KR102589338B1 - Manufacturing method of pharmaceutical composition comprising the extract of gastrodia and pine pollen - Google Patents

Abstract

The present invention relates to a method for manufacturing a pharmaceutical composition containing extracts of Cheonma and pine pollen, and more specifically, to a method for manufacturing a health pill that is effective in improving blood circulation, mental and physical stability, strengthening cerebrovascular vessels, improving liver function, and improving memory. will be.
According to various embodiments, a method for producing a pharmaceutical composition containing extracts of Cheonma and pine pollen includes 35 to 45 parts by weight of Cheonma, 15 to 25 parts by weight of pine pollen, 15 to 25 parts by weight of (white) Bokryeong, and 5 to 10 parts by weight of plantain. A first step of preparing medicinal ingredients consisting of 5 to 10 parts by weight of thyme; A second step of preparing and powdering the herbal medicine; A third step of mixing the powder; A fourth step of preparing dough by mixing the mixed powder with natural flower honey; and a fifth step of forming the dough into a ring shape.

Description

{MANUFACTURING METHOD OF PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF GASTRODIA AND PINE POLLEN}

The present invention relates to a method for manufacturing a pharmaceutical composition containing extracts of Cheonma and pine pollen, and more specifically, to a method for manufacturing a health pill that is effective in improving blood circulation, mental and physical stability, strengthening cerebrovascular vessels, improving liver function, and improving memory. will be.

Adult diseases such as chronic fatigue, decreased blood circulation, and decreased liver function are increasing due to stress, increased drinking, and lack of exercise, and the consumption of health functional foods such as herbal medicine is increasing.

In addition to treating diseases, herbal medicine is used for purposes such as health promotion, and is consumed in a traditional way by boiling it or storing it in a pouch and drinking it at a set time.

Meanwhile, Gastrodiaerhizoma, which is widely used as an ingredient in herbal medicine, is a perennial plant belonging to the Orchidaceae family that conveniently coexists with mulberry mushrooms. It has no leaves, and its underground tubers are used as medicine. Cheonma's exterior is light yellow-yellow brown with patterns, and has nicknames such as Jeokjeon, Guidogu, Imo, Shincho, and Jeongpungcho, and was first recorded under the name Cheonma in the Noegongpoguron of the Jin Dynasty. Cheonma is non-toxic and has a great taste. It is mainly used for headaches, quadriplegia, hemiplegia, dizziness, high blood pressure, diabetes, neurological diseases, liver disease, speech disorders, childhood convulsions, especially for relieving stress in modern people, reducing obesity, and relieving drinking. It is effective, and its cholesterol-lowering effect has recently been reported.

Most of the ingredients contained in Cheonma are phenolic compounds, and gastrodin, phenolic glycosides, sulfur-containing phenolic compounds, organic acids, sugars, and beta-sitosterol have been reported separately. In addition, sterols, cholesterol, p-hydroxylbenzyl alcohol, vanillin, vanillil alcohol, p-hydroxybenzaldehyde, etc. The ingredients are also known. Research on the pharmacological effects of each ingredient is also being actively conducted, with the main focus being research on Gastrodin and p-Hydroxybenzyl alcohol.

Gastrodin is effective in heart disease by increasing memory and cognition, suppressing neuropathy such as depression and convulsions, lowering blood pressure, and suppressing ischemic disease. It is also known to activate liver cells, lower blood sugar, and have anti-inflammatory effects.

Republic of Korea Patent No. 10-2240938A - Hwanseong health food and its manufacturing method (2021.04.09)

Unlike other common herbal medicines, Cheonma has a very strong unpleasant odor, so its sensory characteristics become a problem when applied to food, and the technology for developing pills using Cheonma is quite limited.

The present invention was devised to solve the above problems. In the present invention, in order to manufacture a product with improved active ingredients and functionality without using food additives such as chemical additives and excipients, such as washing of medicinal materials, preparation, mixing ratio, etc. By optimizing the manufacturing conditions, we aim to provide a manufacturing method for health pills that are highly palatable while helping with blood vessel management and blood circulation.

