KR102594005B1 - Cosmetic composition comprising cannabis liposome - Google Patents

Abstract

The present invention relates to a cosmetic composition using all of the roots, stems, and seeds of cannabis, and to technology for optimally utilizing the active ingredients of each part of the roots, stems, and seeds. In particular, the present invention is characterized in that a hemp complex containing hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil is liposomed and contained in a cosmetic composition.

Description

Cosmetic composition containing hemp liposomes {COSMETIC COMPOSITION COMPRISING CANNABIS LIPOSOME}

The present invention relates to a cosmetic composition using all of the roots, stems, and seeds of cannabis, and to technology for optimally utilizing the active ingredients of each part of the roots, stems, and seeds. In particular, the present invention is characterized in that a hemp complex containing hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil is liposomed and contained in a cosmetic composition.

Hemp ( Cannabis sativa L. ) is an annual herb belonging to the Hemp family. Its origin is Central Asia, and it is cultivated in various varieties around the world, including in Canada, the United States, and Europe, adapting well to various climates and regional conditions. Hemp varieties generally contain several cannabinoids and are a source of various secondary metabolites such as terpenes, flavonoids, and phytosterols (Non-patent Document 1).

When compared to various vegetable oils such as grape seed oil, soybean oil, and sunflower seed oil, the vegetable oil obtained from hemp seeds was found to have the highest content of phenolic compounds and a much higher antioxidant capacity. Depending on the part of the hemp, various flavonoids and Contains flavones, lignans, etc. Among them, Cannflavin A and Cannflavin B, a type of flavonoid found only in hemp, were found to have excellent antioxidant properties. More than 100 terpene-based compounds, which play a role in producing the aroma and taste of cannabis, have also been identified in cannabis, and exist in the form of various monoterpenoids and sesquiterpenoids. Terpenes have been found to be related to various pharmacological effects such as anti-cancer and anti-inflammatory effects, but research on terpene compounds extracted from hemp is still insufficient compared to THC (tetrahydrocannabinol).

However , most of the main components of cannabis, such as cannabinoids, terpenes, and flavonoids, are lipophilic substances and do not dissolve well in water, so various methods are being explored to increase bioavailability.

Poorly soluble active ingredients refer to active ingredients that do not dissolve well in water or other solvents, and their practicality is often limited due to their poor solubility. For example, more than 41% of drugs being developed as new drugs are abandoned due to poor solubility, and more than ⅓ of the drugs listed in the US Pharmacopeia are classified as poorly soluble drugs.

In order to use these poorly soluble active ingredients, additional substances must be added to resolve the poor solubility, but many cases have been reported in which use is restricted due to the toxicity of the added substances.

Hemp stems have a high cellulose content and are used to produce fibers in the textile and paper industries. Hemp waste is used as biofuel and cement raw material. Hemp seeds contain essential amino acids, proteins, and polyunsaturated fatty acids and are used as food and nutritional supplements. Hemp seed oil contains lignanamides and polyphenol compounds that have biological activity. Hemp root has been prescribed in traditional medicine to treat inflammation, joint pain, gout and other pathological conditions. There has been relatively little research on the pharmacology of the roots of cannabis species compared to the flowers or leaves, but research on the pharmacological activity of the roots has recently been increasing.

Lima et al. evaluated the toxicity, anti-inflammatory and antispasmodic effects of single and repeated administrations of water extract of cannabis root in mice in vitro, ex vivo and in vivo (Non-Patent Document 2). The results showed that spasms in airway smooth muscles were observed. showed an anti-inflammatory effect of cannabis root extract with no effect and no significant toxicity in mice. Additionally, Menezes et al., in an animal study using male mice, suggested that a water extract of cannabis root has the potential to treat cough and promote phlegm production (Non-patent Document 3).

The present invention relates to a cosmetic composition using all of the roots, stems, and seeds of cannabis, and is based on the idea of optimally utilizing the active ingredients of each part of the roots, stems, and seeds. In particular, the present invention is characterized in that a hemp complex containing hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil is liposomed and included in a cosmetic composition.

