KR102618718B1 - 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도 - Google Patents

항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도 Download PDF

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KR102618718B1
KR102618718B1 KR1020227040417A KR20227040417A KR102618718B1 KR 102618718 B1 KR102618718 B1 KR 102618718B1 KR 1020227040417 A KR1020227040417 A KR 1020227040417A KR 20227040417 A KR20227040417 A KR 20227040417A KR 102618718 B1 KR102618718 B1 KR 102618718B1
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권병세
이한나
박진성
한승희
손현태
임선우
박혁준
유은혜
박성민
오연지
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주식회사 유틸렉스
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KR1020227040417A 2021-01-11 2022-01-11 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도 Active KR102618718B1 (ko)

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KR1020237005801A KR102576861B1 (ko) 2021-01-11 2022-01-11 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도

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US202163135812P 2021-01-11 2021-01-11
US63/135,812 2021-01-11
PCT/IB2022/000009 WO2022149050A2 (en) 2021-01-11 2022-01-11 Bispecific epitope binding protein comprising anti-4-1bb antibody and pd-1 protein or fragments thereof and use thereof

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KR1020237005801A Active KR102576861B1 (ko) 2021-01-11 2022-01-11 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도

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US (1) US12331116B2 (https=)
EP (1) EP4274852A4 (https=)
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Publication number Priority date Publication date Assignee Title
CN116615442A (zh) * 2020-09-08 2023-08-18 优特力克斯有限公司 程序性细胞死亡1多肽变体
USD1094401S1 (en) * 2023-02-20 2025-09-23 Sony Interactive Entertainment Inc. Display screen or portion thereof with transitional graphical user interface

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102178323B1 (ko) * 2013-11-29 2020-11-13 삼성전자주식회사 항 c-Met/항 Ang2 이중 특이 항체
US10899840B2 (en) * 2014-02-04 2021-01-26 Pfizer Inc. Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer
KR102259232B1 (ko) * 2014-08-25 2021-05-31 삼성전자주식회사 항 c-Met/항 Ang2 이중 특이 항체
HUE068868T2 (hu) * 2015-07-30 2025-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
JP2018537076A (ja) * 2015-10-23 2018-12-20 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． プログラム可能な普遍的細胞受容体およびその使用法
WO2017123548A1 (en) * 2016-01-14 2017-07-20 Seattle Children's Hospital (dba Seattle Children's Research Institute) Tumor-specific ifna secretion by car t-cells to reprogram the solid tumor microenvironment
EP3433269B1 (en) * 2016-03-23 2023-09-27 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
WO2018127473A1 (en) * 2017-01-03 2018-07-12 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9
CN112210010B (zh) * 2017-01-06 2023-12-05 优特力克斯有限公司 抗-人4-1bb抗体及其应用
JP2020522495A (ja) * 2017-05-30 2020-07-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｌａｇ−３抗体、ｐｄ−１経路阻害剤および免疫療法剤の組み合わせを含む組成物
WO2019089753A2 (en) * 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
US20210054089A1 (en) * 2018-03-23 2021-02-25 Eli Lilly And Company Anti-cd137 antibodies for combination with anti-pd-1 antibodies
WO2019241758A1 (en) * 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
JP7090204B2 (ja) * 2018-07-19 2022-06-23 イーライ リリー アンド カンパニー 免疫チェックポイントを標的とする二重特異性抗体
JP2022512541A (ja) * 2018-08-29 2022-02-07 シャタック ラボ，インコーポレイテッド Ｐｄ－１系キメラタンパク質を含む併用療法
JP2021535761A (ja) * 2018-09-14 2021-12-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ｓＰＤ−１バリアント−Ｆｃ融合タンパク質
WO2020068500A1 (en) * 2018-09-26 2020-04-02 Albert Einstein College Of Medicine Mutant variants of pd-1 receptor with selective binding to pd-l1 and uses thereof
GB201817822D0 (en) * 2018-10-31 2018-12-19 Autolus Ltd Binding domain
CN113286825B (zh) * 2018-11-30 2024-06-18 爱必乐生物公司 抗pd-l1/抗4-1bb双特异性抗体及其用途
WO2020229844A1 (en) * 2019-05-15 2020-11-19 Crescendo Biologics Limited Binding molecules
US20210107969A1 (en) * 2019-07-09 2021-04-15 The Johns Hopkins University Molecules, compositions and methods for treatment of cancer
CN110669137B (zh) * 2019-10-24 2021-07-16 高新 一种多特异性抗体及其制备方法和用途
CN116615442A (zh) * 2020-09-08 2023-08-18 优特力克斯有限公司 程序性细胞死亡1多肽变体

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WO2022149050A2 (en) 2022-07-14
US20220275083A1 (en) 2022-09-01
EP4274852A4 (en) 2025-02-26
KR102576861B1 (ko) 2023-09-11
EP4274852A2 (en) 2023-11-15
KR20230031376A (ko) 2023-03-07
JP2024502371A (ja) 2024-01-18
KR20220162808A (ko) 2022-12-08
CN117321079A (zh) 2023-12-29
US12331116B2 (en) 2025-06-17

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