According to various embodiments, a method for producing a pharmaceutical composition containing extracts of Cheonma and pine pollen includes 35 to 45 parts by weight of Cheonma and 15 to 25 parts by weight of pine pollen, 15 to 25 parts by weight of (white) Bokryeong, and 5 to 10 parts by weight of plantain. A first step of preparing medicinal ingredients consisting of 5 to 10 parts by weight of thyme; A second step of preparing and powdering the herbal medicine; A third step of mixing the powder; A fourth step of preparing dough by mixing the mixed powder with natural flower honey; and a fifth step of forming the dough into a ring shape.

The method for producing a pharmaceutical composition containing extracts of Chrysanthemum and pine pollen according to the present invention improves the user's convenience of taking, and has effects such as improving blood circulation, mental and physical stability, strengthening cerebrovascular vessels, improving liver function, and improving memory.

Figure 1 is a manufacturing process diagram of a method for manufacturing a pharmaceutical composition containing extracts of Chunma and pine pollen according to a preferred embodiment of the present invention.

Hereinafter, the method for producing a pharmaceutical composition containing the extract of Chunma and pine pollen according to the present invention will be described in more detail through examples and comparative examples. However, the specific examples introduced below are provided as examples so that the idea of the present invention can be sufficiently conveyed to those skilled in the art.

Accordingly, the present invention is not limited to the embodiments presented below and may be embodied in other forms. The embodiments presented below are only described to clarify the spirit of the invention, and the invention is not limited thereto.

At this time, if there is no other definition in the technical and scientific terms used, they have meanings commonly understood by those skilled in the art to which this invention pertains, and the following description will not unnecessarily obscure the gist of the present invention. Descriptions of possible notification functions and configurations are omitted.

Additionally, as used in the specification and appended claims, the singular forms “a,” “an,” and “the” are intended to also include the plural forms, unless the context clearly dictates otherwise.

First, Cheonma, a major component for achieving the present invention, is the best new drug for brain diseases. It is not only incredibly effective in treating brain diseases such as headaches, stroke, insomnia, high blood pressure, and depression, but is also highly effective in treating a wide range of diseases, including stomach ulcers, epilepsy, cirrhosis, diabetes, food poisoning, disc disease, leukemia, and cancer. You can.

For example, in 『Hyangyakjipseongbang』, Cheonma is said to be "spicy in taste, mild in nature, and non-poisonous. It treats various types of paralysis caused by customs, shriveling of limbs, cold liver in children, and fretting easily. It also treats the waist and knees. "It helps you use your body well and increases your muscle strength. If you eat it for a long time, you will gain energy, feel better, and live longer. It grows in the mountains, and the roots are dug up in the fifth month of the lunar calendar and dried in the sun," he explains.

In addition, in 『Bonchogangmok』, "Cheonma is called Jeokjeonji or Jeongpungcho by other names. It has a sweet taste and a neutral nature. It is good for poor circulation, various types of paralysis, inability to use limbs, and blurred mind while talking a lot. “It treats things like being startled and having a blurred mind,” he explains.

According to various embodiments of the present invention, Cheonma acts on the muscle layer of blood vessels, especially blood vessels in the kidneys, and plays a role in dilating blood vessels, lowering blood pressure and increasing blood flow in the kidneys to promote excretion of salts. It increases the effect of prostaglandin, an immunomodulator, and can play a role in improving vascular inflammation by suppressing NF-kB, an inflammatory transcript. In order to increase this efficacy, the present invention may be characterized by soaking Cheonma in vinegar for 30 to 90 minutes, more preferably about 60 minutes, then drying and milling. Through this manufacturing method, the unique odor of Cheonma can be reduced by about 50%.

Cheonma has no scars and is preferably harvested in the fall, sorted, dried, and used in powder form. In order to show effects on blood circulation, mental and physical stability, strengthening cerebrovascular vessels, improving liver function, and improving memory, it is recommended to use 35 to 35 percent of Cheonma. It is desirable to have a range within 45 parts by weight.

Song pollen, which is the main component for achieving the present invention, is called pine flower or pine hwang. In Korea, it is light yellow pine pollen collected only for about 10 days from April to May. It contains a large amount of nutrients useful to the human body and has been used for making tea meals and pine wine since ancient times. It has been used in poetry. In addition, in the private sector, it has been used to treat diabetes and fatty liver and as a hemostatic agent. In oriental medicine, it has a tonic and tonic effect and is used to treat nervous disorders, heart disease, acute and chronic prostatitis, hyperlipidemia, arteriosclerosis, and anemia. In particular, pine pollen is used in Donguibogam. It is said that eating it strengthens the body and its efficacy is superior to that of pine bark, pine leaves, and fruit.