Looking at prior patent documents, (Patent Document 1) describes a cosmetic composition for skin whitening and wrinkle improvement containing hemp extract. The hemp extract here is described as being extracted as oil after peeling the hemp seeds. (Patent Document 2) describes a composition for anti-aging, anti-inflammatory or skin regeneration containing hemp stem extract as an active ingredient. (Patent Document 3) describes a cosmetic composition for improving atopic dermatitis containing cannabidiol or a derivative thereof.

Republic of Korea Patent Publication 10-2022-0049714 (published on April 22, 2022) Republic of Korea Patent Publication 10-2022-0091957 (published on July 1, 2022) Republic of Korea Patent Publication 10-2019-0098648 (published on August 22, 2019)

“Identification of para-coumaric acid and ethyl para-coumarate as major phenolic components of Cannabis (Cannabis sativa L.) roots” (Oh Chang-min, Kyungpook National University Graduate School, 2022) Lima, K.S.B., et al., Cannabis roots: Pharmacological and toxicological studies in mice. Journal of Ethnopharmacology, 2021. 271: p. 113868 Menezes, P.M.N., et al., Chemical Analysis by LC-MS of Cannabis sativa Root Samples from Northeast Brazil and Evaluation of Antitussive and Expectorant Activities. Planta Medica, 2021.)

Problem 1 is to provide a cosmetic composition that utilizes all of the roots, stems, and seeds of hemp. Problem 2 is to provide a cosmetic composition that optimally contains the active ingredients of each part of the root, stem, and seed of cannabis. Problem 3 is to provide a cosmetic composition using a process of liposomeizing hemp active ingredients in order to solve the problem of poor solubility of hemp ingredients in the cosmetic composition manufacturing process and optimally penetrate the hemp ingredients into the inner layer of the skin.

Solution 1 is a cosmetic composition containing liposomes obtained by liposomeizing a hemp complex containing hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil.

Solution 2: In solution 1, the hemp complex is,

A cosmetic composition comprising 0.001 to 20 parts by weight of hemp root extract, 0.001 to 20 parts by weight of hemp stem extract, 0.001 to 20 parts by weight of hemp root fermentation extract, and 0.001 to 20 parts by weight of hemp seed oil.

Solution 3 is that in solution 1 or 2, the liposome is,

Hydrolyzed collagen extract, glycerin, niacinamide, allantoin, adenosine, butylene glycol, hydrogenated lecithin, methyl trimethicone, sunflower seed oil, glycerol-25PCA isostearate, trimethylpentanediol /Adipic acid copolymer and tocopherol are additionally included and are liposomal.

Solution 4 is that in solution 1 or 2, the liposome is,

Hydrolyzed collagen extract, glycerin, niacinamide, allantoin, adenosine, hydrogenated lecithin, methyl trimethicone, sunflower seed oil, glycerol-25PCA isostearate, trimethylpentanediol/adipic acid co. Polymer, tocopherol, polyglyceryl-3methylglucose distearate, polyglyceryl-2stearate, glyceryl stearate, stearyl alcohol, jojoba seed oil, cetearyl glucoside, sorbitan olivate and cetearyl alcohol. It is a cosmetic composition, which is further characterized in that it contains liposomes.

Solution 5 is in solution 1 or 2,

It is a cosmetic composition characterized by additionally containing a preservative and fragrance.

The effectiveness of the invention is that 1. the active ingredients of cannabis roots, stems, and seeds can be optimally utilized; 2. the poorly soluble components of cannabis can be liposomed and delivered to the inside of the skin to exert an active effect on the skin. .

Terms or words used in this specification and claims should not be construed as limited to their ordinary or dictionary meanings, and the inventor should use the terms and concepts of the invention in the best possible way to explain them in accordance with the technical idea of the invention. It must be interpreted as written based on meaning and concept.

Therefore, the present invention is not limited to the presented manufacturing examples, experimental examples, and examples, and the technical idea of the present invention and the patent claims described below can be understood by those skilled in the art to which the present invention pertains. Various modifications and changes are possible within the scope of technical philosophy.

