KR102571296B1 - P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 - Google Patents
P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 Download PDFInfo
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- KR102571296B1 KR102571296B1 KR1020197009639A KR20197009639A KR102571296B1 KR 102571296 B1 KR102571296 B1 KR 102571296B1 KR 1020197009639 A KR1020197009639 A KR 1020197009639A KR 20197009639 A KR20197009639 A KR 20197009639A KR 102571296 B1 KR102571296 B1 KR 102571296B1
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662384656P | 2016-09-07 | 2016-09-07 | |
| US62/384,656 | 2016-09-07 | ||
| PCT/US2017/050347 WO2018048953A1 (en) | 2016-09-07 | 2017-09-06 | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190057316A KR20190057316A (ko) | 2019-05-28 |
| KR102571296B1 true KR102571296B1 (ko) | 2023-08-28 |
Family
ID=61562356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197009639A Active KR102571296B1 (ko) | 2016-09-07 | 2017-09-06 | P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11077108B2 (enExample) |
| EP (1) | EP3510029B1 (enExample) |
| JP (1) | JP7187037B2 (enExample) |
| KR (1) | KR102571296B1 (enExample) |
| CN (1) | CN109906222B (enExample) |
| AU (1) | AU2017324942B2 (enExample) |
| CA (1) | CA3039026A1 (enExample) |
| WO (1) | WO2018048953A1 (enExample) |
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| JP2022528790A (ja) * | 2019-04-15 | 2022-06-15 | ヤンセン ファーマシューティカ エヌ.ベー. | スピーチ分析を使用して認知低下を検出するためのシステム及び方法 |
| CN116832160A (zh) * | 2023-03-15 | 2023-10-03 | 上海市宝山区吴淞中心医院 | Aβ1-42在制备子痫前期治疗药物或诊断试剂盒中的用途 |
| CN118121593B (zh) * | 2024-02-26 | 2025-02-14 | 首都医科大学宣武医院 | 一种用于预防和/或治疗阿尔茨海默病的药物组合物及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033750A1 (en) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Corticotropin releasing factor antagonists |
| US20050032846A1 (en) * | 1995-11-08 | 2005-02-10 | Pfizer Inc. | Corticotropin releasing factor antagonists |
| WO2013123426A1 (en) * | 2012-02-18 | 2013-08-22 | Buck Institute For Research On Aging | Formulations and methods for the treatment or prophylaxis of pre-mci and/or pre-alzheimer's conditions |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB590706A (en) * | 1945-02-27 | 1947-07-25 | Frederick Robert Basford | New pyrimidine compounds |
| US6020492A (en) | 1995-05-12 | 2000-02-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| US6403599B1 (en) * | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| AU738304B2 (en) | 1995-10-13 | 2001-09-13 | Neurogen Corporation | Certain pyrrolopyridine derivatives; novel CRF 1 specific ligands |
| US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
| AU5614198A (en) | 1996-12-18 | 1998-07-15 | Neurogen Corporation | Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors |
| US6756367B2 (en) * | 1998-02-03 | 2004-06-29 | Novartis Ag | Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them |
| GB9802251D0 (en) * | 1998-02-03 | 1998-04-01 | Ciba Geigy Ag | Organic compounds |
| US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
| JP2002517501A (ja) | 1998-06-09 | 2002-06-18 | ニューロゲン コーポレイション | ピリド[2,3−b]インドリジン誘導体およびそのアザ類似化合物;CRF1特異的リガンド |
| JP2002543200A (ja) | 1999-04-30 | 2002-12-17 | ニューロゲン コーポレイション | 9H−ピリミド[4、5−b]インドール誘導体:CRF1特異性リガンド |
| US6387894B1 (en) * | 1999-06-11 | 2002-05-14 | Pfizer Inc. | Use of CRF antagonists and renin-angiotensin system inhibitors |
| US6548509B2 (en) | 1999-10-22 | 2003-04-15 | Neurogen Corporation | 3-aryl substituted pyrazolo[4,3-D]pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| MXPA02007047A (es) * | 2000-01-18 | 2002-12-13 | Pfizer Prod Inc | Antagonista del factor liberador de corticotropina. |