Pine pollen has a single flower source, is pure in quality, has stable ingredients, and is free from pesticide residues and animal hormones.

Pine pollen contains over 200 different nutrients. For example, pine pollen contains various proteins, over 20 amino acids, over 30 minerals and trace elements, 14 vitamins, and close to a hundred enzymes and coenzymes necessary for the human body, as well as nucleic acids, monosaccharides, polysaccharides, and vitamins. It contains various nutrients such as perunsaturated fatty acids. In particular, pine pollen, which has a breakage rate of over 99%, is more advantageous for the human body to absorb because it contains sufficient nutrients and active substances.

Pine pollen is a high-quality nutritional supplement with abundant nutrients. When taken over a long period of time, it has very beneficial effects in many ways, including endocrine regulation, strengthening immunity, protecting the heart and liver, strengthening digestive function, controlling weight, preventing colds, preventing anemia, and beautifying the skin. see.

According to various embodiments of the present invention, round flower clusters collected when flowers bloom in April to May can be used. Pine pollen can be collected by drying the collected round flower clusters in the sun, crushing them to shake off the pollen, sifting the pollen to remove foreign substances, and drying it in the sun or by heating it.

The pine pollen extract and its active fraction materials of the present invention can be manufactured into powder through a conventional powdering process such as reduced pressure drying, freeze drying, or spray drying. They are not decomposed by various decomposition enzymes in plasma, and remain active even when heat treated at 100 degrees Celsius and at pH 2 in the human stomach.

(Baek) Bokryeong, the main component for achieving the present invention, is called Four Seasons New Medicine. This means that it is the best medicine for any person and in any season. This is because (Baek) Bokryeong is not only a good medicine regardless of the person's constitution or season, but also has a good effect on all diseases caused by cold, heat, wind, and moisture. .

In the 『Dictionary of Oriental Medicine』, regarding the medicinal properties of (Baek) Bokryeong, “The taste is sweet and boring, and the nature is plain. It acts on menopause, nasal passages, cardiac nerves, and cystoscope. He explained, “It helps urinate well, protects against rain, reduces phlegm, and stabilizes the mind.” Pharmacological experiments have also shown that it has diuretic effects, lowering blood sugar levels, and sedative effects.

(Baek) Bokryeong's polysaccharide exhibits immune-boosting and anti-cancer effects. For example, (Baek) Bokryeong is used for swelling of the emptiness, ascites, phlegm, vomiting, diarrhea, difficulty urinating, heart palpitations, diarrhea, and insomnia. , forgetfulness, chronic digestive diseases, etc.

According to various embodiments of the present invention, (Baek) Bokryeong consumes energy if used without discarding the peel, so wash it cleanly, soak it in water, stir, and discard what floats. In order to improve the medicinal effect and ensure that the medicinal energy circulates well when taken, Takju (Takju) is used. Makgeolli) can be used to steam and dry the medicine until it becomes soft and then mill it. The legal system using Takju (makgeolli) allows medicinal energy to circulate throughout the body and spread medicinal energy upwards (upper body) to the head, face, hands, fingers, neck, and navel.

For example, (white) Bokryeong can be milled by soaking and maturing it in makgeolli for 80 to 100 minutes, steaming it at 90 to 120 degrees Celsius for 20 to 25 hours, and then drying it for 20 to 25 hours, repeating the process several times. there is.

(Baek) Bokryeong is preferably soaked in alcohol for 80 to 100 minutes, aged, steamed at 90 to 120 degrees Celsius for 20 to 25 hours, and then dried for 20 to 25 hours. This process is repeated nine times, preferably for less than 80 minutes. If it is soaked in alcohol, the ripening will not occur properly, and if it exceeds 100 minutes, the ripening may be excessive and the taste and efficacy may be reduced. If it is steamed below 90 degrees Celsius, the manufacturing time will be longer and the manufacturing cost will increase. If steamed above 120 degrees Celsius, it may become overcooked and brittle; if steamed for less than 20 hours, it may not be steamed properly and its effectiveness may be reduced; if steamed beyond 25 hours, it may become overcooked and the product may become brittle. As the time increases, the manufacturing cost increases. If the drying time is less than 20 hours, drying may not be done properly, and if the drying time exceeds 25 hours, excessive drying and brittleness problems may occur. It is desirable to have conditions. On the other hand, it may be desirable for Bokryeong to have a range within 15 to 25 parts by weight.

