms
JP7811085B2 (ja) 2017-09-01 2026-02-04 ピーティーシー セラピューティクス エムピー，インコーポレイテッド セピアプテリンを含む医薬組成物及びその使用
CN107721988A (zh) * 2017-10-31 2018-02-23 无锡福祈制药有限公司 具有抗炎活性的异吲哚‑1‑酮类化合物
KR102886241B1 (ko) * 2018-08-21 2025-11-14 미쓰비시 타나베 파마 코퍼레이션 음성 증상 및 장애를 치료하고, 신경가소성을 증가시키고, 신경보호를 촉진시키기 위한 롤루페리돈의 용도
TWI841545B (zh) * 2018-12-12 2024-05-11 日商田邊三菱製藥股份有限公司 耐胃性控制釋放經口劑型
EP3990113A1 (en) 2019-06-28 2022-05-04 Teva Czech Industries s.r.o. Solid state forms of roluperidone and salts thereof
IL298323B2 (en) 2020-05-20 2023-10-01 Univ Illinois A method for treating lysosomal storage disease using histatin peptides
CN116251078B (zh) * 2021-12-09 2025-12-19 河北以岭医药研究院有限公司 一种盐酸度洛西汀肠溶胶囊及其制备方法
JP2025505261A (ja) 2022-02-14 2025-02-21 ミネルヴァ ニューロサイエンシズ，インコーポレーテッド 統合失調症患者における再発の予防におけるロルペリドンの使用
WO2025090588A1 (en) 2023-10-24 2025-05-01 Minerva Neurosciences, Inc. Roluperidone for the treatment of lysosomal storage disorders and their symptoms

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IL308650B2 (en) 2017-06-21 2025-08-01 Minerva Neurosciences Inc Gastro-resistant controlled release oral dosage forms
KR102886241B1 (ko) 2018-08-21 2025-11-14 미쓰비시 타나베 파마 코퍼레이션 음성 증상 및 장애를 치료하고, 신경가소성을 증가시키고, 신경보호를 촉진시키기 위한 롤루페리돈의 용도

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US20030212094A1 (en) 2000-02-29 2003-11-13 Haruko Yamabe Novel cyclic amide derivatives
US20100055133A1 (en) 2008-08-12 2010-03-04 Biovail Laboratories International (Barbados) S.R.L Pharmaceutical compositions
WO2015191554A1 (en) 2014-06-09 2015-12-17 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia

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EP4063357A1 (en) 2022-09-28
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CO2017005498A2 (es) 2017-09-20
JP2022105159A (ja) 2022-07-12
EP3227273B1 (en) 2022-02-09
PT3227273T (pt) 2022-04-06
AU2015355226B2 (en) 2020-04-02
KR20170106310A (ko) 2017-09-20
US20230201184A1 (en) 2023-06-29
NZ732033A (en) 2023-10-27
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US20160152597A1 (en) 2016-06-02
JP2025004090A (ja) 2025-01-14
BR112017011555B1 (pt) 2023-10-03
IL301320B2 (en) 2024-11-01
AU2020204286A1 (en) 2020-07-16
US20200022968A1 (en) 2020-01-23
CN111110677A (zh) 2020-05-08
IL313572A (en) 2024-08-01
US20210228561A1 (en) 2021-07-29
MY185516A (en) 2021-05-19
US20250195494A1 (en) 2025-06-19
TWI694069B (zh) 2020-05-21
AU2021229240A1 (en) 2021-10-07
MX2017007065A (es) 2017-12-18
JP2018501217A (ja) 2018-01-18
BR112017011555A2 (pt) 2018-01-09
CA2968977A1 (en) 2016-06-09
PE20171646A1 (es) 2017-11-13
ES2910528T3 (es) 2022-05-12
US20170042877A1 (en) 2017-02-16
CL2021000044A1 (es) 2021-06-04
CN107567444A (zh) 2018-01-09
AU2020204286B2 (en) 2021-06-17
JP7069253B2 (ja) 2022-05-17
UA122780C2 (uk) 2021-01-06
TW201632511A (zh) 2016-09-16
AU2023258386A1 (en) 2023-11-23
AU2021229240B2 (en) 2023-08-24
HUE058212T2 (hu) 2022-07-28
US20180153871A1 (en) 2018-06-07
US10258614B2 (en) 2019-04-16
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SG11201704332YA (en) 2017-06-29
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ZA201703481B (en) 2023-12-20
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US10799493B2 (en) 2020-10-13
US9458130B2 (en) 2016-10-04
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US9730920B2 (en) 2017-08-15
DK3227273T3 (da) 2022-05-02
EP3227273A1 (en) 2017-10-11
PL3227273T3 (pl) 2022-05-30
IL280052A (en) 2021-03-01
JP2020172531A (ja) 2020-10-22
EA201791226A1 (ru) 2017-09-29
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