The present invention has been described focusing on preferred manufacturing examples, experimental examples, and examples with reference to the attached drawings, but it is clear to those skilled in the art that various modifications can be made without departing from the technical scope of these descriptions. Accordingly, the scope of the present invention may include many such variations.

Example 1. Cosmetic composition containing hemp complex liposomes

A cosmetic composition containing hemp complex liposomes is provided. The hemp complex includes hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil, and the hemp complex thus prepared is liposomed and included in a cosmetic composition.

The manufacturing method of the composition is looked at step by step as follows.

Step 1) Extract the hemp roots and stems respectively to prepare hemp root extract and hemp stem extract. Preferably, extraction is performed using an alcohol solvent, and depending on conditions, a carbon dioxide pressurized extraction technique or a supercritical technique may be additionally used.

Step 2) Fermentation of hemp roots using Bacillus strains produces a hemp root fermentation extract with converted ingredients. Preferably, Lactobacillus strains are used and conventional fermentation techniques are used.

Step 3) Prepare hemp seed oil. Preferably, hemp seeds are pressed to extract the oil.

Step 4) Liposome the hemp root extract, hemp stem extract, hemp root fermentation extract, and hemp seed oil.

Liposomes can be artificially created by applying ultrasound to a solution mixed with phospholipids or passing them through a filter with mechanical force. Liposomes can be made in various ways depending on the phospholipid and manufacturing method, and are structurally flexible. Liposomes are made up of phospholipids that form biological membranes, so they have excellent biocompatibility, degradability, and stability. Additionally, since it is made of phospholipids like cell membranes, it is also used as a model to study cell membranes of actual cells. Substances that can be delivered in liposomes include anticancer agents, contrast agents, antifungal agents, antibacterial agents, immunomodulators, antigens and antibodies, hemoglobin, proteins, fats, and DNA, and are widely used in actual clinical practice. The size of liposomes ranges from approximately tens of nanometers to several microns. There are many studies related to liposomes that began in 1965, but most of them explain the characteristics of liposome populations.

Recently, thanks to the development of nanotechnology, research on the properties or control of individual liposomes has been actively conducted. Liposomes are a drug delivery medium that is easy to mass produce and quality control, can be administered through various routes, can be administered repeatedly since there is no immune response, and is easy to change in structure and composition, so there is endless room for development. In addition, it is used in drug delivery and nanoparticle production to study the phenomenon of self-assembly (where molecules spontaneously form an ordered structure without artificial manipulation), which is attracting attention as a microprocessing tool in nanotechnology. Liposome structure formation is treated as an important model.

This step is to liposome the poorly soluble hemp ingredients and allow them to penetrate into the inner skin so that the hemp ingredients that have passed through the outer skin layer and the stratum corneum have the correct effect on the inner skin.

Depending on the formulation of the cosmetic composition, various ingredients are liposomed together. Preferably, 0.001 to 20 parts by weight of hemp stem extract, 0.001 to 20 parts by weight of hemp root extract, 0.001 to 20 parts by weight of Bacillus/Lactobacillus/hemp root fermentation extract, and 0.001 to 20 parts by weight of hemp seed oil are included to liposome. Preferably, liposomeization is performed using stirring and/or ultrasound at 40 to 55°C. Liposomeization can be achieved by selectively combining temperature, stirring, and ultrasound in each step.

Step 5) Complete the cosmetic composition by adding ingredients such as preservatives and fragrance.

Example 2. Liquid cannabis complex liposome cosmetic composition

Among the cosmetic compositions in which the hemp complex according to Example 1 was applied with liposomes, liquid toners, ampoules, etc. may be composed to have the compositions shown in [Table 1] below.