Psyllium (plantain), a key component for achieving the present invention, has the effect of reducing cholesterol levels. For example, the low-molecular-weight aromatic component contained in plantain helps with antioxidant activity, and the component called pectin and dietary fiber help prevent adult diseases such as arteriosclerosis and fatty liver by removing and suppressing free radicals present in the body.

Plantain also has an anti-bronchitis effect. According to Donguibogam, it is recorded that it helps relieve bronchitis, colds, and sore throats. For example, plantain contains platagine. This ingredient suppresses coughing more than usual, reduces phlegm, and moisturizes the bronchial mucosa by strengthening the secretory function of the mucous membrane. When the bronchial mucosa becomes moist, it is very good for sore throat and asthma.

Plantains contain a large amount of vitamin A and antioxidants, which are helpful for eye health.

According to various embodiments of the present invention, plantain contains a large amount of mucilage, so it can be roasted over low heat at 30 to 40 degrees Celsius, completely dried, taken out when the outer skin pops, cooled, and milled for use. At this time, the material may be completely dried until the moisture content is 5% or less. Meanwhile, it may be desirable to have plantain in the range of 5 to 10 parts by weight.

The saponin and calcium components contained in the root of the root of oxalum, which is the main component for achieving the present invention, strengthen joints and help relieve inflammation and relieve pain.

For example, coriander is rich in calcium, a major component of bones, and saponin, which helps relieve inflammation, making joint movements smoother and strengthening muscles and bones, which can help relieve arthritis.

In addition, Donguibogam's records state that Useul improves stamina and strengthens legs, and is a herb that has been used since ancient times.

Garlic is good for erectile dysfunction and helps with irregular menstruation in women. It is also known to relieve back pain symptoms due to the analgesic and anti-inflammatory effects of saponin, which has anti-inflammatory effects, and ecdysone, a component of hyssop root.

According to various embodiments of the present invention, snail can be steamed, dried, and then milled for the purpose of protecting the liver and kidneys and strengthening the muscles and skeleton. In particular, to relieve blood clots, remove boils, and menstruation, raw snails can be thoroughly washed, dried, and then milled. On the other hand, it may be preferable that the amount of oxal is within the range of 5 to 10 parts by weight.

Hereinafter, the method for producing a pharmaceutical composition containing extracts of Chunma and pine pollen according to a preferred embodiment of the present invention will be described in detail as follows.

Figure 1 is a manufacturing process diagram of a method for manufacturing a pharmaceutical composition containing extracts of Chunma and pine pollen according to a preferred embodiment of the present invention.

The method for manufacturing a pharmaceutical composition according to various embodiments of the present invention may include a first step (10) of preparing cheonma, pine pollen, (white) bokryeong, plantain, and sage. For example, it can be prepared to be 35 to 45 parts by weight of Cheonma, 15 to 25 parts by weight of pine pollen, 15 to 25 parts by weight of (white) Bokryeong, 5 to 10 parts by weight of plantain, and 5 to 10 parts by weight of sage.

The method for producing a pharmaceutical composition according to various embodiments of the present invention includes a second step of powdering the dried horseradish, pine pollen, (white) bokryeong, plantain, and syringa from which impurities have been removed prepared in the first step (10), respectively. (20) may be included. After going through the legal process, 35 to 45 parts by weight of dried hemp, 15 to 25 parts by weight of pine pollen, 15 to 25 parts by weight of (white) bokryeong, 5 to 10 parts by weight of plantain, and 5 to 10 parts by weight of lyssop are placed in a mill. and mill it into powder.

In the second step (20), it may include soaking the dried hemp in vinegar for 30 to 90 minutes, more preferably 60 minutes, then drying and milling.

The reason for using the method of soaking cheonma in vinegar for 30 to 90 minutes is that vinegar contains ingredients that improve hyperlipidemia and lower high blood pressure, blood sugar levels, and uric acid levels, and at the same time has the effect of protecting the food's inherent nutrients and increasing the absorption rate. Because it exists.

