KR102606167B1 - 불소 함유 치환 벤조티오펜 화합물, 그의 약학적 조성물 및 응용 - Google Patents
불소 함유 치환 벤조티오펜 화합물, 그의 약학적 조성물 및 응용 Download PDFInfo
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- KR102606167B1 KR102606167B1 KR1020217024365A KR20217024365A KR102606167B1 KR 102606167 B1 KR102606167 B1 KR 102606167B1 KR 1020217024365 A KR1020217024365 A KR 1020217024365A KR 20217024365 A KR20217024365 A KR 20217024365A KR 102606167 B1 KR102606167 B1 KR 102606167B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910002749.2 | 2019-01-02 | ||
| CN201910002749.2A CN111393405B (zh) | 2019-01-02 | 2019-01-02 | 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用 |
| PCT/CN2019/130605 WO2020140894A1 (zh) | 2019-01-02 | 2019-12-31 | 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210123314A KR20210123314A (ko) | 2021-10-13 |
| KR102606167B1 true KR102606167B1 (ko) | 2023-11-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020217024365A KR102606167B1 (ko) | 2019-01-02 | 2019-12-31 | 불소 함유 치환 벤조티오펜 화합물, 그의 약학적 조성물 및 응용 |
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| US (1) | US20220089561A1 (pt) |
| EP (1) | EP3907221A4 (pt) |
| JP (1) | JP7329052B2 (pt) |
| KR (1) | KR102606167B1 (pt) |
| CN (1) | CN111393405B (pt) |
| AU (1) | AU2019419663B2 (pt) |
| BR (1) | BR112021013099A2 (pt) |
| CA (1) | CA3125505C (pt) |
| TW (1) | TWI794576B (pt) |
| WO (1) | WO2020140894A1 (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067423A1 (en) | 2016-10-04 | 2018-04-12 | Merck Sharp & Dohme Corp. | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
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| GB0403148D0 (en) | 2004-02-12 | 2004-03-17 | Smithkline Beecham Corp | Chemical compounds |
| AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| JP2008536926A (ja) | 2005-04-20 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | ベンゾチオフェン誘導体 |
| MX2010011252A (es) * | 2008-04-15 | 2010-11-30 | Nippon Chemiphar Co | Activador para el receptor activado por el proliferador de peroxisoma. |
| WO2014198594A1 (en) * | 2013-06-10 | 2014-12-18 | Bayer Pharma Aktiengesellschaft | Novel compounds for the treatment of cancer |
| MX2016003486A (es) * | 2013-09-20 | 2016-06-28 | Biomarin Pharm Inc | Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. |
| US10793557B2 (en) | 2018-04-03 | 2020-10-06 | Merck Sharp & Dohme Corp. | Sting agonist compounds |
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2019
- 2019-01-02 CN CN201910002749.2A patent/CN111393405B/zh active Active
- 2019-12-31 EP EP19907455.0A patent/EP3907221A4/en active Pending
- 2019-12-31 TW TW108148626A patent/TWI794576B/zh active
- 2019-12-31 JP JP2021539037A patent/JP7329052B2/ja active Active
- 2019-12-31 CA CA3125505A patent/CA3125505C/en active Active
- 2019-12-31 BR BR112021013099-3A patent/BR112021013099A2/pt unknown
- 2019-12-31 WO PCT/CN2019/130605 patent/WO2020140894A1/zh unknown
- 2019-12-31 US US17/420,389 patent/US20220089561A1/en active Pending
- 2019-12-31 KR KR1020217024365A patent/KR102606167B1/ko active IP Right Grant
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067423A1 (en) | 2016-10-04 | 2018-04-12 | Merck Sharp & Dohme Corp. | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
Non-Patent Citations (1)
| Title |
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| STN Registry, RN 2228391-58-8 (2018.06.28. 등재)* |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3125505C (en) | 2022-03-01 |
| CA3125505A1 (en) | 2020-07-09 |
| JP7329052B2 (ja) | 2023-08-17 |
| AU2019419663B2 (en) | 2022-12-01 |
| TW202039457A (zh) | 2020-11-01 |
| US20220089561A1 (en) | 2022-03-24 |
| JP2022516922A (ja) | 2022-03-03 |
| BR112021013099A2 (pt) | 2021-09-21 |
| EP3907221A4 (en) | 2022-07-20 |
| WO2020140894A1 (zh) | 2020-07-09 |
| KR20210123314A (ko) | 2021-10-13 |
| CN111393405B (zh) | 2022-11-25 |
| CN111393405A (zh) | 2020-07-10 |
| TWI794576B (zh) | 2023-03-01 |
| AU2019419663A1 (en) | 2021-08-12 |
| EP3907221A1 (en) | 2021-11-10 |
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