No. Ingredient dictionary name (Korean) Content (parts by weight) Manufacture process function One Hydrolyzed Collagen Extract 0.001~20









liposome process skin protectant 2 Hemp root extract 0.001~20 Hemp complex 3 Hemp stem extract 0.001~20 Hemp complex 4 glycerin 0.1~10 moisturizer 5 Niacinamide 2~5 skin conditioning agent 6 Bacillus/Lactobacillus/Hemp Root Fermentation Extract 0.001~20 Hemp complex 7 allantoin 0.01~0.5 skin conditioning agent 8 Adenosine 0.04 skin conditioning agent 9 Butylene glycol 0.1~10 moisturizer 10 Hydrogenated Lecithin 0.5~2 Surfactants 11 Methyltrimethicone 0.1~10 skin conditioning agent 12 sunflower seed oil 0.1~10 skin conditioning agent 13 Hemp seed oil 0.001~20 Hemp complex 14 Glycereth-25PCA Isostearate 0.1~3 skin conditioning agent 15 Trimethylpentanediol/adipic acid copolymer 0.1~3 skin conditioning agent 16 tocopherol 0.001~1 antioxidant 17 Dipropylene glycol 0.1~10 Addition process solvent 18 Hydroxyacetophenone 0.1~2 Addition process antiseptic 19 caprylyl glycol 0.1~2 Addition process antiseptic 20 1,2-hexanediol 0.1~2 Addition process antiseptic 21 Damask rose flower oil 0.001~2 Addition process incense

Example 3. Emulsion-like hemp complex liposome cosmetic composition

Among the cosmetic compositions in which the hemp complex according to Example 1 was applied with liposomes, emulsions, serums, creams, etc. may be composed to have the compositions shown in Table 2 below.

No. Ingredient dictionary name (Korean) Content (parts by weight) Manufacture process function One Hydrolyzed Collagen Extract 0.001~20













liposome process skin protectant 2 Hemp root extract 0.001~20 Hemp complex 3 Hemp stem extract 0.001~20 Hemp complex 4 glycerin 0.1~10 moisturizer 5 Niacinamide 2~5 skin conditioning agent 6 Bacillus/Lactobacillus/Hemp Root Fermentation Extract 0.001~20 Hemp complex 7 allantoin 0.01~0.5 skin conditioning agent 8 Adenosine 0.04 skin conditioning agent 9 Hydrogenated Lecithin 0.5~2 Surfactants 10 Methyltrimethicone 0.1~10 skin conditioning agent 11 sunflower seed oil 0.1~10 skin conditioning agent 12 Hemp seed oil 0.001~20 Hemp complex 13 Glycereth-25PCA Isostearate 0.1~3 skin conditioning agent 14 Trimethylpentanediol/adipic acid copolymer 0.1~3 skin conditioning agent 15 tocopherol 0.001~1 antioxidant 16 Polyglyceryl-3methylglucose distearate 0.1~3 skin conditioning agent 17 Polyglyceryl-2stearate 0.1~3 skin conditioning agent 18 Glyceryl Stearate 0.1~3 emulsifier 19 stearyl alcohol 0.1~3 Emulsion stabilizer 20 Jojoba seed oil 0.1~10 skin conditioning agent 21 Cetearyl Glucoside 0.1~3 Surfactants 22 Sorbitan Olivate 0.1~3 Surfactants 23 Cetearyl alcohol 0.1~3 Emulsion stabilizer 24 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.1~0.5 Addition process thickener 25 Dipropylene glycol 0.1~10 Addition process solvent 26 Hydroxyacetophenone 0.1~2 Addition process antiseptic 27 caprylyl glycol 0.1~2 Addition process antiseptic 28 1,2-hexanediol 0.1~2 Addition process antiseptic 29 Damask rose flower oil 0.001~2 Addition process incense

Example 4. Other hemp complex liposome cosmetic compositions

The cosmetic composition of the present invention can be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing products. , oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, etc., but is not limited thereto. More specifically, it can be manufactured in the form of softening lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, or powder.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier ingredient. You can.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and microcrystals. Cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier component. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a surfactant-containing cleansing agent, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid amide ether. Sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it can be applied to the skin and then wiped off, removed, or washed with water. As a specific example, the soap is liquid soap, powdered soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation is cleansing cream. , cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.

So far, the present invention has been examined with a focus on preferred embodiments.