In addition, soaking the Cheonma in vinegar for about 60 minutes is the time necessary for the vinegar to be evenly absorbed into the Cheonma, and at the same time, it is the time to prevent the loss of the active ingredients of the Cheonma due to osmotic pressure.

In addition, in the second step (20), the (white) bokryeong is soaked in makgeolli for 80 to 100 minutes and aged, then steamed at 90 to 120 degrees Celsius for 20 to 25 hours, and then dried for 20 to 25 hours several times. It may be configured to include the step of repeated milling.

Additionally, the second step (0) may include roasting the plantain over a low heat of 30 to 40 degrees Celsius, taking it out when it is completely dried and the outer skin pops, cooling it, and milling it.

According to one embodiment, the second step 20 may include a pulverizing step to a size of 5 nm to 20 nm.

The method for producing a pharmaceutical composition according to various embodiments of the present invention includes putting the horseradish powder, pine flower powder, (white) bokryeong powder, plantain powder, and hyssop powder in a mixing bowl in the second step (S20) and stirring for 10 to 30 minutes. It may include a third step (30) of mixing to ensure that the powder is evenly mixed.

In addition, the third step 30 may further include a removal step of magnetically removing metal powder that may be generated by the mill.

To further explain, the removal step is to grind the solid material into fine powder using a mill made of metal materials such as stainless steel, silver-plated metal, etc., and fine metal powder that may be generated in the process of milling the solid medicine. By removing it with one's own power, it becomes possible to safely consume Hwanseong health foods manufactured later.

The method for producing a pharmaceutical composition according to various embodiments of the present invention may include the fourth step (40) of kneading the mixed Chunma powder, pine flower powder, (white) Bokryeong powder, plantain powder, and Hyssop powder with glutinous rice paste. there is.

The method of manufacturing a pharmaceutical composition according to various embodiments of the present invention involves forming the dough in the fourth step (40) into a ring shape, and in the fifth step (50) manufacturing it in a size that can be easily consumed by the user at once. may include.

In addition, the dough in the fifth step 50 is molded into a 4g to 6g ring shape so that the user can easily consume it and store it conveniently.

If the dough in the 5th step (50) is molded into less than 4g, it is difficult to obtain the effect from just one piece, so multiple pieces must be consumed, which causes inconvenience, and when molded into more than 6g, it is difficult to consume at once. Therefore, it is desirable to mold it to a size within the above range.

Thereafter, the molded Hwanseong health food can be individually packaged in paper-based packaging, placed in a dedicated container, and stored and distributed at a room temperature of 1 to 30 degrees Celsius.

As described above, although the embodiments have been described with limited examples and drawings, various modifications and variations can be made by those skilled in the art from the above description. For example, the described techniques are performed in a different order than the described method, and/or components of the described system, structure, device, circuit, etc. are combined or combined in a different form than the described method, or other components are used. Alternatively, appropriate results may be achieved even if substituted or substituted by an equivalent. Therefore, other implementations, other embodiments, and equivalents of the claims also fall within the scope of the claims described below.

Claims (5)

A first step of preparing medicinal materials consisting of 35 to 45 parts by weight of Cheonma, 15 to 25 parts by weight of pine pollen, 15 to 25 parts by weight of (white) Bokryeong, 5 to 10 parts by weight of plantain, and 5 to 10 parts by weight of Hyssop;
A second step of preparing and powdering the herbal medicine;
A third step of mixing the powder;
A fourth step of preparing dough by mixing the mixed powder with natural flower honey; and
It includes a fifth step of forming the dough into a ring shape,
The second step is,
Soaking the cloth in vinegar for 30 to 60 minutes and then drying and milling it;
Milling the (white) Bokryeong by soaking it in makgeolli for 80 to 100 minutes, aging it, steaming it at 90 to 120 degrees Celsius for 20 to 25 hours, and then drying it for 20 to 25 hours multiple times; and
Roasting the plantain over low heat at 30 to 40 degrees Celsius and completely drying it until the moisture content is less than 5% by weight,
The third step is,
A method for producing a pharmaceutical composition comprising a removal step of magnetically removing metal powder that may be generated by the mill.
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