| MXPA05012082A (es) | 2003-05-09 | 2006-02-22 | Pharmacia & Upjohn Co Llc | Compuestos como antagonistas del receptor crf1. |
| EP1626965A1 (en) | 2003-05-09 | 2006-02-22 | Pharmacia & Upjohn Company LLC | Pyrazinones as crf1 receptor antagonists for the treatment of cns disorders |
| AP2006003559A0 (en) | 2003-09-05 | 2006-04-30 | Neurogen Corp Ventis Pharmaceuticals Inc | Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF 1 receptor ligands |
| WO2005079807A1 (en) * | 2004-02-13 | 2005-09-01 | Pfizer Products Inc. | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists |
| US20080015196A1 (en) | 2004-04-16 | 2008-01-17 | Neurogen Corporation | Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| NL2000323C2 (nl) | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
| EP1834641A1 (en) | 2006-03-16 | 2007-09-19 | Sanofi-Aventis | Use of CRF1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia |
| ATE481405T1 (de) | 2006-09-20 | 2010-10-15 | Lilly Co Eli | Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors |
| TW200906825A (en) * | 2007-05-30 | 2009-02-16 | Scripps Research Inst | Inhibitors of protein kinases |
| JP2010529193A (ja) | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
| AU2008298657A1 (en) | 2007-09-14 | 2009-03-19 | The Scripps Research Institute | MPZP: a small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist |
| US20110301087A1 (en) | 2008-11-04 | 2011-12-08 | Mcbride Edward | Crf1 receptor compounds |
| TWI557112B (zh) * | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | β-分泌酶抑制劑 |
| AU2014227775B2 (en) | 2013-03-15 | 2018-05-31 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| IL296683B2 (en) | 2014-01-21 | 2023-12-01 | Neurocrine Biosciences Inc | Preparations for the treatment of congenital adrenal hyperplasia |
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2017
- 2017-09-06 KR KR1020197009639A patent/KR102571296B1/ko active Active
- 2017-09-06 AU AU2017324942A patent/AU2017324942B2/en active Active
- 2017-09-06 CN CN201780067124.3A patent/CN109906222B/zh active Active
- 2017-09-06 US US16/330,754 patent/US11077108B2/en active Active
- 2017-09-06 WO PCT/US2017/050347 patent/WO2018048953A1/en not_active Ceased
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- 2017-09-06 EP EP17849486.0A patent/EP3510029B1/en active Active
- 2017-09-06 JP JP2019533307A patent/JP7187037B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995033750A1 (en) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Corticotropin releasing factor antagonists |
| US20050032846A1 (en) * | 1995-11-08 | 2005-02-10 | Pfizer Inc. | Corticotropin releasing factor antagonists |
| WO2013123426A1 (en) * | 2012-02-18 | 2013-08-22 | Buck Institute For Research On Aging | Formulations and methods for the treatment or prophylaxis of pre-mci and/or pre-alzheimer's conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018048953A1 (en) | 2018-03-15 |
| EP3510029A4 (en) | 2020-03-11 |
| US11077108B2 (en) | 2021-08-03 |
| US20190307747A1 (en) | 2019-10-10 |
| KR20190057316A (ko) | 2019-05-28 |
| AU2017324942A1 (en) | 2019-04-18 |
| AU2017324942B2 (en) | 2022-01-27 |
| CN109906222A (zh) | 2019-06-18 |
| JP7187037B2 (ja) | 2022-12-12 |
| JP2019526639A (ja) | 2019-09-19 |
| EP3510029B1 (en) | 2025-11-05 |
| EP3510029A1 (en) | 2019-07-17 |
| CN109906222B (zh) | 2023-08-01 |
| CA3039026A1 (en) | 2018-03-15 |
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