The embodiments described in this specification and the configurations shown in the drawings are related to one of the most preferred embodiments of the present invention, and do not represent the entire technical idea of the present invention, so various equivalents and modifications that can replace them are provided. It should be understood that there may be examples.

Therefore, the present invention is not limited to the presented embodiments, and is within the equivalent scope of the technical idea of the present invention and the technical idea described in the patent claims below, as can be understood by those skilled in the art to which the present invention pertains. There may be embodiments in which various modifications and changes are possible.

Claims (5)

A hemp complex consisting of 0.001 to 20 parts by weight of hemp root extract, 0.001 to 20 parts by weight of hemp stem extract, 0.001 to 20 parts by weight of hemp root fermentation extract, and 0.001 to 20 parts by weight of hemp seed oil,
Skin protectant hydrolyzed collagen extract 0.001~20 parts by weight, moisturizer glycerin 0.1~10 parts by weight, skin conditioning agent niacinamide 2~5 parts by weight, skin conditioning agent allantoin 0.01~0.5 parts by weight, skin conditioning agent adenosine 0.04 parts by weight , humectant butylene glycol 0.1 to 10 parts by weight, surfactant hydrogenated lecithin 0.5 to 2 parts by weight, skin conditioning agent methyl trimethicone 0.1 to 10 parts by weight, skin conditioning agent sunflower seed oil 0.1 to 10 parts by weight, skin Mix 0.1 to 3 parts by weight of conditioning agent Glycereth-25PCA isostearate, 0.1 to 3 parts by weight of skin conditioning agent trimethylpentanediol/adipic acid copolymer, and 0.001 to 1 part by weight of antioxidant tocopherol, then form into liposomes. manufacturing,
A cosmetic composition containing a liposome of a hemp complex, characterized in that it is a composition prepared by adding 0.1 to 10 parts by weight of solvent dipropylene glycol, a preservative, and 0.001 to 2 parts by weight of fragrant damask rose flower oil to the liposome. delete delete A hemp complex consisting of 0.001 to 20 parts by weight of hemp root extract, 0.001 to 20 parts by weight of hemp stem extract, 0.001 to 20 parts by weight of hemp root fermentation extract, and 0.001 to 20 parts by weight of hemp seed oil,
Skin protectant hydrolyzed collagen extract 0.001~20 parts by weight, moisturizer glycerin 0.1~10 parts by weight, skin conditioning agent niacinamide 2~5 parts by weight, skin conditioning agent allantoin 0.01~0.5 parts by weight, skin conditioning agent adenosine 0.04 parts by weight , surfactant hydrogenated lecithin 0.5~2 parts by weight, skin conditioning agent methyl trimethicone 0.1~10 parts by weight, skin conditioning agent sunflower seed oil 0.1~10 parts by weight, skin conditioning agent Glycereth-25PCA isostearate 0.1~3 parts by weight, skin conditioning agent trimethylpentanediol/adipic acid copolymer 0.1~3 parts by weight, antioxidant tocopherol 0.001~1 part by weight, skin conditioning agent polyglyceryl-3methylglucose distearate 0.1~ 3 parts by weight, skin conditioning agent polyglyceryl-2 stearate 0.1~3 parts by weight, emulsifier glyceryl stearate 0.1~3 parts by weight, emulsion stabilizer stearyl alcohol 0.1~3 parts by weight, skin conditioning agent jojoba seed oil 0.1~ Prepare liposomes by mixing 10 parts by weight, 0.1 to 3 parts by weight of surfactant cetearyl glucoside, 0.1 to 3 parts by weight of surfactant sorbitan olivate, and 0.1 to 3 parts by weight of emulsion stabilizer cetearyl alcohol,
Prepared by adding 0.1 to 0.5 parts by weight of thickener acrylate/C10-30 alkyl acrylate crosspolymer, 0.1 to 10 parts by weight of solvent dipropylene glycol, preservative, and 0.001 to 2 parts by weight of fragrance damask rose flower oil to the liposome. A cosmetic composition containing liposomes of a hemp complex, characterized in that it is a composition made of hemp. delete