KR102587339B1 - N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법 - Google Patents

N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법 Download PDF

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Publication number
KR102587339B1
KR102587339B1 KR1020160176608A KR20160176608A KR102587339B1 KR 102587339 B1 KR102587339 B1 KR 102587339B1 KR 1020160176608 A KR1020160176608 A KR 1020160176608A KR 20160176608 A KR20160176608 A KR 20160176608A KR 102587339 B1 KR102587339 B1 KR 102587339B1
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KR
South Korea
Prior art keywords
phenyl
methanesulfonamide
difluoro
ethyl
amino
Prior art date
Application number
KR1020160176608A
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English (en)
Korean (ko)
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KR20180073113A (ko
Inventor
우병영
이기화
박미영
박영호
Original Assignee
(주)아모레퍼시픽
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Priority to KR1020160176608A priority Critical patent/KR102587339B1/ko
Priority to PCT/KR2017/013885 priority patent/WO2018117467A1/fr
Priority to TW106144957A priority patent/TWI741111B/zh
Publication of KR20180073113A publication Critical patent/KR20180073113A/ko
Application granted granted Critical
Publication of KR102587339B1 publication Critical patent/KR102587339B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020160176608A 2016-12-22 2016-12-22 N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법 KR102587339B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020160176608A KR102587339B1 (ko) 2016-12-22 2016-12-22 N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법
PCT/KR2017/013885 WO2018117467A1 (fr) 2016-12-22 2017-11-30 Procédé de racémisation d'énantiomères de n-[4-(1-amino-éthyl)-2,6-difluoro-phényl]-méthanesulfonamide
TW106144957A TWI741111B (zh) 2016-12-22 2017-12-21 N-[4-(1-氨乙基)-2,6-二氟苯基]-甲磺醯胺之鏡像異構物的消旋方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160176608A KR102587339B1 (ko) 2016-12-22 2016-12-22 N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법

Publications (2)

Publication Number Publication Date
KR20180073113A KR20180073113A (ko) 2018-07-02
KR102587339B1 true KR102587339B1 (ko) 2023-10-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160176608A KR102587339B1 (ko) 2016-12-22 2016-12-22 N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법

Country Status (3)

Country Link
KR (1) KR102587339B1 (fr)
TW (1) TWI741111B (fr)
WO (1) WO2018117467A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109608368B (zh) * 2018-10-24 2021-03-09 常州市阳光药业有限公司 N-[4-(1-氨基乙基)-2,6-二氟苯基]甲磺酰胺的合成及拆分方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016133317A1 (fr) * 2015-02-17 2016-08-25 (주)아모레퍼시픽 Procédé de résolution chirale de dérivés n-[4-(1-aminoéthyl)-phényl]-sulfonamide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007129188A1 (fr) 2006-05-10 2007-11-15 Pfizer Japan Inc. Composé de cyclopropanecarboxamide
WO2007133637A2 (fr) 2006-05-10 2007-11-22 Renovis, Inc. Dérivés d'amides en tant que ligands de canal ionique et compositions pharmaceutiques et méthodes d'utilisation desdits dérivés
KR101410318B1 (ko) 2006-07-27 2014-06-27 (주)아모레퍼시픽 바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물
JP2011201778A (ja) 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ｐ−置換アリールアセトアミドを有するヘテロシクリデン誘導体
US20130345475A1 (en) * 2012-06-25 2013-12-26 Basf Se Process for the racemization of optically active arylalkylamines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016133317A1 (fr) * 2015-02-17 2016-08-25 (주)아모레퍼시픽 Procédé de résolution chirale de dérivés n-[4-(1-aminoéthyl)-phényl]-sulfonamide

Also Published As

Publication number Publication date
WO2018117467A1 (fr) 2018-06-28
TW201833071A (zh) 2018-09-16
KR20180073113A (ko) 2018-07-02
TWI741111B (zh) 2021-10-01

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